From 0bbf8d8afd33f012f839a7b36fe3f627550c932f Mon Sep 17 00:00:00 2001 From: Heinrich Weil Date: Wed, 13 Oct 2021 16:53:36 +0200 Subject: [PATCH 1/2] add ecoli gene expression data set --- data/ecoliGeneExpression.tsv | 4298 ++++++++++++++++++++++ data/ecoliGeneExpression_description.txt | 27 + 2 files changed, 4325 insertions(+) create mode 100644 data/ecoliGeneExpression.tsv create mode 100644 data/ecoliGeneExpression_description.txt diff --git a/data/ecoliGeneExpression.tsv b/data/ecoliGeneExpression.tsv new file mode 100644 index 0000000..027deaf --- /dev/null +++ b/data/ecoliGeneExpression.tsv @@ -0,0 +1,4298 @@ +Key "Experiment 1" "Experiment 2" "Experiment 3" "Experiment 4" "Experiment 5" "Experiment 6" "Experiment 7" "Experiment 8" "Experiment 9" "Experiment 10" "Experiment 11" "Experiment 12" "Experiment 13" "Experiment 14" "Experiment 15" "Experiment 16" "Experiment 17" "Experiment 18" "Experiment 19" "Experiment 20" "Experiment 21" "Experiment 22" "Experiment 23" "Experiment 24" "Experiment 25" "Experiment 26" "Experiment 27" "Experiment 28" "Experiment 29" "Experiment 30" "Experiment 31" "Experiment 32" "Experiment 33" "Experiment 34" "Experiment 35" "Experiment 36" "Experiment 37" "Experiment 38" "Experiment 39" "Experiment 40" "Experiment 41" "Experiment 42" "Experiment 43" "Experiment 44" "Experiment 45" "Experiment 46" "Experiment 47" "Experiment 48" "Experiment 49" "Experiment 50" "Experiment 51" "Experiment 52" "Experiment 53" "Experiment 54" "Experiment 55" "Experiment 56" "Experiment 57" "Experiment 58" "Experiment 59" "Experiment 60" "Experiment 61" "Experiment 62" "Experiment 63" "Experiment 64" "Experiment 65" "Experiment 66" "Experiment 67" "Experiment 68" "Experiment 69" "Experiment 70" "Experiment 71" "Experiment 72" "Experiment 73" "Experiment 74" "Experiment 75" "Experiment 76" "Experiment 77" "Experiment 78" "Experiment 79" "Experiment 80" "Experiment 81" "Experiment 82" "Experiment 83" "Experiment 84" "Experiment 85" "Experiment 86" 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13.389 13.334 13.446 14.086 14.121 14.102 13.25 13.31 13.161 13.456 13.499 13.451 13.427 13.527 13.328 13.508 13.448 13.499 13.471 13.653 13.558 13.414 13.184 12.979 13.337 13.388 13.307 13.096 12.873 13.004 12.909 12.975 13.039 12.914 12.71 12.905 13.389 13.475 13.454 13.336 13.387 13.042 13.041 13.125 13.257 13.172 13.429 13.301 12.948 13.451 13.12 13.172 13.096 13.278 13.043 13.442 13.454 13.359 13.002 13.054 13.233 13.301 13.323 13.333 13.34 13.513 13.438 13.569 13.479 13.04 13.454 12.491 12.471 12.679 12.544 13.851 13.502 13.219 12.746 13.423 12.166 +rplL 12.728 12.788 12.685 12.92 12.912 12.888 13.13 13.038 12.672 12.593 12.966 12.993 12.973 12.875 12.795 12.974 13.084 13.069 13.078 12.878 12.906 12.885 13.449 13.404 13.382 12.628 12.795 12.624 12.81 12.869 12.725 12.733 12.738 12.778 12.864 12.824 12.76 12.64 12.965 12.909 13.218 12.818 12.518 12.521 12.869 12.965 12.631 12.621 12.735 12.733 12.726 12.876 12.653 12.48 12.744 12.907 12.715 12.885 13.055 13.041 12.934 12.571 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13.807 13.51 13.641 13.763 13.596 13.606 13.62 13.432 13.708 13.669 13.531 13.696 13.75 13.565 13.505 13.608 13.889 13.48 13.053 12.867 12.744 12.581 12.858 12.753 12.275 12.099 12.427 12.494 12.534 12.683 12.658 12.751 12.644 10.645 +rplW 12.926 12.928 12.996 13.085 13.32 13.204 13.432 13.362 13.384 13.326 13.489 13.632 13.488 13.597 13.565 13.454 13.507 13.496 13.512 13.491 13.337 13.469 13.897 13.9 13.891 13.57 13.582 13.472 13.494 13.533 13.373 13.305 13.395 13.186 13.201 13.292 13.239 13.309 13.356 13.346 13.754 13.674 13.711 13.442 13.478 13.432 13.321 13.26 13.252 13.322 13.427 13.403 13.148 13.039 13.021 13.535 13.416 13.443 13.668 13.67 13.515 13.23 13.222 13.349 13.455 13.63 13.653 13.575 13.572 13.578 13.553 13.478 13.527 13.449 13.578 13.464 13.45 13.468 13.523 13.416 13.534 13.581 13.684 13.176 13.008 12.735 12.408 12.265 12.963 12.606 12.384 12.265 12.401 12.473 12.212 12.237 12.496 11.891 12.19 10.031 +rplX 12.811 12.957 13.046 13.118 13.251 13.02 13.361 13.299 13.033 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11.343 11.441 10.383 +rpmB 12.567 12.778 12.441 12.612 12.523 12.745 12.96 12.927 12.783 12.488 12.925 12.724 13.284 13.114 13.146 13.256 13.065 12.833 13.222 12.811 12.757 12.693 13.231 13.098 12.947 13.559 13.594 13.549 13.818 13.796 13.781 13.766 13.551 13.761 13.807 13.61 13.58 13.412 13.719 13.68 12.793 12.532 12.5 12.188 12.569 12.518 12.365 12.141 11.905 11.983 12.101 12.106 11.861 11.687 11.82 12.476 12.253 12.603 12.546 12.565 12.248 11.867 12.191 12.518 12.574 12.765 12.537 11.994 12.913 12.456 12.678 12.562 12.602 12.535 12.681 12.661 12.55 12.456 12.361 12.355 12.686 12.691 12.619 13.874 13.755 13.591 13.563 13.563 13.145 13.332 12.503 12.614 12.784 12.704 13.555 13.573 13.616 12.138 12.532 11.456 +rpmC 10.35 10.904 10.865 11.304 11.726 11.211 11.86 11.74 12.087 12.228 12.402 12.456 12.474 12.592 12.318 12.244 12.455 12.264 12.159 12.156 12.107 12.392 13.276 13.26 13.221 12.532 12.582 12.224 12.364 12.099 11.922 11.974 11.933 11.883 11.814 12.007 11.987 12.012 12.109 12.05 12.171 12.114 12.226 11.944 11.836 11.734 11.675 11.63 11.937 11.673 11.875 11.977 11.644 11.341 11.453 11.749 11.829 11.679 12.238 12.22 12.212 11.516 11.477 11.875 12.022 12.458 12.452 11.977 12.243 12.504 12.202 12.043 11.967 12.053 12.004 12.017 12.001 12.174 12.135 11.883 12.177 12.262 12.533 11.92 11.956 11.489 11.627 11.212 11.367 11.375 10.564 10.34 10.847 10.823 11.332 11.499 11.643 11.613 11.517 9.4836 +rpmD 10.737 10.669 11.216 11.545 11.84 11.411 12.33 12.263 11.946 11.945 12.44 12.389 12.516 12.558 12.427 12.056 12.448 12.544 12.202 12.151 12.025 12.106 13.132 13.186 13.163 12.399 12.618 12.273 12.155 12.082 11.881 11.787 11.906 11.739 11.693 11.875 11.908 11.856 11.927 11.915 12.538 12.679 12.413 12.409 12.305 12.28 12.24 12.244 12.28 12.117 12.307 12.241 12.218 11.933 12.104 12.51 12.422 12.215 12.533 12.699 12.482 11.947 12.071 12.447 12.52 12.434 12.596 12.461 12.462 12.685 12.487 12.337 12.276 12.405 12.373 12.506 12.506 12.373 12.256 12.314 12.604 12.256 12.742 12.552 12.309 12.139 12.174 12.166 12.192 11.938 11.451 11.379 11.716 11.557 11.996 12.104 11.917 12.277 12.204 10.404 +rpmE 10.597 10.942 10.525 11.036 11.275 11.092 11.26 11.141 11.506 11.677 11.758 11.563 11.803 11.733 11.493 11.701 11.984 11.602 11.781 11.391 11.338 11.695 12.412 12.477 12.285 12.357 12.3 12.143 11.687 11.626 11.663 11.569 11.631 11.884 11.588 11.663 11.79 11.705 11.891 11.851 11.784 11.814 11.678 11.392 11.659 11.295 11.577 11.291 10.935 11.02 11.315 11.301 11.103 10.808 10.808 11.382 11.47 11.198 11.448 11.579 11.54 11.117 11.245 11.34 11.407 11.606 11.376 10.53 12.071 11.52 11.928 11.625 11.813 11.601 11.646 11.545 11.446 11.222 11.226 11.245 11.776 11.678 11.33 12.691 12.518 12.497 12.701 12.759 11.839 12.147 11.112 11.232 11.647 11.476 12.699 12.699 12.422 11.947 11.996 11.065 +rpmF 10.535 11.092 10.66 11.211 11.044 10.69 10.618 10.65 12.255 12.166 11.392 11.558 11.932 11.951 12.207 12.313 12.028 11.939 12.06 11.787 11.653 11.915 12.43 12.573 12.456 11.97 12.104 11.884 12.055 12.007 12.054 12.145 12.239 12.482 12.191 12.361 12.315 12.219 12.305 12.161 11.45 11.975 11.834 11.673 11.454 11.491 11.418 11.377 11.296 11.419 11.566 11.415 11.403 11.34 11.159 11.428 11.62 11.392 11.505 11.67 11.344 11.257 11.487 11.629 11.78 11.866 11.615 11.251 11.482 12.001 11.657 11.701 11.455 11.642 11.58 11.629 11.628 11.807 11.516 11.287 11.605 11.673 11.748 12.374 12.461 12.562 12.616 12.466 11.671 11.92 11.233 11.207 11.673 11.545 12.856 12.848 12.34 12.846 12.898 11.31 +rpmG 11.305 11.7 11.272 11.685 11.501 11.734 12.178 12.083 11.63 11.285 11.884 11.547 12.522 12.301 12.399 12.543 12.843 12.613 12.785 12.637 12.423 12.329 12.954 12.909 12.847 13.442 13.489 13.25 13.715 13.481 13.553 13.673 13.371 13.678 13.585 13.361 13.62 13.218 13.572 13.661 12.873 12.797 12.602 11.932 12.449 12.183 12.628 12.654 12.044 12.418 12.597 12.493 11.876 11.5 11.574 12.439 12.201 12.291 12.767 12.689 12.165 12.111 12.391 12.326 12.647 12.637 12.607 12.261 13.001 12.72 12.807 12.851 12.697 12.914 12.382 12.402 12.319 12.485 12.383 11.981 12.877 13.043 12.641 13.775 13.649 13.709 13.483 13.581 13.004 13.078 12.768 12.441 12.565 12.929 13.631 13.637 13.546 12.718 13.018 11.627 +rpmH 10.932 11.379 10.762 11.492 11.548 11.455 11.776 11.683 11.092 10.755 11.006 10.331 11.633 11.407 11.642 11.632 11.901 11.905 12.022 11.369 11.259 11.437 11.9 11.702 11.503 13.017 12.981 12.895 13.114 13.049 13.081 13.212 13.23 13.154 13.148 13.173 13.194 13.193 13.209 13.198 11.853 11.59 11.63 11.638 11.603 11.564 11.301 10.858 10.92 11.453 11.351 11.574 10.961 10.838 10.891 11.596 11.555 11.352 11.67 11.639 11.458 11.378 11.234 11.645 11.661 11.666 11.655 11.101 11.833 11.51 11.758 11.306 11.54 11.597 11.684 11.716 11.711 11.39 11.437 11.554 11.807 11.698 11.875 11.556 11.361 11.252 11.421 11.384 10.809 11.103 10.5 10.411 10.754 10.591 11.344 11.375 11.328 9.4065 9.3169 9.5789 +rpmI 10.786 11.062 10.768 11.034 10.903 10.93 11.103 11.157 11.73 12.008 11.812 11.607 11.89 11.839 11.868 11.964 12.278 12.128 12.238 11.979 11.986 12.055 12.579 12.616 12.701 12.363 12.434 12.312 12.521 12.411 12.399 12.398 12.392 12.585 12.373 12.321 12.539 12.383 12.557 12.574 12.429 12.491 12.517 12.258 12.119 12.252 12.649 12.49 12.291 12.546 12.651 12.473 12.319 12.109 12.149 12.214 12.128 11.865 12.253 12.05 12.353 12.134 12.864 12.257 12.278 12.362 12.289 12.085 12.268 12.474 12.341 12.424 12.108 12.501 12.171 12.013 11.947 12.385 12.07 11.775 12.091 12.384 12.325 12.846 12.863 12.989 12.944 12.797 12.402 12.61 12.24 12.201 12.389 12.117 13.064 13.019 13.17 12.918 13.09 12.384 +rpmJ 13.386 13.268 13.47 13.551 13.578 13.622 13.918 13.835 13.199 13.286 13.694 13.7 13.769 13.741 13.302 13.489 13.699 13.734 13.328 13.491 13.476 13.531 13.89 13.914 13.902 13.41 13.553 13.413 13.065 13.166 12.948 12.659 12.812 12.78 12.473 12.71 12.702 12.75 12.784 12.73 13.598 13.867 13.349 13.728 13.716 13.67 13.71 13.715 13.589 13.573 13.672 13.571 13.671 13.47 13.528 13.673 13.689 13.66 13.583 13.656 13.605 13.613 13.682 13.639 13.789 13.671 13.588 13.564 13.48 13.757 13.671 13.619 13.691 13.533 13.695 13.77 13.689 13.564 13.483 13.469 13.691 13.587 13.644 13.835 13.934 13.755 13.721 13.843 13.904 13.729 13.437 13.397 13.446 13.519 13.744 13.848 13.593 13.565 13.824 13.053 +rpoA 12.667 12.683 12.801 13.11 12.846 13.009 13.248 13.288 12.963 12.884 13.15 13.332 13.624 13.41 13.228 13.112 13.248 13.255 12.692 12.94 12.825 12.879 13.732 13.753 13.742 13.221 13.357 12.929 12.743 12.777 12.591 12.257 12.281 12.223 12.082 11.95 12.226 12.06 12.18 12.038 13.071 13.009 12.757 13.321 13.169 13.225 13.11 13.09 13.229 13.005 13.094 13.173 13.081 12.701 12.773 13.192 12.998 13.228 13.17 13.34 13.203 12.895 12.95 13.21 13.312 13.318 13.335 13.332 13.254 13.25 13.199 13.193 13.211 13.074 13.099 13.41 13.183 13.239 13.074 12.987 13.318 13.326 13.479 13.752 13.456 13.393 13.406 13.645 13.067 13.293 12.539 12.523 12.575 12.57 13.472 13.475 13.013 12.688 12.9 11.816 +rpoB 10.927 11.232 11.213 11.394 11.66 11.674 12.296 12.089 11.058 11.209 12.193 11.967 12.45 12.09 11.227 11.3 12.19 12.232 12.171 11.747 11.646 11.401 12.916 13.014 13.019 11.57 11.824 11.496 10.762 10.388 10.079 9.9335 9.7481 9.5907 9.9019 10.048 9.9817 9.7529 10.375 10.304 12.084 11.769 11.45 11.308 11.825 11.89 11.588 11.659 11.65 11.73 11.699 11.786 11.636 11.321 11.667 11.846 11.62 11.814 12.063 12.031 11.753 11.514 11.789 11.82 11.857 11.985 12.058 12.164 12.017 11.82 11.838 11.85 11.519 11.836 11.822 12.018 11.96 11.827 11.721 11.923 11.933 11.92 12.115 11.702 11.452 10.894 11.394 10.933 11.142 11.342 11.066 11.107 11.232 11.02 11.266 11.408 11.076 11.697 11.76 10.2 +rpoC 9.3149 9.5788 9.3627 9.6303 9.4987 9.7555 10.169 9.7597 9.298 9.405 10.377 10.111 10.644 10.469 9.1193 9.5167 10.206 10.06 10.168 10 9.6678 9.692 10.799 11.005 11.077 10.182 10.299 9.8087 8.8485 8.7288 8.3758 8.4113 8.2484 8.5246 8.5593 8.2056 8.1327 8.2293 8.6623 8.4412 10.031 9.6584 9.652 9.6205 10.038 10.022 9.6586 9.6404 9.891 9.7727 9.7467 9.8225 9.7948 9.4465 9.8338 9.8679 9.8404 9.9267 9.9117 10.006 9.9155 9.5512 9.7426 10.015 9.8557 10.047 10.056 10.098 9.957 9.9108 9.7415 9.9324 9.77 9.9706 9.8861 9.9308 10.123 9.9551 9.8566 10.036 9.8796 9.9029 10.354 9.6257 9.7711 9.4924 9.9566 9.423 9.2878 9.8959 9.4042 9.2137 9.6112 9.3709 9.732 9.7565 9.9154 10.173 9.953 9.3369 +rpoD 9.0857 9.3912 9.1409 9.5932 9.565 9.3556 10.99 11.127 10.158 10.145 10.796 10.456 11.437 11.16 11.211 11.29 9.8913 9.7423 10.003 9.9228 9.9348 9.4503 10.654 10.773 10.674 12.449 12.403 12.311 12.19 11.617 11.653 11.477 11.153 11.141 11.2 11.099 11.246 10.926 11.151 11.108 10.192 9.9133 10.038 9.8262 10.205 10.228 9.9879 9.9295 9.9369 9.95 9.8929 10.046 10.145 10.23 10.162 10.183 9.8108 10.23 10.196 10.189 9.578 9.8571 9.9059 10.221 10.059 10.171 10.189 10.118 10.057 10.118 9.9461 10.016 9.7207 9.8741 10.08 10.136 10.145 10.123 10.077 9.8834 9.9707 10.113 10.201 10.096 9.8567 9.6685 9.8589 9.3927 9.8036 10.028 9.8624 9.8404 9.9845 9.9313 9.2758 9.451 9.685 9.5113 9.7906 9.3886 +rpoE 10.291 10.93 10.44 10.706 9.8948 10.262 10.688 10.636 9.9103 10.045 10.507 10.029 9.8516 9.6636 10.41 10.526 10.296 9.9085 10.223 10.259 10.268 9.9426 10.202 9.987 10.111 8.8135 8.9432 8.7922 9.1894 9.1048 9.1729 9.0378 9.0826 9.2811 9.0241 8.8894 8.7385 8.5981 8.8848 8.8377 10.24 10.313 10.211 10.544 10.663 10.536 10.588 10.697 10.484 11.229 10.879 10.769 10.776 10.803 11.158 10.747 10.546 10.814 10.725 10.684 10.777 10.642 11.015 10.799 10.853 10.44 10.24 10.668 10.155 9.8621 9.9072 10.367 10.393 10.317 10.523 10.339 10.496 10.522 10.345 10.415 10.092 10.161 10.009 10.333 10.395 10.012 10.401 10.045 10.245 10.56 10.89 10.996 11.346 11.111 10.282 9.985 10.165 11.454 11.398 11.671 +rpoH 8.2268 8.5542 8.4539 8.721 9.0023 8.6456 9.382 9.3315 9.8487 9.7887 9.9092 9.8714 10.234 10.405 10.354 10.518 9.3348 9.1506 9.208 9.3792 9.334 9.5435 9.6117 9.6749 9.7475 10.514 10.342 10.039 9.8339 9.5419 9.535 9.5634 9.6004 9.4943 9.5052 9.3526 9.4618 9.5018 9.6213 9.5128 9.0834 9.0266 8.9316 8.8332 8.9652 8.9097 8.8866 9.0471 9.1026 9.208 9.0831 9.205 9.2486 9.274 9.3178 8.9336 9.0155 8.9273 9.0211 9.0973 8.9375 8.9413 9.0227 9.0352 8.9213 9.292 9.2429 9.3493 9.0075 8.9747 8.9744 9.1458 9.0752 9.1887 9.1391 9.109 9.0445 9.2282 9.3217 9.2848 9.0519 9.0912 9.1164 8.7245 9.0456 9.2813 8.7957 8.9147 8.9613 9.0136 8.9985 8.8684 9.0486 8.9583 8.7034 8.7751 9.1148 8.7917 8.8055 8.8782 +rpoN 10.689 10.853 10.394 10.666 10.86 10.57 11.091 11.129 10.559 10.496 10.938 11.061 10.733 10.775 10.619 10.61 10.79 10.679 10.939 11 11.072 10.964 10.743 10.709 10.857 10.854 10.904 10.811 11.148 11.092 10.95 10.728 10.884 10.859 10.343 10.572 10.339 10.378 10.272 10.152 11.285 11.152 11.25 11.267 11.213 11.102 11.234 11.251 11.303 11.479 11.367 11.389 11.551 11.65 11.484 11.249 11.356 11.064 11.22 11.252 11.226 11.442 11.54 11.214 11.26 11.287 11.175 11.468 11.085 11.035 11.062 11.146 11.245 11.165 11.28 11.191 11.161 11.447 11.461 11.416 11.116 11.067 11.026 10.46 10.513 10.149 10.415 10.23 10.691 10.761 10.802 10.663 10.937 10.854 10.106 10.342 9.9943 10.73 10.958 10.552 +rpoS 10.184 10.411 10.276 10.795 10.562 9.8405 10.636 10.759 11.007 11.065 11.307 11.195 10.986 11.082 11.153 11.059 11.355 11.541 11.456 11.732 11.791 11.848 10.588 10.627 10.656 10.487 10.586 10.41 10.439 10.455 10.363 9.9248 10.052 10.065 9.72 10.037 9.7718 10.157 9.8486 9.6523 11.846 11.584 11.528 11.367 11.446 11.474 12.073 12.325 12.231 12.145 12.326 12.253 12.684 12.824 12.587 11.444 11.53 11.492 11.382 11.512 11.412 11.037 11.559 11.492 11.3 11.94 12.02 12.269 11.635 11.951 11.685 11.856 12.068 12.041 12.077 12.09 12.053 12.403 12.352 12.306 11.822 11.709 11.896 11.623 11.478 10.912 11.842 11.727 11.891 12.096 12.469 12.611 12.602 12.796 11.652 11.721 11.571 12.91 12.889 12.936 +rpoZ 10.717 11.044 10.931 11.543 11.637 11.166 11.684 11.604 9.8721 9.6857 11.186 10.935 11.347 11.39 11.305 11.255 11.719 11.796 11.594 11.408 11.387 11.415 11.53 11.517 11.458 12.12 12.208 12.079 12.209 11.922 12.033 12.008 12.276 11.976 11.976 12.256 12.305 12.02 12.098 12.201 11.712 11.744 11.87 11.689 11.653 11.545 11.518 11.267 11.295 11.627 11.606 11.633 11.566 11.531 11.432 11.656 11.615 11.43 11.438 11.574 11.653 11.465 11.428 11.512 11.591 11.582 11.733 11.577 11.654 11.634 11.608 11.616 11.73 11.614 11.727 11.763 11.631 11.699 11.629 11.741 11.636 11.526 11.703 11.282 11.33 10.948 11.195 10.945 11.009 10.931 10.692 10.725 10.828 10.735 10.843 10.979 10.641 10.061 9.976 9.9407 +rppH 10.309 10.591 10.394 10.604 11.005 10.583 11.079 11.012 10.298 10.414 10.744 10.647 10.118 10.345 10.791 10.711 10.701 10.543 11.014 10.746 10.744 10.716 10.951 10.67 11.118 9.9118 9.9613 9.9576 10.267 10.215 10.228 10.214 10.454 10.27 10.253 10.367 10.39 10.437 10.419 10.573 10.679 10.741 10.709 10.945 10.889 10.73 10.803 10.818 10.535 10.761 10.785 10.69 10.532 10.581 10.388 10.817 10.79 10.771 10.838 10.878 10.867 10.901 10.714 10.758 10.879 10.572 10.589 10.522 10.776 10.629 10.791 10.694 10.886 10.683 10.761 10.824 10.69 10.62 10.664 10.667 10.67 10.6 10.548 10.202 10.121 9.772 10.03 9.9061 10.014 10.213 9.6498 9.7831 9.8453 9.9396 9.6741 9.6885 9.763 8.9147 9.2465 9.0881 +rprA 7.5137 6.7088 6.4701 5.8862 6.0859 6.5906 5.544 5.5719 6.3098 6.0121 5.764 6.2197 5.8787 6.4475 6.0983 6.3743 5.339 5.8536 5.6741 5.5221 5.9105 6.086 5.5525 5.5729 5.4122 5.4157 5.6996 5.5736 5.5608 5.7071 5.6695 5.5259 5.1834 5.693 5.9434 5.6251 5.9689 5.7975 5.875 5.9223 5.3606 5.2939 5.6111 5.6112 6.0222 5.8799 5.6011 6.2739 5.8887 5.8193 5.8293 5.8079 6.0708 5.9445 6.554 5.6631 5.6994 5.7851 5.7361 5.5999 5.6866 5.4555 5.4462 5.8588 5.7726 5.6284 5.5828 5.3765 5.8489 5.3791 6.0263 5.6498 5.5564 5.6436 5.5356 5.5104 5.5424 5.6204 5.6313 5.5544 5.7033 5.4957 5.4837 5.5576 6.2191 5.8121 6.0806 5.8075 5.8582 5.5159 5.9701 6.2758 5.0564 5.2593 5.8154 5.8181 6.1349 5.2414 5.7569 6.0368 +rpsA 12.083 12.143 12.139 12.279 12.031 11.965 12.196 12.199 11.952 11.906 12.348 12.17 12.325 12.37 12.51 12.481 12.619 12.608 12.576 12.031 11.862 11.957 13.162 13.296 13.185 12.92 12.727 12.898 12.698 12.46 12.518 12.377 12.449 12.338 12.197 12.239 12.204 12.142 12.186 12.069 12.803 12.99 13.017 12.603 12.633 12.673 12.573 12.439 12.354 12.509 12.681 12.544 12.523 12.3 12.373 12.613 12.582 12.574 12.6 12.504 12.621 12.4 12.543 12.668 12.647 12.563 12.584 12.487 12.545 12.705 12.528 12.673 12.564 12.514 12.566 12.435 12.618 12.636 12.487 12.508 12.459 12.598 12.813 13.208 13.111 13.071 12.932 13.008 12.625 12.754 11.869 11.995 12.192 12.109 12.868 13.019 12.917 12.24 12.535 11.493 +rpsB 11.676 12.027 11.847 12.154 11.472 12.303 12.349 12.315 12.566 12.531 12.631 12.32 12.483 12.315 12.651 12.733 12.686 12.722 12.503 12.064 12.093 11.858 13.242 13.281 13.212 12.845 12.874 12.821 13.006 12.903 12.956 12.898 12.969 13.064 12.693 12.964 12.865 12.521 12.675 12.701 12.181 12.494 12.66 12.301 12.173 12.305 12.1 12.146 11.765 12.053 12.383 12.003 12.022 11.689 11.831 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12.243 8.6618 11.98 12.682 8.4724 +znuB 9.0331 9.1026 8.6638 8.8863 8.2759 8.6164 8.3276 8.3036 8.4424 8.3284 8.5736 8.74 8.4687 8.4537 8.096 8.2206 8.3156 8.1489 8.4771 8.3806 8.3048 8.5047 8.3209 8.3942 8.3277 7.9299 8.2228 8.1901 7.9419 8.1267 7.9257 7.9779 7.8593 8.0151 8.2016 8.2228 7.9944 8.194 8.1305 8.2842 8.8215 8.818 8.9161 8.6395 8.6134 8.8633 8.5484 8.364 8.4959 8.7067 8.5482 8.5433 8.3157 8.3951 8.504 8.7266 8.4485 8.8506 8.8342 8.7358 8.652 8.74 8.7537 8.8255 8.6354 8.7971 8.6217 8.5608 8.5212 8.5305 8.4979 8.7295 8.5349 8.5923 8.8781 7.8092 8.6544 8.5268 8.5628 8.4338 8.4874 8.6264 8.505 9.0717 8.8312 9.0505 9.1035 9.0653 8.9582 9.0808 8.9855 8.8203 9.0423 8.9421 9.6731 9.8999 9.1852 8.6192 8.9813 9.1616 +znuC 6.7035 6.9724 6.6818 6.9352 6.7965 6.5792 6.9299 6.8395 7.465 7.3067 7.4267 7.5933 7.4469 7.3062 7.2508 7.2073 7.6265 7.381 7.599 7.487 7.3127 7.4567 7.7924 7.7432 7.6445 7.1689 7.1497 6.9525 7.1921 7.1884 6.9597 7.0737 6.7492 7.092 6.9566 7.0444 6.9105 7.0292 7.0526 6.9668 8.2348 8.115 8.2011 7.694 7.8447 7.9455 7.842 7.516 7.5145 7.5995 7.7271 7.6263 7.4494 7.4172 7.3857 8.0022 7.6908 7.7646 7.9614 7.8748 7.7393 7.7705 7.7943 8.054 7.9689 7.8953 7.8482 7.596 7.8472 7.7797 7.6859 7.8243 7.6497 7.6798 8.1657 7.616 7.9316 7.727 7.813 7.7947 7.8104 7.7645 7.7329 7.5967 7.521 7.5874 7.4417 7.3494 7.5286 7.5877 7.4371 7.3696 7.5763 7.4883 8.4016 8.4604 7.7656 8.4332 8.746 7.507 +zraP 8.8145 8.6138 8.9058 8.7784 8.7631 8.9499 8.621 8.6452 8.1034 7.9304 7.8889 8.3119 7.8926 8.3037 8.0371 8.0553 7.5125 7.5595 7.4823 7.4764 7.5728 7.6902 7.4801 7.6067 7.6323 7.576 7.6477 7.8595 7.6803 7.7057 8.0858 7.7412 7.8565 7.7627 7.7982 7.9528 7.8774 7.9725 7.937 7.9378 7.4469 7.6375 7.8577 7.9825 7.8652 7.7801 9.0025 11.122 8.4866 7.973 7.538 7.6764 9.0237 9.2712 8.7104 8.1714 8.2209 8.2954 7.8379 7.9831 8.3705 7.9986 8.0204 8.0208 8.0786 7.6681 7.5083 7.5866 7.4722 7.539 7.5002 7.3203 7.4539 7.3883 7.5835 7.4457 7.4247 7.59 7.5454 7.5186 7.5218 7.5943 7.5445 8.1167 7.9925 8.2143 7.909 8.0795 7.9602 7.8898 7.9449 7.77 7.5278 7.7946 7.6594 7.7959 7.9938 7.8249 7.6455 8.5436 +zraR 9.3121 9.2645 9.2973 9.3969 9.5913 9.3586 9.5042 9.3277 9.5137 9.5831 9.3952 9.679 9.5266 9.7149 9.5889 9.629 8.8916 9.022 8.8201 8.8491 8.8783 9.0015 8.8666 9.1273 9.043 9.0171 8.8817 8.9285 8.9811 9.0053 9.0984 8.9702 9.122 8.9892 9.0049 9.1238 9.0424 9.2783 9.2233 9.0958 8.8135 8.8628 9.0743 8.9275 8.8776 8.8479 8.7107 8.7805 8.9138 8.8164 8.7095 8.7789 8.8025 8.8097 8.8394 8.9257 8.9157 8.7885 8.8744 8.8101 8.9236 8.9919 8.9254 8.8279 8.8493 8.9459 8.8876 9.0333 8.7614 8.7779 8.8235 8.7774 8.8748 8.6988 8.952 8.9988 8.7524 8.8883 8.9514 8.8606 8.8136 8.8528 8.9599 8.948 8.9963 8.9685 8.7731 9.2059 9.1007 8.9929 9.0813 9.0204 8.8355 8.9542 8.9262 9.0134 8.979 9.2454 8.8802 9.129 +zraS 8.2207 8.0866 8.0818 8.2957 8.3431 8.2309 8.4978 8.3981 9.0054 9.1857 8.4998 8.5976 8.9515 9.0592 9.0375 8.9975 8.2771 8.3199 7.9388 8.1532 8.3277 8.1274 8.2188 8.1162 8.4071 7.304 7.1864 7.3859 7.4849 7.328 7.5595 7.2975 7.5228 7.3053 7.4748 7.5099 7.3731 7.5543 7.5313 7.4437 7.4174 7.7319 7.8658 7.8016 7.7635 7.553 7.6517 7.7971 7.7044 7.5419 7.6981 7.5921 7.5819 7.5637 7.5303 7.6956 7.7732 7.5814 7.6595 7.711 7.7162 7.8133 7.7355 7.6014 7.6523 7.6716 7.6184 7.6998 7.5557 7.5642 7.6629 7.5224 7.5885 7.556 7.5645 7.6204 7.4092 7.6411 7.5818 7.5575 7.6629 7.7256 7.6137 7.406 7.8646 7.9911 7.7626 7.6774 7.8006 7.6644 7.6076 7.604 7.6048 7.6622 7.5622 7.8234 7.6503 7.984 7.6436 7.702 +zupT 8.6416 8.7153 8.7112 8.7075 9.1074 8.9032 9.1696 9.1627 8.4549 8.4147 9.1534 8.816 8.6376 8.8974 8.9421 8.9591 8.6121 8.725 8.5651 8.5526 8.7038 8.8124 8.9102 9.0397 9.0335 8.3874 8.4478 8.4388 8.5459 8.3627 8.3975 8.4102 8.6622 8.6381 8.4159 8.6682 8.5767 8.4465 8.3455 8.5788 8.8764 8.9153 8.6316 9.0727 9.1043 9.0349 8.8398 8.9081 9.0381 9.0558 9.0089 8.9419 9.0714 9.1105 9.1122 9.1476 9.0436 9.1566 8.8655 9.0473 9.0539 9.0581 9.0857 9.0631 9.1944 8.8301 9.0159 9.2683 8.6299 8.9359 8.6481 8.9013 9.0428 8.9206 8.9897 9.0413 8.9048 9.1029 9.0923 9.2326 8.793 8.8292 8.9974 8.3808 8.4509 8.2402 8.4881 8.3811 8.5431 8.479 8.5214 8.4448 8.6861 8.429 8.2073 8.3436 8.1422 8.6772 8.4692 8.5687 +zur 8.6847 8.7107 8.6165 8.6928 9.1615 8.7433 9.3603 9.1481 8.9759 8.7591 9.1258 9.0985 9.1847 9.2025 9.5314 9.5565 8.1697 8.0861 7.9916 7.9434 8.0978 8.1284 8.9805 9.1591 9.2549 7.5596 7.5415 7.4992 7.6979 7.6186 7.7323 7.9196 8.0159 7.8962 7.9482 8.2276 8.1098 8.1487 8.2665 8.0624 8.3847 8.3182 8.2461 8.7142 8.812 8.7744 8.0549 7.9113 8.0589 8.3684 8.342 8.3654 8.2522 8.5016 8.2148 8.789 8.8486 8.7007 8.4809 8.5919 8.5873 8.7633 8.7677 8.7674 8.6527 8.3603 8.2212 8.5264 8.1534 8.2682 8.074 8.1084 8.2727 8.0997 8.4101 8.5003 8.3106 8.256 8.292 8.4406 8.1671 8.1374 8.2395 7.2793 7.7882 7.8364 7.7241 7.5331 7.5475 7.9267 7.4714 7.5974 7.6119 7.4148 7.451 7.5061 7.8756 7.9528 7.7245 7.579 +zwf 8.8903 9.4386 9.0222 9.4796 9.7052 9.209 9.917 9.9838 9.925 9.9099 9.5643 9.5938 9.3155 9.522 9.4667 9.5517 10.022 9.5678 10.016 9.6658 9.6542 9.6515 10.155 10.313 10.272 9.5402 9.5418 9.5506 8.8892 9.0202 8.6739 8.5598 8.9007 8.7764 8.8359 8.9679 8.6516 8.8991 8.7782 8.6245 10.662 10.938 11.006 10.753 10.747 10.696 10.835 10.855 10.687 10.78 11.023 11.019 10.985 11.1 10.848 10.62 10.576 10.49 10.996 10.615 10.752 10.863 10.696 10.743 10.994 10.7 10.614 10.86 10.398 10.693 10.408 10.669 10.681 10.433 10.639 10.7 10.522 10.786 11.047 10.792 10.355 10.414 10.516 9.7132 9.9145 9.6542 9.8571 9.6697 9.6841 9.6355 9.2115 9.2333 9.5058 9.2429 9.4711 9.409 9.7533 9.6935 9.8698 8.9902 diff --git a/data/ecoliGeneExpression_description.txt b/data/ecoliGeneExpression_description.txt new file mode 100644 index 0000000..62fb7a5 --- /dev/null +++ b/data/ecoliGeneExpression_description.txt @@ -0,0 +1,27 @@ +Original Description: +====== + +Microarray compendia compiled by Diogo Camacho and others at the Jim Collins group for the DREAM5 network inference challenge. + +Data were exported from original Matlab files by Daniel Marbach. + +These are the original files before preparation for the challenge. (Subsequently, datasets were anonymized, including addition of some genes with random expression data. The official datasets of the challenge are provided as supplement of the paper) + +Citation: +Nature Methods cover Wisdom of crowds for robust gene network inference. +Marbach D*, Costello JC*, KŸffner R*, Vega NM, Prill RJ, Camacho DM, Allison KR, The DREAM5 Consortium, Kellis M, Collins JJ, Stolovitzky G. Nature Methods, 9(8):796-804, 2012. +http://www.ncbi.nlm.nih.gov/pubmed/22796662 + + +-- +Daniel Marbach + +------------------------------------------------------ + +Changes Made: +====== + +Frames from the Dream5 challenge were combined and a smaller subset of experiments was taken. + +-- +H. Lukas Weil \ No newline at end of file From 9a5a986b6f793b9454acdabefd792e4438cb912a Mon Sep 17 00:00:00 2001 From: Heinrich Weil Date: Thu, 14 Oct 2021 11:17:26 +0200 Subject: [PATCH 2/2] add ecoli annotation table --- data/ecoli_annotation.tab | 4439 +++++++++++++++++++++++++ data/ecoli_annotation_description.txt | 9 + 2 files changed, 4448 insertions(+) create mode 100644 data/ecoli_annotation.tab create mode 100644 data/ecoli_annotation_description.txt diff --git a/data/ecoli_annotation.tab b/data/ecoli_annotation.tab new file mode 100644 index 0000000..5639d02 --- /dev/null +++ b/data/ecoli_annotation.tab @@ -0,0 +1,4439 @@ +Entry Entry name Protein names Gene names Gene names (synonym ) Gene names (primary ) Mass Gene ontology (biological process) Gene ontology (cellular component) Gene ontology (GO) Gene ontology (molecular function) Gene ontology IDs Subcellular location [CC] Tissue specificity +P0AAG8 MGLA_ECOLI Galactose/methyl galactoside import ATP-binding protein MglA (EC 7.5.2.11) mglA b2149 JW2136 mglA 56,415 cellular response to DNA damage stimulus [GO:0006974]; galactose transmembrane transport [GO:0015757]; methylgalactoside transport [GO:0015765] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ABC-type carbohydrate transporter activity [GO:0043211]; ATP binding [GO:0005524]; galactose transmembrane transporter activity [GO:0005354]; methylgalactoside transmembrane transporter activity [GO:0015592]; cellular response to DNA damage stimulus [GO:0006974]; galactose transmembrane transport [GO:0015757]; methylgalactoside transport [GO:0015765] ABC-type carbohydrate transporter activity [GO:0043211]; ATP binding [GO:0005524]; galactose transmembrane transporter activity [GO:0005354]; methylgalactoside transmembrane transporter activity [GO:0015592] GO:0005354; GO:0005524; GO:0005886; GO:0006974; GO:0015592; GO:0015757; GO:0015765; GO:0043211 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:6294056}; Peripheral membrane protein {ECO:0000305|PubMed:6294056}. +P0A749 MURA_ECOLI UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) (Enoylpyruvate transferase) (UDP-N-acetylglucosamine enolpyruvyl transferase) (EPT) murA murZ b3189 JW3156 murZ murA 44,818 cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; UDP-N-acetylgalactosamine biosynthetic process [GO:0019277] cytosol [GO:0005829] cytosol [GO:0005829]; UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity [GO:0008760]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; UDP-N-acetylgalactosamine biosynthetic process [GO:0019277] UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity [GO:0008760] GO:0005829; GO:0007049; GO:0008360; GO:0008760; GO:0009252; GO:0019277; GO:0051301; GO:0071555 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00111, ECO:0000305}. +P77737 OPPF_ECOLI Oligopeptide transport ATP-binding protein OppF oppF b1247 JW1239 oppF 37,198 protein transport [GO:0015031] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; protein transport [GO:0015031] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0015031; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. +P23837 PHOQ_ECOLI Sensor protein PhoQ (EC 2.7.13.3) (EC 3.1.3.-) (Sensor histidine protein kinase/phosphatase PhoQ) phoQ b1129 JW1115 phoQ 55,300 cellular response to magnesium starvation [GO:0010350]; osmosensory signaling via phosphorelay pathway [GO:0007234]; phosphorelay signal transduction system [GO:0000160]; protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155]; cellular response to magnesium starvation [GO:0010350]; osmosensory signaling via phosphorelay pathway [GO:0007234]; phosphorelay signal transduction system [GO:0000160]; protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155] GO:0000155; GO:0000160; GO:0004721; GO:0005524; GO:0005886; GO:0005887; GO:0007165; GO:0007234; GO:0010350; GO:0016301; GO:0042802; GO:0046777; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P23865 PRC_ECOLI Tail-specific protease (EC 3.4.21.102) (C-terminal-processing peptidase) (PRC protein) (Protease Re) prc tsp b1830 JW1819 tsp prc 76,663 protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; response to antibiotic [GO:0046677]; signal transduction [GO:0007165] outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; response to antibiotic [GO:0046677]; signal transduction [GO:0007165] endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252] GO:0004175; GO:0004252; GO:0005886; GO:0006508; GO:0007165; GO:0030163; GO:0030288; GO:0046677 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; Periplasmic side. +P32155 PTFLA_ECOLI PTS system fructose-like EIIA component (Fructose-like phosphotransferase enzyme IIA component) frvA yiiK b3900 JW3871 yiiK frvA 16,094 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737]; integral component of membrane [GO:0016021] cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982] GO:0005737; GO:0008982; GO:0009401; GO:0016021; GO:0016301 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P69801 PTNC_ECOLI PTS system mannose-specific EIIC component (EII-P-Man) (EIIC-Man) (Mannose permease IIC component) manY pel ptsP b1818 JW1807 pel ptsP manY 27,636 glucose import across plasma membrane [GO:0098708]; mannose transmembrane transport [GO:0015761]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity [GO:0022870]; glucose import across plasma membrane [GO:0098708]; mannose transmembrane transport [GO:0015761]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity [GO:0022870] GO:0005886; GO:0005887; GO:0009401; GO:0015761; GO:0016020; GO:0022870; GO:0098708 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00429, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:31209249, ECO:0000269|PubMed:8774730}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00429, ECO:0000269|PubMed:31209249}. +P65870 QUED_ECOLI 6-carboxy-5,6,7,8-tetrahydropterin synthase (CPH4 synthase) (EC 4.1.2.50) (Queuosine biosynthesis protein QueD) queD ygcM b2765 JW2735 ygcM queD 13,773 queuosine biosynthetic process [GO:0008616] 6-carboxy-5,6,7,8-tetrahydropterin synthase activity [GO:0070497]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; queuosine biosynthetic process [GO:0008616] 6-carboxy-5,6,7,8-tetrahydropterin synthase activity [GO:0070497]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] GO:0008270; GO:0008616; GO:0042802; GO:0070497 +P0AAZ4 RARA_ECOLI Replication-associated recombination protein A rarA mgsA ycaJ b0892 JW0875 mgsA ycaJ rarA 49,626 DNA-dependent DNA replication [GO:0006261]; DNA recombination [GO:0006310]; regulation of DNA repair [GO:0006282] replisome [GO:0030894] replisome [GO:0030894]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; single-stranded DNA helicase activity [GO:0017116]; DNA recombination [GO:0006310]; DNA-dependent DNA replication [GO:0006261]; regulation of DNA repair [GO:0006282] ATP binding [GO:0005524]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; single-stranded DNA helicase activity [GO:0017116] GO:0003677; GO:0005524; GO:0006261; GO:0006282; GO:0006310; GO:0008047; GO:0017116; GO:0030894 +P0A7R1 RL9_ECOLI 50S ribosomal protein L9 (Large ribosomal subunit protein bL9) rplI b4203 JW4161 rplI 15,769 translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412] large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735] GO:0003735; GO:0005829; GO:0006412; GO:0022625; GO:0070180 +P0AA43 RSUA_ECOLI Ribosomal small subunit pseudouridine synthase A (EC 5.4.99.19) (16S pseudouridylate 516 synthase) (16S rRNA pseudouridine(516) synthase) (rRNA pseudouridylate synthase A) (rRNA-uridine isomerase A) rsuA yejD b2183 JW2171 yejD rsuA 25,865 enzyme-directed rRNA pseudouridine synthesis [GO:0000455] cytosol [GO:0005829] cytosol [GO:0005829]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159] GO:0000455; GO:0003723; GO:0005829; GO:0009982; GO:0120159 +P0AGD3 SODF_ECOLI Superoxide dismutase [Fe] (EC 1.15.1.1) sodB b1656 JW1648 sodB 21,266 removal of superoxide radicals [GO:0019430]; response to superoxide [GO:0000303]; superoxide metabolic process [GO:0006801] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; superoxide dismutase activity [GO:0004784]; removal of superoxide radicals [GO:0019430]; response to superoxide [GO:0000303]; superoxide metabolic process [GO:0006801] iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; superoxide dismutase activity [GO:0004784] GO:0000303; GO:0004784; GO:0005506; GO:0005737; GO:0005829; GO:0006801; GO:0016020; GO:0016491; GO:0019430 +P30852 SMF_ECOLI Protein Smf smf b4473 JW5708 smf 40,955 DNA mediated transformation [GO:0009294] DNA mediated transformation [GO:0009294] GO:0009294 +P76053 SMRA_ECOLI Probable DNA endonuclease SmrA (EC 3.1.-.-) smrA ydaL b1340 JW1334 ydaL smrA 21,512 DNA binding [GO:0003677]; endodeoxyribonuclease activity [GO:0004520] DNA binding [GO:0003677]; endodeoxyribonuclease activity [GO:0004520] GO:0003677; GO:0004520 +P76112 MNAT_ECOLI L-amino acid N-acyltransferase MnaT (EC 2.3.1.-) (L-methionine N-acyltransferase) (L-methionine sulfoximine/L-methionine sulfone N-acetyltransferase) (L-phenylglycine N-acetyltransferase) mnaT yncA b1448 JW5233 yncA mnaT 19,248 methione N-acyltransferase activity [GO:0103045]; N-acetyltransferase activity [GO:0008080]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] methione N-acyltransferase activity [GO:0103045]; N-acetyltransferase activity [GO:0008080]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] GO:0008080; GO:0016747; GO:0103045 +P0ACV2 LPXP_ECOLI Lipid A biosynthesis palmitoleoyltransferase (EC 2.3.1.242) (Kdo(2)-lipid IV(A) palmitoleoyltransferase) lpxP ddg b2378 JW2375 ddg lpxP 35,493 Kdo2-lipid A biosynthetic process [GO:0036104]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; response to cold [GO:0009409] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity [GO:0008951]; Kdo2-lipid A biosynthetic process [GO:0036104]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; response to cold [GO:0009409] palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity [GO:0008951] GO:0005887; GO:0008951; GO:0009103; GO:0009245; GO:0009409; GO:0036104 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01943, ECO:0000305}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01943}. +P0AGC5 MLTF_ECOLI Membrane-bound lytic murein transglycosylase F (EC 4.2.2.n1) (Murein lyase F) mltF yfhD b2558 JW2542 yfhD mltF 58,302 cell wall macromolecule catabolic process [GO:0016998]; cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; carbon-oxygen lyase activity, acting on polysaccharides [GO:0016837]; lytic transglycosylase activity [GO:0008933]; cell wall macromolecule catabolic process [GO:0016998]; cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253] carbon-oxygen lyase activity, acting on polysaccharides [GO:0016837]; lytic transglycosylase activity [GO:0008933] GO:0008933; GO:0009253; GO:0009279; GO:0016837; GO:0016998; GO:0071555 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_02016, ECO:0000269|PubMed:18234673}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_02016, ECO:0000269|PubMed:18234673}. Note=Attached to the inner leaflet of the outer membrane. +P0A746 MSRB_ECOLI Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12) (Peptide-methionine (R)-S-oxide reductase) msrB yeaA b1778 JW1767 yeaA msrB 15,451 protein repair [GO:0030091]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; iron ion binding [GO:0005506]; peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; zinc ion binding [GO:0008270]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979] iron ion binding [GO:0005506]; peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; zinc ion binding [GO:0008270] GO:0005506; GO:0005737; GO:0005829; GO:0006979; GO:0008270; GO:0030091; GO:0033743 +P77165 PAOA_ECOLI Aldehyde oxidoreductase iron-sulfur-binding subunit PaoA (EC 1.2.99.6) paoA yagT b0286 JW0280 yagT paoA 24,343 periplasmic space [GO:0042597] periplasmic space [GO:0042597]; 2 iron, 2 sulfur cluster binding [GO:0051537]; carboxylate reductase activity [GO:0047770]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on the aldehyde or oxo group of donors [GO:0016903] 2 iron, 2 sulfur cluster binding [GO:0051537]; carboxylate reductase activity [GO:0047770]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on the aldehyde or oxo group of donors [GO:0016903] GO:0009055; GO:0016903; GO:0042597; GO:0046872; GO:0047770; GO:0051537 SUBCELLULAR LOCATION: Periplasm {ECO:0000305|PubMed:19368556}. +P07003 POXB_ECOLI Pyruvate dehydrogenase [ubiquinone] (EC 1.2.5.1) (Pyruvate oxidase) (POX) (Pyruvate:ubiquinone-8 oxidoreductase) poxB b0871 JW0855 poxB 62,011 pyruvate catabolic process [GO:0042867]; pyruvate metabolic process [GO:0006090] cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; magnesium ion binding [GO:0000287]; pyruvate dehydrogenase (quinone) activity [GO:0052737]; thiamine pyrophosphate binding [GO:0030976]; ubiquinone binding [GO:0048039]; pyruvate catabolic process [GO:0042867]; pyruvate metabolic process [GO:0006090] flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; magnesium ion binding [GO:0000287]; pyruvate dehydrogenase (quinone) activity [GO:0052737]; thiamine pyrophosphate binding [GO:0030976]; ubiquinone binding [GO:0048039] GO:0000287; GO:0005829; GO:0005886; GO:0006090; GO:0008289; GO:0030976; GO:0032991; GO:0042802; GO:0042867; GO:0048039; GO:0050660; GO:0052737 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00850, ECO:0000269|PubMed:365232, ECO:0000305|PubMed:5336022}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00850, ECO:0000269|PubMed:365232, ECO:0000305|PubMed:5336022}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_00850, ECO:0000269|PubMed:365232}. +P02359 RS7_ECOLI 30S ribosomal protein S7 (Small ribosomal subunit protein uS7) rpsG b3341 JW3303 rpsG 20,019 negative regulation of translation [GO:0017148]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; membrane [GO:0016020]; ribosome [GO:0005840] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; membrane [GO:0016020]; ribosome [GO:0005840]; mRNA binding [GO:0003729]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049]; negative regulation of translation [GO:0017148]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] mRNA binding [GO:0003729]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049] GO:0000028; GO:0000049; GO:0003729; GO:0003735; GO:0005829; GO:0005840; GO:0006412; GO:0016020; GO:0017148; GO:0019843; GO:0022627 +P46187 RSEC_ECOLI Protein RseC rseC b2570 JW2554 rseC 16,639 response to oxidative stress [GO:0006979] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; response to oxidative stress [GO:0006979] GO:0005886; GO:0006979; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P0AGB0 SERB_ECOLI Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (O-phosphoserine phosphohydrolase) serB b4388 JW4351 serB 35,043 cellular amino acid biosynthetic process [GO:0008652]; dephosphorylation [GO:0016311]; L-serine biosynthetic process [GO:0006564] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; D-phosphoserine phosphatase activity [GO:0036425]; L-phosphoserine phosphatase activity [GO:0036424]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; phosphoserine phosphatase activity [GO:0004647]; cellular amino acid biosynthetic process [GO:0008652]; dephosphorylation [GO:0016311]; L-serine biosynthetic process [GO:0006564] D-phosphoserine phosphatase activity [GO:0036425]; L-phosphoserine phosphatase activity [GO:0036424]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; phosphoserine phosphatase activity [GO:0004647] GO:0000287; GO:0004647; GO:0005737; GO:0006564; GO:0008652; GO:0016311; GO:0016791; GO:0036424; GO:0036425 +P21170 SPEA_ECOLI Biosynthetic arginine decarboxylase (ADC) (EC 4.1.1.19) speA b2938 JW2905 speA 73,898 arginine catabolic process [GO:0006527]; putrescine biosynthetic process [GO:0009446]; putrescine biosynthetic process from arginine [GO:0033388]; spermidine biosynthetic process [GO:0008295] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; arginine decarboxylase activity [GO:0008792]; metal ion binding [GO:0046872]; arginine catabolic process [GO:0006527]; putrescine biosynthetic process [GO:0009446]; putrescine biosynthetic process from arginine [GO:0033388]; spermidine biosynthetic process [GO:0008295] arginine decarboxylase activity [GO:0008792]; metal ion binding [GO:0046872] GO:0006527; GO:0008295; GO:0008792; GO:0009446; GO:0033388; GO:0042597; GO:0046872 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:2198270}. +P0A8W2 SLYA_ECOLI Transcriptional regulator SlyA slyA b1642 JW5267 slyA 16,353 negative regulation of DNA-templated transcription, initiation [GO:2000143]; pathogenesis [GO:0009405]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of DNA-templated transcription, initiation [GO:2000143]; pathogenesis [GO:0009405]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355; GO:0009405; GO:0045893; GO:2000143; GO:2000144 +P0AGC7 SMP_ECOLI Probable inner membrane protein Smp ytjB smp b4387 JW4350 smp ytjB 24,083 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:2684780}; Single-pass membrane protein {ECO:0000255}. +P77326 TFAS_ECOLI Putative protein TfaS (Putative tail fiber assembly protein homolog from prophage CPS-53) tfaS b2353 JW5383 tfaS 12,658 +P02929 TONB_ECOLI Protein TonB tonB exbA b1252 JW5195 exbA tonB 26,094 cobalamin transport [GO:0015889]; colicin transport [GO:0042914]; protein transport [GO:0015031]; receptor-mediated bacteriophage irreversible attachment to host cell [GO:0098002]; siderophore transport [GO:0015891] cell envelope [GO:0030313]; integral component of external side of plasma membrane [GO:0071575]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797] cell envelope [GO:0030313]; integral component of external side of plasma membrane [GO:0071575]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; energy transducer activity [GO:0031992]; protein domain specific binding [GO:0019904]; siderophore transmembrane transporter activity [GO:0015343]; cobalamin transport [GO:0015889]; colicin transport [GO:0042914]; protein transport [GO:0015031]; receptor-mediated bacteriophage irreversible attachment to host cell [GO:0098002]; siderophore transport [GO:0015891] energy transducer activity [GO:0031992]; protein domain specific binding [GO:0019904]; siderophore transmembrane transporter activity [GO:0015343] GO:0005886; GO:0015031; GO:0015343; GO:0015889; GO:0015891; GO:0019904; GO:0030288; GO:0030313; GO:0031992; GO:0042914; GO:0071575; GO:0098002; GO:0098797 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein; Periplasmic side. +P0AAR0 TOMB_ECOLI Hha toxicity modulator TomB (Toxin overexpression modulator in biofilms) tomB ybaJ b0461 JW0450 ybaJ tomB 14,557 single-species biofilm formation [GO:0044010] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; single-species biofilm formation [GO:0044010] DNA binding [GO:0003677] GO:0003677; GO:0005737; GO:0044010 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P36938 PGM_ECOLI Phosphoglucomutase (PGM) (EC 5.4.2.2) (Glucose phosphomutase) pgm b0688 JW0675 pgm 58,361 carbohydrate metabolic process [GO:0005975]; glucose metabolic process [GO:0006006] cytosol [GO:0005829] cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614]; carbohydrate metabolic process [GO:0005975]; glucose metabolic process [GO:0006006] magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614] GO:0000287; GO:0004614; GO:0005829; GO:0005975; GO:0006006 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21778229}. +P55799 PRP2_ECOLI Serine/threonine-protein phosphatase 2 (EC 3.1.3.16) pphB prpB ygbH b2734 JW2704 prpB ygbH pphB 25,098 metal ion binding [GO:0046872]; protein serine phosphatase activity [GO:0106306]; protein threonine phosphatase activity [GO:0106307]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138] metal ion binding [GO:0046872]; protein serine phosphatase activity [GO:0106306]; protein threonine phosphatase activity [GO:0106307]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138] GO:0008138; GO:0046872; GO:0106306; GO:0106307 +P42911 PTPD_ECOLI N-acetylgalactosamine permease IID component (EIID-Aga) (PTS system N-acetylgalactosamine-specific EIID component) agaD yraF b3140 JW3109 yraF agaD 29,001 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] GO:0005886; GO:0005887; GO:0009401 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00431, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00431, ECO:0000269|PubMed:15919996}. +P0A7D4 PURA_ECOLI Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase) purA adeK b4177 JW4135 adeK purA 47,345 'de novo' AMP biosynthetic process [GO:0044208]; adenosine biosynthetic process [GO:0046086]; cellular response to DNA damage stimulus [GO:0006974]; IMP metabolic process [GO:0046040]; nucleobase-containing small molecule interconversion [GO:0015949]; purine nucleotide biosynthetic process [GO:0006164] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; adenylosuccinate synthase activity [GO:0004019]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; 'de novo' AMP biosynthetic process [GO:0044208]; adenosine biosynthetic process [GO:0046086]; cellular response to DNA damage stimulus [GO:0006974]; IMP metabolic process [GO:0046040]; nucleobase-containing small molecule interconversion [GO:0015949]; purine nucleotide biosynthetic process [GO:0006164] adenylosuccinate synthase activity [GO:0004019]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287] GO:0000287; GO:0004019; GO:0005525; GO:0005737; GO:0005829; GO:0006164; GO:0006974; GO:0015949; GO:0016020; GO:0044208; GO:0046040; GO:0046086 SUBCELLULAR LOCATION: Cytoplasm. +P0A7E5 PYRG_ECOLI CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase) pyrG b2780 JW2751 pyrG 60,374 'de novo' CTP biosynthetic process [GO:0044210]; CTP biosynthetic process [GO:0006241]; glutamine metabolic process [GO:0006541]; protein homotetramerization [GO:0051289]; pyrimidine nucleobase biosynthetic process [GO:0019856] cytoophidium [GO:0097268]; cytosol [GO:0005829] cytoophidium [GO:0097268]; cytosol [GO:0005829]; ATP binding [GO:0005524]; CTP synthase activity [GO:0003883]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; 'de novo' CTP biosynthetic process [GO:0044210]; CTP biosynthetic process [GO:0006241]; glutamine metabolic process [GO:0006541]; protein homotetramerization [GO:0051289]; pyrimidine nucleobase biosynthetic process [GO:0019856] ATP binding [GO:0005524]; CTP synthase activity [GO:0003883]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287] GO:0000287; GO:0003883; GO:0005524; GO:0005829; GO:0006241; GO:0006541; GO:0019856; GO:0042802; GO:0044210; GO:0051289; GO:0097268 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32507415}. Note=Localizes to the cytoophidium, a subcellular filamentary structure where CTP synthase is compartmentalized. Many cells form cytoophidia which are observed in stationary phase. {ECO:0000269|PubMed:32507415}. +P33221 PURT_ECOLI Formate-dependent phosphoribosylglycinamide formyltransferase (5'-phosphoribosylglycinamide transformylase 2) (Formate-dependent GAR transformylase) (EC 2.1.2.-) (GAR transformylase 2) (GART 2) (Non-folate glycinamide ribonucleotide transformylase) (Phosphoribosylglycinamide formyltransferase 2) purT b1849 JW1838 purT 42,434 'de novo' IMP biosynthetic process [GO:0006189] cytosol [GO:0005829] cytosol [GO:0005829]; acetate kinase activity [GO:0008776]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phosphoribosylglycinamide formyltransferase 2 activity [GO:0043815]; phosphoribosylglycinamide formyltransferase activity [GO:0004644]; 'de novo' IMP biosynthetic process [GO:0006189] acetate kinase activity [GO:0008776]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phosphoribosylglycinamide formyltransferase 2 activity [GO:0043815]; phosphoribosylglycinamide formyltransferase activity [GO:0004644] GO:0000287; GO:0004644; GO:0005524; GO:0005829; GO:0006189; GO:0008776; GO:0043815 +P24230 RECG_ECOLI ATP-dependent DNA helicase RecG (EC 3.6.4.12) recG radC b3652 JW3627 radC recG 76,430 DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; response to radiation [GO:0009314] cytosol [GO:0005829]; Holliday junction helicase complex [GO:0009379] cytosol [GO:0005829]; Holliday junction helicase complex [GO:0009379]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; response to radiation [GO:0009314] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678] GO:0003677; GO:0003678; GO:0005524; GO:0005829; GO:0006281; GO:0006310; GO:0009314; GO:0009379; GO:0032508 +P32156 RHAM_ECOLI L-rhamnose mutarotase (EC 5.1.3.32) (Rhamnose 1-epimerase) (Type-3 mutarotase) rhaM yiiL b3901 JW3872 yiiL rhaM 12,265 rhamnose catabolic process [GO:0019301] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; L-rhamnose mutarotase activity [GO:0062192]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]; rhamnose catabolic process [GO:0019301] L-rhamnose mutarotase activity [GO:0062192]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857] GO:0005737; GO:0016857; GO:0019301; GO:0062192 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AGL7 RSME_ECOLI Ribosomal RNA small subunit methyltransferase E (EC 2.1.1.193) (16S rRNA m3U1498 methyltransferase) rsmE yggJ b2946 JW2913 yggJ rsmE 26,978 rRNA base methylation [GO:0070475] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; rRNA (uridine-N3-)-methyltransferase activity [GO:0070042]; rRNA base methylation [GO:0070475] rRNA (uridine-N3-)-methyltransferase activity [GO:0070042] GO:0005737; GO:0070042; GO:0070475 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P06992 RSMA_ECOLI Ribosomal RNA small subunit methyltransferase A (EC 2.1.1.182) (16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase) (16S rRNA dimethyladenosine transferase) (16S rRNA dimethylase) (High level kasugamycin resistance protein KsgA) (Kasugamycin dimethyltransferase) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) rsmA ksgA b0051 JW0050 ksgA rsmA 30,420 response to antibiotic [GO:0046677]; ribosomal small subunit assembly [GO:0000028]; rRNA base methylation [GO:0070475]; rRNA methylation [GO:0031167]; rRNA processing [GO:0006364] cytosol [GO:0005829] cytosol [GO:0005829]; 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity [GO:0052908]; double-stranded DNA binding [GO:0003690]; mRNA binding [GO:0003729]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]; rRNA binding [GO:0019843]; response to antibiotic [GO:0046677]; ribosomal small subunit assembly [GO:0000028]; rRNA base methylation [GO:0070475]; rRNA methylation [GO:0031167]; rRNA processing [GO:0006364] 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity [GO:0052908]; double-stranded DNA binding [GO:0003690]; mRNA binding [GO:0003729]; rRNA (adenine-N6,N6-)-dimethyltransferase activity [GO:0000179]; rRNA binding [GO:0019843] GO:0000028; GO:0000179; GO:0003690; GO:0003729; GO:0005829; GO:0006364; GO:0019843; GO:0031167; GO:0046677; GO:0052908; GO:0070475 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P76136 SAFA_ECOLI Two-component-system connector protein SafA (Regulatory protein b1500) (Sensor associating factor A) safA yneN b1500 JW1494.1 yneN safA 7,272 response to acidic pH [GO:0010447] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; response to acidic pH [GO:0010447] GO:0005887; GO:0010447 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:17998538}; Single-pass type II membrane protein {ECO:0000269|PubMed:17998538}. +P0A821 SELA_ECOLI L-seryl-tRNA(Sec) selenium transferase (EC 2.9.1.1) (Selenocysteine synthase) (Sec synthase) (Selenocysteinyl-tRNA(Sec) synthase) selA fdhA b3591 JW3564 fdhA selA 50,607 selenocysteine biosynthetic process [GO:0016260]; selenocysteine incorporation [GO:0001514]; selenocysteinyl-tRNA(Sec) biosynthetic process [GO:0097056] cytosol [GO:0005829] cytosol [GO:0005829]; identical protein binding [GO:0042802]; L-seryl-tRNASec selenium transferase activity [GO:0004125]; pyridoxal phosphate binding [GO:0030170]; selenocysteine biosynthetic process [GO:0016260]; selenocysteine incorporation [GO:0001514]; selenocysteinyl-tRNA(Sec) biosynthetic process [GO:0097056] identical protein binding [GO:0042802]; L-seryl-tRNASec selenium transferase activity [GO:0004125]; pyridoxal phosphate binding [GO:0030170] GO:0001514; GO:0004125; GO:0005829; GO:0016260; GO:0030170; GO:0042802; GO:0097056 SUBCELLULAR LOCATION: Cytoplasm. +P38052 SFMF_ECOLI Uncharacterized fimbrial-like protein SfmF sfmF ybcG b0534 JW5072 ybcG sfmF 18,223 cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0007155; GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}. +P0AG14 SOHB_ECOLI Probable protease SohB (EC 3.4.21.-) sohB b1272 JW1264 sohB 39,366 proteolysis [GO:0006508] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508] serine-type endopeptidase activity [GO:0004252] GO:0004252; GO:0005886; GO:0006508; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein. +P0A828 SMG_ECOLI Protein Smg smg b3284 JW3245 smg 18,510 +P39362 SGCE_ECOLI Protein SgcE (EC 5.1.3.-) sgcE yjhK b4301 JW4263 yjhK sgcE 23,214 cellular carbohydrate metabolic process [GO:0044262]; pentose catabolic process [GO:0019323]; pentose-phosphate shunt, non-oxidative branch [GO:0009052] cytosol [GO:0005829] cytosol [GO:0005829]; metal ion binding [GO:0046872]; ribulose-phosphate 3-epimerase activity [GO:0004750]; cellular carbohydrate metabolic process [GO:0044262]; pentose catabolic process [GO:0019323]; pentose-phosphate shunt, non-oxidative branch [GO:0009052] metal ion binding [GO:0046872]; ribulose-phosphate 3-epimerase activity [GO:0004750] GO:0004750; GO:0005829; GO:0009052; GO:0019323; GO:0044262; GO:0046872 +P15082 SRLR_ECOLI Glucitol operon repressor srlR gutR b2707 JW2676 gutR srlR 28,236 negative regulation of transcription, DNA-templated [GO:0045892]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0009401; GO:0045892 +P0AFH8 OSMY_ECOLI Osmotically-inducible protein Y osmY b4376 JW4338 osmY 21,074 chaperone-mediated protein folding [GO:0061077]; hyperosmotic response [GO:0006972]; response to osmotic stress [GO:0006970] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; chaperone-mediated protein folding [GO:0061077]; hyperosmotic response [GO:0006972]; response to osmotic stress [GO:0006970] GO:0006970; GO:0006972; GO:0030288; GO:0061077 SUBCELLULAR LOCATION: Periplasm. +P09169 OMPT_ECOLI Protease 7 (EC 3.4.23.49) (Omptin) (Outer membrane protein 3B) (Protease A) (Protease VII) ompT b0565 JW0554 ompT 35,562 proteolysis [GO:0006508] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; intrinsic component of cell outer membrane [GO:0031230] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; intrinsic component of cell outer membrane [GO:0031230]; aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508] aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252] GO:0004175; GO:0004190; GO:0004252; GO:0006508; GO:0009279; GO:0016021; GO:0031230 SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein. +P36672 PTTBC_ECOLI PTS system trehalose-specific EIIBC component (EIIBC-Tre) (EII-Tre) [Includes: Trehalose-specific phosphotransferase enzyme IIB component (EC 2.7.1.201) (PTS system trehalose-specific EIIB component); Trehalose permease IIC component (PTS system trehalose-specific EIIC component)] treB b4240 JW4199 treB 51,081 carbohydrate transmembrane transport [GO:0034219]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; trehalose transport [GO:0015771] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; protein-phosphocysteine-trehalose phosphotransferase system transporter activity [GO:0090589]; trehalose transmembrane transporter activity [GO:0015574]; carbohydrate transmembrane transport [GO:0034219]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; trehalose transport [GO:0015771] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; protein-phosphocysteine-trehalose phosphotransferase system transporter activity [GO:0090589]; trehalose transmembrane transporter activity [GO:0015574] GO:0005886; GO:0008982; GO:0009401; GO:0015574; GO:0015771; GO:0016021; GO:0016301; GO:0034219; GO:0090563; GO:0090589 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00426, ECO:0000305|PubMed:2160944}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00426}. +P33024 PSUT_ECOLI Putative pseudouridine transporter psuT pscT yeiM b2164 JW2151 pscT yeiM psuT 43,432 nucleoside transmembrane transport [GO:1901642] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; nucleoside transmembrane transporter activity [GO:0005337]; symporter activity [GO:0015293]; nucleoside transmembrane transport [GO:1901642] nucleoside transmembrane transporter activity [GO:0005337]; symporter activity [GO:0015293] GO:0005337; GO:0005886; GO:0005887; GO:0015293; GO:1901642 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P37188 PTKB_ECOLI PTS system galactitol-specific EIIB component (EIIB-Gat) (Galactitol-specific phosphotransferase enzyme IIB component) (EC 2.7.1.200) gatB b2093 JW2077 gatB 10,222 galactitol metabolic process [GO:0019402]; galactitol transport [GO:0015796]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytosol [GO:0005829] cytosol [GO:0005829]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-galactitol-phosphotransferase system transporter activity [GO:0090584]; galactitol metabolic process [GO:0019402]; galactitol transport [GO:0015796]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-galactitol-phosphotransferase system transporter activity [GO:0090584] GO:0005829; GO:0008982; GO:0009401; GO:0015796; GO:0019402; GO:0090584 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:8955298}. +P56580 PTHB_ECOLI PTS system glucitol/sorbitol-specific EIIB component (EC 2.7.1.198) (EII-Gut) (Enzyme II-Gut) (Glucitol/sorbitol-specific phosphotransferase enzyme IIB component) srlE gutA gutE b2703 JW5430 gutA gutE srlE 33,332 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005886; GO:0008982; GO:0009401; GO:0016021; GO:0016301; GO:0090563 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:3553176}; Multi-pass membrane protein {ECO:0000255, ECO:0000305|PubMed:3553176}. +P04983 RBSA_ECOLI Ribose import ATP-binding protein RbsA (EC 7.5.2.7) rbsA b3749 JW3728 rbsA 55,042 D-ribose transmembrane transport [GO:0015752] ATP-binding cassette (ABC) transporter complex [GO:0043190] ATP-binding cassette (ABC) transporter complex [GO:0043190]; ABC-type D-ribose transporter activity [GO:0015611]; ABC-type monosaccharide transporter activity [GO:0015407]; ATP binding [GO:0005524]; D-ribose transmembrane transporter activity [GO:0015591]; D-ribose transmembrane transport [GO:0015752] ABC-type D-ribose transporter activity [GO:0015611]; ABC-type monosaccharide transporter activity [GO:0015407]; ATP binding [GO:0005524]; D-ribose transmembrane transporter activity [GO:0015591] GO:0005524; GO:0015407; GO:0015591; GO:0015611; GO:0015752; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01716, ECO:0000305|PubMed:25533465}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01716, ECO:0000305|PubMed:25533465}. +P0C079 RELB_ECOLI Antitoxin RelB relB b1564 JW1556 relB 9,071 transcription, DNA-templated [GO:0006351] protein-DNA complex [GO:0032993] protein-DNA complex [GO:0032993]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription repressor activity [GO:0001217]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; transcription, DNA-templated [GO:0006351] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription repressor activity [GO:0001217]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0000986; GO:0001217; GO:0006351; GO:0032993 +P75782 RLMF_ECOLI Ribosomal RNA large subunit methyltransferase F (EC 2.1.1.181) (23S rRNA mA1618 methyltransferase) (rRNA adenine N-6-methyltransferase) rlmF ybiN b0807 JW5107 ybiN rlmF 34,226 rRNA base methylation [GO:0070475] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 23S rRNA (adenine(1618)-N(6))-methyltransferase activity [GO:0052907]; rRNA base methylation [GO:0070475] 23S rRNA (adenine(1618)-N(6))-methyltransferase activity [GO:0052907] GO:0005737; GO:0052907; GO:0070475 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P31667 RPNA_ECOLI Recombination-promoting nuclease RpnA (EC 3.1.21.-) rpnA yhgA b3411 JW3374 yhgA rpnA 33,267 DNA recombination [GO:0006310] double-stranded DNA endodeoxyribonuclease activity [GO:1990238]; endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888]; DNA recombination [GO:0006310] double-stranded DNA endodeoxyribonuclease activity [GO:1990238]; endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888] GO:0006310; GO:0016888; GO:1990238 +P0A776 RPPH_ECOLI RNA pyrophosphohydrolase (EC 3.6.1.-) ((Di)nucleoside polyphosphate hydrolase) (Ap5A pyrophosphatase) rppH nudH ygdP b2830 JW2798 nudH ygdP rppH 20,795 mRNA catabolic process [GO:0006402]; NAD-cap decapping [GO:0110155]; RNA decapping [GO:0110154]; RNA destabilization [GO:0050779]; tRNA processing [GO:0008033] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; magnesium ion binding [GO:0000287]; RNA NAD-cap (NMN-forming) hydrolase activity [GO:0110153]; RNA pyrophosphohydrolase activity [GO:0034353]; mRNA catabolic process [GO:0006402]; NAD-cap decapping [GO:0110155]; RNA decapping [GO:0110154]; RNA destabilization [GO:0050779]; tRNA processing [GO:0008033] hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; magnesium ion binding [GO:0000287]; RNA NAD-cap (NMN-forming) hydrolase activity [GO:0110153]; RNA pyrophosphohydrolase activity [GO:0034353] GO:0000287; GO:0005737; GO:0006402; GO:0008033; GO:0016818; GO:0034353; GO:0050779; GO:0110153; GO:0110154; GO:0110155 +P0AG96 SECE_ECOLI Protein translocase subunit SecE secE prlG b3981 JW3944 prlG secE 13,643 intracellular protein transmembrane transport [GO:0065002]; intracellular protein transport [GO:0006886]; protein insertion into membrane from inner side [GO:0032978]; protein secretion [GO:0009306]; protein transport by the Sec complex [GO:0043952]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616] cell envelope Sec protein transport complex [GO:0031522]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cell envelope Sec protein transport complex [GO:0031522]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; P-P-bond-hydrolysis-driven protein transmembrane transporter activity [GO:0015450]; protein transmembrane transporter activity [GO:0008320]; intracellular protein transmembrane transport [GO:0065002]; intracellular protein transport [GO:0006886]; protein insertion into membrane from inner side [GO:0032978]; protein secretion [GO:0009306]; protein transport by the Sec complex [GO:0043952]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616] P-P-bond-hydrolysis-driven protein transmembrane transporter activity [GO:0015450]; protein transmembrane transporter activity [GO:0008320] GO:0005886; GO:0005887; GO:0006616; GO:0006886; GO:0008320; GO:0009306; GO:0015450; GO:0016021; GO:0031522; GO:0032978; GO:0043952; GO:0065002 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00422, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00422, ECO:0000269|PubMed:15919996}. +P64559 SDHE_ECOLI FAD assembly factor SdhE (Antitoxin CptB) sdhE cptB ygfY b2897 JW2865 cptB ygfY sdhE 10,547 protein flavinylation [GO:0017013]; respiratory chain complex II assembly [GO:0034552]; succinate metabolic process [GO:0006105] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; protein flavinylation [GO:0017013]; respiratory chain complex II assembly [GO:0034552]; succinate metabolic process [GO:0006105] GO:0005737; GO:0006105; GO:0017013; GO:0034552 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:G4V4G2}. +P0AFY8 SEQA_ECOLI Negative modulator of initiation of replication seqA b0687 JW0674 seqA 20,315 negative regulation of DNA-dependent DNA replication initiation [GO:0032297]; nucleoid organization [GO:0090143]; regulation of transcription, DNA-templated [GO:0006355]; response to radiation [GO:0009314]; sister chromatid cohesion [GO:0007062] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; SeqA-DNA complex [GO:1990097] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; SeqA-DNA complex [GO:1990097]; DNA replication origin binding [GO:0003688]; double-stranded methylated DNA binding [GO:0010385]; hemi-methylated DNA-binding [GO:0044729]; identical protein binding [GO:0042802]; negative regulation of DNA-dependent DNA replication initiation [GO:0032297]; nucleoid organization [GO:0090143]; regulation of transcription, DNA-templated [GO:0006355]; response to radiation [GO:0009314]; sister chromatid cohesion [GO:0007062] DNA replication origin binding [GO:0003688]; double-stranded methylated DNA binding [GO:0010385]; hemi-methylated DNA-binding [GO:0044729]; identical protein binding [GO:0042802] GO:0003688; GO:0005829; GO:0006355; GO:0007062; GO:0009314; GO:0010385; GO:0032297; GO:0032991; GO:0042802; GO:0044729; GO:0090143; GO:1990097 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00908, ECO:0000269|PubMed:9660922}. Note=Localization is cell cycle-dependent. Localizes at midcell in newborn cells, then migrates in opposite directions toward cell quarter sites and remains tethered there until the cell divides. +P0ACG1 STPA_ECOLI DNA-binding protein StpA (H-NS homolog StpA) stpA hnsB b2669 JW2644 hnsB stpA 15,348 gene silencing [GO:0016458] cytosol [GO:0005829]; nucleoid [GO:0009295]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; nucleoid [GO:0009295]; protein-DNA complex [GO:0032993]; bent DNA binding [GO:0003681]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity [GO:0001217]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein dimerization activity [GO:0046983]; RNA binding [GO:0003723]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; gene silencing [GO:0016458] bent DNA binding [GO:0003681]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity [GO:0001217]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein dimerization activity [GO:0046983]; RNA binding [GO:0003723]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0001217; GO:0003677; GO:0003680; GO:0003681; GO:0003723; GO:0005829; GO:0009295; GO:0016458; GO:0032993; GO:0046983 SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000269|PubMed:21903814}. Note=Scattered throughout the nucleoid (PubMed:21903814). {ECO:0000269|PubMed:21903814}. +P0AA47 PLAP_ECOLI Low-affinity putrescine importer PlaP plaP yeeF b2014 JW5330 yeeF plaP 49,538 amino acid transport [GO:0006865]; cell motility [GO:0048870]; putrescine transport [GO:0015847] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; putrescine transmembrane transporter activity [GO:0015489]; solute:proton symporter activity [GO:0015295]; amino acid transport [GO:0006865]; cell motility [GO:0048870]; putrescine transport [GO:0015847] putrescine transmembrane transporter activity [GO:0015489]; solute:proton symporter activity [GO:0015295] GO:0005886; GO:0006865; GO:0015295; GO:0015489; GO:0015847; GO:0016021; GO:0048870 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P08722 PTV3B_ECOLI PTS system beta-glucoside-specific EIIBCA component (EIIBCA-Bgl) (EII-Bgl) [Includes: Beta-glucoside-specific phosphotransferase enzyme IIB component (EC 2.7.1.-) (PTS system beta-glucoside-specific EIIB component); Beta-glucoside permease IIC component (PTS system beta-glucoside-specific EIIC component); Beta-glucoside-specific phosphotransferase enzyme IIA component (PTS system beta-glucoside-specific EIIA component)] bglF bglC bglS b3722 JW3700 bglC bglS bglF 66,483 carbohydrate transmembrane transport [GO:0034219]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; trehalose transport [GO:0015771] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; protein-phosphocysteine-trehalose phosphotransferase system transporter activity [GO:0090589]; carbohydrate transmembrane transport [GO:0034219]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; trehalose transport [GO:0015771] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; protein-phosphocysteine-trehalose phosphotransferase system transporter activity [GO:0090589] GO:0005886; GO:0008982; GO:0009401; GO:0015771; GO:0016021; GO:0016301; GO:0034219; GO:0090563; GO:0090589 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P60624 RL24_ECOLI 50S ribosomal protein L24 (Large ribosomal subunit protein uL24) rplX b3309 JW3271 rplX 11,316 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735] GO:0000027; GO:0003735; GO:0005829; GO:0006412; GO:0022625; GO:0070180 +P0A7M2 RL28_ECOLI 50S ribosomal protein L28 (Large ribosomal subunit protein bL28) rpmB b3637 JW3612 rpmB 9,006 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GO:0000027; GO:0003735; GO:0005829; GO:0006412; GO:0019843; GO:0022625 +P0A8T7 RPOC_ECOLI DNA-directed RNA polymerase subunit beta' (RNAP subunit beta') (EC 2.7.7.6) (RNA polymerase subunit beta') (Transcriptase subunit beta') rpoC tabB b3988 JW3951 tabB rpoC 155,160 response to antibiotic [GO:0046677]; transcription, DNA-templated [GO:0006351] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270]; response to antibiotic [GO:0046677]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270] GO:0000287; GO:0003677; GO:0003899; GO:0005737; GO:0005829; GO:0006351; GO:0008270; GO:0016020; GO:0046677 +P0A8V2 RPOB_ECOLI DNA-directed RNA polymerase subunit beta (RNAP subunit beta) (EC 2.7.7.6) (RNA polymerase subunit beta) (Transcriptase subunit beta) rpoB groN nitB rif ron stl stv tabD b3987 JW3950 groN nitB rif ron stl stv tabD rpoB 150,632 response to antibiotic [GO:0046677]; transcription, DNA-templated [GO:0006351] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; ribonucleoside binding [GO:0032549]; response to antibiotic [GO:0046677]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; ribonucleoside binding [GO:0032549] GO:0003677; GO:0003899; GO:0005737; GO:0005829; GO:0006351; GO:0016020; GO:0032549; GO:0046677 +P0ACU2 RUTR_ECOLI HTH-type transcriptional regulator RutR (Rut operon repressor) rutR ycdC b1013 JW0998 ycdC rutR 23,688 negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355; GO:0045892; GO:0045893 +P07014 SDHB_ECOLI Succinate dehydrogenase iron-sulfur subunit (EC 1.3.5.1) sdhB b0724 JW0714 sdhB 26,770 aerobic respiration [GO:0009060]; respiratory electron transport chain [GO:0022904]; tricarboxylic acid cycle [GO:0006099] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; 2 iron, 2 sulfur cluster binding [GO:0051537]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; succinate dehydrogenase (ubiquinone) activity [GO:0008177]; aerobic respiration [GO:0009060]; respiratory electron transport chain [GO:0022904]; tricarboxylic acid cycle [GO:0006099] 2 iron, 2 sulfur cluster binding [GO:0051537]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; succinate dehydrogenase (ubiquinone) activity [GO:0008177] GO:0005886; GO:0006099; GO:0008177; GO:0009055; GO:0009060; GO:0022904; GO:0046872; GO:0051536; GO:0051537; GO:0051538; GO:0051539 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000269|PubMed:16079137}. +P0A840 SURE_ECOLI 5'/3'-nucleotidase SurE (EC 3.1.3.5) (EC 3.1.3.6) (Exopolyphosphatase) (EC 3.6.1.11) (Nucleoside monophosphate phosphohydrolase) (Stationary-phase survival protein SurE) surE ygbC b2744 JW2714 ygbC surE 26,900 UMP catabolic process [GO:0046050] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 3'-nucleotidase activity [GO:0008254]; 5'-nucleotidase activity [GO:0008253]; exopolyphosphatase activity [GO:0004309]; manganese ion binding [GO:0030145]; nucleotide binding [GO:0000166]; UMP catabolic process [GO:0046050] 3'-nucleotidase activity [GO:0008254]; 5'-nucleotidase activity [GO:0008253]; exopolyphosphatase activity [GO:0004309]; manganese ion binding [GO:0030145]; nucleotide binding [GO:0000166] GO:0000166; GO:0004309; GO:0005737; GO:0008253; GO:0008254; GO:0030145; GO:0046050 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P08312 SYFA_ECOLI Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) pheS b1714 JW5277 pheS 36,832 phenylalanyl-tRNA aminoacylation [GO:0006432] cytoplasm [GO:0005737]; cytosol [GO:0005829]; phenylalanine-tRNA ligase complex [GO:0009328] cytoplasm [GO:0005737]; cytosol [GO:0005829]; phenylalanine-tRNA ligase complex [GO:0009328]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; tRNA binding [GO:0000049]; phenylalanyl-tRNA aminoacylation [GO:0006432] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; tRNA binding [GO:0000049] GO:0000049; GO:0000287; GO:0004826; GO:0005524; GO:0005737; GO:0005829; GO:0006432; GO:0009328 SUBCELLULAR LOCATION: Cytoplasm. +P76423 THIM_ECOLI Hydroxyethylthiazole kinase (EC 2.7.1.50) (4-methyl-5-beta-hydroxyethylthiazole kinase) (TH kinase) (Thz kinase) thiM b2104 JW2091 thiM 27,339 thiamine diphosphate biosynthetic process [GO:0009229]; thiamine salvage [GO:0036172] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; hydroxyethylthiazole kinase activity [GO:0004417]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; prenol kinase activity [GO:0052673]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine salvage [GO:0036172] ATP binding [GO:0005524]; hydroxyethylthiazole kinase activity [GO:0004417]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; prenol kinase activity [GO:0052673] GO:0000287; GO:0004417; GO:0005524; GO:0005829; GO:0009229; GO:0036172; GO:0042802; GO:0052673 +P0A7X3 RS9_ECOLI 30S ribosomal protein S9 (Small ribosomal subunit protein uS9) rpsI b3230 JW3199 rpsI 14,856 translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049]; translation [GO:0006412] RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049] GO:0000049; GO:0003723; GO:0003735; GO:0005829; GO:0006412; GO:0015935; GO:0022627 +P0AFX4 RSD_ECOLI Regulator of sigma D rsd b3995 JW3959 rsd 18,243 cytoplasm [GO:0005737] cytoplasm [GO:0005737]; sigma factor antagonist activity [GO:0016989] sigma factor antagonist activity [GO:0016989] GO:0005737; GO:0016989 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01181}. +P75893 RUTF_ECOLI FMN reductase (NADH) RutF (EC 1.5.1.42) (FMN reductase) (NADH-flavin reductase RutF) (NADH:flavin oxidoreductase) rutF ycdH b1007 JW5138 ycdH rutF 17,749 nitrogen utilization [GO:0019740]; pyrimidine nucleobase catabolic process [GO:0006208]; uracil catabolic process [GO:0006212] FMN binding [GO:0010181]; FMN reductase (NADH) activity [GO:0052874]; FMN reductase activity [GO:0008752]; riboflavin reductase (NADPH) activity [GO:0042602]; nitrogen utilization [GO:0019740]; pyrimidine nucleobase catabolic process [GO:0006208]; uracil catabolic process [GO:0006212] FMN binding [GO:0010181]; FMN reductase (NADH) activity [GO:0052874]; FMN reductase activity [GO:0008752]; riboflavin reductase (NADPH) activity [GO:0042602] GO:0006208; GO:0006212; GO:0008752; GO:0010181; GO:0019740; GO:0042602; GO:0052874 +P0ACM2 RSPR_ECOLI HTH-type transcriptional repressor RspR rspR ydfH b1540 JW1533 ydfH rspR 26,565 DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700 +P18392 RSTB_ECOLI Sensor protein RstB (EC 2.7.13.3) rstB uspT b1609 JW1601 uspT rstB 49,283 peptidyl-histidine phosphorylation [GO:0018106]; protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; peptidyl-histidine phosphorylation [GO:0018106]; protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165] ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155] GO:0000155; GO:0005524; GO:0005886; GO:0005887; GO:0007165; GO:0018106; GO:0046777 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76273 RSMF_ECOLI Ribosomal RNA small subunit methyltransferase F (EC 2.1.1.178) (16S rRNA m5C1407 methyltransferase) (rRNA (cytosine-C(5)-)-methyltransferase RsmF) rsmF yebU b1835 JW5301 yebU rsmF 53,228 RNA methylation [GO:0001510]; rRNA base methylation [GO:0070475] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; RNA binding [GO:0003723]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383]; RNA methylation [GO:0001510]; rRNA base methylation [GO:0070475] RNA binding [GO:0003723]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383] GO:0001510; GO:0003723; GO:0005737; GO:0009383; GO:0070475 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P33018 SFGH2_ECOLI S-formylglutathione hydrolase YeiG (FGH) (EC 3.1.2.12) yeiG b2154 JW2141 yeiG 31,259 formaldehyde catabolic process [GO:0046294]; protein homotetramerization [GO:0051289] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; carboxylic ester hydrolase activity [GO:0052689]; hydroxyacylglutathione hydrolase activity [GO:0004416]; identical protein binding [GO:0042802]; S-formylglutathione hydrolase activity [GO:0018738]; formaldehyde catabolic process [GO:0046294]; protein homotetramerization [GO:0051289] carboxylic ester hydrolase activity [GO:0052689]; hydroxyacylglutathione hydrolase activity [GO:0004416]; identical protein binding [GO:0042802]; S-formylglutathione hydrolase activity [GO:0018738] GO:0004416; GO:0005829; GO:0018738; GO:0032991; GO:0042802; GO:0046294; GO:0051289; GO:0052689 +P00961 SYGB_ECOLI Glycine--tRNA ligase beta subunit (EC 6.1.1.14) (Glycyl-tRNA synthetase beta subunit) (GlyRS) glyS glyS(B) b3559 JW3530 glyS(B) glyS 76,813 arginyl-tRNA aminoacylation [GO:0006420]; glycyl-tRNA aminoacylation [GO:0006426] cytosol [GO:0005829] cytosol [GO:0005829]; arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; glycine-tRNA ligase activity [GO:0004820]; arginyl-tRNA aminoacylation [GO:0006420]; glycyl-tRNA aminoacylation [GO:0006426] arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; glycine-tRNA ligase activity [GO:0004820] GO:0004814; GO:0004820; GO:0005524; GO:0005829; GO:0006420; GO:0006426 SUBCELLULAR LOCATION: Cytoplasm. +P76422 THID_ECOLI Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC 2.7.1.49) (EC 2.7.4.7) (Hydroxymethylpyrimidine kinase) (HMP kinase) (Hydroxymethylpyrimidine phosphate kinase) (HMP-P kinase) (HMP-phosphate kinase) (HMPP kinase) thiD thiJ b2103 JW2090 thiJ thiD 28,634 phosphorylation [GO:0016310]; thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; hydroxymethylpyrimidine kinase activity [GO:0008902]; phosphomethylpyrimidine kinase activity [GO:0008972]; phosphorylation [GO:0016310]; thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] ATP binding [GO:0005524]; hydroxymethylpyrimidine kinase activity [GO:0008902]; phosphomethylpyrimidine kinase activity [GO:0008972] GO:0005524; GO:0005829; GO:0008902; GO:0008972; GO:0009228; GO:0009229; GO:0016310 +P77163 TFAR_ECOLI Prophage tail fiber assembly protein homolog TfaR (Tail fiber assembly protein homolog from lambdoid prophage Rac) tfaR ynaC b1373 JW1367 ynaC tfaR 21,337 +P62601 TREF_ECOLI Cytoplasmic trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase) treF b3519 JW3487 treF 63,697 cellular hyperosmotic response [GO:0071474]; trehalose catabolic process [GO:0005993] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; alpha,alpha-trehalase activity [GO:0004555]; cellular hyperosmotic response [GO:0071474]; trehalose catabolic process [GO:0005993] alpha,alpha-trehalase activity [GO:0004555] GO:0004555; GO:0005737; GO:0005993; GO:0071474 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01059, ECO:0000269|PubMed:10816581}. +P0ABU9 TOLQ_ECOLI Tol-Pal system protein TolQ tolQ fii b0737 JW0727 fii tolQ 25,598 bacteriocin transport [GO:0043213]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein import [GO:0017038] cell division site [GO:0032153]; cell envelope [GO:0030313]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cell division site [GO:0032153]; cell envelope [GO:0030313]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; bacteriocin transport [GO:0043213]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein import [GO:0017038] GO:0005886; GO:0005887; GO:0007049; GO:0016021; GO:0017038; GO:0030313; GO:0032153; GO:0043213; GO:0051301 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02202, ECO:0000269|PubMed:8300535, ECO:0000269|PubMed:8331075}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02202, ECO:0000269|PubMed:8300535, ECO:0000305|PubMed:8331075}. Note=Accumulates at cell constriction sites. Recruitment to the division site is dependent on FtsN activity. {ECO:0000269|PubMed:17233825}. +P02930 TOLC_ECOLI Outer membrane protein TolC (Multidrug efflux pump subunit TolC) (Outer membrane factor TolC) tolC colE1-i mtcB mukA refI toc weeA b3035 JW5503 colE1-i mtcB mukA refI toc weeA tolC 53,741 bile acid and bile salt transport [GO:0015721]; enterobactin transport [GO:0042930]; ion transmembrane transport [GO:0034220]; response to antibiotic [GO:0046677]; response to drug [GO:0042493]; response to organic cyclic compound [GO:0014070]; response to toxic substance [GO:0009636] cell outer membrane [GO:0009279]; efflux pump complex [GO:1990281]; integral component of cell outer membrane [GO:0045203]; integral component of membrane [GO:0016021]; MacAB-TolC complex [GO:1990196]; outer membrane-bounded periplasmic space [GO:0030288] cell outer membrane [GO:0009279]; efflux pump complex [GO:1990281]; integral component of cell outer membrane [GO:0045203]; integral component of membrane [GO:0016021]; MacAB-TolC complex [GO:1990196]; outer membrane-bounded periplasmic space [GO:0030288]; bile acid transmembrane transporter activity [GO:0015125]; efflux transmembrane transporter activity [GO:0015562]; identical protein binding [GO:0042802]; ion channel activity [GO:0005216]; porin activity [GO:0015288]; protein N-terminus binding [GO:0047485]; bile acid and bile salt transport [GO:0015721]; enterobactin transport [GO:0042930]; ion transmembrane transport [GO:0034220]; response to antibiotic [GO:0046677]; response to drug [GO:0042493]; response to organic cyclic compound [GO:0014070]; response to toxic substance [GO:0009636] bile acid transmembrane transporter activity [GO:0015125]; efflux transmembrane transporter activity [GO:0015562]; identical protein binding [GO:0042802]; ion channel activity [GO:0005216]; porin activity [GO:0015288]; protein N-terminus binding [GO:0047485] GO:0005216; GO:0009279; GO:0009636; GO:0014070; GO:0015125; GO:0015288; GO:0015562; GO:0015721; GO:0016021; GO:0030288; GO:0034220; GO:0042493; GO:0042802; GO:0042930; GO:0045203; GO:0046677; GO:0047485; GO:1990196; GO:1990281 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:21778229, ECO:0000269|PubMed:6337123, ECO:0000269|PubMed:9044294}; Multi-pass membrane protein {ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:21778229, ECO:0000269|PubMed:6337123, ECO:0000269|PubMed:9044294}. +P76403 TRHP_ECOLI tRNA hydroxylation protein P (EC 3.4.-.-) trhP yegQ b2081 JW2066 yegQ trhP 51,193 tRNA modification [GO:0006400]; tRNA wobble uridine modification [GO:0002098] cytosol [GO:0005829] cytosol [GO:0005829]; peptidase activity [GO:0008233]; tRNA modification [GO:0006400]; tRNA wobble uridine modification [GO:0002098] peptidase activity [GO:0008233] GO:0002098; GO:0005829; GO:0006400; GO:0008233 +P05847 TTDA_ECOLI L(+)-tartrate dehydratase subunit alpha (L-TTD alpha) (EC 4.2.1.32) ttdA ygjA b3061 JW3033 ygjA ttdA 32,734 tartrate metabolic process [GO:1901275] 4 iron, 4 sulfur cluster binding [GO:0051539]; L(+)-tartrate dehydratase activity [GO:0008730]; metal ion binding [GO:0046872]; tartrate metabolic process [GO:1901275] 4 iron, 4 sulfur cluster binding [GO:0051539]; L(+)-tartrate dehydratase activity [GO:0008730]; metal ion binding [GO:0046872] GO:0008730; GO:0046872; GO:0051539; GO:1901275 +P33021 NUPX_ECOLI Putative nucleoside permease NupX nupX yeiJ b2161 JW2148 yeiJ nupX 43,410 nucleoside transmembrane transport [GO:1901642] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; nucleoside transmembrane transporter activity [GO:0005337]; symporter activity [GO:0015293]; nucleoside transmembrane transport [GO:1901642] nucleoside transmembrane transporter activity [GO:0005337]; symporter activity [GO:0015293] GO:0005337; GO:0005886; GO:0005887; GO:0015293; GO:1901642 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P16690 PHNN_ECOLI Ribose 1,5-bisphosphate phosphokinase PhnN (EC 2.7.4.23) (Ribose 1,5-bisphosphokinase) phnN b4094 JW4055 phnN 20,730 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; NAD biosynthetic process [GO:0009435]; organic phosphonate metabolic process [GO:0019634] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; ribose 1,5-bisphosphate phosphokinase activity [GO:0033863]; 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; NAD biosynthetic process [GO:0009435]; organic phosphonate metabolic process [GO:0019634] ATP binding [GO:0005524]; ribose 1,5-bisphosphate phosphokinase activity [GO:0033863] GO:0005524; GO:0005829; GO:0006015; GO:0009435; GO:0019634; GO:0033863 +P45548 PHP_ECOLI Phosphotriesterase homology protein (EC 3.1.-.-) php yhfV b3379 JW3342 yhfV php 32,915 catabolic process [GO:0009056] hydrolase activity, acting on ester bonds [GO:0016788]; zinc ion binding [GO:0008270]; catabolic process [GO:0009056] hydrolase activity, acting on ester bonds [GO:0016788]; zinc ion binding [GO:0008270] GO:0008270; GO:0009056; GO:0016788 +P29745 PEPT_ECOLI Peptidase T (EC 3.4.11.4) (Aminotripeptidase) (Tripeptidase) (Tripeptide aminopeptidase) pepT b1127 JW1113 pepT 44,923 peptide catabolic process [GO:0043171]; peptide metabolic process [GO:0006518] cytosol [GO:0005829] cytosol [GO:0005829]; metallopeptidase activity [GO:0008237]; tripeptide aminopeptidase activity [GO:0045148]; zinc ion binding [GO:0008270]; peptide catabolic process [GO:0043171]; peptide metabolic process [GO:0006518] metallopeptidase activity [GO:0008237]; tripeptide aminopeptidase activity [GO:0045148]; zinc ion binding [GO:0008270] GO:0005829; GO:0006518; GO:0008237; GO:0008270; GO:0043171; GO:0045148 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P0ADY3 RL14_ECOLI 50S ribosomal protein L14 (Large ribosomal subunit protein uL14) rplN b3310 JW3272 rplN 13,541 translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412] large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735] GO:0003735; GO:0005829; GO:0006412; GO:0022625; GO:0070180 +P37745 RMLC_ECOLI dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) (Thymidine diphospho-4-keto-rhamnose 3,5-epimerase) (dTDP-4-keto-6-deoxyglucose 3,5-epimerase) (dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase) (dTDP-L-rhamnose synthase) rfbC rmlC b2038 JW2023 rmlC rfbC 21,270 cellular response to DNA damage stimulus [GO:0006974]; dTDP-rhamnose biosynthetic process [GO:0019305]; extracellular polysaccharide biosynthetic process [GO:0045226]; lipopolysaccharide biosynthetic process [GO:0009103]; O antigen biosynthetic process [GO:0009243]; response to antibiotic [GO:0046677]; response to UV [GO:0009411] cytosol [GO:0005829] cytosol [GO:0005829]; dTDP-4-dehydrorhamnose 3,5-epimerase activity [GO:0008830]; cellular response to DNA damage stimulus [GO:0006974]; dTDP-rhamnose biosynthetic process [GO:0019305]; extracellular polysaccharide biosynthetic process [GO:0045226]; lipopolysaccharide biosynthetic process [GO:0009103]; O antigen biosynthetic process [GO:0009243]; response to antibiotic [GO:0046677]; response to UV [GO:0009411] dTDP-4-dehydrorhamnose 3,5-epimerase activity [GO:0008830] GO:0005829; GO:0006974; GO:0008830; GO:0009103; GO:0009243; GO:0009411; GO:0019305; GO:0045226; GO:0046677 +P52130 RNLB_ECOLI Antitoxin RnlB rnlB yfjO b2631 JW5418 yfjO rnlB 13,665 negative regulation of endoribonuclease activity [GO:0060702] negative regulation of endoribonuclease activity [GO:0060702] GO:0060702 +P76149 SAD_ECOLI Succinate semialdehyde dehydrogenase [NAD(P)+] Sad (SSADH) (SSDH) (EC 1.2.1.16) sad yneI b1525 JW5247 yneI sad 49,718 arginine catabolic process [GO:0006527]; gamma-aminobutyric acid catabolic process [GO:0009450]; nitrogen compound metabolic process [GO:0006807]; putrescine catabolic process [GO:0009447] aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777]; succinate-semialdehyde dehydrogenase (NADP+) activity [GO:0036243]; succinate-semialdehyde dehydrogenase [NAD(P)+] activity [GO:0009013]; arginine catabolic process [GO:0006527]; gamma-aminobutyric acid catabolic process [GO:0009450]; nitrogen compound metabolic process [GO:0006807]; putrescine catabolic process [GO:0009447] aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777]; succinate-semialdehyde dehydrogenase (NADP+) activity [GO:0036243]; succinate-semialdehyde dehydrogenase [NAD(P)+] activity [GO:0009013] GO:0004030; GO:0004777; GO:0006527; GO:0006807; GO:0009013; GO:0009447; GO:0009450; GO:0036243 +P0A823 SFSA_ECOLI Sugar fermentation stimulation protein A sfsA sfs1 b0146 JW0142 sfs1 sfsA 26,229 positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677] GO:0003677; GO:0006355; GO:0045893 +P0AGM5 SIRB1_ECOLI UPF0162 protein YchA (Protein SirB1) ychA sirB1 b1214 JW1205 sirB1 ychA 30,841 +P76145 TAM_ECOLI Trans-aconitate 2-methyltransferase (EC 2.1.1.144) tam yneD b1519 JW1512 yneD tam 29,006 methylation [GO:0032259] cytosol [GO:0005829] cytosol [GO:0005829]; trans-aconitate 2-methyltransferase activity [GO:0030798]; methylation [GO:0032259] trans-aconitate 2-methyltransferase activity [GO:0030798] GO:0005829; GO:0030798; GO:0032259 SUBCELLULAR LOCATION: Cytoplasm. +P0A6Q6 FABZ_ECOLI 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ (EC 4.2.1.59) ((3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase) ((3R)-hydroxymyristoyl-ACP dehydrase) (17 kDa actomyosin component) (Beta-hydroxyacyl-ACP dehydratase) fabZ sefA yaeA b0180 JW0175 sefA yaeA fabZ 17,033 fatty acid biosynthetic process [GO:0006633]; lipid A biosynthetic process [GO:0009245] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity [GO:0008659]; 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity [GO:0008693]; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity [GO:0047451]; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity [GO:0004317]; identical protein binding [GO:0042802]; fatty acid biosynthetic process [GO:0006633]; lipid A biosynthetic process [GO:0009245] (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity [GO:0008659]; 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity [GO:0008693]; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity [GO:0047451]; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity [GO:0004317]; identical protein binding [GO:0042802] GO:0004317; GO:0005737; GO:0006633; GO:0008659; GO:0008693; GO:0009245; GO:0042802; GO:0047451 SUBCELLULAR LOCATION: Cytoplasm. +P76555 EUTQ_ECOLI Acetate kinase EutQ (EC 2.7.2.1) (Ethanolamine utilization protein EutQ) eutQ ypfC b2460 JW2444 ypfC eutQ 25,418 ethanolamine catabolic process [GO:0046336] ethanolamine catabolic process [GO:0046336] GO:0046336 SUBCELLULAR LOCATION: Bacterial microcompartment {ECO:0000250|UniProtKB:Q9ZFV5}. Note=May be found on the cytoplasmic face of the BMC. {ECO:0000250|UniProtKB:Q9ZFV5}. +P77733 FOCB_ECOLI Probable formate transporter 2 (Formate channel 2) focB b2492 JW2477 focB 30,565 formate transport [GO:0015724]; mixed acid fermentation [GO:0019664] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; formate transmembrane transporter activity [GO:0015499]; formate transport [GO:0015724]; mixed acid fermentation [GO:0019664] formate transmembrane transporter activity [GO:0015499] GO:0005886; GO:0005887; GO:0015499; GO:0015724; GO:0019664 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P33235 FLGK_ECOLI Flagellar hook-associated protein 1 (HAP1) flgK flaS flaW b1082 JW1069 flaS flaW flgK 57,930 bacterial-type flagellum assembly [GO:0044780] bacterial-type flagellum hook [GO:0009424]; extracellular region [GO:0005576] bacterial-type flagellum hook [GO:0009424]; extracellular region [GO:0005576]; structural molecule activity [GO:0005198]; bacterial-type flagellum assembly [GO:0044780] structural molecule activity [GO:0005198] GO:0005198; GO:0005576; GO:0009424; GO:0044780 SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Bacterial flagellum {ECO:0000250}. +P10121 FTSY_ECOLI Signal recognition particle receptor FtsY (SRP receptor) ftsY b3464 JW3429 ftsY 54,513 protein targeting [GO:0006605]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] cytosol [GO:0005829]; extrinsic component of plasma membrane [GO:0019897]; intrinsic component of plasma membrane [GO:0031226]; membrane [GO:0016020]; plasma membrane [GO:0005886] cytosol [GO:0005829]; extrinsic component of plasma membrane [GO:0019897]; intrinsic component of plasma membrane [GO:0031226]; membrane [GO:0016020]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; signal recognition particle binding [GO:0005047]; protein targeting [GO:0006605]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] GTPase activity [GO:0003924]; GTP binding [GO:0005525]; signal recognition particle binding [GO:0005047] GO:0003924; GO:0005047; GO:0005525; GO:0005829; GO:0005886; GO:0006605; GO:0006614; GO:0016020; GO:0019897; GO:0031226 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:11353766, ECO:0000269|PubMed:17726013, ECO:0000269|PubMed:18281057, ECO:0000269|PubMed:19414018, ECO:0000269|PubMed:21543314, ECO:0000269|PubMed:8194520, ECO:0000269|PubMed:9177162}; Peripheral membrane protein {ECO:0000269|PubMed:11353766, ECO:0000269|PubMed:17726013, ECO:0000269|PubMed:18281057, ECO:0000269|PubMed:19414018, ECO:0000269|PubMed:21543314, ECO:0000269|PubMed:8194520, ECO:0000269|PubMed:9177162}; Cytoplasmic side {ECO:0000269|PubMed:11353766, ECO:0000269|PubMed:17726013, ECO:0000269|PubMed:18281057, ECO:0000269|PubMed:19414018, ECO:0000269|PubMed:21543314, ECO:0000269|PubMed:8194520, ECO:0000269|PubMed:9177162}. Cytoplasm {ECO:0000269|PubMed:18281057, ECO:0000269|PubMed:8194520}. Note=Distributed between the membrane and the cytoplasm (PubMed:18281057, PubMed:8194520). Binding to the membrane probably occurs initially through phospholipid binding, which allows a strong membrane contact, followed by interaction with a membrane protein (PubMed:11353766). Targeting of FtsY to the membrane is essential for proper function (PubMed:9177162). The stability of this membrane contact may be regulated by cleavage of helix 1 (PubMed:19414018). {ECO:0000269|PubMed:11353766, ECO:0000269|PubMed:18281057, ECO:0000269|PubMed:19414018, ECO:0000269|PubMed:8194520, ECO:0000269|PubMed:9177162}. +P0A9C9 GLPX_ECOLI Fructose-1,6-bisphosphatase 1 class 2 (FBPase 1 class 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 class 2) glpX b3925 JW3896 glpX 35,852 fructose 1,6-bisphosphate metabolic process [GO:0030388]; gluconeogenesis [GO:0006094]; glycerol metabolic process [GO:0006071] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; manganese ion binding [GO:0030145]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; gluconeogenesis [GO:0006094]; glycerol metabolic process [GO:0006071] fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; manganese ion binding [GO:0030145] GO:0005737; GO:0006071; GO:0006094; GO:0030145; GO:0030388; GO:0042132 SUBCELLULAR LOCATION: Cytoplasm. +P10346 GLNQ_ECOLI Glutamine transport ATP-binding protein GlnQ glnQ b0809 JW0794 glnQ 26,731 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ABC-type amino acid transporter activity [GO:0015424]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626] ABC-type amino acid transporter activity [GO:0015424]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0015424; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000269|PubMed:16079137}. +P0A825 GLYA_ECOLI Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1) glyA b2551 JW2535 glyA 45,317 folic acid metabolic process [GO:0046655]; glycine biosynthetic process from serine [GO:0019264]; glycine catabolic process [GO:0006546]; L-serine biosynthetic process [GO:0006564]; L-serine catabolic process [GO:0006565]; one-carbon metabolic process [GO:0006730]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; cobalt ion binding [GO:0050897]; glycine hydroxymethyltransferase activity [GO:0004372]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; serine binding [GO:0070905]; zinc ion binding [GO:0008270]; folic acid metabolic process [GO:0046655]; glycine biosynthetic process from serine [GO:0019264]; glycine catabolic process [GO:0006546]; L-serine biosynthetic process [GO:0006564]; L-serine catabolic process [GO:0006565]; one-carbon metabolic process [GO:0006730]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653] cobalt ion binding [GO:0050897]; glycine hydroxymethyltransferase activity [GO:0004372]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; serine binding [GO:0070905]; zinc ion binding [GO:0008270] GO:0004372; GO:0005737; GO:0005829; GO:0006546; GO:0006564; GO:0006565; GO:0006730; GO:0008270; GO:0016020; GO:0019264; GO:0030170; GO:0035999; GO:0042802; GO:0046653; GO:0046655; GO:0050897; GO:0070905 SUBCELLULAR LOCATION: Cytoplasm. +P0CF43 INSC4_ECOLI Transposase InsC for insertion element IS2H insC4 b2861 JW2829 insC4 13,452 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P37769 KDUD_ECOLI 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (EC 1.1.1.127) (2-deoxy-D-gluconate 3-dehydrogenase) (2-keto-3-deoxygluconate 5-dehydrogenase) (2-keto-3-deoxygluconate oxidoreductase) (KDG oxidoreductase) (20-ketosteroid reductase) (EC 1.1.1.-) kduD ygeC yqeD b2842 JW2810 ygeC yqeD kduD 27,070 D-galacturonate catabolic process [GO:0019698]; D-glucuronate catabolic process [GO:0042840] 11-deoxycorticosterone reductase activity [GO:0102635]; 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity [GO:0047001]; 2-deoxy-D-gluconate 3-dehydrogenase activity [GO:0008678]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0033764]; D-galacturonate catabolic process [GO:0019698]; D-glucuronate catabolic process [GO:0042840] 11-deoxycorticosterone reductase activity [GO:0102635]; 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity [GO:0047001]; 2-deoxy-D-gluconate 3-dehydrogenase activity [GO:0008678]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0033764] GO:0008678; GO:0016616; GO:0019698; GO:0033764; GO:0042840; GO:0047001; GO:0051287; GO:0102635 +P39399 LGOR_ECOLI Probable HTH-type transcriptional regulator LgoR lgoR yjjM b4357 JW5792 yjjM lgoR 35,397 galactonate catabolic process [GO:0019584]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; galactonate catabolic process [GO:0019584]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006355; GO:0019584 +P37005 LAST_ECOLI Uncharacterized tRNA/rRNA methyltransferase LasT (EC 2.1.1.-) lasT yjtD b4403 JW4366 yjtD lasT 25,259 tRNA nucleoside ribose methylation [GO:0002128] cytosol [GO:0005829] cytosol [GO:0005829]; RNA binding [GO:0003723]; tRNA (cytosine-2'-O-)-methyltransferase activity [GO:0052666]; tRNA (uracil-2'-O-)-methyltransferase activity [GO:0052665]; tRNA nucleoside ribose methylation [GO:0002128] RNA binding [GO:0003723]; tRNA (cytosine-2'-O-)-methyltransferase activity [GO:0052666]; tRNA (uracil-2'-O-)-methyltransferase activity [GO:0052665] GO:0002128; GO:0003723; GO:0005829; GO:0052665; GO:0052666 +P0ADF3 LPRH_ECOLI rho operon leader peptide (RhoL) rhoL b3782 JW3755 rhoL 3,750 transcriptional attenuation [GO:0031555] transcriptional attenuation [GO:0031555] GO:0031555 +P25894 LOIP_ECOLI Metalloprotease LoiP (EC 3.4.24.-) loiP yggG b2936 JW2903 yggG loiP 26,842 cellular hypotonic response [GO:0071476]; cellular response to heat [GO:0034605]; cellular response to UV [GO:0034644] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; cellular hypotonic response [GO:0071476]; cellular response to heat [GO:0034605]; cellular response to UV [GO:0034644] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] GO:0004222; GO:0008237; GO:0009279; GO:0034605; GO:0034644; GO:0046872; GO:0071476 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:17909889, ECO:0000269|PubMed:22491786}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000269|PubMed:17909889, ECO:0000269|PubMed:22491786}. Note=Proper membrane localization can depend on BepA. +P24174 MANC_ECOLI Mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) (GDP-mannose pyrophosphorylase) (GMP) (GMPP) manC cpsB rfbM b2049 JW2034 cpsB rfbM manC 53,016 colanic acid biosynthetic process [GO:0009242]; GDP-mannose biosynthetic process [GO:0009298]; hyperosmotic response [GO:0006972]; lipopolysaccharide biosynthetic process [GO:0009103] GTP binding [GO:0005525]; mannose-1-phosphate guanylyltransferase activity [GO:0004475]; colanic acid biosynthetic process [GO:0009242]; GDP-mannose biosynthetic process [GO:0009298]; hyperosmotic response [GO:0006972]; lipopolysaccharide biosynthetic process [GO:0009103] GTP binding [GO:0005525]; mannose-1-phosphate guanylyltransferase activity [GO:0004475] GO:0004475; GO:0005525; GO:0006972; GO:0009103; GO:0009242; GO:0009298 +P75826 LYSO_ECOLI Lysine exporter LysO (Lys outward permease) lysO ybjE b0874 JW0858 ybjE lysO 32,340 L-lysine transmembrane transport [GO:1903401] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; L-lysine efflux transmembrane transporter activity [GO:0015661]; L-lysine transmembrane transport [GO:1903401] L-lysine efflux transmembrane transporter activity [GO:0015661] GO:0005886; GO:0005887; GO:0015661; GO:1903401 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P28635 METQ_ECOLI D-methionine-binding lipoprotein MetQ metQ yaeC b0197 JW0193 yaeC metQ 29,432 D-methionine transport [GO:0048473] anchored component of plasma membrane [GO:0046658]; ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; outer membrane-bounded periplasmic space [GO:0030288] anchored component of plasma membrane [GO:0046658]; ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; outer membrane-bounded periplasmic space [GO:0030288]; D-methionine transport [GO:0048473] GO:0030288; GO:0046658; GO:0048473; GO:0055052 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P0A7C6 PEPE_ECOLI Peptidase E (EC 3.4.13.21) (Alpha-aspartyl dipeptidase) (Asp-specific dipeptidase) (Dipeptidase E) pepE b4021 JW3981 pepE 24,570 cytoplasm [GO:0005737] cytoplasm [GO:0005737]; dipeptidase activity [GO:0016805]; peptidase activity [GO:0008233]; serine-type peptidase activity [GO:0008236] dipeptidase activity [GO:0016805]; peptidase activity [GO:0008233]; serine-type peptidase activity [GO:0008236] GO:0005737; GO:0008233; GO:0008236; GO:0016805 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00510}. +P69874 POTA_ECOLI Spermidine/putrescine import ATP-binding protein PotA (EC 7.6.2.11) potA b1126 JW1112 potA 43,028 putrescine transport [GO:0015847]; spermidine transmembrane transport [GO:1903711] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; ABC-type polyamine transporter activity [GO:0015417]; ABC-type putrescine transporter activity [GO:0015594]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; nucleotide binding [GO:0000166]; putrescine transport [GO:0015847]; spermidine transmembrane transport [GO:1903711] ABC-type polyamine transporter activity [GO:0015417]; ABC-type putrescine transporter activity [GO:0015594]; ATPase activity [GO:0016887]; ATP binding [GO:0005524]; nucleotide binding [GO:0000166] GO:0000166; GO:0005524; GO:0005886; GO:0015417; GO:0015594; GO:0015847; GO:0016887; GO:0043190; GO:1903711 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01726, ECO:0000269|PubMed:1939142, ECO:0000269|PubMed:7592703}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01726, ECO:0000269|PubMed:1939142, ECO:0000269|PubMed:7592703}. +P31134 POTG_ECOLI Putrescine transport ATP-binding protein PotG (EC 7.6.2.16) potG b0855 JW5818 potG 41,931 putrescine transport [GO:0015847] ATP-binding cassette (ABC) transporter complex [GO:0043190] ATP-binding cassette (ABC) transporter complex [GO:0043190]; ABC-type putrescine transporter activity [GO:0015594]; ATP binding [GO:0005524]; putrescine transport [GO:0015847] ABC-type putrescine transporter activity [GO:0015594]; ATP binding [GO:0005524] GO:0005524; GO:0015594; GO:0015847; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P0AAH8 SAPF_ECOLI Putrescine export system ATP-binding protein SapF sapF b1290 JW1283 sapF 30,571 putrescine transport [GO:0015847] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; putrescine transmembrane transporter activity [GO:0015489]; putrescine transport [GO:0015847] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; putrescine transmembrane transporter activity [GO:0015489] GO:0005524; GO:0005886; GO:0015489; GO:0015847; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P51025 SFGH1_ECOLI S-formylglutathione hydrolase FrmB (FGH) (EC 3.1.2.12) frmB yaiM b0355 JW0346 yaiM frmB 31,424 formaldehyde catabolic process [GO:0046294]; formaldehyde metabolic process [GO:0046292] cytosol [GO:0005829] cytosol [GO:0005829]; carboxylic ester hydrolase activity [GO:0052689]; S-formylglutathione hydrolase activity [GO:0018738]; formaldehyde catabolic process [GO:0046294]; formaldehyde metabolic process [GO:0046292] carboxylic ester hydrolase activity [GO:0052689]; S-formylglutathione hydrolase activity [GO:0018738] GO:0005829; GO:0018738; GO:0046292; GO:0046294; GO:0052689 +P0AGC3 SLT_ECOLI Soluble lytic murein transglycosylase (EC 4.2.2.n1) (Exomuramidase) (Peptidoglycan lytic exotransglycosylase) (Slt70) slt sltY b4392 JW4355 sltY slt 73,353 cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; peptidoglycan-based cell wall [GO:0009274] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; peptidoglycan-based cell wall [GO:0009274]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; lyase activity [GO:0016829]; lytic endotransglycosylase activity [GO:0008932]; lytic transglycosylase activity [GO:0008933]; cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253] hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; lyase activity [GO:0016829]; lytic endotransglycosylase activity [GO:0008932]; lytic transglycosylase activity [GO:0008933] GO:0004553; GO:0008932; GO:0008933; GO:0009253; GO:0009274; GO:0016020; GO:0016829; GO:0030288; GO:0071555 SUBCELLULAR LOCATION: Periplasm. Note=Tightly associated with the murein sacculus. +P37194 SLP_ECOLI Outer membrane protein Slp slp b3506 JW3474 slp 20,964 cell outer membrane [GO:0009279]; outer membrane [GO:0019867] cell outer membrane [GO:0009279]; outer membrane [GO:0019867]; identical protein binding [GO:0042802] identical protein binding [GO:0042802] GO:0009279; GO:0019867; GO:0042802 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:16079137}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000269|PubMed:16079137}. +P77444 SUFS_ECOLI Cysteine desulfurase (EC 2.8.1.7) (Selenocysteine beta-lyase) (SCL) (Selenocysteine lyase) (EC 4.4.1.16) (Selenocysteine reductase) sufS csdB ynhB b1680 JW1670 csdB ynhB sufS 44,434 cysteine metabolic process [GO:0006534]; iron-sulfur cluster assembly [GO:0016226]; selenium compound metabolic process [GO:0001887]; sulfur compound metabolic process [GO:0006790]; sulfur incorporation into metallo-sulfur cluster [GO:0031162] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; cysteine desulfurase activity [GO:0031071]; pyridoxal phosphate binding [GO:0030170]; selenocysteine lyase activity [GO:0009000]; cysteine metabolic process [GO:0006534]; iron-sulfur cluster assembly [GO:0016226]; selenium compound metabolic process [GO:0001887]; sulfur compound metabolic process [GO:0006790]; sulfur incorporation into metallo-sulfur cluster [GO:0031162] cysteine desulfurase activity [GO:0031071]; pyridoxal phosphate binding [GO:0030170]; selenocysteine lyase activity [GO:0009000] GO:0001887; GO:0005737; GO:0006534; GO:0006790; GO:0009000; GO:0016226; GO:0030170; GO:0031071; GO:0031162 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P31549 THIP_ECOLI Thiamine transport system permease protein ThiP thiP yabK b0067 JW0066 yabK thiP 59,533 thiamine transmembrane transport [GO:0071934] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; thiamine transmembrane transporter activity [GO:0015234]; thiamine transmembrane transport [GO:0071934] thiamine transmembrane transporter activity [GO:0015234] GO:0005886; GO:0015234; GO:0016021; GO:0071934 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P31133 POTF_ECOLI Putrescine-binding periplasmic protein PotF potF b0854 JW0838 potF 40,840 putrescine transport [GO:0015847] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; putrescine binding [GO:0019810]; putrescine transport [GO:0015847] putrescine binding [GO:0019810] GO:0015847; GO:0019810; GO:0030288 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:8416922}. +P15640 PUR2_ECOLI Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase) purD b4005 JW3969 purD 45,940 'de novo' IMP biosynthetic process [GO:0006189]; cellular response to DNA damage stimulus [GO:0006974]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleotide biosynthetic process [GO:0006164] ATP binding [GO:0005524]; ATPase activity [GO:0016887]; metal ion binding [GO:0046872]; phosphoribosylamine-glycine ligase activity [GO:0004637]; 'de novo' IMP biosynthetic process [GO:0006189]; cellular response to DNA damage stimulus [GO:0006974]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleotide biosynthetic process [GO:0006164] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylamine-glycine ligase activity [GO:0004637] GO:0004637; GO:0005524; GO:0006164; GO:0006189; GO:0006974; GO:0009113; GO:0016887; GO:0046872 +P64534 RCNB_ECOLI Nickel/cobalt homeostasis protein RcnB rcnB yohN b2107 JW5346 yohN rcnB 12,466 cellular response to DNA damage stimulus [GO:0006974]; response to cobalt ion [GO:0032025]; response to nickel cation [GO:0010045]; response to peptide [GO:1901652] cytosol [GO:0005829]; outer membrane-bounded periplasmic space [GO:0030288] cytosol [GO:0005829]; outer membrane-bounded periplasmic space [GO:0030288]; copper ion binding [GO:0005507]; cellular response to DNA damage stimulus [GO:0006974]; response to cobalt ion [GO:0032025]; response to nickel cation [GO:0010045]; response to peptide [GO:1901652] copper ion binding [GO:0005507] GO:0005507; GO:0005829; GO:0006974; GO:0010045; GO:0030288; GO:0032025; GO:1901652 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:21665978}. +P75745 PXPC_ECOLI 5-oxoprolinase subunit C (5-OPase subunit C) (EC 3.5.2.9) (5-oxoprolinase (ATP-hydrolyzing) subunit C) pxpC ybgK b0712 JW0702 ybgK pxpC 34,386 cytosol [GO:0005829] cytosol [GO:0005829]; 5-oxoprolinase (ATP-hydrolyzing) activity [GO:0017168]; ATP binding [GO:0005524] 5-oxoprolinase (ATP-hydrolyzing) activity [GO:0017168]; ATP binding [GO:0005524] GO:0005524; GO:0005829; GO:0017168 +P39838 RCSD_ECOLI Phosphotransferase RcsD (EC 2.7.2.-) (Phosphotransfer intermediate RcsD) rcsD yojN yojP yojQ b2216 JW2204 yojN yojP yojQ rcsD 100,372 phosphorelay signal transduction system [GO:0000160]; protein autophosphorylation [GO:0046777] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; histidine phosphotransfer kinase activity [GO:0009927]; phosphorelay sensor kinase activity [GO:0000155]; phosphotransferase activity, carboxyl group as acceptor [GO:0016774]; phosphorelay signal transduction system [GO:0000160]; protein autophosphorylation [GO:0046777] ATP binding [GO:0005524]; histidine phosphotransfer kinase activity [GO:0009927]; phosphorelay sensor kinase activity [GO:0000155]; phosphotransferase activity, carboxyl group as acceptor [GO:0016774] GO:0000155; GO:0000160; GO:0005524; GO:0005886; GO:0005887; GO:0009927; GO:0016774; GO:0046777 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:11309126}; Multi-pass membrane protein {ECO:0000305|PubMed:11309126}. +P25740 RFAG_ECOLI Lipopolysaccharide core biosynthesis protein RfaG (EC 2.4.-.-) (Glucosyltransferase I) rfaG pcsA waaG b3631 JW3606 pcsA waaG rfaG 42,284 lipopolysaccharide core region biosynthetic process [GO:0009244] lipopolysaccharide glucosyltransferase I activity [GO:0008919]; transferase activity, transferring glycosyl groups [GO:0016757]; lipopolysaccharide core region biosynthetic process [GO:0009244] lipopolysaccharide glucosyltransferase I activity [GO:0008919]; transferase activity, transferring glycosyl groups [GO:0016757] GO:0008919; GO:0009244; GO:0016757 +P75817 RLMC_ECOLI 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC (EC 2.1.1.189) (23S rRNA(m5U747)-methyltransferase) rlmC rumB ybjF b0859 JW0843 rumB ybjF rlmC 41,956 rRNA base methylation [GO:0070475] 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; rRNA (uridine) methyltransferase activity [GO:0016436]; rRNA (uridine-C5-)-methyltransferase activity [GO:0070041]; rRNA base methylation [GO:0070475] 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; rRNA (uridine) methyltransferase activity [GO:0016436]; rRNA (uridine-C5-)-methyltransferase activity [GO:0070041] GO:0005506; GO:0016436; GO:0051539; GO:0070041; GO:0070475 +P37351 RPIB_ECOLI Ribose-5-phosphate isomerase B (EC 5.3.1.6) (Phosphoriboisomerase B) rpiB yjcA b4090 JW4051 yjcA rpiB 16,073 D-allose catabolic process [GO:0019316]; pentose-phosphate shunt, non-oxidative branch [GO:0009052] allose 6-phosphate isomerase activity [GO:0008786]; isomerase activity [GO:0016853]; ribose-5-phosphate isomerase activity [GO:0004751]; D-allose catabolic process [GO:0019316]; pentose-phosphate shunt, non-oxidative branch [GO:0009052] allose 6-phosphate isomerase activity [GO:0008786]; isomerase activity [GO:0016853]; ribose-5-phosphate isomerase activity [GO:0004751] GO:0004751; GO:0008786; GO:0009052; GO:0016853; GO:0019316 +P58042 RZOR_ECOLI Prophage outer membrane lipoprotein RzoR (o-spanin) (Outer membrane lipoprotein Rz1 from lambdoid prophage Rac) (Spanin from lambdoid prophage Rac, outer membrane subunit) rzoR b4528 JW5213 rzoR 6,761 cytolysis [GO:0019835]; viral release from host cell [GO:0019076] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; cytolysis [GO:0019835]; viral release from host cell [GO:0019076] GO:0009279; GO:0019076; GO:0019835 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}; Periplasmic side {ECO:0000250}. +P0ADX9 RSMD_ECOLI Ribosomal RNA small subunit methyltransferase D (EC 2.1.1.171) (16S rRNA m2G966 methyltransferase) (rRNA (guanine-N(2)-)-methyltransferase) rsmD yhhF b3465 JW3430 yhhF rsmD 21,678 rRNA base methylation [GO:0070475] 16S rRNA (guanine(966)-N(2))-methyltransferase activity [GO:0052913]; nucleic acid binding [GO:0003676]; rRNA base methylation [GO:0070475] 16S rRNA (guanine(966)-N(2))-methyltransferase activity [GO:0052913]; nucleic acid binding [GO:0003676] GO:0003676; GO:0052913; GO:0070475 +P76182 RSXD_ECOLI Ion-translocating oxidoreductase complex subunit D (EC 7.-.-.-) (Rsx electron transport complex subunit D) rsxD rnfD ydgO b1630 JW1622 rnfD ydgO rsxD 38,140 electron transport chain [GO:0022900]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; electron transport chain [GO:0022900]; transmembrane transport [GO:0055085] GO:0005886; GO:0016021; GO:0022900; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00462}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00462}. +Q47622 SAPA_ECOLI Probable ABC transporter periplasmic-binding protein SapA sapA b1294 JW1287 sapA 61,565 peptide transport [GO:0015833] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288]; peptide transmembrane transporter activity [GO:1904680]; peptide transport [GO:0015833] peptide transmembrane transporter activity [GO:1904680] GO:0015833; GO:0030288; GO:0043190; GO:1904680 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P62395 SECM_ECOLI Secretion monitor secM srrA yacA b0097 JW5007 srrA yacA secM 18,880 regulation of translation [GO:0006417] cytosol [GO:0005829]; periplasmic space [GO:0042597] cytosol [GO:0005829]; periplasmic space [GO:0042597]; translation regulator activity [GO:0045182]; regulation of translation [GO:0006417] translation regulator activity [GO:0045182] GO:0005829; GO:0006417; GO:0042597; GO:0045182 SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:1834634}. Periplasm {ECO:0000269|PubMed:1834634}. Note=The active form is cytosolic, while the periplasmic form is rapidly degraded, mainly by the tail-specific protease. +P0AG76 SBCD_ECOLI Nuclease SbcCD subunit D sbcD yajA b0398 JW0388 yajA sbcD 44,714 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication termination [GO:0006274] 3'-5' exonuclease activity [GO:0008408]; DNA binding [GO:0003677]; double-stranded DNA endodeoxyribonuclease activity [GO:1990238]; exodeoxyribonuclease activity [GO:0004529]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication termination [GO:0006274] 3'-5' exonuclease activity [GO:0008408]; DNA binding [GO:0003677]; double-stranded DNA endodeoxyribonuclease activity [GO:1990238]; exodeoxyribonuclease activity [GO:0004529]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014] GO:0000014; GO:0003677; GO:0004529; GO:0006260; GO:0006274; GO:0006281; GO:0006310; GO:0008408; GO:1990238 +P52045 SCPB_ECOLI Methylmalonyl-CoA decarboxylase (MMCD) (EC 4.1.1.-) (Transcarboxylase) scpB mmcD ygfG b2919 JW2886 mmcD ygfG scpB 29,173 fatty acid beta-oxidation [GO:0006635] cytosol [GO:0005829] cytosol [GO:0005829]; carboxy-lyase activity [GO:0016831]; enoyl-CoA hydratase activity [GO:0004300]; methylmalonyl-CoA decarboxylase activity [GO:0004492]; fatty acid beta-oxidation [GO:0006635] carboxy-lyase activity [GO:0016831]; enoyl-CoA hydratase activity [GO:0004300]; methylmalonyl-CoA decarboxylase activity [GO:0004492] GO:0004300; GO:0004492; GO:0005829; GO:0006635; GO:0016831 +P0AC41 SDHA_ECOLI Succinate dehydrogenase flavoprotein subunit (EC 1.3.5.1) sdhA b0723 JW0713 sdhA 64,422 aerobic respiration [GO:0009060]; anaerobic respiration [GO:0009061]; tricarboxylic acid cycle [GO:0006099] plasma membrane [GO:0005886]; plasma membrane succinate dehydrogenase complex [GO:0045282] plasma membrane [GO:0005886]; plasma membrane succinate dehydrogenase complex [GO:0045282]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; succinate dehydrogenase (ubiquinone) activity [GO:0008177]; succinate dehydrogenase activity [GO:0000104]; aerobic respiration [GO:0009060]; anaerobic respiration [GO:0009061]; tricarboxylic acid cycle [GO:0006099] electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; succinate dehydrogenase (ubiquinone) activity [GO:0008177]; succinate dehydrogenase activity [GO:0000104] GO:0000104; GO:0005886; GO:0006099; GO:0008177; GO:0009055; GO:0009060; GO:0009061; GO:0045282; GO:0050660 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16079137}; Cytoplasmic side {ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16079137}. +P17952 MURC_ECOLI UDP-N-acetylmuramate--L-alanine ligase (EC 6.3.2.8) (UDP-N-acetylmuramoyl-L-alanine synthetase) murC b0091 JW0089 murC 53,626 cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; UDP-N-acetylmuramate-L-alanine ligase activity [GO:0008763]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; UDP-N-acetylmuramate-L-alanine ligase activity [GO:0008763] GO:0000287; GO:0005524; GO:0005737; GO:0007049; GO:0008360; GO:0008763; GO:0009252; GO:0051301; GO:0071555 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P77455 PAAZ_ECOLI Bifunctional protein PaaZ [Includes: 2-oxepin-2(3H)-ylideneacetyl-CoA hydrolase (EC 3.3.2.12) (Oxepin-CoA hydrolase); 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (EC 1.2.1.91)] paaZ maoC ydbN b1387 JW1382 maoC ydbN paaZ 73,003 phenylacetate catabolic process [GO:0010124] enoyl-CoA hydratase activity [GO:0004300]; ether hydrolase activity [GO:0016803]; hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [GO:0016823]; oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [GO:0016726]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; phenylacetate catabolic process [GO:0010124] enoyl-CoA hydratase activity [GO:0004300]; ether hydrolase activity [GO:0016803]; hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [GO:0016823]; oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [GO:0016726]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620] GO:0004300; GO:0010124; GO:0016620; GO:0016726; GO:0016803; GO:0016823 +P30011 NADC_ECOLI Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) nadC b0109 JW0105 nadC 32,762 'de novo' NAD biosynthetic process from aspartate [GO:0034628]; NAD biosynthetic process [GO:0009435]; quinolinate catabolic process [GO:0034213] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; nicotinate-nucleotide diphosphorylase (carboxylating) activity [GO:0004514]; 'de novo' NAD biosynthetic process from aspartate [GO:0034628]; NAD biosynthetic process [GO:0009435]; quinolinate catabolic process [GO:0034213] nicotinate-nucleotide diphosphorylase (carboxylating) activity [GO:0004514] GO:0004514; GO:0005737; GO:0005829; GO:0009435; GO:0034213; GO:0034628 +P77245 MURR_ECOLI HTH-type transcriptional regulator MurR (MurPQ operon repressor) murR yfeT b2427 JW2420 yfeT murR 31,192 carbohydrate derivative metabolic process [GO:1901135]; carbohydrate metabolic process [GO:0005975]; N-acetylmuramic acid catabolic process [GO:0097173]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of carbohydrate catabolic process [GO:0043470]; regulation of transcription, DNA-templated [GO:0006355] carbohydrate derivative binding [GO:0097367]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; carbohydrate derivative metabolic process [GO:1901135]; carbohydrate metabolic process [GO:0005975]; N-acetylmuramic acid catabolic process [GO:0097173]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of carbohydrate catabolic process [GO:0043470]; regulation of transcription, DNA-templated [GO:0006355] carbohydrate derivative binding [GO:0097367]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0005975; GO:0006355; GO:0043470; GO:0045892; GO:0097173; GO:0097367; GO:1901135 +P31061 NOHA_ECOLI Prophage DNA-packing protein NohA (Prophage Qin DNA-packaging protein Nu1 homolog) nohA nohQ b1548 JW1541 nohQ nohA 21,404 +P32709 NRFD_ECOLI Protein NrfD nrfD yjcK b4073 JW4034 yjcK nrfD 35,042 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P42641 OBG_ECOLI GTPase ObgE/CgtA (EC 3.6.5.-) (GTP-binding protein Obg) obgE cgtA obg yhbZ b3183 JW3150 cgtA obg yhbZ obgE 43,286 chromosome segregation [GO:0007059]; dormancy process [GO:0022611]; negative regulation of ribosome biogenesis [GO:0090071]; ribosome assembly [GO:0042255] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanyl ribonucleotide binding [GO:0032561]; magnesium ion binding [GO:0000287]; ribosomal large subunit binding [GO:0043023]; rRNA binding [GO:0019843]; chromosome segregation [GO:0007059]; dormancy process [GO:0022611]; negative regulation of ribosome biogenesis [GO:0090071]; ribosome assembly [GO:0042255] DNA binding [GO:0003677]; GDP binding [GO:0019003]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; guanyl ribonucleotide binding [GO:0032561]; magnesium ion binding [GO:0000287]; ribosomal large subunit binding [GO:0043023]; rRNA binding [GO:0019843] GO:0000287; GO:0003677; GO:0003924; GO:0005525; GO:0005829; GO:0007059; GO:0019003; GO:0019843; GO:0022611; GO:0032561; GO:0042255; GO:0043023; GO:0090071 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01454, ECO:0000269|PubMed:15292126}. Note=The majority is associated with the 50S ribosomal subunit (PubMed:15292126), another group also sees association with 30S subunit (PubMed:15836769). {ECO:0000269|PubMed:15292126, ECO:0000269|PubMed:15836769}. +P0AFG0 NUSG_ECOLI Transcription termination/antitermination protein NusG nusG b3982 JW3945 nusG 20,532 DNA-templated transcription, elongation [GO:0006354]; DNA-templated transcription, termination [GO:0006353]; regulation of DNA-templated transcription, elongation [GO:0032784]; ribosome biogenesis [GO:0042254]; transcription antitermination [GO:0031564] cytosol [GO:0005829] cytosol [GO:0005829]; DNA-templated transcription, elongation [GO:0006354]; DNA-templated transcription, termination [GO:0006353]; regulation of DNA-templated transcription, elongation [GO:0032784]; ribosome biogenesis [GO:0042254]; transcription antitermination [GO:0031564] GO:0005829; GO:0006353; GO:0006354; GO:0031564; GO:0032784; GO:0042254 +P77334 PDER_ECOLI Cyclic di-GMP phosphodiesterase PdeR (EC 3.1.4.52) pdeR gmr yciR b1285 JW1278 gmr yciR pdeR 74,665 negative regulation of cyclase activity [GO:0031280]; posttranscriptional regulation of gene expression [GO:0010608] cyclic-guanylate-specific phosphodiesterase activity [GO:0071111]; GTP binding [GO:0005525]; negative regulation of cyclase activity [GO:0031280]; posttranscriptional regulation of gene expression [GO:0010608] cyclic-guanylate-specific phosphodiesterase activity [GO:0071111]; GTP binding [GO:0005525] GO:0005525; GO:0010608; GO:0031280; GO:0071111 +P0A905 SLYB_ECOLI Outer membrane lipoprotein SlyB slyB b1641 JW1633 slyB 15,602 cell outer membrane [GO:0009279] cell outer membrane [GO:0009279] GO:0009279 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P0AGD7 SRP54_ECOLI Signal recognition particle protein (Fifty-four homolog) (Ffh) (p48) ffh b2610 JW5414 ffh 49,787 protein targeting to membrane [GO:0006612]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]; signal recognition particle [GO:0048500] cytosol [GO:0005829]; ribonucleoprotein complex [GO:1990904]; signal recognition particle [GO:0048500]; 7S RNA binding [GO:0008312]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein targeting to membrane [GO:0006612]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] 7S RNA binding [GO:0008312]; GTPase activity [GO:0003924]; GTP binding [GO:0005525] GO:0003924; GO:0005525; GO:0005829; GO:0006612; GO:0006614; GO:0008312; GO:0048500; GO:1990904 SUBCELLULAR LOCATION: Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane. +P0A836 SUCC_ECOLI Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta) sucC b0728 JW0717 sucC 41,393 succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737]; cytosol [GO:0005829]; succinate-CoA ligase complex [GO:0042709]; succinate-CoA ligase complex (ADP-forming) [GO:0009361] cytoplasm [GO:0005737]; cytosol [GO:0005829]; succinate-CoA ligase complex [GO:0042709]; succinate-CoA ligase complex (ADP-forming) [GO:0009361]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]; succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; succinate-CoA ligase (ADP-forming) activity [GO:0004775] GO:0000287; GO:0004775; GO:0005524; GO:0005737; GO:0005829; GO:0006099; GO:0006104; GO:0009361; GO:0042709 +P75792 SUPH_ECOLI Sugar phosphatase YbiV (EC 3.1.3.23) ybiV supH b0822 JW0806 supH ybiV 30,413 cytosol [GO:0005829] cytosol [GO:0005829]; fructose-1-phosphatase activity [GO:0103026]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; sorbitol-6-phosphatase activity [GO:0050286]; sugar-phosphatase activity [GO:0050308] fructose-1-phosphatase activity [GO:0103026]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; sorbitol-6-phosphatase activity [GO:0050286]; sugar-phosphatase activity [GO:0050308] GO:0000287; GO:0005829; GO:0016791; GO:0050286; GO:0050308; GO:0103026 +P07395 SYFB_ECOLI Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) pheT b1713 JW1703 pheT 87,378 phenylalanyl-tRNA aminoacylation [GO:0006432] cytosol [GO:0005829]; membrane [GO:0016020]; phenylalanine-tRNA ligase complex [GO:0009328] cytosol [GO:0005829]; membrane [GO:0016020]; phenylalanine-tRNA ligase complex [GO:0009328]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; tRNA binding [GO:0000049]; phenylalanyl-tRNA aminoacylation [GO:0006432] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phenylalanine-tRNA ligase activity [GO:0004826]; tRNA binding [GO:0000049] GO:0000049; GO:0000287; GO:0004826; GO:0005524; GO:0005829; GO:0006432; GO:0009328; GO:0016020; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm. +P0A867 TALA_ECOLI Transaldolase A (EC 2.2.1.2) talA b2464 JW2448 talA 35,659 carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098] cytosol [GO:0005829] cytosol [GO:0005829]; sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity [GO:0004801]; carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt [GO:0006098] sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity [GO:0004801] GO:0004801; GO:0005829; GO:0005975; GO:0006098 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +Q47319 TAPT_ECOLI tRNA-uridine aminocarboxypropyltransferase (EC 2.5.1.25) (SAM-dependent 3-amino-3-carboxypropyl transferase) (tRNA U47 acp transferase A) (tRNA aminocarboxypropyltransferase) tapT tuaA yfiP b2583 JW5409 tuaA yfiP tapT 25,995 tRNA modification [GO:0006400] metal ion binding [GO:0046872]; tRNA-uridine aminocarboxypropyltransferase activity [GO:0016432]; tRNA modification [GO:0006400] metal ion binding [GO:0046872]; tRNA-uridine aminocarboxypropyltransferase activity [GO:0016432] GO:0006400; GO:0016432; GO:0046872 +Q46927 TCDA_ECOLI tRNA threonylcarbamoyladenosine dehydratase (EC 6.1.-.-) (t(6)A37 dehydratase) tcdA csdL ygdL b2812 JW2783 csdL ygdL tcdA 28,562 cyclic threonylcarbamoyladenosine biosynthetic process [GO:0061504] integral component of membrane [GO:0016021] integral component of membrane [GO:0016021]; ATP binding [GO:0005524]; potassium ion binding [GO:0030955]; sodium ion binding [GO:0031402]; tRNA threonylcarbamoyladenosine dehydratase [GO:0061503]; ubiquitin-like modifier activating enzyme activity [GO:0008641]; cyclic threonylcarbamoyladenosine biosynthetic process [GO:0061504] ATP binding [GO:0005524]; potassium ion binding [GO:0030955]; sodium ion binding [GO:0031402]; tRNA threonylcarbamoyladenosine dehydratase [GO:0061503]; ubiquitin-like modifier activating enzyme activity [GO:0008641] GO:0005524; GO:0008641; GO:0016021; GO:0030955; GO:0031402; GO:0061503; GO:0061504 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P0A7E1 PYRD_ECOLI Dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2) (DHOdehase) (DHOD) (DHODase) (Dihydroorotate oxidase) pyrD b0945 JW0928 pyrD 36,775 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; pyrimidine ribonucleotide biosynthetic process [GO:0009220] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; dihydroorotate dehydrogenase activity [GO:0004152]; FMN binding [GO:0010181]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; pyrimidine ribonucleotide biosynthetic process [GO:0009220] dihydroorotate dehydrogenase activity [GO:0004152]; FMN binding [GO:0010181] GO:0004152; GO:0005829; GO:0005886; GO:0006207; GO:0009220; GO:0010181; GO:0016020; GO:0044205 SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. +P61175 RL22_ECOLI 50S ribosomal protein L22 (Large ribosomal subunit protein uL22) rplV eryB b3315 JW3277 eryB rplV 12,226 response to antibiotic [GO:0046677]; ribosome assembly [GO:0042255]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934]; polysomal ribosome [GO:0042788] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934]; polysomal ribosome [GO:0042788]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; response to antibiotic [GO:0046677]; ribosome assembly [GO:0042255]; translation [GO:0006412] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GO:0003735; GO:0005829; GO:0006412; GO:0015934; GO:0019843; GO:0022625; GO:0042255; GO:0042788; GO:0046677 +P0AG55 RL6_ECOLI 50S ribosomal protein L6 (Large ribosomal subunit protein uL6) rplF b3305 JW3267 rplF 18,904 cytoplasmic translation [GO:0002181]; response to antibiotic [GO:0046677]; ribosomal large subunit assembly [GO:0000027] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; response to antibiotic [GO:0046677]; ribosomal large subunit assembly [GO:0000027] large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735] GO:0000027; GO:0002181; GO:0003735; GO:0005829; GO:0022625; GO:0046677; GO:0070180 +P33643 RLUD_ECOLI Ribosomal large subunit pseudouridine synthase D (EC 5.4.99.23) (23S rRNA pseudouridine(1911/1915/1917) synthase) (rRNA pseudouridylate synthase D) (rRNA-uridine isomerase D) rluD sfhB yfiI b2594 JW2576 sfhB yfiI rluD 37,122 enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; ribosomal large subunit assembly [GO:0000027] cytosol [GO:0005829] cytosol [GO:0005829]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; ribosomal large subunit assembly [GO:0000027] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159] GO:0000027; GO:0000455; GO:0003723; GO:0005829; GO:0009982; GO:0120159 +P39902 SPRT_ECOLI Protein SprT sprT yggI b2944 JW2911 yggI sprT 19,348 cytoplasm [GO:0005737] cytoplasm [GO:0005737]; zinc ion binding [GO:0008270] zinc ion binding [GO:0008270] GO:0005737; GO:0008270 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P32141 SQUT_ECOLI Sulfofructosephosphate aldolase (SFP aldolase) (EC 4.1.2.57) yihT b3881 JW3852 yihT 31,983 6-sulfoquinovose(1-) catabolic process [GO:1902777]; 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde [GO:0061720] 6-deoxy-6-sulfofructose-1-phosphate aldolase activity [GO:0061595]; 6-sulfoquinovose(1-) catabolic process [GO:1902777]; 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde [GO:0061720] 6-deoxy-6-sulfofructose-1-phosphate aldolase activity [GO:0061595] GO:0061595; GO:0061720; GO:1902777 +P75853 SSUA_ECOLI Putative aliphatic sulfonates-binding protein ssuA ycbO b0936 JW0919 ycbO ssuA 34,558 alkanesulfonate transport [GO:0042918]; sulfur compound metabolic process [GO:0006790] membrane [GO:0016020]; periplasmic space [GO:0042597] membrane [GO:0016020]; periplasmic space [GO:0042597]; alkanesulfonate transmembrane transporter activity [GO:0042959]; ATPase-coupled transmembrane transporter activity [GO:0042626]; transmembrane transporter activity [GO:0022857]; alkanesulfonate transport [GO:0042918]; sulfur compound metabolic process [GO:0006790] alkanesulfonate transmembrane transporter activity [GO:0042959]; ATPase-coupled transmembrane transporter activity [GO:0042626]; transmembrane transporter activity [GO:0022857] GO:0006790; GO:0016020; GO:0022857; GO:0042597; GO:0042626; GO:0042918; GO:0042959 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P0A7V0 RS2_ECOLI 30S ribosomal protein S2 (Small ribosomal subunit protein uS2) rpsB b0169 JW0164 rpsB 26,744 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627] cytosolic small ribosomal subunit [GO:0022627]; structural constituent of ribosome [GO:0003735]; zinc ion binding [GO:0008270]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] structural constituent of ribosome [GO:0003735]; zinc ion binding [GO:0008270] GO:0000028; GO:0003735; GO:0006412; GO:0008270; GO:0022627 +P33667 SELU_ECOLI tRNA 2-selenouridine synthase (EC 2.9.1.3) (Selenophosphate-dependent tRNA 2-selenouridine synthase) selU ybbB b0503 JW0491 ybbB selU 41,111 tRNA seleno-modification [GO:0070329]; tRNA wobble uridine modification [GO:0002098] transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765]; tRNA 2-selenouridine synthase activity [GO:0043828]; tRNA seleno-modification [GO:0070329]; tRNA wobble uridine modification [GO:0002098] transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765]; tRNA 2-selenouridine synthase activity [GO:0043828] GO:0002098; GO:0016765; GO:0043828; GO:0070329 +P39394 SYME_ECOLI Toxic protein SymE (Putative endoribonuclease SymE) (EC 3.1.-.-) symE dinL sosC yjiW b4347 JW4310 dinL sosC yjiW symE 12,203 cellular response to DNA damage stimulus [GO:0006974]; mRNA catabolic process [GO:0006402]; SOS response [GO:0009432] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; endoribonuclease activity [GO:0004521]; RNA binding [GO:0003723]; cellular response to DNA damage stimulus [GO:0006974]; mRNA catabolic process [GO:0006402]; SOS response [GO:0009432] DNA binding [GO:0003677]; endoribonuclease activity [GO:0004521]; RNA binding [GO:0003723] GO:0003677; GO:0003723; GO:0004521; GO:0005737; GO:0006402; GO:0006974; GO:0009432 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:17462020}. Note=Purifies with ribosomes. {ECO:0000269|PubMed:17462020}. +P60906 SYH_ECOLI Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS) hisS b2514 JW2498 hisS 47,029 histidyl-tRNA aminoacylation [GO:0006427] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; histidine-tRNA ligase activity [GO:0004821]; histidyl-tRNA aminoacylation [GO:0006427] ATP binding [GO:0005524]; histidine-tRNA ligase activity [GO:0004821] GO:0004821; GO:0005524; GO:0005829; GO:0006427 SUBCELLULAR LOCATION: Cytoplasm. +P60472 UPPS_ECOLI Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) (EC 2.5.1.31) (Ditrans,polycis-undecaprenylcistransferase) (Undecaprenyl diphosphate synthase) (UDS) (Undecaprenyl pyrophosphate synthase) (UPP synthase) ispU rth uppS yaeS b0174 JW0169 rth uppS yaeS ispU 28,444 cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; Gram-negative-bacterium-type cell wall biogenesis [GO:0043164]; peptidoglycan biosynthetic process [GO:0009252]; polyprenol biosynthetic process [GO:0016094]; regulation of cell shape [GO:0008360] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; di-trans,poly-cis-decaprenylcistransferase activity [GO:0008834]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; polyprenyltransferase activity [GO:0002094]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; Gram-negative-bacterium-type cell wall biogenesis [GO:0043164]; peptidoglycan biosynthetic process [GO:0009252]; polyprenol biosynthetic process [GO:0016094]; regulation of cell shape [GO:0008360] di-trans,poly-cis-decaprenylcistransferase activity [GO:0008834]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; polyprenyltransferase activity [GO:0002094] GO:0000287; GO:0002094; GO:0005737; GO:0005829; GO:0007049; GO:0008360; GO:0008834; GO:0009252; GO:0016094; GO:0030145; GO:0043164; GO:0051301; GO:0071555 +P0AGF6 TDCB_ECOLI L-threonine dehydratase catabolic TdcB (EC 4.3.1.19) (L-serine dehydratase) (EC 4.3.1.17) (Threonine deaminase) tdcB b3117 JW3088 tdcB 35,232 L-serine catabolic process [GO:0006565]; L-threonine catabolic process to propionate [GO:0070689]; protein homotetramerization [GO:0051289]; threonine catabolic process [GO:0006567] cytosol [GO:0005829] cytosol [GO:0005829]; amino acid binding [GO:0016597]; identical protein binding [GO:0042802]; L-serine ammonia-lyase activity [GO:0003941]; L-threonine ammonia-lyase activity [GO:0004794]; nucleotide binding [GO:0000166]; pyridoxal phosphate binding [GO:0030170]; threonine aldolase activity [GO:0004793]; L-serine catabolic process [GO:0006565]; L-threonine catabolic process to propionate [GO:0070689]; protein homotetramerization [GO:0051289]; threonine catabolic process [GO:0006567] amino acid binding [GO:0016597]; identical protein binding [GO:0042802]; L-serine ammonia-lyase activity [GO:0003941]; L-threonine ammonia-lyase activity [GO:0004794]; nucleotide binding [GO:0000166]; pyridoxal phosphate binding [GO:0030170]; threonine aldolase activity [GO:0004793] GO:0000166; GO:0003941; GO:0004793; GO:0004794; GO:0005829; GO:0006565; GO:0006567; GO:0016597; GO:0030170; GO:0042802; GO:0051289; GO:0070689 +P76562 TMCA_ECOLI tRNA(Met) cytidine acetyltransferase TmcA (EC 2.3.1.193) tmcA ypfI b2474 JW2459 ypfI tmcA 74,893 tRNA acetylation [GO:0051391]; tRNA wobble cytosine modification [GO:0002101] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; tRNA binding [GO:0000049]; tRNA N-acetyltransferase activity [GO:0051392]; tRNA acetylation [GO:0051391]; tRNA wobble cytosine modification [GO:0002101] ATP binding [GO:0005524]; tRNA binding [GO:0000049]; tRNA N-acetyltransferase activity [GO:0051392] GO:0000049; GO:0002101; GO:0005524; GO:0005737; GO:0051391; GO:0051392 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01886}. +P07023 TYRA_ECOLI T-protein [Includes: Chorismate mutase (CM) (EC 5.4.99.5); Prephenate dehydrogenase (PDH) (EC 1.3.1.12)] tyrA b2600 JW2581 tyrA 42,043 chorismate metabolic process [GO:0046417]; L-phenylalanine biosynthetic process [GO:0009094]; tyrosine biosynthetic process [GO:0006571] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; chorismate mutase activity [GO:0004106]; NAD+ binding [GO:0070403]; prephenate dehydrogenase (NAD+) activity [GO:0008977]; prephenate dehydrogenase (NADP+) activity [GO:0004665]; chorismate metabolic process [GO:0046417]; L-phenylalanine biosynthetic process [GO:0009094]; tyrosine biosynthetic process [GO:0006571] chorismate mutase activity [GO:0004106]; NAD+ binding [GO:0070403]; prephenate dehydrogenase (NAD+) activity [GO:0008977]; prephenate dehydrogenase (NADP+) activity [GO:0004665] GO:0004106; GO:0004665; GO:0005737; GO:0006571; GO:0008977; GO:0009094; GO:0046417; GO:0070403 SUBCELLULAR LOCATION: Cytoplasm. +P76027 OPPD_ECOLI Oligopeptide transport ATP-binding protein OppD oppD b1246 JW1238 oppD 37,188 protein transport [GO:0015031] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; protein transport [GO:0015031] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0015031; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. +P23836 PHOP_ECOLI Transcriptional regulatory protein PhoP phoP b1130 JW1116 phoP 25,535 positive regulation of transcription, DNA-templated [GO:0045893] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA-binding transcription activator activity [GO:0001216]; identical protein binding [GO:0042802]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; positive regulation of transcription, DNA-templated [GO:0045893] DNA-binding transcription activator activity [GO:0001216]; identical protein binding [GO:0042802]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000976; GO:0001216; GO:0005829; GO:0032993; GO:0042802; GO:0045893 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P32154 PTFLB_ECOLI Fructose-like PTS system EIIBC component [Includes: PTS system fructose-like EIIB component (EC 2.7.1.202) (Fructose-like phosphotransferase enzyme IIB component); PTS system fructose-like EIIC component (Fructose-like permease IIC component)] frvB yiiJ b3899 JW5562 yiiJ frvB 51,120 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; carbohydrate:proton symporter activity [GO:0005351]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity [GO:0022877]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] carbohydrate:proton symporter activity [GO:0005351]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity [GO:0022877]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005351; GO:0005886; GO:0009401; GO:0016021; GO:0016301; GO:0022877; GO:0090563 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00427, ECO:0000305|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00427}. +P69791 PTQA_ECOLI PTS system N,N'-diacetylchitobiose-specific EIIA component (EIIA-Chb) (EIII-Chb) (IIIcel) (N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA component) chbA celC b1736 JW1725 celC chbA 12,748 N,N'-diacetylchitobiose import [GO:1902815]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity [GO:0090566]; N,N'-diacetylchitobiose import [GO:1902815]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity [GO:0090566] GO:0005829; GO:0009401; GO:0032991; GO:0090566; GO:1902815 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A7Y0 RNC_ECOLI Ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III) rnc b2567 JW2551 rnc 25,550 mRNA processing [GO:0006397]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; tRNA processing [GO:0008033] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; magnesium ion binding [GO:0000287]; ribonuclease III activity [GO:0004525]; rRNA binding [GO:0019843]; mRNA processing [GO:0006397]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; tRNA processing [GO:0008033] ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; magnesium ion binding [GO:0000287]; ribonuclease III activity [GO:0004525]; rRNA binding [GO:0019843] GO:0000287; GO:0003725; GO:0004525; GO:0005524; GO:0005829; GO:0006364; GO:0006396; GO:0006397; GO:0008033; GO:0016075; GO:0019843; GO:0019899 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:4865702}. Note=Loosely associated with ribosomes. +P37014 RPNE_ECOLI Inactive recombination-promoting nuclease-like protein RpnE yfaD b2244 JW2238 yfaD 34,923 DNA recombination [GO:0006310] double-stranded DNA endodeoxyribonuclease activity [GO:1990238]; DNA recombination [GO:0006310] double-stranded DNA endodeoxyribonuclease activity [GO:1990238] GO:0006310; GO:1990238 +P32684 RLUF_ECOLI Dual-specificity RNA pseudouridine synthase RluF (EC 5.4.99.-) (EC 5.4.99.21) (23S rRNA pseudouridine(2604) synthase) (Ribosomal large subunit pseudouridine synthase F) (rRNA pseudouridylate synthase F) (rRNA-uridine isomerase F) (tRNA(Tyr) pseudouridine(35) synthase) rluF yjbC b4022 JW3982 yjbC rluF 32,477 enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; tRNA pseudouridine synthesis [GO:0031119] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159]; tRNA pseudouridine synthase activity [GO:0106029]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; tRNA pseudouridine synthesis [GO:0031119] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159]; tRNA pseudouridine synthase activity [GO:0106029] GO:0000455; GO:0003723; GO:0009982; GO:0031119; GO:0106029; GO:0120159 +P0AGB6 RPOE_ECOLI ECF RNA polymerase sigma-E factor (RNA polymerase sigma-E factor) (Sigma-24) rpoE sigE b2573 JW2557 sigE rpoE 21,696 DNA-templated transcription, initiation [GO:0006352]; regulation of transcription, DNA-templated [GO:0006355]; response to osmotic stress [GO:0006970]; response to temperature stimulus [GO:0009266] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; sigma factor activity [GO:0016987]; DNA-templated transcription, initiation [GO:0006352]; regulation of transcription, DNA-templated [GO:0006355]; response to osmotic stress [GO:0006970]; response to temperature stimulus [GO:0009266] DNA binding [GO:0003677]; sigma factor activity [GO:0016987] GO:0003677; GO:0005737; GO:0006352; GO:0006355; GO:0006970; GO:0009266; GO:0016987 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11777003, ECO:0000269|PubMed:9159522}. Note=Associates with the inner membrane via RseA (PubMed:9159522, PubMed:11777003). {ECO:0000269|PubMed:11777003}. +P0A9E2 SOXS_ECOLI Regulatory protein SoxS soxS b4062 JW4023 soxS 12,911 regulation of transcription, DNA-templated [GO:0006355] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; bacterial-type RNA polymerase holo enzyme binding [GO:0001108]; DNA-binding transcription factor activity [GO:0003700]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; bacterial-type RNA polymerase holo enzyme binding [GO:0001108]; DNA-binding transcription factor activity [GO:0003700] GO:0000986; GO:0001108; GO:0003700; GO:0005737; GO:0006355 SUBCELLULAR LOCATION: Cytoplasm. +P0A9K9 SLYD_ECOLI FKBP-type peptidyl-prolyl cis-trans isomerase SlyD (PPIase) (EC 5.2.1.8) (Histidine-rich protein) (Metallochaperone SlyD) (Rotamase) (Sensitivity to lysis protein D) (WHP) slyD b3349 JW3311 slyD 20,853 modulation by symbiont of host adenylate cyclase-mediated signal transduction [GO:0043963]; protein maturation [GO:0051604]; protein maturation by protein folding [GO:0022417]; protein peptidyl-prolyl isomerization [GO:0000413]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; response to heat [GO:0009408] cytosol [GO:0005829] cytosol [GO:0005829]; cobalt ion binding [GO:0050897]; copper ion binding [GO:0005507]; nickel cation binding [GO:0016151]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]; modulation by symbiont of host adenylate cyclase-mediated signal transduction [GO:0043963]; protein maturation [GO:0051604]; protein maturation by protein folding [GO:0022417]; protein peptidyl-prolyl isomerization [GO:0000413]; protein refolding [GO:0042026]; protein stabilization [GO:0050821]; response to heat [GO:0009408] cobalt ion binding [GO:0050897]; copper ion binding [GO:0005507]; nickel cation binding [GO:0016151]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270] GO:0000413; GO:0003755; GO:0005507; GO:0005829; GO:0008270; GO:0009408; GO:0016151; GO:0022417; GO:0042026; GO:0043963; GO:0050821; GO:0050897; GO:0051082; GO:0051604 SUBCELLULAR LOCATION: Cytoplasm. +P31548 THIQ_ECOLI Thiamine import ATP-binding protein ThiQ (EC 7.6.2.15) thiQ yabJ b0066 JW0065 yabJ thiQ 24,999 thiamine transmembrane transport [GO:0071934] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ABC-type thiamine transporter activity [GO:0048502]; ATP binding [GO:0005524]; thiamine transmembrane transporter activity [GO:0015234]; thiamine transmembrane transport [GO:0071934] ABC-type thiamine transporter activity [GO:0048502]; ATP binding [GO:0005524]; thiamine transmembrane transporter activity [GO:0015234] GO:0005524; GO:0005886; GO:0015234; GO:0016021; GO:0048502; GO:0071934 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01723}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01723}. +P39321 TAMB_ECOLI Translocation and assembly module subunit TamB (Autotransporter assembly factor TamB) tamB ytfN ytfO b4221 JW4180 ytfN ytfO tamB 136,780 protein localization to outer membrane [GO:0089705]; protein secretion [GO:0009306] integral component of plasma membrane [GO:0005887]; TAM protein secretion complex [GO:0097347] integral component of plasma membrane [GO:0005887]; TAM protein secretion complex [GO:0097347]; protein localization to outer membrane [GO:0089705]; protein secretion [GO:0009306] GO:0005887; GO:0009306; GO:0089705; GO:0097347 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:22466966}; Single-pass membrane protein {ECO:0000305|PubMed:22466966}. +P0ADA1 TESA_ECOLI Thioesterase 1/protease 1/lysophospholipase L1 (TAP) (Acyl-CoA thioesterase 1) (TESA) (EC 3.1.2.2) (Acyl-CoA thioesterase I) (Arylesterase) (EC 3.1.1.2) (Lysophospholipase L1) (EC 3.1.1.5) (Oleoyl-[acyl-carrier-protein] hydrolase) (EC 3.1.2.14) (Phospholipid degradation C) (Pldc) (Protease 1) (EC 3.4.21.-) (Protease I) (Thioesterase I/protease I) (TEP-I) tesA apeA pldC b0494 JW0483 apeA pldC tesA 23,622 lipid metabolic process [GO:0006629] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; acyl-CoA hydrolase activity [GO:0047617]; arylesterase activity [GO:0004064]; identical protein binding [GO:0042802]; lysophospholipase activity [GO:0004622]; myristoyl-[acyl-carrier-protein] hydrolase activity [GO:0016295]; myristoyl-CoA hydrolase activity [GO:0102991]; oleoyl-[acyl-carrier-protein] hydrolase activity [GO:0004320]; palmitoyl-[acyl-carrier-protein] hydrolase activity [GO:0016296]; palmitoyl-CoA hydrolase activity [GO:0016290]; peptidase activity [GO:0008233]; phosphatidyl phospholipase B activity [GO:0102545]; lipid metabolic process [GO:0006629] acyl-CoA hydrolase activity [GO:0047617]; arylesterase activity [GO:0004064]; identical protein binding [GO:0042802]; lysophospholipase activity [GO:0004622]; myristoyl-[acyl-carrier-protein] hydrolase activity [GO:0016295]; myristoyl-CoA hydrolase activity [GO:0102991]; oleoyl-[acyl-carrier-protein] hydrolase activity [GO:0004320]; palmitoyl-[acyl-carrier-protein] hydrolase activity [GO:0016296]; palmitoyl-CoA hydrolase activity [GO:0016290]; peptidase activity [GO:0008233]; phosphatidyl phospholipase B activity [GO:0102545] GO:0004064; GO:0004320; GO:0004622; GO:0006629; GO:0008233; GO:0016290; GO:0016295; GO:0016296; GO:0030288; GO:0042802; GO:0047617; GO:0102545; GO:0102991 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:8098033, ECO:0000269|PubMed:8432696}. +P24188 TRHO_ECOLI tRNA uridine(34) hydroxylase (EC 1.14.-.-) (ORF39.9) (tRNA hydroxylation protein O) trhO yceA b1055 JW1042 yceA trhO 39,781 tRNA modification [GO:0006400]; tRNA wobble uridine modification [GO:0002098] oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; tRNA modification [GO:0006400]; tRNA wobble uridine modification [GO:0002098] oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705] GO:0002098; GO:0006400; GO:0016491; GO:0016705 +P0A7I0 RF1_ECOLI Peptide chain release factor RF1 (RF-1) prfA sueB uar b1211 JW1202 sueB uar prfA 40,517 translational termination [GO:0006415] cytosol [GO:0005829] cytosol [GO:0005829]; ribosome binding [GO:0043022]; translation release factor activity, codon specific [GO:0016149]; translational termination [GO:0006415] ribosome binding [GO:0043022]; translation release factor activity, codon specific [GO:0016149] GO:0005829; GO:0006415; GO:0016149; GO:0043022 SUBCELLULAR LOCATION: Cytoplasm. +P30850 RNB_ECOLI Exoribonuclease 2 (EC 3.1.13.1) (Exoribonuclease II) (RNase II) (Ribonuclease II) rnb b1286 JW1279 rnb 72,491 mRNA catabolic process [GO:0006402] cytosol [GO:0005829] cytosol [GO:0005829]; 3'-5' exonuclease activity [GO:0008408]; exoribonuclease II activity [GO:0008859]; RNA binding [GO:0003723]; mRNA catabolic process [GO:0006402] 3'-5' exonuclease activity [GO:0008408]; exoribonuclease II activity [GO:0008859]; RNA binding [GO:0003723] GO:0003723; GO:0005829; GO:0006402; GO:0008408; GO:0008859 SUBCELLULAR LOCATION: Cytoplasm. +P0AA39 RLUC_ECOLI Ribosomal large subunit pseudouridine synthase C (EC 5.4.99.24) (23S rRNA pseudouridine(955/2504/2580) synthase) (rRNA pseudouridylate synthase C) (rRNA-uridine isomerase C) rluC yceC b1086 JW1072 yceC rluC 36,027 enzyme-directed rRNA pseudouridine synthesis [GO:0000455] cytosol [GO:0005829] cytosol [GO:0005829]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159] GO:0000455; GO:0003723; GO:0005829; GO:0009982; GO:0120159 +P09155 RND_ECOLI Ribonuclease D (RNase D) (EC 3.1.13.5) rnd b1804 JW1793 rnd 42,734 tRNA 3'-end processing [GO:0042780] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 3'-5'-exoribonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]; ribonuclease D activity [GO:0033890]; tRNA 3'-end processing [GO:0042780] 3'-5'-exoribonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]; ribonuclease D activity [GO:0033890] GO:0000166; GO:0000175; GO:0003676; GO:0005737; GO:0033890; GO:0042780 SUBCELLULAR LOCATION: Cytoplasm. +P0AFZ1 SSEB_ECOLI Protein SseB sseB b2522 JW5404 sseB 28,643 +P68398 TADA_ECOLI tRNA-specific adenosine deaminase (EC 3.5.4.33) tadA yfhC b2559 JW2543 yfhC tadA 18,718 adenosine to inosine editing [GO:0006382]; tRNA wobble adenosine to inosine editing [GO:0002100] tRNA-specific adenosine-34 deaminase activity [GO:0052717]; zinc ion binding [GO:0008270]; adenosine to inosine editing [GO:0006382]; tRNA wobble adenosine to inosine editing [GO:0002100] tRNA-specific adenosine-34 deaminase activity [GO:0052717]; zinc ion binding [GO:0008270] GO:0002100; GO:0006382; GO:0008270; GO:0052717 +P10905 UGPA_ECOLI sn-glycerol-3-phosphate transport system permease protein UgpA ugpA b3452 JW3417 ugpA 33,264 glycerol-3-phosphate transmembrane transport [GO:0015794]; glycerophosphodiester transmembrane transport [GO:0001407] ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; plasma membrane [GO:0005886]; glycerol-3-phosphate transmembrane transporter activity [GO:0015169]; glycerophosphodiester transmembrane transporter activity [GO:0001406]; glycerol-3-phosphate transmembrane transport [GO:0015794]; glycerophosphodiester transmembrane transport [GO:0001407] glycerol-3-phosphate transmembrane transporter activity [GO:0015169]; glycerophosphodiester transmembrane transporter activity [GO:0001406] GO:0001406; GO:0001407; GO:0005886; GO:0015169; GO:0015794; GO:0055052 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P12295 UNG_ECOLI Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) ung b2580 JW2564 ung 25,693 base-excision repair [GO:0006284]; base-excision repair, AP site formation via deaminated base removal [GO:0097510] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; uracil DNA N-glycosylase activity [GO:0004844]; base-excision repair [GO:0006284]; base-excision repair, AP site formation via deaminated base removal [GO:0097510] uracil DNA N-glycosylase activity [GO:0004844] GO:0004844; GO:0005737; GO:0006284; GO:0097510 SUBCELLULAR LOCATION: Cytoplasm. +P0A8G3 UXAC_ECOLI Uronate isomerase (EC 5.3.1.12) (Glucuronate isomerase) (Uronic isomerase) uxaC ygjX ygjY ygjZ b3092 JW3063 ygjX ygjY ygjZ uxaC 53,987 D-galacturonate catabolic process [GO:0019698]; D-glucuronate catabolic process [GO:0042840] glucuronate isomerase activity [GO:0008880]; D-galacturonate catabolic process [GO:0019698]; D-glucuronate catabolic process [GO:0042840] glucuronate isomerase activity [GO:0008880] GO:0008880; GO:0019698; GO:0042840 +P09373 PFLB_ECOLI Formate acetyltransferase 1 (EC 2.3.1.54) (Pyruvate formate-lyase 1) pflB pfl b0903 JW0886 pfl pflB 85,357 glucose metabolic process [GO:0006006]; threonine catabolic process [GO:0006567] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; formate C-acetyltransferase activity [GO:0008861]; glucose metabolic process [GO:0006006]; threonine catabolic process [GO:0006567] formate C-acetyltransferase activity [GO:0008861] GO:0005829; GO:0006006; GO:0006567; GO:0008861; GO:0016020 SUBCELLULAR LOCATION: Cytoplasm. +P14175 PROV_ECOLI Glycine betaine/proline betaine transport system ATP-binding protein ProV proV b2677 JW2652 proV 44,163 amino acid transport [GO:0006865]; glycine betaine transport [GO:0031460]; hyperosmotic response [GO:0006972] ATP-binding cassette (ABC) transporter complex [GO:0043190] ATP-binding cassette (ABC) transporter complex [GO:0043190]; amine transmembrane transporter activity [GO:0005275]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; osmosensor activity [GO:0005034]; amino acid transport [GO:0006865]; glycine betaine transport [GO:0031460]; hyperosmotic response [GO:0006972] amine transmembrane transporter activity [GO:0005275]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; osmosensor activity [GO:0005034] GO:0005034; GO:0005275; GO:0005524; GO:0006865; GO:0006972; GO:0031460; GO:0042626; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000269|PubMed:16079137}. +P0AFX9 RSEB_ECOLI Sigma-E factor regulatory protein RseB rseB b2571 JW2555 rseB 35,750 regulation of polysaccharide biosynthetic process [GO:0032885] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; antisigma factor binding [GO:0045152]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; regulation of polysaccharide biosynthetic process [GO:0032885] antisigma factor binding [GO:0045152]; identical protein binding [GO:0042802]; lipid binding [GO:0008289] GO:0008289; GO:0030288; GO:0032885; GO:0042802; GO:0045152 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:11777003, ECO:0000269|PubMed:9159522, ECO:0000269|PubMed:9159523}. Note=Partially associates with the inner membrane via RseA. +P0A6U5 RSMG_ECOLI Ribosomal RNA small subunit methyltransferase G (EC 2.1.1.170) (16S rRNA 7-methylguanosine methyltransferase) (16S rRNA m7G methyltransferase) (Glucose-inhibited division protein B) rsmG gidB b3740 JW3718 gidB rsmG 23,431 rRNA base methylation [GO:0070475] cytosol [GO:0005829] cytosol [GO:0005829]; rRNA (guanine-N7-)-methyltransferase activity [GO:0070043]; rRNA base methylation [GO:0070475] rRNA (guanine-N7-)-methyltransferase activity [GO:0070043] GO:0005829; GO:0070043; GO:0070475 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00074}. +P76158 RZPQ_ECOLI Uncharacterized protein RzpQ rzpQ ydfP b1553 JW1545 ydfP rzpQ 18,310 +P0AFQ5 RUTC_ECOLI Putative aminoacrylate peracid reductase RutC (EC 1.-.-.-) rutC ycdK b1010 JW0995 ycdK rutC 13,763 nitrogen utilization [GO:0019740]; organonitrogen compound catabolic process [GO:1901565]; pyrimidine nucleobase catabolic process [GO:0006208]; uracil catabolic process [GO:0006212] cytosol [GO:0005829] cytosol [GO:0005829]; deaminase activity [GO:0019239]; oxidoreductase activity [GO:0016491]; nitrogen utilization [GO:0019740]; organonitrogen compound catabolic process [GO:1901565]; pyrimidine nucleobase catabolic process [GO:0006208]; uracil catabolic process [GO:0006212] deaminase activity [GO:0019239]; oxidoreductase activity [GO:0016491] GO:0005829; GO:0006208; GO:0006212; GO:0016491; GO:0019239; GO:0019740; GO:1901565 +P60651 SPEB_ECOLI Agmatinase (EC 3.5.3.11) (Agmatine ureohydrolase) (AUH) speB b2937 JW2904 speB 33,557 putrescine biosynthetic process [GO:0009446]; putrescine biosynthetic process from arginine, using agmatinase [GO:0033389]; spermidine biosynthetic process [GO:0008295] cytosol [GO:0005829] cytosol [GO:0005829]; agmatinase activity [GO:0008783]; manganese ion binding [GO:0030145]; putrescine biosynthetic process [GO:0009446]; putrescine biosynthetic process from arginine, using agmatinase [GO:0033389]; spermidine biosynthetic process [GO:0008295] agmatinase activity [GO:0008783]; manganese ion binding [GO:0030145] GO:0005829; GO:0008295; GO:0008783; GO:0009446; GO:0030145; GO:0033389 +P33595 SGRR_ECOLI HTH-type transcriptional regulator SgrR sgrR yabN b0069 JW0068 yabN sgrR 63,975 negative regulation of transcription, DNA-templated [GO:0045892]; peptide transport [GO:0015833]; positive regulation of transcription, DNA-templated [GO:0045893] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding [GO:0000984]; peptide transmembrane transporter activity [GO:1904680]; negative regulation of transcription, DNA-templated [GO:0045892]; peptide transport [GO:0015833]; positive regulation of transcription, DNA-templated [GO:0045893] bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding [GO:0000984]; peptide transmembrane transporter activity [GO:1904680] GO:0000984; GO:0015833; GO:0030288; GO:0045892; GO:0045893; GO:1904680 +P76502 SIXA_ECOLI Phosphohistidine phosphatase SixA (EC 3.1.3.-) (RX6) sixA yfcW b2340 JW2337 yfcW sixA 17,208 cellular protein modification process [GO:0006464]; peptidyl-histidine dephosphorylation [GO:0035971]; regulation of phosphorelay signal transduction system [GO:0070297] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; protein histidine phosphatase activity [GO:0101006]; cellular protein modification process [GO:0006464]; peptidyl-histidine dephosphorylation [GO:0035971]; regulation of phosphorelay signal transduction system [GO:0070297] protein histidine phosphatase activity [GO:0101006] GO:0005737; GO:0006464; GO:0035971; GO:0070297; GO:0101006 +P00960 SYGA_ECOLI Glycine--tRNA ligase alpha subunit (EC 6.1.1.14) (Glycyl-tRNA synthetase alpha subunit) (GlyRS) glyQ glyS(A) b3560 JW3531 glyS(A) glyQ 34,774 glycyl-tRNA aminoacylation [GO:0006426] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; glycine-tRNA ligase activity [GO:0004820]; glycyl-tRNA aminoacylation [GO:0006426] ATP binding [GO:0005524]; glycine-tRNA ligase activity [GO:0004820] GO:0004820; GO:0005524; GO:0005829; GO:0006426 SUBCELLULAR LOCATION: Cytoplasm. +P0A8L1 SYS_ECOLI Serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) serS b0893 JW0876 serS 48,414 selenocysteine biosynthetic process [GO:0016260]; selenocysteinyl-tRNA(Sec) biosynthetic process [GO:0097056]; seryl-tRNA aminoacylation [GO:0006434] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; serine-tRNA ligase activity [GO:0004828]; selenocysteine biosynthetic process [GO:0016260]; selenocysteinyl-tRNA(Sec) biosynthetic process [GO:0097056]; seryl-tRNA aminoacylation [GO:0006434] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; serine-tRNA ligase activity [GO:0004828] GO:0000287; GO:0004828; GO:0005524; GO:0005829; GO:0006434; GO:0016260; GO:0042802; GO:0097056 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P0AF96 TABA_ECOLI Toxin-antitoxin biofilm protein TabA tabA yjgK b4252 JW5756 yjgK tabA 16,865 single-species biofilm formation [GO:0044010] cytosol [GO:0005829] cytosol [GO:0005829]; single-species biofilm formation [GO:0044010] GO:0005829; GO:0044010 +P0DP69 PHNE1_ECOLI Putative cryptic phosphonate transport system permease protein PhnE1 phnE1 b4104 JW4065 phnE1 22,797 organic phosphonate transport [GO:0015716]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; organic phosphonate transport [GO:0015716]; transmembrane transport [GO:0055085] GO:0005886; GO:0015716; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. +P0AFI7 PDXH_ECOLI Pyridoxine/pyridoxamine 5'-phosphate oxidase (EC 1.4.3.5) (PNP/PMP oxidase) (PNPOx) (Pyridoxal 5'-phosphate synthase) pdxH b1638 JW1630 pdxH 25,545 'de novo' pyridoxal 5'-phosphate biosynthetic process [GO:0036001]; pyridoxal phosphate biosynthetic process [GO:0042823]; pyridoxine biosynthetic process [GO:0008615] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; FMN binding [GO:0010181]; oxidoreductase activity [GO:0016491]; phosphate ion binding [GO:0042301]; protein homodimerization activity [GO:0042803]; pyridoxamine-phosphate oxidase activity [GO:0004733]; riboflavin binding [GO:1902444]; 'de novo' pyridoxal 5'-phosphate biosynthetic process [GO:0036001]; pyridoxal phosphate biosynthetic process [GO:0042823]; pyridoxine biosynthetic process [GO:0008615] FMN binding [GO:0010181]; oxidoreductase activity [GO:0016491]; phosphate ion binding [GO:0042301]; protein homodimerization activity [GO:0042803]; pyridoxamine-phosphate oxidase activity [GO:0004733]; riboflavin binding [GO:1902444] GO:0004733; GO:0005829; GO:0008615; GO:0010181; GO:0016491; GO:0032991; GO:0036001; GO:0042301; GO:0042803; GO:0042823; GO:1902444 +Q46806 PHYDA_ECOLI D-phenylhydantoinase (EC 3.5.2.-) (Hydantoin-utilizing enzyme HyuA) hyuA ygeZ b2873 JW2841 ygeZ hyuA 51,025 pyrimidine nucleobase catabolic process [GO:0006208] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pyrimidine nucleobase catabolic process [GO:0006208] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [GO:0016812]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] GO:0005737; GO:0006208; GO:0016812; GO:0042802; GO:0046872 +P0A9K7 PHOU_ECOLI Phosphate-specific transport system accessory protein PhoU (Pst system accessory protein PhoU) (Negative regulator of Pho regulon) phoU nmpA b3724 JW3702 nmpA phoU 27,417 cellular phosphate ion homeostasis [GO:0030643]; cellular response to antibiotic [GO:0071236]; cellular response to heat [GO:0034605]; cellular response to pH [GO:0071467]; cellular response to phosphate starvation [GO:0016036]; cellular response to starvation [GO:0009267]; negative regulation of gene expression [GO:0010629]; negative regulation of ion transmembrane transporter activity [GO:0032413]; negative regulation of phosphate metabolic process [GO:0045936]; negative regulation of phosphate transmembrane transport [GO:2000186]; pathogenesis [GO:0009405]; phosphate ion transport [GO:0006817]; regulation of cell growth [GO:0001558] cytoplasm [GO:0005737]; extrinsic component of plasma membrane [GO:0019897] cytoplasm [GO:0005737]; extrinsic component of plasma membrane [GO:0019897]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]; cellular phosphate ion homeostasis [GO:0030643]; cellular response to antibiotic [GO:0071236]; cellular response to heat [GO:0034605]; cellular response to pH [GO:0071467]; cellular response to phosphate starvation [GO:0016036]; cellular response to starvation [GO:0009267]; negative regulation of gene expression [GO:0010629]; negative regulation of ion transmembrane transporter activity [GO:0032413]; negative regulation of phosphate metabolic process [GO:0045936]; negative regulation of phosphate transmembrane transport [GO:2000186]; pathogenesis [GO:0009405]; phosphate ion transport [GO:0006817]; regulation of cell growth [GO:0001558] magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803] GO:0000287; GO:0001558; GO:0005737; GO:0006817; GO:0009267; GO:0009405; GO:0010629; GO:0016036; GO:0019897; GO:0030145; GO:0030643; GO:0032413; GO:0034605; GO:0042803; GO:0045936; GO:0071236; GO:0071467; GO:2000186 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:3536855}. +P28304 QOR1_ECOLI Quinone oxidoreductase 1 (EC 1.6.5.5) (NADPH:quinone reductase 1) (Zeta-crystallin homolog protein) qorA hcz qor qor1 b4051 JW4011 hcz qor qor1 qorA 35,172 cellular response to oxidative stress [GO:0034599] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; NADPH:quinone reductase activity [GO:0003960]; zinc ion binding [GO:0008270]; cellular response to oxidative stress [GO:0034599] NADPH:quinone reductase activity [GO:0003960]; zinc ion binding [GO:0008270] GO:0003960; GO:0005737; GO:0005829; GO:0008270; GO:0034599 +Q46920 QUEF_ECOLI NADPH-dependent 7-cyano-7-deazaguanine reductase (EC 1.7.1.13) (7-cyano-7-carbaguanine reductase) (NADPH-dependent nitrile oxidoreductase) (PreQ(0) reductase) queF yqcD b2794 JW2765 yqcD queF 32,588 queuosine biosynthetic process [GO:0008616] cytosol [GO:0005829] cytosol [GO:0005829]; oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [GO:0046857]; preQ1 synthase activity [GO:0033739]; queuosine biosynthetic process [GO:0008616] oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [GO:0046857]; preQ1 synthase activity [GO:0033739] GO:0005829; GO:0008616; GO:0033739; GO:0046857 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AEI4 RIMO_ECOLI Ribosomal protein S12 methylthiotransferase RimO (S12 MTTase) (S12 methylthiotransferase) (EC 2.8.4.4) (Ribosomal protein S12 (aspartate(89)-C(3))-methylthiotransferase) (Ribosome maturation factor RimO) rimO yliG b0835 JW0819 yliG rimO 49,582 peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid [GO:0018339]; tRNA modification [GO:0006400] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aspartic acid methylthiotransferase activity [GO:0035599]; metal ion binding [GO:0046872]; protein methylthiotransferase activity [GO:0103039]; peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid [GO:0018339]; tRNA modification [GO:0006400] 4 iron, 4 sulfur cluster binding [GO:0051539]; aspartic acid methylthiotransferase activity [GO:0035599]; metal ion binding [GO:0046872]; protein methylthiotransferase activity [GO:0103039] GO:0005829; GO:0006400; GO:0018339; GO:0035599; GO:0046872; GO:0051539; GO:0103039 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A7P5 RL34_ECOLI 50S ribosomal protein L34 (Large ribosomal subunit protein bL34) rpmH rimA ssaF b3703 JW3680 rimA ssaF rpmH 5,380 translation [GO:0006412] ribosome [GO:0005840] ribosome [GO:0005840]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412] structural constituent of ribosome [GO:0003735] GO:0003735; GO:0005840; GO:0006412 +P0AF90 RRAB_ECOLI Regulator of ribonuclease activity B rraB yjgD b4255 JW4212 yjgD rraB 15,603 mRNA catabolic process [GO:0006402]; regulation of catalytic activity [GO:0050790]; regulation of endoribonuclease activity [GO:0060699] cytosol [GO:0005829] cytosol [GO:0005829]; endoribonuclease inhibitor activity [GO:0060698]; enzyme binding [GO:0019899]; ribonuclease inhibitor activity [GO:0008428]; mRNA catabolic process [GO:0006402]; regulation of catalytic activity [GO:0050790]; regulation of endoribonuclease activity [GO:0060699] endoribonuclease inhibitor activity [GO:0060698]; enzyme binding [GO:0019899]; ribonuclease inhibitor activity [GO:0008428] GO:0005829; GO:0006402; GO:0008428; GO:0019899; GO:0050790; GO:0060698; GO:0060699 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01888}. +P0AFR0 RSSA_ECOLI NTE family protein RssA rssA ychK b1234 JW1222 ychK rssA 33,067 lipid catabolic process [GO:0016042]; phosphatidylcholine metabolic process [GO:0046470] lysophospholipase activity [GO:0004622]; lipid catabolic process [GO:0016042]; phosphatidylcholine metabolic process [GO:0046470] lysophospholipase activity [GO:0004622] GO:0004622; GO:0016042; GO:0046470 +C1P601 RZOQ_ECOLI Putative lipoprotein RzoQ rzoQ b4689 JW1545.1 rzoQ 9,463 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P14081 SELB_ECOLI Selenocysteine-specific elongation factor (SelB translation factor) selB fdhA b3590 JW3563 fdhA selB 68,867 selenocysteine incorporation [GO:0001514]; selenocysteine metabolic process [GO:0016259] cytosol [GO:0005829] cytosol [GO:0005829]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; selenocysteine insertion sequence binding [GO:0035368]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049]; selenocysteine incorporation [GO:0001514]; selenocysteine metabolic process [GO:0016259] GDP binding [GO:0019003]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; selenocysteine insertion sequence binding [GO:0035368]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049] GO:0000049; GO:0001514; GO:0003746; GO:0003924; GO:0005525; GO:0005829; GO:0016259; GO:0019003; GO:0035368 SUBCELLULAR LOCATION: Cytoplasm. +P52043 SCPC_ECOLI Propionyl-CoA:succinate CoA transferase (EC 2.8.3.-) scpC ygfH b2920 JW2887 ygfH scpC 53,824 acetate metabolic process [GO:0006083]; acetyl-CoA metabolic process [GO:0006084]; propionate metabolic process, methylcitrate cycle [GO:0019679] acetate CoA-transferase activity [GO:0008775]; acetyl-CoA hydrolase activity [GO:0003986]; propionyl-CoA:succinate CoA-transferase activity [GO:0043821]; acetate metabolic process [GO:0006083]; acetyl-CoA metabolic process [GO:0006084]; propionate metabolic process, methylcitrate cycle [GO:0019679] acetate CoA-transferase activity [GO:0008775]; acetyl-CoA hydrolase activity [GO:0003986]; propionyl-CoA:succinate CoA-transferase activity [GO:0043821] GO:0003986; GO:0006083; GO:0006084; GO:0008775; GO:0019679; GO:0043821 +P75715 SFMH_ECOLI Uncharacterized fimbrial-like protein SfmH sfmH b0533 JW5071 sfmH 35,696 cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; mannose binding [GO:0005537]; cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] mannose binding [GO:0005537] GO:0005537; GO:0007155; GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}. +P76194 SUFE_ECOLI Cysteine desulfuration protein SufE sufE ynhA b1679 JW1669 ynhA sufE 15,800 iron-sulfur cluster assembly [GO:0016226]; positive regulation of catalytic activity [GO:0043085]; response to oxidative stress [GO:0006979]; sulfur incorporation into metallo-sulfur cluster [GO:0031162] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; enzyme activator activity [GO:0008047]; sulfur carrier activity [GO:0097163]; iron-sulfur cluster assembly [GO:0016226]; positive regulation of catalytic activity [GO:0043085]; response to oxidative stress [GO:0006979]; sulfur incorporation into metallo-sulfur cluster [GO:0031162] enzyme activator activity [GO:0008047]; sulfur carrier activity [GO:0097163] GO:0005737; GO:0006979; GO:0008047; GO:0016226; GO:0031162; GO:0043085; GO:0097163 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P10906 UGPE_ECOLI sn-glycerol-3-phosphate transport system permease protein UgpE ugpE b3451 JW3416 ugpE 31,500 glycerol-3-phosphate transmembrane transport [GO:0015794]; glycerophosphodiester transmembrane transport [GO:0001407] ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; glycerol-3-phosphate transmembrane transporter activity [GO:0015169]; glycerol-3-phosphate transmembrane transport [GO:0015794]; glycerophosphodiester transmembrane transport [GO:0001407] glycerol-3-phosphate transmembrane transporter activity [GO:0015169] GO:0001407; GO:0005886; GO:0005887; GO:0015169; GO:0015794; GO:0055052 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:15919996}. +P0AD42 PGPC_ECOLI Phosphatidylglycerophosphatase C (EC 3.1.3.27) (Phosphatidylglycerolphosphate phosphatase C) (PGP phosphatase C) pgpC yfhB b2560 JW5408 yfhB pgpC 24,439 glycerophospholipid biosynthetic process [GO:0046474]; phosphatidylglycerol biosynthetic process [GO:0006655]; phospholipid catabolic process [GO:0009395] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; metal ion binding [GO:0046872]; phosphatidylglycerophosphatase activity [GO:0008962]; glycerophospholipid biosynthetic process [GO:0046474]; phosphatidylglycerol biosynthetic process [GO:0006655]; phospholipid catabolic process [GO:0009395] metal ion binding [GO:0046872]; phosphatidylglycerophosphatase activity [GO:0008962] GO:0005887; GO:0006655; GO:0008962; GO:0009395; GO:0046474; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:21148555}; Single-pass membrane protein {ECO:0000269|PubMed:21148555}. +P27247 PLSX_ECOLI Phosphate acyltransferase (EC 2.3.1.274) (Acyl-ACP phosphotransacylase) (Acyl-[acyl-carrier-protein]--phosphate acyltransferase) (Phosphate-acyl-ACP acyltransferase) plsX b1090 JW5156 plsX 38,214 fatty acid biosynthetic process [GO:0006633]; phospholipid biosynthetic process [GO:0008654] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; phosphate:acyl-[acyl carrier protein] acyltransferase activity [GO:0043811]; fatty acid biosynthetic process [GO:0006633]; phospholipid biosynthetic process [GO:0008654] phosphate:acyl-[acyl carrier protein] acyltransferase activity [GO:0043811] GO:0005737; GO:0006633; GO:0008654; GO:0043811 SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with the membrane possibly through PlsY. {ECO:0000305}. +P75746 PXPA_ECOLI 5-oxoprolinase subunit A (5-OPase subunit A) (EC 3.5.2.9) (5-oxoprolinase (ATP-hydrolyzing) subunit A) pxpA ybgL b0713 JW0703 ybgL pxpA 25,800 carbohydrate metabolic process [GO:0005975]; nitrogen compound metabolic process [GO:0006807] 5-oxoprolinase (ATP-hydrolyzing) activity [GO:0017168]; ATP binding [GO:0005524]; carbohydrate metabolic process [GO:0005975]; nitrogen compound metabolic process [GO:0006807] 5-oxoprolinase (ATP-hydrolyzing) activity [GO:0017168]; ATP binding [GO:0005524] GO:0005524; GO:0005975; GO:0006807; GO:0017168 +P0A8A8 RIMP_ECOLI Ribosome maturation factor RimP rimP yhbC b3170 JW5533 yhbC rimP 16,651 ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] cytosol [GO:0005829] cytosol [GO:0005829]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; translation [GO:0006412] GO:0000028; GO:0005829; GO:0006412; GO:0042274 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P27125 RHAT_ECOLI L-rhamnose-proton symporter (L-rhamnose-H(+) transport protein) rhaT b3907 JW3878 rhaT 37,320 rhamnose transmembrane transport [GO:0015762] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; rhamnose transmembrane transporter activity [GO:0015153]; symporter activity [GO:0015293]; rhamnose transmembrane transport [GO:0015762] rhamnose transmembrane transporter activity [GO:0015153]; symporter activity [GO:0015293] GO:0005886; GO:0015153; GO:0015293; GO:0015762; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AFW2 RMF_ECOLI Ribosome modulation factor (RMF) (Hibernation factor RMF) (Protein E) rmf b0953 JW0936 rmf 6,507 negative regulation of translation in response to stress [GO:0032055] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843]; negative regulation of translation in response to stress [GO:0032055] ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843] GO:0005737; GO:0019843; GO:0032055; GO:0043022; GO:0043024 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A7V3 RS3_ECOLI 30S ribosomal protein S3 (Small ribosomal subunit protein uS3) rpsC b3314 JW3276 rpsC 25,983 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; mRNA binding [GO:0003729]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] mRNA binding [GO:0003729]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GO:0000028; GO:0003729; GO:0003735; GO:0005829; GO:0006412; GO:0019843; GO:0022627 +P77551 RZPR_ECOLI Putative endopeptidase RzpR (EC 3.4.-.-) (Putative Rz endopeptidase from lambdoid prophage Rac) rzpR ydaX b1362 JW5212 ydaX rzpR 11,070 cytolysis [GO:0019835]; defense response to bacterium [GO:0042742]; viral release from host cell [GO:0019076] peptidase activity [GO:0008233]; cytolysis [GO:0019835]; defense response to bacterium [GO:0042742]; viral release from host cell [GO:0019076] peptidase activity [GO:0008233] GO:0008233; GO:0019076; GO:0019835; GO:0042742 +P0A812 RUVB_ECOLI Holliday junction ATP-dependent DNA helicase RuvB (EC 3.6.4.12) ruvB b1860 JW1849 ruvB 37,174 recombinational repair [GO:0000725]; response to UV [GO:0009411]; SOS response [GO:0009432] cytosol [GO:0005829]; Holliday junction resolvase complex [GO:0048476] cytosol [GO:0005829]; Holliday junction resolvase complex [GO:0048476]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; four-way junction helicase activity [GO:0009378]; recombinational repair [GO:0000725]; response to UV [GO:0009411]; SOS response [GO:0009432] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; four-way junction helicase activity [GO:0009378] GO:0000725; GO:0003677; GO:0003678; GO:0005524; GO:0005829; GO:0009378; GO:0009411; GO:0009432; GO:0048476 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21219465}. Note=In 15% of cell localizes to discrete nucleoid foci (probable DNA damage sites) upon treatment with mitomycin C (MMC) for 2 hours. +P0AA41 TRUC_ECOLI tRNA pseudouridine synthase C (EC 5.4.99.26) (tRNA pseudouridine(65) synthase) (tRNA pseudouridylate synthase C) (tRNA-uridine isomerase C) truC yqcB b2791 JW2762 yqcB truC 29,666 enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; RNA modification [GO:0009451]; tRNA metabolic process [GO:0006399]; tRNA processing [GO:0008033]; tRNA pseudouridine synthesis [GO:0031119] cytosol [GO:0005829] cytosol [GO:0005829]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine synthase activity [GO:0106029]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; RNA modification [GO:0009451]; tRNA metabolic process [GO:0006399]; tRNA processing [GO:0008033]; tRNA pseudouridine synthesis [GO:0031119] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine synthase activity [GO:0106029] GO:0000455; GO:0003723; GO:0005829; GO:0006399; GO:0008033; GO:0009451; GO:0009982; GO:0031119; GO:0106029 +P39160 UXUB_ECOLI D-mannonate oxidoreductase (EC 1.1.1.57) (Fructuronate reductase) uxuB b4323 JW4286 uxuB 53,580 D-glucuronate catabolic process [GO:0042840]; mannitol metabolic process [GO:0019594] fructuronate reductase activity [GO:0008866]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; D-glucuronate catabolic process [GO:0042840]; mannitol metabolic process [GO:0019594] fructuronate reductase activity [GO:0008866]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] GO:0008866; GO:0016616; GO:0019594; GO:0042840 +P26647 PLSC_ECOLI 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-AGP acyltransferase) (1-AGPAT) (EC 2.3.1.51) (EC 2.3.1.n4) (Lysophosphatidic acid acyltransferase) (LPAAT) (Phosphatidic acid synthase) (PA synthase) plsC parF b3018 JW2986 parF plsC 27,453 CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654] 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841] GO:0003841; GO:0005886; GO:0006654; GO:0016024 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:1557036}; Peripheral membrane protein {ECO:0000269|PubMed:1557036}. +P75966 RLUE_ECOLI Ribosomal large subunit pseudouridine synthase E (EC 5.4.99.20) (rRNA pseudouridylate synthase E) (rRNA-uridine isomerase E) rluE ymfC b1135 JW1121 ymfC rluE 24,880 enzyme-directed rRNA pseudouridine synthesis [GO:0000455] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159] GO:0000455; GO:0003723; GO:0009982; GO:0120159 +P0A7V8 RS4_ECOLI 30S ribosomal protein S4 (Small ribosomal subunit protein uS4) rpsD ramA b3296 JW3258 ramA rpsD 23,469 DNA-templated transcription, termination [GO:0006353]; maintenance of translational fidelity [GO:1990145]; negative regulation of translational initiation [GO:0045947]; positive regulation of translational fidelity [GO:0045903]; response to antibiotic [GO:0046677]; ribosomal small subunit assembly [GO:0000028]; transcription antitermination [GO:0031564] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935]; mRNA 5'-UTR binding [GO:0048027]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; translation repressor activity, mRNA regulatory element binding [GO:0000900]; DNA-templated transcription, termination [GO:0006353]; maintenance of translational fidelity [GO:1990145]; negative regulation of translational initiation [GO:0045947]; positive regulation of translational fidelity [GO:0045903]; response to antibiotic [GO:0046677]; ribosomal small subunit assembly [GO:0000028]; transcription antitermination [GO:0031564] mRNA 5'-UTR binding [GO:0048027]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; translation repressor activity, mRNA regulatory element binding [GO:0000900] GO:0000028; GO:0000900; GO:0003735; GO:0005829; GO:0006353; GO:0015935; GO:0019843; GO:0022627; GO:0031564; GO:0045903; GO:0045947; GO:0046677; GO:0048027; GO:1990145 +P10408 SECA_ECOLI Protein translocase subunit SecA (EC 7.4.2.8) secA azi pea prlD b0098 JW0096 azi pea prlD secA 102,023 chaperone-mediated protein folding [GO:0061077]; intracellular protein transmembrane transport [GO:0065002]; protein import [GO:0017038]; protein targeting [GO:0006605]; protein transport [GO:0015031]; protein transport by the Sec complex [GO:0043952] cell envelope Sec protein transport complex [GO:0031522]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cell envelope Sec protein transport complex [GO:0031522]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ABC-type protein transporter activity [GO:0015462]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; preprotein binding [GO:0070678]; zinc ion binding [GO:0008270]; chaperone-mediated protein folding [GO:0061077]; intracellular protein transmembrane transport [GO:0065002]; protein import [GO:0017038]; protein targeting [GO:0006605]; protein transport [GO:0015031]; protein transport by the Sec complex [GO:0043952] ABC-type protein transporter activity [GO:0015462]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; preprotein binding [GO:0070678]; zinc ion binding [GO:0008270] GO:0005524; GO:0005737; GO:0005829; GO:0005886; GO:0005887; GO:0006605; GO:0008270; GO:0015031; GO:0015462; GO:0017038; GO:0031522; GO:0042802; GO:0043952; GO:0061077; GO:0065002; GO:0070678 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01382}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01382}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_01382}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01382}. Note=Distribution is 50-50. {ECO:0000255|HAMAP-Rule:MF_01382}. +P80645 SSUD_ECOLI Alkanesulfonate monooxygenase (EC 1.14.14.5) (FMNH2-dependent aliphatic sulfonate monooxygenase) (Sulfate starvation-induced protein 6) (SSI6) ssuD ycbN b0935 JW0918 ycbN ssuD 41,736 alkanesulfonate catabolic process [GO:0046306]; protein homotetramerization [GO:0051289]; response to heat [GO:0009408] alkanesulfonate monooxygenase complex [GO:1990201] alkanesulfonate monooxygenase complex [GO:1990201]; alkanesulfonate monooxygenase activity [GO:0008726]; identical protein binding [GO:0042802]; alkanesulfonate catabolic process [GO:0046306]; protein homotetramerization [GO:0051289]; response to heat [GO:0009408] alkanesulfonate monooxygenase activity [GO:0008726]; identical protein binding [GO:0042802] GO:0008726; GO:0009408; GO:0042802; GO:0046306; GO:0051289; GO:1990201 +P21889 SYD_ECOLI Aspartate--tRNA ligase (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) aspS tls b1866 JW1855 tls aspS 65,913 aspartyl-tRNA aminoacylation [GO:0006422] cytosol [GO:0005829] cytosol [GO:0005829]; aspartate-tRNA ligase activity [GO:0004815]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676]; aspartyl-tRNA aminoacylation [GO:0006422] aspartate-tRNA ligase activity [GO:0004815]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676] GO:0003676; GO:0004815; GO:0005524; GO:0005829; GO:0006422 SUBCELLULAR LOCATION: Cytoplasm. +P0A884 TYSY_ECOLI Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) thyA b2827 JW2795 thyA 30,480 dTMP biosynthetic process [GO:0006231]; dTTP biosynthetic process [GO:0006235]; methylation [GO:0032259]; regulation of translation [GO:0006417]; response to radiation [GO:0009314] cytosol [GO:0005829] cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; RNA binding [GO:0003723]; thymidylate synthase activity [GO:0004799]; dTMP biosynthetic process [GO:0006231]; dTTP biosynthetic process [GO:0006235]; methylation [GO:0032259]; regulation of translation [GO:0006417]; response to radiation [GO:0009314] magnesium ion binding [GO:0000287]; RNA binding [GO:0003723]; thymidylate synthase activity [GO:0004799] GO:0000287; GO:0003723; GO:0004799; GO:0005829; GO:0006231; GO:0006235; GO:0006417; GO:0009314; GO:0032259 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00008}. +P0AFJ5 PHOB_ECOLI Phosphate regulon transcriptional regulatory protein PhoB phoB b0399 JW0389 phoB 26,433 phosphate ion transport [GO:0006817]; regulation of DNA-templated transcription, initiation [GO:2000142] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; bacterial-type RNA polymerase holo enzyme binding [GO:0001108]; DNA-binding transcription activator activity [GO:0001216]; identical protein binding [GO:0042802]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; phosphate ion transport [GO:0006817]; regulation of DNA-templated transcription, initiation [GO:2000142] bacterial-type RNA polymerase holo enzyme binding [GO:0001108]; DNA-binding transcription activator activity [GO:0001216]; identical protein binding [GO:0042802]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000976; GO:0001108; GO:0001216; GO:0005829; GO:0006817; GO:0032993; GO:0042802; GO:2000142 SUBCELLULAR LOCATION: Cytoplasm. +P18200 PGPA_ECOLI Phosphatidylglycerophosphatase A (EC 3.1.3.27) (Phosphatidylglycerolphosphate phosphatase A) (PGP phosphatase A) pgpA yajN b0418 JW0408 yajN pgpA 19,418 glycerophospholipid biosynthetic process [GO:0046474]; phosphatidylglycerol biosynthetic process [GO:0006655]; phospholipid catabolic process [GO:0009395]; phospholipid dephosphorylation [GO:0046839]; response to magnesium ion [GO:0032026] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; lipid phosphatase activity [GO:0042577]; metal ion binding [GO:0046872]; phosphatidylglycerophosphatase activity [GO:0008962]; glycerophospholipid biosynthetic process [GO:0046474]; phosphatidylglycerol biosynthetic process [GO:0006655]; phospholipid catabolic process [GO:0009395]; phospholipid dephosphorylation [GO:0046839]; response to magnesium ion [GO:0032026] lipid phosphatase activity [GO:0042577]; metal ion binding [GO:0046872]; phosphatidylglycerophosphatase activity [GO:0008962] GO:0005886; GO:0005887; GO:0006655; GO:0008962; GO:0009395; GO:0032026; GO:0042577; GO:0046474; GO:0046839; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:21148555}; Multi-pass membrane protein {ECO:0000269|PubMed:21148555}. +P32171 RHAB_ECOLI L-Rhamnulokinase (RhaB) (RhuK) (EC 2.7.1.5) (ATP:L-rhamnulose phosphotransferase) (L-rhamnulose 1-kinase) (Rhamnulose kinase) rhaB b3904 JW3875 rhaB 54,069 rhamnose catabolic process [GO:0019301] ATP binding [GO:0005524]; rhamnulokinase activity [GO:0008993]; rhamnose catabolic process [GO:0019301] ATP binding [GO:0005524]; rhamnulokinase activity [GO:0008993] GO:0005524; GO:0008993; GO:0019301 +P14176 PROW_ECOLI Glycine betaine/proline betaine transport system permease protein ProW proW b2678 JW2653 proW 37,620 amino acid transport [GO:0006865]; carnitine transmembrane transport [GO:1902603]; choline transport [GO:0015871]; glycine betaine transport [GO:0031460]; hyperosmotic response [GO:0006972] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; amine transmembrane transporter activity [GO:0005275]; carnitine transmembrane transporter activity [GO:0015226]; amino acid transport [GO:0006865]; carnitine transmembrane transport [GO:1902603]; choline transport [GO:0015871]; glycine betaine transport [GO:0031460]; hyperosmotic response [GO:0006972] amine transmembrane transporter activity [GO:0005275]; carnitine transmembrane transporter activity [GO:0015226] GO:0005275; GO:0005886; GO:0005887; GO:0006865; GO:0006972; GO:0015226; GO:0015871; GO:0031460; GO:0043190; GO:1902603 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P76440 PRET_ECOLI NAD-dependent dihydropyrimidine dehydrogenase subunit PreT (DPD) (EC 1.3.1.1) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) preT yeiT b2146 JW2133 yeiT preT 44,329 pyrimidine nucleobase catabolic process [GO:0006208] dihydrouracil dehydrogenase (NAD+) activity [GO:0004159]; iron-sulfur cluster binding [GO:0051536]; NADH dehydrogenase activity [GO:0003954]; oxidoreductase activity [GO:0016491]; pyrimidine nucleobase catabolic process [GO:0006208] dihydrouracil dehydrogenase (NAD+) activity [GO:0004159]; iron-sulfur cluster binding [GO:0051536]; NADH dehydrogenase activity [GO:0003954]; oxidoreductase activity [GO:0016491] GO:0003954; GO:0004159; GO:0006208; GO:0016491; GO:0051536 +P08179 PUR3_ECOLI Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART) purN b2500 JW2485 purN 23,238 'de novo' IMP biosynthetic process [GO:0006189]; cellular response to DNA damage stimulus [GO:0006974] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; phosphoribosylglycinamide formyltransferase activity [GO:0004644]; 'de novo' IMP biosynthetic process [GO:0006189]; cellular response to DNA damage stimulus [GO:0006974] phosphoribosylglycinamide formyltransferase activity [GO:0004644] GO:0004644; GO:0005737; GO:0005829; GO:0006189; GO:0006974 +P02925 RBSB_ECOLI Ribose import binding protein RbsB rbsB prlB rbsP b3751 JW3730 prlB rbsP rbsB 30,950 D-ribose transmembrane transport [GO:0015752]; positive chemotaxis [GO:0050918] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; monosaccharide binding [GO:0048029]; D-ribose transmembrane transport [GO:0015752]; positive chemotaxis [GO:0050918] monosaccharide binding [GO:0048029] GO:0015752; GO:0016020; GO:0030288; GO:0048029; GO:0050918 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:1583688}. +P0ACQ0 RBSR_ECOLI Ribose operon repressor rbsR b3753 JW3732 rbsR 36,612 positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0000986; GO:0001216; GO:0003700; GO:0006355; GO:0045893 +P0A7H6 RECR_ECOLI Recombination protein RecR recR b0472 JW0461 recR 21,963 DNA recombination [GO:0006310]; DNA synthesis involved in DNA repair [GO:0000731]; response to radiation [GO:0009314]; response to UV [GO:0009411] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; DNA recombination [GO:0006310]; DNA synthesis involved in DNA repair [GO:0000731]; response to radiation [GO:0009314]; response to UV [GO:0009411] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GO:0000731; GO:0003677; GO:0006310; GO:0009314; GO:0009411; GO:0046872 +P0A843 TATE_ECOLI Sec-independent protein translocase protein TatE tatE ybeC b0627 JW0622 ybeC tatE 7,024 protein transport by the Tat complex [GO:0043953] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; TAT protein transport complex [GO:0033281] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; TAT protein transport complex [GO:0033281]; protein transmembrane transporter activity [GO:0008320]; protein transport by the Tat complex [GO:0043953] protein transmembrane transporter activity [GO:0008320] GO:0005886; GO:0005887; GO:0008320; GO:0033281; GO:0043953 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00903}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00903}. +P0AGG4 THIO2_ECOLI Thioredoxin 2 (Trx-2) (EC 1.8.1.8) (Protein-disulfide reductase) trxC yfiG b2582 JW2566 yfiG trxC 15,555 cell redox homeostasis [GO:0045454]; glycerol ether metabolic process [GO:0006662] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein disulfide oxidoreductase activity [GO:0015035]; protein-disulfide reductase activity [GO:0047134]; zinc ion binding [GO:0008270]; cell redox homeostasis [GO:0045454]; glycerol ether metabolic process [GO:0006662] oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein disulfide oxidoreductase activity [GO:0015035]; protein-disulfide reductase activity [GO:0047134]; zinc ion binding [GO:0008270] GO:0005737; GO:0005829; GO:0006662; GO:0008270; GO:0015035; GO:0016671; GO:0045454; GO:0047134 SUBCELLULAR LOCATION: Cytoplasm. +P08390 USG_ECOLI USG-1 protein usg b2319 JW2316 usg 36,364 cellular amino acid biosynthetic process [GO:0008652] cytosol [GO:0005829] cytosol [GO:0005829]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; protein dimerization activity [GO:0046983]; cellular amino acid biosynthetic process [GO:0008652] NAD binding [GO:0051287]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; protein dimerization activity [GO:0046983] GO:0005829; GO:0008652; GO:0016620; GO:0046983; GO:0051287 +P75898 RUTA_ECOLI Pyrimidine monooxygenase RutA (EC 1.14.99.46) rutA ycdM b1012 JW0997 ycdM rutA 42,219 alkanesulfonate catabolic process [GO:0046306]; nitrogen utilization [GO:0019740]; pyrimidine nucleobase catabolic process [GO:0006208]; thymine catabolic process [GO:0006210]; uracil catabolic process [GO:0006212] alkanesulfonate monooxygenase activity [GO:0008726]; monooxygenase activity [GO:0004497]; uracil oxygenase activity [GO:0052614]; alkanesulfonate catabolic process [GO:0046306]; nitrogen utilization [GO:0019740]; pyrimidine nucleobase catabolic process [GO:0006208]; thymine catabolic process [GO:0006210]; uracil catabolic process [GO:0006212] alkanesulfonate monooxygenase activity [GO:0008726]; monooxygenase activity [GO:0004497]; uracil oxygenase activity [GO:0052614] GO:0004497; GO:0006208; GO:0006210; GO:0006212; GO:0008726; GO:0019740; GO:0046306; GO:0052614 +P77179 RSXE_ECOLI Ion-translocating oxidoreductase complex subunit E (EC 7.-.-.-) (Rsx electron transport complex subunit E) rsxE rnfE ydgQ b1632 JW1624 rnfE ydgQ rsxE 24,459 electron transport chain [GO:0022900] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; electron transport chain [GO:0022900] GO:0005886; GO:0016021; GO:0022900 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00478, ECO:0000269|PubMed:10411911, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00478, ECO:0000269|PubMed:15919996}. +P0AG99 SECG_ECOLI Protein-export membrane protein SecG (P12) (Preprotein translocase band 1 subunit) secG b3175 JW3142 secG 11,365 intracellular protein transmembrane transport [GO:0065002]; intracellular protein transport [GO:0006886]; protein insertion into membrane from inner side [GO:0032978]; protein secretion [GO:0009306]; protein transport by the Sec complex [GO:0043952]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616] cell envelope Sec protein transport complex [GO:0031522]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] cell envelope Sec protein transport complex [GO:0031522]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; P-P-bond-hydrolysis-driven protein transmembrane transporter activity [GO:0015450]; protein transmembrane transporter activity [GO:0008320]; intracellular protein transmembrane transport [GO:0065002]; intracellular protein transport [GO:0006886]; protein insertion into membrane from inner side [GO:0032978]; protein secretion [GO:0009306]; protein transport by the Sec complex [GO:0043952]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616] P-P-bond-hydrolysis-driven protein transmembrane transporter activity [GO:0015450]; protein transmembrane transporter activity [GO:0008320] GO:0005886; GO:0006616; GO:0006886; GO:0008320; GO:0009306; GO:0015450; GO:0016021; GO:0031522; GO:0032978; GO:0043952; GO:0065002 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P13458 SBCC_ECOLI Nuclease SbcCD subunit C sbcC rmuA b0397 JW0387 rmuA sbcC 118,721 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260] 3'-5'-exodeoxyribonuclease activity [GO:0008296]; ATP binding [GO:0005524]; double-stranded DNA endodeoxyribonuclease activity [GO:1990238]; exodeoxyribonuclease activity [GO:0004529]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260] 3'-5'-exodeoxyribonuclease activity [GO:0008296]; ATP binding [GO:0005524]; double-stranded DNA endodeoxyribonuclease activity [GO:1990238]; exodeoxyribonuclease activity [GO:0004529]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014] GO:0000014; GO:0004529; GO:0005524; GO:0006260; GO:0006281; GO:0006310; GO:0008296; GO:1990238 +P31675 SETA_ECOLI Sugar efflux transporter A setA yabM b0070 JW0069 yabM setA 42,713 carbohydrate transmembrane transport [GO:0034219]; cellular response to glucose-phosphate stress [GO:0036448]; glucose transmembrane transport [GO:1904659]; lactose transport [GO:0015767]; transmembrane transport [GO:0055085] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; carbohydrate:proton symporter activity [GO:0005351]; carbohydrate transmembrane transport [GO:0034219]; cellular response to glucose-phosphate stress [GO:0036448]; glucose transmembrane transport [GO:1904659]; lactose transport [GO:0015767]; transmembrane transport [GO:0055085] carbohydrate:proton symporter activity [GO:0005351] GO:0005351; GO:0005886; GO:0005887; GO:0015767; GO:0034219; GO:0036448; GO:0055085; GO:1904659 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77249 SFMC_ECOLI Probable fimbrial chaperone SfmC sfmC b0531 JW0520 sfmC 25,458 cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] GO:0030288; GO:0043711; GO:0061077; GO:0071555 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P39364 SGCQ_ECOLI Putative sgc region protein SgcQ sgcQ yjhM b4303 JW4265 yjhM sgcQ 29,355 catalytic activity [GO:0003824] catalytic activity [GO:0003824] GO:0003824 +P68191 SRA_ECOLI Stationary-phase-induced ribosome-associated protein (Protein D) (SRA) (30S ribosomal protein S22) sra rpsV b1480 JW5962 rpsV sra 5,096 translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412] structural constituent of ribosome [GO:0003735] GO:0003735; GO:0005829; GO:0006412; GO:0022627 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21903814}. Note=Enriched in the periphery of the cell, excluded from the nucleoid (PubMed:21903814). {ECO:0000269|PubMed:21903814}. +P00959 SYM_ECOLI Methionine--tRNA ligase (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) metG b2114 JW2101 metG 76,255 methionyl-tRNA aminoacylation [GO:0006431]; tRNA aminoacylation for protein translation [GO:0006418] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]; methionyl-tRNA aminoacylation [GO:0006431]; tRNA aminoacylation for protein translation [GO:0006418] ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] GO:0000049; GO:0004825; GO:0005524; GO:0005829; GO:0006418; GO:0006431; GO:0008270; GO:0016020 SUBCELLULAR LOCATION: Cytoplasm. +P23841 XAPR_ECOLI HTH-type transcriptional regulator XapR (Xanthosine operon regulatory protein) xapR pndR yfeB b2405 JW2396 pndR yfeB xapR 33,627 positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] protein-DNA complex [GO:0032993] protein-DNA complex [GO:0032993]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700] GO:0000986; GO:0003700; GO:0006355; GO:0032993; GO:0045893 +P0AAF1 POTE_ECOLI Putrescine transporter PotE (Putrescine-proton symporter / putrescine-ornithine antiporter) potE b0692 JW0679 potE 46,495 putrescine transport [GO:0015847] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; putrescine:ornithine antiporter activity [GO:0015496]; symporter activity [GO:0015293]; putrescine transport [GO:0015847] putrescine:ornithine antiporter activity [GO:0015496]; symporter activity [GO:0015293] GO:0005886; GO:0005887; GO:0015293; GO:0015496; GO:0015847 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02073, ECO:0000269|PubMed:9045651, ECO:0000305|PubMed:1939141}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02073}. +P31473 RAVA_ECOLI ATPase RavA (EC 3.6.3.-) (Regulatory ATPase variant A) ravA yieN b3746 JW3725 yieN ravA 56,389 cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; identical protein binding [GO:0042802] ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; identical protein binding [GO:0042802] GO:0005524; GO:0005737; GO:0005829; GO:0016887; GO:0042626; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm. +P0AG40 RIBF_ECOLI Bifunctional riboflavin kinase/FMN adenylyltransferase (Riboflavin biosynthesis protein RibF) [Includes: Riboflavin kinase (EC 2.7.1.26) (Flavokinase); FMN adenylyltransferase (EC 2.7.7.2) (FAD pyrophosphorylase) (FAD synthase)] ribF yaaC b0025 JW0023 yaaC ribF 34,734 FAD biosynthetic process [GO:0006747]; FMN biosynthetic process [GO:0009398]; riboflavin biosynthetic process [GO:0009231]; riboflavin metabolic process [GO:0006771] ATP binding [GO:0005524]; FMN adenylyltransferase activity [GO:0003919]; riboflavin kinase activity [GO:0008531]; FAD biosynthetic process [GO:0006747]; FMN biosynthetic process [GO:0009398]; riboflavin biosynthetic process [GO:0009231]; riboflavin metabolic process [GO:0006771] ATP binding [GO:0005524]; FMN adenylyltransferase activity [GO:0003919]; riboflavin kinase activity [GO:0008531] GO:0003919; GO:0005524; GO:0006747; GO:0006771; GO:0008531; GO:0009231; GO:0009398 +P77766 RNAAM_ECOLI 5'-3' exoribonuclease (EC 3.1.13.-) (3',5'-nucleotide bisphosphate phosphatase) (EC 3.1.3.97) (RNase AM) yciV trpH b1266 JW1258 trpH yciV 32,580 3',5'-nucleotide bisphosphate phosphatase activity [GO:0097657]; 5'-3' exodeoxyribonuclease activity [GO:0035312]; 5'-3' exoribonuclease activity [GO:0004534]; manganese ion binding [GO:0030145]; nucleotidase activity [GO:0008252]; nucleotide binding [GO:0000166] 3',5'-nucleotide bisphosphate phosphatase activity [GO:0097657]; 5'-3' exodeoxyribonuclease activity [GO:0035312]; 5'-3' exoribonuclease activity [GO:0004534]; manganese ion binding [GO:0030145]; nucleotidase activity [GO:0008252]; nucleotide binding [GO:0000166] GO:0000166; GO:0004534; GO:0008252; GO:0030145; GO:0035312; GO:0097657 +P0ACA3 SSPA_ECOLI Stringent starvation protein A sspA pog ssp b3229 JW3198 pog ssp sspA 24,305 glutathione metabolic process [GO:0006749]; positive regulation of transcription, DNA-templated [GO:0045893]; response to starvation [GO:0042594] cytosol [GO:0005829] cytosol [GO:0005829]; glutathione metabolic process [GO:0006749]; positive regulation of transcription, DNA-templated [GO:0045893]; response to starvation [GO:0042594] GO:0005829; GO:0006749; GO:0042594; GO:0045893 +P11866 TDCR_ECOLI Threonine dehydratase operon activator protein tdcR b3119 JW5525 tdcR 8,608 positive regulation of transcription, DNA-templated [GO:0045893] DNA binding [GO:0003677]; positive regulation of transcription, DNA-templated [GO:0045893] DNA binding [GO:0003677] GO:0003677; GO:0045893 +P0AF67 TSAE_ECOLI tRNA threonylcarbamoyladenosine biosynthesis protein TsaE (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE) tsaE yjeE b4168 JW4126 yjeE tsaE 16,853 protein autophosphorylation [GO:0046777]; tRNA threonylcarbamoyladenosine modification [GO:0002949] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein autophosphorylation [GO:0046777]; tRNA threonylcarbamoyladenosine modification [GO:0002949] ADP binding [GO:0043531]; ATPase activity [GO:0016887]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672] GO:0002949; GO:0004672; GO:0005524; GO:0005737; GO:0016887; GO:0042802; GO:0043531; GO:0046777; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19376873}. +P0A877 TRPA_ECOLI Tryptophan synthase alpha chain (EC 4.2.1.20) trpA b1260 JW1252 trpA 28,724 aromatic amino acid family biosynthetic process [GO:0009073]; tryptophan biosynthetic process [GO:0000162] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lyase activity [GO:0016829]; tryptophan synthase activity [GO:0004834]; aromatic amino acid family biosynthetic process [GO:0009073]; tryptophan biosynthetic process [GO:0000162] lyase activity [GO:0016829]; tryptophan synthase activity [GO:0004834] GO:0000162; GO:0004834; GO:0005737; GO:0005829; GO:0009073; GO:0016829 +P30235 PSUK_ECOLI Pseudouridine kinase (EC 2.7.1.83) psuK pscK yeiC b2166 JW2153 pscK yeiC psuK 33,573 ATP binding [GO:0005524]; pseudouridine kinase activity [GO:0050225] ATP binding [GO:0005524]; pseudouridine kinase activity [GO:0050225] GO:0005524; GO:0050225 +P33025 PSUG_ECOLI Pseudouridine-5'-phosphate glycosidase (PsiMP glycosidase) (EC 4.2.1.70) psuG pscG yeiN b2165 JW2152 pscG yeiN psuG 32,910 nucleobase catabolic process [GO:0046113] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; pseudouridylate synthase activity [GO:0004730]; nucleobase catabolic process [GO:0046113] hydrolase activity, acting on glycosyl bonds [GO:0016798]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; pseudouridylate synthase activity [GO:0004730] GO:0004730; GO:0016798; GO:0030145; GO:0032991; GO:0042802; GO:0046113 +P15639 PUR9_ECOLI Bifunctional purine biosynthesis protein PurH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)] purH b4006 JW3970 purH 57,329 'de novo' IMP biosynthetic process [GO:0006189] cytosol [GO:0005829] cytosol [GO:0005829]; IMP cyclohydrolase activity [GO:0003937]; phosphoribosylaminoimidazolecarboxamide formyltransferase activity [GO:0004643]; 'de novo' IMP biosynthetic process [GO:0006189] IMP cyclohydrolase activity [GO:0003937]; phosphoribosylaminoimidazolecarboxamide formyltransferase activity [GO:0004643] GO:0003937; GO:0004643; GO:0005829; GO:0006189 +P78061 PUUA_ECOLI Gamma-glutamylputrescine synthetase PuuA (Gamma-Glu-Put synthetase) (EC 6.3.1.11) (Glutamate--putrescine ligase) puuA ycjK b1297 JW5201 ycjK puuA 53,177 glutamine biosynthetic process [GO:0006542]; polyamine catabolic process [GO:0006598]; putrescine catabolic process [GO:0009447] ATP binding [GO:0005524]; glutamate-ammonia ligase activity [GO:0004356]; glutamate-putrescine ligase activity [GO:0034024]; glutamine biosynthetic process [GO:0006542]; polyamine catabolic process [GO:0006598]; putrescine catabolic process [GO:0009447] ATP binding [GO:0005524]; glutamate-ammonia ligase activity [GO:0004356]; glutamate-putrescine ligase activity [GO:0034024] GO:0004356; GO:0005524; GO:0006542; GO:0006598; GO:0009447; GO:0034024 +P0A7E3 PYRE_ECOLI Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10) pyrE b3642 JW3617 pyrE 23,567 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; pyrimidine nucleotide biosynthetic process [GO:0006221]; pyrimidine ribonucleoside biosynthetic process [GO:0046132] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; orotate phosphoribosyltransferase activity [GO:0004588]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; pyrimidine nucleotide biosynthetic process [GO:0006221]; pyrimidine ribonucleoside biosynthetic process [GO:0046132] magnesium ion binding [GO:0000287]; orotate phosphoribosyltransferase activity [GO:0004588] GO:0000287; GO:0004588; GO:0005737; GO:0005829; GO:0006207; GO:0006221; GO:0044205; GO:0046132 +P64530 RCNR_ECOLI Transcriptional repressor RcnR rcnR yohL b2105 JW2092 yohL rcnR 10,134 negative regulation of transcription, DNA-templated [GO:0045892] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GO:0003677; GO:0005737; GO:0045892; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P39288 QUEG_ECOLI Epoxyqueuosine reductase (EC 1.17.99.6) (Queuosine biosynthesis protein QueG) queG yjeS b4166 JW4124 yjeS queG 43,073 queuosine biosynthetic process [GO:0008616]; tRNA processing [GO:0008033] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 4 iron, 4 sulfur cluster binding [GO:0051539]; epoxyqueuosine reductase activity [GO:0052693]; metal ion binding [GO:0046872]; queuosine biosynthetic process [GO:0008616]; tRNA processing [GO:0008033] 4 iron, 4 sulfur cluster binding [GO:0051539]; epoxyqueuosine reductase activity [GO:0052693]; metal ion binding [GO:0046872] GO:0005737; GO:0008033; GO:0008616; GO:0046872; GO:0051539; GO:0052693 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00916}. +P0A7K2 RL7_ECOLI 50S ribosomal protein L7/L12 (L8) (Large ribosomal subunit protein bL12) rplL b3986 JW3949 rplL 12,295 translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934]; protein homodimerization activity [GO:0042803]; ribosome binding [GO:0043022]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412] protein homodimerization activity [GO:0042803]; ribosome binding [GO:0043022]; structural constituent of ribosome [GO:0003735] GO:0003735; GO:0005829; GO:0006412; GO:0015934; GO:0022625; GO:0042803; GO:0043022 +P0A7Z4 RPOA_ECOLI DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha) (EC 2.7.7.6) (RNA polymerase subunit alpha) (Transcriptase subunit alpha) rpoA pez phs sez b3295 JW3257 pez phs sez rpoA 36,512 transcription, DNA-templated [GO:0006351] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983] GO:0003677; GO:0003899; GO:0005737; GO:0005829; GO:0006351; GO:0016020; GO:0046983 +P77689 SUFD_ECOLI FeS cluster assembly protein SufD sufD ynhC b1681 JW1671 ynhC sufD 46,823 iron-sulfur cluster assembly [GO:0016226]; response to oxidative stress [GO:0006979] iron-sulfur cluster assembly complex [GO:1990229] iron-sulfur cluster assembly complex [GO:1990229]; iron-sulfur cluster assembly [GO:0016226]; response to oxidative stress [GO:0006979] GO:0006979; GO:0016226; GO:1990229 +P77626 SUTR_ECOLI HTH-type transcriptional regulator SutR (Sulfur utilization regulator) sutR ydcN b1434 JW1430 ydcN sutR 19,731 negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003677; GO:0003700; GO:0006355; GO:0043565; GO:0045892; GO:0045893 +P0ADG4 SUHB_ECOLI Nus factor SuhB (Inositol-1-monophosphatase) (I-1-Pase) (IMPase) (Inositol-1-phosphatase) (EC 3.1.3.25) suhB ssyA b2533 JW2517 ssyA suhB 29,172 inositol metabolic process [GO:0006020]; inositol phosphate dephosphorylation [GO:0046855]; phosphatidylinositol phosphorylation [GO:0046854]; ribosome biogenesis [GO:0042254]; signal transduction [GO:0007165]; transcription antitermination [GO:0031564] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glycerol-2-phosphatase activity [GO:0047954]; inositol monophosphate 1-phosphatase activity [GO:0008934]; inositol monophosphate 3-phosphatase activity [GO:0052832]; inositol monophosphate 4-phosphatase activity [GO:0052833]; lithium ion binding [GO:0031403]; magnesium ion binding [GO:0000287]; RNA binding [GO:0003723]; inositol metabolic process [GO:0006020]; inositol phosphate dephosphorylation [GO:0046855]; phosphatidylinositol phosphorylation [GO:0046854]; ribosome biogenesis [GO:0042254]; signal transduction [GO:0007165]; transcription antitermination [GO:0031564] glycerol-2-phosphatase activity [GO:0047954]; inositol monophosphate 1-phosphatase activity [GO:0008934]; inositol monophosphate 3-phosphatase activity [GO:0052832]; inositol monophosphate 4-phosphatase activity [GO:0052833]; lithium ion binding [GO:0031403]; magnesium ion binding [GO:0000287]; RNA binding [GO:0003723] GO:0000287; GO:0003723; GO:0005737; GO:0005829; GO:0006020; GO:0007165; GO:0008934; GO:0031403; GO:0031564; GO:0042254; GO:0046854; GO:0046855; GO:0047954; GO:0052832; GO:0052833 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:10747806}. +P00954 SYW_ECOLI Tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) trpS b3384 JW3347 trpS 37,438 tryptophanyl-tRNA aminoacylation [GO:0006436] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; tryptophan-tRNA ligase activity [GO:0004830]; tryptophanyl-tRNA aminoacylation [GO:0006436] ATP binding [GO:0005524]; tryptophan-tRNA ligase activity [GO:0004830] GO:0004830; GO:0005524; GO:0005829; GO:0006436 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00140}. +A5A627 TISB_ECOLI Small toxic protein TisB (LexA-regulated protein TisB) tisB ysdB b4618 JW3649 ysdB tisB 3,222 cellular response to DNA damage stimulus [GO:0006974]; dormancy process [GO:0022611]; SOS response [GO:0009432] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; anion channel activity [GO:0005253]; cellular response to DNA damage stimulus [GO:0006974]; dormancy process [GO:0022611]; SOS response [GO:0009432] anion channel activity [GO:0005253] GO:0005253; GO:0005887; GO:0006974; GO:0009432; GO:0016020; GO:0022611 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:18761622, ECO:0000269|PubMed:24513967}; Single-pass membrane protein {ECO:0000269|PubMed:18761622, ECO:0000269|PubMed:24513967}. +P77743 PRPR_ECOLI Propionate catabolism operon regulatory protein prpR yahP b0330 JW0322 yahP prpR 58,649 negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; propionate catabolic process, 2-methylcitrate cycle [GO:0019629]; response to radiation [GO:0009314] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; DNA-binding transcription factor activity [GO:0003700]; phosphorelay response regulator activity [GO:0000156]; sequence-specific DNA binding [GO:0043565]; transcription factor binding [GO:0008134]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; propionate catabolic process, 2-methylcitrate cycle [GO:0019629]; response to radiation [GO:0009314] ATP binding [GO:0005524]; DNA-binding transcription factor activity [GO:0003700]; phosphorelay response regulator activity [GO:0000156]; sequence-specific DNA binding [GO:0043565]; transcription factor binding [GO:0008134] GO:0000156; GO:0003700; GO:0005524; GO:0005737; GO:0008134; GO:0009314; GO:0019629; GO:0043565; GO:0045892; GO:0045893 +P69816 PTFB2_ECOLI PTS system fructose-like EIIB component 2 (EC 2.7.1.202) (Fructose-like phosphotransferase enzyme IIB component 2) frwB yijK b3950 JW3922 yijK frwB 11,248 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity [GO:0022877]; protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity [GO:0090582]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity [GO:0022877]; protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity [GO:0090582]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005737; GO:0005886; GO:0009401; GO:0016301; GO:0022877; GO:0090563; GO:0090582 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P42910 PTPC1_ECOLI N-acetylgalactosamine permease IIC component 1 (EIIC-Aga) (PTS system N-acetylgalactosamine-specific EIIC component 1) agaC yraE b3139 JW3108 yraE agaC 28,645 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] GO:0005886; GO:0005887; GO:0009401 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AFV8 PSPD_ECOLI Phage shock protein D pspD b1307 JW1300 pspD 8,042 phage shock [GO:0009271] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; phage shock [GO:0009271] GO:0005737; GO:0005886; GO:0009271 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12562786}. Cell inner membrane {ECO:0000269|PubMed:12562786}; Peripheral membrane protein {ECO:0000269|PubMed:12562786}; Cytoplasmic side {ECO:0000269|PubMed:12562786}. +P0AA67 RHTA_ECOLI Threonine/homoserine exporter RhtA rhtA ybiF b0813 JW0798 ybiF rhtA 31,168 homoserine transport [GO:0042968]; threonine transport [GO:0015826] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; homoserine transmembrane transporter activity [GO:0042970]; secondary active transmembrane transporter activity [GO:0015291]; threonine efflux transmembrane transporter activity [GO:0015565]; homoserine transport [GO:0042968]; threonine transport [GO:0015826] homoserine transmembrane transporter activity [GO:0042970]; secondary active transmembrane transporter activity [GO:0015291]; threonine efflux transmembrane transporter activity [GO:0015565] GO:0005886; GO:0005887; GO:0015291; GO:0015565; GO:0015826; GO:0016021; GO:0042968; GO:0042970 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:12648727}; Multi-pass membrane protein {ECO:0000269|PubMed:12648727}. +P0A7X6 RIMM_ECOLI Ribosome maturation factor RimM (21K) rimM yfjA b2608 JW5413 yfjA rimM 20,605 maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit assembly [GO:0000028] cytosol [GO:0005829]; ribosome [GO:0005840] cytosol [GO:0005829]; ribosome [GO:0005840]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843]; maturation of SSU-rRNA [GO:0030490]; ribosomal small subunit assembly [GO:0000028] ribosome binding [GO:0043022]; rRNA binding [GO:0019843] GO:0000028; GO:0005829; GO:0005840; GO:0019843; GO:0030490; GO:0043022 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11514519, ECO:0000269|PubMed:9226267}. Note=Binds 30S subunit, but not 70S ribosomes (PubMed:9226267). {ECO:0000269|PubMed:9226267}. +P0ADY7 RL16_ECOLI 50S ribosomal protein L16 (Large ribosomal subunit protein uL16) rplP b3313 JW3275 rplP 15,281 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] cytosolic large ribosomal subunit [GO:0022625]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049] GO:0000027; GO:0000049; GO:0003735; GO:0006412; GO:0019843; GO:0022625 +P0ADZ0 RL23_ECOLI 50S ribosomal protein L23 (Large ribosomal subunit protein uL23) rplW b3318 JW3280 rplW 11,199 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] cytosolic large ribosomal subunit [GO:0022625]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GO:0000027; GO:0003735; GO:0006412; GO:0019843; GO:0022625 +P0AG48 RL21_ECOLI 50S ribosomal protein L21 (Large ribosomal subunit protein bL21) rplU b3186 JW3153 rplU 11,564 translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GO:0003735; GO:0005829; GO:0006412; GO:0019843; GO:0022625 +P0ABG7 RODA_ECOLI Peptidoglycan glycosyltransferase MrdB (PGT) (EC 2.4.1.129) (Cell elongation protein RodA) (Cell wall polymerase) (Peptidoglycan polymerase) (PG polymerase) (Rod shape-determining protein) mrdB rodA b0634 JW0629 rodA mrdB 40,476 cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] cell division site [GO:0032153]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cell division site [GO:0032153]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; lipid-linked peptidoglycan transporter activity [GO:0015648]; peptidoglycan glycosyltransferase activity [GO:0008955]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] lipid-linked peptidoglycan transporter activity [GO:0015648]; peptidoglycan glycosyltransferase activity [GO:0008955] GO:0005886; GO:0005887; GO:0008360; GO:0008955; GO:0009252; GO:0015648; GO:0032153; GO:0051301; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02079, ECO:0000269|PubMed:6348029}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02079}. +P77768 RPNB_ECOLI Recombination-promoting nuclease RpnB (EC 3.1.21.-) rpnB yfcI b2305 JW2302 yfcI rpnB 34,179 DNA recombination [GO:0006310] double-stranded DNA endodeoxyribonuclease activity [GO:1990238]; DNA recombination [GO:0006310] double-stranded DNA endodeoxyribonuclease activity [GO:1990238] GO:0006310; GO:1990238 +P31665 RPNC_ECOLI Recombination-promoting nuclease RpnC (EC 3.1.21.-) rpnC yadD b0132 JW5010 yadD rpnC 34,607 DNA recombination [GO:0006310] double-stranded DNA endodeoxyribonuclease activity [GO:1990238]; DNA recombination [GO:0006310] double-stranded DNA endodeoxyribonuclease activity [GO:1990238] GO:0006310; GO:1990238 +P38105 RSPB_ECOLI Starvation-sensing protein RspB (EC 1.1.1.-) rspB b1580 JW1572 rspB 36,564 galactitol-1-phosphate 5-dehydrogenase activity [GO:0008868]; zinc ion binding [GO:0008270] galactitol-1-phosphate 5-dehydrogenase activity [GO:0008868]; zinc ion binding [GO:0008270] GO:0008270; GO:0008868 +P75719 RZPD_ECOLI Prophage Rz endopeptidase RzpD (EC 3.4.-.-) rzpD ybcT b0556 JW5079 ybcT rzpD 17,226 cytolysis [GO:0019835]; defense response to bacterium [GO:0042742]; viral release from host cell [GO:0019076] peptidase activity [GO:0008233]; cytolysis [GO:0019835]; defense response to bacterium [GO:0042742]; viral release from host cell [GO:0019076] peptidase activity [GO:0008233] GO:0008233; GO:0019076; GO:0019835; GO:0042742 +P39406 RSMC_ECOLI Ribosomal RNA small subunit methyltransferase C (EC 2.1.1.172) (16S rRNA m2G1207 methyltransferase) (rRNA (guanine-N(2)-)-methyltransferase RsmC) rsmC yjjT b4371 JW4333 yjjT rsmC 37,625 rRNA base methylation [GO:0070475]; rRNA methylation [GO:0031167] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; 16S rRNA (guanine(1207)-N(2))-methyltransferase activity [GO:0052914]; nucleic acid binding [GO:0003676]; rRNA (guanine-N2-)-methyltransferase activity [GO:0008990]; rRNA base methylation [GO:0070475]; rRNA methylation [GO:0031167] 16S rRNA (guanine(1207)-N(2))-methyltransferase activity [GO:0052914]; nucleic acid binding [GO:0003676]; rRNA (guanine-N2-)-methyltransferase activity [GO:0008990] GO:0003676; GO:0005737; GO:0005829; GO:0008990; GO:0031167; GO:0052914; GO:0070475 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P68567 RSMJ_ECOLI Ribosomal RNA small subunit methyltransferase J (EC 2.1.1.242) (16S rRNA m2G1516 methyltransferase) (rRNA (guanine-N(2)-)-methyltransferase) rsmJ yhiQ b3497 JW5672 yhiQ rsmJ 26,949 rRNA base methylation [GO:0070475]; rRNA methylation [GO:0031167] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 16S rRNA (guanine(1516)-N(2))-methyltransferase activity [GO:0036308]; rRNA (guanine-N2-)-methyltransferase activity [GO:0008990]; rRNA base methylation [GO:0070475]; rRNA methylation [GO:0031167] 16S rRNA (guanine(1516)-N(2))-methyltransferase activity [GO:0036308]; rRNA (guanine-N2-)-methyltransferase activity [GO:0008990] GO:0005737; GO:0008990; GO:0031167; GO:0036308; GO:0070475 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01523}. +P0ABW5 SFMA_ECOLI Uncharacterized fimbrial-like protein SfmA (Type-1A pilin) sfmA b0530 JW0519 sfmA 18,475 cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0007155; GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}. +P0A7F6 SPED_ECOLI S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase beta chain; S-adenosylmethionine decarboxylase alpha chain] speD b0120 JW0116 speD 30,385 S-adenosylmethioninamine biosynthetic process [GO:0006557]; spermidine biosynthetic process [GO:0008295] cytosol [GO:0005829] cytosol [GO:0005829]; adenosylmethionine decarboxylase activity [GO:0004014]; S-adenosylmethioninamine biosynthetic process [GO:0006557]; spermidine biosynthetic process [GO:0008295] adenosylmethionine decarboxylase activity [GO:0004014] GO:0004014; GO:0005829; GO:0006557; GO:0008295 +P0ACS2 SOXR_ECOLI Redox-sensitive transcriptional activator SoxR soxR marC b4063 JW4024 marC soxR 17,150 regulation of transcription, DNA-templated [GO:0006355]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 2 iron, 2 sulfur cluster binding [GO:0051537]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; regulation of transcription, DNA-templated [GO:0006355]; response to oxidative stress [GO:0006979] 2 iron, 2 sulfur cluster binding [GO:0051537]; DNA binding [GO:0003677]; metal ion binding [GO:0046872] GO:0003677; GO:0005737; GO:0006355; GO:0006979; GO:0046872; GO:0051537 +P37680 SGBE_ECOLI L-ribulose-5-phosphate 4-epimerase SgbE (EC 5.1.3.4) (Phosphoribulose isomerase) sgbE yiaS b3583 JW3555 yiaS sgbE 25,561 L-arabinose catabolic process [GO:0019572]; L-lyxose metabolic process [GO:0019324]; pentose catabolic process [GO:0019323] cytosol [GO:0005829] cytosol [GO:0005829]; aldehyde-lyase activity [GO:0016832]; L-ribulose-phosphate 4-epimerase activity [GO:0008742]; zinc ion binding [GO:0008270]; L-arabinose catabolic process [GO:0019572]; L-lyxose metabolic process [GO:0019324]; pentose catabolic process [GO:0019323] aldehyde-lyase activity [GO:0016832]; L-ribulose-phosphate 4-epimerase activity [GO:0008742]; zinc ion binding [GO:0008270] GO:0005829; GO:0008270; GO:0008742; GO:0016832; GO:0019323; GO:0019324; GO:0019572 +P37678 SGBH_ECOLI 3-keto-L-gulonate-6-phosphate decarboxylase SgbH (KGPDC) (EC 4.1.1.85) (3-dehydro-L-gulonate-6-phosphate decarboxylase) sgbH yiaQ b3581 JW3553 yiaQ sgbH 23,445 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; carbohydrate catabolic process [GO:0016052]; L-ascorbic acid catabolic process [GO:0019854] 3-dehydro-L-gulonate-6-phosphate decarboxylase activity [GO:0033982]; metal ion binding [GO:0046872]; orotidine-5'-phosphate decarboxylase activity [GO:0004590]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; carbohydrate catabolic process [GO:0016052]; L-ascorbic acid catabolic process [GO:0019854] 3-dehydro-L-gulonate-6-phosphate decarboxylase activity [GO:0033982]; metal ion binding [GO:0046872]; orotidine-5'-phosphate decarboxylase activity [GO:0004590] GO:0004590; GO:0006207; GO:0016052; GO:0019854; GO:0033982; GO:0046872 +P75869 SXY_ECOLI Protein Sxy (Competence activator Sxy) sxy tfoX yccR b0959 JW0942 tfoX yccR sxy 24,147 DNA import into cell involved in transformation [GO:0009290]; establishment of competence for transformation [GO:0030420]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of type IV pilus biogenesis [GO:1903658]; regulation of DNA-binding transcription factor activity [GO:0051090] DNA import into cell involved in transformation [GO:0009290]; establishment of competence for transformation [GO:0030420]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of type IV pilus biogenesis [GO:1903658]; regulation of DNA-binding transcription factor activity [GO:0051090] GO:0009290; GO:0030420; GO:0051090; GO:0051091; GO:1903658 +P29208 MENC_ECOLI o-succinylbenzoate synthase (OSB synthase) (OSBS) (EC 4.2.1.113) (4-(2'-carboxyphenyl)-4-oxybutyric acid synthase) (o-succinylbenzoic acid synthase) menC b2261 JW2256 menC 35,477 menaquinone biosynthetic process [GO:0009234] hydro-lyase activity [GO:0016836]; magnesium ion binding [GO:0000287]; O-succinylbenzoate synthase activity [GO:0043748]; menaquinone biosynthetic process [GO:0009234] hydro-lyase activity [GO:0016836]; magnesium ion binding [GO:0000287]; O-succinylbenzoate synthase activity [GO:0043748] GO:0000287; GO:0009234; GO:0016836; GO:0043748 +P0A935 MLTA_ECOLI Membrane-bound lytic murein transglycosylase A (EC 4.2.2.n1) (Mlt38) (Murein hydrolase A) mltA mlt ygdM b2813 JW2784 mlt ygdM mltA 40,411 cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253]; peptidoglycan turnover [GO:0009254] anchored component of cell outer membrane [GO:0036405]; cell outer membrane [GO:0009279]; integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288] anchored component of cell outer membrane [GO:0036405]; cell outer membrane [GO:0009279]; integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; lyase activity [GO:0016829]; lytic transglycosylase activity [GO:0008933]; cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253]; peptidoglycan turnover [GO:0009254] hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; lyase activity [GO:0016829]; lytic transglycosylase activity [GO:0008933] GO:0004553; GO:0005887; GO:0008933; GO:0009253; GO:0009254; GO:0009279; GO:0016829; GO:0030288; GO:0036405; GO:0071555 SUBCELLULAR LOCATION: Cell outer membrane; Lipid-anchor. +P0AF10 MTLR_ECOLI Mannitol operon repressor (Mannitol repressor protein) mtlR b3601 JW3575 mtlR 21,990 negative regulation of transcription, DNA-templated [GO:0045892] negative regulation of transcription, DNA-templated [GO:0045892] GO:0045892 +P46022 MTGA_ECOLI Biosynthetic peptidoglycan transglycosylase (EC 2.4.1.129) (Glycan polymerase) (Monofunctional biosynthetic peptidoglycan transglycosylase) (Monofunctional glycosyltransferase) (Monofunctional GTase) (Peptidoglycan glycosyltransferase MtgA) (PGT) mtgA mgt yrbM b3208 JW3175 mgt yrbM mtgA 27,342 cell wall organization [GO:0071555]; Gram-negative-bacterium-type cell wall biogenesis [GO:0043164]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] integral component of membrane [GO:0016021]; peptidoglycan-based cell wall [GO:0009274]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; peptidoglycan-based cell wall [GO:0009274]; plasma membrane [GO:0005886]; peptidoglycan glycosyltransferase activity [GO:0008955]; transferase activity, transferring pentosyl groups [GO:0016763]; cell wall organization [GO:0071555]; Gram-negative-bacterium-type cell wall biogenesis [GO:0043164]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] peptidoglycan glycosyltransferase activity [GO:0008955]; transferase activity, transferring pentosyl groups [GO:0016763] GO:0005886; GO:0008360; GO:0008955; GO:0009252; GO:0009274; GO:0016021; GO:0016763; GO:0043164; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00766, ECO:0000269|PubMed:8772200}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00766}. Note=Localizes to the cell division site. {ECO:0000269|PubMed:18165305}. +P19319 NARZ_ECOLI Respiratory nitrate reductase 2 alpha chain (EC 1.7.5.1) narZ b1468 JW1463 narZ 140,227 anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061]; nitrate assimilation [GO:0042128] membrane [GO:0016020]; nitrate reductase complex [GO:0009325]; plasma membrane [GO:0005886] membrane [GO:0016020]; nitrate reductase complex [GO:0009325]; plasma membrane [GO:0005886]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; molybdopterin cofactor binding [GO:0043546]; nitrate reductase activity [GO:0008940]; anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061]; nitrate assimilation [GO:0042128] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; molybdopterin cofactor binding [GO:0043546]; nitrate reductase activity [GO:0008940] GO:0005886; GO:0008940; GO:0009061; GO:0009325; GO:0016020; GO:0019645; GO:0042128; GO:0043546; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. +P40710 NLPE_ECOLI Lipoprotein NlpE (Copper homeostasis protein CutF) nlpE cutF b0192 JW0188 cutF nlpE 25,844 cell adhesion [GO:0007155]; regulation of cell-substrate adhesion [GO:0010810]; stress response to copper ion [GO:1990169] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; identical protein binding [GO:0042802]; cell adhesion [GO:0007155]; regulation of cell-substrate adhesion [GO:0010810]; stress response to copper ion [GO:1990169] identical protein binding [GO:0042802] GO:0007155; GO:0009279; GO:0010810; GO:0042802; GO:1990169 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:15252048, ECO:0000305|PubMed:7635808}; Lipid-anchor {ECO:0000305|PubMed:15252048, ECO:0000305|PubMed:7635808}. +P0A915 OMPW_ECOLI Outer membrane protein W ompW yciD b1256 JW1248 yciD ompW 22,928 transmembrane transport [GO:0055085] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; transmembrane transport [GO:0055085] GO:0009279; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell outer membrane. +P40120 OPGD_ECOLI Glucans biosynthesis protein D mdoD opgD ydcG yzzZ b1424 JW1420 opgD ydcG yzzZ mdoD 62,758 beta-glucan biosynthetic process [GO:0051274] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; carbohydrate binding [GO:0030246]; catalytic activity [GO:0003824]; beta-glucan biosynthetic process [GO:0051274] carbohydrate binding [GO:0030246]; catalytic activity [GO:0003824] GO:0003824; GO:0030246; GO:0030288; GO:0051274 SUBCELLULAR LOCATION: Periplasm. +P0DP70 PHNE2_ECOLI Putative cryptic phosphonate transport system permease protein PhnE2 phnE phnE2 b4103 JW4065 phnE2 phnE 13,335 organic phosphonate transport [GO:0015716]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; organic phosphonate transport [GO:0015716]; transmembrane transport [GO:0055085] GO:0005886; GO:0015716; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:15919996}. Note=In strain K12 / MG1655 when overexpressed using vectors that provide a promoter and ribosome binding site (PubMed:15919996). {ECO:0000269|PubMed:15919996}. +Q46755 SIRB2_ECOLI Protein YchQ (Protein SirB2) ychQ sirB2 b1213 JW1204 sirB2 ychQ 14,639 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P39361 SGCR_ECOLI Putative sgc region transcriptional regulator sgcR yjhJ b4300 JW4262 yjhJ sgcR 29,268 DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700 +P0AEU7 SKP_ECOLI Chaperone protein Skp (DNA-binding 17 kDa protein) (Histone-like protein HLP-1) (Seventeen kilodalton protein) skp hlpA ompH b0178 JW0173 hlpA ompH skp 17,688 chaperone-mediated protein folding [GO:0061077]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; protein folding [GO:0006457]; protein insertion into membrane from inner side [GO:0032978]; protein maturation by protein folding [GO:0022417]; protein stabilization [GO:0050821] cytosol [GO:0005829]; outer membrane-bounded periplasmic space [GO:0030288] cytosol [GO:0005829]; outer membrane-bounded periplasmic space [GO:0030288]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; unfolded protein binding [GO:0051082]; chaperone-mediated protein folding [GO:0061077]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; protein folding [GO:0006457]; protein insertion into membrane from inner side [GO:0032978]; protein maturation by protein folding [GO:0022417]; protein stabilization [GO:0050821] identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; unfolded protein binding [GO:0051082] GO:0001530; GO:0005829; GO:0006457; GO:0022417; GO:0030288; GO:0032978; GO:0042802; GO:0043165; GO:0050821; GO:0051082; GO:0061077 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:1838129, ECO:0000269|PubMed:8730870}. +P21507 SRMB_ECOLI ATP-dependent RNA helicase SrmB (EC 3.6.4.13) srmB rbaB rhlA b2576 JW2560 rbaB rhlA srmB 49,914 ribosomal large subunit assembly [GO:0000027] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase activity, acting on RNA [GO:0008186]; poly(A) binding [GO:0008143]; RNA helicase activity [GO:0003724]; RNA strand annealing activity [GO:0033592]; ribosomal large subunit assembly [GO:0000027] ATPase activity [GO:0016887]; ATPase activity, acting on RNA [GO:0008186]; ATP binding [GO:0005524]; poly(A) binding [GO:0008143]; RNA helicase activity [GO:0003724]; RNA strand annealing activity [GO:0033592] GO:0000027; GO:0003724; GO:0005524; GO:0005829; GO:0008143; GO:0008186; GO:0016887; GO:0033592 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00967}. +P0AFZ3 SSPB_ECOLI Stringent starvation protein B (Adapter protein SspB) (Specificity-enhancing factor SspB) sspB b3228 JW3197 sspB 18,262 positive regulation of ATPase activity [GO:0032781]; positive regulation of protein catabolic process [GO:0045732] cytosol [GO:0005829]; HslUV protease complex [GO:0009376]; ribosome [GO:0005840] cytosol [GO:0005829]; HslUV protease complex [GO:0009376]; ribosome [GO:0005840]; ATPase binding [GO:0051117]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; positive regulation of ATPase activity [GO:0032781]; positive regulation of protein catabolic process [GO:0045732] ATPase binding [GO:0051117]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] GO:0003723; GO:0005829; GO:0005840; GO:0009376; GO:0032781; GO:0042803; GO:0045732; GO:0051117 +P08395 SPPA_ECOLI Protease 4 (EC 3.4.21.-) (Endopeptidase IV) (Protease IV) (Signal peptide peptidase) sppA b1766 JW1755 sppA 67,219 signal peptide processing [GO:0006465] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; endopeptidase activity [GO:0004175]; serine-type peptidase activity [GO:0008236]; signal peptide processing [GO:0006465] endopeptidase activity [GO:0004175]; serine-type peptidase activity [GO:0008236] GO:0004175; GO:0005886; GO:0005887; GO:0006465; GO:0008236; GO:0016020 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:18476724, ECO:0000269|PubMed:3522590}; Single-pass membrane protein {ECO:0000269|PubMed:18476724, ECO:0000269|PubMed:3522590}. +P25397 TEHB_ECOLI Tellurite methyltransferase (EC 2.1.1.265) (Chalcogen-detoxifying protein TehB) (Selenite methyltransferase) (Tellurite resistance protein TehB) tehB b1430 JW1426 tehB 22,531 methylation [GO:0032259]; response to antibiotic [GO:0046677]; response to tellurium ion [GO:0046690]; response to toxic substance [GO:0009636] cytosol [GO:0005829] cytosol [GO:0005829]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; methylation [GO:0032259]; response to antibiotic [GO:0046677]; response to tellurium ion [GO:0046690]; response to toxic substance [GO:0009636] S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] GO:0005829; GO:0008757; GO:0009636; GO:0032259; GO:0046677; GO:0046690 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:11053398}. Note=Probably a peripheral membrane protein that interacts with TehA. +P0A881 TRPR_ECOLI Trp operon repressor trpR rtrY b4393 JW4356 rtrY trpR 12,355 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003677; GO:0003700; GO:0005737; GO:0006355; GO:0043565; GO:0045892 SUBCELLULAR LOCATION: Cytoplasm. +P0A7B5 PROB_ECOLI Glutamate 5-kinase (EC 2.7.2.11) (Gamma-glutamyl kinase) (GK) proB b0242 JW0232 proB 39,057 L-proline biosynthetic process [GO:0055129]; proline biosynthetic process [GO:0006561] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; glutamate 5-kinase activity [GO:0004349]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; proline binding [GO:1901973]; RNA binding [GO:0003723]; L-proline biosynthetic process [GO:0055129]; proline biosynthetic process [GO:0006561] ATP binding [GO:0005524]; glutamate 5-kinase activity [GO:0004349]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; proline binding [GO:1901973]; RNA binding [GO:0003723] GO:0000287; GO:0003723; GO:0004349; GO:0005524; GO:0005829; GO:0006561; GO:0042802; GO:0055129; GO:1901973 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00456}. +P31660 PRPC_ECOLI 2-methylcitrate synthase (2-MCS) (MCS) (EC 2.3.3.5) ((2S,3S)-2-methylcitrate synthase) (Citrate synthase) (EC 2.3.3.16) prpC yahS yzzD b0333 JW0324 yahS yzzD prpC 43,102 carbohydrate metabolic process [GO:0005975]; propionate metabolic process, methylcitrate cycle [GO:0019679]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 2-methylcitrate synthase activity [GO:0050440]; citrate (Si)-synthase activity [GO:0004108]; carbohydrate metabolic process [GO:0005975]; propionate metabolic process, methylcitrate cycle [GO:0019679]; tricarboxylic acid cycle [GO:0006099] 2-methylcitrate synthase activity [GO:0050440]; citrate (Si)-synthase activity [GO:0004108] GO:0004108; GO:0005737; GO:0005975; GO:0006099; GO:0019679; GO:0050440 +P07654 PSTA_ECOLI Phosphate transport system permease protein PstA pstA phoT b3726 JW3704 phoT pstA 32,322 cellular response to DNA damage stimulus [GO:0006974]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; regulation of phosphatase activity [GO:0010921] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; inorganic phosphate transmembrane transporter activity [GO:0005315]; cellular response to DNA damage stimulus [GO:0006974]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; regulation of phosphatase activity [GO:0010921] inorganic phosphate transmembrane transporter activity [GO:0005315] GO:0005315; GO:0005887; GO:0006817; GO:0006974; GO:0010921; GO:0035435 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:15919996}. +P05020 PYRC_ECOLI Dihydroorotase (DHOase) (EC 3.5.2.3) pyrC b1062 JW1049 pyrC 38,827 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; pyrimidine nucleotide biosynthetic process [GO:0006221] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dihydroorotase activity [GO:0004151]; zinc ion binding [GO:0008270]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; pyrimidine nucleotide biosynthetic process [GO:0006221] dihydroorotase activity [GO:0004151]; zinc ion binding [GO:0008270] GO:0004151; GO:0005737; GO:0005829; GO:0006207; GO:0006221; GO:0008270; GO:0044205 +P0A7L0 RL1_ECOLI 50S ribosomal protein L1 (Large ribosomal subunit protein uL1) rplA b3984 JW3947 rplA 24,730 maturation of LSU-rRNA [GO:0000470]; negative regulation of translational initiation [GO:0045947]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049]; maturation of LSU-rRNA [GO:0000470]; negative regulation of translational initiation [GO:0045947]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049] GO:0000027; GO:0000049; GO:0000470; GO:0003723; GO:0003735; GO:0005829; GO:0006412; GO:0019843; GO:0022625; GO:0045947 +P0A7S9 RS13_ECOLI 30S ribosomal protein S13 (Small ribosomal subunit protein uS13) rpsM b3298 JW3260 rpsM 13,099 translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049]; translation [GO:0006412] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049] GO:0000049; GO:0003735; GO:0005829; GO:0006412; GO:0015935; GO:0019843; GO:0022627 +P00448 SODM_ECOLI Superoxide dismutase [Mn] (EC 1.15.1.1) (MnSOD) sodA b3908 JW3879 sodA 23,097 cellular response to selenium ion [GO:0071291]; removal of superoxide radicals [GO:0019430]; response to acidic pH [GO:0010447]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]; superoxide metabolic process [GO:0006801] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; antioxidant activity [GO:0016209]; DNA binding [GO:0003677]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; superoxide dismutase activity [GO:0004784]; cellular response to selenium ion [GO:0071291]; removal of superoxide radicals [GO:0019430]; response to acidic pH [GO:0010447]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]; superoxide metabolic process [GO:0006801] antioxidant activity [GO:0016209]; DNA binding [GO:0003677]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; superoxide dismutase activity [GO:0004784] GO:0003677; GO:0004784; GO:0005737; GO:0005829; GO:0006801; GO:0006979; GO:0009408; GO:0010447; GO:0016209; GO:0019430; GO:0030145; GO:0046872; GO:0071291 +P37679 SGBU_ECOLI Putative L-ribulose-5-phosphate 3-epimerase SgbU (EC 5.1.3.22) (L-xylulose-5-phosphate 3-epimerase) sgbU yiaR b3582 JW5650 yiaR sgbU 32,455 DNA repair [GO:0006281]; L-ascorbic acid metabolic process [GO:0019852]; L-lyxose metabolic process [GO:0019324] DNA binding [GO:0003677]; intramolecular oxidoreductase activity, interconverting aldoses and ketoses [GO:0016861]; L-ribulose-5-phosphate 3-epimerase activity [GO:0034015]; zinc ion binding [GO:0008270]; DNA repair [GO:0006281]; L-ascorbic acid metabolic process [GO:0019852]; L-lyxose metabolic process [GO:0019324] DNA binding [GO:0003677]; intramolecular oxidoreductase activity, interconverting aldoses and ketoses [GO:0016861]; L-ribulose-5-phosphate 3-epimerase activity [GO:0034015]; zinc ion binding [GO:0008270] GO:0003677; GO:0006281; GO:0008270; GO:0016861; GO:0019324; GO:0019852; GO:0034015 +P0AG78 SUBI_ECOLI Sulfate-binding protein (Sulfate starvation-induced protein 2) (SSI2) sbp b3917 JW3888 sbp 36,659 sulfate transport [GO:0008272]; sulfur compound metabolic process [GO:0006790] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; ABC-type sulfate transporter activity [GO:0015419]; sulfate binding [GO:0043199]; sulfate transport [GO:0008272]; sulfur compound metabolic process [GO:0006790] ABC-type sulfate transporter activity [GO:0015419]; sulfate binding [GO:0043199] GO:0006790; GO:0008272; GO:0015419; GO:0030288; GO:0043199 SUBCELLULAR LOCATION: Periplasm. +P80644 SSUE_ECOLI FMN reductase (NADPH) (EC 1.5.1.38) (FMN reductase) (Sulfate starvation-induced protein 4) (SSI4) ssuE ycbP b0937 JW0920 ycbP ssuE 21,253 alkanesulfonate catabolic process [GO:0046306]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to sulfate starvation [GO:0009970] FMN reductase complex [GO:1990202] FMN reductase complex [GO:1990202]; FMN reductase (NADPH) activity [GO:0052873]; FMN reductase activity [GO:0008752]; alkanesulfonate catabolic process [GO:0046306]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to sulfate starvation [GO:0009970] FMN reductase (NADPH) activity [GO:0052873]; FMN reductase activity [GO:0008752] GO:0006974; GO:0008752; GO:0009970; GO:0046306; GO:0052873; GO:1990202 +P32138 SQASE_ECOLI Sulfoquinovosidase (SQase) (EC 3.2.1.199) yihQ squQ b3878 JW3849 squQ yihQ 77,275 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde [GO:0061720]; carbohydrate metabolic process [GO:0005975] carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; sulfoquinovosidase activity [GO:1990929]; 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde [GO:0061720]; carbohydrate metabolic process [GO:0005975] carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; sulfoquinovosidase activity [GO:1990929] GO:0004553; GO:0005975; GO:0030246; GO:0061720; GO:1990929 +P04152 UMUC_ECOLI Protein UmuC (DNA polymerase V) (Pol V) umuC b1184 JW1173 umuC 47,680 cellular response to DNA damage stimulus [GO:0006974]; error-prone translesion synthesis [GO:0042276]; SOS response [GO:0009432]; translesion synthesis [GO:0019985] DNA polymerase V complex [GO:0009355]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] DNA polymerase V complex [GO:0009355]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATPase activity, acting on DNA [GO:0008094]; damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; single-stranded DNA binding [GO:0003697]; cellular response to DNA damage stimulus [GO:0006974]; error-prone translesion synthesis [GO:0042276]; SOS response [GO:0009432]; translesion synthesis [GO:0019985] ATPase activity, acting on DNA [GO:0008094]; damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; single-stranded DNA binding [GO:0003697] GO:0003684; GO:0003697; GO:0003887; GO:0005886; GO:0006974; GO:0008094; GO:0009355; GO:0009432; GO:0016020; GO:0016021; GO:0019985; GO:0042276 +Q46836 PPPA_ECOLI Prepilin peptidase PppA pppA yghH b2972 JW2939 yghH pppA 29,466 signal peptide processing [GO:0006465] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175]; signal peptide processing [GO:0006465] aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175] GO:0004175; GO:0004190; GO:0005886; GO:0006465; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein. +P0A9L5 PPIC_ECOLI Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC 5.2.1.8) (Par10) (Parvulin) (Rotamase C) ppiC parVA b3775 JW3748 parVA ppiC 10,232 cytoplasm [GO:0005737] cytoplasm [GO:0005737]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] GO:0003755; GO:0005737 SUBCELLULAR LOCATION: Cytoplasm. +P69824 PTMA_ECOLI Mannitol-specific cryptic phosphotransferase enzyme IIA component (EIIA-Mtl) (EIII-Mtl) (PTS system mannitol-specific EIIA component) cmtB b2934 JW2901 cmtB 16,046 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; kinase activity [GO:0016301]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301] GO:0005737; GO:0009401; GO:0016301 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A7C8 PSIE_ECOLI Protein PsiE psiE yjbA b4030 JW3990 yjbA psiE 15,597 cellular response to phosphate starvation [GO:0016036] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cellular response to phosphate starvation [GO:0016036] GO:0005886; GO:0016021; GO:0016036 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A786 PYRB_ECOLI Aspartate carbamoyltransferase catalytic subunit (EC 2.1.3.2) (Aspartate transcarbamylase) (ATCase) pyrB b4245 JW4204 pyrB 34,427 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; cellular amino acid metabolic process [GO:0006520]; nitrogen compound metabolic process [GO:0006807]; protein homotrimerization [GO:0070207] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; amino acid binding [GO:0016597]; aspartate carbamoyltransferase activity [GO:0004070]; identical protein binding [GO:0042802]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; cellular amino acid metabolic process [GO:0006520]; nitrogen compound metabolic process [GO:0006807]; protein homotrimerization [GO:0070207] amino acid binding [GO:0016597]; aspartate carbamoyltransferase activity [GO:0004070]; identical protein binding [GO:0042802] GO:0004070; GO:0005737; GO:0005829; GO:0006207; GO:0006520; GO:0006807; GO:0016597; GO:0042802; GO:0044205; GO:0070207 +P0A7G6 RECA_ECOLI Protein RecA (Recombinase A) recA lexB recH rnmB tif umuB zab b2699 JW2669 lexB recH rnmB tif umuB zab recA 37,973 cell motility [GO:0048870]; cellular response to DNA damage stimulus [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; response to ionizing radiation [GO:0010212]; response to radiation [GO:0009314]; SOS response [GO:0009432] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; ATPase activity, acting on DNA [GO:0008094]; damaged DNA binding [GO:0003684]; single-stranded DNA binding [GO:0003697]; cell motility [GO:0048870]; cellular response to DNA damage stimulus [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; response to ionizing radiation [GO:0010212]; response to radiation [GO:0009314]; SOS response [GO:0009432] ATPase activity, acting on DNA [GO:0008094]; ATP binding [GO:0005524]; damaged DNA binding [GO:0003684]; single-stranded DNA binding [GO:0003697] GO:0003684; GO:0003697; GO:0005524; GO:0005737; GO:0006281; GO:0006310; GO:0006974; GO:0008094; GO:0009314; GO:0009432; GO:0010212; GO:0048870 SUBCELLULAR LOCATION: Cytoplasm. +P27844 RARD_ECOLI Protein RarD rarD b3819 JW5589 rarD 33,283 integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] GO:0005886; GO:0005887; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P60240 RAPA_ECOLI RNA polymerase-associated protein RapA (EC 3.6.4.-) (ATP-dependent helicase HepA) rapA hepA yabA b0059 JW0058 hepA yabA rapA 109,769 positive regulation of transcription, DNA-templated [GO:0045893] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; bacterial-type RNA polymerase core enzyme binding [GO:0001000]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676]; nucleosome-dependent ATPase activity [GO:0070615]; positive regulation of transcription, DNA-templated [GO:0045893] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; bacterial-type RNA polymerase core enzyme binding [GO:0001000]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676]; nucleosome-dependent ATPase activity [GO:0070615] GO:0001000; GO:0003676; GO:0003677; GO:0004386; GO:0005524; GO:0005737; GO:0016887; GO:0045893; GO:0070615 +P30176 RIBX_ECOLI N-glycosidase YbiA (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) ybiA b0798 JW0783 ybiA 18,669 carbohydrate derivative metabolic process [GO:1901135]; nucleobase-containing small molecule catabolic process [GO:0034656]; riboflavin biosynthetic process [GO:0009231] hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]; carbohydrate derivative metabolic process [GO:1901135]; nucleobase-containing small molecule catabolic process [GO:0034656]; riboflavin biosynthetic process [GO:0009231] hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799] GO:0009231; GO:0016799; GO:0034656; GO:1901135 +P37692 RFAF_ECOLI ADP-heptose--LPS heptosyltransferase 2 (EC 2.-.-.-) (ADP-heptose--LPS heptosyltransferase II) rfaF waaF b3620 JW3595 waaF rfaF 39,042 lipopolysaccharide core region biosynthetic process [GO:0009244] cytosol [GO:0005829] cytosol [GO:0005829]; ADP-heptose-lipopolysaccharide heptosyltransferase activity [GO:0008713]; lipopolysaccharide core region biosynthetic process [GO:0009244] ADP-heptose-lipopolysaccharide heptosyltransferase activity [GO:0008713] GO:0005829; GO:0008713; GO:0009244 +P75718 REND_ECOLI Putative protein RenD (Putative defective protein Ren from DLP12 prophage) renD b0542 JW0530 renD 7,173 +P0A6A0 UBIB_ECOLI Probable protein kinase UbiB (EC 2.7.-.-) (Ubiquinone biosynthesis protein UbiB) ubiB aarF yigQ yigR yigS b3835 JW3812 aarF yigQ yigR yigS ubiB 63,203 regulation of ubiquinone biosynthetic process [GO:0010795]; ubiquinone biosynthetic process [GO:0006744] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; regulation of ubiquinone biosynthetic process [GO:0010795]; ubiquinone biosynthetic process [GO:0006744] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] GO:0004672; GO:0005524; GO:0005886; GO:0006744; GO:0010795; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00414, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00414, ECO:0000269|PubMed:15919996}. +P0AGI4 XYLH_ECOLI Xylose transport system permease protein XylH xylH b3568 JW3540 xylH 41,031 carbohydrate transport [GO:0008643]; D-xylose metabolic process [GO:0042732] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; carbohydrate transport [GO:0008643]; D-xylose metabolic process [GO:0042732] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0008643; GO:0016021; GO:0022857; GO:0042732 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P71243 WCAL_ECOLI Putative colanic acid biosynthesis glycosyltransferase WcaL (EC 2.4.-.-) wcaL yefL b2044 JW2029 yefL wcaL 45,362 colanic acid metabolic process [GO:0046377]; lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] transferase activity, transferring glycosyl groups [GO:0016757]; colanic acid metabolic process [GO:0046377]; lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] transferase activity, transferring glycosyl groups [GO:0016757] GO:0009103; GO:0016757; GO:0045228; GO:0046377 +P76002 PLIG_ECOLI Inhibitor of g-type lysozyme pliG ycgK b1178 JW1167 ycgK pliG 14,906 cytosol [GO:0005829]; periplasmic space [GO:0042597] cytosol [GO:0005829]; periplasmic space [GO:0042597]; lysozyme inhibitor activity [GO:0060241] lysozyme inhibitor activity [GO:0060241] GO:0005829; GO:0042597; GO:0060241 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:20734102}. +P02338 PRTL_ECOLI Protamine-like protein tpr b1229 JW1219 tpr 3,447 +P68679 RS21_ECOLI 30S ribosomal protein S21 (Small ribosomal subunit protein bS21) rpsU b3065 JW3037 rpsU 8,500 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GO:0000028; GO:0003735; GO:0005829; GO:0006412; GO:0019843; GO:0022627 +P0A8N5 SYK2_ECOLI Lysine--tRNA ligase, heat inducible (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) lysU b4129 JW4090 lysU 57,827 lysyl-tRNA aminoacylation [GO:0006430]; tRNA aminoacylation for protein translation [GO:0006418] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; ligase activity [GO:0016874]; lysine-tRNA ligase activity [GO:0004824]; magnesium ion binding [GO:0000287]; tRNA binding [GO:0000049]; lysyl-tRNA aminoacylation [GO:0006430]; tRNA aminoacylation for protein translation [GO:0006418] ATP binding [GO:0005524]; ligase activity [GO:0016874]; lysine-tRNA ligase activity [GO:0004824]; magnesium ion binding [GO:0000287]; tRNA binding [GO:0000049] GO:0000049; GO:0000287; GO:0004824; GO:0005524; GO:0005829; GO:0006418; GO:0006430; GO:0016020; GO:0016874 SUBCELLULAR LOCATION: Cytoplasm. +P16659 SYP_ECOLI Proline--tRNA ligase (EC 6.1.1.15) (Global RNA synthesis factor) (Prolyl-tRNA synthetase) (ProRS) proS drpA b0194 JW0190 drpA proS 63,693 prolyl-tRNA aminoacylation [GO:0006433] cytosol [GO:0005829] cytosol [GO:0005829]; Ala-tRNA(Pro) hydrolase activity [GO:0043906]; ATP binding [GO:0005524]; proline-tRNA ligase activity [GO:0004827]; prolyl-tRNA aminoacylation [GO:0006433] Ala-tRNA(Pro) hydrolase activity [GO:0043906]; ATP binding [GO:0005524]; proline-tRNA ligase activity [GO:0004827] GO:0004827; GO:0005524; GO:0005829; GO:0006433; GO:0043906 SUBCELLULAR LOCATION: Cytoplasm. +P0AGL2 TDCF_ECOLI Putative reactive intermediate deaminase TdcF (EC 3.5.4.-) tdcF yhaR b3113 JW5521 yhaR tdcF 14,007 L-threonine catabolic process to propionate [GO:0070689]; organonitrogen compound catabolic process [GO:1901565]; threonine metabolic process [GO:0006566] cytosol [GO:0005829] cytosol [GO:0005829]; deaminase activity [GO:0019239]; identical protein binding [GO:0042802]; L-threonine catabolic process to propionate [GO:0070689]; organonitrogen compound catabolic process [GO:1901565]; threonine metabolic process [GO:0006566] deaminase activity [GO:0019239]; identical protein binding [GO:0042802] GO:0005829; GO:0006566; GO:0019239; GO:0042802; GO:0070689; GO:1901565 +Q2EES9 TORI_ECOLI Response regulator inhibitor for tor operon (Tor inhibitor) torI b4501 JW5387 torI 7,678 DNA excision [GO:0044349]; DNA recombination [GO:0006310]; negative regulation of DNA-templated transcription, initiation [GO:2000143] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565]; DNA excision [GO:0044349]; DNA recombination [GO:0006310]; negative regulation of DNA-templated transcription, initiation [GO:2000143] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565] GO:0003677; GO:0006310; GO:0042802; GO:0043565; GO:0044349; GO:2000143 +P45532 TUSD_ECOLI Sulfurtransferase TusD (EC 2.8.1.-) (tRNA 2-thiouridine synthesizing protein D) tusD yheN b3345 JW3307 yheN tusD 13,641 tRNA wobble position uridine thiolation [GO:0002143] cytosol [GO:0005829]; sulfurtransferase complex [GO:1990228] cytosol [GO:0005829]; sulfurtransferase complex [GO:1990228]; sulfur carrier activity [GO:0097163]; sulfurtransferase activity [GO:0016783]; tRNA wobble position uridine thiolation [GO:0002143] sulfur carrier activity [GO:0097163]; sulfurtransferase activity [GO:0016783] GO:0002143; GO:0005829; GO:0016783; GO:0097163; GO:1990228 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P45463 TTDR_ECOLI HTH-type transcriptional activator TtdR ttdR ygiP b3060 JW3032 ygiP ttdR 35,315 positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0001228; GO:0003700; GO:0006351; GO:0043565; GO:0045893 +P0A9P4 TRXB_ECOLI Thioredoxin reductase (TRXR) (EC 1.8.1.9) trxB b0888 JW0871 trxB 34,623 removal of superoxide radicals [GO:0019430] cytosol [GO:0005829] cytosol [GO:0005829]; flavin adenine dinucleotide binding [GO:0050660]; thioredoxin-disulfide reductase activity [GO:0004791]; removal of superoxide radicals [GO:0019430] flavin adenine dinucleotide binding [GO:0050660]; thioredoxin-disulfide reductase activity [GO:0004791] GO:0004791; GO:0005829; GO:0019430; GO:0050660 SUBCELLULAR LOCATION: Cytoplasm. +P22186 MRAZ_ECOLI Transcriptional regulator MraZ mraZ yabB b0081 JW0079 yabB mraZ 17,386 negative regulation of DNA-templated transcription, initiation [GO:2000143]; negative regulation of transcription, DNA-templated [GO:0045892] cytoplasm [GO:0005737]; nucleoid [GO:0009295] cytoplasm [GO:0005737]; nucleoid [GO:0009295]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of DNA-templated transcription, initiation [GO:2000143]; negative regulation of transcription, DNA-templated [GO:0045892] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0005737; GO:0009295; GO:0043565; GO:0045892; GO:2000143 SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-Rule:MF_01008, ECO:0000269|PubMed:24659771}. +P0A9N4 PFLA_ECOLI Pyruvate formate-lyase 1-activating enzyme (EC 1.97.1.4) (Formate-C-acetyltransferase-activating enzyme 1) (PFL-activating enzyme 1) pflA act b0902 JW0885 act pflA 28,204 cellular response to DNA damage stimulus [GO:0006974]; glucose metabolic process [GO:0006006] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; [formate-C-acetyltransferase]-activating enzyme activity [GO:0043365]; oxidoreductase activity [GO:0016491]; potassium ion binding [GO:0030955]; cellular response to DNA damage stimulus [GO:0006974]; glucose metabolic process [GO:0006006] [formate-C-acetyltransferase]-activating enzyme activity [GO:0043365]; 4 iron, 4 sulfur cluster binding [GO:0051539]; oxidoreductase activity [GO:0016491]; potassium ion binding [GO:0030955] GO:0005829; GO:0006006; GO:0006974; GO:0016491; GO:0030955; GO:0043365; GO:0051539 SUBCELLULAR LOCATION: Cytoplasm. +P0A7T3 RS16_ECOLI 30S ribosomal protein S16 (Small ribosomal subunit protein bS16) rpsP b2609 JW2590 rpsP 9,191 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935] cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935]; endodeoxyribonuclease activity [GO:0004520]; four-way junction DNA binding [GO:0000400]; structural constituent of ribosome [GO:0003735]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] endodeoxyribonuclease activity [GO:0004520]; four-way junction DNA binding [GO:0000400]; structural constituent of ribosome [GO:0003735] GO:0000028; GO:0000400; GO:0003735; GO:0004520; GO:0006412; GO:0015935; GO:0022627 +P60390 RSMH_ECOLI Ribosomal RNA small subunit methyltransferase H (EC 2.1.1.199) (16S rRNA m(4)C1402 methyltransferase) (rRNA (cytosine-N(4)-)-methyltransferase RsmH) rsmH mraW yabC b0082 JW0080 mraW yabC rsmH 34,878 rRNA base methylation [GO:0070475] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; rRNA (cytosine-N4-)-methyltransferase activity [GO:0071424]; rRNA base methylation [GO:0070475] rRNA (cytosine-N4-)-methyltransferase activity [GO:0071424] GO:0005737; GO:0005829; GO:0070475; GO:0071424 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10572301}. +P0AGH3 SAPB_ECOLI Putrescine export system permease protein SapB sapB b1293 JW1286 sapB 36,038 putrescine transport [GO:0015847] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; dipeptide transmembrane transporter activity [GO:0071916]; putrescine transmembrane transporter activity [GO:0015489]; putrescine transport [GO:0015847] dipeptide transmembrane transporter activity [GO:0071916]; putrescine transmembrane transporter activity [GO:0015489] GO:0005886; GO:0015489; GO:0015847; GO:0016021; GO:0071916 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P0AAH4 SAPD_ECOLI Putrescine export system ATP-binding protein SapD sapD trkE b1291 JW1284 trkE sapD 37,661 peptide transport [GO:0015833]; potassium ion transmembrane transport [GO:0071805]; putrescine transport [GO:0015847] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; putrescine transmembrane transporter activity [GO:0015489]; peptide transport [GO:0015833]; potassium ion transmembrane transport [GO:0071805]; putrescine transport [GO:0015847] ATP binding [GO:0005524]; putrescine transmembrane transporter activity [GO:0015489] GO:0005524; GO:0005886; GO:0015489; GO:0015833; GO:0015847; GO:0071805 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P0A8R4 SLYX_ECOLI Protein SlyX slyX b3348 JW3310 slyX 8,214 +P0AGJ2 TRMH_ECOLI tRNA (guanosine(18)-2'-O)-methyltransferase (EC 2.1.1.34) (tRNA [Gm18] methyltransferase) trmH spoU b3651 JW3626 spoU trmH 25,343 tRNA guanine ribose methylation [GO:0002938]; tRNA methylation [GO:0030488] tRNA (guanosine-2'-O-)-methyltransferase activity [GO:0009020]; tRNA (uracil-2'-O-)-methyltransferase activity [GO:0052665]; tRNA binding [GO:0000049]; tRNA guanine ribose methylation [GO:0002938]; tRNA methylation [GO:0030488] tRNA (guanosine-2'-O-)-methyltransferase activity [GO:0009020]; tRNA (uracil-2'-O-)-methyltransferase activity [GO:0052665]; tRNA binding [GO:0000049] GO:0000049; GO:0002938; GO:0009020; GO:0030488; GO:0052665 +P0A910 OMPA_ECOLI Outer membrane protein A (OmpA) (Outer membrane porin A) (Outer membrane protein 3A) (Outer membrane protein B) (Outer membrane protein II*) (Outer membrane protein d) ompA con tolG tut b0957 JW0940 con tolG tut ompA 37,201 cellular response to DNA damage stimulus [GO:0006974]; conjugation [GO:0000746]; detection of virus [GO:0009597]; ion transport [GO:0006811]; viral entry into host cell [GO:0046718] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; outer membrane [GO:0019867]; outer membrane-bounded periplasmic space [GO:0030288]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; outer membrane [GO:0019867]; outer membrane-bounded periplasmic space [GO:0030288]; pore complex [GO:0046930]; identical protein binding [GO:0042802]; ion transmembrane transporter activity [GO:0015075]; porin activity [GO:0015288]; cellular response to DNA damage stimulus [GO:0006974]; conjugation [GO:0000746]; detection of virus [GO:0009597]; ion transport [GO:0006811]; viral entry into host cell [GO:0046718] identical protein binding [GO:0042802]; ion transmembrane transporter activity [GO:0015075]; porin activity [GO:0015288] GO:0000746; GO:0006811; GO:0006974; GO:0009279; GO:0009597; GO:0015075; GO:0015288; GO:0016020; GO:0016021; GO:0019867; GO:0030288; GO:0042802; GO:0045203; GO:0046718; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_00842, ECO:0000269|PubMed:10636850, ECO:0000269|PubMed:10947984, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:21778229, ECO:0000269|PubMed:7813480, ECO:0000269|PubMed:791936, ECO:0000305|PubMed:9808047}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00842, ECO:0000269|PubMed:10764596, ECO:0000269|PubMed:11276254, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:16719475, ECO:0000269|PubMed:21778229, ECO:0000269|PubMed:7813480, ECO:0000269|PubMed:9808047, ECO:0000305|PubMed:10636850}. Note=The 8 beta strands are tilted by about 45 degrees relative to the membrane normal (PubMed:9808047, PubMed:10764596, PubMed:11276254, PubMed:16719475). Evenly distributed on the outer membrane (PubMed:10947984). {ECO:0000269|PubMed:10764596, ECO:0000269|PubMed:10947984, ECO:0000269|PubMed:11276254, ECO:0000269|PubMed:16719475, ECO:0000269|PubMed:9808047}. +P21514 PDEL_ECOLI Cyclic di-GMP phosphodiesterase PdeL (EC 3.1.4.52) pdeL yahA b0315 JW0307 yahA pdeL 40,725 positive regulation of transcription, DNA-templated [GO:0045893] bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding [GO:0000984]; cyclic-guanylate-specific phosphodiesterase activity [GO:0071111]; metal ion binding [GO:0046872]; positive regulation of transcription, DNA-templated [GO:0045893] bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding [GO:0000984]; cyclic-guanylate-specific phosphodiesterase activity [GO:0071111]; metal ion binding [GO:0046872] GO:0000984; GO:0045893; GO:0046872; GO:0071111 +P0AFI9 PERM_ECOLI Putative permease PerM perM yfgO b2493 JW2478 yfgO perM 39,194 transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transport [GO:0055085] GO:0005886; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P07004 PROA_ECOLI Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase) (GSA dehydrogenase) proA b0243 JW0233 proA 44,630 L-proline biosynthetic process [GO:0055129] cytosol [GO:0005829] cytosol [GO:0005829]; glutamate-5-semialdehyde dehydrogenase activity [GO:0004350]; identical protein binding [GO:0042802]; NADP binding [GO:0050661]; L-proline biosynthetic process [GO:0055129] glutamate-5-semialdehyde dehydrogenase activity [GO:0004350]; identical protein binding [GO:0042802]; NADP binding [GO:0050661] GO:0004350; GO:0005829; GO:0042802; GO:0050661; GO:0055129 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00412}. +P21338 RNI_ECOLI Ribonuclease I (RNase I) (EC 4.6.1.21) (Enterobacter ribonuclease) rna rnsA b0611 JW0603 rnsA rna 29,618 RNA catabolic process [GO:0006401] cytoplasm [GO:0005737]; outer membrane-bounded periplasmic space [GO:0030288] cytoplasm [GO:0005737]; outer membrane-bounded periplasmic space [GO:0030288]; Enterobacter ribonuclease activity [GO:0008847]; lyase activity [GO:0016829]; ribonuclease T2 activity [GO:0033897]; RNA binding [GO:0003723]; RNA catabolic process [GO:0006401] Enterobacter ribonuclease activity [GO:0008847]; lyase activity [GO:0016829]; ribonuclease T2 activity [GO:0033897]; RNA binding [GO:0003723] GO:0003723; GO:0005737; GO:0006401; GO:0008847; GO:0016829; GO:0030288; GO:0033897 SUBCELLULAR LOCATION: Periplasm. Cytoplasm. Note=RNase I (periplasmic) and RNase I* (cytoplasmic) appear to be isoforms apparently encoded by the same gene. The cytoplasmic form is less active towards natural polymer RNA. +P77468 SFMD_ECOLI Outer membrane usher protein SfmD sfmD b0532 JW0521 sfmD 95,677 pilus assembly [GO:0009297]; pilus organization [GO:0043711] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; fimbrial usher porin activity [GO:0015473]; pilus assembly [GO:0009297]; pilus organization [GO:0043711] fimbrial usher porin activity [GO:0015473] GO:0009279; GO:0009297; GO:0015473; GO:0016021; GO:0043711 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. +P0ACH1 SFSB_ECOLI Sugar fermentation stimulation protein B (Ner-like protein) sfsB nlp sfs7 b3188 JW3155 nlp sfs7 sfsB 10,495 DNA binding [GO:0003677] DNA binding [GO:0003677] GO:0003677 +P39300 ULAG_ECOLI Probable L-ascorbate-6-phosphate lactonase UlaG (EC 3.1.1.-) (L-ascorbate utilization protein G) ulaG yjfR b4192 JW5868 yjfR ulaG 40,061 L-ascorbic acid catabolic process [GO:0019854] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; L-ascorbate 6-phosphate lactonase activity [GO:0035460]; manganese ion binding [GO:0030145]; L-ascorbic acid catabolic process [GO:0019854] L-ascorbate 6-phosphate lactonase activity [GO:0035460]; manganese ion binding [GO:0030145] GO:0005737; GO:0019854; GO:0030145; GO:0035460 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P76373 UDG_ECOLI UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) ugd pmrE udg yefA b2028 JW2010 pmrE udg yefA ugd 43,657 colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103]; UDP-glucuronate biosynthetic process [GO:0006065] NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979]; colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103]; UDP-glucuronate biosynthetic process [GO:0006065] NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979] GO:0003979; GO:0006065; GO:0009103; GO:0009242; GO:0051287 +P07024 USHA_ECOLI Protein UshA [Includes: UDP-sugar hydrolase (EC 3.6.1.45) (UDP-sugar diphosphatase) (UDP-sugar pyrophosphatase); 5'-nucleotidase (5'-NT) (EC 3.1.3.5)] ushA b0480 JW0469 ushA 60,824 nucleotide catabolic process [GO:0009166] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; UDP-sugar diphosphatase activity [GO:0008768]; nucleotide catabolic process [GO:0009166] 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; UDP-sugar diphosphatase activity [GO:0008768] GO:0000166; GO:0008253; GO:0008768; GO:0009166; GO:0030288; GO:0046872 SUBCELLULAR LOCATION: Periplasm. Note=Exported from the cell, except a small proportion that is internally localized. +P0ACI3 XYLR_ECOLI Xylose operon regulatory protein xylR b3569 JW3541 xylR 44,869 regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355 +P0A8Z3 YBGC_ECOLI Acyl-CoA thioester hydrolase YbgC (Acyl-CoA thioesterase) (EC 3.1.2.-) ybgC b0736 JW0726 ybgC 15,562 lipid metabolic process [GO:0006629] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; acyl-CoA hydrolase activity [GO:0047617]; thiolester hydrolase activity [GO:0016790]; lipid metabolic process [GO:0006629] acyl-CoA hydrolase activity [GO:0047617]; thiolester hydrolase activity [GO:0016790] GO:0005886; GO:0006629; GO:0016790; GO:0047617 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16294310}; Peripheral membrane protein {ECO:0000269|PubMed:16294310}; Cytoplasmic side {ECO:0000269|PubMed:16294310}. +P75811 RCDA_ECOLI HTH-type transcriptional regulator RcdA (Regulator of csgD) rcdA ybjK b0846 JW5114 ybjK rcdA 20,307 positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006351; GO:0045893 +P64554 QUEE_ECOLI 7-carboxy-7-deazaguanine synthase (CDG synthase) (EC 4.3.99.3) (Queuosine biosynthesis protein QueE) queE ygcF b2777 JW2748 ygcF queE 25,030 negative regulation of cytokinesis [GO:0032466]; queuosine biosynthetic process [GO:0008616] cell division site [GO:0032153]; cytosol [GO:0005829] cell division site [GO:0032153]; cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; carbon-nitrogen lyase activity [GO:0016840]; magnesium ion binding [GO:0000287]; S-adenosyl-L-methionine binding [GO:1904047]; negative regulation of cytokinesis [GO:0032466]; queuosine biosynthetic process [GO:0008616] 4 iron, 4 sulfur cluster binding [GO:0051539]; carbon-nitrogen lyase activity [GO:0016840]; magnesium ion binding [GO:0000287]; S-adenosyl-L-methionine binding [GO:1904047] GO:0000287; GO:0005829; GO:0008616; GO:0016840; GO:0032153; GO:0032466; GO:0051539; GO:1904047 +P25742 RFAQ_ECOLI Lipopolysaccharide core heptosyltransferase RfaQ (EC 2.-.-.-) rfaQ waaQ b3632 JW3607 waaQ rfaQ 38,731 lipopolysaccharide core region biosynthetic process [GO:0009244] cytosol [GO:0005829] cytosol [GO:0005829]; ADP-heptose-lipopolysaccharide heptosyltransferase activity [GO:0008713]; lipopolysaccharide core heptosyltransferase activity [GO:0071967]; lipopolysaccharide core region biosynthetic process [GO:0009244] ADP-heptose-lipopolysaccharide heptosyltransferase activity [GO:0008713]; lipopolysaccharide core heptosyltransferase activity [GO:0071967] GO:0005829; GO:0008713; GO:0009244; GO:0071967 +P68919 RL25_ECOLI 50S ribosomal protein L25 (Large ribosomal subunit protein bL25) rplY b2185 JW2173 rplY 10,693 negative regulation of translation [GO:0017148]; response to radiation [GO:0009314]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; 5S rRNA binding [GO:0008097]; structural constituent of ribosome [GO:0003735]; negative regulation of translation [GO:0017148]; response to radiation [GO:0009314]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] 5S rRNA binding [GO:0008097]; structural constituent of ribosome [GO:0003735] GO:0000027; GO:0003735; GO:0005829; GO:0006412; GO:0008097; GO:0009314; GO:0017148; GO:0022625 +P55135 RLMD_ECOLI 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD (EC 2.1.1.190) (23S rRNA(m5U1939)-methyltransferase) rlmD rumA ygcA b2785 JW2756 rumA ygcA rlmD 48,052 rRNA base methylation [GO:0070475] 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; RNA binding [GO:0003723]; rRNA (uridine-C5-)-methyltransferase activity [GO:0070041]; rRNA base methylation [GO:0070475] 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; RNA binding [GO:0003723]; rRNA (uridine-C5-)-methyltransferase activity [GO:0070041] GO:0003723; GO:0005506; GO:0051539; GO:0070041; GO:0070475 +Q46802 UACR_ECOLI Putative uric acid sigma-54-dependent transcriptional regulator UacR (Uric acid regulator) uacR ygeV b2869 JW2837 ygeV uacR 66,096 regulation of transcription, DNA-templated [GO:0006355]; urate catabolic process [GO:0019628] ATP binding [GO:0005524]; sequence-specific DNA binding [GO:0043565]; transcription factor binding [GO:0008134]; regulation of transcription, DNA-templated [GO:0006355]; urate catabolic process [GO:0019628] ATP binding [GO:0005524]; sequence-specific DNA binding [GO:0043565]; transcription factor binding [GO:0008134] GO:0005524; GO:0006355; GO:0008134; GO:0019628; GO:0043565 +P09184 VSR_ECOLI Very short patch repair protein (EC 3.1.-.-) (DNA mismatch endonuclease) (V.EcoKDcm) (Vsr mismatch endonuclease) vsr b1960 JW1943 vsr 18,016 mismatch repair [GO:0006298] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; T/G mismatch-specific endonuclease activity [GO:0043765]; mismatch repair [GO:0006298] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; T/G mismatch-specific endonuclease activity [GO:0043765] GO:0003677; GO:0006298; GO:0043765; GO:0046872 +P0AAA7 WZXE_ECOLI Lipid III flippase wzxE wzx yifJ b3792 JW3766 wzx yifJ wzxE 44,960 enterobacterial common antigen biosynthetic process [GO:0009246] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; enterobacterial common antigen biosynthetic process [GO:0009246] GO:0005886; GO:0005887; GO:0009246 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02024, ECO:0000305}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02024}. +P32057 WCAI_ECOLI Putative colanic acid biosynthesis glycosyl transferase WcaI wcaI yefD b2050 JW2035 yefD wcaI 44,914 colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] alpha-(1->3)-fucosyltransferase activity [GO:0046920]; colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] alpha-(1->3)-fucosyltransferase activity [GO:0046920] GO:0009103; GO:0009242; GO:0045228; GO:0046920 +P12994 YBHB_ECOLI UPF0098 protein YbhB ybhB b0773 JW0756 ybhB 17,085 cytoplasm [GO:0005737] cytoplasm [GO:0005737] GO:0005737 SUBCELLULAR LOCATION: Cytoplasm. +P75809 YBJI_ECOLI 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YbjI (EC 3.1.3.104) ybjI b0844 JW5113 ybjI 30,196 riboflavin biosynthetic process [GO:0009231] cytosol [GO:0005829] cytosol [GO:0005829]; 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity [GO:0043726]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; riboflavin biosynthetic process [GO:0009231] 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity [GO:0043726]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791] GO:0000287; GO:0005829; GO:0009231; GO:0016791; GO:0043726 +P0AAZ0 YBJO_ECOLI Inner membrane protein YbjO ybjO b0858 JW0842 ybjO 18,518 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P75683 YAGG_ECOLI Putative glycoside/cation symporter YagG yagG b0270 JW0263 yagG 50,632 carbohydrate transport [GO:0008643]; organic substance transport [GO:0071702]; sodium ion transport [GO:0006814] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; symporter activity [GO:0015293]; carbohydrate transport [GO:0008643]; organic substance transport [GO:0071702]; sodium ion transport [GO:0006814] symporter activity [GO:0015293] GO:0005886; GO:0005887; GO:0006814; GO:0008643; GO:0015293; GO:0071702 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +Q47149 YAFQ_ECOLI mRNA interferase toxin YafQ (EC 3.1.-.-) (Endoribonuclease YafQ) (Toxin YafQ) yafQ b0225 JW0215 yafQ 10,847 mRNA catabolic process [GO:0006402]; response to antibiotic [GO:0046677]; single-species biofilm formation [GO:0044010]; translational termination [GO:0006415] DNA binding [GO:0003677]; endoribonuclease activity [GO:0004521]; endoribonuclease activity, producing 3'-phosphomonoesters [GO:0016892]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; mRNA catabolic process [GO:0006402]; response to antibiotic [GO:0046677]; single-species biofilm formation [GO:0044010]; translational termination [GO:0006415] DNA binding [GO:0003677]; endoribonuclease activity [GO:0004521]; endoribonuclease activity, producing 3'-phosphomonoesters [GO:0016892]; ribosome binding [GO:0043022]; RNA binding [GO:0003723] GO:0003677; GO:0003723; GO:0004521; GO:0006402; GO:0006415; GO:0016892; GO:0043022; GO:0044010; GO:0046677 +P0A8E5 YACL_ECOLI UPF0231 protein YacL yacL b0119 JW0115 yacL 13,942 +P0AAR8 YBAV_ECOLI Uncharacterized protein YbaV ybaV b0442 JW0432 ybaV 12,704 DNA repair [GO:0006281] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; DNA binding [GO:0003677]; DNA repair [GO:0006281] DNA binding [GO:0003677] GO:0003677; GO:0006281; GO:0030288 +P0AAS9 YBDD_ECOLI Uncharacterized protein YbdD ybdD b4512 JW0591 ybdD 7,467 +P0DPM7 YADW_ECOLI Protein YadW yadW b4728 yadW 2,330 +P18393 YBDZ_ECOLI Enterobactin biosynthesis protein YbdZ ybdZ b4511 JW0577 ybdZ 8,271 enterobactin biosynthetic process [GO:0009239]; positive regulation of catalytic activity [GO:0043085]; siderophore biosynthetic process [GO:0019290] cytosol [GO:0005829] cytosol [GO:0005829]; enterobactin biosynthetic process [GO:0009239]; positive regulation of catalytic activity [GO:0043085]; siderophore biosynthetic process [GO:0019290] GO:0005829; GO:0009239; GO:0019290; GO:0043085 +P77526 YFCG_ECOLI Disulfide-bond oxidoreductase YfcG (EC 1.8.4.-) (GSH-dependent disulfide-bond oxidoreductase YfcG) (GST N1-1) (GST-like protein YfcG) (Organic hydroperoxidase) (EC 1.11.1.-) yfcG b2302 JW2299 yfcG 24,516 glutathione metabolic process [GO:0006749]; response to oxidative stress [GO:0006979] disulfide oxidoreductase activity [GO:0015036]; peroxidase activity [GO:0004601]; glutathione metabolic process [GO:0006749]; response to oxidative stress [GO:0006979] disulfide oxidoreductase activity [GO:0015036]; peroxidase activity [GO:0004601] GO:0004601; GO:0006749; GO:0006979; GO:0015036 +P0AAS0 YLAC_ECOLI Inner membrane protein YlaC ylaC b0458 JW5063 ylaC 18,267 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76536 YFEX_ECOLI Dye-decolorizing peroxidase YfeX (EC 1.11.1.-) (Porphyrinogen oxidase) yfeX b2431 JW2424 yfeX 33,052 cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] heme binding [GO:0020037]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] GO:0004601; GO:0005737; GO:0005829; GO:0020037; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19564607}. +P0ADA3 NLPD_ECOLI Murein hydrolase activator NlpD nlpD b2742 JW2712 nlpD 40,149 cell cycle [GO:0007049]; positive regulation of hydrolase activity [GO:0051345]; response to drug [GO:0042493]; septum digestion after cytokinesis [GO:0000920] cell division site [GO:0032153]; cell outer membrane [GO:0009279]; plasma membrane [GO:0005886] cell division site [GO:0032153]; cell outer membrane [GO:0009279]; plasma membrane [GO:0005886]; metalloendopeptidase activity [GO:0004222]; cell cycle [GO:0007049]; positive regulation of hydrolase activity [GO:0051345]; response to drug [GO:0042493]; septum digestion after cytokinesis [GO:0000920] metalloendopeptidase activity [GO:0004222] GO:0000920; GO:0004222; GO:0005886; GO:0007049; GO:0009279; GO:0032153; GO:0042493; GO:0051345 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. Note=Localizes at the septal ring. {ECO:0000269|PubMed:19525345}. +P76242 NIMT_ECOLI 2-nitroimidazole transporter nimT yeaN b1791 JW1780 yeaN nimT 41,208 response to antibiotic [GO:0046677] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; response to antibiotic [GO:0046677] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0022857; GO:0046677 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P0A729 NTPPB_ECOLI 7-methyl-GTP pyrophosphatase (m(7)GTP pyrophosphatase) (EC 3.6.1.-) yceF b1087 JW5155 yceF 21,691 nucleotide metabolic process [GO:0009117] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; nucleoside-triphosphate diphosphatase activity [GO:0047429]; nucleotide metabolic process [GO:0009117] nucleoside-triphosphate diphosphatase activity [GO:0047429] GO:0005737; GO:0009117; GO:0047429 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00528, ECO:0000305}. +P27298 OPDA_ECOLI Oligopeptidase A (EC 3.4.24.70) prlC opdA b3498 JW3465 opdA prlC 77,167 DNA replication [GO:0006260]; peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]; signal peptide processing [GO:0006465] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; DNA replication [GO:0006260]; peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]; signal peptide processing [GO:0006465] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233] GO:0004222; GO:0005737; GO:0005829; GO:0006260; GO:0006465; GO:0006508; GO:0006518; GO:0008233; GO:0046872 +P00452 RIR1_ECOLI Ribonucleoside-diphosphate reductase 1 subunit alpha (EC 1.17.4.1) (Protein B1) (Ribonucleoside-diphosphate reductase 1 R1 subunit) (Ribonucleotide reductase 1) nrdA dnaF b2234 JW2228 dnaF nrdA 85,775 deoxyribonucleotide biosynthetic process [GO:0009263]; DNA replication [GO:0006260]; nucleobase-containing small molecule interconversion [GO:0015949] cytosol [GO:0005829]; ribonucleoside-diphosphate reductase complex [GO:0005971] cytosol [GO:0005829]; ribonucleoside-diphosphate reductase complex [GO:0005971]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA replication [GO:0006260]; nucleobase-containing small molecule interconversion [GO:0015949] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748] GO:0004748; GO:0005524; GO:0005829; GO:0005971; GO:0006260; GO:0009263; GO:0015949; GO:0042802 +P27243 RFAL_ECOLI O-antigen ligase rfaL waaL b3622 JW3597 waaL rfaL 46,878 lipopolysaccharide core region biosynthetic process [GO:0009244] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ligase activity [GO:0016874]; transferase activity, transferring glycosyl groups [GO:0016757]; lipopolysaccharide core region biosynthetic process [GO:0009244] ligase activity [GO:0016874]; transferase activity, transferring glycosyl groups [GO:0016757] GO:0005886; GO:0005887; GO:0009244; GO:0016757; GO:0016874 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P0A7L8 RL27_ECOLI 50S ribosomal protein L27 (Large ribosomal subunit protein bL27) rpmA b3185 JW3152 rpmA 9,124 assembly of large subunit precursor of preribosome [GO:1902626]; mature ribosome assembly [GO:0042256]; positive regulation of ribosome biogenesis [GO:0090070]; regulation of cell growth [GO:0001558]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] cytosolic large ribosomal subunit [GO:0022625]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049]; assembly of large subunit precursor of preribosome [GO:1902626]; mature ribosome assembly [GO:0042256]; positive regulation of ribosome biogenesis [GO:0090070]; regulation of cell growth [GO:0001558]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] ribosome binding [GO:0043022]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049] GO:0000027; GO:0000049; GO:0001558; GO:0003735; GO:0006412; GO:0019843; GO:0022625; GO:0042256; GO:0043022; GO:0090070; GO:1902626 +P67087 RSMI_ECOLI Ribosomal RNA small subunit methyltransferase I (EC 2.1.1.198) (16S rRNA 2'-O-ribose C1402 methyltransferase) (rRNA (cytidine-2'-O-)-methyltransferase RsmI) rsmI yraL b3146 JW3115 yraL rsmI 31,348 enzyme-directed rRNA 2'-O-methylation [GO:0000453] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; rRNA (cytosine-2'-O-)-methyltransferase activity [GO:0070677]; enzyme-directed rRNA 2'-O-methylation [GO:0000453] rRNA (cytosine-2'-O-)-methyltransferase activity [GO:0070677] GO:0000453; GO:0005737; GO:0070677 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AGH5 SAPC_ECOLI Putrescine export system permease protein SapC sapC b1292 JW1285 sapC 31,548 putrescine transport [GO:0015847] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; putrescine transmembrane transporter activity [GO:0015489]; putrescine transport [GO:0015847] putrescine transmembrane transporter activity [GO:0015489] GO:0005886; GO:0015489; GO:0015847; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P31436 SETC_ECOLI Sugar efflux transporter C setC yicK b3659 JW3633 yicK setC 43,493 cellular response to glucose-phosphate stress [GO:0036448]; glucose transmembrane transport [GO:1904659]; lactose transport [GO:0015767]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; carbohydrate:proton symporter activity [GO:0005351]; cellular response to glucose-phosphate stress [GO:0036448]; glucose transmembrane transport [GO:1904659]; lactose transport [GO:0015767]; transmembrane transport [GO:0055085] carbohydrate:proton symporter activity [GO:0005351] GO:0005351; GO:0005886; GO:0015767; GO:0016021; GO:0036448; GO:0055085; GO:1904659 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AFE8 NUOM_ECOLI NADH-quinone oxidoreductase subunit M (EC 7.1.1.-) (NADH dehydrogenase I subunit M) (NDH-1 subunit M) (NUO13) nuoM b2277 JW2272 nuoM 56,525 aerobic respiration [GO:0009060]; ATP synthesis coupled electron transport [GO:0042773]; electron transport coupled proton transport [GO:0015990] integral component of plasma membrane [GO:0005887]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272] integral component of plasma membrane [GO:0005887]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; ubiquinone binding [GO:0048039]; aerobic respiration [GO:0009060]; ATP synthesis coupled electron transport [GO:0042773]; electron transport coupled proton transport [GO:0015990] NADH dehydrogenase (ubiquinone) activity [GO:0008137]; ubiquinone binding [GO:0048039] GO:0005886; GO:0005887; GO:0008137; GO:0009060; GO:0015990; GO:0030964; GO:0042773; GO:0045272; GO:0048039 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A921 PA1_ECOLI Phospholipase A1 (EC 3.1.1.32) (EC 3.1.1.4) (Detergent-resistant phospholipase A) (DR-phospholipase A) (Outer membrane phospholipase A) (OM PLA) (OMPLA) (Phosphatidylcholine 1-acylhydrolase) pldA b3821 JW3794 pldA 33,163 lipid catabolic process [GO:0016042]; phosphatidylglycerol metabolic process [GO:0046471] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; intrinsic component of cell outer membrane [GO:0031230] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; intrinsic component of cell outer membrane [GO:0031230]; 1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; calcium ion binding [GO:0005509]; lysophospholipase activity [GO:0004622]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) [GO:0102567]; phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) [GO:0102568]; phospholipase activity [GO:0004620]; protein homodimerization activity [GO:0042803]; lipid catabolic process [GO:0016042]; phosphatidylglycerol metabolic process [GO:0046471] 1-acyl-2-lysophosphatidylserine acylhydrolase activity [GO:0052740]; calcium ion binding [GO:0005509]; lysophospholipase activity [GO:0004622]; phosphatidylserine 1-acylhydrolase activity [GO:0052739]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) [GO:0102567]; phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) [GO:0102568]; phospholipase activity [GO:0004620]; protein homodimerization activity [GO:0042803] GO:0004620; GO:0004622; GO:0004623; GO:0005509; GO:0008970; GO:0009279; GO:0016042; GO:0031230; GO:0042803; GO:0045203; GO:0046471; GO:0052739; GO:0052740; GO:0102567; GO:0102568 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:6397463}; Multi-pass membrane protein {ECO:0000269|PubMed:6397463}. Note=One of the very few enzymes located there. +P32670 PTFX2_ECOLI Multiphosphoryl transfer protein 2 (MTP 2) (Triphosphoryl transfer protein 2) (TTP 2) [Includes: Phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) (Enzyme I-Ani) (Phosphotransferase system enzyme I); Phosphocarrier protein HPr (Protein H); PTS system fructose-like EIIA component (EC 2.7.1.202) (Fructose-like phosphotransferase enzyme IIA component)] ptsA frwA yijH b3947 JW5555 frwA yijH ptsA 91,774 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphoenolpyruvate-protein phosphotransferase activity [GO:0008965]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphoenolpyruvate-protein phosphotransferase activity [GO:0008965] GO:0005737; GO:0008965; GO:0009401; GO:0016301; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P69797 PTNAB_ECOLI PTS system mannose-specific EIIAB component (EC 2.7.1.191) (EIIAB-Man) (EIII-Man) [Includes: Mannose-specific phosphotransferase enzyme IIA component (PTS system mannose-specific EIIA component); Mannose-specific phosphotransferase enzyme IIB component (PTS system mannose-specific EIIB component)] manX gptB ptsL b1817 JW1806 gptB ptsL manX 35,048 glucose import across plasma membrane [GO:0098708]; mannose transmembrane transport [GO:0015761]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737]; cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020] cytoplasm [GO:0005737]; cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity [GO:0022870]; glucose import across plasma membrane [GO:0098708]; mannose transmembrane transport [GO:0015761]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity [GO:0022870] GO:0005737; GO:0005829; GO:0005887; GO:0009401; GO:0015761; GO:0016020; GO:0016301; GO:0022870; GO:0098708 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:2951378, ECO:0000269|PubMed:2999119}. Cell inner membrane {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:2999119}; Peripheral membrane protein {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:2999119}. +P0DSG0 PSSL_ECOLI Protein PssL pssL b4782 pssL 1,604 +P0AA53 QMCA_ECOLI Protein QmcA qmcA ybbK b0489 JW0478 ybbK qmcA 33,743 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802] identical protein binding [GO:0042802] GO:0005886; GO:0016021; GO:0042802 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16573693}; Single-pass type I membrane protein {ECO:0000269|PubMed:16573693}. +P07010 REM_ECOLI Uncharacterized protein Rem rem b1561 JW1553 rem 9,235 +P0AA10 RL13_ECOLI 50S ribosomal protein L13 (Large ribosomal subunit protein uL13) rplM b3231 JW3200 rplM 16,019 negative regulation of translation [GO:0017148]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; ribosome [GO:0005840] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; ribosome [GO:0005840]; large ribosomal subunit rRNA binding [GO:0070180]; mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735]; zinc ion binding [GO:0008270]; negative regulation of translation [GO:0017148]; translation [GO:0006412] large ribosomal subunit rRNA binding [GO:0070180]; mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735]; zinc ion binding [GO:0008270] GO:0003729; GO:0003735; GO:0005829; GO:0005840; GO:0006412; GO:0008270; GO:0017148; GO:0022625; GO:0070180 +P33227 STFE_ECOLI Putative uncharacterized protein StfE (Side tail fiber protein homolog from lambdoid prophage e14) stfE b1157 JW5172 stfE 19,284 +P52108 RSTA_ECOLI Transcriptional regulatory protein RstA rstA urpT b1608 JW1600 urpT rstA 26,704 cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000976; GO:0001216; GO:0005829; GO:0032993 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P77649 SELO_ECOLI Protein adenylyltransferase SelO (EC 2.7.7.-) (EC 2.7.7.n1) (Selenoprotein O homolog) (SelO) selO ydiU b1706 JW1696 ydiU selO 54,382 protein adenylylation [GO:0018117] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein adenylyltransferase activity [GO:0070733]; protein adenylylation [GO:0018117] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein adenylyltransferase activity [GO:0070733] GO:0000287; GO:0005524; GO:0018117; GO:0070733 +P0A761 NANE_ECOLI Putative N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9) (ManNAc-6-P epimerase) nanE yhcJ b3223 JW3192 yhcJ nanE 24,074 carbohydrate metabolic process [GO:0005975]; N-acetylmannosamine catabolic process [GO:0006053]; N-acetylneuraminate catabolic process [GO:0019262] cytosol [GO:0005829] cytosol [GO:0005829]; N-acylglucosamine-6-phosphate 2-epimerase activity [GO:0047465]; N-acylmannosamine-6-phosphate 2-epimerase activity [GO:0009385]; carbohydrate metabolic process [GO:0005975]; N-acetylmannosamine catabolic process [GO:0006053]; N-acetylneuraminate catabolic process [GO:0019262] N-acylglucosamine-6-phosphate 2-epimerase activity [GO:0047465]; N-acylmannosamine-6-phosphate 2-epimerase activity [GO:0009385] GO:0005829; GO:0005975; GO:0006053; GO:0009385; GO:0019262; GO:0047465 +P0A6Z6 NIKR_ECOLI Nickel-responsive regulator nikR yhhG b3481 JW3446 yhhG nikR 15,094 negative regulation of DNA-templated transcription, initiation [GO:2000143]; regulation of transcription, DNA-templated [GO:0006355]; response to nickel cation [GO:0010045] protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667] protein-DNA complex [GO:0032993]; transcription regulator complex [GO:0005667]; bacterial-type RNA polymerase core promoter sequence-specific DNA binding [GO:0000985]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; nickel cation binding [GO:0016151]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of DNA-templated transcription, initiation [GO:2000143]; regulation of transcription, DNA-templated [GO:0006355]; response to nickel cation [GO:0010045] bacterial-type RNA polymerase core promoter sequence-specific DNA binding [GO:0000985]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; nickel cation binding [GO:0016151]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0000985; GO:0001217; GO:0003677; GO:0005667; GO:0006355; GO:0010045; GO:0016151; GO:0032993; GO:0042802; GO:0043565; GO:2000143 +P25536 NTPPA_ECOLI dTTP/UTP pyrophosphatase (dTTPase/UTPase) (EC 3.6.1.9) (Nucleoside triphosphate pyrophosphatase) (Nucleotide pyrophosphatase) (Nucleotide PPase) yhdE b3248 JW3217 yhdE 21,515 nucleotide metabolic process [GO:0009117] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; dTTP diphosphatase activity [GO:0036218]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; NADH pyrophosphatase activity [GO:0035529]; nucleoside-triphosphate diphosphatase activity [GO:0047429]; UTP diphosphatase activity [GO:0036221]; nucleotide metabolic process [GO:0009117] dTTP diphosphatase activity [GO:0036218]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; NADH pyrophosphatase activity [GO:0035529]; nucleoside-triphosphate diphosphatase activity [GO:0047429]; UTP diphosphatase activity [GO:0036221] GO:0005737; GO:0009117; GO:0030145; GO:0035529; GO:0036218; GO:0036221; GO:0042802; GO:0047429 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00528, ECO:0000305}. +P75800 PDEI_ECOLI Probable cyclic di-GMP phosphodiesterase PdeI (EC 3.1.4.52) pdeI yliE b0833 JW0817 yliE pdeI 90,049 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cyclic-guanylate-specific phosphodiesterase activity [GO:0071111] cyclic-guanylate-specific phosphodiesterase activity [GO:0071111] GO:0005886; GO:0016021; GO:0071111 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P00903 PABA_ECOLI Aminodeoxychorismate synthase component 2 (ADC synthase) (ADCS) (EC 2.6.1.85) (4-amino-4-deoxychorismate synthase component 2) (Aminodeoxychorismate synthase, glutamine amidotransferase component) pabA b3360 JW3323 pabA 20,772 folic acid biosynthetic process [GO:0046656]; glutamine metabolic process [GO:0006541]; tetrahydrofolate biosynthetic process [GO:0046654]; tryptophan biosynthetic process [GO:0000162] 4-amino-4-deoxychorismate synthase activity [GO:0046820]; folic acid biosynthetic process [GO:0046656]; glutamine metabolic process [GO:0006541]; tetrahydrofolate biosynthetic process [GO:0046654]; tryptophan biosynthetic process [GO:0000162] 4-amino-4-deoxychorismate synthase activity [GO:0046820] GO:0000162; GO:0006541; GO:0046654; GO:0046656; GO:0046820 +P0A7M6 RL29_ECOLI 50S ribosomal protein L29 (Large ribosomal subunit protein uL29) rpmC b3312 JW3274 rpmC 7,273 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] cytosolic large ribosomal subunit [GO:0022625]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GO:0000027; GO:0003735; GO:0006412; GO:0019843; GO:0022625 +P21513 RNE_ECOLI Ribonuclease E (RNase E) (EC 3.1.26.12) rne ams hmp1 b1084 JW1071 ams hmp1 rne 118,197 mRNA catabolic process [GO:0006402]; protein homotetramerization [GO:0051289]; regulation of RNA helicase activity [GO:1902280]; RNA catabolic process [GO:0006401]; rRNA 5'-end processing [GO:0000967]; rRNA processing [GO:0006364]; tRNA processing [GO:0008033] bacterial degradosome [GO:1990061]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898] bacterial degradosome [GO:1990061]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; 7S RNA binding [GO:0008312]; DEAD/H-box RNA helicase binding [GO:0017151]; endoribonuclease activity [GO:0004521]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; ribonuclease activity [GO:0004540]; ribonuclease E activity [GO:0008995]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]; mRNA catabolic process [GO:0006402]; protein homotetramerization [GO:0051289]; regulation of RNA helicase activity [GO:1902280]; RNA catabolic process [GO:0006401]; rRNA 5'-end processing [GO:0000967]; rRNA processing [GO:0006364]; tRNA processing [GO:0008033] 7S RNA binding [GO:0008312]; DEAD/H-box RNA helicase binding [GO:0017151]; endoribonuclease activity [GO:0004521]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; ribonuclease activity [GO:0004540]; ribonuclease E activity [GO:0008995]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] GO:0000049; GO:0000287; GO:0000967; GO:0003723; GO:0004521; GO:0004540; GO:0005737; GO:0006364; GO:0006401; GO:0006402; GO:0008033; GO:0008270; GO:0008312; GO:0008995; GO:0009898; GO:0017151; GO:0019843; GO:0042802; GO:0051289; GO:1902280; GO:1990061 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11134527}. Cell inner membrane {ECO:0000269|PubMed:11134527, ECO:0000269|PubMed:22509045}; Peripheral membrane protein {ECO:0000269|PubMed:11134527, ECO:0000269|PubMed:22509045}; Cytoplasmic side {ECO:0000269|PubMed:11134527, ECO:0000269|PubMed:22509045}. Note=Associated with the cytoplasmic membrane via the N- and C-terminal regions. {ECO:0000269|PubMed:11134527, ECO:0000269|PubMed:22509045}. +P62399 RL5_ECOLI 50S ribosomal protein L5 (Large ribosomal subunit protein uL5) rplE b3308 JW3270 rplE 20,302 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; 5S rRNA binding [GO:0008097]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] 5S rRNA binding [GO:0008097]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049] GO:0000027; GO:0000049; GO:0003723; GO:0003735; GO:0005829; GO:0006412; GO:0008097; GO:0022625 +P0AG07 RPE_ECOLI Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (Pentose-5-phosphate 3-epimerase) (PPE) (R5P3E) rpe dod yhfD b3386 JW3349 dod yhfD rpe 24,554 cellular carbohydrate metabolic process [GO:0044262]; pentose catabolic process [GO:0019323]; pentose-phosphate shunt, non-oxidative branch [GO:0009052] cytosol [GO:0005829] cytosol [GO:0005829]; ferrous iron binding [GO:0008198]; metal ion binding [GO:0046872]; ribulose-phosphate 3-epimerase activity [GO:0004750]; cellular carbohydrate metabolic process [GO:0044262]; pentose catabolic process [GO:0019323]; pentose-phosphate shunt, non-oxidative branch [GO:0009052] ferrous iron binding [GO:0008198]; metal ion binding [GO:0046872]; ribulose-phosphate 3-epimerase activity [GO:0004750] GO:0004750; GO:0005829; GO:0008198; GO:0009052; GO:0019323; GO:0044262; GO:0046872 +P0AG63 RS17_ECOLI 30S ribosomal protein S17 (Small ribosomal subunit protein uS17) rpsQ neaA b3311 JW3273 neaA rpsQ 9,704 response to antibiotic [GO:0046677]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627] cytosolic small ribosomal subunit [GO:0022627]; rRNA binding [GO:0019843]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]; response to antibiotic [GO:0046677]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] rRNA binding [GO:0019843]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735] GO:0000028; GO:0003735; GO:0006412; GO:0019843; GO:0022627; GO:0046677; GO:0070181 +P16456 SELD_ECOLI Selenide, water dikinase (EC 2.7.9.3) (Selenium donor protein) (Selenophosphate synthase) selD fdhB b1764 JW1753 fdhB selD 36,687 selenocysteine biosynthetic process [GO:0016260]; tRNA seleno-modification [GO:0070329] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; selenide, water dikinase activity [GO:0004756]; selenocysteine biosynthetic process [GO:0016260]; tRNA seleno-modification [GO:0070329] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; selenide, water dikinase activity [GO:0004756] GO:0000287; GO:0004756; GO:0005524; GO:0005737; GO:0005829; GO:0016260; GO:0042802; GO:0070329 +P0A6W5 GREA_ECOLI Transcription elongation factor GreA (Transcript cleavage factor GreA) greA b3181 JW3148 greA 17,641 DNA-templated transcription, elongation [GO:0006354]; regulation of DNA-templated transcription, elongation [GO:0032784] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; bacterial-type RNA polymerase holo enzyme binding [GO:0001108]; DNA binding [GO:0003677]; RNA polymerase binding [GO:0070063]; DNA-templated transcription, elongation [GO:0006354]; regulation of DNA-templated transcription, elongation [GO:0032784] bacterial-type RNA polymerase holo enzyme binding [GO:0001108]; DNA binding [GO:0003677]; RNA polymerase binding [GO:0070063] GO:0001108; GO:0003677; GO:0005737; GO:0005829; GO:0006354; GO:0032784; GO:0070063 +P52062 HEMW_ECOLI Heme chaperone HemW hemW yggW b2955 JW2922 yggW hemW 42,584 porphyrin-containing compound biosynthetic process [GO:0006779] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 4 iron, 4 sulfur cluster binding [GO:0051539]; coproporphyrinogen oxidase activity [GO:0004109]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; porphyrin-containing compound biosynthetic process [GO:0006779] 4 iron, 4 sulfur cluster binding [GO:0051539]; coproporphyrinogen oxidase activity [GO:0004109]; heme binding [GO:0020037]; metal ion binding [GO:0046872] GO:0004109; GO:0005737; GO:0006779; GO:0020037; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:29282292}. +P39401 OPGB_ECOLI Phosphoglycerol transferase I (EC 2.7.8.20) (Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase) mdoB opgB yjjO b4359 JW5794 opgB yjjO mdoB 85,494 glucan biosynthetic process [GO:0009250]; oligosaccharide-lipid intermediate biosynthetic process [GO:0006490] integral component of membrane [GO:0016021]; membrane [GO:0016020]; periplasmic space [GO:0042597]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; periplasmic space [GO:0042597]; plasma membrane [GO:0005886]; arylsulfatase activity [GO:0004065]; phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity [GO:0008960]; glucan biosynthetic process [GO:0009250]; oligosaccharide-lipid intermediate biosynthetic process [GO:0006490] arylsulfatase activity [GO:0004065]; phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity [GO:0008960] GO:0004065; GO:0005886; GO:0006490; GO:0008960; GO:0009250; GO:0016020; GO:0016021; GO:0042597 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P37057 OGRK_ECOLI Prophage late control protein OgrK (Prophage P2 OGR protein) ogrK b2082 JW2067 ogrK 8,430 +P02931 OMPF_ECOLI Outer membrane porin F (Outer membrane protein 1A) (Outer membrane protein B) (Outer membrane protein F) (Outer membrane protein IA) (Porin OmpF) ompF cmlB coa cry tolF b0929 JW0912 cmlB coa cry tolF ompF 39,333 ion transmembrane transport [GO:0034220]; protein homotrimerization [GO:0070207] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; ion channel complex [GO:0034702]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; ion channel complex [GO:0034702]; pore complex [GO:0046930]; colicin transmembrane transporter activity [GO:0042912]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; ion channel activity [GO:0005216]; ion transmembrane transporter activity [GO:0015075]; lipid binding [GO:0008289]; lipopolysaccharide binding [GO:0001530]; porin activity [GO:0015288]; protein N-terminus binding [GO:0047485]; ion transmembrane transport [GO:0034220]; protein homotrimerization [GO:0070207] colicin transmembrane transporter activity [GO:0042912]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; ion channel activity [GO:0005216]; ion transmembrane transporter activity [GO:0015075]; lipid binding [GO:0008289]; lipopolysaccharide binding [GO:0001530]; porin activity [GO:0015288]; protein N-terminus binding [GO:0047485] GO:0001530; GO:0005216; GO:0008289; GO:0009279; GO:0015075; GO:0015288; GO:0016021; GO:0034220; GO:0034702; GO:0042802; GO:0042912; GO:0046930; GO:0047485; GO:0070207; GO:0097718 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:2464593}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137}. +P76081 PAAE_ECOLI 1,2-phenylacetyl-CoA epoxidase, subunit E (EC 1.-.-.-) (1,2-phenylacetyl-CoA epoxidase, reductase subunit) (1,2-phenylacetyl-CoA monooxygenase, subunit E) paaE ydbR b1392 JW1387 ydbR paaE 39,320 phenylacetate catabolic process [GO:0010124] 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; phenylacetate catabolic process [GO:0010124] 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872] GO:0009055; GO:0010124; GO:0046872; GO:0050660; GO:0051537 +P02919 PBPB_ECOLI Penicillin-binding protein 1B (PBP-1b) (PBP1b) (Murein polymerase) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase) (Peptidoglycan glycosyltransferase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)] mrcB pbpF ponB b0149 JW0145 pbpF ponB mrcB 94,293 cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; positive regulation of bipolar cell growth [GO:0051518]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677]; response to X-ray [GO:0010165] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; peptidoglycan-based cell wall [GO:0009274]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; peptidoglycan-based cell wall [GO:0009274]; plasma membrane [GO:0005886]; drug binding [GO:0008144]; lipopeptide binding [GO:0071723]; penicillin binding [GO:0008658]; peptidoglycan glycosyltransferase activity [GO:0008955]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; positive regulation of bipolar cell growth [GO:0051518]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677]; response to X-ray [GO:0010165] drug binding [GO:0008144]; lipopeptide binding [GO:0071723]; penicillin binding [GO:0008658]; peptidoglycan glycosyltransferase activity [GO:0008955]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002] GO:0005886; GO:0005887; GO:0008144; GO:0008360; GO:0008658; GO:0008955; GO:0009002; GO:0009252; GO:0009274; GO:0010165; GO:0016020; GO:0030288; GO:0046677; GO:0051518; GO:0071555; GO:0071723 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass type II membrane protein. +P10442 RNH2_ECOLI Ribonuclease HII (RNase HII) (EC 3.1.26.4) rnhB b0183 JW0178 rnhB 21,526 DNA replication, removal of RNA primer [GO:0043137]; mismatch repair [GO:0006298] cytoplasm [GO:0005737]; ribonuclease H2 complex [GO:0032299] cytoplasm [GO:0005737]; ribonuclease H2 complex [GO:0032299]; manganese ion binding [GO:0030145]; RNA binding [GO:0003723]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; DNA replication, removal of RNA primer [GO:0043137]; mismatch repair [GO:0006298] manganese ion binding [GO:0030145]; RNA binding [GO:0003723]; RNA-DNA hybrid ribonuclease activity [GO:0004523] GO:0003723; GO:0004523; GO:0005737; GO:0006298; GO:0030145; GO:0032299; GO:0043137 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AA37 RLUA_ECOLI Dual-specificity RNA pseudouridine synthase RluA (EC 5.4.99.28) (EC 5.4.99.29) (23S rRNA pseudouridine(746) synthase) (Ribosomal large subunit pseudouridine synthase A) (rRNA pseudouridylate synthase A) (rRNA-uridine isomerase A) (tRNA pseudouridine(32) synthase) rluA yabO b0058 JW0057 yabO rluA 24,861 enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; pseudouridine synthesis [GO:0001522]; RNA modification [GO:0009451]; rRNA processing [GO:0006364]; rRNA pseudouridine synthesis [GO:0031118]; tRNA processing [GO:0008033]; tRNA pseudouridine synthesis [GO:0031119] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159]; tRNA pseudouridine synthase activity [GO:0106029]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455]; pseudouridine synthesis [GO:0001522]; RNA modification [GO:0009451]; rRNA processing [GO:0006364]; rRNA pseudouridine synthesis [GO:0031118]; tRNA processing [GO:0008033]; tRNA pseudouridine synthesis [GO:0031119] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159]; tRNA pseudouridine synthase activity [GO:0106029] GO:0000455; GO:0001522; GO:0003723; GO:0006364; GO:0008033; GO:0009451; GO:0009982; GO:0031118; GO:0031119; GO:0106029; GO:0120159 +P0A7T7 RS18_ECOLI 30S ribosomal protein S18 (Small ribosomal subunit protein bS18) rpsR b4202 JW4160 rpsR 8,986 translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; mRNA 5'-UTR binding [GO:0048027]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412] mRNA 5'-UTR binding [GO:0048027]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735] GO:0003735; GO:0005829; GO:0006412; GO:0022627; GO:0048027; GO:0070181 +P75894 RUTE_ECOLI Probable malonic semialdehyde reductase RutE (EC 1.1.1.298) rutE ycdI b1008 JW0993 ycdI rutE 21,570 cellular response to DNA damage stimulus [GO:0006974]; nitrogen utilization [GO:0019740]; pyrimidine nucleobase catabolic process [GO:0006208]; uracil catabolic process [GO:0006212] 3-hydroxypropionate dehydrogenase (NADP+) activity [GO:0035527]; FMN binding [GO:0010181]; cellular response to DNA damage stimulus [GO:0006974]; nitrogen utilization [GO:0019740]; pyrimidine nucleobase catabolic process [GO:0006208]; uracil catabolic process [GO:0006212] 3-hydroxypropionate dehydrogenase (NADP+) activity [GO:0035527]; FMN binding [GO:0010181] GO:0006208; GO:0006212; GO:0006974; GO:0010181; GO:0019740; GO:0035527 +P0A9T0 SERA_ECOLI D-3-phosphoglycerate dehydrogenase (PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) serA b2913 JW2880 serA 44,176 L-serine biosynthetic process [GO:0006564] cytosol [GO:0005829] cytosol [GO:0005829]; 2-hydroxyglutarate dehydrogenase activity [GO:0047545]; glyoxylate reductase (NADP+) activity [GO:0030267]; hydroxypyruvate reductase activity [GO:0016618]; identical protein binding [GO:0042802]; NAD+ binding [GO:0070403]; NADH binding [GO:0070404]; phosphoglycerate dehydrogenase activity [GO:0004617]; serine binding [GO:0070905]; L-serine biosynthetic process [GO:0006564] 2-hydroxyglutarate dehydrogenase activity [GO:0047545]; glyoxylate reductase (NADP+) activity [GO:0030267]; hydroxypyruvate reductase activity [GO:0016618]; identical protein binding [GO:0042802]; NAD+ binding [GO:0070403]; NADH binding [GO:0070404]; phosphoglycerate dehydrogenase activity [GO:0004617]; serine binding [GO:0070905] GO:0004617; GO:0005829; GO:0006564; GO:0016618; GO:0030267; GO:0042802; GO:0047545; GO:0070403; GO:0070404; GO:0070905 +P0AAD2 MTR_ECOLI Tryptophan-specific transport protein (Tryptophan permease) mtr b3161 JW3130 mtr 44,333 amino acid transmembrane transport [GO:0003333] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; active transmembrane transporter activity [GO:0022804]; high-affinity tryptophan transmembrane transporter activity [GO:0005300]; symporter activity [GO:0015293]; amino acid transmembrane transport [GO:0003333] active transmembrane transporter activity [GO:0022804]; high-affinity tryptophan transmembrane transporter activity [GO:0005300]; symporter activity [GO:0015293] GO:0003333; GO:0005300; GO:0005886; GO:0005887; GO:0015293; GO:0022804 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P67430 NEMR_ECOLI HTH-type transcriptional repressor NemR (Bleach-sensing transcription factor) (Redox-regulated transcription factor NemR) nemR ydhM b1649 JW5874 ydhM nemR 22,275 negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0045892 +P68739 NFI_ECOLI Endonuclease V (EndoV) (EC 3.1.21.7) (Deoxyinosine 3'endonuclease) (Deoxyribonuclease V) (DNase V) nfi yjaF b3998 JW5547 yjaF nfi 24,673 DNA repair [GO:0006281] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; deoxyribonuclease V activity [GO:0043737]; endoribonuclease activity, producing 5'-phosphomonoesters [GO:0016891]; magnesium ion binding [GO:0000287]; single-stranded RNA binding [GO:0003727]; DNA repair [GO:0006281] deoxyribonuclease V activity [GO:0043737]; endoribonuclease activity, producing 5'-phosphomonoesters [GO:0016891]; magnesium ion binding [GO:0000287]; single-stranded RNA binding [GO:0003727] GO:0000287; GO:0003727; GO:0005737; GO:0006281; GO:0016891; GO:0043737 SUBCELLULAR LOCATION: Cytoplasm. +P63020 NFUA_ECOLI Fe/S biogenesis protein NfuA nfuA gntY yhgI b3414 JW3377 gntY yhgI nfuA 20,998 carbon utilization [GO:0015976]; cellular response to iron ion starvation [GO:0010106]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; response to oxidative stress [GO:0006979] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; iron-sulfur cluster carrier activity [GO:0140132]; carbon utilization [GO:0015976]; cellular response to iron ion starvation [GO:0010106]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; response to oxidative stress [GO:0006979] 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; iron-sulfur cluster carrier activity [GO:0140132] GO:0005506; GO:0005829; GO:0006979; GO:0010106; GO:0015976; GO:0016226; GO:0051539; GO:0097428; GO:0106035; GO:0140132 +P32711 NRFF_ECOLI Formate-dependent nitrite reductase complex subunit NrfF nrfF yjcM b4075 JW4036 yjcM nrfF 14,523 cytochrome c-heme linkage via heme-L-cysteine [GO:0018378] periplasmic space [GO:0042597]; plasma membrane [GO:0005886] periplasmic space [GO:0042597]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; cytochrome c-heme linkage via heme-L-cysteine [GO:0018378] metal ion binding [GO:0046872] GO:0005886; GO:0018378; GO:0042597; GO:0046872 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P27434 RODZ_ECOLI Cytoskeleton protein RodZ rodZ yfgA b2516 JW2500 yfgA rodZ 36,192 FtsZ-dependent cytokinesis [GO:0043093]; regulation of cell shape [GO:0008360] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; DNA binding [GO:0003677]; FtsZ-dependent cytokinesis [GO:0043093]; regulation of cell shape [GO:0008360] DNA binding [GO:0003677] GO:0003677; GO:0005887; GO:0008360; GO:0043093 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:19008860}; Single-pass type II membrane protein {ECO:0000269|PubMed:19008860}. Note=Forms helical filaments along the long axis of the cell. +P0A805 RRF_ECOLI Ribosome-recycling factor (RRF) (Ribosome-releasing factor) frr rrf b0172 JW0167 rrf frr 20,639 cytoplasmic translational termination [GO:0002184]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribosomal large subunit binding [GO:0043023]; cytoplasmic translational termination [GO:0002184]; translation [GO:0006412] ribosomal large subunit binding [GO:0043023] GO:0002184; GO:0005737; GO:0005829; GO:0006412; GO:0043023 SUBCELLULAR LOCATION: Cytoplasm. +P46850 RTCB_ECOLI RNA-splicing ligase RtcB (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase) rtcB yhgL b3421 JW3384 yhgL rtcB 45,222 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; RNA processing [GO:0006396]; RNA repair [GO:0042245]; tRNA processing [GO:0008033] DNA ligase activity [GO:0003909]; GTP binding [GO:0005525]; manganese ion binding [GO:0030145]; RNA ligase activity [GO:0008452]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; RNA processing [GO:0006396]; RNA repair [GO:0042245]; tRNA processing [GO:0008033] DNA ligase activity [GO:0003909]; GTP binding [GO:0005525]; manganese ion binding [GO:0030145]; RNA ligase activity [GO:0008452] GO:0003909; GO:0005525; GO:0006281; GO:0006396; GO:0006974; GO:0008033; GO:0008452; GO:0030145; GO:0042245 +P58041 RZOD_ECOLI Prophage outer membrane lipoprotein RzoD (o-spanin) (Outer membrane lipoprotein Rz1 from lambdoid prophage DLP12) (Spanin from lambdoid prophage DLP12, outer membrane subunit) rzoD b4510 JW5080 rzoD 6,690 cytolysis [GO:0019835]; viral release from host cell [GO:0019076] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; cytolysis [GO:0019835]; viral release from host cell [GO:0019076] GO:0009279; GO:0019076; GO:0019835 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}; Periplasmic side {ECO:0000250}. +P00634 PPB_ECOLI Alkaline phosphatase (APase) (EC 3.1.3.1) phoA b0383 JW0374 phoA 49,439 dephosphorylation [GO:0016311]; protein dephosphorylation [GO:0006470] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; alkaline phosphatase activity [GO:0004035]; hydrogenase (acceptor) activity [GO:0033748]; magnesium ion binding [GO:0000287]; oxidoreductase activity, acting on phosphorus or arsenic in donors [GO:0030613]; phosphoprotein phosphatase activity [GO:0004721]; zinc ion binding [GO:0008270]; dephosphorylation [GO:0016311]; protein dephosphorylation [GO:0006470] alkaline phosphatase activity [GO:0004035]; hydrogenase (acceptor) activity [GO:0033748]; magnesium ion binding [GO:0000287]; oxidoreductase activity, acting on phosphorus or arsenic in donors [GO:0030613]; phosphoprotein phosphatase activity [GO:0004721]; zinc ion binding [GO:0008270] GO:0000287; GO:0004035; GO:0004721; GO:0006470; GO:0008270; GO:0016311; GO:0030288; GO:0030613; GO:0033748; GO:0042597 SUBCELLULAR LOCATION: Periplasm. +P17888 PRIA_ECOLI Primosomal protein N' (EC 3.6.4.-) (ATP-dependent helicase PriA) (Replication factor Y) priA b3935 JW3906 priA 81,655 DNA-dependent DNA replication [GO:0006261]; DNA recombination [GO:0006310]; DNA replication [GO:0006260]; DNA replication, synthesis of RNA primer [GO:0006269]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair [GO:0006302]; plasmid maintenance [GO:0006276]; response to antibiotic [GO:0046677]; response to gamma radiation [GO:0010332] primosome complex [GO:1990077] primosome complex [GO:1990077]; 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; zinc ion binding [GO:0008270]; DNA recombination [GO:0006310]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of RNA primer [GO:0006269]; DNA unwinding involved in DNA replication [GO:0006268]; DNA-dependent DNA replication [GO:0006261]; double-strand break repair [GO:0006302]; plasmid maintenance [GO:0006276]; response to antibiotic [GO:0046677]; response to gamma radiation [GO:0010332] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; zinc ion binding [GO:0008270] GO:0003677; GO:0004386; GO:0005524; GO:0006260; GO:0006261; GO:0006268; GO:0006269; GO:0006270; GO:0006276; GO:0006302; GO:0006310; GO:0008270; GO:0010332; GO:0043138; GO:0046677; GO:1990077 +P15373 PRLF_ECOLI Antitoxin PrlF (HtrA suppressor protein SohA) prlF sohA b3129 JW3098 sohA prlF 12,359 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of cell growth [GO:0001558] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; toxin-antitoxin pair type II binding [GO:0097351]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of cell growth [GO:0001558] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; toxin-antitoxin pair type II binding [GO:0097351] GO:0001558; GO:0003677; GO:0003700; GO:0005737; GO:0019899; GO:0042802; GO:0045892; GO:0097351 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P24555 PTRB_ECOLI Protease 2 (EC 3.4.21.83) (Oligopeptidase B) (Protease II) ptrB tlp b1845 JW1834 tlp ptrB 79,491 cytoplasm [GO:0005737] cytoplasm [GO:0005737]; oligopeptidase activity [GO:0070012]; serine-type endopeptidase activity [GO:0004252] oligopeptidase activity [GO:0070012]; serine-type endopeptidase activity [GO:0004252] GO:0004252; GO:0005737; GO:0070012 +P20966 PTFBC_ECOLI PTS system fructose-specific EIIB'BC component (EIIB'BC-Fru) [Includes: PTS system fructose-specific EIIB component (EC 2.7.1.202) (EIII-Fru) (Fructose-specific phosphotransferase enzyme IIB component); PTS system fructose-specific EIIC component (Fructose permease IIC component)] fruA ptsF b2167 JW2154 ptsF fruA 57,519 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; carbohydrate:proton symporter activity [GO:0005351]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity [GO:0022877]; protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity [GO:0090582]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] carbohydrate:proton symporter activity [GO:0005351]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity [GO:0022877]; protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity [GO:0090582]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005351; GO:0005886; GO:0009401; GO:0016021; GO:0016301; GO:0022877; GO:0090563; GO:0090582 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00427, ECO:0000269|PubMed:15919996, ECO:0000305|PubMed:3076173}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00427, ECO:0000269|PubMed:15919996, ECO:0000305|PubMed:3076173, ECO:0000305|PubMed:8626640}. +P69828 PTKA_ECOLI PTS system galactitol-specific EIIA component (EIIB-Gat) (Galactitol-specific phosphotransferase enzyme IIA component) gatA b2094 JW2078/JW2081 gatA 16,907 galactitol metabolic process [GO:0019402]; galactitol transport [GO:0015796]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; regulation of ion transmembrane transporter activity [GO:0032412] cytosol [GO:0005829] cytosol [GO:0005829]; kinase activity [GO:0016301]; protein kinase activator activity [GO:0030295]; protein-phosphocysteine-galactitol-phosphotransferase system transporter activity [GO:0090584]; galactitol metabolic process [GO:0019402]; galactitol transport [GO:0015796]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; regulation of ion transmembrane transporter activity [GO:0032412] kinase activity [GO:0016301]; protein kinase activator activity [GO:0030295]; protein-phosphocysteine-galactitol-phosphotransferase system transporter activity [GO:0090584] GO:0005829; GO:0009401; GO:0015796; GO:0016301; GO:0019402; GO:0030295; GO:0032412; GO:0090584 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:8955298}. +P04982 RBSD_ECOLI D-ribose pyranase (EC 5.4.99.62) rbsD b3748 JW5857 rbsD 15,292 D-ribose catabolic process [GO:0019303] cytosol [GO:0005829] cytosol [GO:0005829]; D-ribose pyranase activity [GO:0062193]; identical protein binding [GO:0042802]; intramolecular lyase activity [GO:0016872]; intramolecular transferase activity [GO:0016866]; monosaccharide binding [GO:0048029]; D-ribose catabolic process [GO:0019303] D-ribose pyranase activity [GO:0062193]; identical protein binding [GO:0042802]; intramolecular lyase activity [GO:0016872]; intramolecular transferase activity [GO:0016866]; monosaccharide binding [GO:0048029] GO:0005829; GO:0016866; GO:0016872; GO:0019303; GO:0042802; GO:0048029; GO:0062193 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A7H3 RECO_ECOLI DNA repair protein RecO (Recombination protein O) recO b2565 JW2549 recO 27,391 DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; response to radiation [GO:0009314] bacterial nucleoid [GO:0043590] bacterial nucleoid [GO:0043590]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; response to radiation [GO:0009314] GO:0006302; GO:0006310; GO:0009314; GO:0043590 +P05824 RECN_ECOLI DNA repair protein RecN (Recombination protein N) recN radB b2616 JW5416 radB recN 61,396 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; recombinational interstrand cross-link repair [GO:0036298]; recombinational repair [GO:0000725]; response to ionizing radiation [GO:0010212]; response to radiation [GO:0009314]; response to UV [GO:0009411]; response to X-ray [GO:0010165]; SOS response [GO:0009432] bacterial nucleoid [GO:0043590]; cytosol [GO:0005829] bacterial nucleoid [GO:0043590]; cytosol [GO:0005829]; ATP binding [GO:0005524]; cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; recombinational interstrand cross-link repair [GO:0036298]; recombinational repair [GO:0000725]; response to ionizing radiation [GO:0010212]; response to radiation [GO:0009314]; response to UV [GO:0009411]; response to X-ray [GO:0010165]; SOS response [GO:0009432] ATP binding [GO:0005524] GO:0000724; GO:0000725; GO:0005524; GO:0005829; GO:0006302; GO:0006974; GO:0009314; GO:0009411; GO:0009432; GO:0010165; GO:0010212; GO:0036298; GO:0043590 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21219465}. Note=In 70% of cell localizes to discrete nucleoid foci (probable DNA damage sites) upon treatment with mitomycin C (MMC) for 2 hours. +P52119 RATB_ECOLI UPF0125 protein RatB ratB pasI yfjF b2618 JW2599 pasI yfjF ratB 10,789 +P75876 RLMI_ECOLI Ribosomal RNA large subunit methyltransferase I (EC 2.1.1.191) (23S rRNA m5C1962 methyltransferase) (rRNA (cytosine-C(5)-)-methyltransferase RlmI) rlmI yccW b0967 JW5898 yccW rlmI 44,357 rRNA base methylation [GO:0070475]; rRNA methylation [GO:0031167] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; RNA binding [GO:0003723]; rRNA (cytosine) methyltransferase activity [GO:0016434]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383]; rRNA base methylation [GO:0070475]; rRNA methylation [GO:0031167] RNA binding [GO:0003723]; rRNA (cytosine) methyltransferase activity [GO:0016434]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383] GO:0003723; GO:0005737; GO:0005829; GO:0009383; GO:0016434; GO:0031167; GO:0070475 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A809 RUVA_ECOLI Holliday junction ATP-dependent DNA helicase RuvA (EC 3.6.4.12) ruvA b1861 JW1850 ruvA 22,086 recombinational repair [GO:0000725]; response to radiation [GO:0009314]; SOS response [GO:0009432] cytoplasm [GO:0005737]; Holliday junction helicase complex [GO:0009379]; Holliday junction resolvase complex [GO:0048476] cytoplasm [GO:0005737]; Holliday junction helicase complex [GO:0009379]; Holliday junction resolvase complex [GO:0048476]; ATP binding [GO:0005524]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; identical protein binding [GO:0042802]; recombinational repair [GO:0000725]; response to radiation [GO:0009314]; SOS response [GO:0009432] ATP binding [GO:0005524]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; identical protein binding [GO:0042802] GO:0000400; GO:0000725; GO:0005524; GO:0005737; GO:0009314; GO:0009378; GO:0009379; GO:0009432; GO:0042802; GO:0048476 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21219465}. Note=In 15% of cell localizes to discrete nucleoid foci (probable DNA damage sites) upon treatment with mitomycin C (MMC) for 2 hours. +P77285 RSXG_ECOLI Ion-translocating oxidoreductase complex subunit G (EC 7.-.-.-) (Rsx electron transport complex subunit G) rsxG rnfG ydgP b1631 JW1623 rnfG ydgP rsxG 21,912 cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; FMN binding [GO:0010181] electron transfer activity [GO:0009055]; FMN binding [GO:0010181] GO:0005886; GO:0009055; GO:0009279; GO:0010181; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00479, ECO:0000305}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00479}. +P0AC98 SATP_ECOLI Succinate-acetate/proton symporter SatP (Succinate-acetate transporter protein) satP yaaH b0010 JW0009 yaaH satP 20,071 acetate transmembrane transport [GO:0035433]; succinate transmembrane transport [GO:0071422] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; acetate:proton symporter activity [GO:0015360]; acetate transmembrane transport [GO:0035433]; succinate transmembrane transport [GO:0071422] acetate:proton symporter activity [GO:0015360] GO:0005886; GO:0015360; GO:0016021; GO:0035433; GO:0071422 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0ACC1 PRMC_ECOLI Release factor glutamine methyltransferase (RF MTase) (EC 2.1.1.297) (M.EcoKHemKP) (N5-glutamine methyltransferase PrmC) (Protein release factor methylation C) (Protein-(glutamine-N5) MTase PrmC) (Protein-glutamine N-methyltransferase PrmC) prmC hemK b1212 JW1203 hemK prmC 30,975 peptidyl-glutamine methylation [GO:0018364]; protein methylation [GO:0006479]; regulation of gene expression [GO:0010468]; translational termination [GO:0006415] nucleic acid binding [GO:0003676]; protein methyltransferase activity [GO:0008276]; protein-(glutamine-N5) methyltransferase activity [GO:0102559]; protein-glutamine N-methyltransferase activity [GO:0036009]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; peptidyl-glutamine methylation [GO:0018364]; protein methylation [GO:0006479]; regulation of gene expression [GO:0010468]; translational termination [GO:0006415] nucleic acid binding [GO:0003676]; protein-(glutamine-N5) methyltransferase activity [GO:0102559]; protein-glutamine N-methyltransferase activity [GO:0036009]; protein methyltransferase activity [GO:0008276]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757] GO:0003676; GO:0006415; GO:0006479; GO:0008276; GO:0008757; GO:0010468; GO:0018364; GO:0036009; GO:0102559 +P69786 PTGCB_ECOLI PTS system glucose-specific EIICB component (EIICB-Glc) (EII-Glc) [Includes: Glucose permease IIC component (PTS system glucose-specific EIIC component); Glucose-specific phosphotransferase enzyme IIB component (EC 2.7.1.199) (PTS system glucose-specific EIIB component)] ptsG glcA umg b1101 JW1087 glcA umg ptsG 50,677 glucose transmembrane transport [GO:1904659]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; glucose transmembrane transporter activity [GO:0005355]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-glucose phosphotransferase system transporter activity [GO:0090564]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; glucose transmembrane transport [GO:1904659]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] glucose transmembrane transporter activity [GO:0005355]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-glucose phosphotransferase system transporter activity [GO:0090564]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005355; GO:0005829; GO:0005886; GO:0005887; GO:0008982; GO:0009401; GO:0016301; GO:0090563; GO:0090564; GO:1904659 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00426, ECO:0000269|PubMed:15919996, ECO:0000305|PubMed:3129430}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00426, ECO:0000305|PubMed:15919996}. +P33644 PURNU_ECOLI Purine nucleoside phosphorylase YfiH (EC 2.4.2.1) (Adenosine deaminase YfiH) (EC 3.5.4.4) (Polyphenol oxidase YfiH) (EC 1.10.3.-) (S-methyl-5'-thioadenosine phosphorylase YfiH) (EC 2.4.2.28) yfiH b2593 JW2575 yfiH 26,339 cytosol [GO:0005829] cytosol [GO:0005829]; adenosine deaminase activity [GO:0004000]; copper ion binding [GO:0005507]; oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [GO:0016682]; protein homodimerization activity [GO:0042803]; purine-nucleoside phosphorylase activity [GO:0004731]; S-methyl-5-thioadenosine phosphorylase activity [GO:0017061] adenosine deaminase activity [GO:0004000]; copper ion binding [GO:0005507]; oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [GO:0016682]; protein homodimerization activity [GO:0042803]; purine-nucleoside phosphorylase activity [GO:0004731]; S-methyl-5-thioadenosine phosphorylase activity [GO:0017061] GO:0004000; GO:0004731; GO:0005507; GO:0005829; GO:0016682; GO:0017061; GO:0042803 +P77379 RCLR_ECOLI RCS-specific HTH-type transcriptional activator RclR (Reactive chlorine resistance protein R) rclR ykgD b0305 JW0298 ykgD rclR 31,474 positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cellular organohalogen metabolic process [GO:0090347] DNA-binding transcription activator activity [GO:0001216]; sequence-specific DNA binding [GO:0043565]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cellular organohalogen metabolic process [GO:0090347] DNA-binding transcription activator activity [GO:0001216]; sequence-specific DNA binding [GO:0043565] GO:0001216; GO:0043565; GO:0045893; GO:0090347 +P15043 RECQ_ECOLI ATP-dependent DNA helicase RecQ (EC 3.6.4.12) recQ b3822 JW5855 recQ 68,364 cellular response to DNA damage stimulus [GO:0006974]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432] bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]; single-stranded DNA-dependent ATP-dependent DNA helicase complex [GO:0017117] bacterial nucleoid [GO:0043590]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; replisome [GO:0030894]; single-stranded DNA-dependent ATP-dependent DNA helicase complex [GO:0017117]; 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; four-way junction helicase activity [GO:0009378]; single-stranded DNA helicase activity [GO:0017116]; transition metal ion binding [GO:0046914]; zinc ion binding [GO:0008270]; cellular response to DNA damage stimulus [GO:0006974]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432] 3'-5' DNA helicase activity [GO:0043138]; ATPase activity [GO:0016887]; ATPase activity, acting on DNA [GO:0008094]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; four-way junction helicase activity [GO:0009378]; single-stranded DNA helicase activity [GO:0017116]; transition metal ion binding [GO:0046914]; zinc ion binding [GO:0008270] GO:0003677; GO:0003678; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0006974; GO:0008094; GO:0008270; GO:0009378; GO:0009432; GO:0016887; GO:0017116; GO:0017117; GO:0030894; GO:0032508; GO:0043138; GO:0043590; GO:0046914 +P33919 RADD_ECOLI Putative DNA repair helicase RadD (EC 3.6.4.12) radD yejH yejI yejJ b2184 JW2172 yejH yejI yejJ radD 66,413 cell division [GO:0051301]; double-strand break repair [GO:0006302]; response to drug [GO:0042493]; response to ionizing radiation [GO:0010212]; translation [GO:0006412] ATP binding [GO:0005524]; ATPase activity [GO:0016887]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270]; cell division [GO:0051301]; double-strand break repair [GO:0006302]; response to drug [GO:0042493]; response to ionizing radiation [GO:0010212]; translation [GO:0006412] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270] GO:0003678; GO:0003697; GO:0005524; GO:0006302; GO:0006412; GO:0008270; GO:0010212; GO:0016887; GO:0042493; GO:0051301 +P37746 RFBX_ECOLI Putative O-antigen transporter rfbX wzx b2037 JW2022 wzx rfbX 45,383 cellular response to DNA damage stimulus [GO:0006974]; O antigen biosynthetic process [GO:0009243]; response to antibiotic [GO:0046677] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cellular response to DNA damage stimulus [GO:0006974]; O antigen biosynthetic process [GO:0009243]; response to antibiotic [GO:0046677] GO:0005886; GO:0005887; GO:0006974; GO:0009243; GO:0046677 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P60422 RL2_ECOLI 50S ribosomal protein L2 (Large ribosomal subunit protein uL2) rplB b3317 JW3279 rplB 29,860 cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027] RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270] GO:0000027; GO:0002181; GO:0003723; GO:0003735; GO:0005829; GO:0008270; GO:0016740; GO:0019843; GO:0022625 +P0A766 RSXA_ECOLI Ion-translocating oxidoreductase complex subunit A (EC 7.-.-.-) (Rsx electron transport complex subunit A) rsxA rnfA ydgL b1627 JW1619 rnfA ydgL rsxA 20,898 electron transport chain [GO:0022900] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; electron transport chain [GO:0022900] GO:0005886; GO:0016021; GO:0022900 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00459, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00459}. +P0AG74 RUSA_ECOLI Crossover junction endodeoxyribonuclease RusA (EC 3.1.22.4) (Holliday junction nuclease RusA) (Holliday junction resolvase) rusA rus ybcP b0550 JW0538 rus ybcP rusA 13,846 DNA recombination [GO:0006310]; DNA repair [GO:0006281] crossover junction endodeoxyribonuclease activity [GO:0008821]; four-way junction DNA binding [GO:0000400]; magnesium ion binding [GO:0000287]; DNA recombination [GO:0006310]; DNA repair [GO:0006281] crossover junction endodeoxyribonuclease activity [GO:0008821]; four-way junction DNA binding [GO:0000400]; magnesium ion binding [GO:0000287] GO:0000287; GO:0000400; GO:0006281; GO:0006310; GO:0008821 +P15254 PUR4_ECOLI Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) purL purI b2557 JW2541 purI purL 141,403 'de novo' IMP biosynthetic process [GO:0006189]; glutamine metabolic process [GO:0006541] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; metal ion binding [GO:0046872]; phosphoribosylformylglycinamidine synthase activity [GO:0004642]; 'de novo' IMP biosynthetic process [GO:0006189]; glutamine metabolic process [GO:0006541] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylformylglycinamidine synthase activity [GO:0004642] GO:0004642; GO:0005524; GO:0005737; GO:0005829; GO:0006189; GO:0006541; GO:0016887; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00419, ECO:0000269|PubMed:2659070}. +P77272 PTYBC_ECOLI PTS system N-acetylmuramic acid-specific EIIBC component (EIIBC-MurNAc) [Includes: N-acetylmuramic acid-specific phosphotransferase enzyme IIB component (EC 2.7.1.192) (PTS system N-acetylmuramic acid-specific EIIB component); N-acetylmuramic acid permease IIC component (PTS system N-acetylmuramic acid-specific EIIC component)] murP yfeV b2429 JW2422 yfeV murP 49,802 carbohydrate transmembrane transport [GO:0034219]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity [GO:0090588]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; carbohydrate transmembrane transport [GO:0034219]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity [GO:0090588]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005886; GO:0005887; GO:0008982; GO:0009401; GO:0016020; GO:0016301; GO:0034219; GO:0090563; GO:0090588 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00426}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00426}. +P0A8K1 PSD_ECOLI Phosphatidylserine decarboxylase proenzyme (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain] psd b4160 JW4121 psd 35,934 phosphatidylethanolamine biosynthetic process [GO:0006646]; protein autoprocessing [GO:0016540]; zymogen activation [GO:0031638] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; phosphatidylserine decarboxylase activity [GO:0004609]; phosphatidylethanolamine biosynthetic process [GO:0006646]; protein autoprocessing [GO:0016540]; zymogen activation [GO:0031638] phosphatidylserine decarboxylase activity [GO:0004609] GO:0004609; GO:0005886; GO:0006646; GO:0016540; GO:0031638 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00662, ECO:0000269|PubMed:4598120}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00662, ECO:0000269|PubMed:4598120}. +P0A8A4 PSRP_ECOLI Phosphoenolpyruvate synthase regulatory protein (PEP synthase regulatory protein) (PSRP) (EC 2.7.11.33) (EC 2.7.4.28) (Pyruvate, water dikinase regulatory protein) ppsR ydiA b1703 JW1693 ydiA ppsR 31,211 protein dephosphorylation [GO:0006470] cytosol [GO:0005829] cytosol [GO:0005829]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; enzyme regulator activity [GO:0030234]; phosphotransferase activity, phosphate group as acceptor [GO:0016776]; protein serine/threonine kinase activity [GO:0004674]; protein dephosphorylation [GO:0006470] ADP binding [GO:0043531]; ATP binding [GO:0005524]; enzyme regulator activity [GO:0030234]; phosphotransferase activity, phosphate group as acceptor [GO:0016776]; protein serine/threonine kinase activity [GO:0004674] GO:0004674; GO:0005524; GO:0005829; GO:0006470; GO:0016776; GO:0030234; GO:0043531 +P76425 RCNA_ECOLI Nickel/cobalt efflux system RcnA rcnA yohM b2106 JW2093 yohM rcnA 30,419 cobalt ion transport [GO:0006824]; nickel cation homeostasis [GO:0035784]; nickel cation transmembrane transport [GO:0035444]; response to cobalt ion [GO:0032025]; response to nickel cation [GO:0010045] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cation efflux transmembrane transporter activity [GO:0046583]; nickel cation transmembrane transporter activity [GO:0015099]; cobalt ion transport [GO:0006824]; nickel cation homeostasis [GO:0035784]; nickel cation transmembrane transport [GO:0035444]; response to cobalt ion [GO:0032025]; response to nickel cation [GO:0010045] cation efflux transmembrane transporter activity [GO:0046583]; nickel cation transmembrane transporter activity [GO:0015099] GO:0005886; GO:0005887; GO:0006824; GO:0010045; GO:0015099; GO:0032025; GO:0035444; GO:0035784; GO:0046583 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15805538}; Multi-pass membrane protein {ECO:0000269|PubMed:15805538}. +P0C0U4 RIMK_ECOLI Ribosomal protein S6--L-glutamate ligase (EC 6.3.2.-) (Polyglutamate synthase) (Ribosomal protein S6 modification protein) rimK b0852 JW0836 rimK 32,436 C-terminal protein amino acid modification [GO:0018410]; SOS response [GO:0009432]; translation [GO:0006412] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; ligase activity, forming carbon-nitrogen bonds [GO:0016879]; metal ion binding [GO:0046872]; ribosomal S6-glutamic acid ligase activity [GO:0018169]; C-terminal protein amino acid modification [GO:0018410]; SOS response [GO:0009432]; translation [GO:0006412] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; ligase activity, forming carbon-nitrogen bonds [GO:0016879]; metal ion binding [GO:0046872]; ribosomal S6-glutamic acid ligase activity [GO:0018169] GO:0005524; GO:0005737; GO:0006412; GO:0009432; GO:0016879; GO:0018169; GO:0018410; GO:0042802; GO:0046872 +P37748 RFC_ECOLI O-antigen polymerase rfc yefF b2035 JW2020 yefF rfc 44,744 lipopolysaccharide biosynthetic process [GO:0009103] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; lipopolysaccharide biosynthetic process [GO:0009103] GO:0005886; GO:0009103; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P61714 RISB_ECOLI 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (LS) (Lumazine synthase) (EC 2.5.1.78) ribE ribH ybaF b0415 JW0405 ribH ybaF ribE 16,157 riboflavin biosynthetic process [GO:0009231] cytosol [GO:0005829]; riboflavin synthase complex [GO:0009349] cytosol [GO:0005829]; riboflavin synthase complex [GO:0009349]; 6,7-dimethyl-8-ribityllumazine synthase activity [GO:0000906]; riboflavin biosynthetic process [GO:0009231] 6,7-dimethyl-8-ribityllumazine synthase activity [GO:0000906] GO:0000906; GO:0005829; GO:0009231; GO:0009349 +P37146 RIR4_ECOLI Ribonucleoside-diphosphate reductase 2 subunit beta (EC 1.17.4.1) (R2F protein) (Ribonucleotide reductase 2) nrdF ygaD b2676 JW2651 ygaD nrdF 36,443 deoxyribonucleotide biosynthetic process [GO:0009263]; DNA replication [GO:0006260] cytoplasm [GO:0005737]; ribonucleoside-diphosphate reductase complex [GO:0005971] cytoplasm [GO:0005737]; ribonucleoside-diphosphate reductase complex [GO:0005971]; iron ion binding [GO:0005506]; manganese ion binding [GO:0030145]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA replication [GO:0006260] iron ion binding [GO:0005506]; manganese ion binding [GO:0030145]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748] GO:0004748; GO:0005506; GO:0005737; GO:0005971; GO:0006260; GO:0009263; GO:0030145 +P21499 RNR_ECOLI Ribonuclease R (RNase R) (EC 3.1.13.1) (Protein VacB) rnr vacB yjeC b4179 JW5741 vacB yjeC rnr 92,109 mRNA catabolic process [GO:0006402]; ncRNA processing [GO:0034470]; pathogenesis [GO:0009405]; response to cold [GO:0009409] cytosol [GO:0005829] cytosol [GO:0005829]; 3'-5' RNA helicase activity [GO:0034458]; 3'-5'-exoribonuclease activity [GO:0000175]; exoribonuclease activity, producing 5'-phosphomonoesters [GO:0016896]; exoribonuclease II activity [GO:0008859]; ribonuclease activity [GO:0004540]; ribonuclease R activity [GO:0008997]; RNA binding [GO:0003723]; mRNA catabolic process [GO:0006402]; ncRNA processing [GO:0034470]; pathogenesis [GO:0009405]; response to cold [GO:0009409] 3'-5'-exoribonuclease activity [GO:0000175]; 3'-5' RNA helicase activity [GO:0034458]; exoribonuclease activity, producing 5'-phosphomonoesters [GO:0016896]; exoribonuclease II activity [GO:0008859]; ribonuclease activity [GO:0004540]; ribonuclease R activity [GO:0008997]; RNA binding [GO:0003723] GO:0000175; GO:0003723; GO:0004540; GO:0005829; GO:0006402; GO:0008859; GO:0008997; GO:0009405; GO:0009409; GO:0016896; GO:0034458; GO:0034470 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0CG19 RNPH_ECOLI Truncated inactive ribonuclease PH (Truncated inactive RNase PH) (Inactive RNase PH) (Truncated RNase PH) rph orfE b3643 JW3618 orfE rph 24,425 rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; tRNA processing [GO:0008033] cytosol [GO:0005829] cytosol [GO:0005829]; 3'-5'-exoribonuclease activity [GO:0000175]; tRNA binding [GO:0000049]; tRNA nucleotidyltransferase activity [GO:0009022]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; tRNA processing [GO:0008033] 3'-5'-exoribonuclease activity [GO:0000175]; tRNA binding [GO:0000049]; tRNA nucleotidyltransferase activity [GO:0009022] GO:0000049; GO:0000175; GO:0005829; GO:0006364; GO:0008033; GO:0009022; GO:0016075 +P24207 PHEP_ECOLI Phenylalanine-specific permease pheP b0576 JW0565 pheP 50,677 amino acid transport [GO:0006865]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; amino acid transport [GO:0006865]; transmembrane transport [GO:0055085] GO:0005886; GO:0006865; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P07102 PPA_ECOLI Periplasmic AppA protein [Includes: Phosphoanhydride phosphohydrolase (EC 3.1.3.2) (pH 2.5 acid phosphatase) (AP); 4-phytase (EC 3.1.3.26)] appA b0980 JW0963 appA 47,057 cellular response to anoxia [GO:0071454]; cellular response to phosphate starvation [GO:0016036]; dephosphorylation [GO:0016311]; myo-inositol hexakisphosphate dephosphorylation [GO:0033518] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; 4-phytase activity [GO:0008707]; acid phosphatase activity [GO:0003993]; inositol phosphate phosphatase activity [GO:0052745]; nucleotidase activity [GO:0008252]; phosphatase activity [GO:0016791]; sugar-phosphatase activity [GO:0050308]; cellular response to anoxia [GO:0071454]; cellular response to phosphate starvation [GO:0016036]; dephosphorylation [GO:0016311]; myo-inositol hexakisphosphate dephosphorylation [GO:0033518] 4-phytase activity [GO:0008707]; acid phosphatase activity [GO:0003993]; inositol phosphate phosphatase activity [GO:0052745]; nucleotidase activity [GO:0008252]; phosphatase activity [GO:0016791]; sugar-phosphatase activity [GO:0050308] GO:0003993; GO:0008252; GO:0008707; GO:0016036; GO:0016311; GO:0016791; GO:0030288; GO:0033518; GO:0050308; GO:0052745; GO:0071454 SUBCELLULAR LOCATION: Periplasm. +P76395 PRP3_ECOLI Serine/threonine-protein phosphatase 3 (EC 3.1.3.16) (PP2C-like Ser/Thr phosphatase) (Protein phosphatase C) pphC yegK b2072 JW2057 yegK pphC 27,208 phosphatase activity [GO:0016791]; protein serine phosphatase activity [GO:0106306]; protein threonine phosphatase activity [GO:0106307] phosphatase activity [GO:0016791]; protein serine phosphatase activity [GO:0106306]; protein threonine phosphatase activity [GO:0106307] GO:0016791; GO:0106306; GO:0106307 +P0AB89 PUR8_ECOLI Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) purB b1131 JW1117 purB 51,543 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; cellular response to DNA damage stimulus [GO:0006974] cytosol [GO:0005829] cytosol [GO:0005829]; (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity [GO:0070626]; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [GO:0004018]; 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; cellular response to DNA damage stimulus [GO:0006974] (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity [GO:0070626]; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [GO:0004018] GO:0004018; GO:0005829; GO:0006189; GO:0006974; GO:0044208; GO:0070626 +P50457 PUUE_ECOLI 4-aminobutyrate aminotransferase PuuE (EC 2.6.1.19) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (Glutamate:succinic semialdehyde transaminase) puuE goaG b1302 JW1295 goaG puuE 44,729 gamma-aminobutyric acid catabolic process [GO:0009450]; putrescine catabolic process [GO:0009447] cytosol [GO:0005829] cytosol [GO:0005829]; 4-aminobutyrate transaminase activity [GO:0003867]; 4-aminobutyrate:2-oxoglutarate transaminase activity [GO:0034386]; pyridoxal phosphate binding [GO:0030170]; gamma-aminobutyric acid catabolic process [GO:0009450]; putrescine catabolic process [GO:0009447] 4-aminobutyrate:2-oxoglutarate transaminase activity [GO:0034386]; 4-aminobutyrate transaminase activity [GO:0003867]; pyridoxal phosphate binding [GO:0030170] GO:0003867; GO:0005829; GO:0009447; GO:0009450; GO:0030170; GO:0034386 +Q47274 REQ1_ECOLI Prophage antitermination protein Q homolog QuuD (Antitermination protein Q homolog from lambdoid prophage DLP12) quuD ybcQ b0551 JW0539 ybcQ quuD 14,176 negative regulation of DNA-templated transcription, termination [GO:0060567]; single-species biofilm formation [GO:0044010]; transcription antitermination [GO:0031564] DNA binding [GO:0003677]; negative regulation of DNA-templated transcription, termination [GO:0060567]; single-species biofilm formation [GO:0044010]; transcription antitermination [GO:0031564] DNA binding [GO:0003677] GO:0003677; GO:0031564; GO:0044010; GO:0060567 +P0A7J0 RIBB_ECOLI 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12) ribB htrP b3041 JW3009 htrP ribB 23,353 riboflavin biosynthetic process [GO:0009231] cytosol [GO:0005829]; plasma membrane [GO:0005886] cytosol [GO:0005829]; plasma membrane [GO:0005886]; 3,4-dihydroxy-2-butanone-4-phosphate synthase activity [GO:0008686]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; riboflavin biosynthetic process [GO:0009231] 3,4-dihydroxy-2-butanone-4-phosphate synthase activity [GO:0008686]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145] GO:0000287; GO:0005829; GO:0005886; GO:0008686; GO:0009231; GO:0030145; GO:0042802 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P0AG30 RHO_ECOLI Transcription termination factor Rho (EC 3.6.4.-) (ATP-dependent helicase Rho) rho nitA psuA rnsC sbaA tsu b3783 JW3756 nitA psuA rnsC sbaA tsu rho 47,004 DNA-templated transcription, termination [GO:0006353]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; ATPase activity, acting on RNA [GO:0008186]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; DNA-templated transcription, termination [GO:0006353]; transcription, DNA-templated [GO:0006351] ATPase activity, acting on RNA [GO:0008186]; ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; RNA binding [GO:0003723] GO:0003723; GO:0004386; GO:0005524; GO:0005829; GO:0006351; GO:0006353; GO:0008186; GO:0016020; GO:0016787; GO:0042802 +P42596 RLMG_ECOLI Ribosomal RNA large subunit methyltransferase G (EC 2.1.1.174) (23S rRNA m2G1835 methyltransferase) (rRNA (guanine-N(2)-)-methyltransferase RlmG) rlmG ygjO b3084 JW5513 ygjO rlmG 42,331 rRNA base methylation [GO:0070475] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 23S rRNA (guanine(1835)-N(2))-methyltransferase activity [GO:0052916]; nucleic acid binding [GO:0003676]; rRNA base methylation [GO:0070475] 23S rRNA (guanine(1835)-N(2))-methyltransferase activity [GO:0052916]; nucleic acid binding [GO:0003676] GO:0003676; GO:0005737; GO:0052916; GO:0070475 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A7S3 RS12_ECOLI 30S ribosomal protein S12 (Small ribosomal subunit protein uS12) rpsL strA b3342 JW3304 strA rpsL 13,737 Group I intron splicing [GO:0000372]; maintenance of translational fidelity [GO:1990145]; positive regulation of RNA splicing [GO:0033120]; response to antibiotic [GO:0046677]; RNA folding [GO:0034337]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; ribosome [GO:0005840] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; ribosome [GO:0005840]; misfolded RNA binding [GO:0034336]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049]; Group I intron splicing [GO:0000372]; maintenance of translational fidelity [GO:1990145]; positive regulation of RNA splicing [GO:0033120]; response to antibiotic [GO:0046677]; RNA folding [GO:0034337]; translation [GO:0006412] misfolded RNA binding [GO:0034336]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049] GO:0000049; GO:0000372; GO:0003735; GO:0005829; GO:0005840; GO:0006412; GO:0019843; GO:0022627; GO:0033120; GO:0034336; GO:0034337; GO:0046677; GO:1990145 +P0DPC7 RSED_ECOLI rpoE leader peptide rseD orf51 b4725 orf51 rseD 6,229 regulation of translation [GO:0006417] regulation of translation [GO:0006417] GO:0006417 +P39286 RSGA_ECOLI Small ribosomal subunit biogenesis GTPase RsgA (EC 3.6.1.-) rsgA engC yjeQ b4161 JW4122 engC yjeQ rsgA 39,193 ribosomal small subunit biogenesis [GO:0042274] cytosol [GO:0005829] cytosol [GO:0005829]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanosine tetraphosphate binding [GO:0097216]; metal ion binding [GO:0046872]; rRNA binding [GO:0019843]; ribosomal small subunit biogenesis [GO:0042274] GDP binding [GO:0019003]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; guanosine tetraphosphate binding [GO:0097216]; metal ion binding [GO:0046872]; rRNA binding [GO:0019843] GO:0003924; GO:0005525; GO:0005829; GO:0019003; GO:0019843; GO:0042274; GO:0046872; GO:0097216 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01820, ECO:0000269|PubMed:14973029}. Note=Associates with 30S ribosomes (PubMed:14973029). {ECO:0000269|PubMed:14973029}. +P0A9V8 SQUU_ECOLI 3-sulfolactaldehyde reductase (SLA reductase) (EC 1.1.1.373) yihU b3882 JW3853 yihU 31,158 6-sulfoquinovose(1-) catabolic process [GO:1902777]; 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde [GO:0061720]; protein homotetramerization [GO:0051289]; toxin catabolic process [GO:0009407] 3-sulfolactaldehyde reductase activity [GO:0061596]; 4-hydroxybutyrate dehydrogenase activity [GO:0047577]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; 6-sulfoquinovose(1-) catabolic process [GO:1902777]; 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde [GO:0061720]; protein homotetramerization [GO:0051289]; toxin catabolic process [GO:0009407] 3-sulfolactaldehyde reductase activity [GO:0061596]; 4-hydroxybutyrate dehydrogenase activity [GO:0047577]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] GO:0009407; GO:0016616; GO:0042802; GO:0047577; GO:0050661; GO:0051287; GO:0051289; GO:0061596; GO:0061720; GO:1902777 +P32143 SQUV_ECOLI Sulfofructose kinase (SF kinase) (EC 2.7.1.184) yihV b3883 JW5568 yihV 31,728 6-sulfoquinovose(1-) catabolic process [GO:1902777]; 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde [GO:0061720]; carbohydrate phosphorylation [GO:0046835] cytosol [GO:0005829] cytosol [GO:0005829]; 6-deoxy-6-sulfofructose kinase activity [GO:0061594]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; 6-sulfoquinovose(1-) catabolic process [GO:1902777]; 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde [GO:0061720]; carbohydrate phosphorylation [GO:0046835] 6-deoxy-6-sulfofructose kinase activity [GO:0061594]; ATP binding [GO:0005524]; kinase activity [GO:0016301] GO:0005524; GO:0005829; GO:0016301; GO:0046835; GO:0061594; GO:0061720; GO:1902777 +P27306 STHA_ECOLI Soluble pyridine nucleotide transhydrogenase (STH) (EC 1.6.1.1) (NAD(P)(+) transhydrogenase [B-specific]) sthA sth udhA b3962 JW5551 sth udhA sthA 51,560 cell redox homeostasis [GO:0045454]; NADP metabolic process [GO:0006739] cytosol [GO:0005829] cytosol [GO:0005829]; dihydrolipoyl dehydrogenase activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; NAD(P)+ transhydrogenase (B-specific) activity [GO:0003957]; NAD(P)+ transhydrogenase activity [GO:0008746]; cell redox homeostasis [GO:0045454]; NADP metabolic process [GO:0006739] dihydrolipoyl dehydrogenase activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; NAD(P)+ transhydrogenase (B-specific) activity [GO:0003957]; NAD(P)+ transhydrogenase activity [GO:0008746] GO:0003957; GO:0004148; GO:0005829; GO:0006739; GO:0008746; GO:0042802; GO:0045454; GO:0050660 SUBCELLULAR LOCATION: Cytoplasm. +P62517 OPGH_ECOLI Glucans biosynthesis glucosyltransferase H (EC 2.4.1.-) mdoH opgH b1049 JW1037 opgH mdoH 96,937 beta-glucan biosynthetic process [GO:0051274] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transferase activity, transferring hexosyl groups [GO:0016758]; beta-glucan biosynthetic process [GO:0051274] transferase activity, transferring hexosyl groups [GO:0016758] GO:0005886; GO:0016021; GO:0016758; GO:0051274 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P16685 PHNG_ECOLI Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG (RPnTP synthase subunit PhnG) (EC 2.7.8.37) phnG b4101 JW4062 phnG 16,540 organic phosphonate catabolic process [GO:0019700]; organic phosphonate transport [GO:0015716] alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex [GO:0061694]; carbon phosphorus lyase complex [GO:1904176] alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex [GO:0061694]; carbon phosphorus lyase complex [GO:1904176]; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity [GO:0061693]; organic phosphonate catabolic process [GO:0019700]; organic phosphonate transport [GO:0015716] alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity [GO:0061693] GO:0015716; GO:0019700; GO:0061693; GO:0061694; GO:1904176 +P18133 PNCB_ECOLI Nicotinate phosphoribosyltransferase (NAPRTase) (EC 6.3.4.21) pncB b0931 JW0914 pncB 45,897 NAD biosynthetic process [GO:0009435]; NAD salvage [GO:0034355]; response to heat [GO:0009408] cytosol [GO:0005829] cytosol [GO:0005829]; ligase activity, forming carbon-nitrogen bonds [GO:0016879]; nicotinate phosphoribosyltransferase activity [GO:0004516]; nicotinate-nucleotide diphosphorylase (carboxylating) activity [GO:0004514]; NAD biosynthetic process [GO:0009435]; NAD salvage [GO:0034355]; response to heat [GO:0009408] ligase activity, forming carbon-nitrogen bonds [GO:0016879]; nicotinate-nucleotide diphosphorylase (carboxylating) activity [GO:0004514]; nicotinate phosphoribosyltransferase activity [GO:0004516] GO:0004514; GO:0004516; GO:0005829; GO:0009408; GO:0009435; GO:0016879; GO:0034355 +P0AGH8 PSTC_ECOLI Phosphate transport system permease protein PstC pstC phoW b3727 JW3705 phoW pstC 34,121 phosphate ion transmembrane transport [GO:0035435]; regulation of phosphatase activity [GO:0010921]; response to radiation [GO:0009314] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; inorganic phosphate transmembrane transporter activity [GO:0005315]; phosphate ion transmembrane transport [GO:0035435]; regulation of phosphatase activity [GO:0010921]; response to radiation [GO:0009314] inorganic phosphate transmembrane transporter activity [GO:0005315] GO:0005315; GO:0005886; GO:0005887; GO:0009314; GO:0010921; GO:0035435 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0ACP7 PURR_ECOLI HTH-type transcriptional repressor PurR (Pur regulon repressor) (Purine nucleotide synthesis repressor) purR b1658 JW1650 purR 38,175 negative regulation of purine nucleotide biosynthetic process [GO:1900372]; negative regulation of transcription, DNA-templated [GO:0045892]; purine nucleotide biosynthetic process [GO:0006164]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity [GO:0001217]; guanine binding [GO:0002057]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of purine nucleotide biosynthetic process [GO:1900372]; negative regulation of transcription, DNA-templated [GO:0045892]; purine nucleotide biosynthetic process [GO:0006164]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity [GO:0001217]; guanine binding [GO:0002057]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0001217; GO:0002057; GO:0003700; GO:0005829; GO:0006164; GO:0006355; GO:0045892; GO:1900372 +P33228 RECT_ECOLI Protein RecT (P33) recT b1349 JW1343 recT 29,721 DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310] protein-DNA complex [GO:0032993] protein-DNA complex [GO:0032993]; DNA binding [GO:0003677]; single-stranded DNA binding [GO:0003697]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310] DNA binding [GO:0003677]; single-stranded DNA binding [GO:0003697] GO:0003677; GO:0003697; GO:0006310; GO:0032508; GO:0032993 +P39452 RIR3_ECOLI Ribonucleoside-diphosphate reductase 2 subunit alpha (EC 1.17.4.1) (R1E protein) (Ribonucleotide reductase 2) nrdE b2675 JW2650 nrdE 80,479 deoxyribonucleotide biosynthetic process [GO:0009263]; DNA replication [GO:0006260]; nucleobase-containing small molecule interconversion [GO:0015949] cytoplasm [GO:0005737]; ribonucleoside-diphosphate reductase complex [GO:0005971] cytoplasm [GO:0005737]; ribonucleoside-diphosphate reductase complex [GO:0005971]; ATP binding [GO:0005524]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA replication [GO:0006260]; nucleobase-containing small molecule interconversion [GO:0015949] ATP binding [GO:0005524]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748] GO:0004748; GO:0005524; GO:0005737; GO:0005971; GO:0006260; GO:0009263; GO:0015949 +P0A8R0 RRAA_ECOLI Regulator of ribonuclease activity A rraA menG yiiV b3929 JW3900 menG yiiV rraA 17,360 negative regulation of endoribonuclease activity [GO:0060702]; negative regulation of RNA catabolic process [GO:1902369]; protein homotrimerization [GO:0070207] cytosol [GO:0005829] cytosol [GO:0005829]; endoribonuclease inhibitor activity [GO:0060698]; enzyme binding [GO:0019899]; ribonuclease inhibitor activity [GO:0008428]; negative regulation of endoribonuclease activity [GO:0060702]; negative regulation of RNA catabolic process [GO:1902369]; protein homotrimerization [GO:0070207] endoribonuclease inhibitor activity [GO:0060698]; enzyme binding [GO:0019899]; ribonuclease inhibitor activity [GO:0008428] GO:0005829; GO:0008428; GO:0019899; GO:0060698; GO:0060702; GO:0070207; GO:1902369 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0DP89 ILVGP_ECOLI Putative acetolactate synthase isozyme 2 large subunit (AHAS-II) (ALS-II) (Acetohydroxy-acid synthase II large subunit) ilvG b4488 b3767 ilvG 34,507 isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] acetolactate synthase complex [GO:0005948] acetolactate synthase complex [GO:0005948]; acetolactate synthase activity [GO:0003984]; flavin adenine dinucleotide binding [GO:0050660]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976]; isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] acetolactate synthase activity [GO:0003984]; flavin adenine dinucleotide binding [GO:0050660]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976] GO:0000287; GO:0003984; GO:0005948; GO:0009097; GO:0009099; GO:0030976; GO:0050660 +P69210 MDTI_ECOLI Spermidine export protein MdtI mdtI ydgE b1599 JW1591 ydgE mdtI 11,720 choline transport [GO:0015871]; glycine betaine transport [GO:0031460]; spermidine transmembrane transport [GO:1903711]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; amino-acid betaine transmembrane transporter activity [GO:0015199]; antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; spermidine transmembrane transporter activity [GO:0015606]; transmembrane transporter activity [GO:0022857]; choline transport [GO:0015871]; glycine betaine transport [GO:0031460]; spermidine transmembrane transport [GO:1903711]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] amino-acid betaine transmembrane transporter activity [GO:0015199]; antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; spermidine transmembrane transporter activity [GO:0015606]; transmembrane transporter activity [GO:0022857] GO:0005887; GO:0015199; GO:0015220; GO:0015297; GO:0015606; GO:0015871; GO:0022857; GO:0031460; GO:0055085; GO:1903711; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AE70 MAZF_ECOLI Endoribonuclease toxin MazF (EC 3.1.27.-) (Toxin MazF) (mRNA interferase MazF) mazF chpA chpAK b2782 JW2753 chpA chpAK mazF 12,098 defense response to virus [GO:0051607]; mRNA catabolic process [GO:0006402]; negative regulation of cell growth [GO:0030308]; positive regulation of programmed cell death [GO:0043068]; quorum sensing [GO:0009372]; regulation of translation [GO:0006417]; rRNA catabolic process [GO:0016075] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; DNA binding [GO:0003677]; endoribonuclease activity [GO:0004521]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; defense response to virus [GO:0051607]; mRNA catabolic process [GO:0006402]; negative regulation of cell growth [GO:0030308]; positive regulation of programmed cell death [GO:0043068]; quorum sensing [GO:0009372]; regulation of translation [GO:0006417]; rRNA catabolic process [GO:0016075] DNA binding [GO:0003677]; endoribonuclease activity [GO:0004521]; protein-containing complex binding [GO:0044877]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723] GO:0003677; GO:0003723; GO:0004521; GO:0006402; GO:0006417; GO:0009372; GO:0016075; GO:0030308; GO:0032991; GO:0042803; GO:0043068; GO:0044877; GO:0051607 +P0DPC6 IDLP_ECOLI iraD leader peptide idlP orf27 b4722 orf27 idlP 3,016 regulation of translation [GO:0006417] regulation of translation [GO:0006417] GO:0006417 +P37339 LHGD_ECOLI L-2-hydroxyglutarate dehydrogenase (L2HG dehydrogenase) (EC 1.1.5.13) (L2HG:quinone oxidoreductase) lhgD lhgO ygaF b2660 JW2635 lhgO ygaF lhgD 46,082 L-lysine catabolic process [GO:0019477]; lysine catabolic process [GO:0006554] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; (S)-2-hydroxy-acid oxidase activity [GO:0003973]; 2-hydroxyglutarate dehydrogenase activity [GO:0047545]; flavin adenine dinucleotide binding [GO:0050660]; L-2-hydroxyglutarate oxidase activity [GO:0034419]; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [GO:0016901]; L-lysine catabolic process [GO:0019477]; lysine catabolic process [GO:0006554] (S)-2-hydroxy-acid oxidase activity [GO:0003973]; 2-hydroxyglutarate dehydrogenase activity [GO:0047545]; flavin adenine dinucleotide binding [GO:0050660]; L-2-hydroxyglutarate oxidase activity [GO:0034419]; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [GO:0016901] GO:0003973; GO:0005737; GO:0005886; GO:0006554; GO:0016901; GO:0019477; GO:0034419; GO:0047545; GO:0050660 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:30498244}. +P76343 MSRQ_ECOLI Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ (Flavocytochrome MsrQ) msrQ yedZ b1972 JW1955 yedZ msrQ 24,068 protein repair [GO:0030091] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; FMN binding [GO:0010181]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on diphenols and related substances as donors [GO:0016679]; protein repair [GO:0030091] electron transfer activity [GO:0009055]; FMN binding [GO:0010181]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on diphenols and related substances as donors [GO:0016679] GO:0005886; GO:0005887; GO:0009055; GO:0010181; GO:0016679; GO:0020037; GO:0030091; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01207, ECO:0000305|PubMed:26641313}. +P0AB67 PNTB_ECOLI NAD(P) transhydrogenase subunit beta (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase subunit beta) (Pyridine nucleotide transhydrogenase subunit beta) pntB b1602 JW1594 pntB 48,723 NADPH regeneration [GO:0006740] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; NAD(P)+ transhydrogenase (AB-specific) activity [GO:0008750]; NAD(P)+ transhydrogenase activity [GO:0008746]; NADP binding [GO:0050661]; NADPH regeneration [GO:0006740] NAD(P)+ transhydrogenase (AB-specific) activity [GO:0008750]; NAD(P)+ transhydrogenase activity [GO:0008746]; NADP binding [GO:0050661] GO:0005886; GO:0005887; GO:0006740; GO:0008746; GO:0008750; GO:0050661 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P36647 PPDD_ECOLI Prepilin peptidase-dependent protein D ppdD b0108 JW0104 ppdD 15,622 type IV pilus biogenesis [GO:0043683]; type IV pilus-dependent motility [GO:0043107] integral component of membrane [GO:0016021]; type IV pilus [GO:0044096] integral component of membrane [GO:0016021]; type IV pilus [GO:0044096]; type IV pilus biogenesis [GO:0043683]; type IV pilus-dependent motility [GO:0043107] GO:0016021; GO:0043107; GO:0043683; GO:0044096 SUBCELLULAR LOCATION: Fimbrium. Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. +P0AFK4 POTB_ECOLI Spermidine/putrescine transport system permease protein PotB potB b1125 JW1111 potB 31,062 putrescine transport [GO:0015847]; spermidine transmembrane transport [GO:1903711] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ABC-type polyamine transporter activity [GO:0015417]; putrescine transport [GO:0015847]; spermidine transmembrane transport [GO:1903711] ABC-type polyamine transporter activity [GO:0015417] GO:0005886; GO:0005887; GO:0015417; GO:0015847; GO:0043190; GO:1903711 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AES6 GYRB_ECOLI DNA gyrase subunit B (EC 5.6.2.2) (Type IIA topoisomerase subunit GyrB) gyrB acrB cou himB hisU nalC parA pcbA b3699 JW5625 acrB cou himB hisU nalC parA pcbA gyrB 89,950 DNA-dependent DNA replication [GO:0006261]; DNA topological change [GO:0006265]; response to antibiotic [GO:0046677]; response to drug [GO:0042493]; transcription, DNA-templated [GO:0006351] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex [GO:0009330] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex [GO:0009330]; ATP binding [GO:0005524]; ATPase activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA negative supercoiling activity [GO:0034335]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; metal ion binding [GO:0046872]; DNA topological change [GO:0006265]; DNA-dependent DNA replication [GO:0006261]; response to antibiotic [GO:0046677]; response to drug [GO:0042493]; transcription, DNA-templated [GO:0006351] ATPase activity, acting on DNA [GO:0008094]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA negative supercoiling activity [GO:0034335]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; metal ion binding [GO:0046872] GO:0003677; GO:0003918; GO:0005524; GO:0005694; GO:0005737; GO:0005829; GO:0006261; GO:0006265; GO:0006351; GO:0008094; GO:0009330; GO:0034335; GO:0042493; GO:0046677; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01898}. +P31658 HCHA_ECOLI Protein/nucleic acid deglycase 1 (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Glyoxalase III) (EC 4.2.1.130) (Holding molecular chaperone) (Hsp31) (Maillard deglycase) hchA yedU yzzC b1967 JW1950 yedU yzzC hchA 31,190 DNA repair [GO:0006281]; guanine deglycation [GO:0106044]; methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]; protein deglycation [GO:0036525]; protein repair [GO:0030091]; response to acidic pH [GO:0010447]; response to methylglyoxal [GO:0051595]; RNA repair [GO:0042245] cytosol [GO:0005829] cytosol [GO:0005829]; glyoxalase III activity [GO:0019172]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; protein deglycase activity [GO:0036524]; thiolester hydrolase activity [GO:0016790]; zinc ion binding [GO:0008270]; DNA repair [GO:0006281]; guanine deglycation [GO:0106044]; methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]; protein deglycation [GO:0036525]; protein repair [GO:0030091]; response to acidic pH [GO:0010447]; response to methylglyoxal [GO:0051595]; RNA repair [GO:0042245] glyoxalase III activity [GO:0019172]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; protein deglycase activity [GO:0036524]; thiolester hydrolase activity [GO:0016790]; zinc ion binding [GO:0008270] GO:0005829; GO:0006281; GO:0008270; GO:0010447; GO:0016790; GO:0016811; GO:0019172; GO:0019243; GO:0030091; GO:0036524; GO:0036525; GO:0042245; GO:0051595; GO:0106044 SUBCELLULAR LOCATION: Cytoplasm. +P03960 KDPB_ECOLI Potassium-transporting ATPase ATP-binding subunit (EC 7.2.2.6) (ATP phosphohydrolase [potassium-transporting] B chain) (Potassium-binding and translocating subunit B) (Potassium-translocating ATPase B chain) kdpB b0697 JW0685 kdpB 72,199 cation transmembrane transport [GO:0098655]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; P-type potassium transmembrane transporter activity [GO:0008556]; cation transmembrane transport [GO:0098655]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; P-type potassium transmembrane transporter activity [GO:0008556] GO:0000287; GO:0005524; GO:0005886; GO:0005887; GO:0006813; GO:0008556; GO:0016021; GO:0031004; GO:0071805; GO:0098655 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00285, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2849541}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00285, ECO:0000269|PubMed:15919996}. +P76143 LSRF_ECOLI 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase (EC 2.3.1.245) lsrF yneB b1517 JW1510 yneB lsrF 31,893 cytoplasm [GO:0005737] cytoplasm [GO:0005737]; fructose-bisphosphate aldolase activity [GO:0004332]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] fructose-bisphosphate aldolase activity [GO:0004332]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] GO:0004332; GO:0005737; GO:0016747 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02052}. +P0AEI1 MIAB_ECOLI tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase (EC 2.8.4.3) ((Dimethylallyl)adenosine tRNA methylthiotransferase MiaB) (tRNA-i(6)A37 methylthiotransferase) miaB yleA b0661 JW0658 yleA miaB 53,663 tRNA methylation [GO:0030488]; tRNA methylthiolation [GO:0035600] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; methylthiotransferase activity [GO:0035596]; N6-isopentenyladenosine methylthiotransferase activity [GO:0035597]; tRNA methylation [GO:0030488]; tRNA methylthiolation [GO:0035600] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; methylthiotransferase activity [GO:0035596]; N6-isopentenyladenosine methylthiotransferase activity [GO:0035597] GO:0005829; GO:0030488; GO:0035596; GO:0035597; GO:0035600; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01864}. +P0C0S1 MSCS_ECOLI Small-conductance mechanosensitive channel mscS yggB b2924 JW2891 yggB mscS 30,896 cellular water homeostasis [GO:0009992]; ion transmembrane transport [GO:0034220]; protein homooligomerization [GO:0051260] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; identical protein binding [GO:0042802]; mechanosensitive ion channel activity [GO:0008381]; cellular water homeostasis [GO:0009992]; ion transmembrane transport [GO:0034220]; protein homooligomerization [GO:0051260] identical protein binding [GO:0042802]; mechanosensitive ion channel activity [GO:0008381] GO:0005887; GO:0008381; GO:0009992; GO:0016021; GO:0034220; GO:0042802; GO:0051260 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:10202137, ECO:0000269|PubMed:12551944, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:23012406, ECO:0000269|PubMed:23074248, ECO:0000269|PubMed:2436228, ECO:0000269|PubMed:7595939}; Multi-pass membrane protein {ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:23012406, ECO:0000269|PubMed:23339071, ECO:0000269|PubMed:26551077}. +P0AF20 NAGC_ECOLI N-acetylglucosamine repressor nagC nagR b0676 JW0662 nagR nagC 44,541 carbohydrate metabolic process [GO:0005975]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; carbohydrate metabolic process [GO:0005975]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0005975; GO:0006355 +P0AFE4 NUOK_ECOLI NADH-quinone oxidoreductase subunit K (EC 7.1.1.-) (NADH dehydrogenase I subunit K) (NDH-1 subunit K) (NUO11) nuoK b2279 JW2274 nuoK 10,845 ATP synthesis coupled electron transport [GO:0042773] integral component of plasma membrane [GO:0005887]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272] integral component of plasma membrane [GO:0005887]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038]; ATP synthesis coupled electron transport [GO:0042773] NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] GO:0005886; GO:0005887; GO:0008137; GO:0030964; GO:0042773; GO:0045272; GO:0048038 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AFD4 NUOH_ECOLI NADH-quinone oxidoreductase subunit H (EC 7.1.1.-) (NADH dehydrogenase I subunit H) (NDH-1 subunit H) (NUO8) nuoH b2282 JW2277 nuoH 36,219 aerobic respiration [GO:0009060] integral component of plasma membrane [GO:0005887]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272] integral component of plasma membrane [GO:0005887]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; quinone binding [GO:0048038]; aerobic respiration [GO:0009060] oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; quinone binding [GO:0048038] GO:0005886; GO:0005887; GO:0009060; GO:0016655; GO:0030964; GO:0045272; GO:0048038 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A784 ORN_ECOLI Oligoribonuclease (EC 3.1.-.-) orn o204a yjeR b4162 JW5740 o204a yjeR orn 20,816 RNA catabolic process [GO:0006401] cytosol [GO:0005829] cytosol [GO:0005829]; 3'-5'-exoribonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; oligoribonucleotidase activity [GO:0034611]; single-stranded DNA 3'-5' exodeoxyribonuclease activity [GO:0008310]; RNA catabolic process [GO:0006401] 3'-5'-exoribonuclease activity [GO:0000175]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; oligoribonucleotidase activity [GO:0034611]; single-stranded DNA 3'-5' exodeoxyribonuclease activity [GO:0008310] GO:0000175; GO:0003676; GO:0005829; GO:0006401; GO:0008310; GO:0034611; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P76106 HICA_ECOLI Probable mRNA interferase toxin HicA (EC 3.1.-.-) (Endoribonuclease HicA) (Toxin HicA) hicA yncN b4532 JW5230 yncN hicA 6,782 mRNA catabolic process [GO:0006402] endoribonuclease activity [GO:0004521]; mRNA binding [GO:0003729]; mRNA catabolic process [GO:0006402] endoribonuclease activity [GO:0004521]; mRNA binding [GO:0003729] GO:0003729; GO:0004521; GO:0006402 +P0A6Z1 HSCA_ECOLI Chaperone protein HscA (Hsc66) hscA hsc b2526 JW2510 hsc hscA 65,652 cellular response to cold [GO:0070417]; iron-sulfur cluster assembly [GO:0016226]; protein folding [GO:0006457]; protein maturation by iron-sulfur cluster transfer [GO:0097428] cytosol [GO:0005829]; iron-sulfur cluster transfer complex [GO:1990230] cytosol [GO:0005829]; iron-sulfur cluster transfer complex [GO:1990230]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; unfolded protein binding [GO:0051082]; cellular response to cold [GO:0070417]; iron-sulfur cluster assembly [GO:0016226]; protein folding [GO:0006457]; protein maturation by iron-sulfur cluster transfer [GO:0097428] ADP binding [GO:0043531]; ATPase activity [GO:0016887]; ATP binding [GO:0005524]; unfolded protein binding [GO:0051082] GO:0005524; GO:0005829; GO:0006457; GO:0016226; GO:0016887; GO:0043531; GO:0051082; GO:0070417; GO:0097428; GO:1990230 +P00894 ILVH_ECOLI Acetolactate synthase isozyme 3 small subunit (EC 2.2.1.6) (ALS-III) (Acetohydroxy-acid synthase III small subunit) (AHAS-III) ilvH brnP b0078 JW0077 brnP ilvH 17,977 isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] cytosol [GO:0005829] cytosol [GO:0005829]; acetolactate synthase activity [GO:0003984]; acetolactate synthase regulator activity [GO:1990610]; isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] acetolactate synthase activity [GO:0003984]; acetolactate synthase regulator activity [GO:1990610] GO:0003984; GO:0005829; GO:0009097; GO:0009099; GO:1990610 +P0AB80 ILVE_ECOLI Branched-chain-amino-acid aminotransferase (BCAT) (EC 2.6.1.42) (Transaminase B) ilvE b3770 JW5606 ilvE 34,094 aspartate biosynthetic process [GO:0006532]; carboxylic acid metabolic process [GO:0019752]; isoleucine biosynthetic process [GO:0009097]; leucine biosynthetic process [GO:0009098]; valine biosynthetic process [GO:0009099] cytosol [GO:0005829] cytosol [GO:0005829]; branched-chain-amino-acid transaminase activity [GO:0004084]; identical protein binding [GO:0042802]; L-isoleucine transaminase activity [GO:0052656]; L-leucine transaminase activity [GO:0052654]; L-leucine:2-oxoglutarate aminotransferase activity [GO:0050048]; L-valine transaminase activity [GO:0052655]; aspartate biosynthetic process [GO:0006532]; carboxylic acid metabolic process [GO:0019752]; isoleucine biosynthetic process [GO:0009097]; leucine biosynthetic process [GO:0009098]; valine biosynthetic process [GO:0009099] branched-chain-amino-acid transaminase activity [GO:0004084]; identical protein binding [GO:0042802]; L-isoleucine transaminase activity [GO:0052656]; L-leucine:2-oxoglutarate aminotransferase activity [GO:0050048]; L-leucine transaminase activity [GO:0052654]; L-valine transaminase activity [GO:0052655] GO:0004084; GO:0005829; GO:0006532; GO:0009097; GO:0009098; GO:0009099; GO:0019752; GO:0042802; GO:0050048; GO:0052654; GO:0052655; GO:0052656 +P21517 MALZ_ECOLI Maltodextrin glucosidase (EC 3.2.1.20) (Alpha-glucosidase) malZ b0403 JW0393 malZ 69,041 alpha-glucan catabolic process [GO:0030980]; cellular oligosaccharide catabolic process [GO:0051692] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; alpha-1,4-glucosidase activity [GO:0004558]; maltose alpha-glucosidase activity [GO:0032450]; alpha-glucan catabolic process [GO:0030980]; cellular oligosaccharide catabolic process [GO:0051692] alpha-1,4-glucosidase activity [GO:0004558]; maltose alpha-glucosidase activity [GO:0032450] GO:0004558; GO:0005737; GO:0030980; GO:0032450; GO:0051692 SUBCELLULAR LOCATION: Cytoplasm. +P69222 IF1_ECOLI Translation initiation factor IF-1 infA b0884 JW0867 infA 8,250 cytosol [GO:0005829] cytosol [GO:0005829]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843]; translation initiation factor activity [GO:0003743] ribosome binding [GO:0043022]; rRNA binding [GO:0019843]; translation initiation factor activity [GO:0003743] GO:0003743; GO:0005829; GO:0019843; GO:0043022 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00075, ECO:0000269|PubMed:376343}. +C1P619 ILVX_ECOLI Uncharacterized protein IlvX ilvX b4669 JW3740.1 ilvX 1,910 +P0ADE6 KBP_ECOLI Potassium binding protein Kbp (K(+) binding protein Kbp) kbp ygaU yzzM b2665 JW2640 ygaU yzzM kbp 16,063 response to potassium ion [GO:0035864] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; potassium ion binding [GO:0030955]; response to potassium ion [GO:0035864] potassium ion binding [GO:0030955] GO:0005737; GO:0030955; GO:0035864 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:27112601}. +P0AFS9 MEPM_ECOLI Murein DD-endopeptidase MepM (EC 3.4.24.-) (Murein hydrolase MepM) (ORFU) mepM yebA b1856 JW5304 yebA mepM 49,058 capsule polysaccharide biosynthetic process [GO:0045227]; cell wall organization [GO:0071555]; peptidoglycan metabolic process [GO:0000270]; peptidoglycan turnover [GO:0009254]; septum digestion after cytokinesis [GO:0000920] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; capsule polysaccharide biosynthetic process [GO:0045227]; cell wall organization [GO:0071555]; peptidoglycan metabolic process [GO:0000270]; peptidoglycan turnover [GO:0009254]; septum digestion after cytokinesis [GO:0000920] endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] GO:0000270; GO:0000920; GO:0004175; GO:0004222; GO:0005886; GO:0009254; GO:0016021; GO:0045227; GO:0046872; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Uniform peripheral location, with partial enrichment at cell poles. +P50456 MLC_ECOLI Protein mlc (Making large colonies protein) mlc b1594 JW1586 mlc 44,316 carbohydrate metabolic process [GO:0005975]; transcription, DNA-templated [GO:0006351] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; carbohydrate metabolic process [GO:0005975]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] GO:0003677; GO:0005737; GO:0005975; GO:0006351; GO:0042802; GO:0046872 +P25738 MSYB_ECOLI Acidic protein MsyB msyB b1051 JW1039 msyB 14,259 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +Q46877 NORV_ECOLI Anaerobic nitric oxide reductase flavorubredoxin (FlRd) (FlavoRb) norV flrD ygaI ygaJ ygaK b2710 JW2680 flrD ygaI ygaJ ygaK norV 54,234 nitric oxide catabolic process [GO:0046210]; response to nitric oxide [GO:0071731] cytoplasm [GO:0005737]; protein-containing complex [GO:0032991] cytoplasm [GO:0005737]; protein-containing complex [GO:0032991]; electron transfer activity [GO:0009055]; FMN binding [GO:0010181]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; nitric oxide reductase activity [GO:0016966]; oxidoreductase activity, acting on other nitrogenous compounds as donors [GO:0016661]; nitric oxide catabolic process [GO:0046210]; response to nitric oxide [GO:0071731] electron transfer activity [GO:0009055]; FMN binding [GO:0010181]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; nitric oxide reductase activity [GO:0016966]; oxidoreductase activity, acting on other nitrogenous compounds as donors [GO:0016661] GO:0005506; GO:0005737; GO:0009055; GO:0010181; GO:0016661; GO:0016966; GO:0032991; GO:0042802; GO:0046210; GO:0071731 SUBCELLULAR LOCATION: Cytoplasm. +P00935 METB_ECOLI Cystathionine gamma-synthase (CGS) (EC 2.5.1.48) (O-succinylhomoserine (thiol)-lyase) metB b3939 JW3910 metB 41,550 cysteine biosynthetic process via cystathionine [GO:0019343]; methionine biosynthetic process [GO:0009086]; transsulfuration [GO:0019346] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; carbon-sulfur lyase activity [GO:0016846]; cystathionine gamma-lyase activity [GO:0004123]; cystathionine gamma-synthase activity [GO:0003962]; cystathionine gamma-synthase activity (acts on O-phosphohomoserine) [GO:0102028]; pyridoxal phosphate binding [GO:0030170]; cysteine biosynthetic process via cystathionine [GO:0019343]; methionine biosynthetic process [GO:0009086]; transsulfuration [GO:0019346] carbon-sulfur lyase activity [GO:0016846]; cystathionine gamma-lyase activity [GO:0004123]; cystathionine gamma-synthase activity [GO:0003962]; cystathionine gamma-synthase activity (acts on O-phosphohomoserine) [GO:0102028]; pyridoxal phosphate binding [GO:0030170] GO:0003962; GO:0004123; GO:0005737; GO:0009086; GO:0016846; GO:0019343; GO:0019346; GO:0030170; GO:0102028 SUBCELLULAR LOCATION: Cytoplasm. +P16926 MREC_ECOLI Cell shape-determining protein MreC (Cell shape protein MreC) (Rod shape-determining protein MreC) mreC b3250 JW3219 mreC 39,530 establishment or maintenance of cell polarity regulating cell shape [GO:0071963]; regulation of cell shape [GO:0008360] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; protein self-association [GO:0043621]; establishment or maintenance of cell polarity regulating cell shape [GO:0071963]; regulation of cell shape [GO:0008360] protein self-association [GO:0043621] GO:0005886; GO:0005887; GO:0008360; GO:0043621; GO:0071963 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15612918}; Single-pass membrane protein {ECO:0000269|PubMed:15612918}. +P23909 MUTS_ECOLI DNA mismatch repair protein MutS mutS fdv b2733 JW2703 fdv mutS 95,247 cellular response to DNA damage stimulus [GO:0006974]; mismatch repair [GO:0006298]; regulation of DNA recombination [GO:0000018] cytosol [GO:0005829]; mismatch repair complex [GO:0032300] cytosol [GO:0005829]; mismatch repair complex [GO:0032300]; adenine/cytosine mispair binding [GO:0032136]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase activity, acting on DNA [GO:0008094]; damaged DNA binding [GO:0003684]; DNA binding, bending [GO:0008301]; identical protein binding [GO:0042802]; mismatched DNA binding [GO:0030983]; cellular response to DNA damage stimulus [GO:0006974]; mismatch repair [GO:0006298]; regulation of DNA recombination [GO:0000018] adenine/cytosine mispair binding [GO:0032136]; ADP binding [GO:0043531]; ATPase activity [GO:0016887]; ATPase activity, acting on DNA [GO:0008094]; ATP binding [GO:0005524]; damaged DNA binding [GO:0003684]; DNA binding, bending [GO:0008301]; identical protein binding [GO:0042802]; mismatched DNA binding [GO:0030983] GO:0000018; GO:0003684; GO:0005524; GO:0005829; GO:0006298; GO:0006974; GO:0008094; GO:0008301; GO:0016887; GO:0030983; GO:0032136; GO:0032300; GO:0042802; GO:0043531 +P0ABL1 NRFB_ECOLI Cytochrome c-type protein NrfB nrfB yjcI b4071 JW4032 yjcI nrfB 20,714 anaerobic electron transport chain [GO:0019645]; nitrogen compound metabolic process [GO:0006807] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; nitrite reductase (cytochrome, ammonia-forming) activity [GO:0042279]; oxidoreductase activity [GO:0016491]; anaerobic electron transport chain [GO:0019645]; nitrogen compound metabolic process [GO:0006807] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; nitrite reductase (cytochrome, ammonia-forming) activity [GO:0042279]; oxidoreductase activity [GO:0016491] GO:0006807; GO:0009055; GO:0016491; GO:0019645; GO:0020037; GO:0030288; GO:0042279; GO:0046872 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P76773 OMPL_ECOLI Porin OmpL ompL yshA b3875 JW3846 yshA ompL 27,200 arabinose transmembrane transport [GO:0015751]; galactose transmembrane transport [GO:0015757]; glucose import [GO:0046323]; oligosaccharide transport [GO:0015772] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; pore complex [GO:0046930]; porin activity [GO:0015288]; arabinose transmembrane transport [GO:0015751]; galactose transmembrane transport [GO:0015757]; glucose import [GO:0046323]; oligosaccharide transport [GO:0015772] porin activity [GO:0015288] GO:0009279; GO:0015288; GO:0015751; GO:0015757; GO:0015772; GO:0045203; GO:0046323; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:11080145}. +P08400 PHOR_ECOLI Phosphate regulon sensor protein PhoR (EC 2.7.13.3) phoR nmpB b0400 JW0390 nmpB phoR 49,629 cellular response to phosphate starvation [GO:0016036]; peptidyl-histidine phosphorylation [GO:0018106]; phosphate ion transport [GO:0006817]; protein autophosphorylation [GO:0046777]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155]; cellular response to phosphate starvation [GO:0016036]; peptidyl-histidine phosphorylation [GO:0018106]; phosphate ion transport [GO:0006817]; protein autophosphorylation [GO:0046777]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165] ATP binding [GO:0005524]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155] GO:0000155; GO:0004721; GO:0005524; GO:0005829; GO:0005886; GO:0005887; GO:0006355; GO:0006817; GO:0007165; GO:0016021; GO:0016036; GO:0018106; GO:0046777 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:2187152}; Multi-pass membrane protein {ECO:0000269|PubMed:2187152}. +P67080 PLPHP_ECOLI Pyridoxal phosphate homeostasis protein (PLP homeostasis protein) yggS b2951 JW2918 yggS 25,787 cytosol [GO:0005829] cytosol [GO:0005829]; pyridoxal phosphate binding [GO:0030170] pyridoxal phosphate binding [GO:0030170] GO:0005829; GO:0030170 +P08839 PT1_ECOLI Phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) (Phosphotransferase system, enzyme I) ptsI b2416 JW2409 ptsI 63,562 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytosol [GO:0005829]; phosphoenolpyruvate-dependent sugar phosphotransferase complex [GO:0019197] cytosol [GO:0005829]; phosphoenolpyruvate-dependent sugar phosphotransferase complex [GO:0019197]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; phosphoenolpyruvate-protein phosphotransferase activity [GO:0008965]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; phosphoenolpyruvate-protein phosphotransferase activity [GO:0008965] GO:0000287; GO:0005829; GO:0008965; GO:0009401; GO:0016301; GO:0019197; GO:0042802; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P41441 GSPF_ECOLI Putative type II secretion system protein F (T2SS protein F) (General secretion pathway protein F) (Protein transport protein HofF) gspF hofF hopF b3327 JW3289 hofF hopF gspF 44,339 protein secretion by the type II secretion system [GO:0015628] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627]; metal ion binding [GO:0046872]; protein secretion by the type II secretion system [GO:0015628] metal ion binding [GO:0046872] GO:0005886; GO:0015627; GO:0015628; GO:0016021; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AES9 HDEA_ECOLI Acid stress chaperone HdeA (10K-S protein) hdeA yhhC yhiB b3510 JW3478 yhhC yhiB hdeA 11,858 cellular response to acidic pH [GO:0071468]; cellular stress response to acidic pH [GO:1990451] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; chaperone binding [GO:0051087]; identical protein binding [GO:0042802]; cellular response to acidic pH [GO:0071468]; cellular stress response to acidic pH [GO:1990451] chaperone binding [GO:0051087]; identical protein binding [GO:0042802] GO:0030288; GO:0042802; GO:0051087; GO:0071468; GO:1990451 SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00946, ECO:0000269|PubMed:17085547}. +P16528 ICLR_ECOLI Transcriptional repressor IclR (Acetate operon repressor) iclR b4018 JW3978 iclR 29,739 glyoxylate cycle [GO:0006097]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; glyoxylate cycle [GO:0006097]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0005829; GO:0006097; GO:0006355; GO:0045892 +P0CE58 INH11_ECOLI Transposase InsH for insertion sequence element IS5T insH11 b3505 JW3472 insH11 37,851 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0A917 OMPX_ECOLI Outer membrane protein X ompX ybiG b0814 JW0799 ybiG ompX 18,603 cell outer membrane [GO:0009279]; host outer membrane [GO:0044384]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; host outer membrane [GO:0044384]; integral component of membrane [GO:0016021] GO:0009279; GO:0016021; GO:0044384 SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein. +P0ABW0 HCAC_ECOLI 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit hcaC hcaA3 phdB yfhW b2540 JW2524 hcaA3 phdB yfhW hcaC 11,329 3-phenylpropionate catabolic process [GO:0019380] 2 iron, 2 sulfur cluster binding [GO:0051537]; 3-phenylpropionate dioxygenase activity [GO:0008695]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; 3-phenylpropionate catabolic process [GO:0019380] 2 iron, 2 sulfur cluster binding [GO:0051537]; 3-phenylpropionate dioxygenase activity [GO:0008695]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872] GO:0008695; GO:0019380; GO:0046872; GO:0051536; GO:0051537 +Q47140 HCAF_ECOLI 3-phenylpropionate/cinnamic acid dioxygenase subunit beta (EC 1.14.12.19) hcaF digB hcaA2 hcaB phdC2 yfhV b2539 JW2523 digB hcaA2 hcaB phdC2 yfhV hcaF 20,579 3-phenylpropionate catabolic process [GO:0019380] 3-phenylpropionate dioxygenase activity [GO:0008695]; 3-phenylpropionate catabolic process [GO:0019380] 3-phenylpropionate dioxygenase activity [GO:0008695] GO:0008695; GO:0019380 +P46118 HEXR_ECOLI HTH-type transcriptional regulator HexR (Hex regulon repressor) hexR yebK b1853 JW1842 yebK hexR 31,976 carbohydrate derivative metabolic process [GO:1901135]; cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355] carbohydrate derivative binding [GO:0097367]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; carbohydrate derivative metabolic process [GO:1901135]; cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355] carbohydrate derivative binding [GO:0097367]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006355; GO:0006974; GO:0097367; GO:1901135 +P0A756 KEFG_ECOLI Glutathione-regulated potassium-efflux system ancillary protein KefG (Putative quinone oxidoreductase KefG) (EC 1.6.5.2) kefG yheR b3351 JW3314 yheR kefG 20,958 positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transport [GO:0006813] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; FMN binding [GO:0010181]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; NADH dehydrogenase (quinone) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transport [GO:0006813] electron transfer activity [GO:0009055]; FMN binding [GO:0010181]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; NADH dehydrogenase (quinone) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753] GO:0003955; GO:0005886; GO:0006813; GO:0008753; GO:0009055; GO:0010181; GO:0032414; GO:0050136; GO:1901381 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01415}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01415}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_01415}. +P15005 MCRB_ECOLI 5-methylcytosine-specific restriction enzyme B (EC 3.1.21.-) (EcoKMcrBC) mcrB rglB b4346 JW5871 rglB mcrB 53,157 DNA catabolic process [GO:0006308]; DNA restriction-modification system [GO:0009307] ATP binding [GO:0005524]; ATPase activity [GO:0016887]; DNA binding [GO:0003677]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; restriction endodeoxyribonuclease activity [GO:0015666]; DNA catabolic process [GO:0006308]; DNA restriction-modification system [GO:0009307] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; restriction endodeoxyribonuclease activity [GO:0015666] GO:0003677; GO:0003924; GO:0005524; GO:0005525; GO:0006308; GO:0009307; GO:0015666; GO:0016887; GO:0042802 +P22188 MURE_ECOLI UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) (Meso-A2pm-adding enzyme) (Meso-diaminopimelate-adding enzyme) (UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase) (UDP-MurNAc-tripeptide synthetase) (UDP-N-acetylmuramyl-tripeptide synthetase) murE b0085 JW0083 murE 53,344 cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity [GO:0008765]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity [GO:0008765] GO:0000287; GO:0005524; GO:0005829; GO:0007049; GO:0008360; GO:0008765; GO:0009252; GO:0051301; GO:0071555 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AEI6 NUDJ_ECOLI Phosphatase NudJ (EC 3.6.1.-) nudJ ymfB b1134 JW1120 ymfB nudJ 17,433 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity [GO:0002145]; nucleoside-diphosphatase activity [GO:0017110]; nucleoside-triphosphatase activity [GO:0017111]; pyrophosphatase activity [GO:0016462]; thiamine-diphosphatase activity [GO:0004787] 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity [GO:0002145]; nucleoside-diphosphatase activity [GO:0017110]; nucleoside-triphosphatase activity [GO:0017111]; pyrophosphatase activity [GO:0016462]; thiamine-diphosphatase activity [GO:0004787] GO:0002145; GO:0004787; GO:0016462; GO:0017110; GO:0017111 +P04391 OTC1_ECOLI Ornithine carbamoyltransferase subunit I (OTCase-1) (EC 2.1.3.3) argI b4254 JW4211 argI 36,907 arginine biosynthetic process via ornithine [GO:0042450]; citrulline biosynthetic process [GO:0019240] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; amino acid binding [GO:0016597]; metal ion binding [GO:0046872]; ornithine carbamoyltransferase activity [GO:0004585]; arginine biosynthetic process via ornithine [GO:0042450]; citrulline biosynthetic process [GO:0019240] amino acid binding [GO:0016597]; metal ion binding [GO:0046872]; ornithine carbamoyltransferase activity [GO:0004585] GO:0004585; GO:0005737; GO:0016597; GO:0019240; GO:0042450; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A780 NUSB_ECOLI Transcription antitermination protein NusB (Antitermination factor NusB) (N utilization substance protein B) nusB groNB ssyB b0416 JW0406 groNB ssyB nusB 15,689 DNA-templated transcription, termination [GO:0006353]; regulation of transcription, DNA-templated [GO:0006355]; ribosome biogenesis [GO:0042254]; transcription antitermination [GO:0031564] cytosol [GO:0005829] cytosol [GO:0005829]; RNA binding [GO:0003723]; DNA-templated transcription, termination [GO:0006353]; regulation of transcription, DNA-templated [GO:0006355]; ribosome biogenesis [GO:0042254]; transcription antitermination [GO:0031564] RNA binding [GO:0003723] GO:0003723; GO:0005829; GO:0006353; GO:0006355; GO:0031564; GO:0042254 +P69434 PGAA_ECOLI Poly-beta-1,6-N-acetyl-D-glucosamine export protein (PGA export protein) (Poly-beta-1,6-GlcNAc export protein) pgaA ycdS b1024 JW1010 ycdS pgaA 92,207 polysaccharide transport [GO:0015774] integral component of cell outer membrane [GO:0045203] integral component of cell outer membrane [GO:0045203]; poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity [GO:1901515]; polysaccharide transmembrane transporter activity [GO:0015159]; polysaccharide transport [GO:0015774] poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity [GO:1901515]; polysaccharide transmembrane transporter activity [GO:0015159] GO:0015159; GO:0015774; GO:0045203; GO:1901515 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305|PubMed:18359807}; Multi-pass membrane protein {ECO:0000305|PubMed:18359807}. +P0ABR5 HCAE_ECOLI 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha (EC 1.14.12.19) hcaE digA hcaA hcaA1 phdC1 yfhU b2538 JW2522 digA hcaA hcaA1 phdC1 yfhU hcaE 51,109 3-phenylpropionate catabolic process [GO:0019380] 2 iron, 2 sulfur cluster binding [GO:0051537]; 3-phenylpropionate dioxygenase activity [GO:0008695]; iron ion binding [GO:0005506]; 3-phenylpropionate catabolic process [GO:0019380] 2 iron, 2 sulfur cluster binding [GO:0051537]; 3-phenylpropionate dioxygenase activity [GO:0008695]; iron ion binding [GO:0005506] GO:0005506; GO:0008695; GO:0019380; GO:0051537 +P0ACE7 HINT_ECOLI Purine nucleoside phosphoramidase (EC 3.9.1.-) (Histidine triad nucleotide binding protein HinT) (HIT protein) hinT ycfF b1103 JW1089 ycfF hinT 13,241 D-alanine catabolic process [GO:0055130] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; adenosine 5'-monophosphoramidase activity [GO:0043530]; hydrolase activity [GO:0016787]; nucleotide binding [GO:0000166]; D-alanine catabolic process [GO:0055130] adenosine 5'-monophosphoramidase activity [GO:0043530]; hydrolase activity [GO:0016787]; nucleotide binding [GO:0000166] GO:0000166; GO:0005737; GO:0005829; GO:0016787; GO:0043530; GO:0055130 +P67910 HLDD_ECOLI ADP-L-glycero-D-manno-heptose-6-epimerase (EC 5.1.3.20) (ADP-L-glycero-beta-D-manno-heptose-6-epimerase) (ADP-glyceromanno-heptose 6-epimerase) (ADP-hep 6-epimerase) (AGME) hldD htrM rfaD waaD b3619 JW3594 htrM rfaD waaD hldD 34,893 ADP-L-glycero-beta-D-manno-heptose biosynthetic process [GO:0097171]; lipopolysaccharide core region biosynthetic process [GO:0009244] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; ADP-glyceromanno-heptose 6-epimerase activity [GO:0008712]; NADP+ binding [GO:0070401]; ADP-L-glycero-beta-D-manno-heptose biosynthetic process [GO:0097171]; lipopolysaccharide core region biosynthetic process [GO:0009244] ADP-glyceromanno-heptose 6-epimerase activity [GO:0008712]; NADP+ binding [GO:0070401] GO:0005829; GO:0008712; GO:0009244; GO:0016020; GO:0070401; GO:0097171 +P77091 HOKE_ECOLI Toxic protein HokE hokE ybdY b4415 JW5084 ybdY hokE 5,564 cellular response to DNA damage stimulus [GO:0006974] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cellular response to DNA damage stimulus [GO:0006974] GO:0005886; GO:0006974; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:P0ACG4}; Single-pass membrane protein {ECO:0000250|UniProtKB:P0ACG4}. +P75969 INTE_ECOLI Prophage integrase IntE (Int(Lambda)) (Prophage e14 integrase) (Prophage lambda integrase) intE ycfI b1140 JW1126 ycfI intE 42,799 DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA binding [GO:0003677]; integrase activity [GO:0008907]; protein heterodimerization activity [GO:0046982]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA binding [GO:0003677]; integrase activity [GO:0008907]; protein heterodimerization activity [GO:0046982] GO:0003677; GO:0006310; GO:0008907; GO:0044826; GO:0046718; GO:0046982; GO:0075713 +P0CF26 INSB2_ECOLI Insertion element IS1 2 protein InsB (IS1b) insB2 b0264 JW0256 insB2 19,758 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CF40 INSC1_ECOLI Transposase InsC for insertion element IS2A insC1 b0360 JW0351 insC1 13,452 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CF41 INSC2_ECOLI Transposase InsC for insertion element IS2D insC2 b1403 JW1400 insC2 13,452 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CF54 INSD2_ECOLI Transposase InsD for insertion element IS2D insD2 b1402 JW1397 insD2 34,398 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0032196 +P45464 LPOA_ECOLI Penicillin-binding protein activator LpoA (PBP activator LpoA) (Lipoprotein activator of PBP from the outer membrane A) lpoA yraM b3147 JW3116 yraM lpoA 72,825 peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] cell outer membrane [GO:0009279]; periplasmic side of cell outer membrane [GO:0031241]; periplasmic space [GO:0042597] cell outer membrane [GO:0009279]; periplasmic side of cell outer membrane [GO:0031241]; periplasmic space [GO:0042597]; enzyme regulator activity [GO:0030234]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] enzyme regulator activity [GO:0030234]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553] GO:0004553; GO:0008360; GO:0009252; GO:0009279; GO:0030234; GO:0031241; GO:0042597 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:21183073, ECO:0000269|PubMed:21183074}; Lipid-anchor {ECO:0000269|PubMed:21183073, ECO:0000269|PubMed:21183074}; Periplasmic side {ECO:0000269|PubMed:21183073, ECO:0000269|PubMed:21183074}. Note=Localizes at the sidewall of elongating cells. +P76594 LYSAC_ECOLI Peptidyl-lysine N-acetyltransferase PatZ (EC 2.3.1.-) (Protein lysine acetyltransferase) patZ pka yfiQ b2584 JW2568 pka yfiQ patZ 97,987 internal peptidyl-lysine acetylation [GO:0018393]; regulation of protein homooligomerization [GO:0032462]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; peptidyl-lysine acetyltransferase activity [GO:0052858]; internal peptidyl-lysine acetylation [GO:0018393]; regulation of protein homooligomerization [GO:0032462]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; peptidyl-lysine acetyltransferase activity [GO:0052858] GO:0005524; GO:0006979; GO:0009408; GO:0018393; GO:0032462; GO:0032991; GO:0042802; GO:0046872; GO:0052858; GO:0061733 +P60293 MUKF_ECOLI Chromosome partition protein MukF (Protein KicB) mukF kicB b0922 JW0905 kicB mukF 50,579 cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome condensation [GO:0030261]; chromosome segregation [GO:0007059]; DNA replication [GO:0006260] cytoplasm [GO:0005737]; nucleoid [GO:0009295] cytoplasm [GO:0005737]; nucleoid [GO:0009295]; calcium ion binding [GO:0005509]; cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome condensation [GO:0030261]; chromosome segregation [GO:0007059]; DNA replication [GO:0006260] calcium ion binding [GO:0005509] GO:0005509; GO:0005737; GO:0006260; GO:0007049; GO:0007059; GO:0009295; GO:0030261; GO:0051301 SUBCELLULAR LOCATION: Cytoplasm, nucleoid. Note=Restricted to the nucleoid region. +P75798 GSIC_ECOLI Glutathione transport system permease protein GsiC gsiC yliC b0831 JW0815 yliC gsiC 34,066 glutathione transmembrane transport [GO:0034775] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; glutathione transmembrane transporter activity [GO:0034634]; glutathione transmembrane transport [GO:0034775] glutathione transmembrane transporter activity [GO:0034634] GO:0005886; GO:0005887; GO:0034634; GO:0034775 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P25960 LEP4_ECOLI Prepilin leader peptidase/N-methyltransferase [Includes: Leader peptidase (EC 3.4.23.43) (Prepilin peptidase); N-methyltransferase (EC 2.1.1.-)] gspO hofD hopD hopO yheC b3335 JW3297 hofD hopD hopO yheC gspO 24,957 signal peptide processing [GO:0006465] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; aspartic-type endopeptidase activity [GO:0004190]; transferase activity [GO:0016740]; signal peptide processing [GO:0006465] aspartic-type endopeptidase activity [GO:0004190]; transferase activity [GO:0016740] GO:0004190; GO:0005886; GO:0006465; GO:0016021; GO:0016740 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:P22610}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P22610}. +P36771 LRHA_ECOLI Probable HTH-type transcriptional regulator LrhA lrhA genR b2289 JW2284 genR lrhA 34,594 negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0000986; GO:0003700; GO:0006351; GO:0006355; GO:0043565; GO:0045892; GO:0045893 +P0A725 LPXC_ECOLI UDP-3-O-acyl-N-acetylglucosamine deacetylase (UDP-3-O-acyl-GlcNAc deacetylase) (EC 3.5.1.108) (Protein EnvA) (UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase) lpxC asmB envA b0096 JW0094 asmB envA lpxC 33,956 lipid A biosynthetic process [GO:0009245] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; deacetylase activity [GO:0019213]; iron ion binding [GO:0005506]; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity [GO:0008759]; UDP-3-O-acyl-N-acetylglucosamine deacetylase activity [GO:0103117]; zinc ion binding [GO:0008270]; lipid A biosynthetic process [GO:0009245] deacetylase activity [GO:0019213]; iron ion binding [GO:0005506]; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity [GO:0008759]; UDP-3-O-acyl-N-acetylglucosamine deacetylase activity [GO:0103117]; zinc ion binding [GO:0008270] GO:0005506; GO:0005737; GO:0008270; GO:0008759; GO:0009245; GO:0019213; GO:0103117 +P0AFS1 LSRD_ECOLI Autoinducer 2 import system permease protein LsrD (AI-2 import system permease protein LsrD) lsrD ydeZ b1515 JW1508 ydeZ lsrD 34,456 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A9S7 LIVG_ECOLI High-affinity branched-chain amino acid transport ATP-binding protein LivG (LIV-I protein G) livG b3455 JW3420 livG 28,427 branched-chain amino acid transport [GO:0015803]; D-alanine transport [GO:0042941]; isoleucine transmembrane transport [GO:1903714]; L-alanine transport [GO:0015808]; leucine import across plasma membrane [GO:0098713]; L-isoleucine import across plasma membrane [GO:1903806]; L-valine import across plasma membrane [GO:1903805]; L-valine transmembrane transport [GO:1903785]; phenylalanine transport [GO:0015823] membrane [GO:0016020]; plasma membrane [GO:0005886] membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; branched-chain amino acid transmembrane transporter activity [GO:0015658]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-leucine transmembrane transporter activity [GO:0015190]; L-phenylalanine transmembrane transporter activity [GO:0015192]; L-valine transmembrane transporter activity [GO:0005304]; branched-chain amino acid transport [GO:0015803]; D-alanine transport [GO:0042941]; isoleucine transmembrane transport [GO:1903714]; L-alanine transport [GO:0015808]; L-isoleucine import across plasma membrane [GO:1903806]; L-valine import across plasma membrane [GO:1903805]; L-valine transmembrane transport [GO:1903785]; leucine import across plasma membrane [GO:0098713]; phenylalanine transport [GO:0015823] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; branched-chain amino acid transmembrane transporter activity [GO:0015658]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-leucine transmembrane transporter activity [GO:0015190]; L-phenylalanine transmembrane transporter activity [GO:0015192]; L-valine transmembrane transporter activity [GO:0005304] GO:0005304; GO:0005524; GO:0005886; GO:0015188; GO:0015190; GO:0015192; GO:0015658; GO:0015803; GO:0015808; GO:0015823; GO:0016020; GO:0042626; GO:0042941; GO:0098713; GO:1903714; GO:1903785; GO:1903805; GO:1903806 +P76142 LSRB_ECOLI Autoinducer 2-binding protein LsrB (AI-2-binding protein LsrB) lsrB yneA b1516 JW1509 yneA lsrB 36,685 ATP-binding cassette (ABC) transporter complex [GO:0043190]; periplasmic space [GO:0042597] ATP-binding cassette (ABC) transporter complex [GO:0043190]; periplasmic space [GO:0042597] GO:0042597; GO:0043190 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P04816 LIVK_ECOLI Leucine-specific-binding protein (L-BP) (LS-BP) livK b3458 JW3423 livK 39,379 leucine transport [GO:0015820] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; leucine binding [GO:0070728]; leucine transport [GO:0015820] leucine binding [GO:0070728] GO:0015820; GO:0030288; GO:0070728 SUBCELLULAR LOCATION: Periplasm. +P25737 LYSP_ECOLI Lysine-specific permease lysP cadR b2156 JW2143 cadR lysP 53,576 amino acid transmembrane transport [GO:0003333]; L-lysine import across plasma membrane [GO:0097639]; regulation of DNA-binding transcription factor activity [GO:0051090]; response to amino acid [GO:0043200] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; identical protein binding [GO:0042802]; L-lysine transmembrane transporter activity [GO:0015189]; transcription factor binding [GO:0008134]; amino acid transmembrane transport [GO:0003333]; L-lysine import across plasma membrane [GO:0097639]; regulation of DNA-binding transcription factor activity [GO:0051090]; response to amino acid [GO:0043200] amino acid transmembrane transporter activity [GO:0015171]; identical protein binding [GO:0042802]; L-lysine transmembrane transporter activity [GO:0015189]; transcription factor binding [GO:0008134] GO:0003333; GO:0005886; GO:0005887; GO:0008134; GO:0015171; GO:0015189; GO:0016021; GO:0042802; GO:0043200; GO:0051090; GO:0097639 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P00393 NDH_ECOLI Type II NADH:quinone oxidoreductase (EC 1.6.5.9) (Cupric reductase) (EC 1.16.1.-) (NADH dehydrogenase-2) (NADH dh II) (NDH-2) (NADH-quinone reductase) (NQR) (NADH:ubiquinone oxidoreductase) (Respiratory NADH dehydrogenase) ndh b1109 JW1095 ndh 47,359 aerobic electron transport chain [GO:0019646]; aerobic respiration [GO:0009060]; anaerobic respiration [GO:0009061]; copper ion homeostasis [GO:0055070] NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886] NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; flavin adenine dinucleotide binding [GO:0050660]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; aerobic electron transport chain [GO:0019646]; aerobic respiration [GO:0009060]; anaerobic respiration [GO:0009061]; copper ion homeostasis [GO:0055070] flavin adenine dinucleotide binding [GO:0050660]; NADH dehydrogenase (ubiquinone) activity [GO:0008137] GO:0005886; GO:0008137; GO:0009060; GO:0009061; GO:0019646; GO:0030964; GO:0050660; GO:0055070 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:10664466, ECO:0000269|PubMed:2679883, ECO:0000269|PubMed:6362717, ECO:0000269|PubMed:6784762, ECO:0000269|PubMed:7009604, ECO:0000269|PubMed:7020757}; Peripheral membrane protein {ECO:0000269|PubMed:10664466, ECO:0000305|PubMed:12176061}; Cytoplasmic side {ECO:0000305|PubMed:12176061}. Note=Membrane-bound (PubMed:10664466). Interaction with the membrane is probably mediated by amphipathic helices and electrostatic interactions (PubMed:15581635). Copurifies with phospholipids (PubMed:7020757, PubMed:6362717). {ECO:0000269|PubMed:10664466, ECO:0000269|PubMed:15581635, ECO:0000269|PubMed:6362717, ECO:0000269|PubMed:7020757}. +P07018 MCP4_ECOLI Methyl-accepting chemotaxis protein IV (MCP-IV) (Dipeptide chemoreceptor protein) tap b1885 JW1874 tap 57,512 chemotaxis [GO:0006935]; signal transduction [GO:0007165] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; chemotaxis [GO:0006935]; signal transduction [GO:0007165] transmembrane signaling receptor activity [GO:0004888] GO:0004888; GO:0005886; GO:0005887; GO:0006935; GO:0007165 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:22380631}; Multi-pass membrane protein {ECO:0000269|PubMed:22380631}. Note=Found predominantly at cell poles. +P31121 MARB_ECOLI Multiple antibiotic resistance protein MarB marB b1532 JW1525 marB 7,537 response to antibiotic [GO:0046677] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; response to antibiotic [GO:0046677] GO:0030288; GO:0046677 +P0AEY1 MARC_ECOLI UPF0056 inner membrane protein MarC marC ydeB ydeC b1529 JW1522 ydeB ydeC marC 23,617 integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887] GO:0005887 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AF12 MTNN_ECOLI 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTA/SAH nucleosidase) (MTAN) (EC 3.2.2.9) (5'-deoxyadenosine nucleosidase) (DOA nucleosidase) (dAdo nucleosidase) (5'-methylthioadenosine nucleosidase) (MTA nucleosidase) (S-adenosylhomocysteine nucleosidase) (AdoHcy nucleosidase) (SAH nucleosidase) (SRH nucleosidase) mtnN mtn pfs yadA b0159 JW0155 mtn pfs yadA mtnN 24,354 L-methionine salvage from methylthioadenosine [GO:0019509]; L-methionine salvage from S-adenosylmethionine [GO:0019284]; purine deoxyribonucleoside catabolic process [GO:0046124]; toxic metabolite repair [GO:0110052] cytosol [GO:0005829] cytosol [GO:0005829]; adenosylhomocysteine nucleosidase activity [GO:0008782]; identical protein binding [GO:0042802]; methylthioadenosine nucleosidase activity [GO:0008930]; L-methionine salvage from methylthioadenosine [GO:0019509]; L-methionine salvage from S-adenosylmethionine [GO:0019284]; purine deoxyribonucleoside catabolic process [GO:0046124]; toxic metabolite repair [GO:0110052] adenosylhomocysteine nucleosidase activity [GO:0008782]; identical protein binding [GO:0042802]; methylthioadenosine nucleosidase activity [GO:0008930] GO:0005829; GO:0008782; GO:0008930; GO:0019284; GO:0019509; GO:0042802; GO:0046124; GO:0110052 +P0A8D0 NRDR_ECOLI Transcriptional repressor NrdR nrdR ybaD b0413 JW0403 ybaD nrdR 17,229 negative regulation of transcription, DNA-templated [GO:0045892] ATP binding [GO:0005524]; double-stranded DNA binding [GO:0003690]; zinc ion binding [GO:0008270]; negative regulation of transcription, DNA-templated [GO:0045892] ATP binding [GO:0005524]; double-stranded DNA binding [GO:0003690]; zinc ion binding [GO:0008270] GO:0003690; GO:0005524; GO:0008270; GO:0045892 +E2JKY7 LPMG_ECOLI mgtA leader peptide (Regulatory leader peptide for mgtA) mgtL b4702 JW4200.1 mgtL 2,123 response to magnesium ion [GO:0032026]; transcriptional attenuation by ribosome [GO:0031556] response to magnesium ion [GO:0032026]; transcriptional attenuation by ribosome [GO:0031556] GO:0031556; GO:0032026 +P0ADV9 LPTC_ECOLI Lipopolysaccharide export system protein LptC lptC yrbK b3199 JW3166 yrbK lptC 21,703 Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; lipopolysaccharide transport [GO:0015920] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; transporter complex [GO:1990351] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; transporter complex [GO:1990351]; glycolipid transfer activity [GO:0017089]; identical protein binding [GO:0042802]; lipopolysaccharide transmembrane transporter activity [GO:0015221]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; lipopolysaccharide transport [GO:0015920] glycolipid transfer activity [GO:0017089]; identical protein binding [GO:0042802]; lipopolysaccharide transmembrane transporter activity [GO:0015221] GO:0005886; GO:0005887; GO:0015221; GO:0015920; GO:0016021; GO:0017089; GO:0030288; GO:0042802; GO:0043165; GO:1990351 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01915, ECO:0000269|PubMed:18424520, ECO:0000269|PubMed:20720015}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01915, ECO:0000269|PubMed:18424520, ECO:0000269|PubMed:20720015}. +P69212 MDTJ_ECOLI Spermidine export protein MdtJ mdtJ ydgF b1600 JW1592 ydgF mdtJ 13,115 choline transport [GO:0015871]; glycine betaine transport [GO:0031460]; spermidine transmembrane transport [GO:1903711]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; amino-acid betaine transmembrane transporter activity [GO:0015199]; antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; spermidine transmembrane transporter activity [GO:0015606]; transmembrane transporter activity [GO:0022857]; choline transport [GO:0015871]; glycine betaine transport [GO:0031460]; spermidine transmembrane transport [GO:1903711]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] amino-acid betaine transmembrane transporter activity [GO:0015199]; antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; spermidine transmembrane transporter activity [GO:0015606]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0015199; GO:0015220; GO:0015297; GO:0015606; GO:0015871; GO:0022857; GO:0031460; GO:0055085; GO:1903711; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P39411 NCPP_ECOLI Inosine/xanthosine triphosphatase (ITPase/XTPase) (EC 3.6.1.73) (Non-canonical purine NTP phosphatase) (Non-standard purine NTP phosphatase) (Nucleoside-triphosphate phosphatase) (NTPase) yjjX b4394 JW5801 yjjX 18,213 nucleotide metabolic process [GO:0009117]; response to antibiotic [GO:0046677]; thiamine metabolic process [GO:0006772] ITPase activity [GO:0103023]; metal ion binding [GO:0046872]; nucleoside-triphosphatase activity [GO:0017111]; nucleotide binding [GO:0000166]; nucleotide metabolic process [GO:0009117]; response to antibiotic [GO:0046677]; thiamine metabolic process [GO:0006772] ITPase activity [GO:0103023]; metal ion binding [GO:0046872]; nucleoside-triphosphatase activity [GO:0017111]; nucleotide binding [GO:0000166] GO:0000166; GO:0006772; GO:0009117; GO:0017111; GO:0046677; GO:0046872; GO:0103023 +P08337 MUTT_ECOLI 8-oxo-dGTP diphosphatase (8-oxo-dGTPase) (EC 3.6.1.55) (7,8-dihydro-8-oxoguanine-triphosphatase) (Mutator protein MutT) (dGTP pyrophosphohydrolase) mutT b0099 JW0097 mutT 14,927 DNA repair [GO:0006281]; DNA replication [GO:0006260] 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity [GO:0035539]; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [GO:0008413]; 8-oxo-dGDP phosphatase activity [GO:0044715]; 8-oxo-GDP phosphatase activity [GO:0044716]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; DNA repair [GO:0006281]; DNA replication [GO:0006260] 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity [GO:0035539]; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [GO:0008413]; 8-oxo-dGDP phosphatase activity [GO:0044715]; 8-oxo-GDP phosphatase activity [GO:0044716]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145] GO:0000287; GO:0006260; GO:0006281; GO:0008413; GO:0030145; GO:0035539; GO:0044715; GO:0044716 +P11349 NARH_ECOLI Respiratory nitrate reductase 1 beta chain (EC 1.7.5.1) (Nitrate reductase A subunit beta) (Quinol-nitrate oxidoreductase subunit beta) narH b1225 JW1216 narH 58,066 anaerobic respiration [GO:0009061]; nitrate assimilation [GO:0042128]; nitrate metabolic process [GO:0042126] intrinsic component of membrane [GO:0031224]; intrinsic component of the cytoplasmic side of the plasma membrane [GO:0031235]; membrane [GO:0016020]; NarGHI complex [GO:0044799] intrinsic component of membrane [GO:0031224]; intrinsic component of the cytoplasmic side of the plasma membrane [GO:0031235]; membrane [GO:0016020]; NarGHI complex [GO:0044799]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; nitrate reductase activity [GO:0008940]; anaerobic respiration [GO:0009061]; nitrate assimilation [GO:0042128]; nitrate metabolic process [GO:0042126] 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; nitrate reductase activity [GO:0008940] GO:0008940; GO:0009055; GO:0009061; GO:0016020; GO:0031224; GO:0031235; GO:0042126; GO:0042128; GO:0044799; GO:0046872; GO:0051538; GO:0051539 SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. +P18843 NADE_ECOLI NH(3)-dependent NAD(+) synthetase (EC 6.3.1.5) (Nicotinamide adenine dinucleotide synthetase) (NADS) (Nitrogen regulatory protein) nadE efg ntrL b1740 JW1729 efg ntrL nadE 30,637 'de novo' NAD biosynthetic process from aspartate [GO:0034628]; cellular response to DNA damage stimulus [GO:0006974]; NAD biosynthetic process [GO:0009435]; NAD salvage [GO:0034355] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; glutaminase activity [GO:0004359]; metal ion binding [GO:0046872]; NAD+ synthase (glutamine-hydrolyzing) activity [GO:0003952]; NAD+ synthase activity [GO:0008795]; 'de novo' NAD biosynthetic process from aspartate [GO:0034628]; cellular response to DNA damage stimulus [GO:0006974]; NAD biosynthetic process [GO:0009435]; NAD salvage [GO:0034355] ATP binding [GO:0005524]; glutaminase activity [GO:0004359]; metal ion binding [GO:0046872]; NAD+ synthase (glutamine-hydrolyzing) activity [GO:0003952]; NAD+ synthase activity [GO:0008795] GO:0003952; GO:0004359; GO:0005524; GO:0005737; GO:0005829; GO:0006974; GO:0008795; GO:0009435; GO:0034355; GO:0034628; GO:0046872 +P75960 NPD_ECOLI NAD-dependent protein deacylase (EC 2.3.1.286) (Regulatory protein SIR2 homolog) cobB ycfY b1120 JW1106 ycfY cobB 31,464 chemotaxis [GO:0006935]; defense response to virus [GO:0051607]; peptidyl-lysine deacetylation [GO:0034983]; peptidyl-lysine demalonylation [GO:0036047]; peptidyl-lysine desuccinylation [GO:0036049]; protein deglutarylation [GO:0061698] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+ binding [GO:0070403]; NAD-dependent protein deacetylase activity [GO:0034979]; protein-glutaryllysine deglutarylase activity [GO:0061697]; protein-malonyllysine demalonylase activity [GO:0036054]; protein-succinyllysine desuccinylase activity [GO:0036055]; zinc ion binding [GO:0008270]; chemotaxis [GO:0006935]; defense response to virus [GO:0051607]; peptidyl-lysine deacetylation [GO:0034983]; peptidyl-lysine demalonylation [GO:0036047]; peptidyl-lysine desuccinylation [GO:0036049]; protein deglutarylation [GO:0061698] NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+ binding [GO:0070403]; NAD-dependent protein deacetylase activity [GO:0034979]; protein-glutaryllysine deglutarylase activity [GO:0061697]; protein-malonyllysine demalonylase activity [GO:0036054]; protein-succinyllysine desuccinylase activity [GO:0036055]; zinc ion binding [GO:0008270] GO:0003950; GO:0005737; GO:0006935; GO:0008270; GO:0034979; GO:0034983; GO:0036047; GO:0036049; GO:0036054; GO:0036055; GO:0051607; GO:0061697; GO:0061698; GO:0070403 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01121}. +P77788 NUDG_ECOLI CTP pyrophosphohydrolase (EC 3.6.1.65) nudG ynjG b1759 JW1748 ynjG nudG 15,046 DNA repair [GO:0006281] 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity [GO:0035539]; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [GO:0008413]; 8-oxo-dGDP phosphatase activity [GO:0044715]; 8-oxo-GDP phosphatase activity [GO:0044716]; dCTP diphosphatase activity [GO:0047840]; hydrolase activity [GO:0016787]; DNA repair [GO:0006281] 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity [GO:0035539]; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [GO:0008413]; 8-oxo-dGDP phosphatase activity [GO:0044715]; 8-oxo-GDP phosphatase activity [GO:0044716]; dCTP diphosphatase activity [GO:0047840]; hydrolase activity [GO:0016787] GO:0006281; GO:0008413; GO:0016787; GO:0035539; GO:0044715; GO:0044716; GO:0047840 +P0AA16 OMPR_ECOLI DNA-binding dual transcriptional regulator OmpR (Transcriptional regulatory protein OmpR) ompR kmt ompB b3405 JW3368 kmt ompB ompR 27,354 phosphorelay signal transduction system [GO:0000160]; positive regulation of transcription, DNA-templated [GO:0045893] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; phosphorelay signal transduction system [GO:0000160]; positive regulation of transcription, DNA-templated [GO:0045893] DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000160; GO:0000976; GO:0001216; GO:0005829; GO:0032993; GO:0045893 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:3533941}. +P33136 OPGG_ECOLI Glucans biosynthesis protein G mdoG opgG b1048 JW1035 opgG mdoG 57,912 beta-glucan biosynthetic process [GO:0051274]; response to osmotic stress [GO:0006970] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; carbohydrate binding [GO:0030246]; catalytic activity [GO:0003824]; beta-glucan biosynthetic process [GO:0051274]; response to osmotic stress [GO:0006970] carbohydrate binding [GO:0030246]; catalytic activity [GO:0003824] GO:0003824; GO:0006970; GO:0030246; GO:0030288; GO:0051274 SUBCELLULAR LOCATION: Periplasm. +P0C0L2 OSMC_ECOLI Peroxiredoxin OsmC (EC 1.11.1.-) (Osmotically-inducible protein C) osmC b1482 JW1477 osmC 15,088 hyperosmotic response [GO:0006972]; response to hydroperoxide [GO:0033194]; response to oxidative stress [GO:0006979] cytosol [GO:0005829] cytosol [GO:0005829]; peroxidase activity [GO:0004601]; peroxiredoxin activity [GO:0051920]; hyperosmotic response [GO:0006972]; response to hydroperoxide [GO:0033194]; response to oxidative stress [GO:0006979] peroxidase activity [GO:0004601]; peroxiredoxin activity [GO:0051920] GO:0004601; GO:0005829; GO:0006972; GO:0006979; GO:0033194; GO:0051920 SUBCELLULAR LOCATION: Cytoplasm. +P0AFD6 NUOI_ECOLI NADH-quinone oxidoreductase subunit I (EC 7.1.1.-) (NADH dehydrogenase I subunit I) (NDH-1 subunit I) (NUO9) nuoI b2281 JW2276 nuoI 20,538 aerobic respiration [GO:0009060] NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272] NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272]; 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; NADH dehydrogenase (quinone) activity [GO:0050136]; quinone binding [GO:0048038]; aerobic respiration [GO:0009060] 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; NADH dehydrogenase (quinone) activity [GO:0050136]; quinone binding [GO:0048038] GO:0005506; GO:0005886; GO:0009060; GO:0030964; GO:0045272; GO:0048038; GO:0050136; GO:0051539 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P31677 OTSA_ECOLI Trehalose-6-phosphate synthase (TPS) (EC 2.4.1.15) (Alpha,alpha-trehalose-phosphate synthase [UDP-forming]) (Osmoregulatory trehalose synthesis protein A) (OtsA) (UDP-glucose-glucosephosphate glucosyltransferase) otsA b1896 JW5312 otsA 53,611 cellular response to DNA damage stimulus [GO:0006974]; response to osmotic stress [GO:0006970]; trehalose biosynthetic process [GO:0005992]; trehalose metabolism in response to cold stress [GO:0070415] cytosol [GO:0005829] cytosol [GO:0005829]; alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [GO:0003825]; cellular response to DNA damage stimulus [GO:0006974]; response to osmotic stress [GO:0006970]; trehalose biosynthetic process [GO:0005992]; trehalose metabolism in response to cold stress [GO:0070415] alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [GO:0003825] GO:0003825; GO:0005829; GO:0005992; GO:0006970; GO:0006974; GO:0070415 +P16687 PHNI_ECOLI Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI (RPnTP synthase subunit PhnI) (EC 2.7.8.37) (Ribose 1-methylphosphonate 5-triphosphate synthase nucleosidase subunit) phnI b4099 JW4060 phnI 38,853 organic phosphonate catabolic process [GO:0019700] alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex [GO:0061694]; carbon phosphorus lyase complex [GO:1904176] alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex [GO:0061694]; carbon phosphorus lyase complex [GO:1904176]; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity [GO:0061693]; organic phosphonate catabolic process [GO:0019700] alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity [GO:0061693] GO:0019700; GO:0061693; GO:0061694; GO:1904176 +P76114 MCBR_ECOLI HTH-type transcriptional regulator McbR mcbR yncC b1450 JW1445 yncC mcbR 25,151 negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0045892 +P08997 MASY_ECOLI Malate synthase A (MSA) (EC 2.3.3.9) aceB mas b4014 JW3974 mas aceB 60,274 glyoxylate cycle [GO:0006097]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; malate synthase activity [GO:0004474]; glyoxylate cycle [GO:0006097]; tricarboxylic acid cycle [GO:0006099] malate synthase activity [GO:0004474] GO:0004474; GO:0005737; GO:0006097; GO:0006099 SUBCELLULAR LOCATION: Cytoplasm. +P22523 MUKB_ECOLI Chromosome partition protein MukB (Structural maintenance of chromosome-related protein) mukB b0924 JW0907 mukB 170,230 cell division [GO:0051301]; chromosome condensation [GO:0030261]; chromosome segregation [GO:0007059]; DNA replication [GO:0006260]; sister chromatid cohesion [GO:0007062] condensin complex [GO:0000796]; cytosol [GO:0005829]; nucleoid [GO:0009295] condensin complex [GO:0000796]; cytosol [GO:0005829]; nucleoid [GO:0009295]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; cell division [GO:0051301]; chromosome condensation [GO:0030261]; chromosome segregation [GO:0007059]; DNA replication [GO:0006260]; sister chromatid cohesion [GO:0007062] ATP binding [GO:0005524]; DNA binding [GO:0003677]; GTP binding [GO:0005525]; identical protein binding [GO:0042802] GO:0000796; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0006260; GO:0007059; GO:0007062; GO:0009295; GO:0030261; GO:0042802; GO:0051301 SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000269|PubMed:11886550, ECO:0000269|PubMed:22380631}. Note=Restricted to the nucleoid region, far from the cell poles. +P10902 NADB_ECOLI L-aspartate oxidase (LASPO) (EC 1.4.3.16) (Quinolinate synthase B) nadB nicB b2574 JW2558 nicB nadB 60,337 'de novo' NAD biosynthetic process from aspartate [GO:0034628] cytosol [GO:0005829] cytosol [GO:0005829]; flavin adenine dinucleotide binding [GO:0050660]; L-aspartate oxidase activity [GO:0008734]; L-aspartate:fumarate oxidoreductase activity [GO:0044318]; 'de novo' NAD biosynthetic process from aspartate [GO:0034628] flavin adenine dinucleotide binding [GO:0050660]; L-aspartate:fumarate oxidoreductase activity [GO:0044318]; L-aspartate oxidase activity [GO:0008734] GO:0005829; GO:0008734; GO:0034628; GO:0044318; GO:0050660 SUBCELLULAR LOCATION: Cytoplasm. +P33590 NIKA_ECOLI Nickel-binding periplasmic protein nikA b3476 JW3441 nikA 58,719 negative chemotaxis [GO:0050919]; nickel cation transport [GO:0015675]; peptide transport [GO:0015833] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; heme binding [GO:0020037]; metal cluster binding [GO:0051540]; nickel cation binding [GO:0016151]; peptide transmembrane transporter activity [GO:1904680]; transition metal ion binding [GO:0046914]; negative chemotaxis [GO:0050919]; nickel cation transport [GO:0015675]; peptide transport [GO:0015833] heme binding [GO:0020037]; metal cluster binding [GO:0051540]; nickel cation binding [GO:0016151]; peptide transmembrane transporter activity [GO:1904680]; transition metal ion binding [GO:0046914] GO:0015675; GO:0015833; GO:0016151; GO:0020037; GO:0030288; GO:0042597; GO:0043190; GO:0046914; GO:0050919; GO:0051540; GO:1904680 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P0AFI2 PARC_ECOLI DNA topoisomerase 4 subunit A (EC 5.6.2.2) (Topoisomerase IV subunit A) parC b3019 JW2987 parC 83,831 chromosome segregation [GO:0007059]; DNA topological change [GO:0006265]; plasmid partitioning [GO:0030541]; sister chromatid cohesion [GO:0007062] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex [GO:0009330]; extrinsic component of plasma membrane [GO:0019897] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex [GO:0009330]; extrinsic component of plasma membrane [GO:0019897]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; chromosome segregation [GO:0007059]; DNA topological change [GO:0006265]; plasmid partitioning [GO:0030541]; sister chromatid cohesion [GO:0007062] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918] GO:0003677; GO:0003918; GO:0005524; GO:0005694; GO:0005737; GO:0005829; GO:0006265; GO:0007059; GO:0007062; GO:0009330; GO:0019897; GO:0030541 SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. +P77183 PAOD_ECOLI Molybdenum cofactor insertion chaperone PaoD paoD yagQ b0283 JW0277 yagQ paoD 34,954 molybdopterin cofactor binding [GO:0043546] molybdopterin cofactor binding [GO:0043546] GO:0043546 +P76077 PAAA_ECOLI 1,2-phenylacetyl-CoA epoxidase, subunit A (EC 1.14.13.149) (1,2-phenylacetyl-CoA epoxidase, catalytic subunit alpha) (1,2-phenylacetyl-CoA monooxygenase, subunit A) paaA ydbO b1388 JW1383 ydbO paaA 35,499 phenylacetate catabolic process [GO:0010124] cytosol [GO:0005829] cytosol [GO:0005829]; phenylacetyl-CoA 1,2-epoxidase activity [GO:0097266]; phenylacetate catabolic process [GO:0010124] phenylacetyl-CoA 1,2-epoxidase activity [GO:0097266] GO:0005829; GO:0010124; GO:0097266 +P76085 PAAK_ECOLI Phenylacetate-coenzyme A ligase (EC 6.2.1.30) (Phenylacetyl-CoA ligase) (PA-CoA ligase) paaK b1398 JW5218 paaK 48,953 phenylacetate catabolic process [GO:0010124] ATP binding [GO:0005524]; CoA-ligase activity [GO:0016405]; phenylacetate-CoA ligase activity [GO:0047475]; phenylacetate catabolic process [GO:0010124] ATP binding [GO:0005524]; CoA-ligase activity [GO:0016405]; phenylacetate-CoA ligase activity [GO:0047475] GO:0005524; GO:0010124; GO:0016405; GO:0047475 +P0AB10 PQIC_ECOLI Intermembrane transport lipoprotein PqiC pqiC ymbA b0952 JW5127 ymbA pqiC 20,634 anchored component of periplasmic side of cell outer membrane [GO:0036406]; outer membrane-bounded periplasmic space [GO:0030288] anchored component of periplasmic side of cell outer membrane [GO:0036406]; outer membrane-bounded periplasmic space [GO:0030288]; identical protein binding [GO:0042802] identical protein binding [GO:0042802] GO:0030288; GO:0036406; GO:0042802 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:27795327}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}; Periplasmic side {ECO:0000269|PubMed:27795327}. +P0A9M8 PTA_ECOLI Phosphate acetyltransferase (EC 2.3.1.8) (Phosphotransacetylase) pta b2297 JW2294 pta 77,172 acetate biosynthetic process [GO:0019413]; acetate catabolic process [GO:0045733]; acetate metabolic process [GO:0006083]; acetyl-CoA biosynthetic process from acetate [GO:0019427]; L-threonine catabolic process to propionate [GO:0070689] cytosol [GO:0005829] cytosol [GO:0005829]; phosphate acetyltransferase activity [GO:0008959]; zinc ion binding [GO:0008270]; acetate biosynthetic process [GO:0019413]; acetate catabolic process [GO:0045733]; acetate metabolic process [GO:0006083]; acetyl-CoA biosynthetic process from acetate [GO:0019427]; L-threonine catabolic process to propionate [GO:0070689] phosphate acetyltransferase activity [GO:0008959]; zinc ion binding [GO:0008270] GO:0005829; GO:0006083; GO:0008270; GO:0008959; GO:0019413; GO:0019427; GO:0045733; GO:0070689 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P76558 MAO2_ECOLI NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) maeB ypfF b2463 JW2447 ypfF maeB 82,417 malate metabolic process [GO:0006108] cytosol [GO:0005829] cytosol [GO:0005829]; malate dehydrogenase (decarboxylating) (NAD+) activity [GO:0004471]; malate dehydrogenase (decarboxylating) (NADP+) activity [GO:0004473]; manganese ion binding [GO:0030145]; NAD binding [GO:0051287]; oxaloacetate decarboxylase activity [GO:0008948]; transferase activity, transferring acyl groups [GO:0016746]; malate metabolic process [GO:0006108] malate dehydrogenase (decarboxylating) (NAD+) activity [GO:0004471]; malate dehydrogenase (decarboxylating) (NADP+) activity [GO:0004473]; manganese ion binding [GO:0030145]; NAD binding [GO:0051287]; oxaloacetate decarboxylase activity [GO:0008948]; transferase activity, transferring acyl groups [GO:0016746] GO:0004471; GO:0004473; GO:0005829; GO:0006108; GO:0008948; GO:0016746; GO:0030145; GO:0051287 +P77589 MHPT_ECOLI 3-(3-hydroxy-phenyl)propionate transporter (3HPP transporter) (3-(3-hydroxy-phenyl)propionate:H(+) symporter) (3HPP:H(+) symporter) mhpT yaiK b0353 JW5046 yaiK mhpT 41,551 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; symporter activity [GO:0015293] symporter activity [GO:0015293] GO:0005886; GO:0015293; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:23934492}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:23934492}. +Q46864 MQSA_ECOLI Antitoxin MqsA mqsA ygiT b3021 JW2989 ygiT mqsA 14,703 regulation of transcription, DNA-templated [GO:0006355] metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; regulation of transcription, DNA-templated [GO:0006355] metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565] GO:0006355; GO:0043565; GO:0046872 +P25745 MNMA_ECOLI tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) mnmA asuE trmU ycfB b1133 JW1119 asuE trmU ycfB mnmA 40,959 tRNA wobble position uridine thiolation [GO:0002143] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; sulfurtransferase activity [GO:0016783]; tRNA binding [GO:0000049]; tRNA wobble position uridine thiolation [GO:0002143] ATP binding [GO:0005524]; sulfurtransferase activity [GO:0016783]; tRNA binding [GO:0000049] GO:0000049; GO:0002143; GO:0005524; GO:0005829; GO:0016783 SUBCELLULAR LOCATION: Cytoplasm. +P25522 MNME_ECOLI tRNA modification GTPase MnmE (EC 3.6.-.-) mnmE thdF trmE b3706 JW3684 thdF trmE mnmE 49,231 chaperone-mediated protein folding [GO:0061077]; response to pH [GO:0009268]; tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; potassium ion binding [GO:0030955]; chaperone-mediated protein folding [GO:0061077]; response to pH [GO:0009268]; tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] GDP binding [GO:0019003]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; potassium ion binding [GO:0030955] GO:0002098; GO:0003924; GO:0005525; GO:0005737; GO:0005829; GO:0005886; GO:0009268; GO:0019003; GO:0030488; GO:0030955; GO:0042802; GO:0061077 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00379, ECO:0000269|PubMed:10601028}. Note=Partially associated with the inner membrane. +P0AFF4 NUPG_ECOLI Nucleoside permease NupG (Nucleoside-transport system protein NupG) nupG b2964 JW2932 nupG 46,389 adenosine transport [GO:0032238]; organic substance transport [GO:0071702]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]; uridine transport [GO:0015862] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cytidine transmembrane transporter activity [GO:0015212]; nucleoside:proton symporter activity [GO:0015506]; pyrimidine nucleoside transmembrane transporter activity [GO:0015214]; uridine transmembrane transporter activity [GO:0015213]; adenosine transport [GO:0032238]; organic substance transport [GO:0071702]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]; uridine transport [GO:0015862] cytidine transmembrane transporter activity [GO:0015212]; nucleoside:proton symporter activity [GO:0015506]; pyrimidine nucleoside transmembrane transporter activity [GO:0015214]; uridine transmembrane transporter activity [GO:0015213] GO:0005886; GO:0005887; GO:0015212; GO:0015213; GO:0015214; GO:0015506; GO:0015860; GO:0015862; GO:0015864; GO:0032238; GO:0071702 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02049, ECO:0000269|PubMed:15513740, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:3311747}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02049}. +P27896 NARQ_ECOLI Nitrate/nitrite sensor protein NarQ (EC 2.7.13.3) narQ b2469 JW2453 narQ 63,697 cellular response to nitrate [GO:0071249]; cellular response to nitrite [GO:0071250]; nitrate assimilation [GO:0042128]; signal transduction [GO:0007165] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; protein dimerization activity [GO:0046983]; cellular response to nitrate [GO:0071249]; cellular response to nitrite [GO:0071250]; nitrate assimilation [GO:0042128]; signal transduction [GO:0007165] ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; protein dimerization activity [GO:0046983] GO:0000155; GO:0005524; GO:0005886; GO:0007165; GO:0016021; GO:0042128; GO:0046983; GO:0071249; GO:0071250 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0AFA9 NIKC_ECOLI Nickel transport system permease protein NikC nikC b3478 JW3443 nikC 30,362 nickel cation transmembrane transport [GO:0035444] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; dipeptide transmembrane transporter activity [GO:0071916]; nickel cation binding [GO:0016151]; nickel cation transmembrane transporter activity [GO:0015099]; nickel cation transmembrane transport [GO:0035444] dipeptide transmembrane transporter activity [GO:0071916]; nickel cation binding [GO:0016151]; nickel cation transmembrane transporter activity [GO:0015099] GO:0005886; GO:0005887; GO:0015099; GO:0016151; GO:0035444; GO:0071916 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0ADZ4 RS15_ECOLI 30S ribosomal protein S15 (Small ribosomal subunit protein uS15) rpsO secC b3165 JW3134 secC rpsO 10,269 regulation of translation [GO:0006417]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; mRNA binding involved in posttranscriptional gene silencing [GO:1903231]; rRNA binding [GO:0019843]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]; regulation of translation [GO:0006417]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] mRNA binding involved in posttranscriptional gene silencing [GO:1903231]; rRNA binding [GO:0019843]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735] GO:0000028; GO:0003735; GO:0005829; GO:0006412; GO:0006417; GO:0019843; GO:0022627; GO:0070181; GO:1903231 +P0AFX7 RSEA_ECOLI Anti-sigma-E factor RseA (Regulator of SigE) (Sigma-E anti-sigma factor RseA) (Sigma-E factor negative regulatory protein) rseA mclA yfiJ b2572 JW2556 mclA yfiJ rseA 24,321 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; sigma factor antagonist activity [GO:0016989] sigma factor antagonist activity [GO:0016989] GO:0005886; GO:0016021; GO:0016989 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:11777003, ECO:0000269|PubMed:12183369, ECO:0000269|PubMed:9159522, ECO:0000269|PubMed:9159523}; Single-pass type II membrane protein {ECO:0000269|PubMed:11777003, ECO:0000269|PubMed:12183369, ECO:0000269|PubMed:9159522, ECO:0000269|PubMed:9159523}. Note=Following cleavage by DegS the large fragment of the protein is still in the inner membrane and retains its anti-sigma-E activity. +P0AEH1 RSEP_ECOLI Regulator of sigma-E protease RseP (EC 3.4.24.-) (S2P endopeptidase) (Site-2 protease RseP) (S2P protease RseP) (Site-2-type intramembrane protease) rseP ecfE yaeL b0176 JW0171 ecfE yaeL rseP 49,071 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; anti-sigma factor antagonist activity [GO:0043856]; antisigma factor binding [GO:0045152]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] anti-sigma factor antagonist activity [GO:0043856]; antisigma factor binding [GO:0045152]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222] GO:0004222; GO:0005886; GO:0005887; GO:0043856; GO:0045152; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:11689431, ECO:0000269|PubMed:11750129, ECO:0000269|PubMed:11867724, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:11689431, ECO:0000269|PubMed:11750129, ECO:0000269|PubMed:11867724, ECO:0000269|PubMed:15919996}. +P02358 RS6_ECOLI 30S ribosomal protein S6 (Small ribosomal subunit protein bS6) [Cleaved into: 30S ribosomal protein S6, fully modified isoform; 30S ribosomal protein S6, non-modified isoform] rpsF b4200 JW4158 rpsF 15,703 translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; mRNA 5'-UTR binding [GO:0048027]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412] mRNA 5'-UTR binding [GO:0048027]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735] GO:0003735; GO:0005829; GO:0006412; GO:0022627; GO:0048027; GO:0070181 +P25665 METE_ECOLI 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) (Cobalamin-independent methionine synthase) (Methionine synthase, vitamin-B12 independent isozyme) metE b3829 JW3805 metE 84,674 homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; methylation [GO:0032259]; tetrahydrofolate interconversion [GO:0035999] cytosol [GO:0005829] cytosol [GO:0005829]; 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity [GO:0003871]; methionine synthase activity [GO:0008705]; zinc ion binding [GO:0008270]; homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; methylation [GO:0032259]; tetrahydrofolate interconversion [GO:0035999] 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity [GO:0003871]; methionine synthase activity [GO:0008705]; zinc ion binding [GO:0008270] GO:0003871; GO:0005829; GO:0008270; GO:0008705; GO:0009086; GO:0032259; GO:0035999; GO:0050667 +P16384 MIAA_ECOLI tRNA dimethylallyltransferase (EC 2.5.1.75) (Dimethylallyl diphosphate:tRNA dimethylallyltransferase) (DMAPP:tRNA dimethylallyltransferase) (DMATase) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (IPTase) miaA trpX b4171 JW4129 trpX miaA 35,065 cellular response to heat [GO:0034605]; regulation of cytoplasmic translation in response to stress [GO:1990497]; tRNA modification [GO:0006400] ATP binding [GO:0005524]; tRNA dimethylallyltransferase activity [GO:0052381]; cellular response to heat [GO:0034605]; regulation of cytoplasmic translation in response to stress [GO:1990497]; tRNA modification [GO:0006400] ATP binding [GO:0005524]; tRNA dimethylallyltransferase activity [GO:0052381] GO:0005524; GO:0006400; GO:0034605; GO:0052381; GO:1990497 +P60752 MSBA_ECOLI ATP-dependent lipid A-core flippase (EC 7.5.2.6) (Lipid A export ATP-binding/permease protein MsbA) (Lipid flippase) msbA b0914 JW0897 msbA 64,461 lipid translocation [GO:0034204]; lipopolysaccharide transport [GO:0015920]; transmembrane transport [GO:0055085] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; ATPase-coupled transmembrane transporter activity [GO:0042626]; drug binding [GO:0008144]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; lipopolysaccharide floppase activity [GO:0015437]; lipid translocation [GO:0034204]; lipopolysaccharide transport [GO:0015920]; transmembrane transport [GO:0055085] ABC-type xenobiotic transporter activity [GO:0008559]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; drug binding [GO:0008144]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; lipopolysaccharide floppase activity [GO:0015437] GO:0005524; GO:0005886; GO:0005887; GO:0008144; GO:0008289; GO:0008559; GO:0015437; GO:0015920; GO:0016020; GO:0034040; GO:0034204; GO:0042626; GO:0042802; GO:0043190; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01703, ECO:0000269|PubMed:12119303, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:8809774}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01703, ECO:0000269|PubMed:8809774}. +P33591 NIKB_ECOLI Nickel transport system permease protein NikB nikB b3477 JW3442 nikB 35,248 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; dipeptide transmembrane transporter activity [GO:0071916]; nickel cation binding [GO:0016151]; nickel cation transmembrane transporter activity [GO:0015099] dipeptide transmembrane transporter activity [GO:0071916]; nickel cation binding [GO:0016151]; nickel cation transmembrane transporter activity [GO:0015099] GO:0005886; GO:0005887; GO:0015099; GO:0016151; GO:0071916 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P31806 NNR_ECOLI Bifunctional NAD(P)H-hydrate repair enzyme Nnr (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)] nnr yjeF b4167 JW4125 yjeF nnr 54,650 metabolite repair [GO:0110051]; nicotinamide nucleotide metabolic process [GO:0046496] ADP-dependent NAD(P)H-hydrate dehydratase activity [GO:0052855]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; NADHX epimerase activity [GO:0052856]; NADPHX epimerase activity [GO:0052857]; metabolite repair [GO:0110051]; nicotinamide nucleotide metabolic process [GO:0046496] ADP-dependent NAD(P)H-hydrate dehydratase activity [GO:0052855]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; NADHX epimerase activity [GO:0052856]; NADPHX epimerase activity [GO:0052857] GO:0005524; GO:0046496; GO:0046872; GO:0052855; GO:0052856; GO:0052857; GO:0110051 +P0ACL9 PDHR_ECOLI Pyruvate dehydrogenase complex repressor pdhR aceC genA yacB b0113 JW0109 aceC genA yacB pdhR 29,425 negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0045892; GO:0045893 +P37613 PANZ_ECOLI PanD regulatory factor panZ panM yhhK b3459 JW3424 panM yhhK panZ 14,506 negative regulation of catalytic activity [GO:0043086]; pantothenate biosynthetic process [GO:0015940]; protein processing [GO:0016485]; zymogen activation [GO:0031638] acetyl-CoA binding [GO:1905502]; N-acetyltransferase activity [GO:0008080]; negative regulation of catalytic activity [GO:0043086]; pantothenate biosynthetic process [GO:0015940]; protein processing [GO:0016485]; zymogen activation [GO:0031638] acetyl-CoA binding [GO:1905502]; N-acetyltransferase activity [GO:0008080] GO:0008080; GO:0015940; GO:0016485; GO:0031638; GO:0043086; GO:1905502 +P0A9J4 PANE_ECOLI 2-dehydropantoate 2-reductase (EC 1.1.1.169) (Ketopantoate reductase) (KPA reductase) (KPR) panE apbA b0425 JW0415 apbA panE 33,871 pantothenate biosynthetic process [GO:0015940] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 2-dehydropantoate 2-reductase activity [GO:0008677]; NADP binding [GO:0050661]; pantothenate biosynthetic process [GO:0015940] 2-dehydropantoate 2-reductase activity [GO:0008677]; NADP binding [GO:0050661] GO:0005737; GO:0008677; GO:0015940; GO:0050661 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AC86 PHSG_ECOLI Glycogen phosphorylase (EC 2.4.1.1) glgP glgY b3428 JW3391 glgY glgP 93,173 glycogen catabolic process [GO:0005980] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; glycogen phosphorylase activity [GO:0008184]; linear malto-oligosaccharide phosphorylase activity [GO:0102250]; pyridoxal phosphate binding [GO:0030170]; SHG alpha-glucan phosphorylase activity [GO:0102499]; glycogen catabolic process [GO:0005980] glycogen phosphorylase activity [GO:0008184]; linear malto-oligosaccharide phosphorylase activity [GO:0102250]; pyridoxal phosphate binding [GO:0030170]; SHG alpha-glucan phosphorylase activity [GO:0102499] GO:0005737; GO:0005980; GO:0008184; GO:0030170; GO:0102250; GO:0102499 +Q57083 PERR_ECOLI HTH-type transcriptional regulator PerR (Peroxide resistance protein PerR) perR b0254 JW0244 perR 33,639 transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0006351; GO:0042802; GO:0043565 +P37590 PMRD_ECOLI Signal transduction protein PmrD (BasR post-transcriptional activator) (Polymyxin resistance protein PmrD) pmrD b2259 JW2254 pmrD 9,871 response to antibiotic [GO:0046677] response to antibiotic [GO:0046677] GO:0046677 +P07013 PRIB_ECOLI Primosomal replication protein N priB b4201 JW4159 priB 11,442 DNA replication, synthesis of RNA primer [GO:0006269]; DNA replication initiation [GO:0006270]; plasmid maintenance [GO:0006276]; response to radiation [GO:0009314] pre-primosome complex [GO:1990099] pre-primosome complex [GO:1990099]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of RNA primer [GO:0006269]; plasmid maintenance [GO:0006276]; response to radiation [GO:0009314] identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697] GO:0003697; GO:0006269; GO:0006270; GO:0006276; GO:0009314; GO:0042802; GO:1990099 +P25889 PREA_ECOLI NAD-dependent dihydropyrimidine dehydrogenase subunit PreA (DPD) (EC 1.3.1.1) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) preA yeiA b2147 JW2134 yeiA preA 45,069 pyrimidine nucleobase catabolic process [GO:0006208]; thymine catabolic process [GO:0006210]; uracil catabolic process [GO:0006212] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 4 iron, 4 sulfur cluster binding [GO:0051539]; dihydropyrimidine dehydrogenase (NADP+) activity [GO:0017113]; dihydrouracil dehydrogenase (NAD+) activity [GO:0004159]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; NADH dehydrogenase activity [GO:0003954]; NADP binding [GO:0050661]; uracil binding [GO:0002058]; pyrimidine nucleobase catabolic process [GO:0006208]; thymine catabolic process [GO:0006210]; uracil catabolic process [GO:0006212] 4 iron, 4 sulfur cluster binding [GO:0051539]; dihydropyrimidine dehydrogenase (NADP+) activity [GO:0017113]; dihydrouracil dehydrogenase (NAD+) activity [GO:0004159]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; NADH dehydrogenase activity [GO:0003954]; NADP binding [GO:0050661]; uracil binding [GO:0002058] GO:0002058; GO:0003954; GO:0004159; GO:0005737; GO:0006208; GO:0006210; GO:0006212; GO:0017113; GO:0046872; GO:0050661; GO:0051536; GO:0051539 +P31452 PTXC_ECOLI Phosphotransferase IIC component GlvC (PTS system EIIC component) glvC ptiC b3683 JW3660 ptiC glvC 39,692 carbohydrate transport [GO:0008643]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; carbohydrate transport [GO:0008643]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005886; GO:0005887; GO:0008643; GO:0008982; GO:0009401; GO:0090563 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein. Note=When overexpressed using vectors that provide a promoter and ribosome binding site (PubMed:15919996). {ECO:0000269|PubMed:15919996}. +P0C037 PPNP_ECOLI Pyrimidine/purine nucleoside phosphorylase (EC 2.4.2.1) (EC 2.4.2.2) (Adenosine phosphorylase) (Cytidine phosphorylase) (Guanosine phosphorylase) (EC 2.4.2.15) (Inosine phosphorylase) (Thymidine phosphorylase) (EC 2.4.2.4) (Uridine phosphorylase) (EC 2.4.2.3) (Xanthosine phosphorylase) ppnP yaiE b0391 JW0382 yaiE ppnP 10,234 cytosol [GO:0005829] cytosol [GO:0005829]; guanosine phosphorylase activity [GO:0047975]; purine-nucleoside phosphorylase activity [GO:0004731]; pyrimidine-nucleoside phosphorylase activity [GO:0016154]; thymidine phosphorylase activity [GO:0009032]; uridine phosphorylase activity [GO:0004850] guanosine phosphorylase activity [GO:0047975]; purine-nucleoside phosphorylase activity [GO:0004731]; pyrimidine-nucleoside phosphorylase activity [GO:0016154]; thymidine phosphorylase activity [GO:0009032]; uridine phosphorylase activity [GO:0004850] GO:0004731; GO:0004850; GO:0005829; GO:0009032; GO:0016154; GO:0047975 +P77212 RCLA_ECOLI Probable pyridine nucleotide-disulfide oxidoreductase RclA (Reactive chlorine resistance protein A) rclA ykgC b0304 JW5040 ykgC rclA 48,244 cell redox homeostasis [GO:0045454]; response to hypochlorite [GO:1901530] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [GO:0016668]; cell redox homeostasis [GO:0045454]; response to hypochlorite [GO:1901530] flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [GO:0016668] GO:0005737; GO:0016668; GO:0045454; GO:0050660; GO:1901530 +P0DMC7 RCSB_ECOLI Transcriptional regulatory protein RcsB (Capsular synthesis regulator component B) rcsB b2217 JW2205 rcsB 23,671 negative regulation of transcription, DNA-templated [GO:0045892]; phosphorelay signal transduction system [GO:0000160]; positive regulation of cell projection organization [GO:0031346]; positive regulation of transcription, DNA-templated [GO:0045893]; response to antibiotic [GO:0046677]; single-species biofilm formation on inanimate substrate [GO:0044011]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; negative regulation of transcription, DNA-templated [GO:0045892]; phosphorelay signal transduction system [GO:0000160]; positive regulation of cell projection organization [GO:0031346]; positive regulation of transcription, DNA-templated [GO:0045893]; response to antibiotic [GO:0046677]; single-species biofilm formation on inanimate substrate [GO:0044011]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802] GO:0000160; GO:0001216; GO:0001217; GO:0003677; GO:0005829; GO:0006351; GO:0031346; GO:0042802; GO:0044011; GO:0045892; GO:0045893; GO:0046677 +P0DMC5 RCSC_ECOLI Sensor histidine kinase RcsC (EC 2.7.13.3) (Capsular synthesis regulator component C) rcsC b2218 JW5917/JW5920 rcsC 106,506 cellular response to osmotic stress [GO:0071470]; phosphorelay signal transduction system [GO:0000160]; protein autophosphorylation [GO:0046777]; regulation of transcription, DNA-templated [GO:0006355]; single-species biofilm formation [GO:0044010] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; cellular response to osmotic stress [GO:0071470]; phosphorelay signal transduction system [GO:0000160]; protein autophosphorylation [GO:0046777]; regulation of transcription, DNA-templated [GO:0006355]; single-species biofilm formation [GO:0044010] ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155] GO:0000155; GO:0000160; GO:0005524; GO:0005886; GO:0005887; GO:0006355; GO:0044010; GO:0046777; GO:0071470 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00979, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2404948}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00979, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2404948}. +P33230 RCBA_ECOLI Double-strand break reduction protein rcbA ydaC b1347 JW1341 ydaC rcbA 7,863 DNA metabolic process [GO:0006259]; response to antibiotic [GO:0046677] DNA metabolic process [GO:0006259]; response to antibiotic [GO:0046677] GO:0006259; GO:0046677 +P15032 RECE_ECOLI Exodeoxyribonuclease 8 (EC 3.1.11.-) (Exodeoxyribonuclease VIII) (EXO VIII) recE b1350 JW1344 recE 96,368 double-stranded DNA 5'-3' exodeoxyribonuclease activity [GO:0051908]; identical protein binding [GO:0042802] double-stranded DNA 5'-3' exodeoxyribonuclease activity [GO:0051908]; identical protein binding [GO:0042802] GO:0042802; GO:0051908 +P0AGL5 RATA_ECOLI Ribosome association toxin RatA (Toxin RatA) ratA pasT yfjG b2619 JW2600 pasT yfjG ratA 17,727 negative regulation of translational initiation [GO:0045947] ribosomal large subunit binding [GO:0043023]; negative regulation of translational initiation [GO:0045947] ribosomal large subunit binding [GO:0043023] GO:0043023; GO:0045947 +P77215 RHMD_ECOLI L-rhamnonate dehydratase (RhamD) (EC 4.2.1.90) rhmD yfaW b2247 JW2241 yfaW rhmD 44,226 carbohydrate catabolic process [GO:0016052]; cellular amino acid catabolic process [GO:0009063] hydro-lyase activity [GO:0016836]; identical protein binding [GO:0042802]; L-rhamnonate dehydratase activity [GO:0050032]; magnesium ion binding [GO:0000287]; carbohydrate catabolic process [GO:0016052]; cellular amino acid catabolic process [GO:0009063] hydro-lyase activity [GO:0016836]; identical protein binding [GO:0042802]; L-rhamnonate dehydratase activity [GO:0050032]; magnesium ion binding [GO:0000287] GO:0000287; GO:0009063; GO:0016052; GO:0016836; GO:0042802; GO:0050032 +P0A7L3 RL20_ECOLI 50S ribosomal protein L20 (Large ribosomal subunit protein bL20) rplT pdzA b1716 JW1706 pdzA rplT 13,497 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit rRNA binding [GO:0070180]; mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735]; translation repressor activity, mRNA regulatory element binding [GO:0000900]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] large ribosomal subunit rRNA binding [GO:0070180]; mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735]; translation repressor activity, mRNA regulatory element binding [GO:0000900] GO:0000027; GO:0000900; GO:0003729; GO:0003735; GO:0005829; GO:0006412; GO:0022625; GO:0070180 +P0A8I8 RLMH_ECOLI Ribosomal RNA large subunit methyltransferase H (EC 2.1.1.177) (23S rRNA (pseudouridine1915-N3)-methyltransferase) (23S rRNA m3Psi1915 methyltransferase) (rRNA (pseudouridine-N3-)-methyltransferase RlmH) rlmH ybeA b0636 JW0631 ybeA rlmH 17,341 rRNA base methylation [GO:0070475]; rRNA methylation [GO:0031167] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; protein homodimerization activity [GO:0042803]; ribosome binding [GO:0043022]; rRNA (pseudouridine-N3-)-methyltransferase activity [GO:0070038]; rRNA base methylation [GO:0070475]; rRNA methylation [GO:0031167] protein homodimerization activity [GO:0042803]; ribosome binding [GO:0043022]; rRNA (pseudouridine-N3-)-methyltransferase activity [GO:0070038] GO:0005737; GO:0031167; GO:0042803; GO:0043022; GO:0070038; GO:0070475 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00658, ECO:0000305}. +P0C0R7 RLME_ECOLI Ribosomal RNA large subunit methyltransferase E (EC 2.1.1.166) (23S rRNA Um2552 methyltransferase) (Cell division protein FtsJ) (rRNA (uridine-2'-O-)-methyltransferase) rlmE ftsJ mrsF rrmJ b3179 JW3146 ftsJ mrsF rrmJ rlmE 23,335 enzyme-directed rRNA 2'-O-methylation [GO:0000453]; ribosomal large subunit assembly [GO:0000027]; RNA methylation [GO:0001510] cytosol [GO:0005829] cytosol [GO:0005829]; RNA methyltransferase activity [GO:0008173]; rRNA (uridine-2'-O-)-methyltransferase activity [GO:0008650]; enzyme-directed rRNA 2'-O-methylation [GO:0000453]; ribosomal large subunit assembly [GO:0000027]; RNA methylation [GO:0001510] RNA methyltransferase activity [GO:0008173]; rRNA (uridine-2'-O-)-methyltransferase activity [GO:0008650] GO:0000027; GO:0000453; GO:0001510; GO:0005829; GO:0008173; GO:0008650 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P37759 RMLB1_ECOLI dTDP-glucose 4,6-dehydratase 1 (EC 4.2.1.46) rfbB rmlB b2041 JW2026 rmlB rfbB 40,558 dTDP-rhamnose biosynthetic process [GO:0019305]; extracellular polysaccharide biosynthetic process [GO:0045226]; lipopolysaccharide biosynthetic process [GO:0009103]; nucleotide-sugar biosynthetic process [GO:0009226]; O antigen biosynthetic process [GO:0009243] cytosol [GO:0005829] cytosol [GO:0005829]; dTDP-glucose 4,6-dehydratase activity [GO:0008460]; identical protein binding [GO:0042802]; dTDP-rhamnose biosynthetic process [GO:0019305]; extracellular polysaccharide biosynthetic process [GO:0045226]; lipopolysaccharide biosynthetic process [GO:0009103]; nucleotide-sugar biosynthetic process [GO:0009226]; O antigen biosynthetic process [GO:0009243] dTDP-glucose 4,6-dehydratase activity [GO:0008460]; identical protein binding [GO:0042802] GO:0005829; GO:0008460; GO:0009103; GO:0009226; GO:0009243; GO:0019305; GO:0042802; GO:0045226 +P0ACS7 RPIR_ECOLI HTH-type transcriptional regulator RpiR (Als operon repressor) rpiR alsR yjcY b4089 JW4050 alsR yjcY rpiR 32,362 carbohydrate derivative metabolic process [GO:1901135]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] carbohydrate derivative binding [GO:0097367]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; carbohydrate derivative metabolic process [GO:1901135]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] carbohydrate derivative binding [GO:0097367]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006355; GO:0045892; GO:0097367; GO:1901135 +P0AF24 NAGD_ECOLI Ribonucleotide monophosphatase NagD (EC 3.1.3.5) nagD b0675 JW0661 nagD 27,163 carbohydrate metabolic process [GO:0005975]; UMP catabolic process [GO:0046050] cytosol [GO:0005829] cytosol [GO:0005829]; 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; carbohydrate metabolic process [GO:0005975]; UMP catabolic process [GO:0046050] 5'-nucleotidase activity [GO:0008253]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791] GO:0000287; GO:0005829; GO:0005975; GO:0008253; GO:0016791; GO:0046050 +P0A759 NAGB_ECOLI Glucosamine-6-phosphate deaminase (EC 3.5.99.6) (GlcN6P deaminase) (GNPDA) (Glucosamine-6-phosphate isomerase) nagB glmD b0678 JW0664 glmD nagB 29,774 carbohydrate metabolic process [GO:0005975]; glucosamine catabolic process [GO:0006043]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glucosamine-6-phosphate deaminase activity [GO:0004342]; identical protein binding [GO:0042802]; carbohydrate metabolic process [GO:0005975]; glucosamine catabolic process [GO:0006043]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] glucosamine-6-phosphate deaminase activity [GO:0004342]; identical protein binding [GO:0042802] GO:0004342; GO:0005737; GO:0005829; GO:0005975; GO:0006043; GO:0006046; GO:0006048; GO:0019262; GO:0042802 +P0AF28 NARL_ECOLI Nitrate/nitrite response regulator protein NarL narL frdR b1221 JW1212 frdR narL 23,927 nitrate assimilation [GO:0042128]; phosphorelay signal transduction system [GO:0000160]; regulation of gene expression [GO:0010468]; regulation of nitrate assimilation [GO:0090352]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; nitrate assimilation [GO:0042128]; phosphorelay signal transduction system [GO:0000160]; regulation of gene expression [GO:0010468]; regulation of nitrate assimilation [GO:0090352]; regulation of transcription, DNA-templated [GO:0006355] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000160; GO:0000976; GO:0001217; GO:0003677; GO:0005524; GO:0005829; GO:0006355; GO:0010468; GO:0032993; GO:0042128; GO:0042802; GO:0090352 +P0AF26 NARJ_ECOLI Nitrate reductase molybdenum cofactor assembly chaperone NarJ (Redox enzyme maturation protein NarJ) narJ b1226 JW1217 narJ 26,449 chaperone-mediated protein complex assembly [GO:0051131]; nitrate assimilation [GO:0042128] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; metallochaperone activity [GO:0016530]; unfolded protein binding [GO:0051082]; chaperone-mediated protein complex assembly [GO:0051131]; nitrate assimilation [GO:0042128] metallochaperone activity [GO:0016530]; unfolded protein binding [GO:0051082] GO:0005737; GO:0016530; GO:0042128; GO:0051082; GO:0051131 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9305880}. +P33937 NAPA_ECOLI Periplasmic nitrate reductase (EC 1.9.6.1) napA yojC yojD yojE b2206 JW2194 yojC yojD yojE napA 93,042 anaerobic respiration [GO:0009061]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; nitrate assimilation [GO:0042128] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; nitrate reductase (cytochrome) activity [GO:0050140]; nitrate reductase activity [GO:0008940]; anaerobic respiration [GO:0009061]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; nitrate assimilation [GO:0042128] 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; iron ion binding [GO:0005506]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; nitrate reductase (cytochrome) activity [GO:0050140]; nitrate reductase activity [GO:0008940] GO:0005506; GO:0006777; GO:0008940; GO:0009055; GO:0009061; GO:0030151; GO:0030288; GO:0042128; GO:0042597; GO:0043546; GO:0050140; GO:0051539 SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_01630, ECO:0000269|PubMed:10234835}. +P76241 NIMR_ECOLI HTH-type transcriptional regulator NimR (Regulator of nimT) nimR yeaM b1790 JW1779 yeaM nimR 30,554 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003677; GO:0003700; GO:0006355; GO:0043565; GO:0045892 +P33599 NUOCD_ECOLI NADH-quinone oxidoreductase subunit C/D (EC 7.1.1.-) (NADH dehydrogenase I subunit C/D) (NDH-1 subunit C/D) (NUO3/NUO4) nuoC nuoCD nuoD b2286 JW5375 nuoCD nuoD nuoC 68,236 cytoplasm [GO:0005737]; membrane [GO:0016020]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272] cytoplasm [GO:0005737]; membrane [GO:0016020]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] GO:0005737; GO:0005886; GO:0008137; GO:0016020; GO:0030964; GO:0045272; GO:0048038; GO:0051287 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16079137}. Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01359, ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01359, ECO:0000269|PubMed:16079137}. +P0ADA7 OSMB_ECOLI Osmotically-inducible lipoprotein B osmB b1283 JW1275 osmB 6,948 outer membrane [GO:0019867]; plasma membrane [GO:0005886] outer membrane [GO:0019867]; plasma membrane [GO:0005886] GO:0005886; GO:0019867 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P0AG82 PSTS_ECOLI Phosphate-binding protein PstS (PBP) pstS phoS b3728 JW3706 phoS pstS 37,024 cellular response to DNA damage stimulus [GO:0006974]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; regulation of phosphatase activity [GO:0010921]; response to radiation [GO:0009314] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288]; phosphate ion binding [GO:0042301]; cellular response to DNA damage stimulus [GO:0006974]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; regulation of phosphatase activity [GO:0010921]; response to radiation [GO:0009314] phosphate ion binding [GO:0042301] GO:0006817; GO:0006974; GO:0009314; GO:0010921; GO:0030288; GO:0035435; GO:0042301; GO:0043190 SUBCELLULAR LOCATION: Periplasm. +P09546 PUTA_ECOLI Bifunctional protein PutA [Includes: Proline dehydrogenase (EC 1.5.5.2) (Proline oxidase); Delta-1-pyrroline-5-carboxylate dehydrogenase (P5C dehydrogenase) (EC 1.2.1.88) (L-glutamate gamma-semialdehyde dehydrogenase)] putA poaA b1014 JW0999 poaA putA 143,815 negative regulation of transcription, DNA-templated [GO:0045892]; proline biosynthetic process [GO:0006561]; proline catabolic process to glutamate [GO:0010133]; response to oxidative stress [GO:0006979] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; 1-pyrroline-5-carboxylate dehydrogenase activity [GO:0003842]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity [GO:0001217]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; proline dehydrogenase activity [GO:0004657]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription, DNA-templated [GO:0045892]; proline biosynthetic process [GO:0006561]; proline catabolic process to glutamate [GO:0010133]; response to oxidative stress [GO:0006979] 1-pyrroline-5-carboxylate dehydrogenase activity [GO:0003842]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity [GO:0001217]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620]; proline dehydrogenase activity [GO:0004657]; sequence-specific DNA binding [GO:0043565] GO:0000986; GO:0001217; GO:0003677; GO:0003842; GO:0004657; GO:0005829; GO:0005886; GO:0006561; GO:0006979; GO:0009898; GO:0010133; GO:0016620; GO:0042802; GO:0043565; GO:0045892; GO:0050660 +P07117 PUTP_ECOLI Sodium/proline symporter (Proline permease) (Propionate transporter) putP b1015 JW1001 putP 54,344 proline transmembrane transport [GO:0035524]; proline transport [GO:0015824]; short-chain fatty acid transport [GO:0015912] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; proline:sodium symporter activity [GO:0005298]; sodium ion binding [GO:0031402]; proline transmembrane transport [GO:0035524]; proline transport [GO:0015824]; short-chain fatty acid transport [GO:0015912] proline:sodium symporter activity [GO:0005298]; sodium ion binding [GO:0031402] GO:0005298; GO:0005886; GO:0005887; GO:0015824; GO:0015912; GO:0031402; GO:0035524 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137}. +P09029 PURK_ECOLI N5-carboxyaminoimidazole ribonucleotide synthase (N5-CAIR synthase) (EC 6.3.4.18) (5-(carboxyamino)imidazole ribonucleotide synthetase) purK b0522 JW0511 purK 39,461 'de novo' IMP biosynthetic process [GO:0006189] cytosol [GO:0005829] cytosol [GO:0005829]; 5-(carboxyamino)imidazole ribonucleotide synthase activity [GO:0034028]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylaminoimidazole carboxylase activity [GO:0004638]; 'de novo' IMP biosynthetic process [GO:0006189] 5-(carboxyamino)imidazole ribonucleotide synthase activity [GO:0034028]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylaminoimidazole carboxylase activity [GO:0004638] GO:0004638; GO:0005524; GO:0005829; GO:0006189; GO:0034028; GO:0046872 +P40719 QSEC_ECOLI Sensor protein QseC (EC 2.7.13.3) qseC ygiY b3026 JW2994 ygiY qseC 50,282 phosphorelay signal transduction system [GO:0000160] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; phosphorelay signal transduction system [GO:0000160] ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155] GO:0000155; GO:0000160; GO:0005524; GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76062 RACR_ECOLI Prophage repressor RacR (Rac prophage repressor) racR ydaR b1356 JW1351 ydaR racR 17,663 negative regulation of DNA-templated transcription, initiation [GO:2000143] DNA binding [GO:0003677]; DNA-binding transcription repressor activity [GO:0001217]; negative regulation of DNA-templated transcription, initiation [GO:2000143] DNA binding [GO:0003677]; DNA-binding transcription repressor activity [GO:0001217] GO:0001217; GO:0003677; GO:2000143 +P76469 RHMA_ECOLI 2-keto-3-deoxy-L-rhamnonate aldolase (KDR aldolase) (EC 4.1.2.53) (2-dehydro-3-deoxyrhamnonate aldolase) (2-keto-3-deoxy acid sugar aldolase) rhmA yfaU b2245 JW2239 yfaU rhmA 28,916 cellular aromatic compound metabolic process [GO:0006725]; protein hexamerization [GO:0034214] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 2-keto-3-deoxy-L-rhamnonate aldolase activity [GO:0106099]; aldehyde-lyase activity [GO:0016832]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nickel cation binding [GO:0016151]; cellular aromatic compound metabolic process [GO:0006725]; protein hexamerization [GO:0034214] 2-keto-3-deoxy-L-rhamnonate aldolase activity [GO:0106099]; aldehyde-lyase activity [GO:0016832]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nickel cation binding [GO:0016151] GO:0000287; GO:0005737; GO:0006725; GO:0016151; GO:0016832; GO:0034214; GO:0042802; GO:0106099 +P27129 RFAJ_ECOLI Lipopolysaccharide 1,2-glucosyltransferase (EC 2.4.1.58) rfaJ waaJ b3626 JW3601 waaJ rfaJ 39,040 lipopolysaccharide core region biosynthetic process [GO:0009244] lipopolysaccharide 3-alpha-galactosyltransferase activity [GO:0008918]; lipopolysaccharide glucosyltransferase I activity [GO:0008919]; metal ion binding [GO:0046872]; lipopolysaccharide core region biosynthetic process [GO:0009244] lipopolysaccharide 3-alpha-galactosyltransferase activity [GO:0008918]; lipopolysaccharide glucosyltransferase I activity [GO:0008919]; metal ion binding [GO:0046872] GO:0008918; GO:0008919; GO:0009244; GO:0046872 +P0AFU8 RISA_ECOLI Riboflavin synthase (RS) (EC 2.5.1.9) ribC ribE b1662 JW1654 ribE ribC 23,445 riboflavin biosynthetic process [GO:0009231] cytosol [GO:0005829] cytosol [GO:0005829]; riboflavin synthase activity [GO:0004746]; riboflavin biosynthetic process [GO:0009231] riboflavin synthase activity [GO:0004746] GO:0004746; GO:0005829; GO:0009231 +P0AC81 LGUL_ECOLI Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) gloA b1651 JW1643 gloA 14,920 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]; response to toxic substance [GO:0009636] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; lactoylglutathione lyase activity [GO:0004462]; nickel cation binding [GO:0016151]; methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]; response to toxic substance [GO:0009636] lactoylglutathione lyase activity [GO:0004462]; nickel cation binding [GO:0016151] GO:0004462; GO:0005737; GO:0005829; GO:0009636; GO:0016151; GO:0019243 +P0AB58 LAPB_ECOLI Lipopolysaccharide assembly protein B (Lipopolysaccharide regulatory protein) lapB yciM b1280 JW1272 yciM lapB 44,531 cell division [GO:0051301]; lipopolysaccharide metabolic process [GO:0008653]; regulation of lipid biosynthetic process [GO:0046890] cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; intrinsic component of the cytoplasmic side of the plasma membrane [GO:0031235] cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; intrinsic component of the cytoplasmic side of the plasma membrane [GO:0031235]; iron ion binding [GO:0005506]; metal ion binding [GO:0046872]; cell division [GO:0051301]; lipopolysaccharide metabolic process [GO:0008653]; regulation of lipid biosynthetic process [GO:0046890] iron ion binding [GO:0005506]; metal ion binding [GO:0046872] GO:0005506; GO:0005829; GO:0005887; GO:0008653; GO:0031235; GO:0046872; GO:0046890; GO:0051301 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00994, ECO:0000269|PubMed:24187084, ECO:0000269|PubMed:24722986}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00994, ECO:0000269|PubMed:24187084}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_00994, ECO:0000269|PubMed:24187084}. +P0ADC1 LPTE_ECOLI LPS-assembly lipoprotein LptE (Rare lipoprotein B) lptE rlpB b0641 JW0636 rlpB lptE 21,357 Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; lipopolysaccharide transport [GO:0015920] cell outer membrane [GO:0009279]; transporter complex [GO:1990351] cell outer membrane [GO:0009279]; transporter complex [GO:1990351]; lipopolysaccharide binding [GO:0001530]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; lipopolysaccharide transport [GO:0015920] lipopolysaccharide binding [GO:0001530] GO:0001530; GO:0009279; GO:0015920; GO:0043165; GO:1990351 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_01186, ECO:0000269|PubMed:20446753, ECO:0000269|PubMed:21257904, ECO:0000269|PubMed:3316191}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_01186, ECO:0000269|PubMed:20446753, ECO:0000269|PubMed:21257904, ECO:0000269|PubMed:3316191}. Note=A substantial portion is found inside the LptD beta-barrel. +P28697 MBIA_ECOLI Uncharacterized protein MbiA (Modifier of biofilm) mbiA htgA htpY b0012 JW5001 htgA htpY mbiA 17,637 +P0AFV4 MEPS_ECOLI Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase (EC 3.4.-.-) (EC 3.4.17.13) (Lipoprotein Spr) (Murein hydrolase MepS) mepS spr yeiV b2175 JW2163 spr yeiV mepS 21,040 capsule polysaccharide biosynthetic process [GO:0045227]; cell wall organization [GO:0071555]; peptidoglycan metabolic process [GO:0000270]; peptidoglycan turnover [GO:0009254] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; cysteine-type peptidase activity [GO:0008234]; endopeptidase activity [GO:0004175]; capsule polysaccharide biosynthetic process [GO:0045227]; cell wall organization [GO:0071555]; peptidoglycan metabolic process [GO:0000270]; peptidoglycan turnover [GO:0009254] cysteine-type peptidase activity [GO:0008234]; endopeptidase activity [GO:0004175] GO:0000270; GO:0004175; GO:0008234; GO:0009254; GO:0009279; GO:0045227; GO:0071555 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +A5A616 MGTS_ECOLI Small protein MgtS mgtS yneM b4599 JW1527.1 yneM mgtS 3,509 cellular response to magnesium starvation [GO:0010350] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cellular response to magnesium starvation [GO:0010350] GO:0005886; GO:0010350; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:21778229, ECO:0000305|PubMed:19121005}; Single-pass membrane protein {ECO:0000269|PubMed:21778229}. +P0AFC0 NUDB_ECOLI Dihydroneopterin triphosphate diphosphatase (EC 3.6.1.67) (Dihydroneopterin triphosphate pyrophosphatase) (dATP pyrophosphohydrolase) nudB ntpA b1865 JW1854 ntpA nudB 17,306 folic acid biosynthetic process [GO:0046656]; tetrahydrofolate biosynthetic process [GO:0046654] dATP pyrophosphohydrolase activity [GO:0008828]; dihydroneopterin triphosphate pyrophosphohydrolase activity [GO:0019177]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; folic acid biosynthetic process [GO:0046656]; tetrahydrofolate biosynthetic process [GO:0046654] dATP pyrophosphohydrolase activity [GO:0008828]; dihydroneopterin triphosphate pyrophosphohydrolase activity [GO:0019177]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872] GO:0000287; GO:0008828; GO:0019177; GO:0046654; GO:0046656; GO:0046872 +P77150 PDXY_ECOLI Pyridoxal kinase PdxY (PL kinase) (EC 2.7.1.35) (Pyridoxal kinase 2) (PL kinase 2) pdxY ydgS b1636 JW1628 ydgS pdxY 31,322 pyridoxal 5'-phosphate salvage [GO:0009443]; pyridoxal metabolic process [GO:0042817]; vitamin B6 biosynthetic process [GO:0042819] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; pyridoxal kinase activity [GO:0008478]; pyridoxal 5'-phosphate salvage [GO:0009443]; pyridoxal metabolic process [GO:0042817]; vitamin B6 biosynthetic process [GO:0042819] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; pyridoxal kinase activity [GO:0008478] GO:0000287; GO:0005524; GO:0005829; GO:0008478; GO:0009443; GO:0042802; GO:0042817; GO:0042819 +P0A924 PGPB_ECOLI Phosphatidylglycerophosphatase B (EC 3.1.3.27) (Diacylglycerol pyrophosphate phosphatase) (DGPP phosphatase) (EC 3.1.3.81) (Phosphatidate phosphatase) (EC 3.1.3.4) (Undecaprenyl pyrophosphate phosphatase) (EC 3.6.1.27) (Undecaprenyl-diphosphatase) pgpB b1278 JW1270 pgpB 29,021 glycerophospholipid biosynthetic process [GO:0046474]; peptidoglycan biosynthetic process [GO:0009252]; phosphatidylglycerol biosynthetic process [GO:0006655]; phospholipid catabolic process [GO:0009395] cell outer membrane [GO:0009279]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cell outer membrane [GO:0009279]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; diacylglycerol diphosphate phosphatase activity [GO:0000810]; phosphatidate phosphatase activity [GO:0008195]; phosphatidylglycerophosphatase activity [GO:0008962]; undecaprenyl-diphosphatase activity [GO:0050380]; glycerophospholipid biosynthetic process [GO:0046474]; peptidoglycan biosynthetic process [GO:0009252]; phosphatidylglycerol biosynthetic process [GO:0006655]; phospholipid catabolic process [GO:0009395] diacylglycerol diphosphate phosphatase activity [GO:0000810]; phosphatidate phosphatase activity [GO:0008195]; phosphatidylglycerophosphatase activity [GO:0008962]; undecaprenyl-diphosphatase activity [GO:0050380] GO:0000810; GO:0005886; GO:0005887; GO:0006655; GO:0008195; GO:0008962; GO:0009252; GO:0009279; GO:0009395; GO:0046474; GO:0050380 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. Cell outer membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P69783 PTGA_ECOLI PTS system glucose-specific EIIA component (EIIA-Glc) (EIII-Glc) (Glucose-specific phosphotransferase enzyme IIA component) crr gsr iex tgs treD b2417 JW2410 gsr iex tgs treD crr 18,251 negative regulation of carbohydrate metabolic process [GO:0045912]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; membrane [GO:0016020] cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; membrane [GO:0016020]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; negative regulation of carbohydrate metabolic process [GO:0045912]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; metal ion binding [GO:0046872] GO:0005829; GO:0009401; GO:0016020; GO:0016301; GO:0031234; GO:0045912; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AG34 RHTB_ECOLI Homoserine/homoserine lactone efflux protein rhtB yigK b3824 JW5585 yigK rhtB 22,427 amino acid transport [GO:0006865]; homoserine transport [GO:0042968]; threonine transport [GO:0015826] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; homoserine transmembrane transporter activity [GO:0042970]; threonine efflux transmembrane transporter activity [GO:0015565]; amino acid transport [GO:0006865]; homoserine transport [GO:0042968]; threonine transport [GO:0015826] amino acid transmembrane transporter activity [GO:0015171]; homoserine transmembrane transporter activity [GO:0042970]; threonine efflux transmembrane transporter activity [GO:0015565] GO:0005886; GO:0005887; GO:0006865; GO:0015171; GO:0015565; GO:0015826; GO:0042968; GO:0042970 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P31678 OTSB_ECOLI Trehalose-6-phosphate phosphatase (TPP) (EC 3.1.3.12) (Osmoregulatory trehalose synthesis protein B) (Trehalose 6-phosphate phosphatase) (Trehalose-phosphatase) otsB b1897 JW1886 otsB 29,175 response to osmotic stress [GO:0006970]; trehalose biosynthetic process [GO:0005992]; trehalose metabolism in response to cold stress [GO:0070415] magnesium ion binding [GO:0000287]; trehalose-phosphatase activity [GO:0004805]; response to osmotic stress [GO:0006970]; trehalose biosynthetic process [GO:0005992]; trehalose metabolism in response to cold stress [GO:0070415] magnesium ion binding [GO:0000287]; trehalose-phosphatase activity [GO:0004805] GO:0000287; GO:0004805; GO:0005992; GO:0006970; GO:0070415 +P0ABF1 PCNB_ECOLI Poly(A) polymerase I (PAP I) (EC 2.7.7.19) (Plasmid copy number protein) pcnB b0143 JW5808 pcnB 53,871 mRNA polyadenylation [GO:0006378]; mRNA processing [GO:0006397]; plasmid maintenance [GO:0006276]; RNA modification [GO:0009451] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; polynucleotide adenylyltransferase activity [GO:0004652]; RNA binding [GO:0003723]; mRNA polyadenylation [GO:0006378]; mRNA processing [GO:0006397]; plasmid maintenance [GO:0006276]; RNA modification [GO:0009451] ATP binding [GO:0005524]; polynucleotide adenylyltransferase activity [GO:0004652]; RNA binding [GO:0003723] GO:0003723; GO:0004652; GO:0005524; GO:0005737; GO:0005829; GO:0005886; GO:0006276; GO:0006378; GO:0006397; GO:0009451 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15737627}. Cell inner membrane {ECO:0000269|PubMed:15737627}. +P69805 PTND_ECOLI PTS system mannose-specific EIID component (EII-M-Man) (EIID-Man) (Mannose permease IID component) manZ gptB ptsM b1819 JW1808 gptB ptsM manZ 30,955 glucose import across plasma membrane [GO:0098708]; mannose transmembrane transport [GO:0015761]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity [GO:0022870]; glucose import across plasma membrane [GO:0098708]; mannose transmembrane transport [GO:0015761]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity [GO:0022870] GO:0005886; GO:0005887; GO:0009401; GO:0015761; GO:0016020; GO:0022870; GO:0098708 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:31209249, ECO:0000269|PubMed:8774730}; Multi-pass membrane protein {ECO:0000269|PubMed:31209249}. +P39315 QOR2_ECOLI Quinone oxidoreductase 2 (EC 1.6.5.2) qorB qor2 ytfG b4211 JW4169 qor2 ytfG qorB 29,734 cytosol [GO:0005829] cytosol [GO:0005829]; NADH dehydrogenase (quinone) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655] NADH dehydrogenase (quinone) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655] GO:0005829; GO:0008753; GO:0016655; GO:0050136 +P52129 RNLA_ECOLI mRNA endoribonuclease toxin LS (EC 3.1.-.-) (RNase LS) (Toxin LS) rnlA std yfjN b2630 JW2611 std yfjN rnlA 40,061 defense response to virus [GO:0051607]; mRNA catabolic process [GO:0006402] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; endoribonuclease activity [GO:0004521]; defense response to virus [GO:0051607]; mRNA catabolic process [GO:0006402] endoribonuclease activity [GO:0004521] GO:0004521; GO:0005737; GO:0006402; GO:0051607 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17895580}. Note=May associate with ribosomes, it sediments in a P100 fraction (pellet of a 100,000 x g centrifugation). {ECO:0000305|PubMed:17895580}. +P27431 ROXA_ECOLI 50S ribosomal protein L16 3-hydroxylase (EC 1.14.11.47) (Ribosomal oxygenase RoxA) (ROX) roxA ycfD b1128 JW1114 ycfD roxA 42,579 peptidyl-arginine hydroxylation [GO:0030961]; post-translational protein modification [GO:0043687] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; ferrous iron binding [GO:0008198]; peptidyl-arginine hydroxylation [GO:0030961]; post-translational protein modification [GO:0043687] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; ferrous iron binding [GO:0008198] GO:0008198; GO:0016706; GO:0030961; GO:0043687 +P76535 MURQ_ECOLI N-acetylmuramic acid 6-phosphate etherase (MurNAc-6-P etherase) (EC 4.2.1.126) (N-acetylmuramic acid 6-phosphate hydrolase) (N-acetylmuramic acid 6-phosphate lyase) murQ yfeU b2428 JW2421 yfeU murQ 31,220 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process [GO:0097175]; amino sugar catabolic process [GO:0046348]; carbohydrate metabolic process [GO:0005975]; N-acetylmuramic acid catabolic process [GO:0097173]; peptidoglycan turnover [GO:0009254] carbohydrate derivative binding [GO:0097367]; carbon-oxygen lyase activity [GO:0016835]; ether hydrolase activity [GO:0016803]; 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process [GO:0097175]; amino sugar catabolic process [GO:0046348]; carbohydrate metabolic process [GO:0005975]; N-acetylmuramic acid catabolic process [GO:0097173]; peptidoglycan turnover [GO:0009254] carbohydrate derivative binding [GO:0097367]; carbon-oxygen lyase activity [GO:0016835]; ether hydrolase activity [GO:0016803] GO:0005975; GO:0009254; GO:0016803; GO:0016835; GO:0046348; GO:0097173; GO:0097175; GO:0097367 +P0AF16 MURJ_ECOLI Lipid II flippase MurJ (Peptidoglycan biosynthesis protein MurJ) murJ mviN yceN b1069 JW1056 mviN yceN murJ 55,267 cell wall organization [GO:0071555]; glycolipid translocation [GO:0034203]; lipid-linked peptidoglycan transport [GO:0015836]; lipid translocation [GO:0034204]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] division septum [GO:0000935]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] division septum [GO:0000935]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cardiolipin binding [GO:1901612]; lipid-linked peptidoglycan transporter activity [GO:0015648]; cell wall organization [GO:0071555]; glycolipid translocation [GO:0034203]; lipid translocation [GO:0034204]; lipid-linked peptidoglycan transport [GO:0015836]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] cardiolipin binding [GO:1901612]; lipid-linked peptidoglycan transporter activity [GO:0015648] GO:0000935; GO:0005886; GO:0005887; GO:0008360; GO:0009252; GO:0015648; GO:0015836; GO:0034203; GO:0034204; GO:0071555; GO:1901612 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02078, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:23935042}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02078, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:23935042}. +P28903 NRDD_ECOLI Anaerobic ribonucleoside-triphosphate reductase (EC 1.1.98.6) (Class III ribonucleoside-triphosphate reductase) nrdD b4238 JW4197 nrdD 80,023 2'-deoxyribonucleotide biosynthetic process [GO:0009265]; DNA replication [GO:0006260]; nucleobase-containing small molecule interconversion [GO:0015949] anaerobic ribonucleoside-triphosphate reductase complex [GO:0031250] anaerobic ribonucleoside-triphosphate reductase complex [GO:0031250]; ATP binding [GO:0005524]; CTP reductase activity [GO:0051065]; dATP binding [GO:0032564]; dGTP binding [GO:0032567]; pyrimidine deoxyribonucleotide binding [GO:0032556]; ribonucleoside-triphosphate reductase activity [GO:0008998]; zinc ion binding [GO:0008270]; 2'-deoxyribonucleotide biosynthetic process [GO:0009265]; DNA replication [GO:0006260]; nucleobase-containing small molecule interconversion [GO:0015949] ATP binding [GO:0005524]; CTP reductase activity [GO:0051065]; dATP binding [GO:0032564]; dGTP binding [GO:0032567]; pyrimidine deoxyribonucleotide binding [GO:0032556]; ribonucleoside-triphosphate reductase activity [GO:0008998]; zinc ion binding [GO:0008270] GO:0005524; GO:0006260; GO:0008270; GO:0008998; GO:0009265; GO:0015949; GO:0031250; GO:0032556; GO:0032564; GO:0032567; GO:0051065 +P0AGI1 RBSC_ECOLI Ribose import permease protein RbsC rbsC b3750 JW3729 rbsC 33,452 D-ribose transmembrane transport [GO:0015752] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; D-ribose transmembrane transporter activity [GO:0015591]; D-ribose transmembrane transport [GO:0015752] D-ribose transmembrane transporter activity [GO:0015591] GO:0005886; GO:0005887; GO:0015591; GO:0015752; GO:0016021; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:9922273}; Multi-pass membrane protein {ECO:0000305|PubMed:9922273}. +P07012 RF2_ECOLI Peptide chain release factor RF2 (RF-2) prfB supK b2891 JW5847 supK prfB 41,251 translational termination [GO:0006415] cytosol [GO:0005829] cytosol [GO:0005829]; translation release factor activity, codon specific [GO:0016149]; translational termination [GO:0006415] translation release factor activity, codon specific [GO:0016149] GO:0005829; GO:0006415; GO:0016149 SUBCELLULAR LOCATION: Cytoplasm. Note=Recruited to the 70S ribosome by ArfA even in the absence of mRNA (PubMed:22922063, PubMed:25355516, PubMed:27934701). {ECO:0000269|PubMed:22922063, ECO:0000269|PubMed:25355516, ECO:0000269|PubMed:27934701}. +P0A944 RIMI_ECOLI [Ribosomal protein S18]-alanine N-acetyltransferase (EC 2.3.1.266) (KAT) (Peptidyl-lysine N-acetyltransferase) (EC 2.3.1.-) rimI b4373 JW4335 rimI 16,610 cellular protein modification process [GO:0006464]; internal peptidyl-lysine acetylation [GO:0018393]; N-terminal peptidyl-alanine acetylation [GO:0017189]; N-terminal protein amino acid acetylation [GO:0006474] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; N-acetyltransferase activity [GO:0008080]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; ribosomal-protein-alanine N-acetyltransferase activity [GO:0008999]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747]; cellular protein modification process [GO:0006464]; internal peptidyl-lysine acetylation [GO:0018393]; N-terminal peptidyl-alanine acetylation [GO:0017189]; N-terminal protein amino acid acetylation [GO:0006474] N-acetyltransferase activity [GO:0008080]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; ribosomal-protein-alanine N-acetyltransferase activity [GO:0008999]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] GO:0005737; GO:0006464; GO:0006474; GO:0008080; GO:0008999; GO:0016747; GO:0017189; GO:0018393; GO:0061733 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02210, ECO:0000305}. +P0AG44 RL17_ECOLI 50S ribosomal protein L17 (Large ribosomal subunit protein bL17) rplQ b3294 JW3256 rplQ 14,365 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934]; structural constituent of ribosome [GO:0003735]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] structural constituent of ribosome [GO:0003735] GO:0000027; GO:0003735; GO:0005829; GO:0006412; GO:0015934; GO:0022625 +P0ACG6 HOKD_ECOLI Toxic protein HokD (Protein RelF) hokD relF b1562 JW1554 relF hokD 5,737 cell death [GO:0008219] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cell death [GO:0008219] GO:0005886; GO:0008219; GO:0016020; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:P0ACG4, ECO:0000305|PubMed:3019679}; Single-pass membrane protein {ECO:0000250|UniProtKB:P0ACG4}. +P04968 ILVA_ECOLI L-threonine dehydratase biosynthetic IlvA (EC 4.3.1.19) (Threonine deaminase) ilvA b3772 JW3745 ilvA 56,195 branched-chain amino acid biosynthetic process [GO:0009082]; cellular amino acid biosynthetic process [GO:0008652]; isoleucine biosynthetic process [GO:0009097]; threonine catabolic process [GO:0006567]; threonine metabolic process [GO:0006566] amino acid binding [GO:0016597]; L-threonine ammonia-lyase activity [GO:0004794]; pyridoxal phosphate binding [GO:0030170]; branched-chain amino acid biosynthetic process [GO:0009082]; cellular amino acid biosynthetic process [GO:0008652]; isoleucine biosynthetic process [GO:0009097]; threonine catabolic process [GO:0006567]; threonine metabolic process [GO:0006566] amino acid binding [GO:0016597]; L-threonine ammonia-lyase activity [GO:0004794]; pyridoxal phosphate binding [GO:0030170] GO:0004794; GO:0006566; GO:0006567; GO:0008652; GO:0009082; GO:0009097; GO:0016597; GO:0030170 +P0ADV7 MLAC_ECOLI Intermembrane phospholipid transport system binding protein MlaC mlaC yrbC b3192 JW3159 yrbC mlaC 23,963 intermembrane phospholipid transfer [GO:0120010]; phospholipid transport [GO:0015914] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; intermembrane phospholipid transfer [GO:0120010]; phospholipid transport [GO:0015914] GO:0015914; GO:0030288; GO:0120010 SUBCELLULAR LOCATION: Periplasm {ECO:0000305|PubMed:19383799}. +P16691 PHNO_ECOLI Aminoalkylphosphonate N-acetyltransferase (EC 2.3.1.280) (KAT) (Peptidyl-lysine N-acetyltransferase) (EC 2.3.1.-) phnO b4093 JW4054 phnO 16,570 aminophosphonate metabolic process [GO:0033051]; internal peptidyl-lysine acetylation [GO:0018393] N-acetyltransferase activity [GO:0008080]; peptide-lysine-N-acetyltransferase activity [GO:0061733]; aminophosphonate metabolic process [GO:0033051]; internal peptidyl-lysine acetylation [GO:0018393] N-acetyltransferase activity [GO:0008080]; peptide-lysine-N-acetyltransferase activity [GO:0061733] GO:0008080; GO:0018393; GO:0033051; GO:0061733 +P63177 RLMB_ECOLI 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB (EC 2.1.1.185) (23S rRNA (guanosine2251 2'-O)-methyltransferase) (23S rRNA Gm2251 2'-O-methyltransferase) rlmB yjfH b4180 JW4138 yjfH rlmB 26,557 enzyme-directed rRNA 2'-O-methylation [GO:0000453]; RNA methylation [GO:0001510] cytosol [GO:0005829] cytosol [GO:0005829]; RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173]; rRNA (guanosine-2'-O-)-methyltransferase activity [GO:0070039]; enzyme-directed rRNA 2'-O-methylation [GO:0000453]; RNA methylation [GO:0001510] RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173]; rRNA (guanosine-2'-O-)-methyltransferase activity [GO:0070039] GO:0000453; GO:0001510; GO:0003723; GO:0005829; GO:0008173; GO:0070039 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P60438 RL3_ECOLI 50S ribosomal protein L3 (Large ribosomal subunit protein uL3) rplC b3320 JW3282 rplC 22,244 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GO:0000027; GO:0003735; GO:0005829; GO:0006412; GO:0019843; GO:0022625 +P0A7U3 RS19_ECOLI 30S ribosomal protein S19 (Small ribosomal subunit protein uS19) rpsS b3316 JW3278 rpsS 10,430 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049] GO:0000028; GO:0000049; GO:0003735; GO:0005829; GO:0006412; GO:0019843; GO:0022627 +P64604 MLAD_ECOLI Intermembrane phospholipid transport system binding protein MlaD mlaD yrbD b3193 JW3160 yrbD mlaD 19,576 integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; phospholipid binding [GO:0005543]; phospholipid transporter activity [GO:0005548] phospholipid binding [GO:0005543]; phospholipid transporter activity [GO:0005548] GO:0005543; GO:0005548; GO:0005886; GO:0005887; GO:0030288; GO:0032991 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:19383799}; Single-pass type II membrane protein {ECO:0000305|PubMed:19383799}; Periplasmic side {ECO:0000305|PubMed:19383799}. +P11880 MURF_ECOLI UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (EC 6.3.2.10) (D-alanyl-D-alanine-adding enzyme) (UDP-MurNAc-pentapeptide synthetase) murF mra b0086 JW0084 mra murF 47,447 cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity [GO:0047480]; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity [GO:0008766]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] ATP binding [GO:0005524]; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity [GO:0008766]; UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity [GO:0047480] GO:0005524; GO:0005829; GO:0007049; GO:0008360; GO:0008766; GO:0009252; GO:0047480; GO:0051301; GO:0071555 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02019, ECO:0000269|PubMed:2186811}. +P21369 PNCA_ECOLI Nicotinamidase (EC 3.5.1.19) (Nicotinamide deamidase) (NAMase) (Pyrazinamidase) (PZAase) (EC 3.5.1.-) pncA nam ydjB b1768 JW1757 nam ydjB pncA 23,362 pyridine nucleotide salvage [GO:0019365] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; metal ion binding [GO:0046872]; nicotinamidase activity [GO:0008936]; pyridine nucleotide salvage [GO:0019365] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; metal ion binding [GO:0046872]; nicotinamidase activity [GO:0008936] GO:0008936; GO:0016811; GO:0019365; GO:0046872 +P77541 PRPB_ECOLI 2-methylisocitrate lyase (2-MIC) (MICL) (EC 4.1.3.30) ((2R,3S)-2-methylisocitrate lyase) prpB yahQ b0331 JW0323 yahQ prpB 32,135 propionate catabolic process, 2-methylcitrate cycle [GO:0019629] magnesium ion binding [GO:0000287]; methylisocitrate lyase activity [GO:0046421]; propionate catabolic process, 2-methylcitrate cycle [GO:0019629] magnesium ion binding [GO:0000287]; methylisocitrate lyase activity [GO:0046421] GO:0000287; GO:0019629; GO:0046421 +P31828 PQQL_ECOLI Probable zinc protease PqqL (EC 3.4.24.-) pqqL yddC b1494 JW1489 yddC pqqL 104,656 cytosol [GO:0005829] cytosol [GO:0005829]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] GO:0005829; GO:0008237; GO:0046872 +P77439 PTFX1_ECOLI Multiphosphoryl transfer protein 1 (MTP 1) (Triphosphoryl transfer protein 1) (TTP 1) [Includes: Phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) (Phosphotransferase system enzyme I); Phosphocarrier protein HPr (Protein H); PTS system fructose-like EIIA component (EC 2.7.1.202) (Fructose-like phosphotransferase enzyme IIA component)] fryA ypdD b2383 JW2380 ypdD fryA 92,130 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737]; integral component of membrane [GO:0016021] cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphoenolpyruvate-protein phosphotransferase activity [GO:0008965]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphoenolpyruvate-protein phosphotransferase activity [GO:0008965]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982] GO:0005737; GO:0008965; GO:0008982; GO:0009401; GO:0016021; GO:0016301; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P42904 PTPB2_ECOLI N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 2 (EC 2.7.1.-) (EIIB-Aga') (PTS system N-acetylgalactosamine-specific EIIB component 2) agaV yhaY b3133 JW3102 yhaY agaV 17,086 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982] GO:0005737; GO:0008982; GO:0009401; GO:0016301 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P08178 PUR5_ECOLI Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) purM purG b2499 JW2484 purG purM 36,854 'de novo' IMP biosynthetic process [GO:0006189]; adenine biosynthetic process [GO:0046084]; purine nucleotide biosynthetic process [GO:0006164] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; phosphoribosylamine-glycine ligase activity [GO:0004637]; phosphoribosylformylglycinamidine cyclo-ligase activity [GO:0004641]; 'de novo' IMP biosynthetic process [GO:0006189]; adenine biosynthetic process [GO:0046084]; purine nucleotide biosynthetic process [GO:0006164] ATP binding [GO:0005524]; phosphoribosylamine-glycine ligase activity [GO:0004637]; phosphoribosylformylglycinamidine cyclo-ligase activity [GO:0004641] GO:0004637; GO:0004641; GO:0005524; GO:0005829; GO:0006164; GO:0006189; GO:0046084 SUBCELLULAR LOCATION: Cytoplasm. +P0AG18 PURE_ECOLI N5-carboxyaminoimidazole ribonucleotide mutase (N5-CAIR mutase) (EC 5.4.99.18) (5-(carboxyamino)imidazole ribonucleotide mutase) purE b0523 JW0512 purE 17,780 'de novo' IMP biosynthetic process [GO:0006189] cytosol [GO:0005829] cytosol [GO:0005829]; 5-(carboxyamino)imidazole ribonucleotide mutase activity [GO:0034023]; identical protein binding [GO:0042802]; 'de novo' IMP biosynthetic process [GO:0006189] 5-(carboxyamino)imidazole ribonucleotide mutase activity [GO:0034023]; identical protein binding [GO:0042802] GO:0005829; GO:0006189; GO:0034023; GO:0042802 +P33229 RALR_ECOLI Endodeoxyribonuclease toxin RalR (DNase RalR) (EC 3.1.-.-) (Restriction alleviation and modification enhancement protein) (Toxin RalR) ralR lar ral ydaB b1348 JW5208 lar ral ydaB ralR 7,019 DNA restriction-modification system [GO:0009307]; response to antibiotic [GO:0046677] double-stranded DNA endodeoxyribonuclease activity [GO:1990238]; DNA restriction-modification system [GO:0009307]; response to antibiotic [GO:0046677] double-stranded DNA endodeoxyribonuclease activity [GO:1990238] GO:0009307; GO:0046677; GO:1990238 +P0A7K6 RL19_ECOLI 50S ribosomal protein L19 (Large ribosomal subunit protein bL19) rplS b2606 JW2587 rplS 13,133 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735] GO:0000027; GO:0003735; GO:0005829; GO:0006412; GO:0022625; GO:0070180 +P0A7M9 RL31_ECOLI 50S ribosomal protein L31 (Large ribosomal subunit protein bL31-A) rpmE b3936 JW3907 rpmE 7,871 translation [GO:0006412]; translational initiation [GO:0006413] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; zinc ion binding [GO:0008270]; translation [GO:0006412]; translational initiation [GO:0006413] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; zinc ion binding [GO:0008270] GO:0003735; GO:0005829; GO:0006412; GO:0006413; GO:0008270; GO:0019843; GO:0022625 +P37760 RMLD_ECOLI dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) (dTDP-4-keto-L-rhamnose reductase) (dTDP-6-deoxy-L-lyxo-4-hexulose reductase) (dTDP-6-deoxy-L-mannose dehydrogenase) (dTDP-L-rhamnose synthase) rfbD rmlD b2040 JW2025 rmlD rfbD 32,694 dTDP-rhamnose biosynthetic process [GO:0019305]; extracellular polysaccharide biosynthetic process [GO:0045226]; lipopolysaccharide biosynthetic process [GO:0009103]; O antigen biosynthetic process [GO:0009243] cytosol [GO:0005829] cytosol [GO:0005829]; dTDP-4-dehydrorhamnose reductase activity [GO:0008831]; metal ion binding [GO:0046872]; dTDP-rhamnose biosynthetic process [GO:0019305]; extracellular polysaccharide biosynthetic process [GO:0045226]; lipopolysaccharide biosynthetic process [GO:0009103]; O antigen biosynthetic process [GO:0009243] dTDP-4-dehydrorhamnose reductase activity [GO:0008831]; metal ion binding [GO:0046872] GO:0005829; GO:0008831; GO:0009103; GO:0009243; GO:0019305; GO:0045226; GO:0046872 +P30014 RNT_ECOLI Ribonuclease T (EC 3.1.13.-) (Exoribonuclease T) (RNase T) rnt b1652 JW1644 rnt 23,523 DNA replication proofreading [GO:0045004]; tRNA 3'-end processing [GO:0042780] cytosol [GO:0005829] cytosol [GO:0005829]; 3'-5' exonuclease activity [GO:0008408]; exoribonuclease activity, producing 5'-phosphomonoesters [GO:0016896]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]; DNA replication proofreading [GO:0045004]; tRNA 3'-end processing [GO:0042780] 3'-5' exonuclease activity [GO:0008408]; exoribonuclease activity, producing 5'-phosphomonoesters [GO:0016896]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676] GO:0000287; GO:0003676; GO:0005829; GO:0008408; GO:0016896; GO:0042780; GO:0042802; GO:0045004 +P17334 PTQC_ECOLI PTS system N,N'-diacetylchitobiose-specific EIIC component (EIIC-Chb) (IIcel) (N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIC component) chbC celB b1737 JW1726 celB chbC 48,332 carbohydrate derivative transport [GO:1901264]; N,N'-diacetylchitobiose import [GO:1902815]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; carbohydrate derivative transport [GO:1901264]; N,N'-diacetylchitobiose import [GO:1902815]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982] GO:0005886; GO:0008982; GO:0009401; GO:0016021; GO:1901264; GO:1902815 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00428}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00428}. +P0A7G2 RBFA_ECOLI 30S ribosome-binding factor (Protein P15B) (Ribosome-binding factor A) (RbfA) rbfA P15B yhbB b3167 JW3136 P15B yhbB rbfA 15,154 cellular response to DNA damage stimulus [GO:0006974]; maturation of SSU-rRNA [GO:0030490]; response to cold [GO:0009409]; ribosome biogenesis [GO:0042254] cytosol [GO:0005829] cytosol [GO:0005829]; ribosomal small subunit binding [GO:0043024]; cellular response to DNA damage stimulus [GO:0006974]; maturation of SSU-rRNA [GO:0030490]; response to cold [GO:0009409]; ribosome biogenesis [GO:0042254] ribosomal small subunit binding [GO:0043024] GO:0005829; GO:0006974; GO:0009409; GO:0030490; GO:0042254; GO:0043024 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00003, ECO:0000269|PubMed:12963368, ECO:0000269|PubMed:7535280}. Note=About 1/3 associates with free 30S ribosomal subunits at 37 degrees Celsius, 6 hours after a 15 degrees Celsius cold-shock about 4-fold more protein is associated with 30S ribosomes (PubMed:7535280, PubMed:12963368). {ECO:0000269|PubMed:12963368, ECO:0000269|PubMed:7535280}. +P24554 RADA_ECOLI DNA repair protein RadA (EC 3.6.4.-) (Branch migration protein RadA) (DNA repair protein Sms) radA sms b4389 JW4352 sms radA 49,472 DNA repair [GO:0006281]; recombinational repair [GO:0000725]; response to radiation [GO:0009314] ATP binding [GO:0005524]; ATPase activity, acting on DNA [GO:0008094]; damaged DNA binding [GO:0003684]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]; DNA repair [GO:0006281]; recombinational repair [GO:0000725]; response to radiation [GO:0009314] ATPase activity, acting on DNA [GO:0008094]; ATP binding [GO:0005524]; damaged DNA binding [GO:0003684]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697] GO:0000725; GO:0003684; GO:0003697; GO:0005524; GO:0006281; GO:0008094; GO:0009314; GO:0046872 +P27240 RFAY_ECOLI Lipopolysaccharide core heptose(II) kinase RfaY (EC 2.7.1.-) rfaY waaY b3625 JW3600 waaY rfaY 27,461 carbohydrate phosphorylation [GO:0046835]; lipopolysaccharide core region biosynthetic process [GO:0009244] ATP binding [GO:0005524]; kinase activity [GO:0016301]; carbohydrate phosphorylation [GO:0046835]; lipopolysaccharide core region biosynthetic process [GO:0009244] ATP binding [GO:0005524]; kinase activity [GO:0016301] GO:0005524; GO:0009244; GO:0016301; GO:0046835 +P60723 RL4_ECOLI 50S ribosomal protein L4 (Large ribosomal subunit protein uL4) rplD eryA b3319 JW3281 eryA rplD 22,087 DNA-templated transcription, termination [GO:0006353]; negative regulation of endoribonuclease activity [GO:0060702]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation [GO:0017148]; response to antibiotic [GO:0046677]; ribosome assembly [GO:0042255]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934]; polysomal ribosome [GO:0042788] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934]; polysomal ribosome [GO:0042788]; endoribonuclease inhibitor activity [GO:0060698]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; translation repressor activity [GO:0030371]; DNA-templated transcription, termination [GO:0006353]; negative regulation of endoribonuclease activity [GO:0060702]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation [GO:0017148]; response to antibiotic [GO:0046677]; ribosome assembly [GO:0042255]; translation [GO:0006412] endoribonuclease inhibitor activity [GO:0060698]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; translation repressor activity [GO:0030371] GO:0003735; GO:0005829; GO:0006353; GO:0006412; GO:0015934; GO:0017148; GO:0019843; GO:0022625; GO:0030371; GO:0042255; GO:0042788; GO:0045892; GO:0046677; GO:0060698; GO:0060702 +P37765 RLUB_ECOLI Ribosomal large subunit pseudouridine synthase B (EC 5.4.99.22) (23S rRNA pseudouridine(2605) synthase) (rRNA pseudouridylate synthase B) (rRNA-uridine isomerase B) rluB yciL b1269 JW1261 yciL rluB 32,711 enzyme-directed rRNA pseudouridine synthesis [GO:0000455] cytosol [GO:0005829] cytosol [GO:0005829]; RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159]; enzyme-directed rRNA pseudouridine synthesis [GO:0000455] RNA binding [GO:0003723]; rRNA pseudouridine synthase activity [GO:0120159] GO:0000455; GO:0003723; GO:0005829; GO:0120159 +P0A9J0 RNG_ECOLI Ribonuclease G (RNase G) (EC 3.1.26.-) (Cytoplasmic axial filament protein) rng cafA orfF yhdF b3247 JW3216 cafA orfF yhdF rng 55,364 cell cycle [GO:0007049]; cell division [GO:0051301]; rRNA processing [GO:0006364]; tRNA processing [GO:0008033] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; plasma membrane [GO:0005886]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; ribonuclease activity [GO:0004540]; ribonuclease G activity [GO:0008996]; rRNA binding [GO:0019843]; tRNA binding [GO:0000049]; cell cycle [GO:0007049]; cell division [GO:0051301]; rRNA processing [GO:0006364]; tRNA processing [GO:0008033] endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; ribonuclease activity [GO:0004540]; ribonuclease G activity [GO:0008996]; rRNA binding [GO:0019843]; tRNA binding [GO:0000049] GO:0000049; GO:0004519; GO:0004540; GO:0005737; GO:0005856; GO:0005886; GO:0006364; GO:0007049; GO:0008033; GO:0008996; GO:0019843; GO:0046872; GO:0051301 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22509045, ECO:0000305|PubMed:14622423}. Cell inner membrane {ECO:0000269|PubMed:22509045}; Peripheral membrane protein {ECO:0000305|PubMed:22509045}. Cytoplasm, cytoskeleton {ECO:0000303|PubMed:8300545}. Note=Possible cytoskeletal location is upon overproduction. {ECO:0000303|PubMed:8300545}. +P28904 TREC_ECOLI Trehalose-6-phosphate hydrolase (EC 3.2.1.93) (Alpha,alpha-phosphotrehalase) treC olgH b4239 JW4198 olgH treC 63,838 cellular response to DNA damage stimulus [GO:0006974]; oligosaccharide catabolic process [GO:0009313]; trehalose catabolic process [GO:0005993] cytosol [GO:0005829] cytosol [GO:0005829]; alpha,alpha-phosphotrehalase activity [GO:0008788]; alpha-amylase activity [GO:0004556]; cellular response to DNA damage stimulus [GO:0006974]; oligosaccharide catabolic process [GO:0009313]; trehalose catabolic process [GO:0005993] alpha,alpha-phosphotrehalase activity [GO:0008788]; alpha-amylase activity [GO:0004556] GO:0004556; GO:0005829; GO:0005993; GO:0006974; GO:0008788; GO:0009313 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:8083158}. +P21888 SYC_ECOLI Cysteine--tRNA ligase (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS) cysS b0526 JW0515 cysS 52,202 cysteinyl-tRNA aminoacylation [GO:0006423] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; aminoacyl-tRNA ligase activity [GO:0004812]; ATP binding [GO:0005524]; cysteine-tRNA ligase activity [GO:0004817]; ligase activity [GO:0016874]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]; cysteinyl-tRNA aminoacylation [GO:0006423] aminoacyl-tRNA ligase activity [GO:0004812]; ATP binding [GO:0005524]; cysteine-tRNA ligase activity [GO:0004817]; ligase activity [GO:0016874]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] GO:0004812; GO:0004817; GO:0005524; GO:0005737; GO:0005829; GO:0006423; GO:0008270; GO:0016874; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm. +P0A8U0 SYDP_ECOLI Protein Syd syd ydr b2793 JW2764 ydr syd 20,708 regulation of protein-containing complex assembly [GO:0043254] cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234] cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; regulation of protein-containing complex assembly [GO:0043254] GO:0005737; GO:0031234; GO:0043254 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY. +P69425 TATB_ECOLI Sec-independent protein translocase protein TatB tatB mttA2 ysgB b3838 JW5580 mttA2 ysgB tatB 18,421 intracellular protein transmembrane transport [GO:0065002]; protein transport by the Tat complex [GO:0043953] integral component of plasma membrane [GO:0005887]; TAT protein transport complex [GO:0033281] integral component of plasma membrane [GO:0005887]; TAT protein transport complex [GO:0033281]; identical protein binding [GO:0042802]; proton motive force dependent protein transmembrane transporter activity [GO:0009977]; intracellular protein transmembrane transport [GO:0065002]; protein transport by the Tat complex [GO:0043953] identical protein binding [GO:0042802]; proton motive force dependent protein transmembrane transporter activity [GO:0009977] GO:0005887; GO:0009977; GO:0033281; GO:0042802; GO:0043953; GO:0065002 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00237, ECO:0000269|PubMed:11591389, ECO:0000269|PubMed:15225613, ECO:0000269|PubMed:20169075}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00237, ECO:0000269|PubMed:11591389, ECO:0000269|PubMed:15225613, ECO:0000269|PubMed:20169075}. Note=Localizes at the cell poles. +P0A9T4 TAS_ECOLI Protein tas tas ygdS b2834 JW2802 ygdS tas 38,500 cellular response to amino acid starvation [GO:0034198] cytosol [GO:0005829] cytosol [GO:0005829]; aldo-keto reductase (NADP) activity [GO:0004033]; D-threo-aldose 1-dehydrogenase activity [GO:0047834]; cellular response to amino acid starvation [GO:0034198] aldo-keto reductase (NADP) activity [GO:0004033]; D-threo-aldose 1-dehydrogenase activity [GO:0047834] GO:0004033; GO:0005829; GO:0034198; GO:0047834 +P0AGG0 THIL_ECOLI Thiamine-monophosphate kinase (TMP kinase) (Thiamine-phosphate kinase) (EC 2.7.4.16) thiL b0417 JW0407 thiL 35,071 thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; thiamine-phosphate kinase activity [GO:0009030]; thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; thiamine-phosphate kinase activity [GO:0009030] GO:0000287; GO:0005524; GO:0009030; GO:0009228; GO:0009229; GO:0046872 +P0ADE4 TAMA_ECOLI Translocation and assembly module subunit TamA (Autotransporter assembly factor TamA) tamA yftM ytfM b4220 JW4179 yftM ytfM tamA 64,796 protein localization to outer membrane [GO:0089705]; protein secretion [GO:0009306] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; TAM protein secretion complex [GO:0097347] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; TAM protein secretion complex [GO:0097347]; protein localization to outer membrane [GO:0089705]; protein secretion [GO:0009306] GO:0009279; GO:0009306; GO:0045203; GO:0089705; GO:0097347 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:16522795, ECO:0000269|PubMed:17214547, ECO:0000269|PubMed:22466966, ECO:0000269|PubMed:25341963}. +P0AG11 UMUD_ECOLI Protein UmuD (EC 3.4.21.-) (DNA polymerase V) (Pol V) [Cleaved into: Protein UmuD'] umuD b1183 JW1172 umuD 15,063 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; SOS response [GO:0009432]; translesion synthesis [GO:0019985] DNA polymerase V complex [GO:0009355] DNA polymerase V complex [GO:0009355]; ATPase activity, acting on DNA [GO:0008094]; DNA-directed DNA polymerase activity [GO:0003887]; identical protein binding [GO:0042802]; serine-type peptidase activity [GO:0008236]; single-stranded DNA binding [GO:0003697]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; SOS response [GO:0009432]; translesion synthesis [GO:0019985] ATPase activity, acting on DNA [GO:0008094]; DNA-directed DNA polymerase activity [GO:0003887]; identical protein binding [GO:0042802]; serine-type peptidase activity [GO:0008236]; single-stranded DNA binding [GO:0003697] GO:0003697; GO:0003887; GO:0006281; GO:0006355; GO:0006974; GO:0008094; GO:0008236; GO:0009355; GO:0009432; GO:0019985; GO:0042802 +P0A887 UBIE_ECOLI Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE (EC 2.1.1.163) (EC 2.1.1.201) (2-methoxy-6-polyprenyl-1,4-benzoquinol methylase) (Demethylmenaquinone methyltransferase) ubiE yigO b3833 JW5581 yigO ubiE 28,073 aerobic respiration [GO:0009060]; menaquinone biosynthetic process [GO:0009234]; methylation [GO:0032259]; ubiquinone biosynthetic process [GO:0006744] cytoplasm [GO:0005737]; ubiquinone biosynthesis complex [GO:0110142] cytoplasm [GO:0005737]; ubiquinone biosynthesis complex [GO:0110142]; 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity [GO:0043333]; demethylmenaquinone methyltransferase activity [GO:0043770]; methyltransferase activity [GO:0008168]; quinone cofactor methyltransferase activity [GO:0030580]; S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity [GO:0102094]; S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity [GO:0102955]; S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity [GO:0102027]; aerobic respiration [GO:0009060]; menaquinone biosynthetic process [GO:0009234]; methylation [GO:0032259]; ubiquinone biosynthetic process [GO:0006744] 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity [GO:0043333]; demethylmenaquinone methyltransferase activity [GO:0043770]; methyltransferase activity [GO:0008168]; quinone cofactor methyltransferase activity [GO:0030580]; S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity [GO:0102955]; S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity [GO:0102094]; S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity [GO:0102027] GO:0005737; GO:0006744; GO:0008168; GO:0009060; GO:0009234; GO:0030580; GO:0032259; GO:0043333; GO:0043770; GO:0102027; GO:0102094; GO:0102955; GO:0110142 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30686758}. +P37750 WBBJ_ECOLI Putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ (EC 2.3.1.-) wbbJ yefH b2033 JW2018 yefH wbbJ 21,675 lipopolysaccharide biosynthetic process [GO:0009103] cytosol [GO:0005829] cytosol [GO:0005829]; O-acyltransferase activity [GO:0008374]; lipopolysaccharide biosynthetic process [GO:0009103] O-acyltransferase activity [GO:0008374] GO:0005829; GO:0008374; GO:0009103 +P75749 YBGP_ECOLI Uncharacterized fimbrial chaperone YbgP ybgP b0717 JW0707 ybgP 26,954 cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711]; protein folding [GO:0006457] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711]; protein folding [GO:0006457] GO:0006457; GO:0030288; GO:0043711; GO:0061077; GO:0071555 SUBCELLULAR LOCATION: Periplasm {ECO:0000250}. +P75791 YBIU_ECOLI Uncharacterized protein YbiU ybiU b0821 JW0805 ybiU 47,329 +P40876 YCBF_ECOLI Uncharacterized fimbrial chaperone YcbF ycbF b0944 JW5124 ycbF 25,853 cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] GO:0030288; GO:0043711; GO:0061077; GO:0071555 SUBCELLULAR LOCATION: Periplasm {ECO:0000250}. +P77627 YBER_ECOLI Uncharacterized protein YbeR ybeR b0645 JW0640 ybeR 27,736 +Q47679 YAFV_ECOLI Omega-amidase YafV (EC 3.5.1.3) yafV b0219 JW5019 yafV 28,925 nitrogen compound metabolic process [GO:0006807] 2-oxoglutaramate amidase activity [GO:0106008]; omega-amidase activity [GO:0050152]; nitrogen compound metabolic process [GO:0006807] 2-oxoglutaramate amidase activity [GO:0106008]; omega-amidase activity [GO:0050152] GO:0006807; GO:0050152; GO:0106008 +P0AAT2 YBDF_ECOLI Uncharacterized protein YbdF ybdF b0579 JW5083 ybdF 14,050 +P64540 YFCL_ECOLI Uncharacterized protein YfcL yfcL b2325 JW2322 yfcL 10,000 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P76499 YFCP_ECOLI Uncharacterized fimbrial-like protein YfcP yfcP b2333 JW2330 yfcP 18,951 cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0007155; GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. +P0DPN3 YLCJ_ECOLI Protein YlcJ ylcJ b4733 ylcJ 5,943 +P77147 YDHT_ECOLI Uncharacterized protein YdhT ydhT b1669 JW1659 ydhT 29,341 +P0ACR7 YFER_ECOLI Uncharacterized HTH-type transcriptional regulator YfeR yfeR b2409 JW2400 yfeR 33,903 regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700] GO:0000986; GO:0003700; GO:0005829; GO:0006355 +P76484 YFBN_ECOLI Uncharacterized protein YfbN yfbN b2273 JW2268 yfbN 27,991 +Q46866 YGIV_ECOLI Probable transcriptional regulator YgiV ygiV b3023 JW5502 ygiV 17,827 negative regulation of transcription, DNA-templated [GO:0045892] negative regulation of transcription, DNA-templated [GO:0045892] GO:0045892 +Q46861 YGIQ_ECOLI UPF0313 protein YgiQ ygiQ ygiR b4469 JW5501 ygiR ygiQ 83,478 4 iron, 4 sulfur cluster binding [GO:0051539]; catalytic activity [GO:0003824]; iron ion binding [GO:0005506] 4 iron, 4 sulfur cluster binding [GO:0051539]; catalytic activity [GO:0003824]; iron ion binding [GO:0005506] GO:0003824; GO:0005506; GO:0051539 +P24197 YGID_ECOLI 4,5-DOPA dioxygenase extradiol (EC 1.13.11.29) ygiD b3039 JW3007 ygiD 29,903 cellular aromatic compound metabolic process [GO:0006725] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DOPA dioxygenase activity [GO:0046566]; ferrous iron binding [GO:0008198]; stizolobate synthase activity [GO:0050297]; zinc ion binding [GO:0008270]; cellular aromatic compound metabolic process [GO:0006725] DOPA dioxygenase activity [GO:0046566]; ferrous iron binding [GO:0008198]; stizolobate synthase activity [GO:0050297]; zinc ion binding [GO:0008270] GO:0005737; GO:0006725; GO:0008198; GO:0008270; GO:0046566; GO:0050297 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23666480}. +P32668 YIJF_ECOLI Uncharacterized protein YijF yijF b3944 JW3916 yijF 22,955 +Q7DFV4 YMDE_ECOLI Putative uncharacterized protein YmdE ymdE b1028 ymdE 12,008 transferase activity [GO:0016740] transferase activity [GO:0016740] GO:0016740 +P77538 YFHR_ECOLI Uncharacterized protein YfhR yfhR b2534 JW2518 yfhR 31,516 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021] GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P75978 YMFN_ECOLI Protein YmfN ymfN b1149 JW1135 ymfN 50,871 +P31827 YDDB_ECOLI Uncharacterized protein YddB (CDS103) yddB b1495 JW1490 yddB 89,283 +P31126 YDEE_ECOLI Uncharacterized MFS-type transporter YdeE ydeE ydeF b1534 JW1527 ydeF ydeE 42,659 dipeptide transmembrane transport [GO:0035442]; protein transport [GO:0015031]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; dipeptide transmembrane transporter activity [GO:0071916]; dipeptide transmembrane transport [GO:0035442]; protein transport [GO:0015031]; transmembrane transport [GO:0055085] dipeptide transmembrane transporter activity [GO:0071916] GO:0005886; GO:0015031; GO:0016021; GO:0035442; GO:0055085; GO:0071916 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0AD24 YEJL_ECOLI UPF0352 protein YejL yejL b2187 JW2175 yejL 8,288 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P33916 YEJF_ECOLI Uncharacterized ABC transporter ATP-binding protein YejF yejF b2180 JW2168 yejF 58,726 microcin transport [GO:0042884]; oligopeptide transmembrane transport [GO:0035672]; transmembrane transport [GO:0055085] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; oligopeptide transmembrane transporter activity [GO:0035673]; transmembrane transporter activity [GO:0022857]; microcin transport [GO:0042884]; oligopeptide transmembrane transport [GO:0035672]; transmembrane transport [GO:0055085] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; oligopeptide transmembrane transporter activity [GO:0035673]; transmembrane transporter activity [GO:0022857] GO:0005524; GO:0005886; GO:0022857; GO:0035672; GO:0035673; GO:0042626; GO:0042884; GO:0055085 +P0A7N4 RL32_ECOLI 50S ribosomal protein L32 (Large ribosomal subunit protein bL32) rpmF b1089 JW1075 rpmF 6,446 response to radiation [GO:0009314]; response to reactive oxygen species [GO:0000302]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; structural constituent of ribosome [GO:0003735]; response to radiation [GO:0009314]; response to reactive oxygen species [GO:0000302]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] structural constituent of ribosome [GO:0003735] GO:0000027; GO:0000302; GO:0003735; GO:0005829; GO:0006412; GO:0009314; GO:0022625 +P0AFW4 RNK_ECOLI Regulator of nucleoside diphosphate kinase rnk b0610 JW0602 rnk 14,927 DNA-templated transcription, elongation [GO:0006354]; regulation of DNA-templated transcription, elongation [GO:0032784] DNA binding [GO:0003677]; RNA polymerase binding [GO:0070063]; DNA-templated transcription, elongation [GO:0006354]; regulation of DNA-templated transcription, elongation [GO:0032784] DNA binding [GO:0003677]; RNA polymerase binding [GO:0070063] GO:0003677; GO:0006354; GO:0032784; GO:0070063 +P0A800 RPOZ_ECOLI DNA-directed RNA polymerase subunit omega (RNAP omega subunit) (EC 2.7.7.6) (RNA polymerase omega subunit) (Transcriptase subunit omega) rpoZ b3649 JW3624 rpoZ 10,237 protein-containing complex assembly [GO:0065003]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829]; RNA polymerase complex [GO:0030880] cytosol [GO:0005829]; RNA polymerase complex [GO:0030880]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein-containing complex assembly [GO:0065003]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899] GO:0003677; GO:0003899; GO:0005829; GO:0006351; GO:0030880; GO:0065003 +P31825 TRMN6_ECOLI tRNA1(Val) (adenine(37)-N6)-methyltransferase (EC 2.1.1.223) (tRNA m6A37 methyltransferase) yfiC b2575 JW2559 yfiC 27,270 tRNA methylation [GO:0030488] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; nucleic acid binding [GO:0003676]; tRNA (adenine-N6-)-methyltransferase activity [GO:0016430]; tRNA methylation [GO:0030488] nucleic acid binding [GO:0003676]; tRNA (adenine-N6-)-methyltransferase activity [GO:0016430] GO:0003676; GO:0005737; GO:0016430; GO:0030488 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P76055 TTCA_ECOLI tRNA-cytidine(32) 2-sulfurtransferase (EC 2.8.1.-) (Two-thiocytidine biosynthesis protein A) (tRNA 2-thiocytidine biosynthesis protein TtcA) ttcA ydaO b1344 JW1338 ydaO ttcA 35,561 tRNA modification [GO:0006400]; tRNA thio-modification [GO:0034227] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; sulfurtransferase activity [GO:0016783]; tRNA binding [GO:0000049]; tRNA modification [GO:0006400]; tRNA thio-modification [GO:0034227] 4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; sulfurtransferase activity [GO:0016783]; tRNA binding [GO:0000049] GO:0000049; GO:0000287; GO:0005524; GO:0005829; GO:0006400; GO:0016783; GO:0034227; GO:0051539 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01850, ECO:0000305}. +P37440 UCPA_ECOLI Oxidoreductase UcpA (EC 1.-.-.-) ucpA yfeF b2426 JW5394 yfeF ucpA 27,850 diacetyl reductase ((S)-acetoin forming) activity [GO:0052588] diacetyl reductase ((S)-acetoin forming) activity [GO:0052588] GO:0052588 +P37749 WBBI_ECOLI Beta-1,6-galactofuranosyltransferase WbbI (EC 2.4.1.-) (D-Galf:alpha-D-Glc beta-1,6-galactofuranosyltransferase) (GalF transferase) wbbI yefG b2034 JW2019 yefG wbbI 37,757 lipopolysaccharide biosynthetic process [GO:0009103] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; lipopolysaccharide-1,6-galactosyltransferase activity [GO:0008921]; lipopolysaccharide biosynthetic process [GO:0009103] lipopolysaccharide-1,6-galactosyltransferase activity [GO:0008921] GO:0005737; GO:0008921; GO:0009103 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AAX8 YBIS_ECOLI Probable L,D-transpeptidase YbiS (EC 2.-.-.-) ybiS b0819 JW0803 ybiS 33,325 cell wall organization [GO:0071555]; peptidoglycan-protein cross-linking [GO:0018104]; regulation of cell shape [GO:0008360] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; peptidoglycan L,D-transpeptidase activity [GO:0071972]; transferase activity, transferring glycosyl groups [GO:0016757]; cell wall organization [GO:0071555]; peptidoglycan-protein cross-linking [GO:0018104]; regulation of cell shape [GO:0008360] peptidoglycan L,D-transpeptidase activity [GO:0071972]; transferase activity, transferring glycosyl groups [GO:0016757] GO:0008360; GO:0016757; GO:0018104; GO:0030288; GO:0071555; GO:0071972 SUBCELLULAR LOCATION: Periplasm. +P30866 YAFE_ECOLI Uncharacterized protein YafE yafE b0210 JW0200 yafE 22,991 methyltransferase activity [GO:0008168] methyltransferase activity [GO:0008168] GO:0008168 +P0AAT9 YBEL_ECOLI Uncharacterized protein YbeL ybeL b0643 JW0638 ybeL 18,797 +P39220 YABP_ECOLI Protein YabP yabP b4659 JW0055 b0056 yabP 24,791 +P77234 YBEQ_ECOLI Sel1-repeat-containing protein YbeQ ybeQ b0644 JW5091 ybeQ 37,031 response to oxidative stress [GO:0006979] enzyme activator activity [GO:0008047]; response to oxidative stress [GO:0006979] enzyme activator activity [GO:0008047] GO:0006979; GO:0008047 +P77294 YDER_ECOLI Uncharacterized fimbrial-like protein YdeR ydeR b1503 JW1497 ydeR 18,144 cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. +P0AA73 YHBE_ECOLI Uncharacterized inner membrane transporter YhbE yhbE b3184 JW3151 yhbE 34,963 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P39831 YDFG_ECOLI NADP-dependent 3-hydroxy acid dehydrogenase YdfG (L-allo-threonine dehydrogenase) (EC 1.1.1.381) (Malonic semialdehyde reductase) (EC 1.1.1.298) ydfG b1539 JW1532 ydfG 27,249 fatty acid elongation [GO:0030497]; protein homotetramerization [GO:0051289]; uracil catabolic process [GO:0006212] cytosol [GO:0005829] cytosol [GO:0005829]; 3-hydroxyisobutyrate dehydrogenase activity [GO:0008442]; 3-hydroxypropionate dehydrogenase (NADP+) activity [GO:0035527]; identical protein binding [GO:0042802]; serine 3-dehydrogenase activity [GO:0031132]; fatty acid elongation [GO:0030497]; protein homotetramerization [GO:0051289]; uracil catabolic process [GO:0006212] 3-hydroxyisobutyrate dehydrogenase activity [GO:0008442]; 3-hydroxypropionate dehydrogenase (NADP+) activity [GO:0035527]; identical protein binding [GO:0042802]; serine 3-dehydrogenase activity [GO:0031132] GO:0005829; GO:0006212; GO:0008442; GO:0030497; GO:0031132; GO:0035527; GO:0042802; GO:0051289 +P29009 YDFB_ECOLI Uncharacterized protein YdfB ydfB b1572 JW1564 ydfB 4,688 cytoplasm [GO:0005737] cytoplasm [GO:0005737] GO:0005737 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21778229}. Note=Probably associated with the inner membrane. +P28722 YHCA_ECOLI Uncharacterized fimbrial chaperone YhcA yhcA b3215 JW3182 yhcA 25,339 cell wall organization [GO:0071555] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; cell wall organization [GO:0071555] GO:0030288; GO:0071555 SUBCELLULAR LOCATION: Periplasm {ECO:0000250}. +Q7DFU6 YGHX_ECOLI Putative hydrolase fragment YghX yghX yghY b4658 JW5926/JW5496 b2999 b3000 yghY yghX 12,628 hydrolase activity [GO:0016787] hydrolase activity [GO:0016787] GO:0016787 +P76630 YGAZ_ECOLI Inner membrane protein YgaZ ygaZ b2682 JW2657 ygaZ 26,108 L-valine transmembrane transport [GO:1903785] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; L-valine transmembrane transport [GO:1903785] GO:0005887; GO:1903785 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P25747 YEIB_ECOLI Uncharacterized protein YeiB yeiB b2152 JW2139 yeiB 43,394 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P08370 YGDB_ECOLI Uncharacterized protein YgdB ygdB b2824 JW5450 ygdB 14,973 +P76235 YEAH_ECOLI UPF0229 protein YeaH yeaH b1784 JW1773 yeaH 49,392 +Q46904 YGCN_ECOLI Probable electron transfer flavoprotein-quinone oxidoreductase YgcN (EC 1.5.5.-) ygcN b2766 JW2736 ygcN 46,393 oxidoreductase activity [GO:0016491] oxidoreductase activity [GO:0016491] GO:0016491 +P37674 YIAM_ECOLI 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM yiaM b3577 JW3549 yiaM 17,516 C4-dicarboxylate transport [GO:0015740]; carbohydrate transmembrane transport [GO:0034219] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; carbohydrate transmembrane transporter activity [GO:0015144]; transmembrane transporter activity [GO:0022857]; C4-dicarboxylate transport [GO:0015740]; carbohydrate transmembrane transport [GO:0034219] carbohydrate transmembrane transporter activity [GO:0015144]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0015144; GO:0015740; GO:0016021; GO:0022857; GO:0034219 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P67143 YHGN_ECOLI UPF0056 inner membrane protein YhgN yhgN b3434 JW3397 yhgN 21,490 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] GO:0005886; GO:0005887 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P39367 YJHP_ECOLI Uncharacterized protein YjhP yjhP b4306 JW4268 yjhP 27,354 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021] GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P0A8E1 YCFP_ECOLI UPF0227 protein YcfP ycfP b1108 JW5158 ycfP 21,226 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P64562 YQFE_ECOLI Putative protein YqfE yqfE b2915 JW2882 yqfE 8,372 +C1P614 YQFG_ECOLI Uncharacterized protein YqfG yqfG b4684 JW5470.1 yqfG 4,791 +O32583 THIS_ECOLI Sulfur carrier protein ThiS (Thiamine biosynthesis protein ThiS) thiS thiG1 b4407 JW3955 thiG1 thiS 7,311 thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] nucleotide binding [GO:0000166]; thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] nucleotide binding [GO:0000166] GO:0000166; GO:0009228; GO:0009229 +P11664 YGGC_ECOLI Uncharacterized protein YggC yggC b2928 JW2895 yggC 27,132 cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; kinase activity [GO:0016301] ATP binding [GO:0005524]; kinase activity [GO:0016301] GO:0005524; GO:0005737; GO:0016301 +P31448 YIDK_ECOLI Uncharacterized symporter YidK yidK b3679 JW3655 yidK 62,085 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; glucose:sodium symporter activity [GO:0005412] glucose:sodium symporter activity [GO:0005412] GO:0005412; GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76187 YDHF_ECOLI Oxidoreductase YdhF (EC 1.-.-.-) ydhF b1647 JW1639 ydhF 33,676 cytosol [GO:0005829] cytosol [GO:0005829]; D-threo-aldose 1-dehydrogenase activity [GO:0047834] D-threo-aldose 1-dehydrogenase activity [GO:0047834] GO:0005829; GO:0047834 +P28638 YHDJ_ECOLI DNA adenine methyltransferase YhdJ (EC 2.1.1.72) yhdJ b3262 JW5543 yhdJ 33,397 cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; methyltransferase activity [GO:0008168]; N-methyltransferase activity [GO:0008170]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007] DNA binding [GO:0003677]; methyltransferase activity [GO:0008168]; N-methyltransferase activity [GO:0008170]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007] GO:0003677; GO:0005737; GO:0008168; GO:0008170; GO:0009007 +P76197 YDIM_ECOLI Inner membrane transport protein YdiM ydiM b1690 JW1680 ydiM 44,608 integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016020; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77129 YLBE_ECOLI Uncharacterized protein YlbE ylbE b4572 b0519 ylbE 44,979 +P76486 YFBP_ECOLI Uncharacterized protein YfbP yfbP b2275 JW2270 yfbP 32,136 +P45766 YHDW_ECOLI Putative amino-acid ABC transporter-binding protein YhdW yhdW b3268 JW3236 yhdW 37,021 amino acid transport [GO:0006865] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; amino acid transport [GO:0006865] GO:0006865; GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P39834 YGIL_ECOLI Uncharacterized fimbrial-like protein YgiL ygiL b3043 JW3011 ygiL 19,494 cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. +P33360 YEHX_ECOLI Glycine betaine uptake system ATP-binding protein YehX (EC 7.4.2.-) yehX b2129 JW2117 yehX 34,425 amino acid transport [GO:0006865]; glycine betaine transport [GO:0031460] ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; amino acid transport [GO:0006865]; glycine betaine transport [GO:0031460] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0006865; GO:0031460; GO:0042626 +P45736 YCJD_ECOLI Uncharacterized protein YcjD ycjD b1289 JW1282 ycjD 13,989 +P52141 YFJZ_ECOLI Antitoxin YfjZ yfjZ b2645 JW2626 yfjZ 11,737 positive regulation of cytoskeleton organization [GO:0051495] positive regulation of cytoskeleton organization [GO:0051495] GO:0051495 +P76044 YCJR_ECOLI 3-dehydro-D-guloside 4-epimerase (EC 5.1.3.-) (3-keto-D-guloside 4-epimerase) ycjR b1314 JW5202 ycjR 29,832 carbohydrate metabolic process [GO:0005975] cytosol [GO:0005829] cytosol [GO:0005829]; manganese ion binding [GO:0030145]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]; carbohydrate metabolic process [GO:0005975] manganese ion binding [GO:0030145]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857] GO:0005829; GO:0005975; GO:0016857; GO:0030145 +P0ADK4 YIAW_ECOLI Inner membrane protein YiaW yiaW b3587 JW3559 yiaW 12,409 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P75677 YKFF_ECOLI UPF0401 protein YkfF ykfF b0249 JW5023 ykfF 9,014 +Q47685 YKFG_ECOLI UPF0758 protein YkfG ykfG b0247 JW0236 ykfG 18,099 cellular response to DNA damage stimulus [GO:0006974] metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; cellular response to DNA damage stimulus [GO:0006974] metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] GO:0006974; GO:0008237; GO:0046872 +P64515 YECN_ECOLI Inner membrane protein YecN yecN b1869 JW5308 yecN 15,226 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein. +P76349 YEEL_ECOLI Putative uncharacterized protein YeeL yeeL b4497 b1979/b1980 yeeL 26,725 lipopolysaccharide core region biosynthetic process [GO:0009244] cytosol [GO:0005829] cytosol [GO:0005829]; ADP-heptose-lipopolysaccharide heptosyltransferase activity [GO:0008713]; lipopolysaccharide core region biosynthetic process [GO:0009244] ADP-heptose-lipopolysaccharide heptosyltransferase activity [GO:0008713] GO:0005829; GO:0008713; GO:0009244 +P39381 YJIJ_ECOLI Uncharacterized protein YjiJ yjiJ b4332 JW4295 yjiJ 41,361 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0A8H6 YIHI_ECOLI Der GTPase-activating protein YihI (GAP) yihI b3866 JW3837 yihI 19,059 negative regulation of ribosome biogenesis [GO:0090071]; positive regulation of GTPase activity [GO:0043547]; ribosome biogenesis [GO:0042254] cytosol [GO:0005829] cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; negative regulation of ribosome biogenesis [GO:0090071]; positive regulation of GTPase activity [GO:0043547]; ribosome biogenesis [GO:0042254] GTPase activator activity [GO:0005096] GO:0005096; GO:0005829; GO:0042254; GO:0043547; GO:0090071 +P32137 YIHP_ECOLI Putative 2,3-dihydroxypropane-1-sulfonate exporter yihP b3877 JW3848 yihP 50,982 carbohydrate transport [GO:0008643]; organic substance transport [GO:0071702]; sodium ion transport [GO:0006814] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; symporter activity [GO:0015293]; carbohydrate transport [GO:0008643]; organic substance transport [GO:0071702]; sodium ion transport [GO:0006814] symporter activity [GO:0015293] GO:0005886; GO:0005887; GO:0006814; GO:0008643; GO:0015293; GO:0071702 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P39295 YJFM_ECOLI Uncharacterized protein YjfM yjfM b4185 JW4143 yjfM 23,352 +P37614 YHHL_ECOLI Uncharacterized protein YhhL yhhL b3466 JW5683 yhhL 10,252 +P28911 YHHH_ECOLI Uncharacterized protein YhhH (ORF-B2) yhhH b3483 JW3449 yhhH 14,531 +P75954 YCFS_ECOLI Probable L,D-transpeptidase YcfS (EC 2.-.-.-) ycfS b1113 JW5820 ycfS 34,636 cell wall organization [GO:0071555]; peptidoglycan-protein cross-linking [GO:0018104]; regulation of cell shape [GO:0008360] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; peptidoglycan L,D-transpeptidase activity [GO:0071972]; transferase activity, transferring glycosyl groups [GO:0016757]; cell wall organization [GO:0071555]; peptidoglycan-protein cross-linking [GO:0018104]; regulation of cell shape [GO:0008360] peptidoglycan L,D-transpeptidase activity [GO:0071972]; transferase activity, transferring glycosyl groups [GO:0016757] GO:0008360; GO:0016757; GO:0018104; GO:0042597; GO:0071555; GO:0071972 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P14375 ZRAR_ECOLI Transcriptional regulatory protein ZraR zraR hydG b4004 JW3968 hydG zraR 48,395 phosphorelay signal transduction system [GO:0000160]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; transcription, DNA-templated [GO:0006351] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; phosphorelay response regulator activity [GO:0000156]; sequence-specific DNA binding [GO:0043565]; transcription factor binding [GO:0008134]; phosphorelay signal transduction system [GO:0000160]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; transcription, DNA-templated [GO:0006351] ATP binding [GO:0005524]; DNA binding [GO:0003677]; phosphorelay response regulator activity [GO:0000156]; sequence-specific DNA binding [GO:0043565]; transcription factor binding [GO:0008134] GO:0000156; GO:0000160; GO:0003677; GO:0005524; GO:0005737; GO:0006351; GO:0008134; GO:0043565; GO:2000144 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P16686 PHNH_ECOLI Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH (RPnTP synthase subunit PhnH) (EC 2.7.8.37) phnH b4100 JW4061 phnH 21,027 organic phosphonate catabolic process [GO:0019700] alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex [GO:0061694]; carbon phosphorus lyase complex [GO:1904176] alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex [GO:0061694]; carbon phosphorus lyase complex [GO:1904176]; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity [GO:0061693]; identical protein binding [GO:0042802]; organic phosphonate catabolic process [GO:0019700] alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity [GO:0061693]; identical protein binding [GO:0042802] GO:0019700; GO:0042802; GO:0061693; GO:0061694; GO:1904176 +P0AFK0 PMBA_ECOLI Metalloprotease PmbA (EC 3.4.-.-) (Protein TldE) pmbA tldE b4235 JW4194 tldE pmbA 48,370 proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; metallopeptidase activity [GO:0008237]; proteolysis [GO:0006508] metallopeptidase activity [GO:0008237] GO:0005737; GO:0005829; GO:0006508; GO:0008237 SUBCELLULAR LOCATION: Cytoplasm. +P0ABF8 PGSA_ECOLI CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) (Phosphatidylglycerophosphate synthase) (PGP synthase) pgsA b1912 JW1897 pgsA 20,701 glycerophospholipid biosynthetic process [GO:0046474]; phosphatidylglycerol biosynthetic process [GO:0006655] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [GO:0008444]; glycerophospholipid biosynthetic process [GO:0046474]; phosphatidylglycerol biosynthetic process [GO:0006655] CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [GO:0008444] GO:0005886; GO:0006655; GO:0008444; GO:0016021; GO:0046474 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P31135 POTH_ECOLI Putrescine transport system permease protein PotH potH b0856 JW0840 potH 35,490 putrescine transport [GO:0015847]; transmembrane transport [GO:0055085] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; putrescine transport [GO:0015847]; transmembrane transport [GO:0055085] GO:0005886; GO:0005887; GO:0015847; GO:0043190; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P0AGE4 SSTT_ECOLI Serine/threonine transporter SstT (Na(+)/serine-threonine symporter) sstT ygjU b3089 JW3060 ygjU sstT 43,478 amino acid transport [GO:0006865]; serine transport [GO:0032329]; threonine transport [GO:0015826] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; neutral amino acid transmembrane transporter activity [GO:0015175]; neutral amino acid:sodium symporter activity [GO:0005295]; transmembrane transporter activity [GO:0022857]; amino acid transport [GO:0006865]; serine transport [GO:0032329]; threonine transport [GO:0015826] neutral amino acid:sodium symporter activity [GO:0005295]; neutral amino acid transmembrane transporter activity [GO:0015175]; transmembrane transporter activity [GO:0022857] GO:0005295; GO:0005886; GO:0006865; GO:0015175; GO:0015826; GO:0016020; GO:0016021; GO:0022857; GO:0032329 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AG24 SPOT_ECOLI Bifunctional (p)ppGpp synthase/hydrolase SpoT [Includes: GTP pyrophosphokinase (EC 2.7.6.5) ((p)ppGpp synthase) (ATP:GTP 3'-pyrophosphotransferase) (Stringent response-like protein) (ppGpp synthase II); Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase)] spoT b3650 JW3625 spoT 79,342 guanosine tetraphosphate biosynthetic process [GO:0015970]; guanosine tetraphosphate metabolic process [GO:0015969]; nucleobase-containing small molecule interconversion [GO:0015949]; response to starvation [GO:0042594] cytosol [GO:0005829] cytosol [GO:0005829]; GTP diphosphokinase activity [GO:0008728]; guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity [GO:0008893]; kinase activity [GO:0016301]; guanosine tetraphosphate biosynthetic process [GO:0015970]; guanosine tetraphosphate metabolic process [GO:0015969]; nucleobase-containing small molecule interconversion [GO:0015949]; response to starvation [GO:0042594] GTP diphosphokinase activity [GO:0008728]; guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity [GO:0008893]; kinase activity [GO:0016301] GO:0005829; GO:0008728; GO:0008893; GO:0015949; GO:0015969; GO:0015970; GO:0016301; GO:0042594 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17616600}. Note=Is associated with pre-50S ribosomal subunits in a salt-dependent manner. +P12758 UDP_ECOLI Uridine phosphorylase (UPase) (UrdPase) (EC 2.4.2.3) udp b3831 JW3808 udp 27,159 cellular response to DNA damage stimulus [GO:0006974]; nucleotide catabolic process [GO:0009166]; UMP salvage [GO:0044206]; uridine catabolic process [GO:0006218] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; potassium ion binding [GO:0030955]; uridine phosphorylase activity [GO:0004850]; cellular response to DNA damage stimulus [GO:0006974]; nucleotide catabolic process [GO:0009166]; UMP salvage [GO:0044206]; uridine catabolic process [GO:0006218] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; potassium ion binding [GO:0030955]; uridine phosphorylase activity [GO:0004850] GO:0004850; GO:0005524; GO:0005829; GO:0006218; GO:0006974; GO:0009166; GO:0030955; GO:0032991; GO:0042802; GO:0044206 SUBCELLULAR LOCATION: Cytoplasm. +P69428 TATA_ECOLI Sec-independent protein translocase protein TatA tatA mttA1 yigT b3836 JW3813 mttA1 yigT tatA 9,664 intracellular protein transmembrane transport [GO:0065002]; protein transport by the Tat complex [GO:0043953] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; TAT protein transport complex [GO:0033281] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; TAT protein transport complex [GO:0033281]; identical protein binding [GO:0042802]; protein transmembrane transporter activity [GO:0008320]; proton motive force dependent protein transmembrane transporter activity [GO:0009977]; intracellular protein transmembrane transport [GO:0065002]; protein transport by the Tat complex [GO:0043953] identical protein binding [GO:0042802]; protein transmembrane transporter activity [GO:0008320]; proton motive force dependent protein transmembrane transporter activity [GO:0009977] GO:0005829; GO:0005887; GO:0008320; GO:0009977; GO:0016021; GO:0033281; GO:0042802; GO:0043953; GO:0065002 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00236, ECO:0000269|PubMed:11591389, ECO:0000269|PubMed:15225613, ECO:0000269|PubMed:20169075}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00236, ECO:0000269|PubMed:11591389, ECO:0000269|PubMed:15225613, ECO:0000269|PubMed:20169075}; Cytoplasmic side {ECO:0000269|PubMed:11591389, ECO:0000269|PubMed:15225613, ECO:0000269|PubMed:20169075}. Note=Abundant all over the membrane, but is more concentrated at the cell poles. +P71244 WCAM_ECOLI Colanic acid biosynthesis protein WcaM wcaM yefK b2043 JW2028 yefK wcaM 51,316 lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] GO:0009103; GO:0045228 +P0AFQ2 YBHS_ECOLI Probable multidrug ABC transporter permease YbhS ybhS b0793 JW0777 ybhS 42,060 transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; efflux transmembrane transporter activity [GO:0015562]; transmembrane transporter activity [GO:0022857]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] efflux transmembrane transporter activity [GO:0015562]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0015562; GO:0022857; GO:0043190; GO:0055085; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P46890 YBAE_ECOLI Uncharacterized protein YbaE ybaE b0445 JW0435 ybaE 64,992 peptide transport [GO:0015833] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; peptide transmembrane transporter activity [GO:1904680]; peptide transport [GO:0015833] peptide transmembrane transporter activity [GO:1904680] GO:0015833; GO:0030288; GO:1904680 +P77376 YDGJ_ECOLI Uncharacterized oxidoreductase YdgJ (EC 1.-.-.-) ydgJ b1624 JW5265 ydgJ 38,257 nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491] nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491] GO:0000166; GO:0016491 +P0AD37 YFEC_ECOLI Uncharacterized protein YfeC yfeC b2398 JW2393 yfeC 12,720 +P77409 YDHU_ECOLI Putative cytochrome YdhU (Protein PhsC homolog) ydhU b1670 JW1660 ydhU 29,583 respiratory electron transport chain [GO:0022904] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; respiratory electron transport chain [GO:0022904] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872] GO:0005886; GO:0005887; GO:0009055; GO:0020037; GO:0022904; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P0AD44 YFHG_ECOLI Uncharacterized protein YfhG yfhG b2555 JW2539 yfhG 27,348 regulation of phosphorelay signal transduction system [GO:0070297]; regulation of protein phosphorylation [GO:0001932] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; regulation of phosphorelay signal transduction system [GO:0070297]; regulation of protein phosphorylation [GO:0001932] GO:0001932; GO:0030288; GO:0070297 +P0ABT8 YIJE_ECOLI Probable cystine transporter YijE yijE b3943 JW5557 yijE 32,866 sulfur amino acid transport [GO:0000101] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; sulfur amino acid transmembrane transporter activity [GO:0000099]; sulfur amino acid transport [GO:0000101] sulfur amino acid transmembrane transporter activity [GO:0000099] GO:0000099; GO:0000101; GO:0005886; GO:0005887; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +Q46832 YGHD_ECOLI Putative type II secretion system M-type protein YghD (Putative T2SS M-type protein YghD) (Putative extracytoplasmic function protein C) (Putative general secretion pathway M-type protein YghD) yghD ecfC b2968 JW2935 ecfC yghD 20,395 protein secretion by the type II secretion system [GO:0015628] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627]; protein secretion by the type II secretion system [GO:0015628] GO:0005886; GO:0015627; GO:0015628; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P0ADV5 YHBW_ECOLI Luciferase-like monooxygenase yhbW b3160 JW3129 yhbW 37,129 cytosol [GO:0005829] cytosol [GO:0005829]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705] oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705] GO:0005829; GO:0016705 +P76393 YEGI_ECOLI Protein kinase YegI (EC 2.7.-.-) yegI b2070 JW2055 yegI 71,639 ATP binding [GO:0005524]; protein kinase activity [GO:0004672] ATP binding [GO:0005524]; protein kinase activity [GO:0004672] GO:0004672; GO:0005524 +P76122 YDDJ_ECOLI Putative protein YddJ yddJ b1470 JW1466 yddJ 12,872 +P55140 YGCG_ECOLI UPF0603 protein YgcG ygcG b2778 JW5445 ygcG 32,206 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P31991 YDCD_ECOLI Uncharacterized protein YdcD (ORF-E2) ydcD b1457 JW1452 ydcD 18,907 +P64455 YDCY_ECOLI Uncharacterized protein YdcY ydcY b1446 JW1441 ydcY 8,800 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P77519 YDDL_ECOLI Protein YddL yddL b1472 JW1468 yddL 10,736 ion transmembrane transport [GO:0034220] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; porin activity [GO:0015288]; ion transmembrane transport [GO:0034220] porin activity [GO:0015288] GO:0009279; GO:0015288; GO:0034220 +P33913 YEJA_ECOLI Uncharacterized protein YejA yejA b2177 JW2165 yejA 69,669 microcin transport [GO:0042884]; oligopeptide transport [GO:0006857]; peptide transport [GO:0015833] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288]; peptide transmembrane transporter activity [GO:1904680]; microcin transport [GO:0042884]; oligopeptide transport [GO:0006857]; peptide transport [GO:0015833] peptide transmembrane transporter activity [GO:1904680] GO:0006857; GO:0015833; GO:0030288; GO:0042884; GO:0043190; GO:1904680 +P77536 YKGF_ECOLI Uncharacterized electron transport protein YkgF ykgF b0307 JW0300 ykgF 53,052 lactate oxidation [GO:0019516] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; lactate oxidation [GO:0019516] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0019516; GO:0046872; GO:0051539 +P0ACY6 YEAL_ECOLI UPF0756 membrane protein YeaL yeaL b1789 JW1778 yeaL 15,256 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] GO:0005886; GO:0005887 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01874}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01874}. +P0AD07 YECF_ECOLI Uncharacterized protein YecF yecF b1915 JW1900 yecF 8,239 +P76272 YEBT_ECOLI Intermembrane transport protein YebT yebT b1834 JW1823 yebT 94,970 intermembrane lipid transfer [GO:0120009] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; identical protein binding [GO:0042802]; intermembrane lipid transfer [GO:0120009] identical protein binding [GO:0042802] GO:0005887; GO:0030288; GO:0042802; GO:0120009 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:27795327}; Single-pass membrane protein {ECO:0000255}; Periplasmic side {ECO:0000269|PubMed:27795327}. +P37052 YCHJ_ECOLI UPF0225 protein YchJ ychJ b1233 JW1221 ychJ 16,990 +P0AF78 YJFJ_ECOLI Uncharacterized protein YjfJ yjfJ b4182 JW4140 yjfJ 25,334 identical protein binding [GO:0042802] identical protein binding [GO:0042802] GO:0042802 +P0AF36 ZAPB_ECOLI Cell division protein ZapB zapB yiiU b3928 JW3899 yiiU zapB 9,635 division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093] cell division site [GO:0032153]; cytosol [GO:0005829] cell division site [GO:0032153]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093] identical protein binding [GO:0042802] GO:0000917; GO:0005829; GO:0032153; GO:0042802; GO:0043093 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18394147}. Note=Localizes to the septum at mid-cell, in a FtsZ-like pattern. +P33941 YOJI_ECOLI ABC transporter ATP-binding/permease protein YojI yojI yojJ b2211 JW2199 yojJ yojI 61,553 microcin transport [GO:0042884]; response to antibiotic [GO:0046677] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of membrane [GO:0016021] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of membrane [GO:0016021]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; peptide transmembrane transporter activity [GO:1904680]; microcin transport [GO:0042884]; response to antibiotic [GO:0046677] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; peptide transmembrane transporter activity [GO:1904680] GO:0005524; GO:0016021; GO:0042626; GO:0042884; GO:0043190; GO:0046677; GO:1904680 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P0AD19 YOHK_ECOLI Inner membrane protein YohK yohK b2142 JW2130 yohK 24,470 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P65294 YGDR_ECOLI Uncharacterized lipoprotein YgdR ygdR b2833 JW2801 ygdR 7,877 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P0ACW4 YDCA_ECOLI Uncharacterized protein YdcA ydcA b1419 JW1416 ydcA 5,860 +P0A8I5 TRMB_ECOLI tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase) trmB trmI yggH b2960 JW2927 trmI yggH trmB 27,307 RNA (guanine-N7)-methylation [GO:0036265]; tRNA methylation [GO:0030488] tRNA methyltransferase complex [GO:0043527] tRNA methyltransferase complex [GO:0043527]; tRNA (guanine-N7-)-methyltransferase activity [GO:0008176]; RNA (guanine-N7)-methylation [GO:0036265]; tRNA methylation [GO:0030488] tRNA (guanine-N7-)-methyltransferase activity [GO:0008176] GO:0008176; GO:0030488; GO:0036265; GO:0043527 +P60340 TRUB_ECOLI tRNA pseudouridine synthase B (EC 5.4.99.25) (Protein P35) (tRNA pseudouridine(55) synthase) (Psi55 synthase) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase) truB yhbA b3166 JW3135 yhbA truB 35,087 mRNA pseudouridine synthesis [GO:1990481]; tRNA folding [GO:0061818]; tRNA modification [GO:0006400]; tRNA pseudouridine synthesis [GO:0031119] cytosol [GO:0005829] cytosol [GO:0005829]; pseudouridine synthase activity [GO:0009982]; tRNA binding [GO:0000049]; tRNA pseudouridine synthase activity [GO:0106029]; mRNA pseudouridine synthesis [GO:1990481]; tRNA folding [GO:0061818]; tRNA modification [GO:0006400]; tRNA pseudouridine synthesis [GO:0031119] pseudouridine synthase activity [GO:0009982]; tRNA binding [GO:0000049]; tRNA pseudouridine synthase activity [GO:0106029] GO:0000049; GO:0005829; GO:0006400; GO:0009982; GO:0031119; GO:0061818; GO:0106029; GO:1990481 +Q46948 YAJL_ECOLI Protein/nucleic acid deglycase 3 (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Chaperone protein YajL) (Maillard deglycase) yajL thiJ b0424 JW5057 thiJ yajL 20,777 cellular response to oxidative stress [GO:0034599]; DNA repair [GO:0006281]; guanine deglycation, glyoxal removal [GO:0106046]; protein deglycation [GO:0036525]; protein deglycation, glyoxal removal [GO:0036529]; protein refolding [GO:0042026]; protein repair [GO:0030091]; response to heat [GO:0009408]; ribosome biogenesis [GO:0042254] cytosol [GO:0005829] cytosol [GO:0005829]; hydrolase activity [GO:0016787]; protein deglycase activity [GO:0036524]; cellular response to oxidative stress [GO:0034599]; DNA repair [GO:0006281]; guanine deglycation, glyoxal removal [GO:0106046]; protein deglycation [GO:0036525]; protein deglycation, glyoxal removal [GO:0036529]; protein refolding [GO:0042026]; protein repair [GO:0030091]; response to heat [GO:0009408]; ribosome biogenesis [GO:0042254] hydrolase activity [GO:0016787]; protein deglycase activity [GO:0036524] GO:0005829; GO:0006281; GO:0009408; GO:0016787; GO:0030091; GO:0034599; GO:0036524; GO:0036525; GO:0036529; GO:0042026; GO:0042254; GO:0106046 +P77328 YBBY_ECOLI Putative purine permease YbbY ybbY glxB4 b0513 JW0501 glxB4 ybbY 47,239 xanthine transport [GO:0042906] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; xanthine transmembrane transporter activity [GO:0042907]; xanthine transport [GO:0042906] xanthine transmembrane transporter activity [GO:0042907] GO:0005887; GO:0042906; GO:0042907 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77779 YBFO_ECOLI Putative uncharacterized protein YbfO ybfO b0703 JW0692 ybfO 55,232 +P77634 YBCM_ECOLI Uncharacterized HTH-type transcriptional regulator YbcM ybcM b0546 JW0534 ybcM 30,841 cellular response to DNA damage stimulus [GO:0006974]; response to antibiotic [GO:0046677] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; cellular response to DNA damage stimulus [GO:0006974]; response to antibiotic [GO:0046677] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006974; GO:0046677 +P68661 YBCO_ECOLI Putative nuclease YbcO (EC 3.1.-.-) ybcO b0549 JW0537 ybcO 10,348 metal ion binding [GO:0046872]; nuclease activity [GO:0004518] metal ion binding [GO:0046872]; nuclease activity [GO:0004518] GO:0004518; GO:0046872 +P76042 YCJN_ECOLI Putative ABC transporter periplasmic-binding protein YcjN ycjN b1310 JW1303 ycjN 46,808 periplasmic space [GO:0042597] periplasmic space [GO:0042597] GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P76065 YDAU_ECOLI Uncharacterized protein YdaU ydaU b1359 JW1354 ydaU 32,509 +P77615 YCJW_ECOLI Uncharacterized HTH-type transcriptional regulator YcjW ycjW b1320 JW1313 ycjW 36,134 cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006351; GO:0006355; GO:0006974 +P76034 YCIT_ECOLI Uncharacterized HTH-type transcriptional regulator YciT yciT b1284 JW1276 yciT 27,603 cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0005829; GO:0006355; GO:0006974 +P37683 YIAV_ECOLI Inner membrane protein YiaV yiaV b3586 JW3558 yiaV 41,771 transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transport [GO:0055085] GO:0005886; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77481 YCJV_ECOLI Putative uncharacterized ABC transporter ATP-binding protein YcjV ycjV ymjB b4524 JW1311/JW5203 b1318 ymjB ycjV 40,147 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052] ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0042626; GO:0055052 +Q46911 YGCU_ECOLI Uncharacterized FAD-linked oxidoreductase YgcU (EC 1.-.-.-) ygcU ygcT ygcV b4463 JW5442 ygcT ygcV ygcU 53,737 FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491] FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491] GO:0016491; GO:0071949 +P31475 YIEP_ECOLI Uncharacterized HTH-type transcriptional regulator YieP yieP b3755 JW5608 yieP 26,076 cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0005829 +P27848 YIGL_ECOLI Pyridoxal phosphate phosphatase YigL (EC 3.1.3.74) (PLP phosphatase) (Sugar phosphatase) (EC 3.1.3.23) yigL b3826 JW5854 yigL 29,708 cytosol [GO:0005829] cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; pyridoxal phosphatase activity [GO:0033883]; sugar-phosphatase activity [GO:0050308] magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; pyridoxal phosphatase activity [GO:0033883]; sugar-phosphatase activity [GO:0050308] GO:0000287; GO:0005829; GO:0016791; GO:0033883; GO:0046872; GO:0050308 +P75678 YKFA_ECOLI Uncharacterized protein YkfA ykfA b0253 JW0243 ykfA 31,892 tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTP binding [GO:0005525]; tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] GTP binding [GO:0005525] GO:0002098; GO:0005525; GO:0005737; GO:0005829; GO:0030488 +P0ACA1 YIBF_ECOLI Uncharacterized GST-like protein YibF yibF b3592 JW3565 yibF 22,545 glutathione metabolic process [GO:0006749]; L-phenylalanine catabolic process [GO:0006559] cytosol [GO:0005829] cytosol [GO:0005829]; glutathione transferase activity [GO:0004364]; maleylacetoacetate isomerase activity [GO:0016034]; glutathione metabolic process [GO:0006749]; L-phenylalanine catabolic process [GO:0006559] glutathione transferase activity [GO:0004364]; maleylacetoacetate isomerase activity [GO:0016034] GO:0004364; GO:0005829; GO:0006559; GO:0006749; GO:0016034 +P0AF34 YIIR_ECOLI Uncharacterized protein YiiR yiiR b3921 JW3892 yiiR 16,542 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 +P0AGH1 YHHJ_ECOLI Inner membrane transport permease YhhJ yhhJ b3485 JW5677 yhhJ 41,062 transmembrane transport [GO:0055085] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; transmembrane transport [GO:0055085] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0022857; GO:0043190; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P32681 YJAH_ECOLI Uncharacterized protein YjaH yjaH b4001 JW3965 yjaH 26,317 +P0ADD9 YJJY_ECOLI Uncharacterized protein YjjY yjjY b4402 JW4365 yjjY 4,886 +P75946 YCFL_ECOLI Uncharacterized protein YcfL ycfL b1104 JW1090 ycfL 13,981 cellular response to DNA damage stimulus [GO:0006974] cellular response to DNA damage stimulus [GO:0006974] GO:0006974 +P37640 YHJB_ECOLI Putative HTH-type transcriptional regulator YhjB yhjB b3520 JW3488 yhjB 22,604 regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677] GO:0003677; GO:0006355 +Q46855 YQHC_ECOLI Uncharacterized HTH-type transcriptional regulator YqhC yqhC b3010 JW5849 yqhC 35,957 positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216] GO:0000986; GO:0001216; GO:0006355; GO:0045893 +P42914 YRAI_ECOLI Probable fimbrial chaperone YraI yraI b3143 JW3112 yraI 25,677 cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] GO:0030288; GO:0043711; GO:0061077; GO:0071555 SUBCELLULAR LOCATION: Periplasm {ECO:0000250}. +P0DPP8 YSDD_ECOLI Protein YsdD ysdD b4757 ysdD 3,112 +O32528 YPDI_ECOLI Uncharacterized lipoprotein YpdI ypdI b2376 JW2373 ypdI 10,162 colanic acid biosynthetic process [GO:0009242] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; colanic acid biosynthetic process [GO:0009242] GO:0005886; GO:0009242 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +A5A615 YNCL_ECOLI Uncharacterized protein YncL yncL b4598 JW1439.1 yncL 3,538 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:19121005, ECO:0000305|PubMed:21778229}; Single-pass membrane protein {ECO:0000269|PubMed:19121005, ECO:0000269|PubMed:21778229}. +P0DPO5 YNCO_ECOLI Protein YncO yncO b4745 yncO 7,383 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. +P0DPO7 YNEP_ECOLI Protein YneP yneP b4747 yneP 4,711 +P0AGM9 XANP_ECOLI Xanthine permease XanP xanP yicE b3654 JW3629 yicE xanP 48,868 xanthine transport [GO:0042906] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; xanthine transmembrane transporter activity [GO:0042907]; xanthine transport [GO:0042906] xanthine transmembrane transporter activity [GO:0042907] GO:0005886; GO:0005887; GO:0042906; GO:0042907 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16096267}; Multi-pass membrane protein {ECO:0000269|PubMed:16096267}. +P67444 XANQ_ECOLI Xanthine permease XanQ xanQ ygfO b2882 JW2850 ygfO xanQ 49,108 xanthine transport [GO:0042906] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; xanthine transmembrane transporter activity [GO:0042907]; xanthine transport [GO:0042906] xanthine transmembrane transporter activity [GO:0042907] GO:0005886; GO:0005887; GO:0042906; GO:0042907 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16096267}; Multi-pass membrane protein {ECO:0000269|PubMed:16096267}. +P71239 WCAE_ECOLI Putative colanic acid biosynthesis glycosyl transferase WcaE wcaE b2055 JW2040 wcaE 27,894 colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] fucosyltransferase activity [GO:0008417]; transferase activity, transferring glycosyl groups [GO:0016757]; colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] fucosyltransferase activity [GO:0008417]; transferase activity, transferring glycosyl groups [GO:0016757] GO:0008417; GO:0009103; GO:0009242; GO:0016757; GO:0045228 +P75769 YBHM_ECOLI Uncharacterized protein YbhM ybhM b0787 JW0770 ybhM 26,123 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0AAA1 YAGU_ECOLI Inner membrane protein YagU yagU b0287 JW0281 yagU 22,967 response to acidic pH [GO:0010447] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; response to acidic pH [GO:0010447] GO:0005886; GO:0010447; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137}. +P75821 YBJS_ECOLI Uncharacterized protein YbjS ybjS b0868 JW5819 ybjS 38,086 catalytic activity [GO:0003824] catalytic activity [GO:0003824] GO:0003824 +P77393 YAHL_ECOLI Uncharacterized protein YahL yahL b0326 JW0318 yahL 31,793 +P75915 YCDY_ECOLI Chaperone protein YcdY ycdY b1035 JW1018 ycdY 20,724 bacterial-type flagellum-dependent swarming motility [GO:0071978]; cellular response to DNA damage stimulus [GO:0006974] cytosol [GO:0005829] cytosol [GO:0005829]; bacterial-type flagellum-dependent swarming motility [GO:0071978]; cellular response to DNA damage stimulus [GO:0006974] GO:0005829; GO:0006974; GO:0071978 +P0AAR3 YBAK_ECOLI Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK (EC 4.2.-.-) ybaK b0481 JW0470 ybaK 17,093 response to X-ray [GO:0010165]; translation [GO:0006412] cytosol [GO:0005829] cytosol [GO:0005829]; aminoacyl-tRNA editing activity [GO:0002161]; Cys-tRNA(Pro) hydrolase activity [GO:0043907]; lyase activity [GO:0016829]; response to X-ray [GO:0010165]; translation [GO:0006412] aminoacyl-tRNA editing activity [GO:0002161]; Cys-tRNA(Pro) hydrolase activity [GO:0043907]; lyase activity [GO:0016829] GO:0002161; GO:0005829; GO:0006412; GO:0010165; GO:0016829; GO:0043907 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P0DPM6 YACM_ECOLI Protein YacM yacM b4727 yacM 1,690 +P37017 YADL_ECOLI Uncharacterized fimbrial-like protein YadL yadL b0137 JW0133 yadL 21,047 cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. +P0AG84 YGHA_ECOLI Uncharacterized oxidoreductase YghA (EC 1.-.-.-) yghA b3003 JW2972 yghA 31,488 alcohol dehydrogenase (NADP+) activity [GO:0008106]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] alcohol dehydrogenase (NADP+) activity [GO:0008106]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] GO:0008106; GO:0016616 +P76516 YFDT_ECOLI Uncharacterized protein YfdT yfdT b2363 JW5887 yfdT 12,133 +P46474 YHDP_ECOLI Uncharacterized protein YhdP yhdP yhdQ yhdR b4472 JW5542 yhdQ yhdR yhdP 139,053 integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288] GO:0005887; GO:0030288 +P76543 YFFL_ECOLI Uncharacterized protein YffL yffL b2443 yffL 25,143 +P75972 YMFI_ECOLI Uncharacterized protein YmfI ymfI b1143 JW5168 ymfI 12,883 +P76066 YDAW_ECOLI Protein YdaW ydaW b1361 JW5211 ydaW 20,050 +P0AFR9 YDCV_ECOLI Inner membrane ABC transporter permease protein YdcV ydcV b1443 JW1438 ydcV 28,722 DNA import into cell involved in transformation [GO:0009290]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; DNA import into cell involved in transformation [GO:0009290]; transmembrane transport [GO:0055085] GO:0005886; GO:0009290; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P75968 YMFE_ECOLI Uncharacterized protein YmfE ymfE b1138 JW5166 ymfE 27,579 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P76049 YCJY_ECOLI Uncharacterized protein YcjY ycjY b1327 JW5804 ycjY 33,659 cell division [GO:0051301] cell division [GO:0051301] GO:0051301 +P31131 YDEJ_ECOLI Protein YdeJ ydeJ b1537 JW1530 ydeJ 18,321 +P76103 YDCO_ECOLI Inner membrane protein YdcO ydcO b1433 JW5229 ydcO 40,583 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; benzoate transmembrane transporter activity [GO:0042925] benzoate transmembrane transporter activity [GO:0042925] GO:0005886; GO:0016021; GO:0042925 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AFT8 YEIW_ECOLI UPF0153 protein YeiW yeiW b4502 JW5361 yeiW 8,954 +P0AGM2 YICG_ECOLI UPF0126 inner membrane protein YicG yicG b3646 JW3621 yicG 22,048 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0CD93 YMJD_ECOLI Protein YmjD ymjD b4673 JW5960.1 ymjD 2,465 +P56259 YIFN_ECOLI Putative uncharacterized protein YifN yifN b3777 JW3749 b3776 yifN 16,873 DNA binding [GO:0003677] DNA binding [GO:0003677] GO:0003677 +P39293 YJFK_ECOLI Uncharacterized protein YjfK yjfK b4183 JW4141 yjfK 25,009 +P39277 YJEH_ECOLI L-methionine/branched-chain amino acid exporter YjeH yjeH b4141 JW4101 yjeH 44,778 cellular response to amino acid stimulus [GO:0071230]; isoleucine transmembrane transport [GO:1903714]; leucine transport [GO:0015820]; L-valine transmembrane transport [GO:1903785]; methionine transport [GO:0015821] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; L-methionine secondary active transmembrane transporter activity [GO:0000102]; neutral L-amino acid secondary active transmembrane transporter activity [GO:0005294]; cellular response to amino acid stimulus [GO:0071230]; isoleucine transmembrane transport [GO:1903714]; L-valine transmembrane transport [GO:1903785]; leucine transport [GO:0015820]; methionine transport [GO:0015821] L-methionine secondary active transmembrane transporter activity [GO:0000102]; neutral L-amino acid secondary active transmembrane transporter activity [GO:0005294] GO:0000102; GO:0005294; GO:0005886; GO:0005887; GO:0015820; GO:0015821; GO:0071230; GO:1903714; GO:1903785 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:26319875}; Multi-pass membrane protein {ECO:0000255}. +P0AF45 YJBE_ECOLI Uncharacterized protein YjbE yjbE b4026 JW3986 yjbE 7,386 extracellular polysaccharide biosynthetic process [GO:0045226] extracellular polysaccharide biosynthetic process [GO:0045226] GO:0045226 +P0ACU7 YJDC_ECOLI HTH-type transcriptional regulator YjdC yjdC cutA3 b4135 JW5733 cutA3 yjdC 21,931 regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355 +P0A8I1 YQGF_ECOLI Putative pre-16S rRNA nuclease (EC 3.1.-.-) yqgF ruvX b2949 JW2916 ruvX yqgF 15,186 ribosome biogenesis [GO:0042254]; rRNA 5'-end processing [GO:0000967] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 3'-5'-exodeoxyribonuclease activity [GO:0008296]; ribosome biogenesis [GO:0042254]; rRNA 5'-end processing [GO:0000967] 3'-5'-exodeoxyribonuclease activity [GO:0008296] GO:0000967; GO:0005737; GO:0008296; GO:0042254 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00651}. +P77360 YPHC_ECOLI Uncharacterized zinc-type alcohol dehydrogenase-like protein YphC (EC 1.-.-.-) yphC b2545 JW5842 yphC 38,051 oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] GO:0008270; GO:0016491 +P0DPO8 YNFT_ECOLI Protein YnfT ynfT ynfQ b4748 ynfQ ynfT 4,013 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. +P76226 YNJF_ECOLI Inner membrane protein YnjF ynjF b1758 JW1747 ynjF 22,752 phospholipid biosynthetic process [GO:0008654] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; phospholipid biosynthetic process [GO:0008654] phosphotransferase activity, for other substituted phosphate groups [GO:0016780] GO:0005886; GO:0008654; GO:0016021; GO:0016780 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A855 TOLB_ECOLI Tol-Pal system protein TolB tolB b0740 JW5100 tolB 45,956 bacteriocin transport [GO:0043213]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to bacteriocin [GO:0071237]; protein import [GO:0017038]; protein transport [GO:0015031] cell division site [GO:0032153]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; protein-containing complex [GO:0032991] cell division site [GO:0032153]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; protein-containing complex [GO:0032991]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; bacteriocin transport [GO:0043213]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to bacteriocin [GO:0071237]; protein import [GO:0017038]; protein transport [GO:0015031] protein-containing complex binding [GO:0044877]; protein domain specific binding [GO:0019904] GO:0007049; GO:0015031; GO:0017038; GO:0019904; GO:0030288; GO:0032153; GO:0032991; GO:0042597; GO:0043213; GO:0044877; GO:0051301; GO:0071237 SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671, ECO:0000269|PubMed:2687247, ECO:0000269|PubMed:7929011}. Note=Partially associated with the outer membrane through a specific interaction with Pal (PubMed:7744736). Accumulates at cell constriction sites. Recruitment to the division site is dependent on FtsN activity (PubMed:17233825). {ECO:0000269|PubMed:17233825, ECO:0000269|PubMed:7744736}. +P37388 XYLG_ECOLI Xylose import ATP-binding protein XylG (EC 7.5.2.10) xylG b3567 JW3539 xylG 56,470 D-xylose metabolic process [GO:0042732]; D-xylose transmembrane transport [GO:0015753] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ABC-type D-xylose transporter activity [GO:0015614]; ATP binding [GO:0005524]; D-xylose transmembrane transporter activity [GO:0015148]; D-xylose metabolic process [GO:0042732]; D-xylose transmembrane transport [GO:0015753] ABC-type D-xylose transporter activity [GO:0015614]; ATP binding [GO:0005524]; D-xylose transmembrane transporter activity [GO:0015148] GO:0005524; GO:0005886; GO:0015148; GO:0015614; GO:0015753; GO:0042732 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01722}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01722}. +P0A858 TPIS_ECOLI Triosephosphate isomerase (TIM) (TPI) (EC 5.3.1.1) (Triose-phosphate isomerase) tpiA tpi b3919 JW3890 tpi tpiA 26,972 gluconeogenesis [GO:0006094]; glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; glycerol catabolic process [GO:0019563]; glycolytic process [GO:0006096] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; identical protein binding [GO:0042802]; triose-phosphate isomerase activity [GO:0004807]; gluconeogenesis [GO:0006094]; glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; glycerol catabolic process [GO:0019563]; glycolytic process [GO:0006096] identical protein binding [GO:0042802]; triose-phosphate isomerase activity [GO:0004807] GO:0004807; GO:0005829; GO:0006094; GO:0006096; GO:0016020; GO:0019563; GO:0042802; GO:0046166 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00147, ECO:0000305}. +P0ADZ7 YAJC_ECOLI Sec translocon accessory complex subunit YajC yajC b0407 JW0397 yajC 11,887 protein transport [GO:0015031] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; protein transport [GO:0015031] GO:0005887; GO:0015031 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:27435098}; Single-pass membrane protein {ECO:0000269|PubMed:16079137}. +P46122 YAJI_ECOLI Uncharacterized lipoprotein YajI yajI b0412 JW5056 yajI 19,560 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P37007 YAGA_ECOLI Uncharacterized protein YagA yagA b0267 JW0260 yagA 43,769 DNA integration [GO:0015074] cytosol [GO:0005829] cytosol [GO:0005829]; nucleic acid binding [GO:0003676]; DNA integration [GO:0015074] nucleic acid binding [GO:0003676] GO:0003676; GO:0005829; GO:0015074 +P77339 YAFT_ECOLI Uncharacterized lipoprotein YafT yafT b0217 JW0206 yafT 29,606 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P77700 YAHB_ECOLI Uncharacterized HTH-type transcriptional regulator YahB yahB b0316 JW0308 yahB 34,866 regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355 +P37049 YAEI_ECOLI Phosphodiesterase YaeI (EC 3.1.4.-) yaeI b0164 JW5014 yaeI 29,863 lipid A biosynthetic process [GO:0009245] metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081]; UDP-2,3-diacylglucosamine hydrolase activity [GO:0008758]; lipid A biosynthetic process [GO:0009245] metal ion binding [GO:0046872]; phosphoric diester hydrolase activity [GO:0008081]; UDP-2,3-diacylglucosamine hydrolase activity [GO:0008758] GO:0008081; GO:0008758; GO:0009245; GO:0046872 +P75676 YAFX_ECOLI Uncharacterized protein YafX yafX b0248 JW5022 yafX 17,420 +P75684 YAGP_ECOLI Putative LysR family substrate binding domain-containing protein YagP yagP b4695 JW0276 yagP 15,411 +P77427 YBEU_ECOLI Uncharacterized protein YbeU ybeU b0648 JW0643 ybeU 27,022 +P36682 YACH_ECOLI Uncharacterized protein YacH yacH b0117 JW0113 yacH 69,362 +P77400 YBAT_ECOLI Inner membrane transport protein YbaT ybaT b0486 JW0475 ybaT 45,659 amino acid transport [GO:0006865]; response to pH [GO:0009268]; stress response to copper ion [GO:1990169] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; amino acid transport [GO:0006865]; response to pH [GO:0009268]; stress response to copper ion [GO:1990169] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0006865; GO:0009268; GO:0016021; GO:0022857; GO:1990169 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +Q47138 YDFE_ECOLI Putative uncharacterized protein YdfE (ORF6) ydfE b1577 JW1568 ydfE 35,071 +P0ACX3 YDHR_ECOLI Putative monooxygenase YdhR (EC 1.-.-.-) ydhR b1667 JW1657 ydhR 11,288 cytosol [GO:0005829] cytosol [GO:0005829]; oxidoreductase activity [GO:0016491] oxidoreductase activity [GO:0016491] GO:0005829; GO:0016491 +P31453 YIDP_ECOLI Uncharacterized HTH-type transcriptional regulator YidP yidP b3684 JW3661 yidP 27,328 negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0045892 +P0AFS7 YDIK_ECOLI Putative transport protein YdiK ydiK b1688 JW1678 ydiK 39,841 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +Q47272 YLCG_ECOLI Uncharacterized protein YlcG ylcG b4509 JW5076 ylcG 5,494 +P52138 YFJW_ECOLI Uncharacterized protein YfjW yfjW b2642 JW2623 yfjW 64,196 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0ACM5 YEGW_ECOLI Uncharacterized HTH-type transcriptional regulator YegW yegW b2101 JW2088 yegW 28,277 negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0045892 +Q46843 YGHS_ECOLI Uncharacterized ATP-binding protein YghS yghS b2985 JW5491 yghS 26,347 ATP binding [GO:0005524] ATP binding [GO:0005524] GO:0005524 +P34209 YDCF_ECOLI Protein YdcF ydcF b1414 JW1411 ydcF 29,706 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 +P37767 YFHH_ECOLI Uncharacterized HTH-type transcriptional regulator YfhH yfhH b2561 JW2545 yfhH 30,708 carbohydrate derivative metabolic process [GO:1901135]; regulation of transcription, DNA-templated [GO:0006355] carbohydrate derivative binding [GO:0097367]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; carbohydrate derivative metabolic process [GO:1901135]; regulation of transcription, DNA-templated [GO:0006355] carbohydrate derivative binding [GO:0097367]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006355; GO:0097367; GO:1901135 +P76111 YDCZ_ECOLI Inner membrane protein YdcZ ydcZ b1447 JW1442 ydcZ 15,855 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P37908 YFJD_ECOLI UPF0053 inner membrane protein YfjD yfjD ypjE b4461 JW5415 b2612/b2613 ypjE yfjD 48,044 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; flavin adenine dinucleotide binding [GO:0050660] flavin adenine dinucleotide binding [GO:0050660] GO:0005886; GO:0016021; GO:0050660 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P33348 YEHL_ECOLI Uncharacterized protein YehL yehL b2119 JW5349 yehL 39,682 ATP binding [GO:0005524]; ATPase activity [GO:0016887] ATPase activity [GO:0016887]; ATP binding [GO:0005524] GO:0005524; GO:0016887 +Q9XB42 YKFH_ECOLI Uncharacterized protein YkfH ykfH b4504 JW5956 ykfH 8,581 +P39384 YJIM_ECOLI Putative dehydratase subunit YjiM (EC 4.-.-.-) yjiM b4335 JW5786 yjiM 42,743 cellular response to DNA damage stimulus [GO:0006974] lyase activity [GO:0016829]; cellular response to DNA damage stimulus [GO:0006974] lyase activity [GO:0016829] GO:0006974; GO:0016829 +P0ADD2 YJJB_ECOLI UPF0442 protein YjjB (Protein P-14) yjjB b4363 JW4327 yjjB 17,047 response to osmotic stress [GO:0006970]; response to peptide [GO:1901652]; succinate transport [GO:0015744] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; response to osmotic stress [GO:0006970]; response to peptide [GO:1901652]; succinate transport [GO:0015744] GO:0005886; GO:0005887; GO:0006970; GO:0015744; GO:1901652 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0AFQ7 YCFH_ECOLI Uncharacterized metal-dependent hydrolase YcfH (EC 3.1.-.-) ycfH b1100 JW1086 ycfH 29,809 cytosol [GO:0005829] cytosol [GO:0005829]; endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888]; metal ion binding [GO:0046872] endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888]; metal ion binding [GO:0046872] GO:0005829; GO:0016888; GO:0046872 +P0AF59 YJDI_ECOLI Uncharacterized protein YjdI yjdI b4126 JW4087 yjdI 8,550 +P39267 YJCZ_ECOLI Uncharacterized protein YjcZ yjcZ b4110 JW5729 yjcZ 32,899 +P39165 YCHO_ECOLI Uncharacterized protein YchO ychO ychP b1220 JW1211 ychP ychO 52,100 pathogenesis [GO:0009405] cell outer membrane [GO:0009279]; periplasmic space [GO:0042597] cell outer membrane [GO:0009279]; periplasmic space [GO:0042597]; pathogenesis [GO:0009405] GO:0009279; GO:0009405; GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P39284 YJEO_ECOLI Inner membrane protein YjeO yjeO b4158 JW4119 yjeO 12,638 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76023 YCHS_ECOLI Protein YchS ychS b1228 JW5881 ychS 9,607 +P0AF48 YJBQ_ECOLI UPF0047 protein YjbQ yjbQ b4056 JW4017 yjbQ 15,656 +P32157 YIIM_ECOLI Protein YiiM yiiM b3910 JW5559 yiiM 25,343 response to toxic substance [GO:0009636]; toxin catabolic process [GO:0009407] cytosol [GO:0005829] cytosol [GO:0005829]; catalytic activity [GO:0003824]; molybdenum ion binding [GO:0030151]; pyridoxal phosphate binding [GO:0030170]; response to toxic substance [GO:0009636]; toxin catabolic process [GO:0009407] catalytic activity [GO:0003824]; molybdenum ion binding [GO:0030151]; pyridoxal phosphate binding [GO:0030170] GO:0003824; GO:0005829; GO:0009407; GO:0009636; GO:0030151; GO:0030170 +P29013 YCGB_ECOLI Uncharacterized protein YcgB ycgB b1188 JW1177 ycgB 60,814 cellular response to DNA damage stimulus [GO:0006974] cellular response to DNA damage stimulus [GO:0006974] GO:0006974 +P08201 NIRB_ECOLI Nitrite reductase (NADH) large subunit (EC 1.7.1.15) nirB b3365 JW3328 nirB 93,121 anaerobic respiration [GO:0009061]; nitrate assimilation [GO:0042128] nitrite reductase complex [NAD(P)H] [GO:0009344] nitrite reductase complex [NAD(P)H] [GO:0009344]; 4 iron, 4 sulfur cluster binding [GO:0051539]; flavin adenine dinucleotide binding [GO:0050660]; heme binding [GO:0020037]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; nitrite reductase [NAD(P)H] activity [GO:0008942]; nitrite reductase NADH activity [GO:0106316]; anaerobic respiration [GO:0009061]; nitrate assimilation [GO:0042128] 4 iron, 4 sulfur cluster binding [GO:0051539]; flavin adenine dinucleotide binding [GO:0050660]; heme binding [GO:0020037]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; nitrite reductase [NAD(P)H] activity [GO:0008942]; nitrite reductase NADH activity [GO:0106316] GO:0008942; GO:0009061; GO:0009344; GO:0020037; GO:0042128; GO:0046872; GO:0050660; GO:0050661; GO:0051536; GO:0051539; GO:0106316 +P37013 NORR_ECOLI Anaerobic nitric oxide reductase transcription regulator NorR norR ygaA b2709 JW5843 ygaA norR 55,236 phosphorelay signal transduction system [GO:0000160]; positive regulation of DNA-templated transcription, initiation [GO:2000144] ATP binding [GO:0005524]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; ferrous iron binding [GO:0008198]; identical protein binding [GO:0042802]; nitric oxide binding [GO:0070026]; transcription factor binding [GO:0008134]; phosphorelay signal transduction system [GO:0000160]; positive regulation of DNA-templated transcription, initiation [GO:2000144] ATP binding [GO:0005524]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; ferrous iron binding [GO:0008198]; identical protein binding [GO:0042802]; nitric oxide binding [GO:0070026]; transcription factor binding [GO:0008134] GO:0000160; GO:0000986; GO:0003700; GO:0005524; GO:0008134; GO:0008198; GO:0042802; GO:0070026; GO:2000144 +P16692 PHNP_ECOLI Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase (EC 3.1.4.55) (Phosphoribosyl cyclic phosphodiesterase) phnP b4092 JW4053 phnP 27,848 organic phosphonate catabolic process [GO:0019700] 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity [GO:0103043]; manganese ion binding [GO:0030145]; organic phosphonate catabolic process [GO:0019700] 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity [GO:0103043]; manganese ion binding [GO:0030145] GO:0019700; GO:0030145; GO:0103043 +P07464 THGA_ECOLI Galactoside O-acetyltransferase (GAT) (EC 2.3.1.18) (Acetyl-CoA:galactoside 6-O-acetyltransferase) (Thiogalactoside acetyltransferase) (Thiogalactoside transacetylase) lacA b0342 JW0333 lacA 22,799 lactose biosynthetic process [GO:0005989] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; galactoside O-acetyltransferase activity [GO:0008870]; identical protein binding [GO:0042802]; lactose biosynthetic process [GO:0005989] galactoside O-acetyltransferase activity [GO:0008870]; identical protein binding [GO:0042802] GO:0005737; GO:0005989; GO:0008870; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:3922433}. +P69820 ULAC_ECOLI Ascorbate-specific PTS system EIIA component (Ascorbate-specific phosphotransferase enzyme IIA component) ulaC ptxA sgaA yjfU b4195 JW4153 ptxA sgaA yjfU ulaC 17,238 L-ascorbic acid transmembrane transport [GO:0015882]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; kinase activity [GO:0016301]; protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity [GO:0090585]; L-ascorbic acid transmembrane transport [GO:0015882]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity [GO:0090585] GO:0005737; GO:0009401; GO:0015882; GO:0016301; GO:0090585 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P25534 UBIH_ECOLI 2-octaprenyl-6-methoxyphenol hydroxylase (EC 1.14.13.-) ubiH visB b2907 JW2875 visB ubiH 42,288 response to light stimulus [GO:0009416]; response to oxidative stress [GO:0006979]; ubiquinone biosynthetic process [GO:0006744] cytoplasm [GO:0005737]; ubiquinone biosynthesis complex [GO:0110142] cytoplasm [GO:0005737]; ubiquinone biosynthesis complex [GO:0110142]; 2-octaprenyl-6-methoxyphenol hydroxylase activity [GO:0008681]; FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; response to light stimulus [GO:0009416]; response to oxidative stress [GO:0006979]; ubiquinone biosynthetic process [GO:0006744] 2-octaprenyl-6-methoxyphenol hydroxylase activity [GO:0008681]; FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709] GO:0005737; GO:0006744; GO:0006979; GO:0008681; GO:0009416; GO:0016491; GO:0016709; GO:0071949; GO:0110142 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30686758}. +P45531 TUSC_ECOLI Protein TusC (tRNA 2-thiouridine synthesizing protein C) tusC yheM b3344 JW3306 yheM tusC 13,045 tRNA wobble position uridine thiolation [GO:0002143] sulfurtransferase complex [GO:1990228] sulfurtransferase complex [GO:1990228]; tRNA wobble position uridine thiolation [GO:0002143] GO:0002143; GO:1990228 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P75728 UBIF_ECOLI 3-demethoxyubiquinol 3-hydroxylase (EC 1.14.99.60) (2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase) ubiF yleB b0662 JW0659 yleB ubiF 42,953 ubiquinone biosynthetic process [GO:0006744] cytoplasm [GO:0005737]; ubiquinone biosynthesis complex [GO:0110142] cytoplasm [GO:0005737]; ubiquinone biosynthesis complex [GO:0110142]; 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity [GO:0008682]; FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; ubiquinone biosynthetic process [GO:0006744] 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity [GO:0008682]; FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709] GO:0005737; GO:0006744; GO:0008682; GO:0016491; GO:0016705; GO:0016709; GO:0071949; GO:0110142 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30686758}. +P24215 UXUA_ECOLI Mannonate dehydratase (EC 4.2.1.8) (D-mannonate hydro-lyase) uxuA b4322 JW4285 uxuA 44,838 cellular response to DNA damage stimulus [GO:0006974]; D-glucuronate catabolic process [GO:0042840] ferrous iron binding [GO:0008198]; manganese ion binding [GO:0030145]; mannonate dehydratase activity [GO:0008927]; cellular response to DNA damage stimulus [GO:0006974]; D-glucuronate catabolic process [GO:0042840] ferrous iron binding [GO:0008198]; manganese ion binding [GO:0030145]; mannonate dehydratase activity [GO:0008927] GO:0006974; GO:0008198; GO:0008927; GO:0030145; GO:0042840 +P37669 WECH_ECOLI O-acetyltransferase WecH (EC 2.3.1.-) wecH yiaH b3561 JW3533 yiaH wecH 37,570 enterobacterial common antigen biosynthetic process [GO:0009246] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; O-acetyltransferase activity [GO:0016413]; enterobacterial common antigen biosynthetic process [GO:0009246] O-acetyltransferase activity [GO:0016413] GO:0005886; GO:0005887; GO:0009246; GO:0016413 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01949, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01949}. +Q2EEP9 YAFF_ECOLI Putative uncharacterized protein YafF yafF b4503 JW0208 yafF 6,953 +P0AAP7 YAIY_ECOLI Inner membrane protein YaiY yaiY b0379 JW0370 yaiY 11,424 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AAQ6 YBAA_ECOLI Uncharacterized protein YbaA ybaA b0456 JW0445 ybaA 13,318 +P75736 YBFF_ECOLI Esterase YbfF (EC 3.1.-.-) ybfF b0686 JW0673 ybfF 28,437 cytosol [GO:0005829] cytosol [GO:0005829]; carboxylic ester hydrolase activity [GO:0052689]; thiolester hydrolase activity [GO:0016790] carboxylic ester hydrolase activity [GO:0052689]; thiolester hydrolase activity [GO:0016790] GO:0005829; GO:0016790; GO:0052689 +P76231 YEAC_ECOLI Uncharacterized protein YeaC yeaC b1777 JW1766 yeaC 10,338 +P31142 THTM_ECOLI 3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2) (Rhodanese-like protein) sseA b2521 JW2505 sseA 30,812 DNA protection [GO:0042262]; response to antibiotic [GO:0046677]; response to oxidative stress [GO:0006979]; transsulfuration [GO:0019346] cytosol [GO:0005829] cytosol [GO:0005829]; 3-mercaptopyruvate sulfurtransferase activity [GO:0016784]; thiosulfate sulfurtransferase activity [GO:0004792]; DNA protection [GO:0042262]; response to antibiotic [GO:0046677]; response to oxidative stress [GO:0006979]; transsulfuration [GO:0019346] 3-mercaptopyruvate sulfurtransferase activity [GO:0016784]; thiosulfate sulfurtransferase activity [GO:0004792] GO:0004792; GO:0005829; GO:0006979; GO:0016784; GO:0019346; GO:0042262; GO:0046677 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A8E7 YAJQ_ECOLI UPF0234 protein YajQ yajQ b0426 JW5058 yajQ 18,344 cellular response to DNA damage stimulus [GO:0006974] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; nucleotide binding [GO:0000166]; tRNA binding [GO:0000049]; cellular response to DNA damage stimulus [GO:0006974] ATP binding [GO:0005524]; GTP binding [GO:0005525]; nucleotide binding [GO:0000166]; tRNA binding [GO:0000049] GO:0000049; GO:0000166; GO:0005524; GO:0005525; GO:0005829; GO:0006974 +P0AAY4 YBJH_ECOLI Uncharacterized protein YbjH ybjH b0843 JW0827 ybjH 9,971 +Q47158 YAFP_ECOLI Uncharacterized N-acetyltransferase YafP (EC 2.3.1.-) yafP b0234 JW0224 yafP 17,555 DNA repair [GO:0006281]; SOS response [GO:0009432] N-acetyltransferase activity [GO:0008080]; DNA repair [GO:0006281]; SOS response [GO:0009432] N-acetyltransferase activity [GO:0008080] GO:0006281; GO:0008080; GO:0009432 +P75694 YAHO_ECOLI Uncharacterized protein YahO yahO b0329 JW0321 yahO 9,895 response to radiation [GO:0009314] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; response to radiation [GO:0009314] GO:0009314; GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P37016 YADK_ECOLI Uncharacterized fimbrial-like protein YadK yadK b0136 JW0132 yadK 21,112 cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0007155; GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. +P36881 YADI_ECOLI Putative phosphotransferase enzyme IIA component YadI (Putative PTS system EIIA component) yadI b0129 JW0125 yadI 16,540 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737]; integral component of membrane [GO:0016021] cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; kinase activity [GO:0016301]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301] GO:0005737; GO:0009401; GO:0016021; GO:0016301 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P64594 YHAV_ECOLI Ribonuclease toxin YhaV (EC 3.1.-.-) (Ribonuclease YhaV) yhaV b3130 JW3099 yhaV 17,836 negative regulation of cell growth [GO:0030308]; RNA phosphodiester bond hydrolysis [GO:0090501]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502] toxin-antitoxin complex [GO:0110001] toxin-antitoxin complex [GO:0110001]; endoribonuclease activity [GO:0004521]; ribonuclease activity [GO:0004540]; ribosomal large subunit binding [GO:0043023]; negative regulation of cell growth [GO:0030308]; RNA phosphodiester bond hydrolysis [GO:0090501]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502] endoribonuclease activity [GO:0004521]; ribonuclease activity [GO:0004540]; ribosomal large subunit binding [GO:0043023] GO:0004521; GO:0004540; GO:0030308; GO:0043023; GO:0090501; GO:0090502; GO:0110001 +Q46811 YGFK_ECOLI Putative oxidoreductase YgfK (Putative oxidoreductase Fe-S subunit) ygfK b2878 JW5923 ygfK 115,582 ammonia assimilation cycle [GO:0019676]; glutamate biosynthetic process [GO:0006537] 4 iron, 4 sulfur cluster binding [GO:0051539]; glutamate synthase activity [GO:0015930]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; ammonia assimilation cycle [GO:0019676]; glutamate biosynthetic process [GO:0006537] 4 iron, 4 sulfur cluster binding [GO:0051539]; glutamate synthase activity [GO:0015930]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491] GO:0005506; GO:0006537; GO:0015930; GO:0016491; GO:0019676; GO:0051539 +P76513 YFDQ_ECOLI Uncharacterized protein YfdQ yfdQ b2360 JW2357 yfdQ 30,443 +P76509 YFDM_ECOLI Putative methyltransferase YfdM (EC 2.1.1.-) yfdM b2356 JW2352 yfdM 10,336 DNA binding [GO:0003677]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007] DNA binding [GO:0003677]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007] GO:0003677; GO:0009007 +P77378 YDIR_ECOLI Putative electron transfer flavoprotein subunit YdiR ydiR b1698 JW1688 ydiR 33,770 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539] electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539] electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660] GO:0009055; GO:0033539; GO:0050660 +P17994 YFAA_ECOLI Uncharacterized protein YfaA yfaA pufY b2230 JW2224 pufY yfaA 62,671 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P76466 YFAT_ECOLI Uncharacterized protein YfaT yfaT b2229 JW2223 yfaT 23,767 +P64548 YFIR_ECOLI Protein YfiR yfiR b2603 JW2584 yfiR 18,978 bacterial-type flagellum-dependent swarming motility [GO:0071978] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; bacterial-type flagellum-dependent swarming motility [GO:0071978] GO:0042597; GO:0071978 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P76064 YDAT_ECOLI Uncharacterized protein YdaT ydaT b1358 JW1353 ydaT 15,743 FtsZ-dependent cytokinesis [GO:0043093] FtsZ-dependent cytokinesis [GO:0043093] GO:0043093 +P45566 YHDT_ECOLI Uncharacterized membrane protein YhdT yhdT b3257 JW3225 yhdT 9,098 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P33354 YEHR_ECOLI Uncharacterized lipoprotein YehR yehR b2123 JW5351 yehR 16,594 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P67660 YHAJ_ECOLI Probable HTH-type transcriptional regulator YhaJ yhaJ b3105 JW3076 yhaJ 33,256 positive regulation of DNA-templated transcription, initiation [GO:2000144]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription activator activity [GO:0001216]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription activator activity [GO:0001216]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0001216; GO:0006355; GO:2000144 +P64451 YDCL_ECOLI Uncharacterized lipoprotein YdcL ydcL b1431 JW1427 ydcL 24,427 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P11290 YIBD_ECOLI Uncharacterized glycosyltransferase YibD (EC 2.4.-.-) yibD b3615 JW3590 yibD 40,524 cellular response to phosphate starvation [GO:0016036] membrane [GO:0016020] membrane [GO:0016020]; glucuronosyltransferase activity [GO:0015020]; transferase activity, transferring glycosyl groups [GO:0016757]; cellular response to phosphate starvation [GO:0016036] glucuronosyltransferase activity [GO:0015020]; transferase activity, transferring glycosyl groups [GO:0016757] GO:0015020; GO:0016020; GO:0016036; GO:0016757 +P0DPM8 YKGS_ECOLI Protein YkgS ykgS ykgU b4688 ykgU ykgS 4,630 +P76108 YDCS_ECOLI Bifunctional polyhydroxybutyrate synthase / ABC transporter periplasmic binding protein (Poly-3-hydroxybutyrate synthase) (PHB synthase) (EC 2.3.1.-) (cPHB synthase) ydcS b1440 JW1435 ydcS 42,295 DNA import into cell involved in transformation [GO:0009290]; polyamine transport [GO:0015846]; poly-hydroxybutyrate biosynthetic process [GO:0042619] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; polyamine binding [GO:0019808]; transferase activity, transferring acyl groups [GO:0016746]; DNA import into cell involved in transformation [GO:0009290]; poly-hydroxybutyrate biosynthetic process [GO:0042619]; polyamine transport [GO:0015846] polyamine binding [GO:0019808]; transferase activity, transferring acyl groups [GO:0016746] GO:0009290; GO:0015846; GO:0016746; GO:0019808; GO:0030288; GO:0042619 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:18640095}. +P39355 YJHE_ECOLI Putative uncharacterized protein YjhE yjhE b4282 yjhE 8,714 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P76361 YEER_ECOLI Inner membrane protein YeeR yeeR b2001 JW1983 yeeR 57,237 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77721 YDJF_ECOLI Uncharacterized HTH-type transcriptional regulator YdjF ydjF b1770 JW1759 ydjF 28,261 DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700 +P24203 YJIA_ECOLI P-loop guanosine triphosphatase YjiA (EC 3.6.-.-) (GTP-binding protein YjiA) yjiA b4352 JW5790 yjiA 35,660 cellular response to DNA damage stimulus [GO:0006974] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; transition metal ion binding [GO:0046914]; cellular response to DNA damage stimulus [GO:0006974] GTPase activity [GO:0003924]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; transition metal ion binding [GO:0046914] GO:0003924; GO:0005525; GO:0005737; GO:0005829; GO:0006974; GO:0042802; GO:0046914 +P32694 YJBM_ECOLI Uncharacterized protein YjbM yjbM b4048 JW4008 yjbM 26,673 +P32151 YIIG_ECOLI Uncharacterized protein YiiG yiiG b3896 JW3867 yiiG 39,294 +P76000 YCGI_ECOLI Putative uncharacterized protein YcgI ycgI ymgH b4521 JW1162/JW5179 b1173 ymgH ycgI 16,533 outer membrane [GO:0019867] outer membrane [GO:0019867] GO:0019867 +P75988 YCGX_ECOLI Uncharacterized protein YcgX ycgX b1161 JW1148 ycgX 15,769 +P32689 YJBH_ECOLI Uncharacterized lipoprotein YjbH yjbH b4029 JW3989 yjbH 78,491 extracellular polysaccharide biosynthetic process [GO:0045226] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; extracellular polysaccharide biosynthetic process [GO:0045226] GO:0005886; GO:0045226 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P0A8S5 USPB_ECOLI Universal stress protein B uspB yhiO b3494 JW3461 yhiO uspB 13,027 response to ethanol [GO:0045471] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; response to ethanol [GO:0045471] GO:0005886; GO:0016021; GO:0045471 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P45563 XAPA_ECOLI Purine nucleoside phosphorylase 2 (EC 2.4.2.1) (Inosine-guanosine phosphorylase) (Purine nucleoside phosphorylase II) (PNP II) (Xanthosine phosphorylase) xapA pndA b2407 JW2398 pndA xapA 29,835 deoxyguanosine catabolic process [GO:0006161]; deoxyinosine catabolic process [GO:0006149]; guanosine catabolic process [GO:0046115]; inosine catabolic process [GO:0006148]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleobase-containing small molecule metabolic process [GO:0055086]; protein hexamerization [GO:0034214]; purine nucleoside catabolic process [GO:0006152]; xanthosine catabolic process [GO:1903228] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; guanosine phosphorylase activity [GO:0047975]; identical protein binding [GO:0042802]; inosine nucleosidase activity [GO:0047724]; purine-nucleoside phosphorylase activity [GO:0004731]; deoxyguanosine catabolic process [GO:0006161]; deoxyinosine catabolic process [GO:0006149]; guanosine catabolic process [GO:0046115]; inosine catabolic process [GO:0006148]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleobase-containing small molecule metabolic process [GO:0055086]; protein hexamerization [GO:0034214]; purine nucleoside catabolic process [GO:0006152]; xanthosine catabolic process [GO:1903228] guanosine phosphorylase activity [GO:0047975]; identical protein binding [GO:0042802]; inosine nucleosidase activity [GO:0047724]; purine-nucleoside phosphorylase activity [GO:0004731] GO:0004731; GO:0005737; GO:0006148; GO:0006149; GO:0006152; GO:0006161; GO:0015949; GO:0034214; GO:0042802; GO:0046115; GO:0047724; GO:0047975; GO:0055086; GO:1903228 +P0DPN5 YBGU_ECOLI Protein YbgU ybgU b4735 ybgU 3,827 +P75843 YCAQ_ECOLI Uncharacterized protein YcaQ ycaQ b0916 JW0899 ycaQ 47,656 +P75616 YAAX_ECOLI Uncharacterized protein YaaX yaaX b0005 JW0004 yaaX 11,355 +P75682 YAGE_ECOLI Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE (KDG aldolase YagE) (EC 4.1.2.51) (Putative 2-dehydro-3-deoxy-D-pentonate aldolase YagE) (EC 4.1.2.28) yagE b0268 JW0261 yagE 32,530 aldonic acid catabolic process [GO:0046176] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 2-dehydro-3-deoxy-D-gluconate aldolase activity [GO:0061677]; 2-dehydro-3-deoxy-D-pentonate aldolase activity [GO:0047440]; identical protein binding [GO:0042802]; aldonic acid catabolic process [GO:0046176] 2-dehydro-3-deoxy-D-gluconate aldolase activity [GO:0061677]; 2-dehydro-3-deoxy-D-pentonate aldolase activity [GO:0047440]; identical protein binding [GO:0042802] GO:0005737; GO:0042802; GO:0046176; GO:0047440; GO:0061677 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0DP64 YBEM_ECOLI Putative protein YbeM ybeM b4581 JW0621 b0626 ybeM 20,482 nitrogen compound metabolic process [GO:0006807] nitrogen compound metabolic process [GO:0006807] GO:0006807 +P37003 YBFG_ECOLI Putative uncharacterized protein YbfG ybfG b0691 JW5094/JW5095 b0690 ybfG 24,604 +P77789 YDES_ECOLI Uncharacterized fimbrial-like protein YdeS ydeS b1504 JW1498 ydeS 18,949 cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. +P64463 YDFZ_ECOLI Putative selenoprotein YdfZ ydfZ b1541 JW1534 ydfZ 7,276 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P76154 YDFK_ECOLI Cold shock protein YdfK ydfK b1544 JW1537 ydfK 8,778 response to cold [GO:0009409] response to cold [GO:0009409] GO:0009409 +P0ADT2 YGIB_ECOLI UPF0441 protein YgiB ygiB b3037 JW5927 ygiB 23,479 cell outer membrane [GO:0009279] cell outer membrane [GO:0009279] GO:0009279 +P52060 YGGU_ECOLI UPF0235 protein YggU yggU b2953 JW5479 yggU 10,456 cytoplasm [GO:0005737] cytoplasm [GO:0005737] GO:0005737 +P29010 YDFD_ECOLI Uncharacterized protein YdfD ydfD b1576 JW1567 ydfD 6,842 viral release from host cell by cytolysis [GO:0044659] viral release from host cell by cytolysis [GO:0044659] GO:0044659 +P0AD30 YFCA_ECOLI Probable membrane transporter protein YfcA yfcA b2327 JW2324 yfcA 28,643 response to heat [GO:0009408] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; response to heat [GO:0009408] GO:0005887; GO:0009408 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76548 YFFQ_ECOLI Uncharacterized protein YffQ yffQ b2448 yffQ 13,819 +P0AA60 YGHB_ECOLI Inner membrane protein YghB yghB b3009 JW2976 yghB 24,134 FtsZ-dependent cytokinesis [GO:0043093]; transmembrane transport [GO:0055085] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; FtsZ-dependent cytokinesis [GO:0043093]; transmembrane transport [GO:0055085] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0022857; GO:0043093; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +Q46867 YGIZ_ECOLI Inner membrane protein YgiZ ygiZ b3027 JW2995 ygiZ 13,201 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P64590 YHAH_ECOLI Inner membrane protein YhaH yhaH b3103 JW3074 yhaH 14,281 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P52125 YFJJ_ECOLI Uncharacterized protein YfjJ yfjJ b2626 JW2607 yfjJ 24,561 +P76394 YEGJ_ECOLI Uncharacterized protein YegJ yegJ b2071 JW2056 yegJ 17,428 +P64488 YEAR_ECOLI Uncharacterized protein YeaR yeaR b1797 JW1786 yeaR 13,611 +P76347 YEEJ_ECOLI Uncharacterized protein YeeJ yeeJ b1978 JW5833 yeeJ 248,569 cell adhesion involved in biofilm formation [GO:0043708]; pathogenesis [GO:0009405] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; cell adhesion involved in biofilm formation [GO:0043708]; pathogenesis [GO:0009405] GO:0009279; GO:0009405; GO:0043708 +P0A9V5 YIAG_ECOLI Uncharacterized HTH-type transcriptional regulator YiaG yiaG b3555 JW3524 yiaG 11,033 DNA binding [GO:0003677] DNA binding [GO:0003677] GO:0003677 +P32700 YJCB_ECOLI Uncharacterized protein YjcB yjcB b4060 JW5718 yjcB 10,303 +P76322 YEDM_ECOLI Uncharacterized protein YedM yedM b1935 JW1920 yedM 13,396 +P58036 YJBS_ECOLI Uncharacterized protein YjbS yjbS b4621 b4054.1 yjbS 7,888 +P32135 YIHN_ECOLI Inner membrane protein YihN yihN b3874 JW3845 yihN 46,335 integral component of membrane [GO:0016021]; intrinsic component of membrane [GO:0031224]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; intrinsic component of membrane [GO:0031224]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857; GO:0031224 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P39385 YJIN_ECOLI Uncharacterized protein YjiN yjiN b4336 JW4299 yjiN 48,242 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0AFU6 YIIF_ECOLI Uncharacterized protein YiiF yiiF b3890 JW5563 yiiF 8,442 regulation of transcription, DNA-templated [GO:0006355] regulation of transcription, DNA-templated [GO:0006355] GO:0006355 +P37342 YJJI_ECOLI Uncharacterized protein YjjI yjjI yjjH b4380 JW4343 yjjH yjjI 58,020 anaerobic respiration [GO:0009061] anaerobic respiration [GO:0009061] GO:0009061 +P0AB43 YCGL_ECOLI Protein YcgL ycgL b1179 JW1168 ycgL 12,415 +P0DSG7 YHGP_ECOLI Protein YhgP yhgP b4789 yhgP 1,043 +Q6BEX5 YJDP_ECOLI Uncharacterized protein YjdP yjdP b4487 JW5890 yjdP 13,469 +P39383 YJIL_ECOLI Uncharacterized protein YjiL yjiL b4334 JW5785 yjiL 27,255 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0046872; GO:0051539 +P0AE45 YTFL_ECOLI UPF0053 inner membrane protein YtfL ytfL b4218 JW4177 ytfL 49,763 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; flavin adenine dinucleotide binding [GO:0050660] flavin adenine dinucleotide binding [GO:0050660] GO:0005886; GO:0016021; GO:0050660 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76559 YPFG_ECOLI Uncharacterized protein YpfG ypfG b2466 JW2450 ypfG 38,746 +P52143 YPJA_ECOLI Uncharacterized outer membrane protein YpjA ypjA b2647 JW5422 ypjA 157,500 cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] GO:0009279; GO:0016021 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +C1P618 YRBN_ECOLI Uncharacterized protein YrbN yrbN b4685 JW5531.1 yrbN 2,979 +P76117 YNCG_ECOLI Uncharacterized GST-like protein YncG yncG b1454 JW1449 yncG 23,321 glutathione metabolic process [GO:0006749] transferase activity [GO:0016740]; glutathione metabolic process [GO:0006749] transferase activity [GO:0016740] GO:0006749; GO:0016740 +Q2EES3 YOEF_ECOLI Protein YoeF yoeF b4538 JW5328 yoeF 12,969 cellular biogenic amine metabolic process [GO:0006576] ATP binding [GO:0005524]; cellular biogenic amine metabolic process [GO:0006576] ATP binding [GO:0005524] GO:0005524; GO:0006576 +P0DPP7 YQID_ECOLI Protein YqiD yqiD b4756 yqiD 6,810 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. +P0DPO4 YNAM_ECOLI Protein YnaM ynaM b4744 ynaM 4,013 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. +P39304 ULAD_ECOLI 3-keto-L-gulonate-6-phosphate decarboxylase UlaD (EC 4.1.1.85) (3-dehydro-L-gulonate-6-phosphate decarboxylase) (KGPDC) (L-ascorbate utilization protein D) ulaD sgaH yjfV b4196 JW4154 sgaH yjfV ulaD 23,578 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; L-ascorbic acid catabolic process [GO:0019854] 3-dehydro-L-gulonate-6-phosphate decarboxylase activity [GO:0033982]; magnesium ion binding [GO:0000287]; orotidine-5'-phosphate decarboxylase activity [GO:0004590]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; L-ascorbic acid catabolic process [GO:0019854] 3-dehydro-L-gulonate-6-phosphate decarboxylase activity [GO:0033982]; magnesium ion binding [GO:0000287]; orotidine-5'-phosphate decarboxylase activity [GO:0004590] GO:0000287; GO:0004590; GO:0006207; GO:0019854; GO:0033982 +P76387 WZC_ECOLI Tyrosine-protein kinase wzc (EC 2.7.10.-) wzc b2060 JW2045 wzc 79,343 colanic acid biosynthetic process [GO:0009242]; extracellular polysaccharide biosynthetic process [GO:0045226]; lipopolysaccharide biosynthetic process [GO:0009103]; peptidyl-tyrosine autophosphorylation [GO:0038083] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; identical protein binding [GO:0042802]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; colanic acid biosynthetic process [GO:0009242]; extracellular polysaccharide biosynthetic process [GO:0045226]; lipopolysaccharide biosynthetic process [GO:0009103]; peptidyl-tyrosine autophosphorylation [GO:0038083] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] GO:0004713; GO:0004714; GO:0005524; GO:0005886; GO:0005887; GO:0009103; GO:0009242; GO:0016887; GO:0038083; GO:0042802; GO:0045226 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0ACC9 WCAB_ECOLI Putative colanic acid biosynthesis acetyltransferase WcaB (EC 2.3.1.-) wcaB b2058 JW2043 wcaB 17,616 colanic acid biosynthetic process [GO:0009242]; cysteine biosynthetic process from serine [GO:0006535]; lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] cytosol [GO:0005829] cytosol [GO:0005829]; acetyltransferase activity [GO:0016407]; O-acetyltransferase activity [GO:0016413]; serine O-acetyltransferase activity [GO:0009001]; colanic acid biosynthetic process [GO:0009242]; cysteine biosynthetic process from serine [GO:0006535]; lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] acetyltransferase activity [GO:0016407]; O-acetyltransferase activity [GO:0016413]; serine O-acetyltransferase activity [GO:0009001] GO:0005829; GO:0006535; GO:0009001; GO:0009103; GO:0009242; GO:0016407; GO:0016413; GO:0045228 +P71237 WCAC_ECOLI Putative colanic acid biosynthesis glycosyl transferase WcaC wcaC b2057 JW2042 wcaC 45,260 colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] UDP-galactosyltransferase activity [GO:0035250]; colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] UDP-galactosyltransferase activity [GO:0035250] GO:0009103; GO:0009242; GO:0035250; GO:0045228 +P75822 YBJT_ECOLI Putative NAD(P)-binding protein YbjT ybjT b0869 JW5116 ybjT 53,707 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. +P0AA99 YAFK_ECOLI Putative L,D-transpeptidase YafK (EC 2.-.-.-) yafK b0224 JW0214 yafK 28,021 cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] hydrolase activity [GO:0016787]; transferase activity, transferring glycosyl groups [GO:0016757]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] hydrolase activity [GO:0016787]; transferase activity, transferring glycosyl groups [GO:0016757] GO:0008360; GO:0009252; GO:0016757; GO:0016787; GO:0071555 +P75859 YCBU_ECOLI Uncharacterized fimbrial-like protein YcbU ycbU b0942 JW0925 ycbU 18,914 cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0009289; GO:0043709; GO:0043711 +Q47151 YAFL_ECOLI Probable endopeptidase YafL (EC 3.4.-.-) (Uncharacterized lipoprotein YafL) yafL b0227 JW0217 yafL 28,785 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; cysteine-type peptidase activity [GO:0008234] cysteine-type peptidase activity [GO:0008234] GO:0005886; GO:0008234 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P75692 YAHM_ECOLI Uncharacterized protein YahM yahM b0327 JW5044 yahM 8,890 +P0AAU7 YBFE_ECOLI Uncharacterized protein YbfE ybfE b0685 JW5816 ybfE 11,280 cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355] cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355] GO:0006355; GO:0006974 +P28915 YBFC_ECOLI Uncharacterized protein YbfC ybfC b0704 JW0693 ybfC 21,961 +P31666 YADE_ECOLI Uncharacterized protein YadE yadE b0130 JW0126 yadE 46,315 carbohydrate metabolic process [GO:0005975] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]; carbohydrate metabolic process [GO:0005975] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810] GO:0005975; GO:0016810 +P0ACX0 YDGC_ECOLI Inner membrane protein YdgC ydgC b1607 JW1599 ydgC 12,323 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] GO:0005886; GO:0005887 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77804 YDGA_ECOLI Protein YdgA ydgA b1614 JW1606 ydgA 54,689 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; identical protein binding [GO:0042802] identical protein binding [GO:0042802] GO:0005886; GO:0042802 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000269|PubMed:16079137}; Periplasmic side {ECO:0000269|PubMed:16079137}. Note=Has been isolated in association with the inner membrane, suggesting it may be tethered to the membrane. +P65556 YFCD_ECOLI Uncharacterized Nudix hydrolase YfcD (EC 3.6.-.-) yfcD b2299 JW2296 yfcD 20,376 cytosol [GO:0005829] cytosol [GO:0005829]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; metal ion binding [GO:0046872] hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; metal ion binding [GO:0046872] GO:0005829; GO:0016818; GO:0046872 +P0AA49 YFDV_ECOLI Uncharacterized transporter YfdV yfdV b2372 JW2369 yfdV 33,616 transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transport [GO:0055085] GO:0005886; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0DSF5 YDGV_ECOLI Protein YdgV ydgV b4777 ydgV 3,906 +P42603 YGJV_ECOLI Inner membrane protein YgjV ygjV b3090 JW3061 ygjV 20,512 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] GO:0005886; GO:0005887 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76198 YDIN_ECOLI Inner membrane transport protein YdiN ydiN b1691 JW5274 ydiN 46,080 integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; uniporter activity [GO:0015292] uniporter activity [GO:0015292] GO:0005886; GO:0015292; GO:0016020; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P63417 YHBS_ECOLI Uncharacterized N-acetyltransferase YhbS (EC 2.3.1.-) yhbS b3156 JW3125 yhbS 18,534 cytosol [GO:0005829] cytosol [GO:0005829]; N-acetyltransferase activity [GO:0008080]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] N-acetyltransferase activity [GO:0008080]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] GO:0005829; GO:0008080; GO:0016747 +P11289 YFIL_ECOLI Uncharacterized protein YfiL (URF2) yfiL b2602 JW5412 yfiL 13,204 +A5A613 YCIY_ECOLI Uncharacterized protein YciY yciY b4595 yciY 7,102 +P75982 YMFQ_ECOLI Uncharacterized protein YmfQ (Uncharacterized protein YmfQ in lambdoid prophage e14 region) ymfQ b1153 JW1139 ymfQ 21,644 +P75973 YMFJ_ECOLI Uncharacterized protein YmfJ ymfJ b1144 JW1130 ymfJ 11,458 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P28917 YDCC_ECOLI H repeat-associated putative transposase YdcC (ORF-H) ydcC b1460 JW1455 ydcC 43,079 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0ADQ7 YGAM_ECOLI Uncharacterized protein YgaM ygaM b2672 JW2647 ygaM 11,847 cytosol [GO:0005829]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ribosome binding [GO:0043022] ribosome binding [GO:0043022] GO:0005829; GO:0005886; GO:0016021; GO:0043022 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P0ACV8 YMJA_ECOLI Uncharacterized protein YmjA ymjA b1295 JW1288 ymjA 9,321 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P75804 YLII_ECOLI Aldose sugar dehydrogenase YliI (Asd) (EC 1.1.5.-) (Soluble aldose sugar dehydrogenase YliI) yliI b0837 JW0821 yliI 41,054 cell outer membrane [GO:0009279]; outer membrane-bounded periplasmic space [GO:0030288] cell outer membrane [GO:0009279]; outer membrane-bounded periplasmic space [GO:0030288]; calcium ion binding [GO:0005509]; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [GO:0016901]; pyrroloquinoline quinone binding [GO:0070968] calcium ion binding [GO:0005509]; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [GO:0016901]; pyrroloquinoline quinone binding [GO:0070968] GO:0005509; GO:0009279; GO:0016901; GO:0030288; GO:0070968 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:16522795}. +P0DPO6 YDDY_ECOLI Protein YddY yddY b4746 yddY 1,481 +P31064 YEDE_ECOLI UPF0394 inner membrane protein YedE yedE b1929 JW1914 yedE 44,429 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] GO:0005886; GO:0005887 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P32134 YIHM_ECOLI Uncharacterized protein YihM yihM b3873 JW3844 yihM 36,942 +P27842 YIGF_ECOLI Uncharacterized protein YigF yigF b3817 JW3790 yigF 14,549 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 +P39352 YJHB_ECOLI Putative metabolite transport protein YjhB yjhB b4279 JW5768 yjhB 44,104 carboxylic acid transport [GO:0046942] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; carboxylic acid transmembrane transporter activity [GO:0046943]; carboxylic acid transport [GO:0046942] carboxylic acid transmembrane transporter activity [GO:0046943] GO:0005886; GO:0016021; GO:0046942; GO:0046943 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0AF54 YJCH_ECOLI Inner membrane protein YjcH yjcH b4068 JW4029 yjcH 11,672 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P32704 YJCF_ECOLI Uncharacterized protein YjcF yjcF b4066 JW4027 yjcF 49,378 +P68206 YJBJ_ECOLI UPF0337 protein YjbJ yjbJ b4045 JW4005 yjbJ 8,325 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P64481 YDJM_ECOLI Inner membrane protein YdjM ydjM b1728 JW5281 ydjM 22,350 cellular response to DNA damage stimulus [GO:0006974] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cellular response to DNA damage stimulus [GO:0006974] GO:0005886; GO:0006974; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P75748 YBGO_ECOLI Uncharacterized protein YbgO ybgO b0716 JW5098 ybgO 39,539 cell adhesion [GO:0007155] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion [GO:0007155] GO:0007155; GO:0009289 +P0AAX3 YBIJ_ECOLI Uncharacterized protein YbiJ ybiJ b0802 JW0787 ybiJ 8,568 cellular response to DNA damage stimulus [GO:0006974] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; cellular response to DNA damage stimulus [GO:0006974] GO:0006974; GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P64439 YBJM_ECOLI Inner membrane protein YbjM ybjM b0848 JW0832 ybjM 14,203 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77607 YAGL_ECOLI Uncharacterized protein YagL yagL b0278 JW0272 yagL 27,274 DNA binding [GO:0003677]; recombinase activity [GO:0000150] DNA binding [GO:0003677]; recombinase activity [GO:0000150] GO:0000150; GO:0003677 +P0AA95 YACC_ECOLI Uncharacterized protein YacC yacC b0122 JW0118 yacC 12,854 +P77598 YBCV_ECOLI Uncharacterized protein YbcV ybcV b0558 JW5081 ybcV 16,414 +P39263 YFCC_ECOLI Putative basic amino acid antiporter YfcC yfcC b2298 JW2295 yfcC 54,797 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297] antiporter activity [GO:0015297] GO:0005886; GO:0015297; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P76165 YDFX_ECOLI Protein YdfX ydfX b1568 JW1560 ydfX 10,976 +P45420 YHCD_ECOLI Uncharacterized outer membrane usher protein YhcD yhcD b3216 JW3183 yhcD 86,289 pilus assembly [GO:0009297] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; fimbrial usher porin activity [GO:0015473]; pilus assembly [GO:0009297] fimbrial usher porin activity [GO:0015473] GO:0009279; GO:0009297; GO:0015473; GO:0016021 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. +P77148 YDHS_ECOLI Uncharacterized protein YdhS ydhS b1668 JW1658 ydhS 60,755 +P0ADW6 YHCC_ECOLI Protein YhcC yhcC b3211 JW3178 yhcC 34,607 4 iron, 4 sulfur cluster binding [GO:0051539]; catalytic activity [GO:0003824]; metal ion binding [GO:0046872] 4 iron, 4 sulfur cluster binding [GO:0051539]; catalytic activity [GO:0003824]; metal ion binding [GO:0046872] GO:0003824; GO:0046872; GO:0051539 +P0ADU5 YGIW_ECOLI Protein YgiW ygiW b3024 JW2992 ygiW 14,011 cellular response to cadmium ion [GO:0071276]; cellular response to hydrogen peroxide [GO:0070301]; single-species biofilm formation on inanimate substrate [GO:0044011] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; cellular response to cadmium ion [GO:0071276]; cellular response to hydrogen peroxide [GO:0070301]; single-species biofilm formation on inanimate substrate [GO:0044011] GO:0042597; GO:0044011; GO:0070301; GO:0071276 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P76633 YGCW_ECOLI Uncharacterized oxidoreductase YgcW (EC 1.-.-.-) ygcW b2774 JW5443 ygcW 28,042 cellular response to DNA damage stimulus [GO:0006974] oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; cellular response to DNA damage stimulus [GO:0006974] oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] GO:0006974; GO:0016616 +P33666 YDBA_ECOLI Exported protein YdbA ydbA b4492 JW5802/JW1402 b1401/b1405 ydbA 87,130 extracellular region [GO:0005576] extracellular region [GO:0005576] GO:0005576 SUBCELLULAR LOCATION: Secreted {ECO:0000305}. +P77546 YDAV_ECOLI Uncharacterized protein YdaV ydaV b1360 JW1355 ydaV 28,128 DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271] ATP binding [GO:0005524]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271] ATP binding [GO:0005524] GO:0005524; GO:0006260; GO:0006271 +Q46909 YGCS_ECOLI Inner membrane metabolite transport protein YgcS ygcS b2771 JW5845 ygcS 48,234 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P09154 YMFS_ECOLI Uncharacterized protein YmfS ymfS b1155 JW5171 ymfS 15,434 +P76243 YEAO_ECOLI Uncharacterized protein YeaO yeaO b1792 JW1781 yeaO 13,386 +P33341 YEHB_ECOLI Outer membrane usher protein YehB yehB b2109 JW2096 yehB 92,282 cellular response to DNA damage stimulus [GO:0006974]; pilus assembly [GO:0009297] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; fimbrial usher porin activity [GO:0015473]; cellular response to DNA damage stimulus [GO:0006974]; pilus assembly [GO:0009297] fimbrial usher porin activity [GO:0015473] GO:0006974; GO:0009279; GO:0009297; GO:0015473; GO:0016021 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. +Q46803 YGEW_ECOLI Putative carbamoyltransferase YgeW (EC 2.1.3.-) (UTCase) ygeW b2870 JW5463 ygeW 44,187 arginine biosynthetic process via ornithine [GO:0042450]; citrulline biosynthetic process [GO:0019240] amino acid binding [GO:0016597]; ornithine carbamoyltransferase activity [GO:0004585]; arginine biosynthetic process via ornithine [GO:0042450]; citrulline biosynthetic process [GO:0019240] amino acid binding [GO:0016597]; ornithine carbamoyltransferase activity [GO:0004585] GO:0004585; GO:0016597; GO:0019240; GO:0042450 +P37757 YDDE_ECOLI Uncharacterized isomerase YddE (EC 5.1.-.-) (ORFB) yddE b1464 JW1459 yddE 32,319 biosynthetic process [GO:0009058] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; isomerase activity [GO:0016853]; biosynthetic process [GO:0009058] isomerase activity [GO:0016853] GO:0005737; GO:0009058; GO:0016853 +P0AG27 YIBN_ECOLI Uncharacterized protein YibN yibN b3611 JW3586 yibN 15,596 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P39389 YJIR_ECOLI Uncharacterized HTH-type transcriptional regulator YjiR yjiR b4340 JW4303 yjiR 53,047 alpha-amino acid metabolic process [GO:1901605]; biosynthetic process [GO:0009058] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]; alpha-amino acid metabolic process [GO:1901605]; biosynthetic process [GO:0009058] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] GO:0003677; GO:0003700; GO:0008483; GO:0009058; GO:0030170; GO:1901605 +P32703 YJCE_ECOLI Uncharacterized Na(+)/H(+) exchanger YjcE yjcE b4065 JW4026 yjcE 60,523 potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] GO:0005886; GO:0015385; GO:0015386; GO:0016021; GO:0051453; GO:0071805; GO:0098719 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P16681 YJDN_ECOLI Protein YjdN yjdN phnB b4107 JW4068 phnB yjdN 16,171 +P46853 YHHX_ECOLI Uncharacterized oxidoreductase YhhX (EC 1.-.-.-) yhhX b3440 JW3403 yhhX 38,765 cytosol [GO:0005829] cytosol [GO:0005829]; nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491] nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491] GO:0000166; GO:0005829; GO:0016491 +P76017 YCGV_ECOLI Uncharacterized protein YcgV ycgV b1202 JW1193 ycgV 99,685 cell adhesion involved in biofilm formation [GO:0043708] outer membrane [GO:0019867] outer membrane [GO:0019867]; cell adhesion involved in biofilm formation [GO:0043708] GO:0019867; GO:0043708 +P76012 YCGY_ECOLI Uncharacterized protein YcgY ycgY b1196 JW1185 ycgY 16,695 +P0AAV0 YBGE_ECOLI Uncharacterized protein YbgE ybgE b0735 JW0725 ybgE 10,932 +P0AAZ7 YCAR_ECOLI UPF0434 protein YcaR ycaR b0917 JW0900 ycaR 6,855 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P0AB26 YCEB_ECOLI Uncharacterized lipoprotein YceB yceB b1063 JW1050 yceB 20,500 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P31058 YADC_ECOLI Uncharacterized fimbrial-like protein YadC yadC b0135 JW0131 yadC 44,899 cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; cellular response to DNA damage stimulus [GO:0006974]; pilus organization [GO:0043711]; response to antibiotic [GO:0046677] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; cellular response to DNA damage stimulus [GO:0006974]; pilus organization [GO:0043711]; response to antibiotic [GO:0046677] GO:0006974; GO:0007155; GO:0009289; GO:0043709; GO:0043711; GO:0046677 SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. +P77698 YBCK_ECOLI Uncharacterized protein YbcK ybcK b0544 JW0532 ybcK 57,527 DNA recombination [GO:0006310] DNA binding [GO:0003677]; recombinase activity [GO:0000150]; DNA recombination [GO:0006310] DNA binding [GO:0003677]; recombinase activity [GO:0000150] GO:0000150; GO:0003677; GO:0006310 +P76498 YFCO_ECOLI Uncharacterized protein YfcO yfcO b2332 JW2329 yfcO 30,260 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P0AGK4 YHBY_ECOLI RNA-binding protein YhbY yhbY b3180 JW3147 yhbY 10,784 ribosomal large subunit assembly [GO:0000027]; ribosomal small subunit assembly [GO:0000028]; rRNA 5'-end processing [GO:0000967] cytosol [GO:0005829] cytosol [GO:0005829]; preribosome binding [GO:1990275]; RNA binding [GO:0003723]; ribosomal large subunit assembly [GO:0000027]; ribosomal small subunit assembly [GO:0000028]; rRNA 5'-end processing [GO:0000967] preribosome binding [GO:1990275]; RNA binding [GO:0003723] GO:0000027; GO:0000028; GO:0000967; GO:0003723; GO:0005829; GO:1990275 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16980477}. Note=Has been seen to comigrate with the 50S ribosomal subunit in sucrose gradients. +P42599 YGJR_ECOLI Uncharacterized oxidoreductase YgjR (EC 1.-.-.-) ygjR b3087 JW3058 ygjR 36,214 nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491] nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491] GO:0000166; GO:0016491 +P42640 YHBX_ECOLI Putative transferase YhbX (EC 2.-.-.-) yhbX b3173 JW5534 yhbX 60,753 lipopolysaccharide core region biosynthetic process [GO:0009244] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; phosphotransferase activity, phosphate group as acceptor [GO:0016776]; sulfuric ester hydrolase activity [GO:0008484]; lipopolysaccharide core region biosynthetic process [GO:0009244] phosphotransferase activity, phosphate group as acceptor [GO:0016776]; sulfuric ester hydrolase activity [GO:0008484] GO:0005886; GO:0008484; GO:0009244; GO:0016021; GO:0016776 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P31446 YIDI_ECOLI Inner membrane protein YidI yidI b3677 JW3653 yidI 15,729 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0DPN4 YLDA_ECOLI Protein YldA yldA b4734 yldA 3,258 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. +P78271 YFES_ECOLI Uncharacterized protein YfeS yfeS b2420 JW2413 yfeS 28,243 +P45422 YHCF_ECOLI Uncharacterized protein YhcF yhcF b3219 JW3188 yhcF 24,900 cellular response to DNA damage stimulus [GO:0006974] cellular response to DNA damage stimulus [GO:0006974] GO:0006974 +P0AB55 YCII_ECOLI Protein YciI yciI b1251 JW1243 yciI 10,602 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P0DPC8 YMCF_ECOLI Protein YmcF ymcF b4723 ymcF 7,104 +P32677 YIJO_ECOLI Uncharacterized HTH-type transcriptional regulator YijO yijO b3954 JW3926 yijO 32,149 DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0043565 +P76204 YDIV_ECOLI Putative anti-FlhC(2)FlhD(4) factor YdiV (c-di-GMP regulator CdgR) ydiV cdgR b1707 JW1697 cdgR ydiV 27,046 negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription regulatory region DNA binding [GO:2000678] transcription factor binding [GO:0008134]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription regulatory region DNA binding [GO:2000678] transcription factor binding [GO:0008134] GO:0008134; GO:0043433; GO:1902201; GO:2000678 +P46126 YFIM_ECOLI Uncharacterized protein YfiM yfiM b2586 JW2570 yfiM 11,805 +Q46798 YGER_ECOLI Uncharacterized lipoprotein YgeR ygeR b2865 JW2833 ygeR 26,565 septum digestion after cytokinesis [GO:0000920] cell division site [GO:0032153]; cell outer membrane [GO:0009279]; plasma membrane [GO:0005886] cell division site [GO:0032153]; cell outer membrane [GO:0009279]; plasma membrane [GO:0005886]; metalloendopeptidase activity [GO:0004222]; septum digestion after cytokinesis [GO:0000920] metalloendopeptidase activity [GO:0004222] GO:0000920; GO:0004222; GO:0005886; GO:0009279; GO:0032153 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. Note=Slightly enriched at the septal ring. +P76628 YGAY_ECOLI Putative uncharacterized transporter YgaY ygaY b2681 JW2655 b2680 ygaY 41,655 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +Q46793 YGEN_ECOLI Putative uncharacterized protein YgeN ygeN ygeM b2858 JW5459/JW5460 b2857 ygeM ygeN 27,365 +P27862 YIGZ_ECOLI IMPACT family member YigZ yigZ b3848 JW5577 yigZ 21,757 regulation of translational initiation [GO:0006446] regulation of translational initiation [GO:0006446] GO:0006446 +P0DSE8 YLJB_ECOLI Protein YljB yljB b4770 yljB 2,707 +P77280 YDJJ_ECOLI Uncharacterized zinc-type alcohol dehydrogenase-like protein YdjJ (EC 1.-.-.-) ydjJ b1774 JW1763 ydjJ 37,701 oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] GO:0008270; GO:0016491 +P31437 YICL_ECOLI Uncharacterized inner membrane transporter YicL yicL b3660 JW3634 yicL 33,113 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P32162 YIIS_ECOLI UPF0381 protein YiiS yiiS b3922 JW3893 yiiS 10,776 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P0DSG6 YHGO_ECOLI Protein YhgO yhgO b4788 yhgO 1,576 +P0ADD7 YJJQ_ECOLI Putative transcription factor YjjQ yjjQ b4365 JW4329 yjjQ 27,032 regulation of transcription, DNA-templated [GO:0006355]; response to methylglyoxal [GO:0051595] DNA binding [GO:0003677]; regulation of transcription, DNA-templated [GO:0006355]; response to methylglyoxal [GO:0051595] DNA binding [GO:0003677] GO:0003677; GO:0006355; GO:0051595 +P39368 YJHQ_ECOLI Uncharacterized N-acetyltransferase YjhQ (EC 2.3.1.-) yjhQ b4307 JW4269 yjhQ 19,957 N-acetyltransferase activity [GO:0008080]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] N-acetyltransferase activity [GO:0008080]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] GO:0008080; GO:0016747 +P37641 YHJC_ECOLI Uncharacterized HTH-type transcriptional regulator YhjC yhjC b3521 JW3489 yhjC 33,330 transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0006351; GO:0043565 +P0AF76 YJFI_ECOLI Uncharacterized protein YjfI yjfI b4181 JW4139 yjfI 14,935 +C1P609 YOHP_ECOLI Uncharacterized membrane protein YohP yohP b4679 JW5358.1 yohP 3,092 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:19121005, ECO:0000305|PubMed:21778229}; Single-pass membrane protein {ECO:0000269|PubMed:19121005, ECO:0000269|PubMed:21778229}. Note=May be able to insert into the membrane in both orientations. Depletion of SecE or YidC does not affect membrane insertion. +Q46856 YQHD_ECOLI Alcohol dehydrogenase YqhD (EC 1.1.1.-) yqhD b3011 JW2978 yqhD 42,097 response to reactive oxygen species [GO:0000302] cytosol [GO:0005829] cytosol [GO:0005829]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; alcohol dehydrogenase [NAD(P)+] activity [GO:0018455]; identical protein binding [GO:0042802]; methylglyoxal reductase (NADPH-dependent, acetol producing) [GO:1990002]; zinc ion binding [GO:0008270]; response to reactive oxygen species [GO:0000302] alcohol dehydrogenase (NADP+) activity [GO:0008106]; alcohol dehydrogenase [NAD(P)+] activity [GO:0018455]; identical protein binding [GO:0042802]; methylglyoxal reductase (NADPH-dependent, acetol producing) [GO:1990002]; zinc ion binding [GO:0008270] GO:0000302; GO:0005829; GO:0008106; GO:0008270; GO:0018455; GO:0042802; GO:1990002 +A5A619 YOJO_ECOLI Protein YojO yojO b4604 yojO 6,218 +P65298 YQHH_ECOLI Uncharacterized lipoprotein YqhH yqhH b3014 JW2982 yqhH 9,513 intrinsic component of cell outer membrane [GO:0031230] intrinsic component of cell outer membrane [GO:0031230]; peptidoglycan binding [GO:0042834] peptidoglycan binding [GO:0042834] GO:0031230; GO:0042834 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250|UniProtKB:P69776}; Lipid-anchor {ECO:0000250|UniProtKB:P69776}. Cell outer membrane {ECO:0000250|UniProtKB:P69776}; Peptidoglycan-anchor {ECO:0000250|UniProtKB:P69776}. +P64423 ZNTB_ECOLI Zinc transport protein ZntB zntB ydaN b1342 JW1336 ydaN zntB 36,612 zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; cobalt ion binding [GO:0050897]; cobalt ion transmembrane transporter activity [GO:0015087]; magnesium ion binding [GO:0000287]; magnesium ion transmembrane transporter activity [GO:0015095]; solute:proton symporter activity [GO:0015295]; zinc efflux transmembrane transporter activity [GO:0022883]; zinc ion transmembrane transporter activity [GO:0005385]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577] cobalt ion binding [GO:0050897]; cobalt ion transmembrane transporter activity [GO:0015087]; magnesium ion binding [GO:0000287]; magnesium ion transmembrane transporter activity [GO:0015095]; solute:proton symporter activity [GO:0015295]; zinc efflux transmembrane transporter activity [GO:0022883]; zinc ion transmembrane transporter activity [GO:0005385] GO:0000287; GO:0005385; GO:0005887; GO:0015087; GO:0015095; GO:0015295; GO:0022883; GO:0050897; GO:0071577; GO:0071578 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A9W9 YRDA_ECOLI Protein YrdA yrdA b3279 JW5710 yrdA 20,245 cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] GO:0005829; GO:0008270; GO:0032991; GO:0042802 +P04693 TYRB_ECOLI Aromatic-amino-acid aminotransferase (ARAT) (AROAT) (EC 2.6.1.57) (Beta-methylphenylalanine transaminase) (EC 2.6.1.107) tyrB b4054 JW4014 tyrB 43,538 aspartate biosynthetic process [GO:0006532]; leucine biosynthetic process [GO:0009098]; L-phenylalanine biosynthetic process from chorismate via phenylpyruvate [GO:0033585]; tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate [GO:0019292] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; aromatic-amino-acid:2-oxoglutarate aminotransferase activity [GO:0008793]; identical protein binding [GO:0042802]; L-leucine:2-oxoglutarate aminotransferase activity [GO:0050048]; L-phenylalanine:2-oxoglutarate aminotransferase activity [GO:0080130]; L-tyrosine:2-oxoglutarate aminotransferase activity [GO:0004838]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]; aspartate biosynthetic process [GO:0006532]; L-phenylalanine biosynthetic process from chorismate via phenylpyruvate [GO:0033585]; leucine biosynthetic process [GO:0009098]; tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate [GO:0019292] aromatic-amino-acid:2-oxoglutarate aminotransferase activity [GO:0008793]; identical protein binding [GO:0042802]; L-leucine:2-oxoglutarate aminotransferase activity [GO:0050048]; L-phenylalanine:2-oxoglutarate aminotransferase activity [GO:0080130]; L-tyrosine:2-oxoglutarate aminotransferase activity [GO:0004838]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] GO:0004838; GO:0005737; GO:0005829; GO:0006532; GO:0008483; GO:0008793; GO:0009098; GO:0019292; GO:0030170; GO:0033585; GO:0042802; GO:0050048; GO:0080130 SUBCELLULAR LOCATION: Cytoplasm. +P36879 YADG_ECOLI Uncharacterized ABC transporter ATP-binding protein YadG yadG b0127 JW0123 yadG 34,647 response to X-ray [GO:0010165] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; response to X-ray [GO:0010165] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0010165; GO:0042626 +P77599 YFCS_ECOLI Probable fimbrial chaperone YfcS yfcS b2336 JW2333 yfcS 27,728 cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] GO:0030288; GO:0043711; GO:0061077; GO:0071555 SUBCELLULAR LOCATION: Periplasm {ECO:0000250}. +P0A8R7 YCJF_ECOLI UPF0283 membrane protein YcjF ycjF b1322 JW1315 ycjF 39,392 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0DPN9 YMGL_ECOLI Protein YmgL ymgL b4739 ymgL 4,303 +P0AD10 YECJ_ECOLI Uncharacterized protein YecJ yecJ b4537 JW1891 yecJ 9,123 +P23305 YIGA_ECOLI Uncharacterized protein YigA yigA b3810 JW3783 yigA 26,729 +P0AEH8 YJIG_ECOLI Inner membrane protein YjiG yjiG b4329 JW4292 yjiG 16,193 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P33222 YJFC_ECOLI Putative acid--amine ligase YjfC (EC 6.3.1.-) yjfC b4186 JW4144 yjfC 45,020 ATP binding [GO:0005524]; ligase activity [GO:0016874]; metal ion binding [GO:0046872] ATP binding [GO:0005524]; ligase activity [GO:0016874]; metal ion binding [GO:0046872] GO:0005524; GO:0016874; GO:0046872 +P0ACN2 YTFH_ECOLI Uncharacterized HTH-type transcriptional regulator YtfH ytfH b4212 JW5747 ytfH 14,075 DNA binding [GO:0003677] DNA binding [GO:0003677] GO:0003677 +P0DPP2 YOAL_ECOLI Protein YoaL yoaL b4751 yoaL 6,058 +P77031 YQCE_ECOLI Inner membrane protein YqcE yqcE yqcF b2775 JW2746 yqcF yqcE 46,831 integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005887; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76223 YNJB_ECOLI Protein YnjB ynjB b1754 JW5284 ynjB 42,845 +P64445 YNAJ_ECOLI Uncharacterized protein YnaJ ynaJ b1332 JW1326 ynaJ 9,339 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +C1P606 YOEI_ECOLI Uncharacterized protein YoeI yoeI b4678 JW5330.1 yoeI 2,242 +P0AC51 ZUR_ECOLI Zinc uptake regulation protein (Zinc uptake regulator) zur yjbK b4046 JW5714 yjbK zur 19,254 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of secondary metabolite biosynthetic process [GO:1900376]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; zinc ion binding [GO:0008270]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of secondary metabolite biosynthetic process [GO:1900376]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; zinc ion binding [GO:0008270] GO:0000976; GO:0001217; GO:0003700; GO:0005829; GO:0006351; GO:0008270; GO:0032993; GO:0042802; GO:0045892; GO:1900376 +P0A8H3 ZUPT_ECOLI Zinc transporter ZupT zupT ygiE b3040 JW3008 ygiE zupT 26,485 cadmium ion transmembrane transport [GO:0070574]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cadmium ion transmembrane transporter activity [GO:0015086]; cobalt ion transmembrane transporter activity [GO:0015087]; copper ion transmembrane transporter activity [GO:0005375]; ferrous iron transmembrane transporter activity [GO:0015093]; manganese ion transmembrane transporter activity [GO:0005384]; zinc ion transmembrane transporter activity [GO:0005385]; cadmium ion transmembrane transport [GO:0070574]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829] cadmium ion transmembrane transporter activity [GO:0015086]; cobalt ion transmembrane transporter activity [GO:0015087]; copper ion transmembrane transporter activity [GO:0005375]; ferrous iron transmembrane transporter activity [GO:0015093]; manganese ion transmembrane transporter activity [GO:0005384]; zinc ion transmembrane transporter activity [GO:0005385] GO:0005375; GO:0005384; GO:0005385; GO:0005886; GO:0006829; GO:0015086; GO:0015087; GO:0015093; GO:0016020; GO:0016021; GO:0070574; GO:0071577 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P14377 ZRAS_ECOLI Sensor protein ZraS (EC 2.7.13.3) zraS hydH b4003 JW3967 hydH zraS 51,032 cellular response to cell envelope stress [GO:0036460]; cellular response to lead ion [GO:0071284]; cellular response to zinc ion [GO:0071294]; peptidyl-histidine phosphorylation [GO:0018106]; protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673]; cellular response to cell envelope stress [GO:0036460]; cellular response to lead ion [GO:0071284]; cellular response to zinc ion [GO:0071294]; peptidyl-histidine phosphorylation [GO:0018106]; protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165] ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673] GO:0000155; GO:0004673; GO:0005524; GO:0005886; GO:0005887; GO:0007165; GO:0016020; GO:0018106; GO:0036460; GO:0046777; GO:0071284; GO:0071294 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0ACT6 UIDR_ECOLI HTH-type transcriptional regulator UidR (Gus operon repressor) (Uid operon repressor) uidR gusR b1618 JW1610 gusR uidR 21,799 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006351; GO:0006355; GO:0045892 +Q46800 XDHB_ECOLI Putative xanthine dehydrogenase FAD-binding subunit XdhB (EC 1.17.1.4) xdhB ygeT b2867 JW2835 ygeT xdhB 31,557 hypoxanthine catabolic process [GO:0009114]; purine ribonucleoside salvage [GO:0006166] FAD binding [GO:0071949]; xanthine dehydrogenase activity [GO:0004854]; hypoxanthine catabolic process [GO:0009114]; purine ribonucleoside salvage [GO:0006166] FAD binding [GO:0071949]; xanthine dehydrogenase activity [GO:0004854] GO:0004854; GO:0006166; GO:0009114; GO:0071949 +P38506 XNI_ECOLI Flap endonuclease Xni (FEN) (EC 3.1.-.-) (Exonuclease IX) (ExoIX) ygdG exo xni b2798 JW5446 exo xni ygdG 28,166 DNA replication, Okazaki fragment processing [GO:0033567] 5'-flap endonuclease activity [GO:0017108]; DNA binding [GO:0003677]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; DNA replication, Okazaki fragment processing [GO:0033567] 5'-flap endonuclease activity [GO:0017108]; DNA binding [GO:0003677]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955] GO:0000287; GO:0003677; GO:0017108; GO:0030955; GO:0033567 +P0AAC4 YBHL_ECOLI Inner membrane protein YbhL ybhL b0786 JW0769 ybhL 25,902 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P64442 YCEO_ECOLI Uncharacterized protein YceO yceO b1058 JW1045 yceO 5,897 response to acidic pH [GO:0010447] response to acidic pH [GO:0010447] GO:0010447 +P21829 YBHA_ECOLI Pyridoxal phosphate phosphatase YbhA (PLP phosphatase) (EC 3.1.3.74) ybhA b0766 JW0749 ybhA 30,201 pyridoxal phosphate catabolic process [GO:0032361] cytosol [GO:0005829] cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; pyridoxal phosphatase activity [GO:0033883]; sugar-phosphatase activity [GO:0050308]; pyridoxal phosphate catabolic process [GO:0032361] magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; pyridoxal phosphatase activity [GO:0033883]; sugar-phosphatase activity [GO:0050308] GO:0000287; GO:0005829; GO:0016773; GO:0016791; GO:0032361; GO:0033883; GO:0050308 +P0ADA5 YAJG_ECOLI Uncharacterized lipoprotein YajG yajG b0434 JW0424 yajG 20,950 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P77735 YAJO_ECOLI 1-deoxyxylulose-5-phosphate synthase YajO (EC 1.1.-.-) yajO b0419 JW0409 yajO 36,420 thiamine metabolic process [GO:0006772] cytosol [GO:0005829] cytosol [GO:0005829]; D-threo-aldose 1-dehydrogenase activity [GO:0047834]; thiamine metabolic process [GO:0006772] D-threo-aldose 1-dehydrogenase activity [GO:0047834] GO:0005829; GO:0006772; GO:0047834 +P46119 YBJC_ECOLI Uncharacterized protein YbjC ybjC b0850 JW0834 ybjC 10,521 response to butan-1-ol [GO:1901422]; response to paraquat [GO:1901562] membrane [GO:0016020] membrane [GO:0016020]; response to butan-1-ol [GO:1901422]; response to paraquat [GO:1901562] GO:0016020; GO:1901422; GO:1901562 +P75620 YAAY_ECOLI Uncharacterized protein YaaY yaaY b0024 JW5003 yaaY 7,890 cellular response to DNA damage stimulus [GO:0006974] cellular response to DNA damage stimulus [GO:0006974] GO:0006974 +P0AAQ0 YAIZ_ECOLI Uncharacterized protein YaiZ yaiZ b0380 JW5053 yaiZ 8,097 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P75910 YCDU_ECOLI Uncharacterized protein YcdU ycdU b1029 JW1015 ycdU 38,668 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0ADT8 YGIM_ECOLI Uncharacterized protein YgiM ygiM b3055 JW3027 ygiM 23,076 cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887] cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887] GO:0005829; GO:0005887 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P45508 YFAL_ECOLI Probable autotransporter YfaL [Cleaved into: Probable secreted autotransporter protein YfaL; Probable autotransporter YfaL translocator] yfaL yfaF yfaJ yfaK b2233 JW2227 yfaF yfaJ yfaK yfaL 131,153 cell adhesion involved in single-species biofilm formation [GO:0043709]; response to UV [GO:0009411] cell outer membrane [GO:0009279]; cell surface [GO:0009986]; extracellular region [GO:0005576]; periplasmic space [GO:0042597] cell outer membrane [GO:0009279]; cell surface [GO:0009986]; extracellular region [GO:0005576]; periplasmic space [GO:0042597]; serine-type peptidase activity [GO:0008236]; cell adhesion involved in single-species biofilm formation [GO:0043709]; response to UV [GO:0009411] serine-type peptidase activity [GO:0008236] GO:0005576; GO:0008236; GO:0009279; GO:0009411; GO:0009986; GO:0042597; GO:0043709 SUBCELLULAR LOCATION: [Probable autotransporter YfaL]: Periplasm.; SUBCELLULAR LOCATION: [Probable secreted autotransporter protein YfaL]: Secreted. Cell surface.; SUBCELLULAR LOCATION: [Probable autotransporter YfaL translocator]: Cell outer membrane {ECO:0000269|PubMed:16522795}. +P76537 YFEY_ECOLI Uncharacterized protein YfeY yfeY b2432 JW2425 yfeY 20,898 +P76569 YFGD_ECOLI Uncharacterized protein YfgD yfgD b2495 JW2480 yfgD 13,399 cytosol [GO:0005829] cytosol [GO:0005829]; arsenate reductase (glutaredoxin) activity [GO:0008794] arsenate reductase (glutaredoxin) activity [GO:0008794] GO:0005829; GO:0008794 +P64476 YDIH_ECOLI Uncharacterized protein YdiH ydiH b1685 JW1675 ydiH 7,266 +P21361 YCIG_ECOLI Uncharacterized protein YciG yciG b1259 JW1251 yciG 6,002 bacterial-type flagellum-dependent swarming motility [GO:0071978] bacterial-type flagellum-dependent swarming motility [GO:0071978] GO:0071978 +P0AD12 YEEZ_ECOLI Protein YeeZ yeeZ b2016 JW1998 yeeZ 29,680 cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; catalytic activity [GO:0003824] ATP binding [GO:0005524]; catalytic activity [GO:0003824] GO:0003824; GO:0005524; GO:0005829 +P38394 YDAE_ECOLI Uncharacterized protein YdaE ydaE b4526 JW1346 ydaE 6,584 zinc ion binding [GO:0008270] zinc ion binding [GO:0008270] GO:0008270 +P33352 YEHP_ECOLI Uncharacterized protein YehP yehP b2121 JW5350 yehP 42,119 +Q46907 YGCQ_ECOLI Putative electron transfer flavoprotein subunit YgcQ ygcQ b2769 JW5440 ygcQ 30,308 electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660] electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660] GO:0009055; GO:0050660 +P0A9E9 YEIL_ECOLI Regulatory protein YeiL yeiL nsr b2163 JW2150 nsr yeiL 25,294 transcription, DNA-templated [GO:0006351] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; transcription, DNA-templated [GO:0006351] 4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872] GO:0003677; GO:0003700; GO:0005829; GO:0006351; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:11101674}. +P75704 YKIA_ECOLI Putative uncharacterized protein YkiA ykiA b0392 JW0383 ykiA 10,618 +P64485 YEAQ_ECOLI UPF0410 protein YeaQ yeaQ b1795 JW1784 yeaQ 8,671 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P46144 YEDJ_ECOLI Uncharacterized protein YedJ yedJ b1962 JW1945 yedJ 25,904 +P37676 YIAO_ECOLI 2,3-diketo-L-gulonate-binding periplasmic protein YiaO (2,3-DKG-binding protein) (Extracytoplasmic solute receptor protein YiaO) yiaO b3579 JW3551 yiaO 35,970 carbohydrate transport [GO:0008643]; cellular response to DNA damage stimulus [GO:0006974]; transmembrane transport [GO:0055085] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; carbohydrate binding [GO:0030246]; carbohydrate transport [GO:0008643]; cellular response to DNA damage stimulus [GO:0006974]; transmembrane transport [GO:0055085] carbohydrate binding [GO:0030246] GO:0006974; GO:0008643; GO:0030246; GO:0030288; GO:0055085 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:16385129}. +Q2M7R5 YIBT_ECOLI Uncharacterized protein YibT yibT b4554 JW3576 yibT 7,995 response to butan-1-ol [GO:1901422] response to butan-1-ol [GO:1901422] GO:1901422 +P31435 YICJ_ECOLI Inner membrane symporter YicJ yicJ b3657 JW5939 yicJ 50,948 carbohydrate transport [GO:0008643]; organic substance transport [GO:0071702]; sodium ion transport [GO:0006814] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; symporter activity [GO:0015293]; carbohydrate transport [GO:0008643]; organic substance transport [GO:0071702]; sodium ion transport [GO:0006814] symporter activity [GO:0015293] GO:0005886; GO:0005887; GO:0006814; GO:0008643; GO:0015293; GO:0071702 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P09163 YJAB_ECOLI Peptidyl-lysine N-acetyltransferase YjaB (EC 2.3.1.-) (KAT) yjaB b4012 JW3972 yjaB 16,447 internal peptidyl-lysine acetylation [GO:0018393] peptide-lysine-N-acetyltransferase activity [GO:0061733]; internal peptidyl-lysine acetylation [GO:0018393] peptide-lysine-N-acetyltransferase activity [GO:0061733] GO:0018393; GO:0061733 +P39357 YJHF_ECOLI Uncharacterized permease YjhF yjhF b4296 JW4258 yjhF 47,004 gluconate transmembrane transport [GO:0035429] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; gluconate transmembrane transporter activity [GO:0015128]; gluconate transmembrane transport [GO:0035429] gluconate transmembrane transporter activity [GO:0015128] GO:0005886; GO:0005887; GO:0015128; GO:0035429 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P56257 YKGL_ECOLI Uncharacterized protein YkgL ykgL b0295 JW5033 ykgL 8,767 +P39308 YJFZ_ECOLI Uncharacterized protein YjfZ yjfZ b4204 JW4162 yjfZ 29,739 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021] GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P45545 YHFS_ECOLI Uncharacterized protein YhfS yhfS b3376 JW3339 yhfS 38,599 biosynthetic process [GO:0009058] catalytic activity [GO:0003824]; pyridoxal phosphate binding [GO:0030170]; biosynthetic process [GO:0009058] catalytic activity [GO:0003824]; pyridoxal phosphate binding [GO:0030170] GO:0003824; GO:0009058; GO:0030170 +P0DPO3 YNAL_ECOLI Protein YnaL ynaL b4743 ynaL 6,428 +Q46799 XDHA_ECOLI Putative xanthine dehydrogenase molybdenum-binding subunit XdhA (EC 1.17.1.4) xdhA ygeS b2866 JW5462 ygeS xdhA 81,321 hypoxanthine catabolic process [GO:0009114]; purine ribonucleoside salvage [GO:0006166] metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; xanthine dehydrogenase activity [GO:0004854]; hypoxanthine catabolic process [GO:0009114]; purine ribonucleoside salvage [GO:0006166] metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; xanthine dehydrogenase activity [GO:0004854] GO:0004854; GO:0006166; GO:0009114; GO:0016491; GO:0046872 +P27829 WECC_ECOLI UDP-N-acetyl-D-mannosamine dehydrogenase (EC 1.1.1.336) (UDP-ManNAc 6-dehydrogenase) wecC rffD b3787 JW5599 rffD wecC 45,839 enterobacterial common antigen biosynthetic process [GO:0009246] cytosol [GO:0005829] cytosol [GO:0005829]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; UDP-N-acetyl-D-mannosamine dehydrogenase activity [GO:0089714]; enterobacterial common antigen biosynthetic process [GO:0009246] NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [GO:0016628]; UDP-N-acetyl-D-mannosamine dehydrogenase activity [GO:0089714] GO:0005829; GO:0009246; GO:0016628; GO:0051287; GO:0089714 +P27836 WECG_ECOLI UDP-N-acetyl-D-mannosaminuronic acid transferase (UDP-ManNAcA transferase) (EC 2.4.1.180) wecG rffM b3794 JW3770 rffM wecG 27,928 enterobacterial common antigen biosynthetic process [GO:0009246] lipopolysaccharide N-acetylmannosaminouronosyltransferase activity [GO:0047241]; transferase activity, transferring hexosyl groups [GO:0016758]; enterobacterial common antigen biosynthetic process [GO:0009246] lipopolysaccharide N-acetylmannosaminouronosyltransferase activity [GO:0047241]; transferase activity, transferring hexosyl groups [GO:0016758] GO:0009246; GO:0016758; GO:0047241 +P75838 YCAO_ECOLI Ribosomal protein S12 methylthiotransferase accessory factor YcaO ycaO b0905 JW0888 ycaO 65,652 peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid [GO:0018339] cytosol [GO:0005829] cytosol [GO:0005829]; ATP diphosphatase activity [GO:0047693]; magnesium ion binding [GO:0000287]; peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid [GO:0018339] ATP diphosphatase activity [GO:0047693]; magnesium ion binding [GO:0000287] GO:0000287; GO:0005829; GO:0018339; GO:0047693 +P77713 YAGH_ECOLI Putative beta-xylosidase (EC 3.2.1.37) (1,4-beta-D-xylan xylohydrolase) (Xylan 1,4-beta-xylosidase) yagH b0271 JW0264 yagH 60,825 xylan catabolic process [GO:0045493] xylan 1,4-beta-xylosidase activity [GO:0009044]; xylan catabolic process [GO:0045493] xylan 1,4-beta-xylosidase activity [GO:0009044] GO:0009044; GO:0045493 +P0A8B5 YBAB_ECOLI Nucleoid-associated protein YbaB ybaB b0471 JW0460 ybaB 12,015 response to radiation [GO:0009314] bacterial nucleoid [GO:0043590]; cytosol [GO:0005829] bacterial nucleoid [GO:0043590]; cytosol [GO:0005829]; DNA binding [GO:0003677]; response to radiation [GO:0009314] DNA binding [GO:0003677] GO:0003677; GO:0005829; GO:0009314; GO:0043590 SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-Rule:MF_00274}. +P0A8D3 YAII_ECOLI UPF0178 protein YaiI yaiI b0387 JW0378 yaiI 16,969 +P0A9T6 YBAQ_ECOLI Uncharacterized HTH-type transcriptional regulator YbaQ ybaQ b0483 JW0472 ybaQ 13,171 DNA binding [GO:0003677] DNA binding [GO:0003677] GO:0003677 +P62768 YAEH_ECOLI UPF0325 protein YaeH yaeH b0163 JW0159 yaeH 15,096 +P45564 YFEN_ECOLI Uncharacterized protein YfeN yfeN b2408 JW2399 yfeN 29,233 cell outer membrane [GO:0009279] cell outer membrane [GO:0009279] GO:0009279 +P77564 YDHW_ECOLI Uncharacterized protein YdhW ydhW b1672 JW1662 ydhW 24,421 +P42598 YGJQ_ECOLI Uncharacterized protein YgjQ ygjQ b3086 JW3057 ygjQ 25,480 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P76508 YFDL_ECOLI Putative uncharacterized protein YfdL yfdL b2355 JW5384 yfdL 18,252 +A5A607 YLCI_ECOLI Uncharacterized protein YlcI ylcI b4589 ylcI 7,521 +P76550 YFFS_ECOLI Uncharacterized protein YffS yffS b2450 yffS 29,751 cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677] DNA binding [GO:0003677] GO:0003677; GO:0005829 +P52132 YFJQ_ECOLI UPF0380 protein YfjQ yfjQ b2633 JW2614 yfjQ 31,255 +P52128 YFJM_ECOLI Uncharacterized protein YfjM yfjM b2629 JW2610 yfjM 9,967 +P69346 YEFM_ECOLI Antitoxin YefM yefM b2017 JW5835 yefM 9,308 negative regulation of transcription, DNA-templated [GO:0045892]; single-species biofilm formation [GO:0044010] sequence-specific DNA binding [GO:0043565]; toxic substance binding [GO:0015643]; negative regulation of transcription, DNA-templated [GO:0045892]; single-species biofilm formation [GO:0044010] sequence-specific DNA binding [GO:0043565]; toxic substance binding [GO:0015643] GO:0015643; GO:0043565; GO:0044010; GO:0045892 +P76100 YDCK_ECOLI Uncharacterized acetyltransferase YdcK (EC 2.3.1.-) ydcK b1428 JW1424 ydcK 35,849 transferase activity, transferring acyl groups [GO:0016746] transferase activity, transferring acyl groups [GO:0016746] GO:0016746 +P55138 YGCE_ECOLI Uncharacterized sugar kinase YgcE (EC 2.7.1.-) ygcE b2776 JW5444 ygcE 54,177 carbohydrate metabolic process [GO:0005975] kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; carbohydrate metabolic process [GO:0005975] kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773] GO:0005975; GO:0016301; GO:0016773 +P22787 YIFB_ECOLI Uncharacterized protein YifB yifB b3765 JW3738 yifB 55,146 ATP-dependent peptidase activity [GO:0004176] ATP-dependent peptidase activity [GO:0004176] GO:0004176 +P75976 YMFL_ECOLI Uncharacterized protein YmfL ymfL b1147 JW1133 ymfL 20,212 +P0ADR2 YGDD_ECOLI UPF0382 inner membrane protein YgdD ygdD b2807 JW2778 ygdD 14,333 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76123 YDDK_ECOLI Leucine-rich repeat domain-containing protein YddK yddK b1471 JW1467 yddK 36,241 +P76210 YDJO_ECOLI Uncharacterized protein YdjO ydjO b1730 JW1719 ydjO 30,160 +P0ACM9 YIHL_ECOLI Uncharacterized HTH-type transcriptional regulator YihL yihL b3872 JW3843 yihL 26,939 negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0045892 +P0ADJ3 YHJR_ECOLI Protein YhjR yhjR b3535 JW3503 yhjR 7,018 bacterial cellulose biosynthetic process [GO:0090540] bacterial cellulose biosynthetic process [GO:0090540] GO:0090540 +P37197 YHJA_ECOLI Probable cytochrome c peroxidase (EC 1.11.1.5) yhjA b3518 JW3486 yhjA 51,571 anaerobic electron transport chain [GO:0019645]; hydrogen peroxide metabolic process [GO:0042743]; response to hydrogen peroxide [GO:0042542] cytochrome-c peroxidase activity [GO:0004130]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; anaerobic electron transport chain [GO:0019645]; hydrogen peroxide metabolic process [GO:0042743]; response to hydrogen peroxide [GO:0042542] cytochrome-c peroxidase activity [GO:0004130]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872] GO:0004130; GO:0009055; GO:0019645; GO:0020037; GO:0042542; GO:0042743; GO:0046872 +P39336 YJGL_ECOLI Uncharacterized protein YjgL yjgL b4253 JW5757 yjgL 69,578 +P0ADI9 YHHN_ECOLI Uncharacterized membrane protein YhhN yhhN b3468 JW3433 yhhN 23,791 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; alkenylglycerophosphocholine hydrolase activity [GO:0047408]; alkenylglycerophosphoethanolamine hydrolase activity [GO:0047409] alkenylglycerophosphocholine hydrolase activity [GO:0047408]; alkenylglycerophosphoethanolamine hydrolase activity [GO:0047409] GO:0005886; GO:0016021; GO:0047408; GO:0047409 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P58037 YRHD_ECOLI Protein YrhD yrhD b4612 b3445.1 yrhD 6,027 +P39187 YTFJ_ECOLI Uncharacterized protein YtfJ ytfJ b4216 JW4175 ytfJ 20,421 periplasmic space [GO:0042597] periplasmic space [GO:0042597] GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P0AEC0 YOAE_ECOLI UPF0053 inner membrane protein YoaE yoaE b1816 JW1805 yoaE 56,528 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; flavin adenine dinucleotide binding [GO:0050660] flavin adenine dinucleotide binding [GO:0050660] GO:0005886; GO:0016021; GO:0050660 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P67601 YOBD_ECOLI UPF0266 membrane protein YobD yobD b1820 JW1809 yobD 17,615 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0DSF8 YODE_ECOLI Protein YodE yodE b4780 yodE 5,068 +P77374 YNFE_ECOLI Putative dimethyl sulfoxide reductase chain YnfE (DMSO reductase) (EC 1.8.99.-) ynfE b1587 JW1579 ynfE 89,780 anaerobic respiration [GO:0009061] outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; 4 iron, 4 sulfur cluster binding [GO:0051539]; dimethyl sulfoxide reductase activity [GO:0009389]; electron transfer activity [GO:0009055]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; selenate reductase activity [GO:0033797]; anaerobic respiration [GO:0009061] 4 iron, 4 sulfur cluster binding [GO:0051539]; dimethyl sulfoxide reductase activity [GO:0009389]; electron transfer activity [GO:0009055]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; selenate reductase activity [GO:0033797] GO:0005886; GO:0009055; GO:0009061; GO:0009389; GO:0030151; GO:0030288; GO:0033797; GO:0043546; GO:0051539 SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. +P77136 YQEK_ECOLI Uncharacterized protein YqeK yqeK b2849 JW2817 yqeK 16,272 +P77616 YQIH_ECOLI Uncharacterized fimbrial chaperone YqiH yqiH b3047 JW5508 yqiH 28,492 cellular response to DNA damage stimulus [GO:0006974]; cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; cell wall organization [GO:0071555]; cellular response to DNA damage stimulus [GO:0006974]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] GO:0006974; GO:0030288; GO:0043711; GO:0061077; GO:0071555 SUBCELLULAR LOCATION: Periplasm {ECO:0000250}. +P77658 YNAA_ECOLI Protein YnaA ynaA tmpR b1368 JW1361 tmpR ynaA 37,060 +P0ADS2 ZAPA_ECOLI Cell division protein ZapA (Z ring-associated protein ZapA) zapA ygfE b2910 JW2878 ygfE zapA 12,594 cell division [GO:0051301]; division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093]; septin ring assembly [GO:0000921] cell division site [GO:0032153]; cell septum [GO:0030428]; cytosol [GO:0005829]; plasma membrane [GO:0005886] cell division site [GO:0032153]; cell septum [GO:0030428]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; cell division [GO:0051301]; division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093]; septin ring assembly [GO:0000921] identical protein binding [GO:0042802] GO:0000917; GO:0000921; GO:0005829; GO:0005886; GO:0030428; GO:0032153; GO:0042802; GO:0043093; GO:0051301 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12368265}. Note=Localizes at mid-cell. +P76329 MPGP_ECOLI Mannosyl-3-phosphoglycerate phosphatase (MPGP) (EC 3.1.3.70) yedP b1955 JW1938 yedP 30,439 mannosylglycerate biosynthetic process [GO:0051479] cytosol [GO:0005829] cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; mannosyl-3-phosphoglycerate phosphatase activity [GO:0050531]; phosphatase activity [GO:0016791]; mannosylglycerate biosynthetic process [GO:0051479] magnesium ion binding [GO:0000287]; mannosyl-3-phosphoglycerate phosphatase activity [GO:0050531]; phosphatase activity [GO:0016791] GO:0000287; GO:0005829; GO:0016791; GO:0050531; GO:0051479 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00617}. +P75785 OPGE_ECOLI Phosphoethanolamine transferase OpgE (EC 2.7.-.-) opgE ybiP b0815 JW0800 ybiP opgE 59,706 lipopolysaccharide core region biosynthetic process [GO:0009244] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; phosphotransferase activity, phosphate group as acceptor [GO:0016776]; sulfuric ester hydrolase activity [GO:0008484]; lipopolysaccharide core region biosynthetic process [GO:0009244] phosphotransferase activity, phosphate group as acceptor [GO:0016776]; sulfuric ester hydrolase activity [GO:0008484] GO:0005886; GO:0008484; GO:0009244; GO:0016021; GO:0016776 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P05041 PABB_ECOLI Aminodeoxychorismate synthase component 1 (ADC synthase) (ADCS) (EC 2.6.1.85) (4-amino-4-deoxychorismate synthase component 1) pabB b1812 JW1801 pabB 50,970 folic acid biosynthetic process [GO:0046656]; para-aminobenzoic acid biosynthetic process [GO:0008153]; tetrahydrofolate biosynthetic process [GO:0046654] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 4-amino-4-deoxychorismate synthase activity [GO:0046820]; magnesium ion binding [GO:0000287]; folic acid biosynthetic process [GO:0046656]; para-aminobenzoic acid biosynthetic process [GO:0008153]; tetrahydrofolate biosynthetic process [GO:0046654] 4-amino-4-deoxychorismate synthase activity [GO:0046820]; magnesium ion binding [GO:0000287] GO:0000287; GO:0005737; GO:0008153; GO:0046654; GO:0046656; GO:0046820 +P25906 PDXI_ECOLI Pyridoxine 4-dehydrogenase (EC 1.1.1.65) pdxI ydbC b1406 JW1403 ydbC pdxI 30,706 cytosol [GO:0005829] cytosol [GO:0005829]; D-threo-aldose 1-dehydrogenase activity [GO:0047834]; pyridoxine:NADP 4-dehydrogenase activity [GO:0050236] D-threo-aldose 1-dehydrogenase activity [GO:0047834]; pyridoxine:NADP 4-dehydrogenase activity [GO:0050236] GO:0005829; GO:0047834; GO:0050236 +P16678 PHNK_ECOLI Putative phosphonates utilization ATP-binding protein PhnK phnK b4097 JW5727 phnK 27,831 organic phosphonate catabolic process [GO:0019700] carbon phosphorus lyase complex [GO:1904176] carbon phosphorus lyase complex [GO:1904176]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; organic phosphonate catabolic process [GO:0019700] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0019700; GO:0042626; GO:1904176 +P55798 PRP1_ECOLI Serine/threonine-protein phosphatase 1 (EC 3.1.3.16) pphA prpA yebX b1838 JW1827 prpA yebX pphA 25,274 response to temperature stimulus [GO:0009266] metal ion binding [GO:0046872]; protein serine phosphatase activity [GO:0106306]; protein threonine phosphatase activity [GO:0106307]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; response to temperature stimulus [GO:0009266] metal ion binding [GO:0046872]; protein serine phosphatase activity [GO:0106306]; protein threonine phosphatase activity [GO:0106307]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138] GO:0008138; GO:0009266; GO:0046872; GO:0106306; GO:0106307 +P0AFM4 PSIF_ECOLI Phosphate starvation-inducible protein PsiF psiF b0384 JW5054 psiF 11,687 +P0DMC9 RCSA_ECOLI Transcriptional regulatory protein RcsA (Colanic acid capsular biosynthesis activation protein A) rcsA b1951 JW1935 rcsA 23,516 regulation of transcription, DNA-templated [GO:0006355]; response to stimulus [GO:0050896]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; regulation of transcription, DNA-templated [GO:0006355]; response to stimulus [GO:0050896]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677] GO:0003677; GO:0006351; GO:0006355; GO:0050896 +Q47152 RAYT_ECOLI REP-associated tyrosine transposase rayT TnpAREP yafM b0228 JW0218 TnpAREP yafM rayT 20,042 DNA recombination [GO:0006310]; transposition, DNA-mediated [GO:0006313] bubble DNA binding [GO:0000405]; DNA binding [GO:0003677]; DNA hairpin binding [GO:0032448]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; transposase activity [GO:0004803]; DNA recombination [GO:0006310]; transposition, DNA-mediated [GO:0006313] bubble DNA binding [GO:0000405]; DNA binding [GO:0003677]; DNA hairpin binding [GO:0032448]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; transposase activity [GO:0004803] GO:0000014; GO:0000405; GO:0003677; GO:0003697; GO:0004803; GO:0006310; GO:0006313; GO:0032448; GO:0043565 +P76470 RHMT_ECOLI Inner membrane transport protein RhmT rhmT yfaV b2246 JW2240 yfaV rhmT 46,294 integral component of membrane [GO:0016021]; intrinsic component of membrane [GO:0031224]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; intrinsic component of membrane [GO:0031224]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857; GO:0031224 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P25888 RHLE_ECOLI ATP-dependent RNA helicase RhlE (EC 3.6.4.13) rhlE b0797 JW0781 rhlE 49,989 response to heat [GO:0009408]; ribosome assembly [GO:0042255] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; response to heat [GO:0009408]; ribosome assembly [GO:0042255] ATP binding [GO:0005524]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] GO:0003723; GO:0003724; GO:0005524; GO:0005829; GO:0009408; GO:0042255 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00968, ECO:0000269|PubMed:18083833}. Note=Ribosome-associated. Can either bind to the intact 70S ribosome or to individual ribosomal subunits. +P27128 RFAI_ECOLI Lipopolysaccharide 1,3-galactosyltransferase (EC 2.4.1.44) (Lipopolysaccharide 3-alpha-galactosyltransferase) rfaI waaI b3627 JW3602 waaI rfaI 39,423 lipopolysaccharide core region biosynthetic process [GO:0009244] lipopolysaccharide 3-alpha-galactosyltransferase activity [GO:0008918]; lipopolysaccharide glucosyltransferase II activity [GO:0047270]; metal ion binding [GO:0046872]; lipopolysaccharide core region biosynthetic process [GO:0009244] lipopolysaccharide 3-alpha-galactosyltransferase activity [GO:0008918]; lipopolysaccharide glucosyltransferase II activity [GO:0047270]; metal ion binding [GO:0046872] GO:0008918; GO:0009244; GO:0046872; GO:0047270 +P25741 RFAP_ECOLI Lipopolysaccharide core heptose(I) kinase RfaP (EC 2.7.1.-) rfaP waaP b3630 JW3605 waaP rfaP 30,872 carbohydrate phosphorylation [GO:0046835]; lipopolysaccharide core region biosynthetic process [GO:0009244] ATP binding [GO:0005524]; kinase activity [GO:0016301]; carbohydrate phosphorylation [GO:0046835]; lipopolysaccharide core region biosynthetic process [GO:0009244] ATP binding [GO:0005524]; kinase activity [GO:0016301] GO:0005524; GO:0009244; GO:0016301; GO:0046835 +P24211 RHSE_ECOLI Putative protein RhsE rhsE b1456 JW1451 rhsE 77,142 +P52094 HISQ_ECOLI Histidine transport system permease protein HisQ hisQ b2308 JW2305 hisQ 24,649 L-histidine import across plasma membrane [GO:1903810]; L-histidine transmembrane transport [GO:0089709] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; high-affinity L-histidine transmembrane transporter activity [GO:0005291]; L-histidine import across plasma membrane [GO:1903810]; L-histidine transmembrane transport [GO:0089709] high-affinity L-histidine transmembrane transporter activity [GO:0005291] GO:0005291; GO:0005886; GO:0043190; GO:0089709; GO:1903810 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:15919996}. +P25746 HFLD_ECOLI High frequency lysogenization protein HflD hflD ycfC b1132 JW5165 ycfC hflD 22,948 response to heat [GO:0009408] cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; plasma membrane [GO:0005886]; response to heat [GO:0009408] GO:0005737; GO:0005886; GO:0009408; GO:0031234 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11278968}. Cell inner membrane {ECO:0000269|PubMed:11278968}; Peripheral membrane protein {ECO:0000269|PubMed:11278968}; Cytoplasmic side {ECO:0000269|PubMed:11278968}. +Q47153 LFHA_ECOLI Putative truncated flagellar export/assembly protein LfhA lfhA fhiA b0229 JW5811 fhiA lfhA 63,153 bacterial-type flagellum assembly [GO:0044780]; protein secretion [GO:0009306] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; bacterial-type flagellum assembly [GO:0044780]; protein secretion [GO:0009306] GO:0005886; GO:0009306; GO:0016021; GO:0044780 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P0ACV4 LAPA_ECOLI Lipopolysaccharide assembly protein A lapA yciS b1279 JW1271 yciS lapA 11,351 lipopolysaccharide metabolic process [GO:0008653] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; lipopolysaccharide metabolic process [GO:0008653] GO:0005886; GO:0005887; GO:0008653 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01948, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:24722986}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01948}. Note=Copurifies with LptE/LptD, LptBFGC, LptA, DnaK/DnaJ and LPS. {ECO:0000269|PubMed:24722986}. +P0AF03 MOG_ECOLI Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) mog chlG mogA yaaG b0009 JW0008 chlG mogA yaaG mog 21,222 molybdopterin cofactor biosynthetic process [GO:0032324]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; molybdopterin adenylyltransferase activity [GO:0061598]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdopterin cofactor biosynthetic process [GO:0032324] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; molybdopterin adenylyltransferase activity [GO:0061598] GO:0005524; GO:0005829; GO:0006777; GO:0032324; GO:0042802; GO:0061598 +P75949 NAGZ_ECOLI Beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (N-acetyl-beta-glucosaminidase) nagZ ycfO b1107 JW1093 ycfO nagZ 37,595 carbohydrate metabolic process [GO:0005975]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan turnover [GO:0009254]; regulation of cell shape [GO:0008360] cytosol [GO:0005829] cytosol [GO:0005829]; beta-N-acetylhexosaminidase activity [GO:0004563]; N-acetyl-beta-D-galactosaminidase activity [GO:0102148]; carbohydrate metabolic process [GO:0005975]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan turnover [GO:0009254]; regulation of cell shape [GO:0008360] beta-N-acetylhexosaminidase activity [GO:0004563]; N-acetyl-beta-D-galactosaminidase activity [GO:0102148] GO:0004563; GO:0005829; GO:0005975; GO:0007049; GO:0008360; GO:0009252; GO:0009254; GO:0051301; GO:0071555; GO:0102148 SUBCELLULAR LOCATION: Cytoplasm. +P42615 MZRA_ECOLI Modulator protein MzrA mzrA ecfM yqjB b3096 JW3067 ecfM yqjB mzrA 14,172 regulation of protein kinase activity [GO:0045859] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; protein kinase binding [GO:0019901]; regulation of protein kinase activity [GO:0045859] protein kinase binding [GO:0019901] GO:0005887; GO:0019901; GO:0045859 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00904, ECO:0000269|PubMed:19432797, ECO:0000269|PubMed:20889743}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00904, ECO:0000269|PubMed:19432797, ECO:0000269|PubMed:20889743}. +P77489 PAOC_ECOLI Aldehyde oxidoreductase molybdenum-binding subunit PaoC (EC 1.2.99.6) paoC yagR b0284 JW0278 yagR paoC 78,088 cellular response to DNA damage stimulus [GO:0006974] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; carboxylate reductase activity [GO:0047770]; molybdenum ion binding [GO:0030151]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on the aldehyde or oxo group of donors [GO:0016903]; cellular response to DNA damage stimulus [GO:0006974] carboxylate reductase activity [GO:0047770]; molybdenum ion binding [GO:0030151]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on the aldehyde or oxo group of donors [GO:0016903] GO:0006974; GO:0016491; GO:0016903; GO:0030151; GO:0042597; GO:0047770 SUBCELLULAR LOCATION: Periplasm {ECO:0000305|PubMed:19368556}. +P23830 PSS_ECOLI CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) (Phosphatidylserine synthase) pssA pss b2585 JW2569 pss pssA 52,802 cardiolipin biosynthetic process [GO:0032049]; phospholipid biosynthetic process [GO:0008654] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [GO:0008444]; CDP-diacylglycerol-serine O-phosphatidyltransferase activity [GO:0003882]; phospholipid binding [GO:0005543]; cardiolipin biosynthetic process [GO:0032049]; phospholipid biosynthetic process [GO:0008654] CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [GO:0008444]; CDP-diacylglycerol-serine O-phosphatidyltransferase activity [GO:0003882]; phospholipid binding [GO:0005543] GO:0003882; GO:0005543; GO:0005737; GO:0005829; GO:0005886; GO:0008444; GO:0008654; GO:0032049 SUBCELLULAR LOCATION: Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. +P27249 GLND_ECOLI Bifunctional uridylyltransferase/uridylyl-removing enzyme (UTase/UR) (Bifunctional [protein-PII] modification enzyme) (Bifunctional nitrogen sensor protein) [Includes: [Protein-PII] uridylyltransferase (PII uridylyltransferase) (UTase) (EC 2.7.7.59); [Protein-PII]-UMP uridylyl-removing enzyme (UR) (EC 3.1.4.-)] glnD b0167 JW0162 glnD 102,390 cellular protein modification process [GO:0006464]; regulation of nitrogen utilization [GO:0006808] [protein-PII] uridylyltransferase activity [GO:0008773]; phosphoric diester hydrolase activity [GO:0008081]; cellular protein modification process [GO:0006464]; regulation of nitrogen utilization [GO:0006808] [protein-PII] uridylyltransferase activity [GO:0008773]; phosphoric diester hydrolase activity [GO:0008081] GO:0006464; GO:0006808; GO:0008081; GO:0008773 +P77432 LSRK_ECOLI Autoinducer-2 kinase (AI-2 kinase) (EC 2.7.1.189) lsrK ydeV b1511 JW1504 ydeV lsrK 57,545 carbohydrate metabolic process [GO:0005975]; quorum sensing [GO:0009372]; single-species biofilm formation [GO:0044010] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; autoinducer-2 kinase activity [GO:0071518]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; carbohydrate metabolic process [GO:0005975]; quorum sensing [GO:0009372]; single-species biofilm formation [GO:0044010] autoinducer-2 kinase activity [GO:0071518]; phosphotransferase activity, alcohol group as acceptor [GO:0016773] GO:0005737; GO:0005975; GO:0009372; GO:0016773; GO:0044010; GO:0071518 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02053}. +P0A6W3 MRAY_ECOLI Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) (UDP-MurNAc-pentapeptide phosphotransferase) mraY murX b0087 JW0085 murX mraY 39,875 cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall macromolecule biosynthetic process [GO:0044038]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; metal ion binding [GO:0046872]; phospho-N-acetylmuramoyl-pentapeptide-transferase activity [GO:0008963]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity [GO:0051992]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall macromolecule biosynthetic process [GO:0044038]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] metal ion binding [GO:0046872]; phospho-N-acetylmuramoyl-pentapeptide-transferase activity [GO:0008963]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity [GO:0051992] GO:0005887; GO:0007049; GO:0008360; GO:0008963; GO:0009252; GO:0016020; GO:0016780; GO:0044038; GO:0046872; GO:0051301; GO:0051992; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00038, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00038, ECO:0000269|PubMed:15919996}. +P69432 PGAD_ECOLI Biofilm PGA synthesis protein PgaD pgaD ycdP b1021 JW1006 ycdP pgaD 16,082 cell adhesion involved in biofilm formation [GO:0043708]; cell adhesion involved in single-species biofilm formation [GO:0043709] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cell adhesion involved in biofilm formation [GO:0043708]; cell adhesion involved in single-species biofilm formation [GO:0043709] GO:0005886; GO:0016021; GO:0043708; GO:0043709 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P40191 PDXK_ECOLI Pyridoxine/pyridoxal/pyridoxamine kinase (PN/PL/PM kinase) (EC 2.7.1.35) (B6-vitamer kinase) (Pyridoxal kinase 1) (PL kinase 1) pdxK yfeI b2418 JW2411 yfeI pdxK 30,847 pyridoxal 5'-phosphate salvage [GO:0009443]; pyridoxine biosynthetic process [GO:0008615] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; hydroxymethylpyrimidine kinase activity [GO:0008902]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; potassium ion binding [GO:0030955]; pyridoxal kinase activity [GO:0008478]; pyridoxal phosphate binding [GO:0030170]; zinc ion binding [GO:0008270]; pyridoxal 5'-phosphate salvage [GO:0009443]; pyridoxine biosynthetic process [GO:0008615] ATP binding [GO:0005524]; hydroxymethylpyrimidine kinase activity [GO:0008902]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; potassium ion binding [GO:0030955]; pyridoxal kinase activity [GO:0008478]; pyridoxal phosphate binding [GO:0030170]; zinc ion binding [GO:0008270] GO:0000287; GO:0005524; GO:0005829; GO:0008270; GO:0008478; GO:0008615; GO:0008902; GO:0009443; GO:0030170; GO:0030955; GO:0046872 +P37095 PEPB_ECOLI Peptidase B (EC 3.4.11.23) (Aminopeptidase B) pepB yfhI b2523 JW2507 yfhI pepB 46,180 peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] cytosol [GO:0005829] cytosol [GO:0005829]; aminopeptidase activity [GO:0004177]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] aminopeptidase activity [GO:0004177]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0004177; GO:0005829; GO:0006508; GO:0030145; GO:0042802; GO:0043171; GO:0070006 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00504}. +P69811 PTFAH_ECOLI Multiphosphoryl transfer protein (MTP) (Diphosphoryl transfer protein) (DTP) (Phosphotransferase FPr protein) (Pseudo-HPr) [Includes: Phosphocarrier protein HPr (Protein H); PTS system fructose-specific EIIA component (EIIA-Fru) (EIII-Fru) (Fructose-specific phosphotransferase enzyme IIA component)] fruB fpr fruF b2169 JW2156 fpr fruF fruB 39,648 fructose import [GO:0032445]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737]; extrinsic component of plasma membrane [GO:0019897]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; extrinsic component of plasma membrane [GO:0019897]; plasma membrane [GO:0005886]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity [GO:0022877]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; fructose import [GO:0032445]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity [GO:0022877]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005737; GO:0005886; GO:0009401; GO:0016301; GO:0019897; GO:0022877; GO:0032445; GO:0090563 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A7D1 PTH_ECOLI Peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29) pth b1204 JW1195 pth 21,082 protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; translation [GO:0006412] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; aminoacyl-tRNA hydrolase activity [GO:0004045]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; translation [GO:0006412] aminoacyl-tRNA hydrolase activity [GO:0004045] GO:0004045; GO:0005737; GO:0006412; GO:0006515 SUBCELLULAR LOCATION: Cytoplasm. +P23871 HEMH_ECOLI Ferrochelatase (EC 4.99.1.1) (Heme synthase) (Protoheme ferro-lyase) hemH popA visA b0475 JW0464 popA visA hemH 35,884 heme biosynthetic process [GO:0006783]; protoporphyrinogen IX metabolic process [GO:0046501]; response to light stimulus [GO:0009416] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ferrochelatase activity [GO:0004325]; metal ion binding [GO:0046872]; heme biosynthetic process [GO:0006783]; protoporphyrinogen IX metabolic process [GO:0046501]; response to light stimulus [GO:0009416] ferrochelatase activity [GO:0004325]; metal ion binding [GO:0046872] GO:0004325; GO:0005737; GO:0006783; GO:0009416; GO:0046501; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00323}. +P0AET8 HDHA_ECOLI 7alpha-hydroxysteroid dehydrogenase (7alpha-HSDH) (EC 1.1.1.159) (NAD-dependent 7alpha-hydroxysteroid dehydrogenase) hdhA hsdH b1619 JW1611 hsdH hdhA 26,779 bile acid catabolic process [GO:0030573]; lipid catabolic process [GO:0016042] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity [GO:0106281]; cholate 7-alpha-dehydrogenase activity [GO:0008709]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; bile acid catabolic process [GO:0030573]; lipid catabolic process [GO:0016042] chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity [GO:0106281]; cholate 7-alpha-dehydrogenase activity [GO:0008709]; identical protein binding [GO:0042802]; NAD binding [GO:0051287] GO:0005829; GO:0008709; GO:0016042; GO:0030573; GO:0032991; GO:0042802; GO:0051287; GO:0106281 +P45753 HOFM_ECOLI DNA utilization protein HofM hofM yrfD b3395 JW5693 yrfD hofM 29,000 carbon utilization [GO:0015976]; DNA catabolic process [GO:0006308] carbon utilization [GO:0015976]; DNA catabolic process [GO:0006308] GO:0006308; GO:0015976 +P00893 ILVI_ECOLI Acetolactate synthase isozyme 3 large subunit (EC 2.2.1.6) (AHAS-III) (ALS-III) (Acetohydroxy-acid synthase III large subunit) ilvI b0077 JW0076 ilvI 62,984 isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] acetolactate synthase complex [GO:0005948]; cytosol [GO:0005829] acetolactate synthase complex [GO:0005948]; cytosol [GO:0005829]; acetolactate synthase activity [GO:0003984]; flavin adenine dinucleotide binding [GO:0050660]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976]; isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] acetolactate synthase activity [GO:0003984]; flavin adenine dinucleotide binding [GO:0050660]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976] GO:0000287; GO:0003984; GO:0005829; GO:0005948; GO:0009097; GO:0009099; GO:0030976; GO:0050660 +P39380 KPTA_ECOLI RNA 2'-phosphotransferase (EC 2.7.1.-) kptA yjiI b4331 JW5784 yjiI kptA 20,530 tRNA processing [GO:0008033]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388] NAD+ ADP-ribosyltransferase activity [GO:0003950]; transferase activity, transferring phosphorus-containing groups [GO:0016772]; tRNA 2'-phosphotransferase activity [GO:0000215]; tRNA processing [GO:0008033]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388] NAD+ ADP-ribosyltransferase activity [GO:0003950]; transferase activity, transferring phosphorus-containing groups [GO:0016772]; tRNA 2'-phosphotransferase activity [GO:0000215] GO:0000215; GO:0003950; GO:0006388; GO:0008033; GO:0016772 +P23883 PUUC_ECOLI NADP/NAD-dependent aldehyde dehydrogenase PuuC (ALDH) (EC 1.2.1.5) (3-hydroxypropionaldehyde dehydrogenase) (Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase) (Gamma-Glu-gamma-aminobutyraldehyde dehydrogenase) puuC aldH b1300 JW1293 aldH puuC 53,419 putrescine catabolic process [GO:0009447] aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase (NADP+) activity [GO:0033721]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030]; putrescine catabolic process [GO:0009447] aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase (NADP+) activity [GO:0033721]; aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030] GO:0004029; GO:0004030; GO:0009447; GO:0033721 +P22564 RIHC_ECOLI Non-specific ribonucleoside hydrolase RihC (EC 3.2.-.-) (Purine/pyrimidine ribonucleoside hydrolase) rihC yaaF b0030 JW0028 yaaF rihC 32,561 cellular response to DNA damage stimulus [GO:0006974]; purine nucleobase metabolic process [GO:0006144]; purine nucleoside catabolic process [GO:0006152]; pyrimidine nucleobase metabolic process [GO:0006206]; ribonucleoside catabolic process [GO:0042454] cytosol [GO:0005829] cytosol [GO:0005829]; adenosine nucleosidase activity [GO:0047622]; inosine nucleosidase activity [GO:0047724]; purine nucleosidase activity [GO:0008477]; ribosylpyrimidine nucleosidase activity [GO:0050263]; uridine nucleosidase activity [GO:0045437]; cellular response to DNA damage stimulus [GO:0006974]; purine nucleobase metabolic process [GO:0006144]; purine nucleoside catabolic process [GO:0006152]; pyrimidine nucleobase metabolic process [GO:0006206]; ribonucleoside catabolic process [GO:0042454] adenosine nucleosidase activity [GO:0047622]; inosine nucleosidase activity [GO:0047724]; purine nucleosidase activity [GO:0008477]; ribosylpyrimidine nucleosidase activity [GO:0050263]; uridine nucleosidase activity [GO:0045437] GO:0005829; GO:0006144; GO:0006152; GO:0006206; GO:0006974; GO:0008477; GO:0042454; GO:0045437; GO:0047622; GO:0047724; GO:0050263 +P76577 PBPC_ECOLI Penicillin-binding protein 1C (PBP-1c) (PBP1c) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase); Transpeptidase-like module] pbpC yfgN b2519 JW2503 yfgN pbpC 85,067 cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; positive regulation of cell division [GO:0051781]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; carboxypeptidase activity [GO:0004180]; drug binding [GO:0008144]; penicillin binding [GO:0008658]; peptidoglycan glycosyltransferase activity [GO:0008955]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; positive regulation of cell division [GO:0051781]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] carboxypeptidase activity [GO:0004180]; drug binding [GO:0008144]; penicillin binding [GO:0008658]; peptidoglycan glycosyltransferase activity [GO:0008955] GO:0004180; GO:0005886; GO:0008144; GO:0008360; GO:0008658; GO:0008955; GO:0009252; GO:0016021; GO:0046677; GO:0051781; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:10542235}; Single-pass type II membrane protein {ECO:0000250}. +P28305 PABC_ECOLI Aminodeoxychorismate lyase (EC 4.1.3.38) (4-amino-4-deoxychorismate lyase) (ADC lyase) (ADCL) pabC b1096 JW1082 pabC 29,715 carboxylic acid metabolic process [GO:0019752]; folic acid biosynthetic process [GO:0046656]; para-aminobenzoic acid biosynthetic process [GO:0008153]; tetrahydrofolate biosynthetic process [GO:0046654] cytosol [GO:0005829] cytosol [GO:0005829]; 4-amino-4-deoxychorismate lyase activity [GO:0008696]; pyridoxal phosphate binding [GO:0030170]; carboxylic acid metabolic process [GO:0019752]; folic acid biosynthetic process [GO:0046656]; para-aminobenzoic acid biosynthetic process [GO:0008153]; tetrahydrofolate biosynthetic process [GO:0046654] 4-amino-4-deoxychorismate lyase activity [GO:0008696]; pyridoxal phosphate binding [GO:0030170] GO:0005829; GO:0008153; GO:0008696; GO:0019752; GO:0030170; GO:0046654; GO:0046656 +P00914 PHR_ECOLI Deoxyribodipyrimidine photo-lyase (EC 4.1.99.3) (DNA photolyase) (Photoreactivating enzyme) phrB phr b0708 JW0698 phr phrB 53,667 photoreactive repair [GO:0000719]; phototransduction, visible light [GO:0007603]; protein-chromophore linkage [GO:0018298]; response to light stimulus [GO:0009416] damaged DNA binding [GO:0003684]; deoxyribodipyrimidine photo-lyase activity [GO:0003904]; DNA binding [GO:0003677]; FAD binding [GO:0071949]; photoreactive repair [GO:0000719]; phototransduction, visible light [GO:0007603]; protein-chromophore linkage [GO:0018298]; response to light stimulus [GO:0009416] damaged DNA binding [GO:0003684]; deoxyribodipyrimidine photo-lyase activity [GO:0003904]; DNA binding [GO:0003677]; FAD binding [GO:0071949] GO:0000719; GO:0003677; GO:0003684; GO:0003904; GO:0007603; GO:0009416; GO:0018298; GO:0071949 +P02932 PHOE_ECOLI Outer membrane porin PhoE (Outer membrane pore protein E) phoE ompE b0241 JW0231 ompE phoE 38,922 ion transmembrane transport [GO:0034220] cell outer membrane [GO:0009279]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; pore complex [GO:0046930]; porin activity [GO:0015288]; ion transmembrane transport [GO:0034220] porin activity [GO:0015288] GO:0009279; GO:0015288; GO:0034220; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:2464593}; Multi-pass membrane protein. +P16919 RHSD_ECOLI Protein RhsD rhsD b0497 JW0486 rhsD 159,725 cellular response to sulfur starvation [GO:0010438] cellular response to sulfur starvation [GO:0010438] GO:0010438 +P75794 PFLE_ECOLI Putative pyruvate formate-lyase 3-activating enzyme (EC 1.97.1.4) (Formate-C-acetyltransferase-activating enzyme 3) (PFL-activating enzyme 3) ybiY b0824 JW0808 ybiY 33,038 cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 4 iron, 4 sulfur cluster binding [GO:0051539]; [formate-C-acetyltransferase]-activating enzyme activity [GO:0043365]; metal ion binding [GO:0046872] [formate-C-acetyltransferase]-activating enzyme activity [GO:0043365]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0005737; GO:0043365; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P77579 PTFC1_ECOLI Fructose-like permease IIC component 1 (PTS system fructose-like EIIC component 1) fryC ypdG b2386 JW2383 ypdG fryC 43,966 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005886; GO:0008982; GO:0009401; GO:0016021; GO:0090563 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P69826 PTMCB_ECOLI PTS system mannitol-specific cryptic EIICB component (EIICB-Mtl) (EII-Mtl) [Includes: Mannitol permease IIC component (PTS system mannitol-specific EIIC component); Mannitol-specific phosphotransferase enzyme IIB component (EC 2.7.1.197) (PTS system mannitol-specific EIIB component)] cmtA b2933 JW2900 cmtA 48,971 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity [GO:0022872]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity [GO:0022872] GO:0005886; GO:0009401; GO:0016021; GO:0016301; GO:0022872 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00427, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00427, ECO:0000269|PubMed:15919996}. +P42909 PTPB1_ECOLI N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 1 (EC 2.7.1.-) (EIIB-Aga) (PTS system N-acetylgalactosamine-specific EIIB component 1) agaB yraD b3138 JW3107 yraD agaB 17,622 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982] GO:0005737; GO:0008982; GO:0009401; GO:0016301 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A7F9 QUEA_ECOLI S-adenosylmethionine:tRNA ribosyltransferase-isomerase (EC 2.4.99.17) (Queuosine biosynthesis protein QueA) queA b0405 JW0395 queA 39,431 queuosine biosynthetic process [GO:0008616]; response to radiation [GO:0009314]; tRNA wobble guanine modification [GO:0002099] cytosol [GO:0005829] cytosol [GO:0005829]; S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity [GO:0051075]; queuosine biosynthetic process [GO:0008616]; response to radiation [GO:0009314]; tRNA wobble guanine modification [GO:0002099] S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity [GO:0051075] GO:0002099; GO:0005829; GO:0008616; GO:0009314; GO:0051075 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P52076 QSEB_ECOLI Transcriptional regulatory protein QseB qseB ygiX b3025 JW2993 ygiX qseB 24,678 response to metal ion [GO:0010038]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; response to metal ion [GO:0010038]; transcription, DNA-templated [GO:0006351] DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000976; GO:0001216; GO:0005829; GO:0006351; GO:0010038; GO:0032993 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A8U6 METJ_ECOLI Met repressor (Met regulon regulatory protein MetJ) metJ b3938 JW3909 metJ 12,141 methionine biosynthetic process [GO:0009086]; negative regulation of transcription, DNA-templated [GO:0045892] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; methionine biosynthetic process [GO:0009086]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0005829; GO:0009086; GO:0045892 SUBCELLULAR LOCATION: Cytoplasm. +P0ACH8 MELR_ECOLI Melibiose operon regulatory protein melR b4118 JW4079 melR 34,928 regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003677; GO:0003700; GO:0006355; GO:0043565 +P30748 MOAD_ECOLI Molybdopterin synthase sulfur carrier subunit (MPT synthase subunit 1) (Molybdenum cofactor biosynthesis protein D) (Molybdopterin-converting factor small subunit) (Molybdopterin-converting factor subunit 1) (Sulfur carrier protein MoaD) moaD chlA4 chlM b0784 JW0767 chlA4 chlM moaD 8,758 Mo-molybdopterin cofactor biosynthetic process [GO:0006777] cytosol [GO:0005829] cytosol [GO:0005829]; nucleotide binding [GO:0000166]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777] nucleotide binding [GO:0000166] GO:0000166; GO:0005829; GO:0006777 +P0A738 MOAC_ECOLI Cyclic pyranopterin monophosphate synthase (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C) moaC chlA3 b0783 JW0766 chlA3 moaC 17,467 Mo-molybdopterin cofactor biosynthetic process [GO:0006777] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; cyclic pyranopterin monophosphate synthase activity [GO:0061799]; identical protein binding [GO:0042802]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777] cyclic pyranopterin monophosphate synthase activity [GO:0061799]; identical protein binding [GO:0042802] GO:0006777; GO:0032991; GO:0042802; GO:0061799 +P0A9I5 NAPD_ECOLI Chaperone NapD (NapA signal peptide-binding chaperone NapD) napD yojF b2207 JW2195 yojF napD 9,469 negative regulation of protein transport [GO:0051224] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; signal sequence binding [GO:0005048]; negative regulation of protein transport [GO:0051224] signal sequence binding [GO:0005048] GO:0005048; GO:0005737; GO:0051224 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02200, ECO:0000269|PubMed:17901208}. +P0AFA5 NFRB_ECOLI Bacteriophage adsorption protein B (Bacteriophage N4 adsorption protein B) nfrB b0569 JW0558 nfrB 85,319 protein secretion by the type II secretion system [GO:0015628] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627]; protein secretion by the type II secretion system [GO:0015628] GO:0005886; GO:0005887; GO:0015627; GO:0015628 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P38489 NFSB_ECOLI Oxygen-insensitive NAD(P)H nitroreductase (EC 1.-.-.-) (Dihydropteridine reductase) (EC 1.5.1.34) (FMN-dependent nitroreductase) nfsB dprA nfnB nfsI ntr b0578 JW0567 dprA nfnB nfsI ntr nfsB 23,905 2,4,6-trinitrotoluene catabolic process [GO:0046256] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; 6,7-dihydropteridine reductase activity [GO:0004155]; FMN binding [GO:0010181]; identical protein binding [GO:0042802]; NAD(P)H nitroreductase activity [GO:0018545]; oxidoreductase activity [GO:0016491]; 2,4,6-trinitrotoluene catabolic process [GO:0046256] 6,7-dihydropteridine reductase activity [GO:0004155]; FMN binding [GO:0010181]; identical protein binding [GO:0042802]; NAD(P)H nitroreductase activity [GO:0018545]; oxidoreductase activity [GO:0016491] GO:0004155; GO:0005829; GO:0010181; GO:0016020; GO:0016491; GO:0018545; GO:0042802; GO:0046256 +P32675 PFLC_ECOLI Pyruvate formate-lyase 2-activating enzyme (EC 1.97.1.4) (Formate-C-acetyltransferase-activating enzyme 2) (PFL-activating enzyme 2) pflC yijM b3952 JW3924 yijM pflC 32,430 glucose metabolic process [GO:0006006] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 4 iron, 4 sulfur cluster binding [GO:0051539]; [formate-C-acetyltransferase]-activating enzyme activity [GO:0043365]; metal ion binding [GO:0046872]; glucose metabolic process [GO:0006006] [formate-C-acetyltransferase]-activating enzyme activity [GO:0043365]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0005737; GO:0006006; GO:0043365; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P0AFM2 PROX_ECOLI Glycine betaine/proline betaine-binding periplasmic protein (GBBP) proX proU b2679 JW2654 proU proX 36,023 amino acid transport [GO:0006865]; glycine betaine transport [GO:0031460]; hyperosmotic response [GO:0006972] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288]; quaternary ammonium group binding [GO:0050997]; transmembrane transporter activity [GO:0022857]; amino acid transport [GO:0006865]; glycine betaine transport [GO:0031460]; hyperosmotic response [GO:0006972] quaternary ammonium group binding [GO:0050997]; transmembrane transporter activity [GO:0022857] GO:0006865; GO:0006972; GO:0022857; GO:0030288; GO:0031460; GO:0043190; GO:0050997 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:3305496, ECO:0000269|PubMed:7898450}. +P00550 PTM3C_ECOLI PTS system mannitol-specific EIICBA component (EIICBA-Mtl) (EII-Mtl) [Includes: Mannitol permease IIC component (PTS system mannitol-specific EIIC component); Mannitol-specific phosphotransferase enzyme IIB component (EC 2.7.1.197) (PTS system mannitol-specific EIIB component); Mannitol-specific phosphotransferase enzyme IIA component (PTS system mannitol-specific EIIA component)] mtlA b3599 JW3573 mtlA 67,972 mannitol transport [GO:0015797]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity [GO:0022872]; protein-phosphocysteine-mannitol phosphotransferase system transporter activity [GO:0090565]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; mannitol transport [GO:0015797]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity [GO:0022872]; protein-phosphocysteine-mannitol phosphotransferase system transporter activity [GO:0090565]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005886; GO:0005887; GO:0009401; GO:0015797; GO:0016301; GO:0022872; GO:0090563; GO:0090565 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00427, ECO:0000269|PubMed:15919996, ECO:0000305|PubMed:6309813}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00427, ECO:0000269|PubMed:15919996, ECO:0000305|PubMed:368051}. +P69808 PTFB1_ECOLI PTS system fructose-like EIIB component 1 (EC 2.7.1.202) (Fructose-like phosphotransferase enzyme IIB component 1) fryB ypdH b2387 JW5389 ypdH fryB 11,735 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity [GO:0022877]; protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity [GO:0090582]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity [GO:0022877]; protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity [GO:0090582]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005737; GO:0005886; GO:0009401; GO:0016301; GO:0022877; GO:0090563; GO:0090582 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P69795 PTQB_ECOLI PTS system N,N'-diacetylchitobiose-specific EIIB component (EIIB-Chb) (IVcel) (N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIB component) (EC 2.7.1.196) chbB celA b1738 JW1727 celA chbB 11,427 N,N'-diacetylchitobiose import [GO:1902815]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytosol [GO:0005829] cytosol [GO:0005829]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity [GO:0090566]; N,N'-diacetylchitobiose import [GO:1902815]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity [GO:0090566] GO:0005829; GO:0008982; GO:0009401; GO:0016301; GO:0090566; GO:1902815 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A7E9 PYRH_ECOLI Uridylate kinase (UK) (EC 2.7.4.22) (Uridine monophosphate kinase) (UMP kinase) (UMPK) pyrH smbA b0171 JW0166 smbA pyrH 25,970 'de novo' CTP biosynthetic process [GO:0044210]; pyrimidine nucleotide biosynthetic process [GO:0006221]; UDP biosynthetic process [GO:0006225] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; UMP kinase activity [GO:0033862]; 'de novo' CTP biosynthetic process [GO:0044210]; pyrimidine nucleotide biosynthetic process [GO:0006221]; UDP biosynthetic process [GO:0006225] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; UMP kinase activity [GO:0033862] GO:0005524; GO:0005829; GO:0006221; GO:0006225; GO:0033862; GO:0042802; GO:0044210 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9922246}. Note=Is predominantly localized near the bacterial membranes. +P0A7F3 PYRI_ECOLI Aspartate carbamoyltransferase regulatory chain pyrI b4244 JW4203 pyrI 17,121 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; pyrimidine nucleotide biosynthetic process [GO:0006221] aspartate carbamoyltransferase complex [GO:0009347]; cytoplasm [GO:0005737] aspartate carbamoyltransferase complex [GO:0009347]; cytoplasm [GO:0005737]; zinc ion binding [GO:0008270]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; pyrimidine nucleotide biosynthetic process [GO:0006221] zinc ion binding [GO:0008270] GO:0005737; GO:0006207; GO:0006221; GO:0008270; GO:0009347 +P0AF93 RIDA_ECOLI 2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (Enamine/imine deaminase) ridA yjgF b4243 JW5755 yjgF ridA 13,612 cellular amino acid biosynthetic process [GO:0008652]; isoleucine biosynthetic process [GO:0009097]; organonitrogen compound catabolic process [GO:1901565]; protein homotrimerization [GO:0070207]; response to toxic substance [GO:0009636] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; 2-iminobutanoate deaminase activity [GO:0120242]; 2-iminopropanoate deaminase activity [GO:0120243]; deaminase activity [GO:0019239]; identical protein binding [GO:0042802]; unfolded protein binding [GO:0051082]; cellular amino acid biosynthetic process [GO:0008652]; isoleucine biosynthetic process [GO:0009097]; organonitrogen compound catabolic process [GO:1901565]; protein homotrimerization [GO:0070207]; response to toxic substance [GO:0009636] 2-iminobutanoate deaminase activity [GO:0120242]; 2-iminopropanoate deaminase activity [GO:0120243]; deaminase activity [GO:0019239]; identical protein binding [GO:0042802]; unfolded protein binding [GO:0051082] GO:0005829; GO:0008652; GO:0009097; GO:0009636; GO:0016020; GO:0019239; GO:0042802; GO:0051082; GO:0070207; GO:0120242; GO:0120243; GO:1901565 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P09980 REP_ECOLI ATP-dependent DNA helicase Rep (EC 3.6.4.12) rep b3778 JW5604 rep 77,024 bacterial-type DNA replication [GO:0044787]; DNA unwinding involved in DNA replication [GO:0006268]; recombinational repair [GO:0000725]; response to radiation [GO:0009314] cytosol [GO:0005829] cytosol [GO:0005829]; 3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697]; bacterial-type DNA replication [GO:0044787]; DNA unwinding involved in DNA replication [GO:0006268]; recombinational repair [GO:0000725]; response to radiation [GO:0009314] 3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697] GO:0000725; GO:0003678; GO:0003697; GO:0005524; GO:0005829; GO:0006268; GO:0008408; GO:0009314; GO:0043138; GO:0044787 +P09377 RHAS_ECOLI HTH-type transcriptional activator RhaS (L-rhamnose operon regulatory protein RhaS) rhaS rhaC2 b3905 JW3876 rhaC2 rhaS 32,315 positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; rhamnose metabolic process [GO:0019299] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; rhamnose metabolic process [GO:0019299] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0005737; GO:0006355; GO:0019299; GO:0043565; GO:0045893 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01534}. +P0A7J3 RL10_ECOLI 50S ribosomal protein L10 (50S ribosomal protein L8) (Large ribosomal subunit protein uL10) rplJ b3985 JW3948 rplJ 17,712 negative regulation of translation [GO:0017148]; ribosome biogenesis [GO:0042254]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934]; large ribosomal subunit rRNA binding [GO:0070180]; ribosome binding [GO:0043022]; structural constituent of ribosome [GO:0003735]; negative regulation of translation [GO:0017148]; ribosome biogenesis [GO:0042254]; translation [GO:0006412] large ribosomal subunit rRNA binding [GO:0070180]; ribosome binding [GO:0043022]; structural constituent of ribosome [GO:0003735] GO:0003735; GO:0005829; GO:0006412; GO:0015934; GO:0017148; GO:0022625; GO:0042254; GO:0043022; GO:0070180 +P67697 HICB_ECOLI Antitoxin HicB hicB ydcQ b1438 JW1433 ydcQ hicB 15,247 DNA binding [GO:0003677] DNA binding [GO:0003677] GO:0003677 +P60955 LGT_ECOLI Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase (EC 2.5.1.145) (Prolipoprotein diacylglyceryl transferase) lgt umpA b2828 JW2796 umpA lgt 33,108 lipoprotein biosynthetic process [GO:0042158] cytoplasmic side of plasma membrane [GO:0009898]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cytoplasmic side of plasma membrane [GO:0009898]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity [GO:0008961]; lipoprotein biosynthetic process [GO:0042158] phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity [GO:0008961] GO:0005886; GO:0005887; GO:0008961; GO:0009898; GO:0042158 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01147, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:22287519, ECO:0000269|PubMed:26729647}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01147, ECO:0000269|PubMed:22287519, ECO:0000269|PubMed:26729647}. +P0A8P1 LFTR_ECOLI Leucyl/phenylalanyl-tRNA--protein transferase (EC 2.3.2.6) (L/F-transferase) (Leucyltransferase) (Phenyalanyltransferase) aat ycaA b0885 JW0868 ycaA aat 26,619 protein catabolic process [GO:0030163] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; leucyltransferase activity [GO:0008914]; transferase activity, transferring amino-acyl groups [GO:0016755]; protein catabolic process [GO:0030163] leucyltransferase activity [GO:0008914]; transferase activity, transferring amino-acyl groups [GO:0016755] GO:0005737; GO:0008914; GO:0016755; GO:0030163 SUBCELLULAR LOCATION: Cytoplasm. +P61316 LOLA_ECOLI Outer-membrane lipoprotein carrier protein (P20) lolA lplA yzzV b0891 JW0874 lplA yzzV lolA 22,497 lipoprotein localization to outer membrane [GO:0044874]; lipoprotein transport [GO:0042953] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; lipoprotein localization to outer membrane [GO:0044874]; lipoprotein transport [GO:0042953] GO:0030288; GO:0042953; GO:0044874 SUBCELLULAR LOCATION: Periplasm. +P62522 LPID_ECOLI ilv operon leader peptide (ilvGMEDA operon attenuator peptide) ilvL b3766 JW3739 ilvL 3,231 branched-chain amino acid biosynthetic process [GO:0009082]; cellular amino acid biosynthetic process [GO:0008652]; transcriptional attenuation [GO:0031555] branched-chain amino acid biosynthetic process [GO:0009082]; cellular amino acid biosynthetic process [GO:0008652]; transcriptional attenuation [GO:0031555] GO:0008652; GO:0009082; GO:0031555 +P32099 LPLA_ECOLI Lipoate-protein ligase A (EC 6.3.1.20) (Lipoate--protein ligase) lplA yjjF b4386 JW4349 yjjF lplA 37,926 protein lipoylation [GO:0009249] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; lipoate-protein ligase activity [GO:0016979]; lipoyltransferase activity [GO:0017118]; protein lipoylation [GO:0009249] ATP binding [GO:0005524]; lipoate-protein ligase activity [GO:0016979]; lipoyltransferase activity [GO:0017118] GO:0005524; GO:0005737; GO:0005829; GO:0009249; GO:0016979; GO:0017118 SUBCELLULAR LOCATION: Cytoplasm. +P23930 LNT_ECOLI Apolipoprotein N-acyltransferase (ALP N-acyltransferase) (EC 2.3.1.269) (Copper homeostasis protein CutE) lnt cutE b0657 JW0654 cutE lnt 57,066 lipoprotein biosynthetic process [GO:0042158] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; N-acyltransferase activity [GO:0016410]; lipoprotein biosynthetic process [GO:0042158] N-acyltransferase activity [GO:0016410] GO:0005886; GO:0005887; GO:0016410; GO:0030288; GO:0042158 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01148, ECO:0000269|PubMed:15513925, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2032623, ECO:0000269|PubMed:28675161, ECO:0000269|PubMed:28885614}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01148, ECO:0000269|PubMed:15513925, ECO:0000269|PubMed:28675161, ECO:0000269|PubMed:28885614}. +P06993 MALT_ECOLI HTH-type transcriptional regulator MalT (ATP-dependent transcriptional activator MalT) malT malA b3418 JW3381 malA malT 103,118 carbohydrate metabolic process [GO:0005975]; positive regulation of carbohydrate metabolic process [GO:0045913]; positive regulation of transcription, DNA-templated [GO:0045893] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; trisaccharide binding [GO:0048031]; carbohydrate metabolic process [GO:0005975]; positive regulation of carbohydrate metabolic process [GO:0045913]; positive regulation of transcription, DNA-templated [GO:0045893] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; trisaccharide binding [GO:0048031] GO:0003677; GO:0003700; GO:0005524; GO:0005975; GO:0042802; GO:0045893; GO:0045913; GO:0048031 +P0ACE0 MBHM_ECOLI Hydrogenase-2 large chain (HYD2) (EC 1.12.99.6) (Membrane-bound hydrogenase 2 large subunit) (NiFe hydrogenase) hybC b2994 JW2962 hybC 62,491 extrinsic component of periplasmic side of plasma membrane [GO:0031236] extrinsic component of periplasmic side of plasma membrane [GO:0031236]; ferredoxin hydrogenase activity [GO:0008901]; hydrogenase (acceptor) activity [GO:0033748]; nickel cation binding [GO:0016151] ferredoxin hydrogenase activity [GO:0008901]; hydrogenase (acceptor) activity [GO:0033748]; nickel cation binding [GO:0016151] GO:0008901; GO:0016151; GO:0031236; GO:0033748 SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. +P77333 PGRR_ECOLI HTH-type transcriptional regulator PgrR (Regulator of PG recycling) pgrR ycjZ b1328 JW1321 ycjZ pgrR 33,482 bacterial-type flagellum-dependent swarming motility [GO:0071978]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; bacterial-type flagellum-dependent swarming motility [GO:0071978]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003677; GO:0003700; GO:0006351; GO:0043565; GO:0045892; GO:0071978 +P69829 PTSN_ECOLI Nitrogen regulatory protein (Enzyme IIA-NTR) (PTS system EIIA component) (Phosphotransferase enzyme IIA component) ptsN rpoP yhbI b3204 JW3171 rpoP yhbI ptsN 17,960 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; regulation of ion transmembrane transporter activity [GO:0032412]; response to organonitrogen compound [GO:0010243] cytosol [GO:0005829] cytosol [GO:0005829]; enzyme inhibitor activity [GO:0004857]; kinase activity [GO:0016301]; protein kinase activator activity [GO:0030295]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; regulation of ion transmembrane transporter activity [GO:0032412]; response to organonitrogen compound [GO:0010243] enzyme inhibitor activity [GO:0004857]; kinase activity [GO:0016301]; protein kinase activator activity [GO:0030295]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982] GO:0004857; GO:0005829; GO:0008982; GO:0009401; GO:0010243; GO:0016301; GO:0030295; GO:0032412 SUBCELLULAR LOCATION: Cytoplasm. +P22634 MURI_ECOLI Glutamate racemase (EC 5.1.1.3) murI dga glr yijA b3967 JW5550 dga glr yijA murI 31,002 cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] amino-acid racemase activity [GO:0047661]; glutamate racemase activity [GO:0008881]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] amino-acid racemase activity [GO:0047661]; glutamate racemase activity [GO:0008881] GO:0008360; GO:0008881; GO:0009252; GO:0047661; GO:0071555 +P17802 MUTY_ECOLI Adenine DNA glycosylase (EC 3.2.2.31) (A/G-specific adenine glycosylase) mutY micA b2961 JW2928 micA mutY 39,149 base-excision repair [GO:0006284]; mismatch repair [GO:0006298] 4 iron, 4 sulfur cluster binding [GO:0051539]; 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity [GO:0034039]; adenine/guanine mispair binding [GO:0035485]; metal ion binding [GO:0046872]; oxidized purine DNA binding [GO:0032357]; purine-specific mismatch base pair DNA N-glycosylase activity [GO:0000701]; base-excision repair [GO:0006284]; mismatch repair [GO:0006298] 4 iron, 4 sulfur cluster binding [GO:0051539]; 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity [GO:0034039]; adenine/guanine mispair binding [GO:0035485]; metal ion binding [GO:0046872]; oxidized purine DNA binding [GO:0032357]; purine-specific mismatch base pair DNA N-glycosylase activity [GO:0000701] GO:0000701; GO:0006284; GO:0006298; GO:0032357; GO:0034039; GO:0035485; GO:0046872; GO:0051539 +P33593 NIKD_ECOLI Nickel import ATP-binding protein NikD (EC 7.2.2.11) nikD b3479 JW3444 nikD 26,820 nickel cation transmembrane transport [GO:0035444]; oligopeptide transmembrane transport [GO:0035672]; transmembrane transport [GO:0055085] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ABC-type nickel transporter activity [GO:0015413]; ATP binding [GO:0005524]; nickel cation binding [GO:0016151]; oligopeptide transmembrane transporter activity [GO:0035673]; transmembrane transporter activity [GO:0022857]; nickel cation transmembrane transport [GO:0035444]; oligopeptide transmembrane transport [GO:0035672]; transmembrane transport [GO:0055085] ABC-type nickel transporter activity [GO:0015413]; ATP binding [GO:0005524]; nickel cation binding [GO:0016151]; oligopeptide transmembrane transporter activity [GO:0035673]; transmembrane transporter activity [GO:0022857] GO:0005524; GO:0005886; GO:0015413; GO:0016151; GO:0022857; GO:0035444; GO:0035672; GO:0035673; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01711}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01711}. +P0AFH6 OPPC_ECOLI Oligopeptide transport system permease protein OppC oppC b1245 JW1237 oppC 33,022 protein transport [GO:0015031]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein transport [GO:0015031]; transmembrane transport [GO:0055085] GO:0005886; GO:0015031; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AFF2 NUPC_ECOLI Nucleoside permease NupC (Nucleoside-transport system protein NupC) nupC cru b2393 JW2389 cru nupC 43,476 nucleoside transmembrane transport [GO:1901642]; nucleoside transport [GO:0015858] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cytidine transmembrane transporter activity [GO:0015212]; nucleoside transmembrane transporter activity [GO:0005337]; nucleoside:proton symporter activity [GO:0015506]; symporter activity [GO:0015293]; uridine transmembrane transporter activity [GO:0015213]; nucleoside transmembrane transport [GO:1901642]; nucleoside transport [GO:0015858] cytidine transmembrane transporter activity [GO:0015212]; nucleoside:proton symporter activity [GO:0015506]; nucleoside transmembrane transporter activity [GO:0005337]; symporter activity [GO:0015293]; uridine transmembrane transporter activity [GO:0015213] GO:0005337; GO:0005886; GO:0005887; GO:0015212; GO:0015213; GO:0015293; GO:0015506; GO:0015858; GO:1901642 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P0A912 PAL_ECOLI Peptidoglycan-associated lipoprotein (PAL) (Tol-Pal system lipoprotein Pal) pal excC b0741 JW0731 excC pal 18,824 cell cycle [GO:0007049]; cell division [GO:0051301] cell division site [GO:0032153]; cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; intrinsic component of periplasmic side of cell outer membrane [GO:0031246] cell division site [GO:0032153]; cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; intrinsic component of periplasmic side of cell outer membrane [GO:0031246]; cell cycle [GO:0007049]; cell division [GO:0051301] GO:0007049; GO:0009279; GO:0016021; GO:0031246; GO:0032153; GO:0051301 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_02204, ECO:0000269|PubMed:1574003}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_02204, ECO:0000269|PubMed:1574003}. Note=Accumulates at cell constriction sites. Recruitment to the division site is dependent on FtsN activity. {ECO:0000269|PubMed:17233825}. +P0AA04 PTHP_ECOLI Phosphocarrier protein HPr (Histidine-containing protein) ptsH hpr b2415 JW2408 hpr ptsH 9,119 negative regulation of kinase activity [GO:0033673]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; positive regulation of glycogen catabolic process [GO:0045819] cytosol [GO:0005829] cytosol [GO:0005829]; antisigma factor binding [GO:0045152]; enzyme activator activity [GO:0008047]; enzyme inhibitor activity [GO:0004857]; negative regulation of kinase activity [GO:0033673]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; positive regulation of glycogen catabolic process [GO:0045819] antisigma factor binding [GO:0045152]; enzyme activator activity [GO:0008047]; enzyme inhibitor activity [GO:0004857] GO:0004857; GO:0005829; GO:0008047; GO:0009401; GO:0033673; GO:0045152; GO:0045819 SUBCELLULAR LOCATION: Cytoplasm. +P56579 PTHC_ECOLI PTS system glucitol/sorbitol-specific EIIC component (EIIC-Gut) (Glucitol/sorbitol permease IIC component) srlA gutA sbl b2702 JW5429 gutA sbl srlA 20,580 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] GO:0005886; GO:0009401; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00430, ECO:0000305|PubMed:3553176}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00430, ECO:0000305|PubMed:3553176}. +P37906 PUUB_ECOLI Gamma-glutamylputrescine oxidoreductase (Gamma-Glu-Put oxidase) (Gamma-glutamylputrescine oxidase) (EC 1.4.3.-) puuB ordL ycjA b1301 JW1294 ordL ycjA puuB 47,170 putrescine catabolic process [GO:0009447] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; oxidoreductase activity [GO:0016491]; putrescine catabolic process [GO:0009447] oxidoreductase activity [GO:0016491] GO:0005737; GO:0009447; GO:0016491 +P76037 PUUP_ECOLI Putrescine importer PuuP puuP ycjJ b1296 JW1289 ycjJ puuP 50,853 amino acid transport [GO:0006865]; cellular response to DNA damage stimulus [GO:0006974]; putrescine catabolic process [GO:0009447]; putrescine transport [GO:0015847] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; putrescine transmembrane transporter activity [GO:0015489]; solute:proton symporter activity [GO:0015295]; amino acid transport [GO:0006865]; cellular response to DNA damage stimulus [GO:0006974]; putrescine catabolic process [GO:0009447]; putrescine transport [GO:0015847] putrescine transmembrane transporter activity [GO:0015489]; solute:proton symporter activity [GO:0015295] GO:0005886; GO:0006865; GO:0006974; GO:0009447; GO:0015295; GO:0015489; GO:0015847; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P68183 MALG_ECOLI Maltose/maltodextrin transport system permease protein MalG malG b4032 JW3992 malG 32,225 maltodextrin transport [GO:0042956]; maltose transport [GO:0015768] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; maltose transport complex [GO:1990060]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; maltose transport complex [GO:1990060]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ABC-type maltose transporter activity [GO:0015423]; maltodextrin transport [GO:0042956]; maltose transport [GO:0015768] ABC-type maltose transporter activity [GO:0015423] GO:0005886; GO:0005887; GO:0015423; GO:0015768; GO:0016020; GO:0042956; GO:0043190; GO:1990060 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:18456666, ECO:0000269|PubMed:2233678}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:18456666, ECO:0000269|PubMed:2233678}. +P30750 METN_ECOLI Methionine import ATP-binding protein MetN (EC 7.4.2.11) metN abc b0199 JW0195 abc metN 37,788 D-methionine transport [GO:0048473]; metabolic process [GO:0008152] ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; Gram-negative-bacterium-type cell wall [GO:0009276] ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; Gram-negative-bacterium-type cell wall [GO:0009276]; ABC-type D-methionine transporter activity [GO:0033232]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; L-methionine transmembrane transporter activity [GO:0015191]; D-methionine transport [GO:0048473]; metabolic process [GO:0008152] ABC-type D-methionine transporter activity [GO:0033232]; ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; L-methionine transmembrane transporter activity [GO:0015191] GO:0005524; GO:0008152; GO:0009276; GO:0015191; GO:0016887; GO:0033232; GO:0042626; GO:0048473; GO:0055052 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01719, ECO:0000305}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01719, ECO:0000305}. +P33554 PPDA_ECOLI Prepilin peptidase-dependent protein A ppdA b2826 JW2794 ppdA 17,865 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021] GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. +P0A7A5 PIMT_ECOLI Protein-L-isoaspartate O-methyltransferase (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) (PIMT) pcm b2743 JW2713 pcm 23,258 protein repair [GO:0030091] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719]; protein repair [GO:0030091] protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719] GO:0004719; GO:0005737; GO:0030091 SUBCELLULAR LOCATION: Cytoplasm. +P45577 PROQ_ECOLI RNA chaperone ProQ proQ yebJ yobE yoeC b1831 JW5300 yebJ yobE yoeC proQ 25,893 cellular hyperosmotic salinity response [GO:0071475]; cellular response to DNA damage stimulus [GO:0006974]; osmosensory signaling pathway [GO:0007231]; positive regulation of proline import across plasma membrane [GO:1902836]; posttranscriptional regulation of gene expression [GO:0010608]; single-species biofilm formation [GO:0044010] cytosol [GO:0005829] cytosol [GO:0005829]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA strand annealing activity [GO:0033592]; RNA strand-exchange activity [GO:0034057]; cellular hyperosmotic salinity response [GO:0071475]; cellular response to DNA damage stimulus [GO:0006974]; osmosensory signaling pathway [GO:0007231]; positive regulation of proline import across plasma membrane [GO:1902836]; posttranscriptional regulation of gene expression [GO:0010608]; single-species biofilm formation [GO:0044010] mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA strand annealing activity [GO:0033592]; RNA strand-exchange activity [GO:0034057] GO:0003729; GO:0003730; GO:0005829; GO:0006974; GO:0007231; GO:0010608; GO:0033592; GO:0034057; GO:0044010; GO:0071475; GO:1902836 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00749, ECO:0000269|PubMed:10049386, ECO:0000269|PubMed:15476391}. +P09323 PTW3C_ECOLI PTS system N-acetylglucosamine-specific EIICBA component (EIICBA-Nag) (EII-Nag) [Includes: N-acetylglucosamine permease IIC component (PTS system N-acetylglucosamine-specific EIIC component); N-acetylglucosamine-specific phosphotransferase enzyme IIB component (EC 2.7.1.193) (PTS system N-acetylglucosamine-specific EIIB component); N-acetylglucosamine-specific phosphotransferase enzyme IIA component (PTS system N-acetylglucosamine-specific EIIA component)] nagE pstN b0679 JW0665 pstN nagE 68,347 cellular response to DNA damage stimulus [GO:0006974]; N-acetylglucosamine transport [GO:0015764]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of plasma membrane [GO:0005887]; organelle inner membrane [GO:0019866] integral component of plasma membrane [GO:0005887]; organelle inner membrane [GO:0019866]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; N-acetylglucosamine transmembrane transporter activity [GO:0015572]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-glucosamine phosphotransferase system transporter activity [GO:0090587]; protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity [GO:0090586]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; cellular response to DNA damage stimulus [GO:0006974]; N-acetylglucosamine transport [GO:0015764]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; metal ion binding [GO:0046872]; N-acetylglucosamine transmembrane transporter activity [GO:0015572]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-glucosamine phosphotransferase system transporter activity [GO:0090587]; protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity [GO:0090586]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005887; GO:0006974; GO:0008982; GO:0009401; GO:0015572; GO:0015764; GO:0016301; GO:0019866; GO:0046872; GO:0090563; GO:0090586; GO:0090587 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00426, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00426, ECO:0000269|PubMed:15919996}. +P75685 RCLC_ECOLI Inner membrane protein RclC (Reactive chlorine resistance protein C) rclC ykgB b0301 JW5038 ykgB rclC 21,899 response to hypochlorite [GO:1901530] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; response to hypochlorite [GO:1901530] GO:0005886; GO:0016021; GO:1901530 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P21893 RECJ_ECOLI Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-) recJ b2892 JW2860 recJ 63,389 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; response to X-ray [GO:0010165] nucleic acid binding [GO:0003676]; single-stranded DNA 5'-3' exodeoxyribonuclease activity [GO:0045145]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; response to X-ray [GO:0010165] nucleic acid binding [GO:0003676]; single-stranded DNA 5'-3' exodeoxyribonuclease activity [GO:0045145] GO:0003676; GO:0006281; GO:0006310; GO:0010165; GO:0045145 +P41409 RIHA_ECOLI Pyrimidine-specific ribonucleoside hydrolase RihA (EC 3.2.-.-) (Cytidine/uridine-specific hydrolase) rihA ybeK b0651 JW0646 ybeK rihA 33,823 nucleobase-containing small molecule interconversion [GO:0015949]; protein homotetramerization [GO:0051289]; purine nucleoside catabolic process [GO:0006152]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine ribonucleoside catabolic process [GO:0046133] cytosol [GO:0005829] cytosol [GO:0005829]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; purine nucleosidase activity [GO:0008477]; ribosylpyrimidine nucleosidase activity [GO:0050263]; uridine nucleosidase activity [GO:0045437]; nucleobase-containing small molecule interconversion [GO:0015949]; protein homotetramerization [GO:0051289]; purine nucleoside catabolic process [GO:0006152]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine ribonucleoside catabolic process [GO:0046133] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; purine nucleosidase activity [GO:0008477]; ribosylpyrimidine nucleosidase activity [GO:0050263]; uridine nucleosidase activity [GO:0045437] GO:0005509; GO:0005829; GO:0006152; GO:0006206; GO:0008477; GO:0015949; GO:0042802; GO:0045437; GO:0046133; GO:0050263; GO:0051289 +P0AG38 RHTC_ECOLI Threonine efflux protein rhtC yigJ b3823 JW5586 yigJ rhtC 22,474 amino acid transport [GO:0006865]; threonine transport [GO:0015826] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; amino acid transmembrane transporter activity [GO:0015171]; threonine efflux transmembrane transporter activity [GO:0015565]; amino acid transport [GO:0006865]; threonine transport [GO:0015826] amino acid transmembrane transporter activity [GO:0015171]; threonine efflux transmembrane transporter activity [GO:0015565] GO:0005887; GO:0006865; GO:0015171; GO:0015565; GO:0015826 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P27241 RFAZ_ECOLI Lipopolysaccharide core biosynthesis protein RfaZ rfaZ b3624 JW3599 rfaZ 32,920 lipopolysaccharide core region biosynthetic process [GO:0009244] lipopolysaccharide core region biosynthetic process [GO:0009244] GO:0009244 +P0A948 RIMJ_ECOLI [Ribosomal protein S5]-alanine N-acetyltransferase (EC 2.3.1.267) (Acetylating enzyme for N-terminal of ribosomal protein S5) rimJ b1066 JW1053 rimJ 22,688 cellular protein modification process [GO:0006464]; maturation of SSU-rRNA [GO:0030490]; N-terminal peptidyl-alanine acetylation [GO:0017189]; N-terminal peptidyl-serine acetylation [GO:0017198]; N-terminal protein amino acid acetylation [GO:0006474]; ribosome biogenesis [GO:0042254] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribosomal-protein-alanine N-acetyltransferase complex [GO:0009323] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribosomal-protein-alanine N-acetyltransferase complex [GO:0009323]; N-acetyltransferase activity [GO:0008080]; peptide-serine-N-acetyltransferase activity [GO:1990189]; ribosomal-protein-alanine N-acetyltransferase activity [GO:0008999]; cellular protein modification process [GO:0006464]; maturation of SSU-rRNA [GO:0030490]; N-terminal peptidyl-alanine acetylation [GO:0017189]; N-terminal peptidyl-serine acetylation [GO:0017198]; N-terminal protein amino acid acetylation [GO:0006474]; ribosome biogenesis [GO:0042254] N-acetyltransferase activity [GO:0008080]; peptide-serine-N-acetyltransferase activity [GO:1990189]; ribosomal-protein-alanine N-acetyltransferase activity [GO:0008999] GO:0005737; GO:0005829; GO:0006464; GO:0006474; GO:0008080; GO:0008999; GO:0009323; GO:0017189; GO:0017198; GO:0030490; GO:0042254; GO:1990189 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P16918 RHSC_ECOLI Protein RhsC rhsC b0700 JW0689 rhsC 157,776 +P32170 RHAA_ECOLI L-rhamnose isomerase (EC 5.3.1.14) rhaA b3903 JW5561 rhaA 47,199 L-lyxose metabolic process [GO:0019324]; rhamnose catabolic process [GO:0019301] cytoplasm [GO:0005737]; protein-containing complex [GO:0032991] cytoplasm [GO:0005737]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; L-rhamnose isomerase activity [GO:0008740]; manganese ion binding [GO:0030145]; rhamnose binding [GO:0033296]; zinc ion binding [GO:0008270]; L-lyxose metabolic process [GO:0019324]; rhamnose catabolic process [GO:0019301] identical protein binding [GO:0042802]; L-rhamnose isomerase activity [GO:0008740]; manganese ion binding [GO:0030145]; rhamnose binding [GO:0033296]; zinc ion binding [GO:0008270] GO:0005737; GO:0008270; GO:0008740; GO:0019301; GO:0019324; GO:0030145; GO:0032991; GO:0033296; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A7J7 RL11_ECOLI 50S ribosomal protein L11 (Large ribosomal subunit protein uL11) rplK relC b3983 JW3946 relC rplK 14,875 ribosomal large subunit assembly [GO:0000027]; stringent response [GO:0015968]; translation [GO:0006412]; translational termination [GO:0006415] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934]; large ribosomal subunit rRNA binding [GO:0070180]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; ribosomal large subunit assembly [GO:0000027]; stringent response [GO:0015968]; translation [GO:0006412]; translational termination [GO:0006415] large ribosomal subunit rRNA binding [GO:0070180]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GO:0000027; GO:0003735; GO:0005829; GO:0006412; GO:0006415; GO:0015934; GO:0015968; GO:0019843; GO:0022625; GO:0070180 +P75948 THIK_ECOLI Thiamine kinase (EC 2.7.1.89) thiK ycfN b1106 JW1092 ycfN thiK 32,397 thiamine diphosphate biosynthetic process [GO:0009229]; thiamine metabolic process [GO:0006772] ATP binding [GO:0005524]; thiamine kinase activity [GO:0019165]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine metabolic process [GO:0006772] ATP binding [GO:0005524]; thiamine kinase activity [GO:0019165] GO:0005524; GO:0006772; GO:0009229; GO:0019165 +P06612 TOP1_ECOLI DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Swivelase) (Untwisting enzyme) topA supX b1274 JW1266 supX topA 97,350 DNA topological change [GO:0006265] chromosome [GO:0005694]; cytosol [GO:0005829] chromosome [GO:0005694]; cytosol [GO:0005829]; DNA binding [GO:0003677]; DNA topoisomerase activity [GO:0003916]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; metal ion binding [GO:0046872]; DNA topological change [GO:0006265] DNA binding [GO:0003677]; DNA topoisomerase activity [GO:0003916]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; metal ion binding [GO:0046872] GO:0003677; GO:0003916; GO:0003917; GO:0005694; GO:0005829; GO:0006265; GO:0046872 +P0AB18 TUSE_ECOLI Sulfurtransferase TusE (EC 2.8.1.-) (tRNA 2-thiouridine synthesizing protein E) tusE yccK b0969 JW0952 yccK tusE 12,410 tRNA wobble position uridine thiolation [GO:0002143] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; sulfur carrier activity [GO:0097163]; transferase activity [GO:0016740]; tRNA wobble position uridine thiolation [GO:0002143] sulfur carrier activity [GO:0097163]; transferase activity [GO:0016740] GO:0002143; GO:0005737; GO:0016740; GO:0097163 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +Q46820 UACF_ECOLI Putative oxidoreductase UacF (Uric acid degradation formate-related element) uacF ygfT b2887 JW5469 ygfT uacF 69,089 urate catabolic process [GO:0019628] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; urate catabolic process [GO:0019628] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] GO:0016491; GO:0019628; GO:0046872; GO:0051539 +P0A796 PFKA_ECOLI ATP-dependent 6-phosphofructokinase isozyme 1 (ATP-PFK 1) (Phosphofructokinase 1) (EC 2.7.1.11) (6-phosphofructokinase isozyme I) (Phosphohexokinase 1) pfkA b3916 JW3887 pfkA 34,842 canonical glycolysis [GO:0061621]; cellular carbohydrate catabolic process [GO:0044275]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; glucose catabolic process [GO:0006007]; glycolytic process [GO:0006096] 6-phosphofructokinase complex [GO:0005945]; cytoplasm [GO:0005737]; cytosol [GO:0005829] 6-phosphofructokinase complex [GO:0005945]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; 6-phosphofructokinase activity [GO:0003872]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; fructose-6-phosphate binding [GO:0070095]; GDP binding [GO:0019003]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; monosaccharide binding [GO:0048029]; ribonucleotide binding [GO:0032553]; canonical glycolysis [GO:0061621]; cellular carbohydrate catabolic process [GO:0044275]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; glucose catabolic process [GO:0006007]; glycolytic process [GO:0006096] 6-phosphofructokinase activity [GO:0003872]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; fructose-6-phosphate binding [GO:0070095]; GDP binding [GO:0019003]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; monosaccharide binding [GO:0048029]; ribonucleotide binding [GO:0032553] GO:0000287; GO:0003872; GO:0005524; GO:0005737; GO:0005829; GO:0005945; GO:0006002; GO:0006007; GO:0006096; GO:0016208; GO:0019003; GO:0030388; GO:0032553; GO:0042802; GO:0044275; GO:0048029; GO:0061621; GO:0070095 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00339, ECO:0000305|PubMed:17895580}. +P32140 SQUS_ECOLI Sulfoquinovose isomerase (SQ isomerase) (EC 5.3.1.31) yihS b3880 JW5569 yihS 47,433 6-sulfoquinovose(1-) catabolic process [GO:1902777]; 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde [GO:0061720]; carbohydrate metabolic process [GO:0005975]; protein hexamerization [GO:0034214] identical protein binding [GO:0042802]; mannose isomerase activity [GO:0050089]; sulfoquinovose isomerase activity [GO:0061593]; 6-sulfoquinovose(1-) catabolic process [GO:1902777]; 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde [GO:0061720]; carbohydrate metabolic process [GO:0005975]; protein hexamerization [GO:0034214] identical protein binding [GO:0042802]; mannose isomerase activity [GO:0050089]; sulfoquinovose isomerase activity [GO:0061593] GO:0005975; GO:0034214; GO:0042802; GO:0050089; GO:0061593; GO:0061720; GO:1902777 +P0A850 TIG_ECOLI Trigger factor (TF) (EC 5.2.1.8) (PPIase) tig b0436 JW0426 tig 48,193 'de novo' cotranslational protein folding [GO:0051083]; cell cycle [GO:0007049]; cell division [GO:0051301]; chaperone-mediated protein folding [GO:0061077]; protein transport [GO:0015031]; protein unfolding [GO:0043335]; response to heat [GO:0009408] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; identical protein binding [GO:0042802]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding chaperone [GO:0044183]; ribosome binding [GO:0043022]; 'de novo' cotranslational protein folding [GO:0051083]; cell cycle [GO:0007049]; cell division [GO:0051301]; chaperone-mediated protein folding [GO:0061077]; protein transport [GO:0015031]; protein unfolding [GO:0043335]; response to heat [GO:0009408] identical protein binding [GO:0042802]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding chaperone [GO:0044183]; ribosome binding [GO:0043022] GO:0003755; GO:0005829; GO:0007049; GO:0009408; GO:0015031; GO:0016020; GO:0042802; GO:0043022; GO:0043335; GO:0044183; GO:0051083; GO:0051301; GO:0061077 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8633085}. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm. {ECO:0000269|PubMed:8633085}. +P0AFT2 TCYL_ECOLI L-cystine transport system permease protein TcyL tcyL yecS b1918 JW1903 yecS tcyL 24,801 amino acid transport [GO:0006865]; L-cystine transport [GO:0015811]; sulfur utilization [GO:0006791] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; L-cystine transmembrane transporter activity [GO:0015184]; amino acid transport [GO:0006865]; L-cystine transport [GO:0015811]; sulfur utilization [GO:0006791] L-cystine transmembrane transporter activity [GO:0015184] GO:0005886; GO:0006791; GO:0006865; GO:0015184; GO:0015811; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P52005 TORY_ECOLI Cytochrome c-type protein TorY torY yecK b1873 JW1862 yecK torY 40,286 anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061] Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020] Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; iron ion binding [GO:0005506] GO:0005506; GO:0005887; GO:0009055; GO:0009061; GO:0009276; GO:0016020; GO:0019645; GO:0020037 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. +P0AE01 TRMJ_ECOLI tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ (EC 2.1.1.200) (TrMet(Xm32)) (tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase) (tRNA Cm32/Um32 methyltransferase) trmJ yfhQ b2532 JW2516 yfhQ trmJ 27,048 tRNA nucleoside ribose methylation [GO:0002128] cytosol [GO:0005829] cytosol [GO:0005829]; RNA binding [GO:0003723]; tRNA (cytosine-2'-O-)-methyltransferase activity [GO:0052666]; tRNA (uracil-2'-O-)-methyltransferase activity [GO:0052665]; tRNA nucleoside ribose methylation [GO:0002128] RNA binding [GO:0003723]; tRNA (cytosine-2'-O-)-methyltransferase activity [GO:0052666]; tRNA (uracil-2'-O-)-methyltransferase activity [GO:0052665] GO:0002128; GO:0003723; GO:0005829; GO:0052665; GO:0052666 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +Q47706 UIDC_ECOLI Membrane-associated protein UidC uidC gusC b1615 JW1607 gusC uidC 46,648 carbohydrate transport [GO:0008643] cell outer membrane [GO:0009279]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; pore complex [GO:0046930]; porin activity [GO:0015288]; carbohydrate transport [GO:0008643] porin activity [GO:0015288] GO:0008643; GO:0009279; GO:0015288; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:15774881}. +P0AG03 UBIX_ECOLI Flavin prenyltransferase UbiX (EC 2.5.1.129) ubiX dedF b2311 JW2308 dedF ubiX 20,695 ubiquinone biosynthetic process [GO:0006744] carboxy-lyase activity [GO:0016831]; flavin prenyltransferase activity [GO:0106141]; ubiquinone biosynthetic process [GO:0006744] carboxy-lyase activity [GO:0016831]; flavin prenyltransferase activity [GO:0106141] GO:0006744; GO:0016831; GO:0106141 +P37596 NORW_ECOLI Nitric oxide reductase FlRd-NAD(+) reductase (EC 1.18.1.-) (Flavorubredoxin reductase) (FlRd-reductase) (FlavoRb reductase) norW flrR ygbD b2711 JW2681 flrR ygbD norW 41,404 cellular response to nitric oxide [GO:0071732]; nitric oxide catabolic process [GO:0046210] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [GO:0016731]; rubredoxin-NAD+ reductase activity [GO:0015044]; cellular response to nitric oxide [GO:0071732]; nitric oxide catabolic process [GO:0046210] flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [GO:0016731]; rubredoxin-NAD+ reductase activity [GO:0015044] GO:0005737; GO:0015044; GO:0016731; GO:0046210; GO:0050660; GO:0071732 SUBCELLULAR LOCATION: Cytoplasm. +P0AF63 NSRR_ECOLI HTH-type transcriptional repressor NsrR nsrR yjeB b4178 JW4136 yjeB nsrR 15,593 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; 2 iron, 2 sulfur cluster binding [GO:0051537]; DNA-binding transcription factor activity [GO:0003700]; double-stranded DNA binding [GO:0003690]; iron ion binding [GO:0005506]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] 2 iron, 2 sulfur cluster binding [GO:0051537]; DNA-binding transcription factor activity [GO:0003700]; double-stranded DNA binding [GO:0003690]; iron ion binding [GO:0005506] GO:0003690; GO:0003700; GO:0005506; GO:0005829; GO:0006355; GO:0045892; GO:0051537 +P0AC65 NRDH_ECOLI Glutaredoxin-like protein NrdH nrdH ygaN b2673 JW2648 ygaN nrdH 9,139 cell redox homeostasis [GO:0045454]; positive regulation of oxidoreductase activity [GO:0051353] electron transfer activity [GO:0009055]; protein disulfide oxidoreductase activity [GO:0015035]; cell redox homeostasis [GO:0045454]; positive regulation of oxidoreductase activity [GO:0051353] electron transfer activity [GO:0009055]; protein disulfide oxidoreductase activity [GO:0015035] GO:0009055; GO:0015035; GO:0045454; GO:0051353 +P0AFE0 NUOJ_ECOLI NADH-quinone oxidoreductase subunit J (EC 7.1.1.-) (NADH dehydrogenase I subunit J) (NDH-1 subunit J) (NUO10) nuoJ b2280 JW2275 nuoJ 19,875 integral component of plasma membrane [GO:0005887]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272] integral component of plasma membrane [GO:0005887]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] GO:0005886; GO:0005887; GO:0008137; GO:0030964; GO:0045272; GO:0048038 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P06960 OTC2_ECOLI Ornithine carbamoyltransferase subunit F (OTCase-2) (EC 2.1.3.3) argF b0273 JW0266 argF 36,827 arginine biosynthetic process via ornithine [GO:0042450]; cellular response to DNA damage stimulus [GO:0006974]; citrulline biosynthetic process [GO:0019240] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; amino acid binding [GO:0016597]; metal ion binding [GO:0046872]; ornithine carbamoyltransferase activity [GO:0004585]; arginine biosynthetic process via ornithine [GO:0042450]; cellular response to DNA damage stimulus [GO:0006974]; citrulline biosynthetic process [GO:0019240] amino acid binding [GO:0016597]; metal ion binding [GO:0046872]; ornithine carbamoyltransferase activity [GO:0004585] GO:0004585; GO:0005737; GO:0006974; GO:0016597; GO:0019240; GO:0042450; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0ADB1 OSME_ECOLI Osmotically-inducible putative lipoprotein OsmE (Activator of ntr-like gene protein) osmE anr b1739 JW1728 anr osmE 12,021 response to osmotic stress [GO:0006970] outer membrane [GO:0019867]; plasma membrane [GO:0005886] outer membrane [GO:0019867]; plasma membrane [GO:0005886]; response to osmotic stress [GO:0006970] GO:0005886; GO:0006970; GO:0019867 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P76084 PAAI_ECOLI Acyl-coenzyme A thioesterase PaaI (EC 3.1.2.-) (Phenylacetic acid degradation protein PaaI) paaI ydbV b1396 JW1391 ydbV paaI 14,851 phenylacetate catabolic process [GO:0010124] CoA hydrolase activity [GO:0016289]; phenylacetate catabolic process [GO:0010124] CoA hydrolase activity [GO:0016289] GO:0010124; GO:0016289 +P76078 PAAB_ECOLI 1,2-phenylacetyl-CoA epoxidase, subunit B (1,2-phenylacetyl-CoA monooxygenase, subunit B) paaB ynbF b1389 JW1384 ynbF paaB 10,942 phenylacetate catabolic process [GO:0010124] phenylacetate catabolic process [GO:0010124] GO:0010124 +P76082 PAAF_ECOLI 2,3-dehydroadipyl-CoA hydratase (EC 4.2.1.17) (Enoyl-CoA hydratase) paaF ydbR b1393 JW1388 ydbR paaF 27,237 fatty acid beta-oxidation [GO:0006635]; phenylacetate catabolic process [GO:0010124] enoyl-CoA hydratase activity [GO:0004300]; identical protein binding [GO:0042802]; fatty acid beta-oxidation [GO:0006635]; phenylacetate catabolic process [GO:0010124] enoyl-CoA hydratase activity [GO:0004300]; identical protein binding [GO:0042802] GO:0004300; GO:0006635; GO:0010124; GO:0042802 +P76080 PAAD_ECOLI Putative 1,2-phenylacetyl-CoA epoxidase, subunit D (1,2-phenylacetyl-CoA monooxygenase, subunit D) paaD ydbQ b1391 JW5217 ydbQ paaD 18,324 phenylacetate catabolic process [GO:0010124] phenylacetate catabolic process [GO:0010124] GO:0010124 +P00579 RPOD_ECOLI RNA polymerase sigma factor RpoD (Sigma-70) rpoD alt b3067 JW3039 alt rpoD 70,263 response to heat [GO:0009408]; transcription initiation from bacterial-type RNA polymerase promoter [GO:0001123] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; sigma factor activity [GO:0016987]; response to heat [GO:0009408]; transcription initiation from bacterial-type RNA polymerase promoter [GO:0001123] DNA binding [GO:0003677]; sigma factor activity [GO:0016987] GO:0001123; GO:0003677; GO:0005829; GO:0009408; GO:0016987 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00963}. +P77522 SUFB_ECOLI FeS cluster assembly protein SufB sufB ynhE b1683 JW5273 ynhE sufB 54,745 iron-sulfur cluster assembly [GO:0016226] iron-sulfur cluster assembly complex [GO:1990229] iron-sulfur cluster assembly complex [GO:1990229]; 2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; iron-sulfur cluster assembly [GO:0016226] 2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539] GO:0016226; GO:0051537; GO:0051539; GO:1990229 +P0AGE9 SUCD_ECOLI Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) sucD b0729 JW0718 sucD 29,777 protein autophosphorylation [GO:0046777]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737]; cytosol [GO:0005829]; succinate-CoA ligase complex (ADP-forming) [GO:0009361] cytoplasm [GO:0005737]; cytosol [GO:0005829]; succinate-CoA ligase complex (ADP-forming) [GO:0009361]; nucleotide binding [GO:0000166]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]; succinate-CoA ligase (GDP-forming) activity [GO:0004776]; protein autophosphorylation [GO:0046777]; tricarboxylic acid cycle [GO:0006099] nucleotide binding [GO:0000166]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]; succinate-CoA ligase (GDP-forming) activity [GO:0004776] GO:0000166; GO:0004775; GO:0004776; GO:0005737; GO:0005829; GO:0006099; GO:0009361; GO:0046777 +P04805 SYE_ECOLI Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS) gltX b2400 JW2395 gltX 53,816 glutamyl-tRNA aminoacylation [GO:0006424] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]; glutamyl-tRNA aminoacylation [GO:0006424] ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] GO:0000049; GO:0004818; GO:0005524; GO:0005829; GO:0006424; GO:0008270 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00022}. +P0A8F4 URK_ECOLI Uridine kinase (EC 2.7.1.48) (Cytidine monophosphokinase) (Uridine monophosphokinase) udk b2066 JW2051 udk 24,353 CTP salvage [GO:0044211]; UMP salvage [GO:0044206] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; uridine kinase activity [GO:0004849]; CTP salvage [GO:0044211]; UMP salvage [GO:0044206] ATP binding [GO:0005524]; cytidine kinase activity [GO:0043771]; uridine kinase activity [GO:0004849] GO:0004849; GO:0005524; GO:0005737; GO:0005829; GO:0043771; GO:0044206; GO:0044211 SUBCELLULAR LOCATION: Cytoplasm. +P0A8X2 YCEI_ECOLI Protein YceI yceI b1056 JW1043 yceI 20,912 periplasmic space [GO:0042597] periplasmic space [GO:0042597] GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P75763 YBHI_ECOLI Inner membrane protein YbhI ybhI b0770 JW0753 ybhI 51,351 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P75788 YBIR_ECOLI Inner membrane protein YbiR ybiR b0818 JW0802 ybiR 41,169 transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transport [GO:0055085] GO:0005886; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A8K5 YAEP_ECOLI UPF0253 protein YaeP yaeP b4406 JW0185 yaeP 7,214 +P75860 YCBV_ECOLI Uncharacterized fimbrial-like protein YcbV ycbV b0943 JW5123 ycbV 18,512 cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0009289; GO:0043709; GO:0043711 +P77562 YAIW_ECOLI Uncharacterized protein YaiW yaiW b0378 JW0369 yaiW 40,414 response to peptide [GO:1901652] cytosol [GO:0005829]; external side of cell outer membrane [GO:0031240] cytosol [GO:0005829]; external side of cell outer membrane [GO:0031240]; response to peptide [GO:1901652] GO:0005829; GO:0031240; GO:1901652 +P75914 YCDX_ECOLI Probable phosphatase YcdX (EC 3.1.3.-) ycdX b1034 JW1017 ycdX 26,891 bacterial-type flagellum-dependent swarming motility [GO:0071978] cytosol [GO:0005829] cytosol [GO:0005829]; identical protein binding [GO:0042802]; phosphatase activity [GO:0016791]; phosphoric ester hydrolase activity [GO:0042578]; zinc ion binding [GO:0008270]; bacterial-type flagellum-dependent swarming motility [GO:0071978] identical protein binding [GO:0042802]; phosphatase activity [GO:0016791]; phosphoric ester hydrolase activity [GO:0042578]; zinc ion binding [GO:0008270] GO:0005829; GO:0008270; GO:0016791; GO:0042578; GO:0042802; GO:0071978 +P77746 YBDO_ECOLI Uncharacterized HTH-type transcriptional regulator YbdO ybdO b0603 JW0596 ybdO 34,397 regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006355 +P52048 YGGP_ECOLI Uncharacterized protein YggP yggP b4465 JW5477 yggP 45,818 oxidoreductase activity [GO:0016491] oxidoreductase activity [GO:0016491] GO:0016491 +Q46834 YGHF_ECOLI Putative type II secretion system C-type protein YghF (Putative general secretion pathway C-type protein YghF) yghF b2970 JW5484 yghF 37,349 protein secretion by the type II secretion system [GO:0015628] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627]; protein secretion by the type II secretion system [GO:0015628] GO:0005886; GO:0015627; GO:0015628; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. +P67095 YFCE_ECOLI Phosphodiesterase YfcE (EC 3.1.4.-) yfcE b2300 JW5377 yfcE 20,122 cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; phosphoric diester hydrolase activity [GO:0008081] identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; phosphoric diester hydrolase activity [GO:0008081] GO:0005829; GO:0008081; GO:0030145; GO:0032991; GO:0042802 +P76546 YFFO_ECOLI Uncharacterized protein YffO yffO b2446 yffO 15,729 +P52598 YGBI_ECOLI Uncharacterized HTH-type transcriptional regulator YgbI ygbI b2735 JW2705 ygbI 27,435 DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700 +P45524 YHET_ECOLI Putative esterase YheT (EC 3.1.1.-) yheT b3353 JW3316 yheT 38,495 cellular lipid metabolic process [GO:0044255]; medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty acid catabolic process [GO:0051793] acetylesterase activity [GO:0008126]; acylglycerol lipase activity [GO:0047372]; poly(3-hydroxybutyrate) depolymerase activity [GO:0050526]; short-chain carboxylesterase activity [GO:0034338]; cellular lipid metabolic process [GO:0044255]; medium-chain fatty acid biosynthetic process [GO:0051792]; medium-chain fatty acid catabolic process [GO:0051793] acetylesterase activity [GO:0008126]; acylglycerol lipase activity [GO:0047372]; poly(3-hydroxybutyrate) depolymerase activity [GO:0050526]; short-chain carboxylesterase activity [GO:0034338] GO:0008126; GO:0034338; GO:0044255; GO:0047372; GO:0050526; GO:0051792; GO:0051793 +P33020 YEII_ECOLI Uncharacterized sugar kinase YeiI (EC 2.7.1.-) yeiI b2160 JW2147 yeiI 39,710 kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773] kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773] GO:0016301; GO:0016773 +P63389 YHES_ECOLI Probable ATP-binding protein YheS yheS b3352 JW3315 yheS 71,843 ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0042626 +P76121 YDDH_ECOLI Uncharacterized protein YddH yddH b1462 JW1457 yddH 20,967 FMN binding [GO:0010181] FMN binding [GO:0010181] GO:0010181 +P37630 YHIM_ECOLI Inner membrane protein YhiM yhiM b3491 JW5944 yhiM 37,657 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] GO:0005886; GO:0005887 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +A5A625 YIBV_ECOLI Protein YibV yibV b4615 yibV 12,340 +P0A8K8 YIHY_ECOLI UPF0761 membrane protein YihY yihY b3886 JW3857 b2268 yihY 32,839 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] GO:0005886; GO:0005887 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0ADD5 YJJP_ECOLI Inner membrane protein YjjP yjjP b4364 JW5796 yjjP 28,001 succinate transport [GO:0015744] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; succinate transport [GO:0015744] GO:0005886; GO:0005887; GO:0015744 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P55914 YJJZ_ECOLI Uncharacterized protein YjjZ yjjZ b4567 JW5797 yjjZ 8,697 +P37648 YHJJ_ECOLI Protein YhjJ yhjJ b3527 JW3495 yhjJ 55,527 periplasmic space [GO:0042597] periplasmic space [GO:0042597]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] GO:0008237; GO:0042597; GO:0046872 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P0AEB5 YNAI_ECOLI Low conductance mechanosensitive channel YnaI ynaI b1330 JW1323 ynaI 38,755 ion transport [GO:0006811]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; ion transport [GO:0006811]; transmembrane transport [GO:0055085] identical protein binding [GO:0042802] GO:0005886; GO:0006811; GO:0016021; GO:0042802; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:22874652}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:22874652}. +P11875 SYR_ECOLI Arginine--tRNA ligase (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS) argS b1876 JW1865 argS 64,683 arginyl-tRNA aminoacylation [GO:0006420] cytosol [GO:0005829] cytosol [GO:0005829]; arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524]; arginyl-tRNA aminoacylation [GO:0006420] arginine-tRNA ligase activity [GO:0004814]; ATP binding [GO:0005524] GO:0004814; GO:0005524; GO:0005829; GO:0006420 SUBCELLULAR LOCATION: Cytoplasm. +P69423 TATC_ECOLI Sec-independent protein translocase protein TatC tatC mttB yigU yigV b3839 JW3815 mttB yigU yigV tatC 28,876 intracellular protein transmembrane transport [GO:0065002]; protein transport by the Tat complex [GO:0043953]; response to radiation [GO:0009314] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; TAT protein transport complex [GO:0033281] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; TAT protein transport complex [GO:0033281]; identical protein binding [GO:0042802]; protein transmembrane transporter activity [GO:0008320]; proton motive force dependent protein transmembrane transporter activity [GO:0009977]; intracellular protein transmembrane transport [GO:0065002]; protein transport by the Tat complex [GO:0043953]; response to radiation [GO:0009314] identical protein binding [GO:0042802]; protein transmembrane transporter activity [GO:0008320]; proton motive force dependent protein transmembrane transporter activity [GO:0009977] GO:0005886; GO:0005887; GO:0008320; GO:0009314; GO:0009977; GO:0016020; GO:0033281; GO:0042802; GO:0043953; GO:0065002 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00902, ECO:0000269|PubMed:11591389, ECO:0000269|PubMed:15225613, ECO:0000269|PubMed:20169075}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00902, ECO:0000269|PubMed:11591389, ECO:0000269|PubMed:15225613, ECO:0000269|PubMed:20169075}. Note=Localizes at the cell poles. +P33570 TKT2_ECOLI Transketolase 2 (TK 2) (EC 2.2.1.1) tktB b2465 JW2449 tktB 73,043 pentose-phosphate shunt [GO:0006098] cytosol [GO:0005829] cytosol [GO:0005829]; metal ion binding [GO:0046872]; transketolase activity [GO:0004802]; pentose-phosphate shunt [GO:0006098] metal ion binding [GO:0046872]; transketolase activity [GO:0004802] GO:0004802; GO:0005829; GO:0006098; GO:0046872 +Q47539 TAUC_ECOLI Taurine transport system permease protein TauC tauC ssiC yaiJ b0367 JW0359 ssiC yaiJ tauC 29,812 alkanesulfonate transport [GO:0042918]; cellular response to sulfur starvation [GO:0010438] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; alkanesulfonate transmembrane transporter activity [GO:0042959]; transmembrane transporter activity [GO:0022857]; alkanesulfonate transport [GO:0042918]; cellular response to sulfur starvation [GO:0010438] alkanesulfonate transmembrane transporter activity [GO:0042959]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0010438; GO:0022857; GO:0042918; GO:0042959 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:15919996}. +P37610 TAUD_ECOLI Alpha-ketoglutarate-dependent taurine dioxygenase (EC 1.14.11.17) (2-aminoethanesulfonate dioxygenase) (Sulfate starvation-induced protein 3) (SSI3) tauD ssiD yaiG b0368 JW0360 ssiD yaiG tauD 32,410 protein homotetramerization [GO:0051289]; sulfur compound metabolic process [GO:0006790] cytoplasm [GO:0005737]; taurine dioxygenase complex [GO:1990205] cytoplasm [GO:0005737]; taurine dioxygenase complex [GO:1990205]; 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; ferrous iron binding [GO:0008198]; L-ascorbic acid binding [GO:0031418]; taurine dioxygenase activity [GO:0000908]; protein homotetramerization [GO:0051289]; sulfur compound metabolic process [GO:0006790] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; ferrous iron binding [GO:0008198]; L-ascorbic acid binding [GO:0031418]; taurine dioxygenase activity [GO:0000908] GO:0000908; GO:0005737; GO:0006790; GO:0008198; GO:0016706; GO:0031418; GO:0051289; GO:1990205 +P0AFS5 TQSA_ECOLI AI-2 transport protein TqsA (Transport of quorum-sensing signal protein) tqsA ydgG b1601 JW1593 ydgG tqsA 37,543 autoinducer AI-2 transmembrane transport [GO:1905887]; quorum sensing [GO:0009372]; transmembrane transport [GO:0055085] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; efflux transmembrane transporter activity [GO:0015562]; autoinducer AI-2 transmembrane transport [GO:1905887]; quorum sensing [GO:0009372]; transmembrane transport [GO:0055085] efflux transmembrane transporter activity [GO:0015562] GO:0005887; GO:0009372; GO:0015562; GO:0055085; GO:1905887 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AGF4 XYLE_ECOLI D-xylose-proton symporter (D-xylose transporter) xylE b4031 JW3991 xylE 53,608 D-xylose transmembrane transport [GO:0015753] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; D-xylose:proton symporter activity [GO:0015519]; D-xylose transmembrane transport [GO:0015753] D-xylose:proton symporter activity [GO:0015519] GO:0005886; GO:0005887; GO:0015519; GO:0015753 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:23075985}; Multi-pass membrane protein {ECO:0000269|PubMed:23075985}. +P0AAW5 YBHQ_ECOLI Inner membrane protein YbhQ ybhQ b0791 JW0774 ybhQ 15,465 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A8C1 YBJQ_ECOLI UPF0145 protein YbjQ ybjQ b0866 JW0850 ybjQ 11,437 +P75693 YAHN_ECOLI Uncharacterized membrane protein YahN yahN b0328 JW0320 yahN 24,811 amino acid transport [GO:0006865] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; amino acid transport [GO:0006865] amino acid transmembrane transporter activity [GO:0015171] GO:0005886; GO:0005887; GO:0006865; GO:0015171 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P77286 YDEU_ECOLI Uncharacterized protein YdeU ydeU b1509 JW1502 ydeU 50,539 outer membrane [GO:0019867] outer membrane [GO:0019867] GO:0019867 +P77619 YFEW_ECOLI Putative D-alanyl-D-alanine carboxypeptidase (EC 3.4.16.4) (DD-carboxypeptidase) (DD-CPase) (Penicillin binding protein 4B) yfeW pbp4B b2430 JW5395 pbp4B yfeW 47,752 integral component of membrane [GO:0016021]; intrinsic component of plasma membrane [GO:0031226] integral component of membrane [GO:0016021]; intrinsic component of plasma membrane [GO:0031226]; penicillin binding [GO:0008658]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002] penicillin binding [GO:0008658]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002] GO:0008658; GO:0009002; GO:0016021; GO:0031226 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01034, ECO:0000305|PubMed:16402224}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01034, ECO:0000305|PubMed:16402224}. +Q46840 YGHO_ECOLI Protein YghO yghO b2981 JW5848 yghO 44,674 +P42589 YGJH_ECOLI tRNA-binding protein YgjH ygjH b3074 JW3045 ygjH 12,315 tRNA binding [GO:0000049] tRNA binding [GO:0000049] GO:0000049 +P76196 YDIL_ECOLI Uncharacterized protein YdiL ydiL b1689 JW1679 ydiL 13,929 DNA binding [GO:0003677] DNA binding [GO:0003677] GO:0003677 +P58094 YCIX_ECOLI Uncharacterized protein YciX yciX b4523 JW5198/JW5199 yciX 6,338 +P0ACW2 YDBJ_ECOLI Uncharacterized protein YdbJ ydbJ b4529 JW5215 ydbJ 8,696 +P33340 YEHA_ECOLI Uncharacterized fimbrial-like protein YehA yehA b2108 JW2095 yehA 36,885 cell adhesion involved in single-species biofilm formation [GO:0043709] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion involved in single-species biofilm formation [GO:0043709] GO:0009289; GO:0043709 +P0ADP2 YIGI_ECOLI Uncharacterized protein YigI yigI b3820 JW5588 yigI 17,163 cytosol [GO:0005829] cytosol [GO:0005829]; 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity [GO:0061522] 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity [GO:0061522] GO:0005829; GO:0061522 +P64499 YEBO_ECOLI Uncharacterized protein YebO yebO b1825 JW1814 yebO 10,792 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P0ADK6 YIBA_ECOLI Protein YibA yibA b3594 JW3568 yibA 31,874 cellular response to DNA damage stimulus [GO:0006974]; response to antibiotic [GO:0046677]; response to radiation [GO:0009314] oxidoreductase activity [GO:0016491]; cellular response to DNA damage stimulus [GO:0006974]; response to antibiotic [GO:0046677]; response to radiation [GO:0009314] oxidoreductase activity [GO:0016491] GO:0006974; GO:0009314; GO:0016491; GO:0046677 +P37691 YIBQ_ECOLI Uncharacterized protein YibQ yibQ b3614 JW5645 yibQ 35,353 carbohydrate metabolic process [GO:0005975] catalytic activity [GO:0003824]; carbohydrate metabolic process [GO:0005975] catalytic activity [GO:0003824] GO:0003824; GO:0005975 +A5A628 YJBT_ECOLI Uncharacterized protein YjbT yjbT b4620 yjbT 10,049 +P0DSG8 YHIY_ECOLI Protein YhiY yhiY b4790 yhiY 4,153 +Q79E92 YKGN_ECOLI Putative transposase YkgN ykgN b4505 JW0258 ykgN 12,857 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P39274 YJDJ_ECOLI Uncharacterized protein YjdJ yjdJ b4127 JW4088 yjdJ 10,468 +P75961 YCFZ_ECOLI Inner membrane protein YcfZ ycfZ b1121 JW1107 ycfZ 28,865 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AB49 YCHH_ECOLI Uncharacterized protein YchH ychH b1205 JW1196 ychH 10,486 cellular response to cadmium ion [GO:0071276]; cellular response to hydrogen peroxide [GO:0070301]; single-species biofilm formation on inanimate substrate [GO:0044011] cellular response to cadmium ion [GO:0071276]; cellular response to hydrogen peroxide [GO:0070301]; single-species biofilm formation on inanimate substrate [GO:0044011] GO:0044011; GO:0070301; GO:0071276 +P42913 YRAH_ECOLI Uncharacterized fimbrial-like protein YraH yraH b3142 JW3111 yraH 20,744 cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0007155; GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. +P76170 YNFB_ECOLI UPF0482 protein YnfB ynfB b1583 JW1575 ynfB 12,909 cell outer membrane [GO:0009279] cell outer membrane [GO:0009279] GO:0009279 +C1P613 YQEL_ECOLI Uncharacterized protein YqeL yqeL b4683 JW5455.1 yqeL 3,203 +P77309 YNEJ_ECOLI Uncharacterized HTH-type transcriptional regulator YneJ yneJ b1526 JW1519 yneJ 32,483 regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355 +P0A6X1 HEM1_ECOLI Glutamyl-tRNA reductase (GluTR) (EC 1.2.1.70) hemA b1210 JW1201 hemA 46,307 protoporphyrinogen IX biosynthetic process from glutamate [GO:0019353] glutamyl-tRNA reductase activity [GO:0008883]; identical protein binding [GO:0042802]; NADP binding [GO:0050661]; protoporphyrinogen IX biosynthetic process from glutamate [GO:0019353] glutamyl-tRNA reductase activity [GO:0008883]; identical protein binding [GO:0042802]; NADP binding [GO:0050661] GO:0008883; GO:0019353; GO:0042802; GO:0050661 +P77739 KT3K_ECOLI Probable ketoamine kinase YniA (EC 2.7.1.-) yniA b1725 JW1714 yniA 32,459 ATP binding [GO:0005524]; kinase activity [GO:0016301] ATP binding [GO:0005524]; kinase activity [GO:0016301] GO:0005524; GO:0016301 +P43341 LPXH_ECOLI UDP-2,3-diacylglucosamine hydrolase (EC 3.6.1.54) (UDP-2,3-diacylglucosamine diphosphatase) (UDP-2,3-diacylglucosamine pyrophosphatase) lpxH ybbF b0524 JW0513 ybbF lpxH 26,894 lipid A biosynthetic process [GO:0009245] cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of plasma membrane [GO:0019897] cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of plasma membrane [GO:0019897]; manganese ion binding [GO:0030145]; UDP-2,3-diacylglucosamine hydrolase activity [GO:0008758]; lipid A biosynthetic process [GO:0009245] manganese ion binding [GO:0030145]; UDP-2,3-diacylglucosamine hydrolase activity [GO:0008758] GO:0005737; GO:0008758; GO:0009245; GO:0019897; GO:0030145; GO:0031234 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:12000770}; Peripheral membrane protein {ECO:0000269|PubMed:12000770}; Cytoplasmic side {ECO:0000305|PubMed:12000770}. Cytoplasm {ECO:0000269|PubMed:12000770}. +P77257 LSRA_ECOLI Autoinducer 2 import ATP-binding protein LsrA (AI-2 import ATP-binding protein LsrA) (EC 7.6.2.13) (EGO10A) lsrA ego ydeX b1513 JW1506 ego ydeX lsrA 55,821 autoinducer AI-2 transmembrane transport [GO:1905887] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; autoinducer AI-2 transmembrane transport [GO:1905887] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0016021; GO:0042626; GO:1905887 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P25744 MDTG_ECOLI Multidrug resistance protein MdtG mdtG yceE b1053 JW1040 yceE mdtG 43,867 response to antibiotic [GO:0046677]; response to paraquat [GO:1901562]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; transmembrane transporter activity [GO:0022857]; response to antibiotic [GO:0046677]; response to paraquat [GO:1901562]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] transmembrane transporter activity [GO:0022857] GO:0005887; GO:0022857; GO:0046677; GO:1901562; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P76398 MDTB_ECOLI Multidrug resistance protein MdtB (Multidrug transporter MdtB) mdtB yegN b2075 JW2060 yegN mdtB 112,078 bile acid and bile salt transport [GO:0015721]; proton transmembrane transport [GO:1902600]; xenobiotic transport [GO:0042908] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; bile acid transmembrane transporter activity [GO:0015125]; xenobiotic transmembrane transporter activity [GO:0042910]; bile acid and bile salt transport [GO:0015721]; proton transmembrane transport [GO:1902600]; xenobiotic transport [GO:0042908] bile acid transmembrane transporter activity [GO:0015125]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0005887; GO:0015125; GO:0015721; GO:0042908; GO:0042910; GO:1902600 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01423}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01423}. +P77569 MHPR_ECOLI DNA-binding transcriptional activator MhpR (mhp operon transcriptional activator) mhpR b0346 JW0337 mhpR 31,322 aromatic compound catabolic process [GO:0019439]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; aromatic compound catabolic process [GO:0019439]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0019439; GO:0045892 +P0AEZ3 MIND_ECOLI Septum site-determining protein MinD (Cell division inhibitor MinD) minD b1175 JW1164 minD 29,614 cell division [GO:0051301]; chromosome segregation [GO:0007059]; division septum assembly [GO:0000917]; negative regulation of cell division [GO:0051782] cell pole [GO:0060187]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; intrinsic component of plasma membrane [GO:0031226]; plasma membrane [GO:0005886] cell pole [GO:0060187]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; intrinsic component of plasma membrane [GO:0031226]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; identical protein binding [GO:0042802]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; division septum assembly [GO:0000917]; negative regulation of cell division [GO:0051782] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; identical protein binding [GO:0042802] GO:0000917; GO:0005524; GO:0005829; GO:0005886; GO:0007059; GO:0009898; GO:0016887; GO:0031226; GO:0042802; GO:0051301; GO:0051782; GO:0060187 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. +P0A8T1 PRMA_ECOLI Ribosomal protein L11 methyltransferase (L11 Mtase) (EC 2.1.1.-) prmA yhdI b3259 JW3227 yhdI prmA 31,877 N-terminal peptidyl-alanine trimethylation [GO:0018012]; peptidyl-lysine trimethylation [GO:0018023] cytosol [GO:0005829] cytosol [GO:0005829]; protein-lysine N-methyltransferase activity [GO:0016279]; N-terminal peptidyl-alanine trimethylation [GO:0018012]; peptidyl-lysine trimethylation [GO:0018023] protein-lysine N-methyltransferase activity [GO:0016279] GO:0005829; GO:0016279; GO:0018012; GO:0018023 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00735, ECO:0000305}. +P10907 UGPC_ECOLI sn-glycerol-3-phosphate import ATP-binding protein UgpC (EC 7.6.2.10) ugpC b3450 JW3415 ugpC 39,524 carbohydrate transport [GO:0008643]; glycerol-3-phosphate transmembrane transport [GO:0015794]; glycerophosphodiester transmembrane transport [GO:0001407] ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052] ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; ABC-type glycerol-3-phosphate transporter activity [GO:0015430]; ATP binding [GO:0005524]; glycerol-3-phosphate transmembrane transporter activity [GO:0015169]; glycerophosphodiester transmembrane transporter activity [GO:0001406]; carbohydrate transport [GO:0008643]; glycerol-3-phosphate transmembrane transport [GO:0015794]; glycerophosphodiester transmembrane transport [GO:0001407] ABC-type glycerol-3-phosphate transporter activity [GO:0015430]; ATP binding [GO:0005524]; glycerol-3-phosphate transmembrane transporter activity [GO:0015169]; glycerophosphodiester transmembrane transporter activity [GO:0001406] GO:0001406; GO:0001407; GO:0005524; GO:0008643; GO:0015169; GO:0015430; GO:0015794; GO:0055052 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. +P43672 UUP_ECOLI ATP-binding protein Uup (EC 3.6.1.-) uup ycbH ycbI b0949 JW0932 ycbH ycbI uup 72,067 DNA repair [GO:0006281]; regulation of transposon integration [GO:0070894]; response to radiation [GO:0009314] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; DNA binding [GO:0003677]; ribosome binding [GO:0043022]; DNA repair [GO:0006281]; regulation of transposon integration [GO:0070894]; response to radiation [GO:0009314] ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; ribosome binding [GO:0043022] GO:0003677; GO:0005524; GO:0005737; GO:0005886; GO:0006281; GO:0009314; GO:0016887; GO:0042626; GO:0043022; GO:0070894 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00848, ECO:0000269|PubMed:16407313, ECO:0000269|Ref.10}. Note=Associates with ribosomes. {ECO:0000255|HAMAP-Rule:MF_00848, ECO:0000269|Ref.10}. +P37344 PSPF_ECOLI Psp operon transcriptional activator (Phage shock protein F) pspF ycjB b1303 JW1296 ycjB pspF 36,986 negative regulation of transcription, DNA-templated [GO:0045892]; phosphorelay signal transduction system [GO:0000160]; positive regulation of transcription, DNA-templated [GO:0045893] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565]; transcription factor binding [GO:0008134]; negative regulation of transcription, DNA-templated [GO:0045892]; phosphorelay signal transduction system [GO:0000160]; positive regulation of transcription, DNA-templated [GO:0045893] ATP binding [GO:0005524]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565]; transcription factor binding [GO:0008134] GO:0000160; GO:0003677; GO:0005524; GO:0005737; GO:0008134; GO:0042802; GO:0043565; GO:0045892; GO:0045893 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +Q46890 OTNC_ECOLI 3-oxo-tetronate 4-phosphate decarboxylase (EC 4.1.1.104) otnC ygbL b2738 JW2708 ygbL otnC 23,222 pentose catabolic process [GO:0019323] cytosol [GO:0005829] cytosol [GO:0005829]; aldehyde-lyase activity [GO:0016832]; metal ion binding [GO:0046872]; pentose catabolic process [GO:0019323] aldehyde-lyase activity [GO:0016832]; metal ion binding [GO:0046872] GO:0005829; GO:0016832; GO:0019323; GO:0046872 +P20083 PARE_ECOLI DNA topoisomerase 4 subunit B (EC 5.6.2.2) (Topoisomerase IV subunit B) parE nfxD b3030 JW2998 nfxD parE 70,244 chromosome organization [GO:0051276]; DNA topological change [GO:0006265]; plasmid partitioning [GO:0030541]; response to antibiotic [GO:0046677]; sister chromatid cohesion [GO:0007062] chromosome [GO:0005694]; cytosol [GO:0005829] chromosome [GO:0005694]; cytosol [GO:0005829]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; metal ion binding [GO:0046872]; chromosome organization [GO:0051276]; DNA topological change [GO:0006265]; plasmid partitioning [GO:0030541]; response to antibiotic [GO:0046677]; sister chromatid cohesion [GO:0007062] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; metal ion binding [GO:0046872] GO:0003677; GO:0003918; GO:0005524; GO:0005694; GO:0005829; GO:0006265; GO:0007062; GO:0030541; GO:0046677; GO:0046872; GO:0051276 +P0A9L8 P5CR_ECOLI Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2) (PCA reductase) proC b0386 JW0377 proC 28,145 L-proline biosynthetic process [GO:0055129] cytosol [GO:0005829] cytosol [GO:0005829]; identical protein binding [GO:0042802]; pyrroline-5-carboxylate reductase activity [GO:0004735]; L-proline biosynthetic process [GO:0055129] identical protein binding [GO:0042802]; pyrroline-5-carboxylate reductase activity [GO:0004735] GO:0004735; GO:0005829; GO:0042802; GO:0055129 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01925, ECO:0000269|PubMed:6296787}. +P76446 PDEN_ECOLI Probable cyclic di-GMP phosphodiesterase PdeN (EC 3.1.4.52) pdeN rtn b2176 JW2164 rtn pdeN 58,588 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cyclic-guanylate-specific phosphodiesterase activity [GO:0071111] cyclic-guanylate-specific phosphodiesterase activity [GO:0071111] GO:0005886; GO:0016021; GO:0071111 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P0C7L2 PAAJ_ECOLI 3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase (EC 2.3.1.174) (EC 2.3.1.223) paaJ paaE ydbW b1397 JW1392 paaE ydbW paaJ 42,277 3,4-dihydroxybenzoate catabolic process [GO:0019619]; cellular response to DNA damage stimulus [GO:0006974]; fatty acid beta-oxidation [GO:0006635]; phenylacetate catabolic process [GO:0010124] 3-oxoadipyl-CoA thiolase activity [GO:0033812]; acetyl-CoA C-acyltransferase activity [GO:0003988]; transferase activity [GO:0016740]; 3,4-dihydroxybenzoate catabolic process [GO:0019619]; cellular response to DNA damage stimulus [GO:0006974]; fatty acid beta-oxidation [GO:0006635]; phenylacetate catabolic process [GO:0010124] 3-oxoadipyl-CoA thiolase activity [GO:0033812]; acetyl-CoA C-acyltransferase activity [GO:0003988]; transferase activity [GO:0016740] GO:0003988; GO:0006635; GO:0006974; GO:0010124; GO:0016740; GO:0019619; GO:0033812 +P76083 PAAH_ECOLI 3-hydroxyadipyl-CoA dehydrogenase (EC 1.1.1.-) paaH ydbU b1395 JW1390 ydbU paaH 51,733 fatty acid metabolic process [GO:0006631]; phenylacetate catabolic process [GO:0010124] 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; 3-hydroxybutyryl-CoA dehydrogenase activity [GO:0008691]; NAD+ binding [GO:0070403]; fatty acid metabolic process [GO:0006631]; phenylacetate catabolic process [GO:0010124] 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; 3-hydroxybutyryl-CoA dehydrogenase activity [GO:0008691]; NAD+ binding [GO:0070403] GO:0003857; GO:0006631; GO:0008691; GO:0010124; GO:0070403 +P0AFK9 POTD_ECOLI Spermidine/putrescine-binding periplasmic protein (SPBP) potD b1123 JW1109 potD 38,867 putrescine transport [GO:0015847]; spermidine transport [GO:0015848] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; putrescine binding [GO:0019810]; spermidine binding [GO:0019809]; putrescine transport [GO:0015847]; spermidine transport [GO:0015848] putrescine binding [GO:0019810]; spermidine binding [GO:0019809] GO:0015847; GO:0015848; GO:0019809; GO:0019810; GO:0030288 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:1939142}. +P0AFL3 PPIA_ECOLI Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Rotamase A) ppiA rot rotA b3363 JW3326 rot rotA ppiA 20,431 protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] GO:0000413; GO:0003755; GO:0006457; GO:0030288; GO:0042597 SUBCELLULAR LOCATION: Periplasm. +P69411 RCSF_ECOLI Outer membrane lipoprotein RcsF rcsF b0196 JW0192 rcsF 14,163 cellular response to cell envelope stress [GO:0036460]; intracellular signal transduction [GO:0035556]; positive regulation of phosphorelay signal transduction system [GO:0070299] anchored component of periplasmic side of cell outer membrane [GO:0036406]; cell outer membrane [GO:0009279]; external side of cell outer membrane [GO:0031240]; periplasmic side of cell outer membrane [GO:0031241] anchored component of periplasmic side of cell outer membrane [GO:0036406]; cell outer membrane [GO:0009279]; external side of cell outer membrane [GO:0031240]; periplasmic side of cell outer membrane [GO:0031241]; cellular response to cell envelope stress [GO:0036460]; intracellular signal transduction [GO:0035556]; positive regulation of phosphorelay signal transduction system [GO:0070299] GO:0009279; GO:0031240; GO:0031241; GO:0035556; GO:0036406; GO:0036460; GO:0070299 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_00976, ECO:0000269|PubMed:16740933, ECO:0000269|PubMed:23813676}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_00976, ECO:0000269|PubMed:16740933, ECO:0000269|PubMed:23813676}; Periplasmic side {ECO:0000255|HAMAP-Rule:MF_00976, ECO:0000269|PubMed:16740933, ECO:0000269|PubMed:23813676}. +P15033 RACC_ECOLI Protein RacC racC b1351 JW1345 racC 10,016 +P16916 RHSA_ECOLI Protein RhsA rhsA b3593 JW3566 rhsA 156,321 +P69924 RIR2_ECOLI Ribonucleoside-diphosphate reductase 1 subunit beta (EC 1.17.4.1) (Protein B2) (Protein R2) (Ribonucleotide reductase 1) nrdB ftsB b2235 JW2229 ftsB nrdB 43,517 deoxyribonucleotide biosynthetic process [GO:0009263]; DNA replication [GO:0006260]; nucleobase-containing small molecule interconversion [GO:0015949] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribonucleoside-diphosphate reductase complex [GO:0005971] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribonucleoside-diphosphate reductase complex [GO:0005971]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA replication [GO:0006260]; nucleobase-containing small molecule interconversion [GO:0015949] identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748] GO:0004748; GO:0005506; GO:0005737; GO:0005829; GO:0005971; GO:0006260; GO:0009263; GO:0015949; GO:0042802 +P02413 RL15_ECOLI 50S ribosomal protein L15 (Large ribosomal subunit protein uL15) rplO b3301 JW3263 rplO 14,980 translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] cytosolic large ribosomal subunit [GO:0022625]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GO:0003735; GO:0006412; GO:0019843; GO:0022625 +P0A7Y8 RNPA_ECOLI Ribonuclease P protein component (RNase P protein) (RNaseP protein) (EC 3.1.26.5) (Protein C5) rnpA b3704 JW3681 rnpA 13,789 RNA processing [GO:0006396]; tRNA 3'-trailer cleavage, endonucleolytic [GO:0034414]; tRNA 5'-leader removal [GO:0001682] ribonuclease P complex [GO:0030677] ribonuclease P complex [GO:0030677]; 3'-tRNA processing endoribonuclease activity [GO:0042781]; ribonuclease P activity [GO:0004526]; tRNA binding [GO:0000049]; RNA processing [GO:0006396]; tRNA 3'-trailer cleavage, endonucleolytic [GO:0034414]; tRNA 5'-leader removal [GO:0001682] 3'-tRNA processing endoribonuclease activity [GO:0042781]; ribonuclease P activity [GO:0004526]; tRNA binding [GO:0000049] GO:0000049; GO:0001682; GO:0004526; GO:0006396; GO:0030677; GO:0034414; GO:0042781 +P19934 TOLA_ECOLI Tol-Pal system protein TolA tolA cim excC lky b0739 JW0729 cim excC lky tolA 43,157 bacteriocin transport [GO:0043213]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to bacteriocin [GO:0071237]; protein import [GO:0017038]; protein transport [GO:0015031]; viral entry into host cell [GO:0046718] cell division site [GO:0032153]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cell division site [GO:0032153]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; disordered domain specific binding [GO:0097718]; protein domain specific binding [GO:0019904]; toxin transmembrane transporter activity [GO:0019534]; virion binding [GO:0046790]; bacteriocin transport [GO:0043213]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to bacteriocin [GO:0071237]; protein import [GO:0017038]; protein transport [GO:0015031]; viral entry into host cell [GO:0046718] disordered domain specific binding [GO:0097718]; protein domain specific binding [GO:0019904]; toxin transmembrane transporter activity [GO:0019534]; virion binding [GO:0046790] GO:0005886; GO:0005887; GO:0007049; GO:0015031; GO:0016021; GO:0017038; GO:0019534; GO:0019904; GO:0032153; GO:0043213; GO:0046718; GO:0046790; GO:0051301; GO:0071237; GO:0097718 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:2068069, ECO:0000269|PubMed:2687247}; Single-pass membrane protein {ECO:0000269|PubMed:2687247}. Note=Accumulates at cell constriction sites. Recruitment to the division site is dependent on FtsN activity. {ECO:0000269|PubMed:17233825}. +P0AG00 WZZE_ECOLI ECA polysaccharide chain length modulation protein wzzE wzz yifC b3785 JW5601 wzz yifC wzzE 39,489 enterobacterial common antigen biosynthetic process [GO:0009246]; lipopolysaccharide biosynthetic process [GO:0009103] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; protein tyrosine kinase activity [GO:0004713]; enterobacterial common antigen biosynthetic process [GO:0009246]; lipopolysaccharide biosynthetic process [GO:0009103] protein tyrosine kinase activity [GO:0004713] GO:0004713; GO:0005886; GO:0005887; GO:0009103; GO:0009246 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02025, ECO:0000305}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02025}. +P45562 XAPB_ECOLI Xanthosine permease (Xanthosine transporter) xapB b2406 JW2397 xapB 46,140 nucleobase-containing small molecule metabolic process [GO:0055086]; nucleoside transport [GO:0015858]; organic substance transport [GO:0071702] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cytidine transmembrane transporter activity [GO:0015212]; nucleoside transmembrane transporter activity [GO:0005337]; uridine transmembrane transporter activity [GO:0015213]; xanthosine transmembrane transporter activity [GO:0015553]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleoside transport [GO:0015858]; organic substance transport [GO:0071702] cytidine transmembrane transporter activity [GO:0015212]; nucleoside transmembrane transporter activity [GO:0005337]; uridine transmembrane transporter activity [GO:0015213]; xanthosine transmembrane transporter activity [GO:0015553] GO:0005337; GO:0005886; GO:0005887; GO:0015212; GO:0015213; GO:0015553; GO:0015858; GO:0016020; GO:0016021; GO:0055086; GO:0071702 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:11466294, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:7559336}; Multi-pass membrane protein {ECO:0000255}. +P27833 WECE_ECOLI dTDP-4-amino-4,6-dideoxygalactose transaminase (EC 2.6.1.59) wecE rffA yifI b3791 JW3765 rffA yifI wecE 41,901 enterobacterial common antigen biosynthetic process [GO:0009246]; polysaccharide biosynthetic process [GO:0000271] dTDP-4-amino-4,6-dideoxygalactose transaminase activity [GO:0019180]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]; enterobacterial common antigen biosynthetic process [GO:0009246]; polysaccharide biosynthetic process [GO:0000271] dTDP-4-amino-4,6-dideoxygalactose transaminase activity [GO:0019180]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] GO:0000271; GO:0008483; GO:0009246; GO:0019180; GO:0030170; GO:0042802 +P56258 WECF_ECOLI TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase (EC 2.4.1.325) (4-alpha-L-fucosyltransferase) (TDP-Fuc4NAc:lipid II Fuc4NAc transferase) (Fuc4NAc transferase) wecF rffT yifM b4481 JW5596 rffT yifM wecF 40,640 enterobacterial common antigen biosynthetic process [GO:0009246] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; 4-acetamido-4,6-dideoxy-D-galactose transferase activity [GO:0102031]; fucosyltransferase activity [GO:0008417]; enterobacterial common antigen biosynthetic process [GO:0009246] 4-acetamido-4,6-dideoxy-D-galactose transferase activity [GO:0102031]; fucosyltransferase activity [GO:0008417] GO:0005886; GO:0008417; GO:0009246; GO:0102031 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P37645 YHJG_ECOLI AsmA family protein YhjG yhjG yhjF b3524 JW3492 yhjF yhjG 74,457 regulation of protein targeting to membrane [GO:0090313] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; regulation of protein targeting to membrane [GO:0090313] GO:0005886; GO:0016021; GO:0090313 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P39407 YJJU_ECOLI Uncharacterized protein YjjU (EC 3.1.1.-) yjjU b4377 JW4340 yjjU 39,832 cellular response to DNA damage stimulus [GO:0006974]; lipid catabolic process [GO:0016042] hydrolase activity [GO:0016787]; cellular response to DNA damage stimulus [GO:0006974]; lipid catabolic process [GO:0016042] hydrolase activity [GO:0016787] GO:0006974; GO:0016042; GO:0016787 +P0AGM0 YHHT_ECOLI Putative transport protein YhhT yhhT b3474 JW5680 yhhT 38,522 transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transport [GO:0055085] GO:0005886; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AF86 YJFY_ECOLI Uncharacterized protein YjfY yjfY b4199 JW4157 yjfY 10,149 periplasmic space [GO:0042597] periplasmic space [GO:0042597] GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P77315 YPHD_ECOLI Probable ABC transporter permease protein YphD yphD b2546 JW2530 yphD 34,483 integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0ADR0 YQAA_ECOLI Inner membrane protein YqaA yqaA b2689 JW2664 yqaA 15,590 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76539 YPEA_ECOLI Acetyltransferase YpeA (EC 2.3.1.-) ypeA b2434 JW2427 ypeA 16,312 N-acetyltransferase activity [GO:0008080] N-acetyltransferase activity [GO:0008080] GO:0008080 +P75757 ZITB_ECOLI Zinc transporter ZitB zitB ybgR b0752 JW0735 ybgR zitB 34,678 zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; zinc ion transmembrane transporter activity [GO:0005385]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829] zinc ion transmembrane transporter activity [GO:0005385] GO:0005385; GO:0005886; GO:0006829; GO:0016021; GO:0071577 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0DSH6 YSDE_ECOLI Protein YsdE ysdE b4798 ysdE 2,827 +P76157 YNFN_ECOLI Uncharacterized protein YnfN ynfN b1551 JW5254 ynfN 5,639 +P64517 YODC_ECOLI Uncharacterized protein YodC yodC b1957 JW1940 yodC 6,678 +P76524 YPDF_ECOLI Aminopeptidase YpdF (EC 3.4.11.-) ypdF b2385 JW2382 ypdF 39,624 proteolysis [GO:0006508] aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; transition metal ion binding [GO:0046914]; proteolysis [GO:0006508] aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; transition metal ion binding [GO:0046914] GO:0004177; GO:0006508; GO:0046914; GO:0070006 +P0ACS5 ZNTR_ECOLI HTH-type transcriptional regulator ZntR (Zn(II)-responsive regulator of zntA) zntR yhdM b3292 JW3254 yhdM zntR 16,179 positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270] GO:0000986; GO:0001216; GO:0003700; GO:0006351; GO:0008270; GO:0045893 +Q2M7M3 YSAB_ECOLI Uncharacterized lipoprotein YsaB ysaB b4553 JW3532 ysaB 11,336 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P0DUM3 TIMP_ECOLI Putative toxic protein TimP timP b4812 timP 4,477 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:P0DUM2}; Single-pass membrane protein {ECO:0000250|UniProtKB:P0DUM2}. Note=The signal sequence is not cleaved and anchors the protein in the cell inner membrane. {ECO:0000250|UniProtKB:P0DUM2}. +P37774 TCYN_ECOLI L-cystine transport system ATP-binding protein TcyN (EC 7.4.2.12) tcyN yecC b1917 JW1902 yecC tcyN 27,677 L-cystine transport [GO:0015811] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; L-cystine transmembrane transporter activity [GO:0015184]; L-cystine transport [GO:0015811] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; L-cystine transmembrane transporter activity [GO:0015184] GO:0005524; GO:0005886; GO:0015184; GO:0015811; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P11868 TDCD_ECOLI Propionate kinase (EC 2.7.2.15) tdcD yhaA b3115 JW5806 yhaA tdcD 43,384 anaerobic amino acid catabolic process [GO:0019665]; L-threonine catabolic process to propionate [GO:0070689]; threonine catabolic process [GO:0006567] acetate kinase activity [GO:0008776]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; propionate kinase activity [GO:0008980]; anaerobic amino acid catabolic process [GO:0019665]; L-threonine catabolic process to propionate [GO:0070689]; threonine catabolic process [GO:0006567] acetate kinase activity [GO:0008776]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; propionate kinase activity [GO:0008980] GO:0005524; GO:0006567; GO:0008776; GO:0008980; GO:0019665; GO:0046872; GO:0070689 +P36673 TRER_ECOLI HTH-type transcriptional regulator TreR (Trehalose operon repressor) treR b4241 JW4200 treR 34,531 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; trehalose metabolic process [GO:0005991] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; trehalose metabolic process [GO:0005991] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0005991; GO:0006355; GO:0045892 +P25535 UBII_ECOLI 2-octaprenylphenol hydroxylase (EC 1.14.13.240) (2-polyprenylphenol 6-hydroxylase) ubiI visC b2906 JW2874 visC ubiI 44,245 ubiquinone biosynthetic process [GO:0006744] cytoplasm [GO:0005737]; ubiquinone biosynthesis complex [GO:0110142] cytoplasm [GO:0005737]; ubiquinone biosynthesis complex [GO:0110142]; 2-octaprenylphenol hydroxylase activity [GO:0019168]; FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; ubiquinone biosynthetic process [GO:0006744] 2-octaprenylphenol hydroxylase activity [GO:0019168]; FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709] GO:0005737; GO:0006744; GO:0016491; GO:0016709; GO:0019168; GO:0071949; GO:0110142 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30686758}. +P03018 UVRD_ECOLI DNA helicase II (EC 3.6.4.12) uvrD mutU pdeB rad recL b3813 JW3786 mutU pdeB rad recL uvrD 81,990 DNA duplex unwinding [GO:0032508]; DNA unwinding involved in DNA replication [GO:0006268]; mismatch repair [GO:0006298]; nucleotide-excision repair [GO:0006289]; recombinational repair [GO:0000725]; replication fork processing [GO:0031297]; response to radiation [GO:0009314]; rolling circle DNA replication [GO:0070581]; SOS response [GO:0009432] cytosol [GO:0005829]; DNA helicase complex [GO:0033202] cytosol [GO:0005829]; DNA helicase complex [GO:0033202]; 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]; single-stranded DNA helicase activity [GO:0017116]; DNA duplex unwinding [GO:0032508]; DNA unwinding involved in DNA replication [GO:0006268]; mismatch repair [GO:0006298]; nucleotide-excision repair [GO:0006289]; recombinational repair [GO:0000725]; replication fork processing [GO:0031297]; response to radiation [GO:0009314]; rolling circle DNA replication [GO:0070581]; SOS response [GO:0009432] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]; single-stranded DNA helicase activity [GO:0017116] GO:0000725; GO:0003677; GO:0003678; GO:0005524; GO:0005829; GO:0006268; GO:0006289; GO:0006298; GO:0009314; GO:0009432; GO:0015616; GO:0017116; GO:0031297; GO:0032508; GO:0033202; GO:0043138; GO:0070581 +P75688 Y309_ECOLI Putative uncharacterized protein b0309 b0309 7,854 +P0A9U1 YBHF_ECOLI Probable multidrug ABC transporter ATP-binding protein YbhF ybhF b0794 JW5104 ybhF 63,132 xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; efflux transmembrane transporter activity [GO:0015562]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; efflux transmembrane transporter activity [GO:0015562] GO:0005524; GO:0005886; GO:0015562; GO:0042626; GO:1990961 +P22525 YCBB_ECOLI Probable L,D-transpeptidase YcbB (EC 2.-.-.-) ycbB b0925 JW0908 ycbB 67,812 cellular response to cell envelope stress [GO:0036460]; cellular response to DNA damage stimulus [GO:0006974]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan-protein cross-linking [GO:0018104]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] integral component of membrane [GO:0016021] integral component of membrane [GO:0016021]; carboxypeptidase activity [GO:0004180]; cysteine-type carboxypeptidase activity [GO:0016807]; peptidoglycan L,D-transpeptidase activity [GO:0071972]; transferase activity, transferring glycosyl groups [GO:0016757]; cell wall organization [GO:0071555]; cellular response to cell envelope stress [GO:0036460]; cellular response to DNA damage stimulus [GO:0006974]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan-protein cross-linking [GO:0018104]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] carboxypeptidase activity [GO:0004180]; cysteine-type carboxypeptidase activity [GO:0016807]; peptidoglycan L,D-transpeptidase activity [GO:0071972]; transferase activity, transferring glycosyl groups [GO:0016757] GO:0004180; GO:0006974; GO:0008360; GO:0009252; GO:0016021; GO:0016757; GO:0016807; GO:0018104; GO:0036460; GO:0046677; GO:0071555; GO:0071972 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P77736 YAHD_ECOLI Putative ankyrin repeat protein YahD yahD b0318 JW0310 yahD 21,687 response to radiation [GO:0009314] response to radiation [GO:0009314] GO:0009314 +P0A8U2 YAFD_ECOLI UPF0294 protein YafD yafD b0209 JW5017 yafD 29,992 cytoplasm [GO:0005737] cytoplasm [GO:0005737] GO:0005737 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P28916 YBFD_ECOLI H repeat-associated putative transposase YbfD (ORF-H3) ybfD b0706 JW0696 ybfD 28,865 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P77368 YBCL_ECOLI UPF0098 protein YbcL ybcL b0545 JW0533 ybcL 19,476 negative regulation of catalytic activity [GO:0043086] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; negative regulation of catalytic activity [GO:0043086] GO:0030288; GO:0043086 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:11439028}. +P0A8B2 YFCN_ECOLI UPF0115 protein YfcN yfcN b2331 JW2328 yfcN 21,013 +P46142 YGGM_ECOLI Uncharacterized protein YggM yggM b2956 JW2923 yggM 38,459 +P76573 YFGI_ECOLI Uncharacterized protein YfgI yfgI b2506 JW2490 yfgI 20,230 cellular response to DNA damage stimulus [GO:0006974] cellular response to DNA damage stimulus [GO:0006974] GO:0006974 +P52102 YFHL_ECOLI Ferredoxin YfhL (EcFd) yfhL b2562 JW2546 yfhL 9,791 tRNA wobble base modification [GO:0002097] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; tRNA wobble base modification [GO:0002097] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0002097; GO:0005737; GO:0046872; GO:0051539 +P0ADT5 YGIC_ECOLI Putative acid--amine ligase YgiC (EC 6.3.1.-) ygiC b3038 JW3006 ygiC 45,026 ATP binding [GO:0005524]; ligase activity [GO:0016874]; metal ion binding [GO:0046872] ATP binding [GO:0005524]; ligase activity [GO:0016874]; metal ion binding [GO:0046872] GO:0005524; GO:0016874; GO:0046872 +P76538 YFEZ_ECOLI Inner membrane protein YfeZ yfeZ b2433 JW2426 yfeZ 17,168 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P37766 YDIF_ECOLI Acetate CoA-transferase YdiF (EC 2.8.3.8) (Short-chain acyl-CoA:acetate CoA-transferase) ydiF b1694 JW1684 ydiF 57,562 ketone body catabolic process [GO:0046952]; protein homotetramerization [GO:0051289]; short-chain fatty acid metabolic process [GO:0046459] acetate CoA-transferase activity [GO:0008775]; ketone body catabolic process [GO:0046952]; protein homotetramerization [GO:0051289]; short-chain fatty acid metabolic process [GO:0046459] acetate CoA-transferase activity [GO:0008775] GO:0008775; GO:0046459; GO:0046952; GO:0051289 +P76369 YEEY_ECOLI Uncharacterized HTH-type transcriptional regulator YeeY yeeY b2015 JW5834 yeeY 34,169 regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355 +P42591 YGJJ_ECOLI Uncharacterized protein YgjJ ygjJ b3079 JW3050 ygjJ 40,099 +P77156 YDCU_ECOLI Inner membrane ABC transporter permease protein YdcU ydcU b1442 JW1437 ydcU 34,360 transmembrane transport [GO:0055085] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; transmembrane transport [GO:0055085] GO:0005887; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P58034 YMGF_ECOLI Inner membrane protein YmgF ymgF b4520 JW1156 ymgF 8,255 cell cycle [GO:0007049]; cell division [GO:0051301] division septum [GO:0000935]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] division septum [GO:0000935]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cell cycle [GO:0007049]; cell division [GO:0051301] GO:0000935; GO:0005886; GO:0007049; GO:0016021; GO:0051301 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:18978050}; Multi-pass membrane protein {ECO:0000269|PubMed:18978050}. Note=Localizes to the division septum. Localization requires FtsZ, FtsA, FTsQ and FtsN. +P75979 YMFR_ECOLI Uncharacterized protein YmfR ymfR b1150 JW1136 ymfR 6,381 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P25907 YDBD_ECOLI Uncharacterized protein YdbD ydbD b1407 JW5221 ydbD 86,716 +P0ADI7 YECD_ECOLI Isochorismatase family protein YecD (EC 3.-.-.-) yecD b1867 JW5307 yecD 20,452 cytosol [GO:0005829] cytosol [GO:0005829]; hydrolase activity [GO:0016787] hydrolase activity [GO:0016787] GO:0005829; GO:0016787 +P11286 YIAB_ECOLI Inner membrane protein YiaB yiaB b3563 JW5654 yiaB 12,555 cellular response to DNA damage stimulus [GO:0006974] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cellular response to DNA damage stimulus [GO:0006974] GO:0005886; GO:0005887; GO:0006974 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0DPO1 YMIC_ECOLI Protein YmiC ymiC b4741 ymiC 3,823 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. +P39369 YJHR_ECOLI Putative uncharacterized protein YjhR yjhR b4308 JW4271 yjhR 37,997 hydrolase activity [GO:0016787] hydrolase activity [GO:0016787] GO:0016787 +Q2EEU2 YJHX_ECOLI UPF0386 protein YjhX yjhX b4566 JW5968 yjhX 9,734 regulation of isomerase activity [GO:0010911] DNA topoisomerase binding [GO:0044547]; regulation of isomerase activity [GO:0010911] DNA topoisomerase binding [GO:0044547] GO:0010911; GO:0044547 +P37665 YIAD_ECOLI Probable lipoprotein YiaD yiaD b3552 JW5657 yiaD 22,197 cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0009279; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell outer membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P37682 YIAU_ECOLI Uncharacterized HTH-type transcriptional regulator YiaU yiaU b3585 JW3557 yiaU 37,274 regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700] GO:0000986; GO:0003700; GO:0005829; GO:0006355 +C1P621 YJEV_ECOLI Uncharacterized protein YjeV yjeV b4670 JW5740.1 yjeV 2,056 +P37629 YHIL_ECOLI Putative uncharacterized protein YhiL yhiL b4660 JW3457 b3489 b3490 yhiL 61,576 +P64526 YEEW_ECOLI Protein YeeW yeeW b2006 JW1988 yeeW 6,959 +P37643 YHJE_ECOLI Inner membrane metabolite transport protein YhjE yhjE b3523 JW3491 yhjE 47,208 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76221 YDJZ_ECOLI TVP38/TMEM64 family inner membrane protein YdjZ ydjZ b1752 JW1741 ydjZ 26,160 integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] GO:0005886; GO:0016020; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +C1P5Z8 YKGR_ECOLI Uncharacterized membrane protein YkgR ykgR b4671 JW5035.1 ykgR 3,999 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:21778229}; Single-pass membrane protein {ECO:0000305|PubMed:21778229}. +P76275 YEBW_ECOLI Uncharacterized protein YebW yebW b1837 JW5303 yebW 7,315 +P0DSG2 YQGG_ECOLI Protein YqgG yqgG b4784 yqgG 5,220 +P39317 YTFI_ECOLI Uncharacterized protein YtfI ytfI b4215 JW5748 ytfI 35,935 +A5A630 YTCA_ECOLI Uncharacterized protein YtcA ytcA b4622 ytcA 10,257 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P45465 YRAN_ECOLI UPF0102 protein YraN yraN b3148 JW3117 yraN 14,798 nuclease activity [GO:0004518]; nucleic acid binding [GO:0003676] nuclease activity [GO:0004518]; nucleic acid binding [GO:0003676] GO:0003676; GO:0004518 +P77475 YQAB_ECOLI Fructose-1-phosphate phosphatase YqaB (EC 3.1.3.-) (Fructose-1-phosphatase) yqaB b2690 JW2665 yqaB 20,780 beta-phosphoglucomutase activity [GO:0008801]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; sugar-phosphatase activity [GO:0050308] beta-phosphoglucomutase activity [GO:0008801]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; sugar-phosphatase activity [GO:0050308] GO:0000287; GO:0008801; GO:0016791; GO:0050308 +P43531 YNFM_ECOLI Inner membrane transport protein YnfM ynfM yzyC b1596 JW1588 yzyC ynfM 45,258 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P64519 YODD_ECOLI Uncharacterized protein YodD yodD b1953 JW5317 yodD 8,579 cellular response to acidic pH [GO:0071468]; cellular response to hydrogen peroxide [GO:0070301]; single-species biofilm formation on inanimate substrate [GO:0044011] cellular response to acidic pH [GO:0071468]; cellular response to hydrogen peroxide [GO:0070301]; single-species biofilm formation on inanimate substrate [GO:0044011] GO:0044011; GO:0070301; GO:0071468 +P76169 YNFA_ECOLI UPF0060 membrane protein YnfA ynfA b1582 JW1574 ynfA 11,920 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] GO:0005886; GO:0005887 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00010, ECO:0000269|PubMed:11867724, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00010, ECO:0000269|PubMed:11867724, ECO:0000269|PubMed:15919996}. +P0DPO9 YNFR_ECOLI Protein YnfR ynfR b4749 ynfR 2,308 +P42616 YQJC_ECOLI Protein YqjC yqjC b3097 JW5516 yqjC 13,906 +P39453 TORS_ECOLI Sensor protein TorS (EC 2.7.13.3) torS yccI b0993 JW5135 yccI torS 101,024 anaerobic respiration [GO:0009061]; cellular response to organic substance [GO:0071310]; phosphorelay signal transduction system [GO:0000160]; protein autophosphorylation [GO:0046777]; protein dephosphorylation [GO:0006470] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155]; anaerobic respiration [GO:0009061]; cellular response to organic substance [GO:0071310]; phosphorelay signal transduction system [GO:0000160]; protein autophosphorylation [GO:0046777]; protein dephosphorylation [GO:0006470] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155] GO:0000155; GO:0000160; GO:0004721; GO:0005524; GO:0005886; GO:0006470; GO:0009061; GO:0016021; GO:0042802; GO:0046777; GO:0071310 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0AGI8 TRKA_ECOLI Trk system potassium uptake protein TrkA (K(+)-uptake protein TrkA) trkA b3290 JW3251 trkA 50,368 potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813] cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234] cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; NAD binding [GO:0051287]; potassium ion transmembrane transporter activity [GO:0015079]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813] NAD binding [GO:0051287]; potassium ion transmembrane transporter activity [GO:0015079] GO:0005829; GO:0006813; GO:0015079; GO:0031234; GO:0051287; GO:0071805 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:2674131}; Peripheral membrane protein {ECO:0000269|PubMed:2674131}; Cytoplasmic side {ECO:0000269|PubMed:2674131}. Note=Peripherally bound to the inner side of the inner membrane via the TrkG and TrkH proteins. +P0AAT4 YBDG_ECOLI Miniconductance mechanosensitive channel YbdG ybdG mscM b0577 JW0566 mscM ybdG 46,603 cellular response to osmotic stress [GO:0071470]; response to osmotic stress [GO:0006970] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; mechanosensitive ion channel activity [GO:0008381]; cellular response to osmotic stress [GO:0071470]; response to osmotic stress [GO:0006970] identical protein binding [GO:0042802]; mechanosensitive ion channel activity [GO:0008381] GO:0005886; GO:0006970; GO:0008381; GO:0016021; GO:0042802; GO:0071470 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:20616037}; Multi-pass membrane protein {ECO:0000269|PubMed:20616037}. +Q47268 YLCH_ECOLI Uncharacterized protein YlcH ylcH b4588 b0546.1 ylcH 3,644 +P76576 YFGM_ECOLI Ancillary SecYEG translocon subunit (Periplasmic chaperone YfgM) yfgM b2513 JW2497 yfgM 22,176 integral component of external side of plasma membrane [GO:0071575]; protein-containing complex [GO:0032991] integral component of external side of plasma membrane [GO:0071575]; protein-containing complex [GO:0032991]; protein-containing complex binding [GO:0044877] protein-containing complex binding [GO:0044877] GO:0032991; GO:0044877; GO:0071575 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:21210718}; Single-pass type II membrane protein {ECO:0000269|PubMed:21210718}; Periplasmic side {ECO:0000269|PubMed:21210718}. +P43667 YGAH_ECOLI Uncharacterized protein YgaH ygaH b2683 JW2658 ygaH 12,024 L-valine transmembrane transport [GO:1903785] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; L-valine transmembrane transport [GO:1903785] GO:0005887; GO:1903785 +P0AB61 YCIN_ECOLI Protein YciN yciN b1273 JW1265 yciN 9,386 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P77402 YDIP_ECOLI Uncharacterized HTH-type transcriptional regulator YdiP ydiP b1696 JW1686 ydiP 34,894 DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0043565 +P0AAA5 YMCE_ECOLI Uncharacterized protein YmcE ymcE sfa b0991 JW0975 sfa ymcE 8,727 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +Q46786 YGEF_ECOLI Putative uncharacterized protein YgeF ygeF b2850 JW2818 ygeF 16,878 +P0AD49 YFIA_ECOLI Ribosome-associated inhibitor A (Protein Y) (pY) (Ribosome associated factor Y) (Spot Y) raiA yfiA b2597 JW2578 yfiA raiA 12,785 negative regulation of translational elongation [GO:0045900]; negative regulation of translational initiation [GO:0045947]; primary metabolic process [GO:0044238]; response to cold [GO:0009409] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843]; negative regulation of translational elongation [GO:0045900]; negative regulation of translational initiation [GO:0045947]; primary metabolic process [GO:0044238]; response to cold [GO:0009409] ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843] GO:0005829; GO:0009409; GO:0019843; GO:0022627; GO:0043022; GO:0043024; GO:0044238; GO:0045900; GO:0045947 +Q46791 YGEK_ECOLI Uncharacterized response regulatory protein YgeK ygeK ygeL b2856 JW5458/JW2824 b2855 ygeL ygeK 16,577 phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677] GO:0000160; GO:0003677; GO:0006355 +P33029 YEIQ_ECOLI Uncharacterized oxidoreductase YeiQ (EC 1.-.-.-) yeiQ b2172 JW2160 yeiQ 54,032 mannitol metabolic process [GO:0019594] oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; mannitol metabolic process [GO:0019594] oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] GO:0016616; GO:0019594 +P0DSH3 YIBX_ECOLI Protein YibX yibX b4795 yibX 8,757 +P0A8D6 YMDB_ECOLI O-acetyl-ADP-ribose deacetylase (EC 3.1.1.106) (Regulator of RNase III activity) ymdB b1045 JW1032 ymdB 18,880 negative regulation of endoribonuclease activity [GO:0060702]; purine nucleoside metabolic process [GO:0042278]; regulation of single-species biofilm formation on inanimate substrate [GO:1900231]; response to antibiotic [GO:0046677] deacetylase activity [GO:0019213]; endoribonuclease inhibitor activity [GO:0060698]; enzyme binding [GO:0019899]; O-acetyl-ADP-ribose deacetylase activity [GO:0061463]; purine nucleoside binding [GO:0001883]; negative regulation of endoribonuclease activity [GO:0060702]; purine nucleoside metabolic process [GO:0042278]; regulation of single-species biofilm formation on inanimate substrate [GO:1900231]; response to antibiotic [GO:0046677] deacetylase activity [GO:0019213]; endoribonuclease inhibitor activity [GO:0060698]; enzyme binding [GO:0019899]; O-acetyl-ADP-ribose deacetylase activity [GO:0061463]; purine nucleoside binding [GO:0001883] GO:0001883; GO:0019213; GO:0019899; GO:0042278; GO:0046677; GO:0060698; GO:0060702; GO:0061463; GO:1900231 +P32139 YIHR_ECOLI Uncharacterized protein YihR yihR b3879 JW3850 yihR 34,010 6-sulfoquinovose(1-) catabolic process [GO:1902777]; galactose catabolic process via UDP-galactose [GO:0033499]; glucose metabolic process [GO:0006006] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; aldose 1-epimerase activity [GO:0004034]; carbohydrate binding [GO:0030246]; 6-sulfoquinovose(1-) catabolic process [GO:1902777]; galactose catabolic process via UDP-galactose [GO:0033499]; glucose metabolic process [GO:0006006] aldose 1-epimerase activity [GO:0004034]; carbohydrate binding [GO:0030246] GO:0004034; GO:0005737; GO:0006006; GO:0030246; GO:0033499; GO:1902777 +P39349 YJGX_ECOLI Putative phosphoethanolamine transferase YjgX (EC 2.7.-.-) yjgX b4575 b4275/b4276/b4560 yjgX 13,956 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transferase activity [GO:0016740] transferase activity [GO:0016740] GO:0005886; GO:0016021; GO:0016740 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P77180 YKGH_ECOLI Uncharacterized protein YkgH ykgH b0310 JW0302 ykgH 25,589 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0DPP3 YECU_ECOLI Protein YecU yecU b4752 yecU 6,767 +P32685 YJBD_ECOLI Uncharacterized protein YjbD yjbD b4023 JW3983 yjbD 10,532 +P64631 YHFU_ECOLI Uncharacterized protein YhfU yhfU b3378 JW5697 yhfU 12,479 +P64503 YEBV_ECOLI Uncharacterized protein YebV yebV b1836 JW5302 yebV 8,753 +P37615 YHHM_ECOLI Uncharacterized protein YhhM yhhM b3467 JW3432 yhhM 13,496 +P0DPP4 YQFH_ECOLI Protein YqfH yqfH b4753 yqfH 2,617 +P45468 YRAQ_ECOLI UPF0718 protein YraQ yraQ b3151 JW3120 yraQ 37,257 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +A8DYQ1 YTHA_ECOLI Uncharacterized protein YthA ythA b4655 JW5769.1 ythA 4,779 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P0AD47 YPHA_ECOLI Inner membrane protein YphA yphA b2543 JW2527 yphA 15,211 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0DSI0 YTHB_ECOLI Protein YthB ythB b4802 ythB 3,574 +P69506 YTFE_ECOLI Iron-sulfur cluster repair protein YtfE (Regulator of cell morphogenesis and NO signaling) (RCMNS) ytfE b4209 JW4167 ytfE 24,883 iron incorporation into metallo-sulfur cluster [GO:0018283]; protein repair [GO:0030091]; response to nitrosative stress [GO:0051409]; response to oxidative stress [GO:0006979] cytosol [GO:0005829] cytosol [GO:0005829]; iron ion binding [GO:0005506]; iron incorporation into metallo-sulfur cluster [GO:0018283]; protein repair [GO:0030091]; response to nitrosative stress [GO:0051409]; response to oxidative stress [GO:0006979] iron ion binding [GO:0005506] GO:0005506; GO:0005829; GO:0006979; GO:0018283; GO:0030091; GO:0051409 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P76257 YOAA_ECOLI Probable ATP-dependent DNA helicase YoaA (EC 3.6.4.12) yoaA b1808 JW1797 yoaA 70,378 postreplication repair [GO:0006301] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; helicase activity [GO:0004386]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; postreplication repair [GO:0006301] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; helicase activity [GO:0004386]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872] GO:0003677; GO:0003678; GO:0004386; GO:0005524; GO:0006301; GO:0046872; GO:0051536 +P64496 YOAG_ECOLI Protein YoaG yoaG b1796 JW1785 yoaG 6,608 +P0AEB7 YOAB_ECOLI RutC family protein YoaB yoaB b1809 JW5295 yoaB 12,493 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P0AA57 YOBA_ECOLI Protein YobA yobA b1841 JW1830 yobA 13,410 copper ion transport [GO:0006825]; response to copper ion [GO:0046688] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; copper ion binding [GO:0005507]; copper ion transport [GO:0006825]; response to copper ion [GO:0046688] copper ion binding [GO:0005507] GO:0005507; GO:0006825; GO:0030288; GO:0046688 SUBCELLULAR LOCATION: Periplasm {ECO:0000250}. +V9HVX0 YPAA_ECOLI Uncharacterized protein YpaA ypaA b4543 ypaA 6,881 DNA recombination [GO:0006310] double-stranded DNA endodeoxyribonuclease activity [GO:1990238]; DNA recombination [GO:0006310] double-stranded DNA endodeoxyribonuclease activity [GO:1990238] GO:0006310; GO:1990238 +Q46809 YQEC_ECOLI Uncharacterized protein YqeC yqeC b2876 JW5464 yqeC 28,103 biosynthetic process [GO:0009058] ATP binding [GO:0005524]; biosynthetic process [GO:0009058] ATP binding [GO:0005524] GO:0005524; GO:0009058 +Q2EES0 YNFO_ECOLI Uncharacterized protein YnfO (Uncharacterized protein YnfO from Qin prophage) ynfO b4533 JW5251 ynfO 9,023 +P0ADU7 YQIB_ECOLI Uncharacterized protein YqiB yqiB yzzH b3033 JW3001 yzzH yqiB 16,548 +P07813 SYL_ECOLI Leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) leuS b0642 JW0637 leuS 97,234 leucyl-tRNA aminoacylation [GO:0006429] cytosol [GO:0005829] cytosol [GO:0005829]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; leucine-tRNA ligase activity [GO:0004823]; leucyl-tRNA aminoacylation [GO:0006429] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; leucine-tRNA ligase activity [GO:0004823] GO:0002161; GO:0004823; GO:0005524; GO:0005829; GO:0006429 SUBCELLULAR LOCATION: Cytoplasm. +P0AGJ9 SYY_ECOLI Tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) tyrS b1637 JW1629 tyrS 47,527 tRNA aminoacylation [GO:0043039]; tyrosyl-tRNA aminoacylation [GO:0006437] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; RNA binding [GO:0003723]; tyrosine-tRNA ligase activity [GO:0004831]; tRNA aminoacylation [GO:0043039]; tyrosyl-tRNA aminoacylation [GO:0006437] ATP binding [GO:0005524]; RNA binding [GO:0003723]; tyrosine-tRNA ligase activity [GO:0004831] GO:0003723; GO:0004831; GO:0005524; GO:0005829; GO:0006437; GO:0016020; GO:0043039 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02006, ECO:0000305}. +P30140 THIH_ECOLI 2-iminoacetate synthase (EC 4.1.99.19) (Dehydroglycine synthase) (Tyrosine lyase) thiH b3990 JW3953 thiH 43,320 cellular response to DNA damage stimulus [GO:0006974]; thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] 2-iminoacetate synthase activity [GO:0036355]; 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; cellular response to DNA damage stimulus [GO:0006974]; thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] 2-iminoacetate synthase activity [GO:0036355]; 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506] GO:0005506; GO:0006974; GO:0009228; GO:0009229; GO:0036355; GO:0051539 +P0AA25 THIO_ECOLI Thioredoxin 1 (Trx-1) trxA fipA tsnC b3781 JW5856 fipA tsnC trxA 11,807 cell redox homeostasis [GO:0045454]; glycerol ether metabolic process [GO:0006662]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; viral process [GO:0016032] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA polymerase processivity factor activity [GO:0030337]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein disulfide oxidoreductase activity [GO:0015035]; protein-disulfide reductase activity [GO:0047134]; cell redox homeostasis [GO:0045454]; glycerol ether metabolic process [GO:0006662]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; viral process [GO:0016032] DNA polymerase processivity factor activity [GO:0030337]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein disulfide oxidoreductase activity [GO:0015035]; protein-disulfide reductase activity [GO:0047134] GO:0005737; GO:0005829; GO:0006662; GO:0015035; GO:0016032; GO:0016671; GO:0030337; GO:0045454; GO:0047134; GO:1900264 +P0AGM7 URAA_ECOLI Uracil permease (Uracil transporter) uraA b2497 JW2482 uraA 45,060 uracil import across plasma membrane [GO:0098721]; uracil transport [GO:0015857] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; uracil transmembrane transporter activity [GO:0015210]; uracil:cation symporter activity [GO:0015505]; uracil import across plasma membrane [GO:0098721]; uracil transport [GO:0015857] uracil:cation symporter activity [GO:0015505]; uracil transmembrane transporter activity [GO:0015210] GO:0005886; GO:0005887; GO:0015210; GO:0015505; GO:0015857; GO:0016020; GO:0016021; GO:0098721 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P42597 UTPP_ECOLI UTP pyrophosphatase (EC 3.6.1.-) ygjP upp b3085 JW5514 upp ygjP 19,483 nucleotide metabolic process [GO:0009117] nucleotide binding [GO:0000166]; UTP diphosphatase activity [GO:0036221]; nucleotide metabolic process [GO:0009117] nucleotide binding [GO:0000166]; UTP diphosphatase activity [GO:0036221] GO:0000166; GO:0009117; GO:0036221 +P77657 YAGK_ECOLI Uncharacterized protein YagK yagK b0277 JW0271 yagK 24,471 +P39221 YABQ_ECOLI Protein YabQ yabQ b0057 b4659 JW0056 yabQ 5,737 +P0AAR5 YBAN_ECOLI Inner membrane protein YbaN ybaN b0468 JW0457 ybaN 14,770 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AAS3 YBBJ_ECOLI Inner membrane protein YbbJ ybbJ b0488 JW5065 ybbJ 16,939 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P37056 YAEF_ECOLI Probable lipoprotein peptidase YaeF (EC 3.4.-.-) (Uncharacterized lipoprotein YaeF) yaeF yaeK b0193 JW5016 yaeK yaeF 29,912 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; cysteine-type peptidase activity [GO:0008234] cysteine-type peptidase activity [GO:0008234] GO:0005886; GO:0008234 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P76137 YDET_ECOLI Fimbrial usher domain-containing protein YdeT ydeT b1505 JW1499 ydeT 41,616 pilus assembly [GO:0009297] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; fimbrial usher porin activity [GO:0015473]; pilus assembly [GO:0009297] fimbrial usher porin activity [GO:0015473] GO:0009279; GO:0009297; GO:0015473 +P76507 YFDI_ECOLI Uncharacterized protein YfdI yfdI b2352 JW5382 yfdI 51,484 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P76575 YFGJ_ECOLI Uncharacterized protein YfgJ yfgJ b2510 JW5402 yfgJ 7,994 bacterial-type flagellum-dependent swarming motility [GO:0071978] bacterial-type flagellum-dependent swarming motility [GO:0071978] GO:0071978 +P76549 YFFR_ECOLI Uncharacterized protein YffR yffR b2449 yffR 14,554 +P52139 YFJX_ECOLI Uncharacterized protein YfjX yfjX b2643 JW2624 yfjX 17,303 +A5A605 YKFM_ECOLI Uncharacterized protein YkfM ykfM b4586 ykfM 18,118 cellular response to DNA damage stimulus [GO:0006974]; response to antibiotic [GO:0046677] integral component of membrane [GO:0016021] integral component of membrane [GO:0016021]; cellular response to DNA damage stimulus [GO:0006974]; response to antibiotic [GO:0046677] GO:0006974; GO:0016021; GO:0046677 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0ADJ8 YIAA_ECOLI Inner membrane protein YiaA yiaA b3562 JW3534 yiaA 16,123 cellular response to DNA damage stimulus [GO:0006974] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cellular response to DNA damage stimulus [GO:0006974] GO:0005886; GO:0005887; GO:0006974 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0DPN6 YLIM_ECOLI Protein YliM yliM b4736 yliM 2,716 +P77162 YKFB_ECOLI Uncharacterized protein YkfB ykfB b0250 JW0239 ykfB 17,026 +P32106 YIBG_ECOLI Uncharacterized protein YibG (ORF-A3) yibG b3596 JW3570 yibG 18,079 +P32128 YIHF_ECOLI Uncharacterized protein YihF yihF b3861 JW5574 yihF 52,637 +P76362 YEES_ECOLI UPF0758 protein YeeS yeeS b2002 JW1984 yeeS 16,557 metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] GO:0008237; GO:0046872 +P46125 YEDI_ECOLI Inner membrane protein YedI yedI b1958 JW1941 yedI 32,191 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P39393 YJIV_ECOLI Putative uncharacterized protein YjiV yjiV mcrD b4486 mcrD yjiV 103,403 +Q2EES6 YOHO_ECOLI UPF0387 membrane protein YohO yohO b4542 JW5354 yohO 3,643 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01362}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01362}. +P77509 YPHE_ECOLI Uncharacterized ABC transporter ATP-binding protein YphE yphE b2547 JW2531 yphE 55,016 ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0042626 +P76228 YNJI_ECOLI Inner membrane protein YnjI ynjI b1762 JW5288 ynjI 40,346 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AA93 YPDA_ECOLI Sensor histidine kinase YpdA (EC 2.7.13.3) ypdA b2380 JW5388 ypdA 62,657 cellular response to nutrient [GO:0031670]; cell wall organization [GO:0071555]; signal transduction [GO:0007165] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673]; cell wall organization [GO:0071555]; cellular response to nutrient [GO:0031670]; signal transduction [GO:0007165] ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673] GO:0000155; GO:0004673; GO:0005524; GO:0005886; GO:0007165; GO:0016021; GO:0031670; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P77783 YNFF_ECOLI Probable dimethyl sulfoxide reductase chain YnfF (DMSO reductase) (EC 1.8.99.-) ynfF b1588 JW5260 ynfF 89,987 anaerobic respiration [GO:0009061] outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; 4 iron, 4 sulfur cluster binding [GO:0051539]; dimethyl sulfoxide reductase activity [GO:0009389]; electron transfer activity [GO:0009055]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; selenate reductase activity [GO:0033797]; anaerobic respiration [GO:0009061] 4 iron, 4 sulfur cluster binding [GO:0051539]; dimethyl sulfoxide reductase activity [GO:0009389]; electron transfer activity [GO:0009055]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; selenate reductase activity [GO:0033797] GO:0005886; GO:0009055; GO:0009061; GO:0009389; GO:0030151; GO:0030288; GO:0033797; GO:0043546; GO:0051539 SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. +P0DSH7 YSGD_ECOLI Protein YsgD ysgD b4799 ysgD 2,140 +P78067 YNJE_ECOLI Thiosulfate sulfurtransferase YnjE (EC 2.8.1.1) ynjE b1757 JW5287 ynjE 48,229 transsulfuration [GO:0019346] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; sulfurtransferase activity [GO:0016783]; thiosulfate sulfurtransferase activity [GO:0004792]; transsulfuration [GO:0019346] sulfurtransferase activity [GO:0016783]; thiosulfate sulfurtransferase activity [GO:0004792] GO:0004792; GO:0016783; GO:0019346; GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P0AFH2 OPPB_ECOLI Oligopeptide transport system permease protein OppB oppB b1244 JW1236 oppB 33,443 protein transport [GO:0015031]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein transport [GO:0015031]; transmembrane transport [GO:0055085] GO:0005886; GO:0015031; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AFH0 OGT_ECOLI Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase) ogt b1335 JW1329 ogt 19,179 DNA dealkylation involved in DNA repair [GO:0006307]; methylation [GO:0032259] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; methylated-DNA-[protein]-cysteine S-methyltransferase activity [GO:0003908]; DNA dealkylation involved in DNA repair [GO:0006307]; methylation [GO:0032259] methylated-DNA-[protein]-cysteine S-methyltransferase activity [GO:0003908] GO:0003908; GO:0005737; GO:0006307; GO:0032259 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00772}. +P0A9N0 PTSO_ECOLI Phosphocarrier protein NPr (Nitrogen-related HPr) ptsO npr rpoR yhbK b3206 JW3173 npr rpoR yhbK ptsO 9,810 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; protein phosphorylation [GO:0006468]; response to organonitrogen compound [GO:0010243] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; transferase activity, transferring phosphorus-containing groups [GO:0016772]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; protein phosphorylation [GO:0006468]; response to organonitrogen compound [GO:0010243] transferase activity, transferring phosphorus-containing groups [GO:0016772] GO:0005737; GO:0006468; GO:0009401; GO:0010243; GO:0016772 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P24241 PTIBC_ECOLI PTS system arbutin-, cellobiose-, and salicin-specific EIIBC component (EIIBC-Asc) (EII-Asc) [Includes: Arbutin-, cellobiose-, and salicin-specific phosphotransferase enzyme IIB component (EC 2.7.1.-) (PTS system arbutin-, cellobiose-, and salicin-specific EIIB component); Arbutin, cellobiose, and salicin permease IIC component (PTS system arbutin-, cellobiose-, and salicin-specific EIIC component)] ascF b2715 JW5435 ascF 51,026 carbohydrate transmembrane transport [GO:0034219]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; trehalose transport [GO:0015771] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; protein-phosphocysteine-trehalose phosphotransferase system transporter activity [GO:0090589]; carbohydrate transmembrane transport [GO:0034219]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; trehalose transport [GO:0015771] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; protein-phosphocysteine-trehalose phosphotransferase system transporter activity [GO:0090589] GO:0005886; GO:0008982; GO:0009401; GO:0015771; GO:0016021; GO:0016301; GO:0034219; GO:0090563; GO:0090589 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00426, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00426, ECO:0000269|PubMed:15919996}. +P0AFM9 PSPB_ECOLI Phage shock protein B pspB b1305 JW1298 pspB 8,763 phage shock [GO:0009271]; regulation of transcription, DNA-templated [GO:0006355] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; phage shock [GO:0009271]; regulation of transcription, DNA-templated [GO:0006355] GO:0005886; GO:0006355; GO:0009271; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein. +P0C018 RL18_ECOLI 50S ribosomal protein L18 (Large ribosomal subunit protein uL18) rplR b3304 JW3266 rplR 12,770 translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; 5S rRNA binding [GO:0008097]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412] 5S rRNA binding [GO:0008097]; structural constituent of ribosome [GO:0003735] GO:0003735; GO:0005829; GO:0006412; GO:0008097; GO:0022625 +P27830 RMLB2_ECOLI dTDP-glucose 4,6-dehydratase 2 (EC 4.2.1.46) rffG b3788 JW5598 rffG 39,754 enterobacterial common antigen biosynthetic process [GO:0009246]; extracellular polysaccharide biosynthetic process [GO:0045226]; lipopolysaccharide biosynthetic process [GO:0009103]; nucleotide-sugar metabolic process [GO:0009225] dTDP-glucose 4,6-dehydratase activity [GO:0008460]; enterobacterial common antigen biosynthetic process [GO:0009246]; extracellular polysaccharide biosynthetic process [GO:0045226]; lipopolysaccharide biosynthetic process [GO:0009103]; nucleotide-sugar metabolic process [GO:0009225] dTDP-glucose 4,6-dehydratase activity [GO:0008460] GO:0008460; GO:0009103; GO:0009225; GO:0009246; GO:0045226 +P75851 SSUC_ECOLI Putative aliphatic sulfonates transport permease protein SsuC ssuC ycbM b0934 JW5121 ycbM ssuC 28,925 alkanesulfonate transport [GO:0042918]; sulfur compound metabolic process [GO:0006790] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; alkanesulfonate transmembrane transporter activity [GO:0042959]; transmembrane transporter activity [GO:0022857]; alkanesulfonate transport [GO:0042918]; sulfur compound metabolic process [GO:0006790] alkanesulfonate transmembrane transporter activity [GO:0042959]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0006790; GO:0022857; GO:0042918; GO:0042959 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +Q46812 SSNA_ECOLI Putative aminohydrolase SsnA (EC 3.-.-.-) ssnA ygfL b2879 JW2847 ygfL ssnA 48,842 negative regulation of cell growth [GO:0030308] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]; metal ion binding [GO:0046872]; negative regulation of cell growth [GO:0030308] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]; metal ion binding [GO:0046872] GO:0016810; GO:0030308; GO:0046872 +P77243 PRPD_ECOLI 2-methylcitrate dehydratase (2-MC dehydratase) (EC 4.2.1.79) ((2S,3S)-2-methylcitrate dehydratase) (Aconitate hydratase) (ACN) (Aconitase) (EC 4.2.1.3) prpD yahT b0334 JW0325 yahT prpD 53,952 propionate metabolic process, methylcitrate cycle [GO:0019679]; tricarboxylic acid cycle [GO:0006099] 2 iron, 2 sulfur cluster binding [GO:0051537]; 2-methylcitrate dehydratase activity [GO:0047547]; aconitate hydratase activity [GO:0003994]; citrate dehydratase activity [GO:0047780]; propionate metabolic process, methylcitrate cycle [GO:0019679]; tricarboxylic acid cycle [GO:0006099] 2 iron, 2 sulfur cluster binding [GO:0051537]; 2-methylcitrate dehydratase activity [GO:0047547]; aconitate hydratase activity [GO:0003994]; citrate dehydratase activity [GO:0047780] GO:0003994; GO:0006099; GO:0019679; GO:0047547; GO:0047780; GO:0051537 +P23869 PPIB_ECOLI Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Rotamase B) ppiB b0525 JW0514 ppiB 18,153 protein folding [GO:0006457] cytosol [GO:0005829] cytosol [GO:0005829]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding [GO:0006457] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] GO:0003755; GO:0005829; GO:0006457 SUBCELLULAR LOCATION: Cytoplasm. +P05458 PTRA_ECOLI Protease 3 (EC 3.4.24.55) (Pitrilysin) (Protease III) (Protease pi) ptrA ptr b2821 JW2789 ptr ptrA 107,708 proteolysis [GO:0006508] cytoplasm [GO:0005737]; outer membrane-bounded periplasmic space [GO:0030288] cytoplasm [GO:0005737]; outer membrane-bounded periplasmic space [GO:0030288]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; proteolysis [GO:0006508] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] GO:0004222; GO:0005737; GO:0006508; GO:0008270; GO:0030288 SUBCELLULAR LOCATION: Periplasm. +P77495 PRPE_ECOLI Propionate--CoA ligase (EC 6.2.1.17) (Propionyl-CoA synthetase) prpE yahU b0335 JW0326 yahU prpE 69,351 propionate catabolic process, 2-methylcitrate cycle [GO:0019629] ATP binding [GO:0005524]; propionate-CoA ligase activity [GO:0050218]; propionate catabolic process, 2-methylcitrate cycle [GO:0019629] ATP binding [GO:0005524]; propionate-CoA ligase activity [GO:0050218] GO:0005524; GO:0019629; GO:0050218 +P0AFN2 PSPC_ECOLI Phage shock protein C pspC b1306 JW1299 pspC 13,517 positive regulation of macromolecule biosynthetic process [GO:0010557] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; positive regulation of macromolecule biosynthetic process [GO:0010557] GO:0005886; GO:0010557; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P0AFM6 PSPA_ECOLI Phage shock protein A pspA b1304 JW1297 pspA 25,493 negative regulation of DNA-binding transcription factor activity [GO:0043433]; phage shock [GO:0009271]; response to heat [GO:0009408] cell pole [GO:0060187]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234] cell pole [GO:0060187]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; identical protein binding [GO:0042802]; phospholipid binding [GO:0005543]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; phage shock [GO:0009271]; response to heat [GO:0009408] identical protein binding [GO:0042802]; phospholipid binding [GO:0005543] GO:0005543; GO:0005829; GO:0009271; GO:0009408; GO:0031234; GO:0042802; GO:0043433; GO:0060187 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19555453}. Cell inner membrane {ECO:0000269|PubMed:19555453}; Peripheral membrane protein {ECO:0000269|PubMed:19555453}; Cytoplasmic side {ECO:0000269|PubMed:19555453}. Note=Localizes at both cell poles and along the length of the cell. +P0A8V0 RBN_ECOLI Ribonuclease BN (RNase BN) (EC 3.1.-.-) (Ribonuclease Z homolog) (RNase Z homolog) rbn elaC rnz b2268 JW2263 elaC rnz rbn 32,930 tRNA processing [GO:0008033] 3'-tRNA processing endoribonuclease activity [GO:0042781]; endoribonuclease activity, producing 5'-phosphomonoesters [GO:0016891]; exoribonuclease activity [GO:0004532]; exoribonuclease activity, producing 5'-phosphomonoesters [GO:0016896]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518]; zinc ion binding [GO:0008270]; tRNA processing [GO:0008033] 3'-tRNA processing endoribonuclease activity [GO:0042781]; endoribonuclease activity, producing 5'-phosphomonoesters [GO:0016891]; exoribonuclease activity [GO:0004532]; exoribonuclease activity, producing 5'-phosphomonoesters [GO:0016896]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518]; zinc ion binding [GO:0008270] GO:0004518; GO:0004532; GO:0008033; GO:0008270; GO:0016891; GO:0016896; GO:0042781; GO:0046872 +P08394 RECB_ECOLI RecBCD enzyme subunit RecB (EC 3.1.11.5) (Exodeoxyribonuclease V 135 kDa polypeptide) (Exodeoxyribonuclease V beta chain) (Exonuclease V subunit RecB) (ExoV subunit RecB) (Helicase/nuclease RecBCD subunit RecB) recB ior rorA b2820 JW2788 ior rorA recB 133,959 clearance of foreign intracellular DNA [GO:0044355]; DNA recombination [GO:0006310]; double-strand break repair via homologous recombination [GO:0000724]; recombinational repair [GO:0000725]; response to radiation [GO:0009314] cytosol [GO:0005829]; exodeoxyribonuclease V complex [GO:0009338] cytosol [GO:0005829]; exodeoxyribonuclease V complex [GO:0009338]; 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATPase activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]; endodeoxyribonuclease activity [GO:0004520]; exodeoxyribonuclease V activity [GO:0008854]; magnesium ion binding [GO:0000287]; clearance of foreign intracellular DNA [GO:0044355]; DNA recombination [GO:0006310]; double-strand break repair via homologous recombination [GO:0000724]; recombinational repair [GO:0000725]; response to radiation [GO:0009314] 3'-5' DNA helicase activity [GO:0043138]; ATPase activity, acting on DNA [GO:0008094]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]; endodeoxyribonuclease activity [GO:0004520]; exodeoxyribonuclease V activity [GO:0008854]; magnesium ion binding [GO:0000287] GO:0000287; GO:0000724; GO:0000725; GO:0003677; GO:0003678; GO:0004520; GO:0005524; GO:0005829; GO:0006310; GO:0008094; GO:0008854; GO:0009314; GO:0009338; GO:0015616; GO:0043138; GO:0044355 +P28369 RFH_ECOLI Putative peptide chain release factor homolog (RF-H) prfH b0236 JW0226 prfH 18,834 translation release factor activity [GO:0003747] translation release factor activity [GO:0003747] GO:0003747 +P0A7N1 RL31B_ECOLI 50S ribosomal protein L31 type B (Large ribosomal subunit protein bL31-B) ykgM rpmE2 b0296 JW5035 rpmE2 ykgM 9,920 cellular response to zinc ion starvation [GO:0034224]; translation [GO:0006412] ribosome [GO:0005840] ribosome [GO:0005840]; structural constituent of ribosome [GO:0003735]; cellular response to zinc ion starvation [GO:0034224]; translation [GO:0006412] structural constituent of ribosome [GO:0003735] GO:0003735; GO:0005840; GO:0006412; GO:0034224 +P10100 RLPA_ECOLI Endolytic peptidoglycan transglycosylase RlpA (EC 4.2.2.-) (Rare lipoprotein A) rlpA b0633 JW0628 rlpA 37,528 cell wall organization [GO:0071555]; peptidoglycan metabolic process [GO:0000270] cell outer membrane [GO:0009279]; plasma membrane [GO:0005886] cell outer membrane [GO:0009279]; plasma membrane [GO:0005886]; lyase activity [GO:0016829]; lytic endotransglycosylase activity [GO:0008932]; peptidoglycan binding [GO:0042834]; cell wall organization [GO:0071555]; peptidoglycan metabolic process [GO:0000270] lyase activity [GO:0016829]; lytic endotransglycosylase activity [GO:0008932]; peptidoglycan binding [GO:0042834] GO:0000270; GO:0005886; GO:0008932; GO:0009279; GO:0016829; GO:0042834; GO:0071555 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_02071}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_02071, ECO:0000305|PubMed:3316191}. Note=Localizes at the septal ring. Is also associated with some other structures/complexes along the cell cylinder. {ECO:0000269|PubMed:19684127, ECO:0000269|PubMed:19880599}. +P37744 RMLA1_ECOLI Glucose-1-phosphate thymidylyltransferase 1 (G1P-TT 1) (EC 2.7.7.24) (dTDP-glucose pyrophosphorylase 1) (dTDP-glucose synthase 1) rfbA rmlA rmlA1 b2039 JW2024 rmlA rmlA1 rfbA 32,694 dTDP-rhamnose biosynthetic process [GO:0019305]; extracellular polysaccharide biosynthetic process [GO:0045226]; O antigen biosynthetic process [GO:0009243] cytosol [GO:0005829] cytosol [GO:0005829]; glucose-1-phosphate thymidylyltransferase activity [GO:0008879]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; dTDP-rhamnose biosynthetic process [GO:0019305]; extracellular polysaccharide biosynthetic process [GO:0045226]; O antigen biosynthetic process [GO:0009243] glucose-1-phosphate thymidylyltransferase activity [GO:0008879]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] GO:0005829; GO:0008879; GO:0009243; GO:0019305; GO:0042802; GO:0045226; GO:0046872 +P0AFW8 ROF_ECOLI Protein rof rof yaeO b0189 JW0184 yaeO rof 9,480 regulation of DNA-templated transcription, termination [GO:0031554]; transcription antitermination [GO:0031564] regulation of DNA-templated transcription, termination [GO:0031554]; transcription antitermination [GO:0031564] GO:0031554; GO:0031564 +P0AG67 RS1_ECOLI 30S ribosomal protein S1 (Bacteriophage Q beta RNA-directed RNA polymerase subunit I) (Small ribosomal subunit protein bS1) rpsA ssyF b0911 JW0894 ssyF rpsA 61,158 negative regulation of cytoplasmic translation [GO:2000766]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytoplasm [GO:0005737]; cytosolic small ribosomal subunit [GO:0022627]; membrane [GO:0016020] cytoplasm [GO:0005737]; cytosolic small ribosomal subunit [GO:0022627]; membrane [GO:0016020]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; negative regulation of cytoplasmic translation [GO:2000766]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735] GO:0000028; GO:0003723; GO:0003729; GO:0003735; GO:0005737; GO:0006412; GO:0016020; GO:0022627; GO:2000766 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:342903}. +P0AG59 RS14_ECOLI 30S ribosomal protein S14 (Small ribosomal subunit protein uS14) rpsN b3307 JW3269 rpsN 11,580 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935] cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GO:0000028; GO:0003735; GO:0006412; GO:0015935; GO:0019843; GO:0022627 +P38035 RTCR_ECOLI Transcriptional regulatory protein RtcR rtcR yhgB b3422 JW3385 yhgB rtcR 60,299 phosphorelay signal transduction system [GO:0000160]; positive regulation of transcription, DNA-templated [GO:0045893] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription factor binding [GO:0008134]; phosphorelay signal transduction system [GO:0000160]; positive regulation of transcription, DNA-templated [GO:0045893] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription factor binding [GO:0008134] GO:0000160; GO:0003677; GO:0003700; GO:0005524; GO:0008134; GO:0045893 +P75897 RUTB_ECOLI Ureidoacrylate amidohydrolase RutB (EC 3.5.1.110) rutB ycdL b1011 JW5139 ycdL rutB 25,209 nitrogen utilization [GO:0019740]; pyrimidine nucleobase catabolic process [GO:0006208]; uracil catabolic process [GO:0006212] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; nitrogen utilization [GO:0019740]; pyrimidine nucleobase catabolic process [GO:0006208]; uracil catabolic process [GO:0006212] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811] GO:0006208; GO:0006212; GO:0016811; GO:0019740 +P0A814 RUVC_ECOLI Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4) (Holliday junction nuclease RuvC) (Holliday junction resolvase RuvC) ruvC b1863 JW1852 ruvC 18,747 recombinational repair [GO:0000725]; response to radiation [GO:0009314] cytoplasm [GO:0005737]; Holliday junction resolvase complex [GO:0048476] cytoplasm [GO:0005737]; Holliday junction resolvase complex [GO:0048476]; crossover junction endodeoxyribonuclease activity [GO:0008821]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]; recombinational repair [GO:0000725]; response to radiation [GO:0009314] crossover junction endodeoxyribonuclease activity [GO:0008821]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676] GO:0000287; GO:0000725; GO:0003676; GO:0005737; GO:0008821; GO:0009314; GO:0048476 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21219465}. Note=In 15% of cell localizes to discrete nucleoid foci (probable DNA damage sites) upon treatment with mitomycin C (MMC) for 2 hours. +P07026 SDIA_ECOLI Regulatory protein SdiA sdiA b1916 JW1901 sdiA 28,117 cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation of cytokinesis [GO:0032467]; positive regulation of DNA-templated transcription, initiation [GO:2000144] DNA binding [GO:0003677]; cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation of cytokinesis [GO:0032467]; positive regulation of DNA-templated transcription, initiation [GO:2000144] DNA binding [GO:0003677] GO:0003677; GO:0007049; GO:0032467; GO:0051301; GO:2000144 +P09158 SPEE_ECOLI Polyamine aminopropyltransferase (Cadaverine aminopropyltransferase) (EC 2.5.1.-) (Putrescine aminopropyltransferase) (PAPT) (Spermidine aminopropyltransferase) (EC 2.5.1.79) (Spermidine synthase) (SPDS) (SPDSY) (EC 2.5.1.16) (Spermine synthase) (EC 2.5.1.22) (Thermospermine synthase) speE b0121 JW0117 speE 32,321 spermidine biosynthetic process [GO:0008295] cytosol [GO:0005829] cytosol [GO:0005829]; cadaverine aminopropyltransferase activity [GO:0043918]; spermidine synthase activity [GO:0004766]; spermine synthase activity [GO:0016768]; thermospermine synthase activity [GO:0010487]; spermidine biosynthetic process [GO:0008295] cadaverine aminopropyltransferase activity [GO:0043918]; spermidine synthase activity [GO:0004766]; spermine synthase activity [GO:0016768]; thermospermine synthase activity [GO:0010487] GO:0004766; GO:0005829; GO:0008295; GO:0010487; GO:0016768; GO:0043918 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00198}. +P23862 PRIC_ECOLI Primosomal replication protein N'' priC b0467 JW0456 priC 20,375 DNA-dependent DNA replication [GO:0006261]; DNA replication, synthesis of RNA primer [GO:0006269]; DNA replication initiation [GO:0006270] primosome complex [GO:1990077] primosome complex [GO:1990077]; DNA binding [GO:0003677]; DNA replication initiation [GO:0006270]; DNA replication, synthesis of RNA primer [GO:0006269]; DNA-dependent DNA replication [GO:0006261] DNA binding [GO:0003677] GO:0003677; GO:0006261; GO:0006269; GO:0006270; GO:1990077 +P0A7B1 PPK1_ECOLI Polyphosphate kinase (EC 2.7.4.1) (ATP-polyphosphate phosphotransferase) (Polyphosphoric acid kinase) ppk b2501 JW2486 ppk 80,432 ATP generation from ADP [GO:0006757]; polyphosphate biosynthetic process [GO:0006799]; protein autophosphorylation [GO:0046777] cytosol [GO:0005829]; periplasmic side of cell outer membrane [GO:0031241]; plasma membrane [GO:0005886]; polyphosphate kinase complex [GO:0009358] cytosol [GO:0005829]; periplasmic side of cell outer membrane [GO:0031241]; plasma membrane [GO:0005886]; polyphosphate kinase complex [GO:0009358]; ATP binding [GO:0005524]; diphosphotransferase activity [GO:0016778]; metal ion binding [GO:0046872]; phosphotransferase activity, phosphate group as acceptor [GO:0016776]; polyphosphate kinase activity [GO:0008976]; polyphosphate:AMP phosphotransferase activity [GO:0043751]; ATP generation from ADP [GO:0006757]; polyphosphate biosynthetic process [GO:0006799]; protein autophosphorylation [GO:0046777] ATP binding [GO:0005524]; diphosphotransferase activity [GO:0016778]; metal ion binding [GO:0046872]; phosphotransferase activity, phosphate group as acceptor [GO:0016776]; polyphosphate:AMP phosphotransferase activity [GO:0043751]; polyphosphate kinase activity [GO:0008976] GO:0005524; GO:0005829; GO:0005886; GO:0006757; GO:0006799; GO:0008976; GO:0009358; GO:0016776; GO:0016778; GO:0031241; GO:0043751; GO:0046777; GO:0046872 SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1331061}; Peripheral membrane protein {ECO:0000269|PubMed:1331061}. Note=Associated with the outer membrane in overproducing cells. {ECO:0000269|PubMed:1331061}. +P23538 PPSA_ECOLI Phosphoenolpyruvate synthase (PEP synthase) (EC 2.7.9.2) (Pyruvate, water dikinase) ppsA pps b1702 JW1692 pps ppsA 87,435 gluconeogenesis [GO:0006094]; pyruvate metabolic process [GO:0006090] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; pyruvate, water dikinase activity [GO:0008986]; gluconeogenesis [GO:0006094]; pyruvate metabolic process [GO:0006090] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; pyruvate, water dikinase activity [GO:0008986] GO:0000287; GO:0005524; GO:0005829; GO:0006090; GO:0006094; GO:0008986 +P42905 PTPC2_ECOLI Putative N-acetylgalactosamine permease IIC component 2 (EIIC-Aga') (PTS system N-acetylgalactosamine-specific EIIC component 2) agaW b3134 agaW 13,721 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] GO:0005887; GO:0009401 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein. Note=When overexpressed using vectors that provide a promoter and ribosome binding site (PubMed:15919996). {ECO:0000269|PubMed:15919996}. +P0A9U6 PUUR_ECOLI HTH-type transcriptional regulator PuuR puuR ycjC b1299 JW1292 ycjC puuR 20,092 putrescine catabolic process [GO:0009447]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; putrescine catabolic process [GO:0009447]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006351; GO:0006355; GO:0009447 +P0AAV4 PXPB_ECOLI 5-oxoprolinase subunit B (5-OPase subunit B) (EC 3.5.2.9) (5-oxoprolinase (ATP-hydrolyzing) subunit B) pxpB ybgJ b0711 JW0701 ybgJ pxpB 23,947 5-oxoprolinase (ATP-hydrolyzing) activity [GO:0017168]; ATP binding [GO:0005524] 5-oxoprolinase (ATP-hydrolyzing) activity [GO:0017168]; ATP binding [GO:0005524] GO:0005524; GO:0017168 +P36999 RLMA_ECOLI 23S rRNA (guanine(745)-N(1))-methyltransferase (EC 2.1.1.187) (23S rRNA m1G745 methyltransferase) (Ribosomal RNA large subunit methyltransferase A) rlmA rrmA yebH b1822 JW1811 rrmA yebH rlmA 30,419 rRNA base methylation [GO:0070475] 23S rRNA (guanine(745)-N(1))-methyltransferase activity [GO:0052911]; methyltransferase activity [GO:0008168]; rRNA (guanine-N1-)-methyltransferase activity [GO:0008989]; zinc ion binding [GO:0008270]; rRNA base methylation [GO:0070475] 23S rRNA (guanine(745)-N(1))-methyltransferase activity [GO:0052911]; methyltransferase activity [GO:0008168]; rRNA (guanine-N1-)-methyltransferase activity [GO:0008989]; zinc ion binding [GO:0008270] GO:0008168; GO:0008270; GO:0008989; GO:0052911; GO:0070475 +P0A7Z0 RPIA_ECOLI Ribose-5-phosphate isomerase A (EC 5.3.1.6) (Phosphoriboisomerase A) (PRI) rpiA ygfC b2914 JW5475 ygfC rpiA 22,860 D-ribose metabolic process [GO:0006014]; pentose-phosphate shunt, non-oxidative branch [GO:0009052] cytosol [GO:0005829] cytosol [GO:0005829]; identical protein binding [GO:0042802]; ribose-5-phosphate isomerase activity [GO:0004751]; D-ribose metabolic process [GO:0006014]; pentose-phosphate shunt, non-oxidative branch [GO:0009052] identical protein binding [GO:0042802]; ribose-5-phosphate isomerase activity [GO:0004751] GO:0004751; GO:0005829; GO:0006014; GO:0009052; GO:0042802 +P0A7R9 RS11_ECOLI 30S ribosomal protein S11 (Small ribosomal subunit protein uS11) rpsK b3297 JW3259 rpsK 13,845 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; mRNA 5'-UTR binding [GO:0048027]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] mRNA 5'-UTR binding [GO:0048027]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735] GO:0000028; GO:0000462; GO:0003735; GO:0005829; GO:0006412; GO:0022627; GO:0048027; GO:0070181 +P0AGB3 RPOH_ECOLI RNA polymerase sigma factor RpoH (Heat shock regulatory protein F33.4) (RNA polymerase sigma-32 factor) rpoH fam hin htpR b3461 JW3426 fam hin htpR rpoH 32,469 bacterial transcription [GO:0001121]; DNA recombination [GO:0006310]; regulation of gene expression [GO:0010468]; regulation of transcription, DNA-templated [GO:0006355]; response to heat [GO:0009408]; transcription, DNA-templated [GO:0006351]; transcription initiation from bacterial-type RNA polymerase promoter [GO:0001123] cytosol [GO:0005829]; invertasome [GO:0031421]; plasma membrane [GO:0005886] cytosol [GO:0005829]; invertasome [GO:0031421]; plasma membrane [GO:0005886]; bacterial-type RNA polymerase core enzyme binding [GO:0001000]; bacterial-type RNA polymerase core promoter sequence-specific DNA binding [GO:0000985]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; sigma factor activity [GO:0016987]; site-specific recombinase activity [GO:0009009]; bacterial transcription [GO:0001121]; DNA recombination [GO:0006310]; regulation of gene expression [GO:0010468]; regulation of transcription, DNA-templated [GO:0006355]; response to heat [GO:0009408]; transcription initiation from bacterial-type RNA polymerase promoter [GO:0001123]; transcription, DNA-templated [GO:0006351] bacterial-type RNA polymerase core enzyme binding [GO:0001000]; bacterial-type RNA polymerase core promoter sequence-specific DNA binding [GO:0000985]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; sigma factor activity [GO:0016987]; site-specific recombinase activity [GO:0009009] GO:0000985; GO:0001000; GO:0001121; GO:0001123; GO:0001216; GO:0003677; GO:0005829; GO:0005886; GO:0006310; GO:0006351; GO:0006355; GO:0009009; GO:0009408; GO:0010468; GO:0016987; GO:0031421 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00961}. +P00926 SDHD_ECOLI D-serine dehydratase (EC 4.3.1.18) (D-serine deaminase) (DSD) dsdA b2366 JW2363 dsdA 47,901 cellular response to DNA damage stimulus [GO:0006974]; detoxification of nitrogen compound [GO:0051410]; D-serine catabolic process [GO:0036088]; D-serine metabolic process [GO:0070178]; L-serine catabolic process [GO:0006565]; threonine catabolic process [GO:0006567] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; D-serine ammonia-lyase activity [GO:0008721]; hydro-lyase activity [GO:0016836]; L-serine ammonia-lyase activity [GO:0003941]; L-threonine ammonia-lyase activity [GO:0004794]; pyridoxal phosphate binding [GO:0030170]; cellular response to DNA damage stimulus [GO:0006974]; D-serine catabolic process [GO:0036088]; D-serine metabolic process [GO:0070178]; detoxification of nitrogen compound [GO:0051410]; L-serine catabolic process [GO:0006565]; threonine catabolic process [GO:0006567] D-serine ammonia-lyase activity [GO:0008721]; hydro-lyase activity [GO:0016836]; L-serine ammonia-lyase activity [GO:0003941]; L-threonine ammonia-lyase activity [GO:0004794]; pyridoxal phosphate binding [GO:0030170] GO:0003941; GO:0004794; GO:0005737; GO:0005829; GO:0006565; GO:0006567; GO:0006974; GO:0008721; GO:0016836; GO:0030170; GO:0036088; GO:0051410; GO:0070178 +P0AG90 SECD_ECOLI Protein translocase subunit SecD (Sec translocon accessory complex subunit SecD) secD b0408 JW0398 secD 66,632 intracellular protein transmembrane transport [GO:0065002]; protein targeting [GO:0006605]; protein transport [GO:0015031]; protein transport by the Sec complex [GO:0043952] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; P-P-bond-hydrolysis-driven protein transmembrane transporter activity [GO:0015450]; intracellular protein transmembrane transport [GO:0065002]; protein targeting [GO:0006605]; protein transport [GO:0015031]; protein transport by the Sec complex [GO:0043952] P-P-bond-hydrolysis-driven protein transmembrane transporter activity [GO:0015450] GO:0005886; GO:0006605; GO:0015031; GO:0015450; GO:0016021; GO:0043952; GO:0065002 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:16079137}. +P33012 SBMC_ECOLI DNA gyrase inhibitor sbmC gyrI yeeB b2009 JW1991 gyrI yeeB sbmC 18,081 cellular response to DNA damage stimulus [GO:0006974]; negative regulation of DNA-dependent DNA replication [GO:2000104] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity [GO:0008657]; enzyme binding [GO:0019899]; cellular response to DNA damage stimulus [GO:0006974]; negative regulation of DNA-dependent DNA replication [GO:2000104] DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity [GO:0008657]; enzyme binding [GO:0019899] GO:0005737; GO:0006974; GO:0008657; GO:0019899; GO:2000104 SUBCELLULAR LOCATION: Cytoplasm. +P58035 SGCB_ECOLI Putative phosphotransferase enzyme IIB component SgcB (EC 2.7.1.-) (Putative PTS system EIIB component) sgcB b4565 JW5967 sgcB 9,803 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982] GO:0005737; GO:0008982; GO:0009401; GO:0016301 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P00956 SYI_ECOLI Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) ileS ilvS b0026 JW0024 ilvS ileS 104,297 isoleucyl-tRNA aminoacylation [GO:0006428]; response to antibiotic [GO:0046677] cytosol [GO:0005829] cytosol [GO:0005829]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; isoleucine-tRNA ligase activity [GO:0004822]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]; isoleucyl-tRNA aminoacylation [GO:0006428]; response to antibiotic [GO:0046677] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; isoleucine-tRNA ligase activity [GO:0004822]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] GO:0000049; GO:0002161; GO:0004822; GO:0005524; GO:0005829; GO:0006428; GO:0008270; GO:0046677 SUBCELLULAR LOCATION: Cytoplasm. +P16677 PHNC_ECOLI Phosphonates import ATP-binding protein PhnC (EC 7.3.2.2) phnC b4106 JW4067 phnC 29,431 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ABC-type phosphonate transporter activity [GO:0015416]; ATP binding [GO:0005524] ABC-type phosphonate transporter activity [GO:0015416]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0015416 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01713}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01713}. +P0A9K1 PHOH_ECOLI Protein PhoH (Phosphate starvation-inducible protein PsiH) phoH psiH b1020 JW1005 psiH phoH 39,265 cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524] ATP binding [GO:0005524] GO:0005524; GO:0005829 SUBCELLULAR LOCATION: Cytoplasm. +P0AFL1 POTI_ECOLI Putrescine transport system permease protein PotI potI b0857 JW0841 potI 30,541 putrescine transport [GO:0015847]; transmembrane transport [GO:0055085] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; putrescine transport [GO:0015847]; transmembrane transport [GO:0055085] GO:0005886; GO:0015847; GO:0043190; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P0AFL9 PQIA_ECOLI Intermembrane transport protein PqiA (Paraquat-inducible protein A) pqiA pqi5A b0950 JW0933 pqi5A pqiA 46,463 integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] GO:0005886; GO:0005887; GO:0016020 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:27795327}; Multi-pass membrane protein {ECO:0000269|PubMed:27795327}. +P08244 PYRF_ECOLI Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMP decarboxylase) (OMPDCase) (OMPdecase) pyrF b1281 JW1273 pyrF 26,350 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; nucleobase-containing small molecule interconversion [GO:0015949] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; carboxy-lyase activity [GO:0016831]; orotidine-5'-phosphate decarboxylase activity [GO:0004590]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; nucleobase-containing small molecule interconversion [GO:0015949] carboxy-lyase activity [GO:0016831]; orotidine-5'-phosphate decarboxylase activity [GO:0004590] GO:0004590; GO:0005737; GO:0005829; GO:0006207; GO:0015949; GO:0016831; GO:0044205 +P33022 RIHB_ECOLI Pyrimidine-specific ribonucleoside hydrolase RihB (EC 3.2.2.8) (Cytidine/uridine-specific hydrolase) rihB yeiK b2162 JW2149 yeiK rihB 33,748 protein homotetramerization [GO:0051289]; purine nucleoside catabolic process [GO:0006152]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine ribonucleoside catabolic process [GO:0046133] cytosol [GO:0005829] cytosol [GO:0005829]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; purine nucleosidase activity [GO:0008477]; uridine nucleosidase activity [GO:0045437]; protein homotetramerization [GO:0051289]; purine nucleoside catabolic process [GO:0006152]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine ribonucleoside catabolic process [GO:0046133] calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; purine nucleosidase activity [GO:0008477]; uridine nucleosidase activity [GO:0045437] GO:0005509; GO:0005829; GO:0006152; GO:0006206; GO:0008477; GO:0042802; GO:0045437; GO:0046133; GO:0051289 +P0A7I7 RIBA_ECOLI GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II) ribA b1277 JW1269 ribA 21,836 riboflavin biosynthetic process [GO:0009231] cytosol [GO:0005829] cytosol [GO:0005829]; GTP binding [GO:0005525]; GTP cyclohydrolase II activity [GO:0003935]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270]; riboflavin biosynthetic process [GO:0009231] GTP binding [GO:0005525]; GTP cyclohydrolase II activity [GO:0003935]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270] GO:0000287; GO:0003935; GO:0005525; GO:0005829; GO:0008270; GO:0009231 +P0A7Q6 RL36_ECOLI 50S ribosomal protein L36 (Large ribosomal subunit protein bL36-A) (Ribosomal protein B) rpmJ b3299 JW3261 rpmJ 4,364 translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] cytosolic large ribosomal subunit [GO:0022625]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412] structural constituent of ribosome [GO:0003735] GO:0003735; GO:0006412; GO:0022625 +P38104 RSPA_ECOLI Starvation-sensing protein RspA rspA b1581 JW1573 rspA 45,968 cellular amino acid catabolic process [GO:0009063] cellular amino acid catabolic process [GO:0009063] GO:0009063 +P27253 SCPA_ECOLI Methylmalonyl-CoA mutase (MCM) (EC 5.4.99.2) scpA sbm yliK b2917 JW2884 sbm yliK scpA 77,871 cobalamin binding [GO:0031419]; metal ion binding [GO:0046872]; methylmalonyl-CoA mutase activity [GO:0004494] cobalamin binding [GO:0031419]; metal ion binding [GO:0046872]; methylmalonyl-CoA mutase activity [GO:0004494] GO:0004494; GO:0031419; GO:0046872 +P23721 SERC_ECOLI Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) serC pdxC pdxF b0907 JW0890 pdxC pdxF serC 39,783 L-serine biosynthetic process [GO:0006564]; L-serine metabolic process [GO:0006563]; lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate [GO:0033359]; pyridoxal phosphate biosynthetic process [GO:0042823]; pyridoxine biosynthetic process [GO:0008615] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; O-phospho-L-serine:2-oxoglutarate aminotransferase activity [GO:0004648]; pyridoxal phosphate binding [GO:0030170]; L-serine biosynthetic process [GO:0006564]; L-serine metabolic process [GO:0006563]; lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate [GO:0033359]; pyridoxal phosphate biosynthetic process [GO:0042823]; pyridoxine biosynthetic process [GO:0008615] O-phospho-L-serine:2-oxoglutarate aminotransferase activity [GO:0004648]; pyridoxal phosphate binding [GO:0030170] GO:0004648; GO:0005737; GO:0005829; GO:0006563; GO:0006564; GO:0008615; GO:0030170; GO:0033359; GO:0042823 SUBCELLULAR LOCATION: Cytoplasm. +P0AGD1 SODC_ECOLI Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Bacteriocuprein) sodC b1646 JW1638 sodC 17,681 removal of superoxide radicals [GO:0019430]; superoxide metabolic process [GO:0006801] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; copper ion binding [GO:0005507]; superoxide dismutase activity [GO:0004784]; zinc ion binding [GO:0008270]; removal of superoxide radicals [GO:0019430]; superoxide metabolic process [GO:0006801] copper ion binding [GO:0005507]; superoxide dismutase activity [GO:0004784]; zinc ion binding [GO:0008270] GO:0004784; GO:0005507; GO:0006801; GO:0008270; GO:0019430; GO:0030288; GO:0042597 SUBCELLULAR LOCATION: Periplasm. +P39363 SGCA_ECOLI Putative phosphotransferase IIA component SgcA (Putative PTS system EIIA component) sgcA yjhL b4302 JW4264 yjhL sgcA 15,638 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; kinase activity [GO:0016301]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301] GO:0005737; GO:0009401; GO:0016301 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AFZ5 SULA_ECOLI Cell division inhibitor SulA sulA sfiA b0958 JW0941 sfiA sulA 18,801 cellular response to DNA damage stimulus [GO:0006974]; division septum assembly [GO:0000917]; negative regulation of cell division [GO:0051782]; negative regulation of cytokinesis [GO:0032466]; negative regulation of FtsZ-dependent cytokinesis [GO:2000245]; negative regulation of GTPase activity [GO:0034260]; negative regulation of protein polymerization [GO:0032272]; SOS response [GO:0009432] cellular response to DNA damage stimulus [GO:0006974]; division septum assembly [GO:0000917]; negative regulation of cell division [GO:0051782]; negative regulation of cytokinesis [GO:0032466]; negative regulation of FtsZ-dependent cytokinesis [GO:2000245]; negative regulation of GTPase activity [GO:0034260]; negative regulation of protein polymerization [GO:0032272]; SOS response [GO:0009432] GO:0000917; GO:0006974; GO:0009432; GO:0032272; GO:0032466; GO:0034260; GO:0051782; GO:2000245 +P0A8N3 SYK1_ECOLI Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) lysS asuD herC b2890 JW2858 asuD herC lysS 57,603 lysyl-tRNA aminoacylation [GO:0006430]; tRNA aminoacylation for protein translation [GO:0006418] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; ligase activity [GO:0016874]; lysine-tRNA ligase activity [GO:0004824]; magnesium ion binding [GO:0000287]; tRNA binding [GO:0000049]; lysyl-tRNA aminoacylation [GO:0006430]; tRNA aminoacylation for protein translation [GO:0006418] ATP binding [GO:0005524]; ligase activity [GO:0016874]; lysine-tRNA ligase activity [GO:0004824]; magnesium ion binding [GO:0000287]; tRNA binding [GO:0000049] GO:0000049; GO:0000287; GO:0004824; GO:0005524; GO:0005829; GO:0006418; GO:0006430; GO:0016020; GO:0016874 SUBCELLULAR LOCATION: Cytoplasm. +P0AG16 PUR1_ECOLI Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPATase) purF b2312 JW2309 purF 56,488 'de novo' IMP biosynthetic process [GO:0006189]; glutamine metabolic process [GO:0006541]; nucleoside metabolic process [GO:0009116]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleotide biosynthetic process [GO:0006164] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; amidophosphoribosyltransferase activity [GO:0004044]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; transferase activity, transferring glycosyl groups [GO:0016757]; 'de novo' IMP biosynthetic process [GO:0006189]; glutamine metabolic process [GO:0006541]; nucleoside metabolic process [GO:0009116]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleotide biosynthetic process [GO:0006164] amidophosphoribosyltransferase activity [GO:0004044]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; transferase activity, transferring glycosyl groups [GO:0016757] GO:0000287; GO:0004044; GO:0005737; GO:0005829; GO:0006164; GO:0006189; GO:0006541; GO:0009113; GO:0009116; GO:0016757; GO:0042802 +P75687 RCLB_ECOLI Uncharacterized protein RclB (Reactive chlorine resistance protein B) rclB ykgI b0303 JW5039 ykgI rclB 8,472 response to hypochlorite [GO:1901530] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; response to hypochlorite [GO:1901530] GO:0042597; GO:1901530 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P0A894 RAPZ_ECOLI RNase adapter protein RapZ rapZ yhbJ b3205 JW3172 yhbJ rapZ 32,492 protein homotetramerization [GO:0051289]; RNA destabilization [GO:0050779] ATP binding [GO:0005524]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; RNA binding [GO:0003723]; protein homotetramerization [GO:0051289]; RNA destabilization [GO:0050779] ATP binding [GO:0005524]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; molecular adaptor activity [GO:0060090]; RNA binding [GO:0003723] GO:0003723; GO:0005524; GO:0005525; GO:0042802; GO:0050779; GO:0051289; GO:0060090 +P36767 RDGC_ECOLI Recombination-associated protein RdgC rdgC yaiD b0393 JW0384 yaiD rdgC 33,993 DNA recombination [GO:0006310]; regulation of DNA recombination [GO:0000018] bacterial nucleoid [GO:0043590]; cytosol [GO:0005829] bacterial nucleoid [GO:0043590]; cytosol [GO:0005829]; double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697]; DNA recombination [GO:0006310]; regulation of DNA recombination [GO:0000018] double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697] GO:0000018; GO:0003690; GO:0003697; GO:0005829; GO:0006310; GO:0043590 SUBCELLULAR LOCATION: Cytoplasm, nucleoid. +P27127 RFAB_ECOLI Lipopolysaccharide 1,6-galactosyltransferase (EC 2.4.1.-) (UDP-D-galactose--(Glucosyl)lipopolysaccharide-alpha-1,3-D-galactosyltransferase) rfaB waaB b3628 JW3603 waaB rfaB 40,826 lipopolysaccharide core region biosynthetic process [GO:0009244] cytosol [GO:0005829] cytosol [GO:0005829]; lipopolysaccharide-1,6-galactosyltransferase activity [GO:0008921]; lipopolysaccharide core region biosynthetic process [GO:0009244] lipopolysaccharide-1,6-galactosyltransferase activity [GO:0008921] GO:0005829; GO:0008921; GO:0009244 +P33596 RECX_ECOLI Regulatory protein RecX (Protein OraA) recX oraA b2698 JW2668 oraA recX 19,424 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; negative regulation of catalytic activity [GO:0043086]; regulation of DNA repair [GO:0006282]; SOS response [GO:0009432] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; enzyme binding [GO:0019899]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; negative regulation of catalytic activity [GO:0043086]; regulation of DNA repair [GO:0006282]; SOS response [GO:0009432] enzyme binding [GO:0019899] GO:0005737; GO:0006281; GO:0006282; GO:0006974; GO:0009432; GO:0019899; GO:0043086 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P37634 RLMJ_ECOLI Ribosomal RNA large subunit methyltransferase J (EC 2.1.1.266) (23S rRNA (adenine(2030)-N6)-methyltransferase) (23S rRNA m6A2030 methyltransferase) rlmJ yhiR b3499 JW3466 yhiR rlmJ 31,942 carbon utilization [GO:0015976]; rRNA base methylation [GO:0070475] cytosol [GO:0005829] cytosol [GO:0005829]; 23S rRNA (adenine(2030)-N(6))-methyltransferase activity [GO:0036307]; RNA binding [GO:0003723]; rRNA (adenine-N6-)-methyltransferase activity [GO:0008988]; carbon utilization [GO:0015976]; rRNA base methylation [GO:0070475] 23S rRNA (adenine(2030)-N(6))-methyltransferase activity [GO:0036307]; RNA binding [GO:0003723]; rRNA (adenine-N6-)-methyltransferase activity [GO:0008988] GO:0003723; GO:0005829; GO:0008988; GO:0015976; GO:0036307; GO:0070475 +P0A7W1 RS5_ECOLI 30S ribosomal protein S5 (Small ribosomal subunit protein uS5) rpsE spc b3303 JW3265 spc rpsE 17,603 maintenance of translational fidelity [GO:1990145]; response to antibiotic [GO:0046677]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; maintenance of translational fidelity [GO:1990145]; response to antibiotic [GO:0046677]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GO:0000028; GO:0003735; GO:0005829; GO:0006412; GO:0019843; GO:0022627; GO:0046677; GO:1990145 +P0AEV1 RSSB_ECOLI Regulator of RpoS rssB hnr sprE ychL b1235 JW1223 hnr sprE ychL rssB 37,302 positive regulation of proteolysis [GO:0045862]; protein destabilization [GO:0031648] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; sigma factor antagonist activity [GO:0016989]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; positive regulation of proteolysis [GO:0045862]; protein destabilization [GO:0031648] DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; sigma factor antagonist activity [GO:0016989]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000976; GO:0001216; GO:0005829; GO:0016989; GO:0031648; GO:0032993; GO:0045862 +P77611 RSXC_ECOLI Ion-translocating oxidoreductase complex subunit C (EC 7.-.-.-) (Rsx electron transport complex subunit C) rsxC rnfC ydgN b1629 JW1621 rnfC ydgN rsxC 80,172 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] GO:0005886; GO:0009055; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00461}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00461}. +P0AG93 SECF_ECOLI Protein translocase subunit SecF (Sec translocon accessory complex subunit SecF) secF b0409 JW0399 secF 35,382 intracellular protein transmembrane transport [GO:0065002]; protein targeting [GO:0006605]; protein transport [GO:0015031]; protein transport by the Sec complex [GO:0043952] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; P-P-bond-hydrolysis-driven protein transmembrane transporter activity [GO:0015450]; intracellular protein transmembrane transport [GO:0065002]; protein targeting [GO:0006605]; protein transport [GO:0015031]; protein transport by the Sec complex [GO:0043952] P-P-bond-hydrolysis-driven protein transmembrane transporter activity [GO:0015450] GO:0005886; GO:0006605; GO:0015031; GO:0015450; GO:0016021; GO:0043952; GO:0065002 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0DTV7 SPEFL_ECOLI Leader peptide SpeFL (Arrest peptide SpeFL) speFL b4803 speFL 4,249 regulation of translational elongation [GO:0006448]; transcriptional attenuation by ribosome [GO:0031556] rRNA binding [GO:0019843]; regulation of translational elongation [GO:0006448]; transcriptional attenuation by ribosome [GO:0031556] rRNA binding [GO:0019843] GO:0006448; GO:0019843; GO:0031556 +P0C093 SLMA_ECOLI Nucleoid occlusion factor SlmA (Protein Ttk) (Synthetically lethal with a defective Min system protein A) slmA ttk yicB b3641 JW5641 ttk yicB slmA 22,836 division septum site selection [GO:0000918]; negative regulation of division septum assembly [GO:0010974]; negative regulation of protein polymerization [GO:0032272]; positive regulation of GTPase activity [GO:0043547]; regulation of transcription, DNA-templated [GO:0006355] bacterial nucleoid [GO:0043590]; cytoplasm [GO:0005737] bacterial nucleoid [GO:0043590]; cytoplasm [GO:0005737]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; division septum site selection [GO:0000918]; negative regulation of division septum assembly [GO:0010974]; negative regulation of protein polymerization [GO:0032272]; positive regulation of GTPase activity [GO:0043547]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000918; GO:0000976; GO:0003677; GO:0003700; GO:0005737; GO:0006355; GO:0010974; GO:0032272; GO:0042802; GO:0043547; GO:0043565; GO:0043590 SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-Rule:MF_01839, ECO:0000269|PubMed:15916962}. +P39366 SGCX_ECOLI Putative aminopeptidase SgcX (EC 3.4.11.-) sgcX yjhO b4305 JW5776 yjhO sgcX 40,615 aminopeptidase activity [GO:0004177]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] aminopeptidase activity [GO:0004177]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] GO:0004177; GO:0008237; GO:0046872 +P00957 SYA_ECOLI Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) alaS lovB b2697 JW2667 lovB alaS 96,032 alanyl-tRNA aminoacylation [GO:0006419]; negative regulation of transcription, DNA-templated [GO:0045892]; tRNA modification [GO:0006400] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; alanine-tRNA ligase activity [GO:0004813]; amino acid binding [GO:0016597]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; Ser-tRNA(Ala) hydrolase activity [GO:0002196]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]; alanyl-tRNA aminoacylation [GO:0006419]; negative regulation of transcription, DNA-templated [GO:0045892]; tRNA modification [GO:0006400] alanine-tRNA ligase activity [GO:0004813]; amino acid binding [GO:0016597]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; Ser-tRNA(Ala) hydrolase activity [GO:0002196]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] GO:0000049; GO:0001217; GO:0002161; GO:0002196; GO:0004813; GO:0005524; GO:0005829; GO:0006400; GO:0006419; GO:0008270; GO:0016020; GO:0016597; GO:0042802; GO:0045892 SUBCELLULAR LOCATION: Cytoplasm. +P0A799 PGK_ECOLI Phosphoglycerate kinase (EC 2.7.2.3) pgk b2926 JW2893 pgk 41,118 gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096] cytosol [GO:0005829] cytosol [GO:0005829]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096] ADP binding [GO:0043531]; ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618] GO:0004618; GO:0005524; GO:0005829; GO:0006094; GO:0006096; GO:0043531 SUBCELLULAR LOCATION: Cytoplasm. +P0AAE2 PROY_ECOLI Proline-specific permease ProY proY yajM b0402 JW5055 yajM proY 50,216 amino acid transmembrane transport [GO:0003333] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; amino acid transmembrane transport [GO:0003333] amino acid transmembrane transporter activity [GO:0015171] GO:0003333; GO:0005886; GO:0015171; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76161 REQ2_ECOLI Prophage antitermination protein Q homolog QuuQ (Antitermination protein Q homolog from lambdoid prophage Qin) quuQ ydfT b1559 JW1551 ydfT quuQ 27,926 regulation of transcription, DNA-templated [GO:0006355]; transcription antitermination [GO:0031564] DNA binding [GO:0003677]; regulation of transcription, DNA-templated [GO:0006355]; transcription antitermination [GO:0031564] DNA binding [GO:0003677] GO:0003677; GO:0006355; GO:0031564 +P24173 RFAC_ECOLI Lipopolysaccharide heptosyltransferase 1 (EC 2.-.-.-) rfaC rfa-2 waaC yibC b3621 JW3596 rfa-2 waaC yibC rfaC 35,544 lipopolysaccharide core region biosynthetic process [GO:0009244] cytosol [GO:0005829] cytosol [GO:0005829]; ADP-heptose-lipopolysaccharide heptosyltransferase activity [GO:0008713]; lipopolysaccharide heptosyltransferase activity [GO:0008920]; lipopolysaccharide core region biosynthetic process [GO:0009244] ADP-heptose-lipopolysaccharide heptosyltransferase activity [GO:0008713]; lipopolysaccharide heptosyltransferase activity [GO:0008920] GO:0005829; GO:0008713; GO:0008920; GO:0009244 +P0AFW0 RFAH_ECOLI Transcription antitermination protein RfaH rfaH hlyT sfrB b3842 JW3818 hlyT sfrB rfaH 18,340 positive regulation of translation [GO:0045727]; transcription antitermination [GO:0031564]; transcription elongation from bacterial-type RNA polymerase promoter [GO:0001124] bacterial-type RNA polymerase core enzyme binding [GO:0001000]; DNA binding [GO:0003677]; transcription antitermination factor activity, DNA binding [GO:0001073]; translation activator activity [GO:0008494]; positive regulation of translation [GO:0045727]; transcription antitermination [GO:0031564]; transcription elongation from bacterial-type RNA polymerase promoter [GO:0001124] bacterial-type RNA polymerase core enzyme binding [GO:0001000]; DNA binding [GO:0003677]; transcription antitermination factor activity, DNA binding [GO:0001073]; translation activator activity [GO:0008494] GO:0001000; GO:0001073; GO:0001124; GO:0003677; GO:0008494; GO:0031564; GO:0045727 +P27126 RFAS_ECOLI Lipopolysaccharide core biosynthesis protein RfaS rfaS b3629 JW3604 rfaS 36,730 lipopolysaccharide core region biosynthetic process [GO:0009244] lipopolysaccharide core region biosynthetic process [GO:0009244] GO:0009244 +P0A7Y4 RNH_ECOLI Ribonuclease HI (RNase HI) (EC 3.1.26.4) (Ribonuclease H) (RNase H) rnhA dasF herA rnh sdrA b0214 JW0204 dasF herA rnh sdrA rnhA 17,597 DNA replication, removal of RNA primer [GO:0043137]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; endonuclease activity [GO:0004519]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; DNA replication, removal of RNA primer [GO:0043137]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502] endonuclease activity [GO:0004519]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]; RNA-DNA hybrid ribonuclease activity [GO:0004523] GO:0000287; GO:0003676; GO:0004519; GO:0004523; GO:0005737; GO:0043137; GO:0090502 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P36929 RSMB_ECOLI Ribosomal RNA small subunit methyltransferase B (EC 2.1.1.176) (16S rRNA m5C967 methyltransferase) (rRNA (cytosine-C(5)-)-methyltransferase RsmB) rsmB fmu/fmv rrmB sun yhdB b3289 JW3250 fmu/fmv rrmB sun yhdB rsmB 48,348 regulation of transcription, DNA-templated [GO:0006355]; RNA methylation [GO:0001510]; rRNA base methylation [GO:0070475] cytosol [GO:0005829] cytosol [GO:0005829]; RNA binding [GO:0003723]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383]; regulation of transcription, DNA-templated [GO:0006355]; RNA methylation [GO:0001510]; rRNA base methylation [GO:0070475] RNA binding [GO:0003723]; rRNA (cytosine-C5-)-methyltransferase activity [GO:0009383] GO:0001510; GO:0003723; GO:0005829; GO:0006355; GO:0009383; GO:0070475 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P16095 SDHL_ECOLI L-serine dehydratase 1 (SDH 1) (EC 4.3.1.17) (L-serine deaminase 1) (L-SD1) sdaA b1814 JW1803 sdaA 48,907 gluconeogenesis [GO:0006094]; L-serine catabolic process [GO:0006565] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; L-serine ammonia-lyase activity [GO:0003941]; metal ion binding [GO:0046872]; gluconeogenesis [GO:0006094]; L-serine catabolic process [GO:0006565] 4 iron, 4 sulfur cluster binding [GO:0051539]; L-serine ammonia-lyase activity [GO:0003941]; metal ion binding [GO:0046872] GO:0003941; GO:0005829; GO:0006094; GO:0006565; GO:0046872; GO:0051539 +P0ACQ7 TDCA_ECOLI HTH-type transcriptional regulator TdcA (Tdc operon transcriptional activator) tdcA b3118 JW3089 tdcA 34,539 L-threonine catabolic process to propionate [GO:0070689]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; L-threonine catabolic process to propionate [GO:0070689]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700] GO:0000986; GO:0003700; GO:0005737; GO:0005829; GO:0006355; GO:0045893; GO:0070689 +P77499 SUFC_ECOLI Probable ATP-dependent transporter SufC sufC ynhD b1682 JW1672 ynhD sufC 27,582 iron-sulfur cluster assembly [GO:0016226]; response to radiation [GO:0009314] cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229] cytosol [GO:0005829]; iron-sulfur cluster assembly complex [GO:1990229]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; iron-sulfur cluster assembly [GO:0016226]; response to radiation [GO:0009314] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005829; GO:0009314; GO:0016226; GO:0042626; GO:1990229 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12554644}. +P0AGE0 SSB_ECOLI Single-stranded DNA-binding protein (SSB) (Helix-destabilizing protein) ssb exrB lexC b4059 JW4020 exrB lexC ssb 18,975 DNA replication [GO:0006260]; mismatch repair [GO:0006298]; positive regulation of catalytic activity [GO:0043085]; positive regulation of helicase activity [GO:0051096]; recombinational repair [GO:0000725]; SOS response [GO:0009432] cytosol [GO:0005829]; nucleoid [GO:0009295] cytosol [GO:0005829]; nucleoid [GO:0009295]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697]; DNA replication [GO:0006260]; mismatch repair [GO:0006298]; positive regulation of catalytic activity [GO:0043085]; positive regulation of helicase activity [GO:0051096]; recombinational repair [GO:0000725]; SOS response [GO:0009432] enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697] GO:0000725; GO:0003697; GO:0005829; GO:0006260; GO:0006298; GO:0008047; GO:0009295; GO:0009432; GO:0042802; GO:0043085; GO:0051096 +P45581 STFP_ECOLI Uncharacterized protein StfP (Uncharacterized protein StfP from lambdoid prophage e14 region) stfP ycfK b1154 JW1140 ycfK stfP 22,020 +P77515 STFQ_ECOLI Prophage side tail fiber protein homolog StfQ (Side tail fiber protein homolog from lambdoid prophage Qin) stfQ ydfN b1547 JW1540 ydfN stfQ 32,902 structural molecule activity [GO:0005198] structural molecule activity [GO:0005198] GO:0005198 +P69831 PTKC_ECOLI PTS system galactitol-specific EIIC component (EIIC-Gat) (Galactitol permease IIC component) gatC b2092 JW2076 gatC 48,365 galactitol metabolic process [GO:0019402]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; galactitol transmembrane transporter activity [GO:0015577]; galactitol metabolic process [GO:0019402]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] galactitol transmembrane transporter activity [GO:0015577] GO:0005886; GO:0009401; GO:0015577; GO:0016021; GO:0019402 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00427, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00427, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:16079137}. +Q2EEQ2 RL362_ECOLI 50S ribosomal protein L36 2 (Large ribosomal subunit protein bL36-B) ykgO rpmJ2 b4506 JW5034 rpmJ2 ykgO 5,467 translation [GO:0006412] ribosome [GO:0005840] ribosome [GO:0005840]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412] structural constituent of ribosome [GO:0003735] GO:0003735; GO:0005840; GO:0006412 +P0AG51 RL30_ECOLI 50S ribosomal protein L30 (Large ribosomal subunit protein uL30) rpmD b3302 JW3264 rpmD 6,542 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625] cytosolic large ribosomal subunit [GO:0022625]; structural constituent of ribosome [GO:0003735]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] structural constituent of ribosome [GO:0003735] GO:0000027; GO:0003735; GO:0006412; GO:0022625 +P0A7Q1 RL35_ECOLI 50S ribosomal protein L35 (Large ribosomal subunit protein bL35) (Ribosomal protein A) rpmI b1717 JW1707 rpmI 7,289 translation [GO:0006412] cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934] cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412] structural constituent of ribosome [GO:0003735] GO:0003735; GO:0006412; GO:0015934; GO:0022625 +P0A7W7 RS8_ECOLI 30S ribosomal protein S8 (Small ribosomal subunit protein uS8) rpsH b3306 JW3268 rpsH 14,127 regulation of mRNA stability [GO:0043488]; regulation of translation [GO:0006417]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; regulation of mRNA stability [GO:0043488]; regulation of translation [GO:0006417]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735] GO:0000028; GO:0003735; GO:0005829; GO:0006412; GO:0006417; GO:0019843; GO:0022627; GO:0043488 +P30744 SDHM_ECOLI L-serine dehydratase 2 (SDH 2) (EC 4.3.1.17) (L-serine deaminase 2) (L-SD2) sdaB b2797 JW2768 sdaB 48,753 gluconeogenesis [GO:0006094]; L-serine catabolic process [GO:0006565] 4 iron, 4 sulfur cluster binding [GO:0051539]; L-serine ammonia-lyase activity [GO:0003941]; metal ion binding [GO:0046872]; gluconeogenesis [GO:0006094]; L-serine catabolic process [GO:0006565] 4 iron, 4 sulfur cluster binding [GO:0051539]; L-serine ammonia-lyase activity [GO:0003941]; metal ion binding [GO:0046872] GO:0003941; GO:0006094; GO:0006565; GO:0046872; GO:0051539 +P0AGA2 SECY_ECOLI Protein translocase subunit SecY secY prlA b3300 JW3262 prlA secY 48,512 intracellular protein transmembrane transport [GO:0065002]; intracellular protein transport [GO:0006886]; protein insertion into membrane from inner side [GO:0032978]; protein transport by the Sec complex [GO:0043952]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616] cell envelope Sec protein transport complex [GO:0031522]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cell envelope Sec protein transport complex [GO:0031522]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; protein transmembrane transporter activity [GO:0008320]; signal sequence binding [GO:0005048]; intracellular protein transmembrane transport [GO:0065002]; intracellular protein transport [GO:0006886]; protein insertion into membrane from inner side [GO:0032978]; protein transport by the Sec complex [GO:0043952]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616] protein transmembrane transporter activity [GO:0008320]; signal sequence binding [GO:0005048] GO:0005048; GO:0005886; GO:0005887; GO:0006616; GO:0006886; GO:0008320; GO:0016021; GO:0031522; GO:0032978; GO:0043952; GO:0065002 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P38392 SIEB_ECOLI Superinfection exclusion protein B sieB b1353 JW5209 sieB 19,244 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P31122 SOTB_ECOLI Sugar efflux transporter sotB ydeA b1528 JW1521 ydeA sotB 42,538 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; carbohydrate transmembrane transporter activity [GO:0015144] carbohydrate transmembrane transporter activity [GO:0015144] GO:0005886; GO:0015144; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +C1P5Z7 SGRT_ECOLI Putative inhibitor of glucose uptake transporter SgrT sgrT b4662 JW0068.1 sgrT 5,338 negative regulation of glucose import [GO:0046325]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] enzyme inhibitor activity [GO:0004857]; negative regulation of glucose import [GO:0046325]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] enzyme inhibitor activity [GO:0004857] GO:0004857; GO:0009401; GO:0046325 +P0A8M3 SYT_ECOLI Threonine--tRNA ligase (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) thrS b1719 JW1709 thrS 74,014 negative regulation of translational initiation [GO:0045947]; regulation of translation [GO:0006417]; response to antibiotic [GO:0046677]; threonyl-tRNA aminoacylation [GO:0006435]; tRNA aminoacylation [GO:0043039]; tRNA aminoacylation for protein translation [GO:0006418] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; aminoacyl-tRNA editing activity [GO:0002161]; aminoacyl-tRNA ligase activity [GO:0004812]; ATP binding [GO:0005524]; drug binding [GO:0008144]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; threonine-tRNA ligase activity [GO:0004829]; translation repressor activity, mRNA regulatory element binding [GO:0000900]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]; negative regulation of translational initiation [GO:0045947]; regulation of translation [GO:0006417]; response to antibiotic [GO:0046677]; threonyl-tRNA aminoacylation [GO:0006435]; tRNA aminoacylation [GO:0043039]; tRNA aminoacylation for protein translation [GO:0006418] aminoacyl-tRNA editing activity [GO:0002161]; aminoacyl-tRNA ligase activity [GO:0004812]; ATP binding [GO:0005524]; drug binding [GO:0008144]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; threonine-tRNA ligase activity [GO:0004829]; translation repressor activity, mRNA regulatory element binding [GO:0000900]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270] GO:0000049; GO:0000900; GO:0002161; GO:0003723; GO:0004812; GO:0004829; GO:0005524; GO:0005737; GO:0005829; GO:0006417; GO:0006418; GO:0006435; GO:0008144; GO:0008270; GO:0043039; GO:0045947; GO:0046677; GO:0048027 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00184}. +Q47538 TAUB_ECOLI Taurine import ATP-binding protein TauB (EC 7.6.2.7) tauB ssiB yaiQ b0366 JW0358 ssiB yaiQ tauB 28,297 cellular response to sulfur starvation [GO:0010438] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cellular response to sulfur starvation [GO:0010438] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0010438; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01714}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01714}. +P0AFI0 OXC_ECOLI Oxalyl-CoA decarboxylase (EC 4.1.1.8) oxc yfdU b2373 JW2370 yfdU oxc 60,581 cellular response to acidic pH [GO:0071468]; fatty acid alpha-oxidation [GO:0001561]; oxalate catabolic process [GO:0033611] ADP binding [GO:0043531]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; oxalyl-CoA decarboxylase activity [GO:0008949]; thiamine pyrophosphate binding [GO:0030976]; cellular response to acidic pH [GO:0071468]; fatty acid alpha-oxidation [GO:0001561]; oxalate catabolic process [GO:0033611] ADP binding [GO:0043531]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; oxalyl-CoA decarboxylase activity [GO:0008949]; thiamine pyrophosphate binding [GO:0030976] GO:0000287; GO:0001561; GO:0008949; GO:0030976; GO:0033611; GO:0042802; GO:0043531; GO:0071468 +P05459 PDXB_ECOLI Erythronate-4-phosphate dehydrogenase (EC 1.1.1.290) pdxB b2320 JW2317 pdxB 41,368 'de novo' pyridoxal 5'-phosphate biosynthetic process [GO:0036001]; pyridoxine biosynthetic process [GO:0008615] cytosol [GO:0005829] cytosol [GO:0005829]; 4-phosphoerythronate dehydrogenase activity [GO:0033711]; NAD binding [GO:0051287]; protein dimerization activity [GO:0046983]; 'de novo' pyridoxal 5'-phosphate biosynthetic process [GO:0036001]; pyridoxine biosynthetic process [GO:0008615] 4-phosphoerythronate dehydrogenase activity [GO:0033711]; NAD binding [GO:0051287]; protein dimerization activity [GO:0046983] GO:0005829; GO:0008615; GO:0033711; GO:0036001; GO:0046983; GO:0051287 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01825}. +P0A7H0 RECF_ECOLI DNA replication and repair protein RecF recF uvrF b3700 JW3677 uvrF recF 40,514 DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; response to radiation [GO:0009314]; response to UV [GO:0009411]; SOS response [GO:0009432] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; single-stranded DNA binding [GO:0003697]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; response to radiation [GO:0009314]; response to UV [GO:0009411]; SOS response [GO:0009432] ATP binding [GO:0005524]; single-stranded DNA binding [GO:0003697] GO:0000731; GO:0003697; GO:0005524; GO:0005829; GO:0006260; GO:0006302; GO:0009314; GO:0009411; GO:0009432 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P0A7I4 RF3_ECOLI Peptide chain release factor RF3 (RF-3) prfC miaD tos b4375 JW5873 miaD tos prfC 59,574 regulation of translational termination [GO:0006449]; translational termination [GO:0006415] cytosol [GO:0005829] cytosol [GO:0005829]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation release factor activity, codon nonspecific [GO:0016150]; translation release factor activity, codon specific [GO:0016149]; regulation of translational termination [GO:0006449]; translational termination [GO:0006415] GDP binding [GO:0019003]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; translation release factor activity, codon nonspecific [GO:0016150]; translation release factor activity, codon specific [GO:0016149] GO:0003924; GO:0005525; GO:0005829; GO:0006415; GO:0006449; GO:0016149; GO:0016150; GO:0019003 SUBCELLULAR LOCATION: Cytoplasm. +P25539 RIBD_ECOLI Riboflavin biosynthesis protein RibD [Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase (DRAP deaminase) (EC 3.5.4.26) (Riboflavin-specific deaminase); 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) (HTP reductase)] ribD ribG ybaE b0414 JW0404 ribG ybaE ribD 40,338 riboflavin biosynthetic process [GO:0009231] 5-amino-6-(5-phosphoribosylamino)uracil reductase activity [GO:0008703]; diaminohydroxyphosphoribosylaminopyrimidine deaminase activity [GO:0008835]; NADP binding [GO:0050661]; zinc ion binding [GO:0008270]; riboflavin biosynthetic process [GO:0009231] 5-amino-6-(5-phosphoribosylamino)uracil reductase activity [GO:0008703]; diaminohydroxyphosphoribosylaminopyrimidine deaminase activity [GO:0008835]; NADP binding [GO:0050661]; zinc ion binding [GO:0008270] GO:0008270; GO:0008703; GO:0008835; GO:0009231; GO:0050661 +P07648 RECC_ECOLI RecBCD enzyme subunit RecC (EC 3.1.11.5) (Exodeoxyribonuclease V 125 kDa polypeptide) (Exodeoxyribonuclease V gamma chain) (Exonuclease V subunit RecC) (ExoV subunit RecC) recC b2822 JW2790 recC 128,848 clearance of foreign intracellular DNA [GO:0044355]; DNA recombination [GO:0006310]; double-strand break repair via homologous recombination [GO:0000724]; response to radiation [GO:0009314] exodeoxyribonuclease V complex [GO:0009338] exodeoxyribonuclease V complex [GO:0009338]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; exodeoxyribonuclease V activity [GO:0008854]; clearance of foreign intracellular DNA [GO:0044355]; DNA recombination [GO:0006310]; double-strand break repair via homologous recombination [GO:0000724]; response to radiation [GO:0009314] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; exodeoxyribonuclease V activity [GO:0008854] GO:0000724; GO:0003677; GO:0003678; GO:0005524; GO:0006310; GO:0008854; GO:0009314; GO:0009338; GO:0044355 +P76104 RLHA_ECOLI 23S rRNA 5-hydroxycytidine C2501 synthase (Large subunit ribosomal RNA hydroxylation A) rlhA ydcP b1435 JW1431 ydcP rlhA 72,702 rRNA modification [GO:0000154] rRNA modification [GO:0000154] GO:0000154 +P13445 RPOS_ECOLI RNA polymerase sigma factor RpoS (Sigma S) (Sigma-38) rpoS appR katF nur otsX sigS b2741 JW5437 appR katF nur otsX sigS rpoS 37,972 transcription initiation from bacterial-type RNA polymerase promoter [GO:0001123] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; bacterial-type RNA polymerase core enzyme binding [GO:0001000]; DNA binding [GO:0003677]; sigma factor activity [GO:0016987]; transcription initiation from bacterial-type RNA polymerase promoter [GO:0001123] bacterial-type RNA polymerase core enzyme binding [GO:0001000]; DNA binding [GO:0003677]; sigma factor activity [GO:0016987] GO:0001000; GO:0001123; GO:0003677; GO:0005737; GO:0016987 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00959}. +P46849 RTCA_ECOLI RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) rtcA yhgJ yhgK b4475 JW5688 yhgJ yhgK rtcA 35,903 RNA processing [GO:0006396] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; RNA-3'-phosphate cyclase activity [GO:0003963]; RNA processing [GO:0006396] ATP binding [GO:0005524]; RNA-3'-phosphate cyclase activity [GO:0003963] GO:0003963; GO:0005524; GO:0005737; GO:0006396 SUBCELLULAR LOCATION: Cytoplasm. +P77223 RSXB_ECOLI Ion-translocating oxidoreductase complex subunit B (EC 7.-.-.-) (Rsx electron transport complex subunit B) rsxB rnfB ydgM b1628 JW1620 rnfB ydgM rsxB 20,544 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] GO:0005886; GO:0009055; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00463}. +P0AFY2 SANA_ECOLI Protein SanA sanA yeiF b2144 JW2132 yeiF sanA 27,287 response to drug [GO:0042493] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; response to drug [GO:0042493] GO:0005886; GO:0016021; GO:0042493 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein. +P0AFY6 SBMA_ECOLI Peptide antibiotic transporter SbmA sbmA b0377 JW0368 sbmA 46,459 microcin B17 transport [GO:0042885]; microcin transport [GO:0042884]; peptide transport [GO:0015833]; protein transport [GO:0015031]; response to antibiotic [GO:0046677]; toxin transport [GO:1901998] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; microcin transmembrane transporter activity [GO:0015638]; peptide transmembrane transporter activity [GO:1904680]; secondary active transmembrane transporter activity [GO:0015291]; toxin transmembrane transporter activity [GO:0019534]; microcin B17 transport [GO:0042885]; microcin transport [GO:0042884]; peptide transport [GO:0015833]; protein transport [GO:0015031]; response to antibiotic [GO:0046677]; toxin transport [GO:1901998] ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; microcin transmembrane transporter activity [GO:0015638]; peptide transmembrane transporter activity [GO:1904680]; secondary active transmembrane transporter activity [GO:0015291]; toxin transmembrane transporter activity [GO:0019534] GO:0005524; GO:0005886; GO:0005887; GO:0015031; GO:0015291; GO:0015638; GO:0015833; GO:0016887; GO:0019534; GO:0042626; GO:0042884; GO:0042885; GO:0046677; GO:1901998; GO:1904680 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P33026 SETB_ECOLI Sugar efflux transporter B setB yeiO b2170 JW2157 yeiO setB 42,746 carbohydrate transmembrane transport [GO:0034219]; cellular response to glucose-phosphate stress [GO:0036448]; chromosome segregation [GO:0007059]; glucose transmembrane transport [GO:1904659]; lactose transport [GO:0015767]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; carbohydrate:proton symporter activity [GO:0005351]; carbohydrate transmembrane transport [GO:0034219]; cellular response to glucose-phosphate stress [GO:0036448]; chromosome segregation [GO:0007059]; glucose transmembrane transport [GO:1904659]; lactose transport [GO:0015767]; transmembrane transport [GO:0055085] carbohydrate:proton symporter activity [GO:0005351] GO:0005351; GO:0005886; GO:0007059; GO:0015767; GO:0016020; GO:0016021; GO:0034219; GO:0036448; GO:0055085; GO:1904659 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P39365 SGCC_ECOLI Putative permease IIC component (Putative PTS system EIIC component) sgcC yjhN b4304 JW4266 yjhN sgcC 46,684 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; galactitol transmembrane transporter activity [GO:0015577]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] galactitol transmembrane transporter activity [GO:0015577] GO:0005886; GO:0009401; GO:0015577; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00427, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00427, ECO:0000269|PubMed:15919996}. +P0C0K3 SRKA_ECOLI Stress response kinase A (EC 2.7.11.1) (Serine/threonine protein kinase YihE) (Serine/threonine-protein kinase SrkA) srkA rdoA yihE b3859 JW3831 rdoA yihE srkA 38,120 cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein threonine kinase activity [GO:0106311] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674]; protein serine kinase activity [GO:0106310]; protein threonine kinase activity [GO:0106311] GO:0000287; GO:0004674; GO:0005524; GO:0005737; GO:0106310; GO:0106311 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01497, ECO:0000305|PubMed:17302814}. +P77667 SUFA_ECOLI Protein SufA sufA ydiC b1684 JW1674 ydiC sufA 13,300 iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; 2 iron, 2 sulfur cluster binding [GO:0051537]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; response to oxidative stress [GO:0006979] 2 iron, 2 sulfur cluster binding [GO:0051537] GO:0005737; GO:0005829; GO:0006979; GO:0016226; GO:0051537; GO:0097428 +Q57261 TRUD_ECOLI tRNA pseudouridine synthase D (EC 5.4.99.27) (tRNA pseudouridine(13) synthase) (tRNA pseudouridylate synthase D) (tRNA-uridine isomerase D) truD ygbO b2745 JW2715 ygbO truD 39,091 pseudouridine synthesis [GO:0001522]; tRNA pseudouridine synthesis [GO:0031119] cytosol [GO:0005829] cytosol [GO:0005829]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine synthase activity [GO:0106029]; pseudouridine synthesis [GO:0001522]; tRNA pseudouridine synthesis [GO:0031119] pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine synthase activity [GO:0106029] GO:0001522; GO:0003723; GO:0005829; GO:0009982; GO:0031119; GO:0106029 +P17443 MURG_ECOLI UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase) murG b0090 JW0088 murG 37,815 carbohydrate metabolic process [GO:0005975]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; lipid glycosylation [GO:0030259]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity [GO:0051991]; undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity [GO:0050511]; carbohydrate metabolic process [GO:0005975]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; lipid glycosylation [GO:0030259]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity [GO:0051991]; undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity [GO:0050511] GO:0005886; GO:0005975; GO:0007049; GO:0008360; GO:0009252; GO:0030259; GO:0050511; GO:0051301; GO:0051991; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00033, ECO:0000269|PubMed:1649817, ECO:0000269|PubMed:17640276, ECO:0000269|PubMed:8449890}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00033, ECO:0000269|PubMed:1649817, ECO:0000269|PubMed:17640276, ECO:0000269|PubMed:8449890}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_00033, ECO:0000269|PubMed:8449890}. Note=Randomly distributed in the cell envelope with a higher intensity at the division site. Mid-cell localization requires divisome components. {ECO:0000269|PubMed:17640276}. +P16689 PHNM_ECOLI Alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase (RPnTP diphosphatase) (EC 3.6.1.63) phnM b4095 JW4056 phnM 42,010 organic phosphonate catabolic process [GO:0019700] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]; organic phosphonate catabolic process [GO:0019700] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810] GO:0016810; GO:0019700 +P76038 PUUD_ECOLI Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD (Gamma-Glu-GABA hydrolase) (EC 3.5.1.94) puuD ycjL b1298 JW1291 ycjL puuD 28,013 polyamine catabolic process [GO:0006598]; putrescine catabolic process [GO:0009447] gamma-glutamyl-gamma-aminobutyrate hydrolase activity [GO:0033969]; polyamine catabolic process [GO:0006598]; putrescine catabolic process [GO:0009447] gamma-glutamyl-gamma-aminobutyrate hydrolase activity [GO:0033969] GO:0006598; GO:0009447; GO:0033969 +P77756 QUEC_ECOLI 7-cyano-7-deazaguanine synthase (EC 6.3.4.20) (7-cyano-7-carbaguanine synthase) (PreQ(0) synthase) (Queuosine biosynthesis protein QueC) queC ybaX b0444 JW0434 ybaX queC 25,514 queuosine biosynthetic process [GO:0008616] ATP binding [GO:0005524]; ligase activity, forming carbon-nitrogen bonds [GO:0016879]; zinc ion binding [GO:0008270]; queuosine biosynthetic process [GO:0008616] ATP binding [GO:0005524]; ligase activity, forming carbon-nitrogen bonds [GO:0016879]; zinc ion binding [GO:0008270] GO:0005524; GO:0008270; GO:0008616; GO:0016879 +P37051 PURU_ECOLI Formyltetrahydrofolate deformylase (EC 3.5.1.10) (Formyl-FH(4) hydrolase) purU tgs ychI b1232 JW1220 tgs ychI purU 31,935 'de novo' IMP biosynthetic process [GO:0006189]; 10-formyltetrahydrofolate biosynthetic process [GO:0009257]; one-carbon metabolic process [GO:0006730]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleotide biosynthetic process [GO:0009152] cytosol [GO:0005829] cytosol [GO:0005829]; formyltetrahydrofolate deformylase activity [GO:0008864]; hydroxymethyl-, formyl- and related transferase activity [GO:0016742]; 'de novo' IMP biosynthetic process [GO:0006189]; 10-formyltetrahydrofolate biosynthetic process [GO:0009257]; one-carbon metabolic process [GO:0006730]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleotide biosynthetic process [GO:0009152] formyltetrahydrofolate deformylase activity [GO:0008864]; hydroxymethyl-, formyl- and related transferase activity [GO:0016742] GO:0005829; GO:0006164; GO:0006189; GO:0006730; GO:0008864; GO:0009152; GO:0009257; GO:0016742 +P16917 RHSB_ECOLI Protein RhsB rhsB b3482 JW5679 rhsB 159,395 +P24255 RP54_ECOLI RNA polymerase sigma-54 factor rpoN glnF ntrA b3202 JW3169 glnF ntrA rpoN 53,990 arginine metabolic process [GO:0006525]; DNA-templated transcription, initiation [GO:0006352] protein-DNA complex [GO:0032993] protein-DNA complex [GO:0032993]; DNA-binding transcription activator activity [GO:0001216]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; sigma factor activity [GO:0016987]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; arginine metabolic process [GO:0006525]; DNA-templated transcription, initiation [GO:0006352] DNA-binding transcription activator activity [GO:0001216]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; sigma factor activity [GO:0016987]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0001216; GO:0003899; GO:0006352; GO:0006525; GO:0016987; GO:0032993 +P75895 RUTD_ECOLI Putative aminoacrylate hydrolase RutD (EC 3.5.1.-) (Aminohydrolase) rutD ycdJ b1009 JW0994 ycdJ rutD 28,898 nitrogen utilization [GO:0019740]; pyrimidine nucleobase catabolic process [GO:0006208]; uracil catabolic process [GO:0006212] hydrolase activity [GO:0016787]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; nitrogen utilization [GO:0019740]; pyrimidine nucleobase catabolic process [GO:0006208]; uracil catabolic process [GO:0006212] hydrolase activity [GO:0016787]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811] GO:0006208; GO:0006212; GO:0016787; GO:0016811; GO:0019740 +P76350 SHIA_ECOLI Shikimate transporter shiA yeeM b1981 JW1962 yeeM shiA 47,817 shikimate transmembrane transport [GO:0015733] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; shikimate transmembrane transporter activity [GO:0015530]; symporter activity [GO:0015293]; shikimate transmembrane transport [GO:0015733] shikimate transmembrane transporter activity [GO:0015530]; symporter activity [GO:0015293] GO:0005886; GO:0015293; GO:0015530; GO:0015733; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +C1P611 SHOB_ECOLI Small toxic protein ShoB shoB ryfB yphI b4687 JW2546.1 ryfB yphI shoB 3,103 programmed cell death [GO:0012501] integral component of membrane [GO:0016021] integral component of membrane [GO:0016021]; programmed cell death [GO:0012501] GO:0012501; GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P16688 PHNJ_ECOLI Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase (PRPn C-P lyase) (EC 4.7.1.1) phnJ b4098 JW4059 phnJ 31,845 organic phosphonate catabolic process [GO:0019700] carbon phosphorus lyase complex [GO:1904176] carbon phosphorus lyase complex [GO:1904176]; 4 iron, 4 sulfur cluster binding [GO:0051539]; alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity [GO:0098848]; lyase activity [GO:0016829]; metal ion binding [GO:0046872]; organic phosphonate catabolic process [GO:0019700] 4 iron, 4 sulfur cluster binding [GO:0051539]; alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity [GO:0098848]; lyase activity [GO:0016829]; metal ion binding [GO:0046872] GO:0016829; GO:0019700; GO:0046872; GO:0051539; GO:0098848; GO:1904176 +P06999 PFKB_ECOLI ATP-dependent 6-phosphofructokinase isozyme 2 (ATP-PFK 2) (Phosphofructokinase 2) (EC 2.7.1.11) (6-phosphofructokinase isozyme II) (Phosphohexokinase 2) pfkB b1723 JW5280 pfkB 32,456 cellular response to DNA damage stimulus [GO:0006974]; glycolytic process [GO:0006096] cytosol [GO:0005829] cytosol [GO:0005829]; 6-phosphofructokinase activity [GO:0003872]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phosphofructokinase activity [GO:0008443]; tagatose-6-phosphate kinase activity [GO:0009024]; cellular response to DNA damage stimulus [GO:0006974]; glycolytic process [GO:0006096] 6-phosphofructokinase activity [GO:0003872]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phosphofructokinase activity [GO:0008443]; tagatose-6-phosphate kinase activity [GO:0009024] GO:0000287; GO:0003872; GO:0005524; GO:0005829; GO:0006096; GO:0006974; GO:0008443; GO:0009024; GO:0042802 +P0A7R5 RS10_ECOLI 30S ribosomal protein S10 (Small ribosomal subunit protein uS10) (Transcription termination/antitermination protein NusE) rpsJ nusE b3321 JW3283 nusE rpsJ 11,736 ribosome biogenesis [GO:0042254]; transcription antitermination [GO:0031564]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935]; structural constituent of ribosome [GO:0003735]; transcription antitermination factor activity, RNA binding [GO:0001072]; tRNA binding [GO:0000049]; ribosome biogenesis [GO:0042254]; transcription antitermination [GO:0031564]; translation [GO:0006412] structural constituent of ribosome [GO:0003735]; transcription antitermination factor activity, RNA binding [GO:0001072]; tRNA binding [GO:0000049] GO:0000049; GO:0001072; GO:0003735; GO:0005829; GO:0006412; GO:0015935; GO:0022627; GO:0031564; GO:0042254 +P0A7U7 RS20_ECOLI 30S ribosomal protein S20 (Small ribosomal subunit protein bS20) rpsT b0023 JW0022 rpsT 9,684 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935]; ornithine decarboxylase inhibitor activity [GO:0008073]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] ornithine decarboxylase inhibitor activity [GO:0008073]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735] GO:0000028; GO:0003735; GO:0005829; GO:0006412; GO:0008073; GO:0015935; GO:0022627; GO:0070181 +P75892 RUTG_ECOLI Putative pyrimidine permease RutG rutG ycdG b1006 JW5137 ycdG rutG 45,557 pyrimidine nucleobase transmembrane transport [GO:1904082]; uracil catabolic process [GO:0006212]; uracil import across plasma membrane [GO:0098721] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; pyrimidine nucleobase transmembrane transporter activity [GO:0005350]; pyrimidine nucleotide transmembrane transporter activity [GO:0015218]; uracil transmembrane transporter activity [GO:0015210]; uracil:cation symporter activity [GO:0015505]; pyrimidine nucleobase transmembrane transport [GO:1904082]; uracil catabolic process [GO:0006212]; uracil import across plasma membrane [GO:0098721] pyrimidine nucleobase transmembrane transporter activity [GO:0005350]; pyrimidine nucleotide transmembrane transporter activity [GO:0015218]; uracil:cation symporter activity [GO:0015505]; uracil transmembrane transporter activity [GO:0015210] GO:0005350; GO:0005886; GO:0006212; GO:0015210; GO:0015218; GO:0015505; GO:0016021; GO:0098721; GO:1904082 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AAD6 SDAC_ECOLI Serine transporter sdaC dcrA b2796 JW2767 dcrA sdaC 46,906 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171] amino acid transmembrane transporter activity [GO:0015171] GO:0005886; GO:0005887; GO:0015171 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AG86 SECB_ECOLI Protein-export protein SecB (Chaperone SecB) secB b3609 JW3584 secB 17,277 chaperone-mediated protein transport [GO:0072321]; protein folding [GO:0006457]; protein localization [GO:0008104]; protein targeting [GO:0006605]; protein tetramerization [GO:0051262]; protein transport [GO:0015031]; protein transport by the Sec complex [GO:0043952] cytosol [GO:0005829] cytosol [GO:0005829]; preprotein binding [GO:0070678]; unfolded protein binding [GO:0051082]; chaperone-mediated protein transport [GO:0072321]; protein folding [GO:0006457]; protein localization [GO:0008104]; protein targeting [GO:0006605]; protein tetramerization [GO:0051262]; protein transport [GO:0015031]; protein transport by the Sec complex [GO:0043952] preprotein binding [GO:0070678]; unfolded protein binding [GO:0051082] GO:0005829; GO:0006457; GO:0006605; GO:0008104; GO:0015031; GO:0043952; GO:0051082; GO:0051262; GO:0070678; GO:0072321 SUBCELLULAR LOCATION: Cytoplasm. +P0AAI1 SSUB_ECOLI Aliphatic sulfonates import ATP-binding protein SsuB (EC 7.6.2.14) ssuB ycbE b0933 JW0916 ycbE ssuB 27,738 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; alkanesulfonate transmembrane transporter activity [GO:0042959]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626] alkanesulfonate transmembrane transporter activity [GO:0042959]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0042626; GO:0042959 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01724}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01724}. +P05707 SRLD_ECOLI Sorbitol-6-phosphate 2-dehydrogenase (EC 1.1.1.140) (Glucitol-6-phosphate dehydrogenase) (Ketosephosphate reductase) srlD gutD b2705 JW2674 gutD srlD 27,858 sorbitol catabolic process [GO:0006062] identical protein binding [GO:0042802]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; sorbitol-6-phosphate 2-dehydrogenase activity [GO:0009010]; sorbitol catabolic process [GO:0006062] identical protein binding [GO:0042802]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; sorbitol-6-phosphate 2-dehydrogenase activity [GO:0009010] GO:0006062; GO:0009010; GO:0016616; GO:0042802 +P0A832 SSRP_ECOLI SsrA-binding protein (Small protein B) smpB smqB b2620 JW2601 smqB smpB 18,269 trans-translation [GO:0070929]; trans-translation-dependent protein tagging [GO:0070930] cytosol [GO:0005829] cytosol [GO:0005829]; RNA binding [GO:0003723]; trans-translation [GO:0070929]; trans-translation-dependent protein tagging [GO:0070930] RNA binding [GO:0003723] GO:0003723; GO:0005829; GO:0070929; GO:0070930 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00023, ECO:0000269|PubMed:11917023, ECO:0000269|PubMed:15069072}. Note=The tmRNA-SmpB complex associates with stalled ribosomes (PubMed:10393194, PubMed:11917023, PubMed:15699355, PubMed:20940705, PubMed:22622583). SmpB associates with ribosomes even in the absence of tmRNA (PubMed:15069072). {ECO:0000255|HAMAP-Rule:MF_00023, ECO:0000269|PubMed:10393194, ECO:0000269|PubMed:11917023, ECO:0000269|PubMed:15069072, ECO:0000269|PubMed:15699355, ECO:0000269|PubMed:20940705, ECO:0000269|PubMed:22622583}. +P77754 SPY_ECOLI Periplasmic chaperone Spy (Spheroplast protein Y) spy b1743 JW1732 spy 18,199 ATP-independent chaperone mediated protein folding [GO:1990507]; chaperone-mediated protein folding [GO:0061077]; response to organic cyclic compound [GO:0014070] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; unfolded protein binding [GO:0051082]; ATP-independent chaperone mediated protein folding [GO:1990507]; chaperone-mediated protein folding [GO:0061077]; response to organic cyclic compound [GO:0014070] unfolded protein binding [GO:0051082] GO:0014070; GO:0030288; GO:0051082; GO:0061077; GO:1990507 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:21317898, ECO:0000269|PubMed:9068658, ECO:0000269|PubMed:9694902}. +P76072 STFR_ECOLI Prophage side tail fiber protein homolog StfR (Side tail fiber protein homolog from lambdoid prophage Rac) stfR ynaB b1372 JW1366 ynaB stfR 113,780 structural molecule activity [GO:0005198] structural molecule activity [GO:0005198] GO:0005198 +P0ABZ6 SURA_ECOLI Chaperone SurA (Peptidyl-prolyl cis-trans isomerase SurA) (PPIase SurA) (EC 5.2.1.8) (Rotamase SurA) (Survival protein A) surA b0053 JW0052 surA 47,284 chaperone-mediated protein folding [GO:0061077]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; maintenance of stationary phase [GO:0060274]; protein folding [GO:0006457]; protein stabilization [GO:0050821] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; peptide binding [GO:0042277]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; unfolded protein binding [GO:0051082]; chaperone-mediated protein folding [GO:0061077]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; maintenance of stationary phase [GO:0060274]; protein folding [GO:0006457]; protein stabilization [GO:0050821] peptide binding [GO:0042277]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; unfolded protein binding [GO:0051082] GO:0003755; GO:0006457; GO:0030288; GO:0042277; GO:0043165; GO:0050821; GO:0051082; GO:0060274; GO:0061077 SUBCELLULAR LOCATION: Periplasm. Note=Is capable of associating with the outer membrane. +P27859 TATD_ECOLI 3'-5' ssDNA/RNA exonuclease TatD (EC 3.1.11.-) (EC 3.1.13.-) (DNase TatD) tatD mttC yigW yigX b4483 JW5931 mttC yigW yigX tatD 28,974 DNA catabolic process, exonucleolytic [GO:0000738]; response to hydrogen peroxide [GO:0042542]; RNA phosphodiester bond hydrolysis [GO:0090501] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; 3'-5'-exoribonuclease activity [GO:0000175]; deoxyribonuclease activity [GO:0004536]; endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; single-stranded DNA 3'-5' exodeoxyribonuclease activity [GO:0008310]; DNA catabolic process, exonucleolytic [GO:0000738]; response to hydrogen peroxide [GO:0042542]; RNA phosphodiester bond hydrolysis [GO:0090501] 3'-5'-exoribonuclease activity [GO:0000175]; deoxyribonuclease activity [GO:0004536]; endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; single-stranded DNA 3'-5' exodeoxyribonuclease activity [GO:0008310] GO:0000175; GO:0000287; GO:0000738; GO:0004536; GO:0005737; GO:0005829; GO:0008310; GO:0016888; GO:0042542; GO:0046872; GO:0090501 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00901, ECO:0000269|PubMed:10747959, ECO:0000269|PubMed:25114049}. +P30137 THIE_ECOLI Thiamine-phosphate synthase (TP synthase) (TPS) (EC 2.5.1.3) (Thiamine-phosphate pyrophosphorylase) (TMP pyrophosphorylase) (TMP-PPase) thiE b3993 JW3957 thiE 23,015 thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; thiamine-phosphate diphosphorylase activity [GO:0004789]; thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; thiamine-phosphate diphosphorylase activity [GO:0004789] GO:0000287; GO:0004789; GO:0005737; GO:0009228; GO:0009229; GO:0046872 +P24182 ACCC_ECOLI Biotin carboxylase (EC 6.3.4.14) (Acetyl-CoA carboxylase subunit A) (ACC) (EC 6.4.1.2) accC fabG b3256 JW3224 fabG accC 49,321 fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295]; negative regulation of fatty acid biosynthetic process [GO:0045717] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; biotin carboxylase activity [GO:0004075]; metal ion binding [GO:0046872]; fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295]; negative regulation of fatty acid biosynthetic process [GO:0045717] acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; biotin carboxylase activity [GO:0004075]; metal ion binding [GO:0046872] GO:0003989; GO:0004075; GO:0005524; GO:0005737; GO:0005829; GO:0006633; GO:0045717; GO:0046872; GO:2001295 +P00562 AK2H_ECOLI Bifunctional aspartokinase/homoserine dehydrogenase 2 (Aspartokinase II/homoserine dehydrogenase II) (AKII-HDII) [Includes: Aspartokinase (EC 2.7.2.4); Homoserine dehydrogenase (EC 1.1.1.3)] metL metM b3940 JW3911 metM metL 88,888 homoserine biosynthetic process [GO:0009090]; lysine biosynthetic process via diaminopimelate [GO:0009089]; methionine biosynthetic process [GO:0009086]; threonine biosynthetic process [GO:0009088] cytosol [GO:0005829] cytosol [GO:0005829]; aspartate kinase activity [GO:0004072]; ATP binding [GO:0005524]; homoserine dehydrogenase activity [GO:0004412]; NADP binding [GO:0050661]; homoserine biosynthetic process [GO:0009090]; lysine biosynthetic process via diaminopimelate [GO:0009089]; methionine biosynthetic process [GO:0009086]; threonine biosynthetic process [GO:0009088] aspartate kinase activity [GO:0004072]; ATP binding [GO:0005524]; homoserine dehydrogenase activity [GO:0004412]; NADP binding [GO:0050661] GO:0004072; GO:0004412; GO:0005524; GO:0005829; GO:0009086; GO:0009088; GO:0009089; GO:0009090; GO:0050661 +P29012 ALR2_ECOLI Alanine racemase, catabolic (EC 5.1.1.1) dadX alnB dadB b1190 JW1179 alnB dadB dadX 38,845 D-alanine biosynthetic process [GO:0030632]; L-alanine oxidation to pyruvate via D-alanine [GO:0019480] cytosol [GO:0005829] cytosol [GO:0005829]; alanine racemase activity [GO:0008784]; pyridoxal phosphate binding [GO:0030170]; D-alanine biosynthetic process [GO:0030632]; L-alanine oxidation to pyruvate via D-alanine [GO:0019480] alanine racemase activity [GO:0008784]; pyridoxal phosphate binding [GO:0030170] GO:0005829; GO:0008784; GO:0019480; GO:0030170; GO:0030632 +Q46807 ARCL_ECOLI Carbamate kinase-like protein YqeA yqeA b2874 JW2842 yqeA 33,071 arginine deiminase pathway [GO:0019546] cytosol [GO:0005829] cytosol [GO:0005829]; carbamate kinase activity [GO:0008804]; arginine deiminase pathway [GO:0019546] carbamate kinase activity [GO:0008804] GO:0005829; GO:0008804; GO:0019546 +P0A6J3 CYSZ_ECOLI Sulfate transporter CysZ cysZ b2413 JW2406 cysZ 29,305 cysteine biosynthetic process [GO:0019344]; sulfate assimilation [GO:0000103]; sulfate transmembrane transport [GO:1902358] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; high-affinity sulfate:proton symporter activity [GO:0009675]; sulfate transmembrane transporter activity [GO:0015116]; cysteine biosynthetic process [GO:0019344]; sulfate assimilation [GO:0000103]; sulfate transmembrane transport [GO:1902358] high-affinity sulfate:proton symporter activity [GO:0009675]; sulfate transmembrane transporter activity [GO:0015116] GO:0000103; GO:0005886; GO:0005887; GO:0009675; GO:0015116; GO:0019344; GO:1902358 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00468, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00468}. +P0AEA5 CYOE_ECOLI Protoheme IX farnesyltransferase (EC 2.5.1.141) (Heme B farnesyltransferase) (Heme O synthase) cyoE b0428 JW0418 cyoE 32,248 cellular respiration [GO:0045333]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; farnesyltranstransferase activity [GO:0004311]; protoheme IX farnesyltransferase activity [GO:0008495]; cellular respiration [GO:0045333]; heme biosynthetic process [GO:0006783]; heme O biosynthetic process [GO:0048034] farnesyltranstransferase activity [GO:0004311]; protoheme IX farnesyltransferase activity [GO:0008495] GO:0004311; GO:0005886; GO:0006783; GO:0008495; GO:0016021; GO:0045333; GO:0048034 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P00936 CYAA_ECOLI Adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase) cyaA cya b3806 JW3778 cya cyaA 97,586 cAMP biosynthetic process [GO:0006171] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524]; cAMP biosynthetic process [GO:0006171] adenylate cyclase activity [GO:0004016]; ATP binding [GO:0005524] GO:0004016; GO:0005524; GO:0005737; GO:0006171 SUBCELLULAR LOCATION: Cytoplasm. +P77268 DDPD_ECOLI Probable D,D-dipeptide transport ATP-binding protein DdpD ddpD yddP b1484 JW1479 yddP ddpD 36,100 protein transport [GO:0015031] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; protein transport [GO:0015031] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0015031; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P15042 DNLJ_ECOLI DNA ligase (EC 6.5.1.2) (Polydeoxyribonucleotide synthase [NAD(+)]) ligA dnaL lig lop pdeC b2411 JW2403 dnaL lig lop pdeC ligA 73,606 base-excision repair, DNA ligation [GO:0006288]; DNA ligation [GO:0006266]; DNA replication [GO:0006260] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; DNA ligase (NAD+) activity [GO:0003911]; metal ion binding [GO:0046872]; NAD+ binding [GO:0070403]; base-excision repair, DNA ligation [GO:0006288]; DNA ligation [GO:0006266]; DNA replication [GO:0006260] DNA binding [GO:0003677]; DNA ligase (NAD+) activity [GO:0003911]; metal ion binding [GO:0046872]; NAD+ binding [GO:0070403] GO:0003677; GO:0003911; GO:0005829; GO:0006260; GO:0006266; GO:0006288; GO:0046872; GO:0070403 +P0A8J2 DNAT_ECOLI Primosomal protein 1 (Primosomal protein I) dnaT b4362 JW4326 dnaT 19,455 DNA-dependent DNA replication [GO:0006261]; DNA replication, synthesis of RNA primer [GO:0006269]; pre-replicative complex assembly involved in nuclear cell cycle DNA replication [GO:0006267] primosome complex [GO:1990077] primosome complex [GO:1990077]; identical protein binding [GO:0042802]; DNA replication, synthesis of RNA primer [GO:0006269]; DNA-dependent DNA replication [GO:0006261]; pre-replicative complex assembly involved in nuclear cell cycle DNA replication [GO:0006267] identical protein binding [GO:0042802] GO:0006261; GO:0006267; GO:0006269; GO:0042802; GO:1990077 +P09557 DICB_ECOLI Division inhibition protein DicB dicB b1575 JW1566 dicB 6,964 cell cycle [GO:0007049]; cell division [GO:0051301]; negative regulation of cell division [GO:0051782]; regulation of cell division [GO:0051302] cell cycle [GO:0007049]; cell division [GO:0051301]; negative regulation of cell division [GO:0051782]; regulation of cell division [GO:0051302] GO:0007049; GO:0051301; GO:0051302; GO:0051782 +P06965 DICC_ECOLI Repressor protein of division inhibition gene dicB dicC b1569 JW1561 dicC 8,578 cell cycle [GO:0007049]; cell division [GO:0051301] DNA binding [GO:0003677]; cell cycle [GO:0007049]; cell division [GO:0051301] DNA binding [GO:0003677] GO:0003677; GO:0007049; GO:0051301 +P0A6M4 DTD_ECOLI D-aminoacyl-tRNA deacylase (DTD) (EC 3.1.1.96) (D-tyrosyl RNA deacylase) (D-tyrosyl-tRNA(Tyr) deacylase) (Gly-tRNA(Ala) deacylase) (Gly-tRNA(Gly) deacylase) dtd yihZ b3887 JW3858 yihZ dtd 15,950 D-amino acid catabolic process [GO:0019478]; response to heat [GO:0009408]; tRNA metabolic process [GO:0006399] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; aminoacyl-tRNA editing activity [GO:0002161]; D-aminoacyl-tRNA deacylase activity [GO:0051499]; D-tyrosyl-tRNA(Tyr) deacylase activity [GO:0051500]; Gly-tRNA(Ala) hydrolase activity [GO:0106026]; Ser(Gly)-tRNA(Ala) hydrolase activity [GO:0043908]; tRNA binding [GO:0000049]; D-amino acid catabolic process [GO:0019478]; response to heat [GO:0009408]; tRNA metabolic process [GO:0006399] aminoacyl-tRNA editing activity [GO:0002161]; D-aminoacyl-tRNA deacylase activity [GO:0051499]; D-tyrosyl-tRNA(Tyr) deacylase activity [GO:0051500]; Gly-tRNA(Ala) hydrolase activity [GO:0106026]; Ser(Gly)-tRNA(Ala) hydrolase activity [GO:0043908]; tRNA binding [GO:0000049] GO:0000049; GO:0002161; GO:0005737; GO:0006399; GO:0009408; GO:0019478; GO:0043908; GO:0051499; GO:0051500; GO:0106026 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00518, ECO:0000305|PubMed:4292198}. +P76334 DRPB_ECOLI Cell division protein DrpB (Division ring protein B) drpB yedR b1963 JW1946 yedR drpB 11,325 cell cycle [GO:0007049]; cell division [GO:0051301] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cell cycle [GO:0007049]; cell division [GO:0051301] GO:0005886; GO:0007049; GO:0016021; GO:0051301 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00857, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00857, ECO:0000305|PubMed:15919996}. Note=Localizes to the septal ring before constriction, only when cells are grown at low ionic strength. {ECO:0000255|HAMAP-Rule:MF_00857, ECO:0000269|PubMed:32900831}. +P62707 GPMA_ECOLI 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (BPG-dependent PGAM) (PGAM) (Phosphoglyceromutase) (dPGM) (EC 5.4.2.11) gpmA gpm pgm pgmA b0755 JW0738 gpm pgm pgmA gpmA 28,556 canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity [GO:0046538]; ATP binding [GO:0005524]; canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094] 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity [GO:0046538]; ATP binding [GO:0005524] GO:0005524; GO:0005737; GO:0005829; GO:0006094; GO:0046538; GO:0061621 +P63228 GMHBB_ECOLI D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase (EC 3.1.3.82) (D,D-heptose 1,7-bisphosphate phosphatase) (HBP phosphatase) gmhB yaeD b0200 JW0196 yaeD gmhB 21,294 ADP-L-glycero-beta-D-manno-heptose biosynthetic process [GO:0097171]; lipopolysaccharide core region biosynthetic process [GO:0009244] cytosol [GO:0005829] cytosol [GO:0005829]; D,D-heptose 1,7-bisphosphate phosphatase activity [GO:0034200]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270]; ADP-L-glycero-beta-D-manno-heptose biosynthetic process [GO:0097171]; lipopolysaccharide core region biosynthetic process [GO:0009244] D,D-heptose 1,7-bisphosphate phosphatase activity [GO:0034200]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270] GO:0000287; GO:0005829; GO:0008270; GO:0009244; GO:0034200; GO:0097171 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P32056 GMM_ECOLI GDP-mannose mannosyl hydrolase (GDPMH) (EC 3.6.1.-) (Colanic acid biosynthesis protein WcaH) gmm nudD wcaH yefC b2051 JW5335 nudD wcaH yefC gmm 18,273 lipopolysaccharide biosynthetic process [GO:0009103] GDP-glucosidase activity [GO:0047917]; GDP-mannose mannosyl hydrolase activity [GO:0008727]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; lipopolysaccharide biosynthetic process [GO:0009103] GDP-glucosidase activity [GO:0047917]; GDP-mannose mannosyl hydrolase activity [GO:0008727]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145] GO:0000287; GO:0008727; GO:0009103; GO:0030145; GO:0047917 +P77425 ALLC_ECOLI Allantoate amidohydrolase (AAH) (EC 3.5.3.9) (Allantoate deiminase) allC glxB7 ylbB b0516 JW0504 glxB7 ylbB allC 45,694 allantoin assimilation pathway [GO:0009442]; purine nucleobase metabolic process [GO:0006144] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; allantoate deiminase activity [GO:0047652]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; allantoin assimilation pathway [GO:0009442]; purine nucleobase metabolic process [GO:0006144] allantoate deiminase activity [GO:0047652]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270] GO:0005737; GO:0006144; GO:0008270; GO:0009442; GO:0030145; GO:0042803; GO:0047652 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P42907 AGAS_ECOLI Putative D-galactosamine-6-phosphate deaminase AgaS (EC 3.5.99.-) (Gam-6-P deaminase/isomerase) agaS yraB b3136 JW3105 yraB agaS 41,783 carbohydrate derivative metabolic process [GO:1901135]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; carbohydrate derivative binding [GO:0097367]; hydrolase activity [GO:0016787]; isomerase activity [GO:0016853]; carbohydrate derivative metabolic process [GO:1901135]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] carbohydrate derivative binding [GO:0097367]; hydrolase activity [GO:0016787]; isomerase activity [GO:0016853] GO:0005887; GO:0009401; GO:0016787; GO:0016853; GO:0097367; GO:1901135 +P0A6A8 ACP_ECOLI Acyl carrier protein (ACP) (Cytosolic-activating factor) (CAF) (Fatty acid synthase acyl carrier protein) acpP b1094 JW1080 acpP 8,640 fatty acid biosynthetic process [GO:0006633]; lipid A biosynthetic process [GO:0009245]; lipid biosynthetic process [GO:0008610]; response to drug [GO:0042493] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; acyl binding [GO:0000035]; acyl carrier activity [GO:0000036]; lipid binding [GO:0008289]; phosphopantetheine binding [GO:0031177]; fatty acid biosynthetic process [GO:0006633]; lipid A biosynthetic process [GO:0009245]; lipid biosynthetic process [GO:0008610]; response to drug [GO:0042493] acyl binding [GO:0000035]; acyl carrier activity [GO:0000036]; lipid binding [GO:0008289]; phosphopantetheine binding [GO:0031177] GO:0000035; GO:0000036; GO:0005737; GO:0005829; GO:0006633; GO:0008289; GO:0008610; GO:0009245; GO:0031177; GO:0042493 SUBCELLULAR LOCATION: Cytoplasm. +P11667 ARGO_ECOLI Arginine exporter protein ArgO argO yggA b2923 JW2890 yggA argO 23,176 amino acid transport [GO:0006865]; L-arginine transport [GO:1902023] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; arginine transmembrane transporter activity [GO:0015181]; amino acid transport [GO:0006865]; L-arginine transport [GO:1902023] amino acid transmembrane transporter activity [GO:0015171]; arginine transmembrane transporter activity [GO:0015181] GO:0005886; GO:0005887; GO:0006865; GO:0015171; GO:0015181; GO:1902023 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77231 CITG_ECOLI 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase) (EC 2.4.2.52) citG ybdT b0613 JW0605 ybdT citG 31,644 phosphorylation [GO:0016310]; prosthetic group biosynthetic process [GO:0051191] ATP binding [GO:0005524]; triphosphoribosyl-dephospho-CoA synthase activity [GO:0046917]; phosphorylation [GO:0016310]; prosthetic group biosynthetic process [GO:0051191] ATP binding [GO:0005524]; triphosphoribosyl-dephospho-CoA synthase activity [GO:0046917] GO:0005524; GO:0016310; GO:0046917; GO:0051191 +P37690 ENVC_ECOLI Murein hydrolase activator EnvC (Septal ring factor) envC yibP b3613 JW5646 yibP envC 46,595 cell cycle [GO:0007049]; peptidoglycan-based cell wall biogenesis [GO:0009273]; positive regulation of hydrolase activity [GO:0051345]; response to drug [GO:0042493]; response to radiation [GO:0009314]; septum digestion after cytokinesis [GO:0000920] cell division site [GO:0032153]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; plasma membrane [GO:0005886] cell division site [GO:0032153]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; plasma membrane [GO:0005886]; hydrolase activity [GO:0016787]; metalloendopeptidase activity [GO:0004222]; cell cycle [GO:0007049]; peptidoglycan-based cell wall biogenesis [GO:0009273]; positive regulation of hydrolase activity [GO:0051345]; response to drug [GO:0042493]; response to radiation [GO:0009314]; septum digestion after cytokinesis [GO:0000920] hydrolase activity [GO:0016787]; metalloendopeptidase activity [GO:0004222] GO:0000920; GO:0004222; GO:0005886; GO:0007049; GO:0009273; GO:0009314; GO:0016787; GO:0030288; GO:0032153; GO:0042493; GO:0042597; GO:0051345 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:12113939, ECO:0000269|PubMed:15165230, ECO:0000269|PubMed:19525345}. Note=Localizes at the septal ring. +P76298 FLHA_ECOLI Flagellar biosynthesis protein FlhA flhA b1879 JW1868 flhA 74,843 bacterial-type flagellum assembly [GO:0044780]; protein secretion [GO:0009306] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; bacterial-type flagellum assembly [GO:0044780]; protein secretion [GO:0009306] GO:0005886; GO:0009306; GO:0016021; GO:0044780 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P76299 FLHB_ECOLI Flagellar biosynthetic protein FlhB flhB yecQ b1880 JW1869 yecQ flhB 42,238 bacterial-type flagellum assembly [GO:0044780]; protein secretion [GO:0009306] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; bacterial-type flagellum assembly [GO:0044780]; protein secretion [GO:0009306] GO:0005886; GO:0009306; GO:0016021; GO:0044780 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P24183 FDNG_ECOLI Formate dehydrogenase, nitrate-inducible, major subunit (EC 1.17.5.3) (Anaerobic formate dehydrogenase major subunit) (Formate dehydrogenase-N subunit alpha) (FDH-N subunit alpha) fdnG b1474 JW1470 fdnG 112,963 anaerobic respiration [GO:0009061]; formate oxidation [GO:0015944] formate dehydrogenase complex [GO:0009326]; membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288] formate dehydrogenase complex [GO:0009326]; membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; formate dehydrogenase (cytochrome-c-553) activity [GO:0047111]; formate dehydrogenase (NAD+) activity [GO:0008863]; formate dehydrogenase (quinone) activity [GO:0036397]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; selenium binding [GO:0008430]; anaerobic respiration [GO:0009061]; formate oxidation [GO:0015944] 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; formate dehydrogenase (cytochrome-c-553) activity [GO:0047111]; formate dehydrogenase (NAD+) activity [GO:0008863]; formate dehydrogenase (quinone) activity [GO:0036397]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; selenium binding [GO:0008430] GO:0008430; GO:0008863; GO:0009055; GO:0009061; GO:0009326; GO:0015944; GO:0016020; GO:0030151; GO:0030288; GO:0036397; GO:0043546; GO:0047111; GO:0051539 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:11884747}. +Q47129 FEAR_ECOLI Transcriptional activator FeaR feaR maoB maoR ydbM b1384 JW1379 maoB maoR ydbM feaR 34,620 positive regulation of transcription, DNA-templated [GO:0045893] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; positive regulation of transcription, DNA-templated [GO:0045893] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700] GO:0000986; GO:0003700; GO:0045893 +P15030 FECC_ECOLI Fe(3+) dicitrate transport system permease protein FecC (Iron(III) dicitrate transport system permease protein FecC) fecC b4289 JW4249 fecC 34,893 siderophore-dependent iron import into cell [GO:0033214] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; iron chelate transmembrane transporter activity [GO:0015603]; transmembrane transporter activity [GO:0022857]; siderophore-dependent iron import into cell [GO:0033214] iron chelate transmembrane transporter activity [GO:0015603]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0015603; GO:0022857; GO:0033214 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0ACX5 FUMD_ECOLI Fumarase D (EC 4.2.1.2) fumD ydhZ b1675 JW1665 ydhZ fumD 7,907 fumarate hydratase activity [GO:0004333] fumarate hydratase activity [GO:0004333] GO:0004333 +P0AD68 FTSI_ECOLI Peptidoglycan D,D-transpeptidase FtsI (EC 3.4.16.4) (Essential cell division protein FtsI) (Murein transpeptidase) (Penicillin-binding protein 3) (PBP-3) (Peptidoglycan synthase FtsI) ftsI pbpB b0084 JW0082 pbpB ftsI 63,877 cell division [GO:0051301]; cell wall organization [GO:0071555]; division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to drug [GO:0042493] cell division site [GO:0032153]; integral component of plasma membrane [GO:0005887]; intrinsic component of plasma membrane [GO:0031226] cell division site [GO:0032153]; integral component of plasma membrane [GO:0005887]; intrinsic component of plasma membrane [GO:0031226]; penicillin binding [GO:0008658]; peptidoglycan glycosyltransferase activity [GO:0008955]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002]; cell division [GO:0051301]; cell wall organization [GO:0071555]; division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to drug [GO:0042493] penicillin binding [GO:0008658]; peptidoglycan glycosyltransferase activity [GO:0008955]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002] GO:0000917; GO:0005887; GO:0008360; GO:0008658; GO:0008955; GO:0009002; GO:0009252; GO:0031226; GO:0032153; GO:0042493; GO:0043093; GO:0051301; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02080, ECO:0000269|PubMed:2677607, ECO:0000269|PubMed:9614966}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02080, ECO:0000269|PubMed:2677607, ECO:0000269|PubMed:9614966}; Periplasmic side {ECO:0000269|PubMed:2677607, ECO:0000269|PubMed:9614966}. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space (PubMed:2677607, PubMed:9614966). Localizes to the division septum during the later stages of cell growth and throughout septation (PubMed:9379897, PubMed:9603865, PubMed:9882665, PubMed:15601716). Localization is dependent on FtsZ, FtsA, FtsK, FtsQ, FtsL and FtsW, but not on FtsN (PubMed:9603865, PubMed:9882665, PubMed:11703663, PubMed:11807049). {ECO:0000269|PubMed:11703663, ECO:0000269|PubMed:11807049, ECO:0000269|PubMed:15601716, ECO:0000269|PubMed:2677607, ECO:0000269|PubMed:9379897, ECO:0000269|PubMed:9603865, ECO:0000269|PubMed:9614966, ECO:0000269|PubMed:9882665}. +P39835 GNTT_ECOLI High-affinity gluconate transporter (Gluconate permease) (Gnt-I system) gntT gntM usgA yhgC b3415 JW5690 gntM usgA yhgC gntT 45,967 carbohydrate transport [GO:0008643]; D-gluconate catabolic process [GO:0046177]; gluconate transmembrane transport [GO:0035429] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; gluconate transmembrane transporter activity [GO:0015128]; carbohydrate transport [GO:0008643]; D-gluconate catabolic process [GO:0046177]; gluconate transmembrane transport [GO:0035429] gluconate transmembrane transporter activity [GO:0015128] GO:0005886; GO:0005887; GO:0008643; GO:0015128; GO:0016020; GO:0035429; GO:0046177 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0ACB7 HEMY_ECOLI Protein HemY hemY b3802 JW3774 hemY 45,245 heme metabolic process [GO:0042168]; porphyrin-containing compound biosynthetic process [GO:0006779] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; heme metabolic process [GO:0042168]; porphyrin-containing compound biosynthetic process [GO:0006779] GO:0005886; GO:0006779; GO:0016021; GO:0042168 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76340 HPRR_ECOLI Transcriptional regulatory protein HprR (Hydrogen peroxide response regulator) hprR yedW b1969 JW5322 yedW hprR 25,018 negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893] DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000976; GO:0001216; GO:0003677; GO:0003700; GO:0005829; GO:0032993; GO:0045892; GO:0045893 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P28630 HOLA_ECOLI DNA polymerase III subunit delta (EC 2.7.7.7) holA b0640 JW0635 holA 38,704 DNA-dependent DNA replication [GO:0006261] DNA polymerase III complex [GO:0009360] DNA polymerase III complex [GO:0009360]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; DNA-dependent DNA replication [GO:0006261] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887] GO:0003677; GO:0003887; GO:0006261; GO:0009360 +P39377 IADA_ECOLI Isoaspartyl dipeptidase (EC 3.4.19.-) iadA yjiF b4328 JW4291 yjiF iadA 41,084 cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; beta-aspartyl-peptidase activity [GO:0008798]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]; identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] beta-aspartyl-peptidase activity [GO:0008798]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]; identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] GO:0005737; GO:0005829; GO:0008237; GO:0008270; GO:0008798; GO:0016810; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7876157}. +P0CK95 ACFD_ECOLI Putative lipoprotein AcfD homolog yghJ b4466 JW5925 ECK2968 yghJ 167,246 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P0AE26 ARAH_ECOLI L-arabinose transport system permease protein AraH araH b4460 JW1887 araH 34,211 arabinose transmembrane transport [GO:0015751] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; L-arabinose transmembrane transporter activity [GO:0015147]; arabinose transmembrane transport [GO:0015751] L-arabinose transmembrane transporter activity [GO:0015147] GO:0005886; GO:0015147; GO:0015751; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P23908 ARGE_ECOLI Acetylornithine deacetylase (AO) (Acetylornithinase) (EC 3.5.1.16) (N-acetylornithinase) (NAO) argE b3957 JW3929 argE 42,347 arginine biosynthetic process [GO:0006526] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; acetylornithine deacetylase activity [GO:0008777]; cobalt ion binding [GO:0050897]; zinc ion binding [GO:0008270]; arginine biosynthetic process [GO:0006526] acetylornithine deacetylase activity [GO:0008777]; cobalt ion binding [GO:0050897]; zinc ion binding [GO:0008270] GO:0005737; GO:0006526; GO:0008270; GO:0008777; GO:0050897 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AE16 AMPG_ECOLI Anhydromuropeptide permease (AmpG permease) (Muropeptide:H(+) symporter) ampG b0433 JW0423 ampG 53,245 cell wall organization [GO:0071555]; peptidoglycan transport [GO:0015835] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; solute:proton symporter activity [GO:0015295]; cell wall organization [GO:0071555]; peptidoglycan transport [GO:0015835] solute:proton symporter activity [GO:0015295] GO:0005886; GO:0015295; GO:0015835; GO:0016021; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15728916, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15728916}. +P0ACI6 ASNC_ECOLI Regulatory protein AsnC asnC b3743 JW3721 asnC 16,888 negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; response to amino acid [GO:0043200] amino acid binding [GO:0016597]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; response to amino acid [GO:0043200] amino acid binding [GO:0016597]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0016597; GO:0043200; GO:0043565; GO:0045892; GO:0045893 +P12999 BIOC_ECOLI Malonyl-[acyl-carrier protein] O-methyltransferase (Malonyl-ACP O-methyltransferase) (EC 2.1.1.197) (Biotin synthesis protein BioC) bioC b0777 JW0760 bioC 28,276 biotin biosynthetic process [GO:0009102]; methylation [GO:0032259] carboxyl-O-methyltransferase activity [GO:0010340]; malonyl-CoA methyltransferase activity [GO:0102130]; biotin biosynthetic process [GO:0009102]; methylation [GO:0032259] carboxyl-O-methyltransferase activity [GO:0010340]; malonyl-CoA methyltransferase activity [GO:0102130] GO:0009102; GO:0010340; GO:0032259; GO:0102130 +P19925 ENTD_ECOLI Enterobactin synthase component D (4'-phosphopantetheinyl transferase EntD) (EC 2.7.8.-) (Enterochelin synthase D) entD b0583 JW5085 entD 23,259 enterobactin biosynthetic process [GO:0009239]; siderophore metabolic process [GO:0009237] enterobactin synthetase complex [GO:0009366]; intrinsic component of plasma membrane [GO:0031226] enterobactin synthetase complex [GO:0009366]; intrinsic component of plasma membrane [GO:0031226]; holo-[acyl-carrier-protein] synthase activity [GO:0008897]; magnesium ion binding [GO:0000287]; enterobactin biosynthetic process [GO:0009239]; siderophore metabolic process [GO:0009237] holo-[acyl-carrier-protein] synthase activity [GO:0008897]; magnesium ion binding [GO:0000287] GO:0000287; GO:0008897; GO:0009237; GO:0009239; GO:0009366; GO:0031226 SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:2526281}. +P22586 FLIO_ECOLI Flagellar protein FliO fliO flaP flbD b1947 JW5316 flaP flbD fliO 12,670 archaeal or bacterial-type flagellum-dependent cell motility [GO:0097588]; bacterial-type flagellum organization [GO:0044781]; chemotaxis [GO:0006935] bacterial-type flagellum basal body [GO:0009425]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] bacterial-type flagellum basal body [GO:0009425]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; archaeal or bacterial-type flagellum-dependent cell motility [GO:0097588]; bacterial-type flagellum organization [GO:0044781]; chemotaxis [GO:0006935] GO:0005886; GO:0006935; GO:0009425; GO:0016021; GO:0044781; GO:0097588 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Bacterial flagellum basal body {ECO:0000250}. +P0A8S9 FLHD_ECOLI Flagellar transcriptional regulator FlhD flhD flbB b1892 JW1881 flbB flhD 13,316 bacterial-type flagellum assembly [GO:0044780]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of bacterial-type flagellum assembly [GO:1902208]; transcription, DNA-templated [GO:0006351] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; bacterial-type flagellum assembly [GO:0044780]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of bacterial-type flagellum assembly [GO:1902208]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677] GO:0003677; GO:0005737; GO:0006351; GO:0044780; GO:0045893; GO:1902208 SUBCELLULAR LOCATION: Cytoplasm. +P15070 FLIN_ECOLI Flagellar motor switch protein FliN fliN flaN motD b1946 JW1930 flaN motD fliN 14,855 bacterial-type flagellum-dependent cell motility [GO:0071973]; chemotaxis [GO:0006935] bacterial-type flagellum basal body [GO:0009425]; plasma membrane [GO:0005886] bacterial-type flagellum basal body [GO:0009425]; plasma membrane [GO:0005886]; motor activity [GO:0003774]; bacterial-type flagellum-dependent cell motility [GO:0071973]; chemotaxis [GO:0006935] motor activity [GO:0003774] GO:0003774; GO:0005886; GO:0006935; GO:0009425; GO:0071973 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Bacterial flagellum basal body. +P0AC07 FLIQ_ECOLI Flagellar biosynthetic protein FliQ fliQ flaQ b1949 JW1933 flaQ fliQ 9,632 bacterial-type flagellum assembly [GO:0044780]; protein secretion [GO:0009306] bacterial-type flagellum basal body [GO:0009425]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] bacterial-type flagellum basal body [GO:0009425]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; bacterial-type flagellum assembly [GO:0044780]; protein secretion [GO:0009306] GO:0005886; GO:0009306; GO:0009425; GO:0016021; GO:0044780 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Bacterial flagellum basal body {ECO:0000250}. +P20605 FIC_ECOLI Probable protein adenylyltransferase Fic (EC 2.7.7.n1) (Cell filamentation protein Fic) fic b3361 JW3324 fic 22,960 regulation of cell division [GO:0051302] ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; regulation of cell division [GO:0051302] ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779] GO:0005524; GO:0016779; GO:0051302 +P08189 FIMF_ECOLI Protein FimF fimF b4318 JW4281 fimF 18,715 cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium. +P08191 FIMH_ECOLI Type 1 fimbrin D-mannose specific adhesin (Protein FimH) fimH b4320 JW4283 fimH 31,473 cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] host cell membrane [GO:0033644]; pilus [GO:0009289] host cell membrane [GO:0033644]; pilus [GO:0009289]; mannose binding [GO:0005537]; cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] mannose binding [GO:0005537] GO:0005537; GO:0007155; GO:0009289; GO:0033644; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000269|PubMed:1971261}. +P11551 FUCP_ECOLI L-fucose-proton symporter (6-deoxy-L-galactose permease) (L-fucose permease) (L-fucose-H(+) symport protein) fucP b2801 JW2772 fucP 47,545 arabinose transmembrane transport [GO:0015751]; fucose metabolic process [GO:0006004]; fucose transmembrane transport [GO:0015756]; galactose transmembrane transport [GO:0015757] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; arabinose:proton symporter activity [GO:0015518]; fucose:proton symporter activity [GO:0015535]; galactose:proton symporter activity [GO:0015517]; arabinose transmembrane transport [GO:0015751]; fucose metabolic process [GO:0006004]; fucose transmembrane transport [GO:0015756]; galactose transmembrane transport [GO:0015757] arabinose:proton symporter activity [GO:0015518]; fucose:proton symporter activity [GO:0015535]; galactose:proton symporter activity [GO:0015517] GO:0005886; GO:0006004; GO:0015517; GO:0015518; GO:0015535; GO:0015751; GO:0015756; GO:0015757; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:20877283}; Multi-pass membrane protein {ECO:0000269|PubMed:20877283}. +P26649 GLGS_ECOLI Surface composition regulator glgS scoR b3049 JW3021 scoR glgS 7,892 negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201]; negative regulation of single-species biofilm formation on inanimate substrate [GO:1900232]; positive regulation of cellular carbohydrate metabolic process [GO:0010676] negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201]; negative regulation of single-species biofilm formation on inanimate substrate [GO:1900232]; positive regulation of cellular carbohydrate metabolic process [GO:0010676] GO:0010676; GO:1900232; GO:1902201 +P75885 GFCA_ECOLI Threonine-rich inner membrane protein GfcA (Group 4 capsule protein A homolog) gfcA ymcD b0987 JW5133 ymcD gfcA 9,508 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein. Note=When the protein is overexpressed. +P0A932 GFCE_ECOLI Putative polysaccharide export protein GfcE (Group 4 capsule protein E homolog) gfcE yccZ b0983 JW0966 yccZ gfcE 41,741 cell outer membrane [GO:0009279]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; pore complex [GO:0046930]; polysaccharide transmembrane transporter activity [GO:0015159]; porin activity [GO:0015288] polysaccharide transmembrane transporter activity [GO:0015159]; porin activity [GO:0015288] GO:0009279; GO:0015159; GO:0015288; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. +P28721 GLTF_ECOLI Protein GltF gltF b3214 JW3181 gltF 26,352 integral component of membrane [GO:0016021]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] GO:0005886; GO:0016021; GO:0030288 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +Q46851 GPR_ECOLI L-glyceraldehyde 3-phosphate reductase (GAP reductase) (EC 1.1.1.-) gpr mgrA yghZ b3001 JW2970 mgrA yghZ gpr 38,832 cellular response to DNA damage stimulus [GO:0006974]; methylglyoxal catabolic process [GO:0051596] D-threo-aldose 1-dehydrogenase activity [GO:0047834]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; cellular response to DNA damage stimulus [GO:0006974]; methylglyoxal catabolic process [GO:0051596] D-threo-aldose 1-dehydrogenase activity [GO:0047834]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] GO:0006974; GO:0016616; GO:0047834; GO:0051596 +P45760 GSPI_ECOLI Putative type II secretion system protein I (T2SS minor pseudopilin I) (Putative general secretion pathway protein I) gspI yheH b3330 JW5706 yheH gspI 13,901 protein secretion by the type II secretion system [GO:0015628] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627]; protein secretion by the type II secretion system [GO:0015628] GO:0005886; GO:0015627; GO:0015628; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:Q00516}; Single-pass membrane protein {ECO:0000255}. +P15038 HELD_ECOLI DNA helicase IV (EC 3.6.4.12) (75 kDa helicase) helD b0962 JW0945 helD 77,976 DNA recombination [GO:0006310]; recombinational repair [GO:0000725] cytosol [GO:0005829]; DNA helicase complex [GO:0033202] cytosol [GO:0005829]; DNA helicase complex [GO:0033202]; 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA recombination [GO:0006310]; recombinational repair [GO:0000725] 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; DNA binding [GO:0003677] GO:0000725; GO:0003677; GO:0005524; GO:0005829; GO:0006310; GO:0033202; GO:0043138 +P0AA82 CODB_ECOLI Cytosine permease codB b0336 JW0327 codB 43,650 cytosine metabolic process [GO:0019858]; cytosine transport [GO:0015856]; proton transmembrane transport [GO:1902600] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cytosine transmembrane transporter activity [GO:0015209]; cytosine metabolic process [GO:0019858]; cytosine transport [GO:0015856]; proton transmembrane transport [GO:1902600] cytosine transmembrane transporter activity [GO:0015209] GO:0005886; GO:0015209; GO:0015856; GO:0016020; GO:0016021; GO:0019858; GO:1902600 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A9B6 E4PD_ECOLI D-erythrose-4-phosphate dehydrogenase (E4PDH) (EC 1.2.1.72) epd gapB b2927 JW2894 gapB epd 37,299 glucose metabolic process [GO:0006006]; pyridoxal phosphate biosynthetic process [GO:0042823]; pyridoxine biosynthetic process [GO:0008615] cytosol [GO:0005829] cytosol [GO:0005829]; erythrose-4-phosphate dehydrogenase activity [GO:0048001]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287]; glucose metabolic process [GO:0006006]; pyridoxal phosphate biosynthetic process [GO:0042823]; pyridoxine biosynthetic process [GO:0008615] erythrose-4-phosphate dehydrogenase activity [GO:0048001]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287] GO:0004365; GO:0005829; GO:0006006; GO:0008615; GO:0042823; GO:0048001; GO:0051287 SUBCELLULAR LOCATION: Cytoplasm. +P77188 ECPB_ECOLI Probable fimbrial chaperone EcpB ecpB matC yagY b0292 JW0286 matC yagY ecpB 24,517 +P0DSF9 EVGL_ECOLI Protein EvgL evgL b4781 evgL 1,029 +P0AEJ8 EUTN_ECOLI Bacterial microcompartment vertex protein EutN (Ethanolamine catabolic microcompartment shell protein EutN) (Ethanolamine utilization protein EutN) eutN cchB yffY b2456 JW2440 cchB yffY eutN 9,956 cellular response to DNA damage stimulus [GO:0006974]; ethanolamine catabolic process [GO:0046336]; protein hexamerization [GO:0034214] identical protein binding [GO:0042802]; cellular response to DNA damage stimulus [GO:0006974]; ethanolamine catabolic process [GO:0046336]; protein hexamerization [GO:0034214] identical protein binding [GO:0042802] GO:0006974; GO:0034214; GO:0042802; GO:0046336 SUBCELLULAR LOCATION: Bacterial microcompartment {ECO:0000305|PubMed:17588214, ECO:0000305|PubMed:18292340}. +P0A9L3 FKBB_ECOLI FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase (FKBP22) (PPIase) (EC 5.2.1.8) (Rotamase) fklB ytfC b4207 JW5746 ytfC fklB 22,216 protein folding [GO:0006457] cytosol [GO:0005829]; periplasmic space [GO:0042597] cytosol [GO:0005829]; periplasmic space [GO:0042597]; FK506 binding [GO:0005528]; identical protein binding [GO:0042802]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding [GO:0006457] FK506 binding [GO:0005528]; identical protein binding [GO:0042802]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755] GO:0003755; GO:0005528; GO:0005829; GO:0006457; GO:0042597; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic. +P77307 FETB_ECOLI Probable iron export permease protein FetB fetB ybbM b0491 JW5066 ybbM fetB 28,165 cellular iron ion homeostasis [GO:0006879]; ion transport [GO:0006811] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cellular iron ion homeostasis [GO:0006879]; ion transport [GO:0006811] GO:0005886; GO:0005887; GO:0006811; GO:0006879 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:24038693}; Multi-pass membrane protein {ECO:0000269|PubMed:24038693}. +P0AB87 FUCA_ECOLI L-fuculose phosphate aldolase (EC 4.1.2.17) (D-ribulose-phosphate aldolase) (L-fuculose-1-phosphate aldolase) fucA fucC prd b2800 JW2771 fucC prd fucA 23,775 D-arabinose catabolic process [GO:0019571]; L-fucose catabolic process [GO:0042355]; pentose catabolic process [GO:0019323] cytosol [GO:0005829] cytosol [GO:0005829]; aldehyde-lyase activity [GO:0016832]; L-fuculose-phosphate aldolase activity [GO:0008738]; zinc ion binding [GO:0008270]; D-arabinose catabolic process [GO:0019571]; L-fucose catabolic process [GO:0042355]; pentose catabolic process [GO:0019323] aldehyde-lyase activity [GO:0016832]; L-fuculose-phosphate aldolase activity [GO:0008738]; zinc ion binding [GO:0008270] GO:0005829; GO:0008270; GO:0008738; GO:0016832; GO:0019323; GO:0019571; GO:0042355 +P0ACL5 GLCC_ECOLI Glc operon transcriptional activator (Glc regulatory protein) (HTH-type transcriptional regulator GlcC) glcC yghN b2980 JW2947 yghN glcC 28,826 regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006355 +P0A9S5 GLDA_ECOLI Glycerol dehydrogenase (GDH) (GLDH) (EC 1.1.1.6) gldA b3945 JW5556 gldA 38,712 anaerobic glycerol catabolic process [GO:0019588]; methylglyoxal catabolic process [GO:0051596]; protein homotetramerization [GO:0051289] cytosol [GO:0005829] cytosol [GO:0005829]; (R)-aminopropanol dehydrogenase activity [GO:0019147]; glycerol dehydrogenase [NAD+] activity [GO:0008888]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; anaerobic glycerol catabolic process [GO:0019588]; methylglyoxal catabolic process [GO:0051596]; protein homotetramerization [GO:0051289] (R)-aminopropanol dehydrogenase activity [GO:0019147]; glycerol dehydrogenase [NAD+] activity [GO:0008888]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] GO:0005829; GO:0008270; GO:0008888; GO:0019147; GO:0019588; GO:0042802; GO:0051289; GO:0051596 +P0A6T9 GCSH_ECOLI Glycine cleavage system H protein gcvH b2904 JW2872 gcvH 13,811 glycine decarboxylation via glycine cleavage system [GO:0019464]; protein lipoylation [GO:0009249] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glycine cleavage complex [GO:0005960] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glycine cleavage complex [GO:0005960]; lipoic acid binding [GO:0031405]; glycine decarboxylation via glycine cleavage system [GO:0019464]; protein lipoylation [GO:0009249] lipoic acid binding [GO:0031405] GO:0005737; GO:0005829; GO:0005960; GO:0009249; GO:0019464; GO:0031405 +P09832 GLTD_ECOLI Glutamate synthase [NADPH] small chain (EC 1.4.1.13) (Glutamate synthase subunit beta) (GLTS beta chain) (NADPH-GOGAT) gltD aspB b3213 JW3180 aspB gltD 52,015 glutamate biosynthetic process [GO:0006537]; L-glutamate biosynthetic process [GO:0097054] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; glutamate synthase (NADPH) activity [GO:0004355]; metal ion binding [GO:0046872]; glutamate biosynthetic process [GO:0006537]; L-glutamate biosynthetic process [GO:0097054] 4 iron, 4 sulfur cluster binding [GO:0051539]; glutamate synthase (NADPH) activity [GO:0004355]; metal ion binding [GO:0046872] GO:0004355; GO:0005829; GO:0006537; GO:0046872; GO:0051539; GO:0097054 +P46846 GNTX_ECOLI DNA utilization protein YhgH (Protein GntX) gntX yhgH b3413 JW5691 yhgH gntX 25,726 carbon utilization [GO:0015976]; DNA catabolic process [GO:0006308]; nucleoside metabolic process [GO:0009116] carbon utilization [GO:0015976]; DNA catabolic process [GO:0006308]; nucleoside metabolic process [GO:0009116] GO:0006308; GO:0009116; GO:0015976 +P0ACC7 GLMU_ECOLI Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)] glmU yieA b3730 JW3708 yieA glmU 49,190 cell morphogenesis [GO:0000902]; cell wall organization [GO:0071555]; lipid A biosynthetic process [GO:0009245]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] cytosol [GO:0005829] cytosol [GO:0005829]; glucosamine-1-phosphate N-acetyltransferase activity [GO:0019134]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; UDP-N-acetylglucosamine diphosphorylase activity [GO:0003977]; cell morphogenesis [GO:0000902]; cell wall organization [GO:0071555]; lipid A biosynthetic process [GO:0009245]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] glucosamine-1-phosphate N-acetyltransferase activity [GO:0019134]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; UDP-N-acetylglucosamine diphosphorylase activity [GO:0003977] GO:0000287; GO:0000902; GO:0003977; GO:0005829; GO:0006048; GO:0008360; GO:0009245; GO:0009252; GO:0019134; GO:0042802; GO:0071555 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:10428949}. +P36553 HEM6_ECOLI Oxygen-dependent coproporphyrinogen-III oxidase (CPO) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3) hemF b2436 JW2429 hemF 34,323 heme biosynthetic process [GO:0006783]; protoporphyrinogen IX biosynthetic process [GO:0006782] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; coproporphyrinogen oxidase activity [GO:0004109]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]; tetrapyrrole binding [GO:0046906]; heme biosynthetic process [GO:0006783]; protoporphyrinogen IX biosynthetic process [GO:0006782] coproporphyrinogen oxidase activity [GO:0004109]; manganese ion binding [GO:0030145]; protein homodimerization activity [GO:0042803]; tetrapyrrole binding [GO:0046906] GO:0004109; GO:0005737; GO:0006782; GO:0006783; GO:0030145; GO:0042803; GO:0046906 SUBCELLULAR LOCATION: Cytoplasm. +P0A6Y5 HSLO_ECOLI 33 kDa chaperonin (Heat shock protein 33) (HSP33) hslO yrfI b3401 JW5692 yrfI hslO 32,534 maintenance of unfolded protein [GO:0036506]; protein refolding [GO:0042026]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]; maintenance of unfolded protein [GO:0036506]; protein refolding [GO:0042026]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979] identical protein binding [GO:0042802]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270] GO:0005737; GO:0005829; GO:0006979; GO:0008270; GO:0009408; GO:0036506; GO:0042026; GO:0042802; GO:0044183; GO:0051082 SUBCELLULAR LOCATION: Cytoplasm. +P36646 HOFC_ECOLI Protein transport protein HofC homolog hofC hopC yacD b0106 JW0102 hopC yacD hofC 44,450 protein secretion by the type II secretion system [GO:0015628] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein secretion by the type II secretion system [GO:0015628] GO:0005886; GO:0015628; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P28632 HOLD_ECOLI DNA polymerase III subunit psi (EC 2.7.7.7) holD b4372 JW4334 holD 15,174 DNA replication [GO:0006260]; response to radiation [GO:0009314] 3'-5' exonuclease activity [GO:0008408]; DNA-directed DNA polymerase activity [GO:0003887]; DNA replication [GO:0006260]; response to radiation [GO:0009314] 3'-5' exonuclease activity [GO:0008408]; DNA-directed DNA polymerase activity [GO:0003887] GO:0003887; GO:0006260; GO:0008408; GO:0009314 +P45578 LUXS_ECOLI S-ribosylhomocysteine lyase (EC 4.4.1.21) (AI-2 synthesis protein) (Autoinducer-2 production protein LuxS) luxS ygaG b2687 JW2662 ygaG luxS 19,416 L-methionine salvage from S-adenosylmethionine [GO:0019284]; quorum sensing [GO:0009372] cytosol [GO:0005829] cytosol [GO:0005829]; iron ion binding [GO:0005506]; S-ribosylhomocysteine lyase activity [GO:0043768]; L-methionine salvage from S-adenosylmethionine [GO:0019284]; quorum sensing [GO:0009372] iron ion binding [GO:0005506]; S-ribosylhomocysteine lyase activity [GO:0043768] GO:0005506; GO:0005829; GO:0009372; GO:0019284; GO:0043768 +P0CF07 INSA1_ECOLI Insertion element IS1 1 protein InsA (IS1a) insA1 b0022 JW0021 insA1 9,868 transposition, DNA-mediated [GO:0006313] transposition, DNA-mediated [GO:0006313] GO:0006313 +P0CE54 INSH7_ECOLI Transposase InsH for insertion sequence element IS5I insH7 b2030 JW2014 insH7 37,851 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CF69 INSE4_ECOLI Transposase InsE for insertion sequence IS3D insE4 b1027 JW5144 insE4 11,543 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CE49 INSH1_ECOLI Transposase InsH for insertion sequence element IS5A insH1 b0259 JW0250 insH1 37,851 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CF92 INSL2_ECOLI Putative transposase InsL for insertion sequence element IS186B insL2 b0582 JW0572 insL2 40,909 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CF93 INSL3_ECOLI Putative transposase InsL for insertion sequence element IS186C insL3 b2394 JW5390 insL3 40,909 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P76268 KDGR_ECOLI Transcriptional regulator KdgR kdgR yebP b1827 JW1816 yebP kdgR 30,029 negative regulation of transcription, DNA-templated [GO:0045892] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0005829; GO:0045892 +P77674 ABDH_ECOLI Gamma-aminobutyraldehyde dehydrogenase (ABALDH) (EC 1.2.1.19) (1-pyrroline dehydrogenase) (4-aminobutanal dehydrogenase) (5-aminopentanal dehydrogenase) (EC 1.2.1.-) patD prr ydcW b1444 JW1439 prr ydcW patD 50,830 L-lysine catabolic process [GO:0019477]; protein homotetramerization [GO:0051289]; putrescine catabolic process [GO:0009447] cytosol [GO:0005829] cytosol [GO:0005829]; 1-pyrroline dehydrogenase activity [GO:0033737]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aminobutyraldehyde dehydrogenase activity [GO:0019145]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; L-lysine catabolic process [GO:0019477]; protein homotetramerization [GO:0051289]; putrescine catabolic process [GO:0009447] 1-pyrroline dehydrogenase activity [GO:0033737]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aminobutyraldehyde dehydrogenase activity [GO:0019145]; identical protein binding [GO:0042802]; NAD binding [GO:0051287] GO:0004029; GO:0005829; GO:0009447; GO:0019145; GO:0019477; GO:0033737; GO:0042802; GO:0051287; GO:0051289 +P26365 AMIB_ECOLI N-acetylmuramoyl-L-alanine amidase AmiB (EC 3.5.1.28) amiB yjeD b4169 JW4127 yjeD amiB 47,985 cell wall organization [GO:0071555]; FtsZ-dependent cytokinesis [GO:0043093]; peptidoglycan catabolic process [GO:0009253] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; cell wall organization [GO:0071555]; FtsZ-dependent cytokinesis [GO:0043093]; peptidoglycan catabolic process [GO:0009253] N-acetylmuramoyl-L-alanine amidase activity [GO:0008745] GO:0008745; GO:0009253; GO:0030288; GO:0043093; GO:0071555 SUBCELLULAR LOCATION: Periplasm {ECO:0000250}. +P0ACU0 CECR_ECOLI HTH-type transcriptional dual regulator CecR (Regulator of cefoperazone and chloramphenicol sensitivity) cecR ybiH b0796 JW0780 ybiH cecR 25,017 negative regulation of DNA-templated transcription, initiation [GO:2000143]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of DNA-templated transcription, initiation [GO:2000143]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0005737; GO:0006351; GO:0006355; GO:0042802; GO:2000143; GO:2000144 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P69330 CITD_ECOLI Citrate lyase acyl carrier protein (Citrate lyase gamma chain) citD ybdX b0617 JW0609 ybdX citD 10,689 cytoplasm [GO:0005737] cytoplasm [GO:0005737]; prosthetic group binding [GO:0051192] prosthetic group binding [GO:0051192] GO:0005737; GO:0051192 SUBCELLULAR LOCATION: Cytoplasm. +P75974 COHE_ECOLI Prophage repressor CohE (Putative lambdoid prophage e14 repressor protein C2) cohE ymfK b1145 JW1131 ymfK cohE 25,095 DNA binding [GO:0003677] DNA binding [GO:0003677] GO:0003677 +P0ACZ4 EVGA_ECOLI DNA-binding transcriptional activator EvgA evgA b2369 JW2366 evgA 22,690 phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; sequence-specific DNA binding [GO:0043565]; phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] sequence-specific DNA binding [GO:0043565] GO:0000160; GO:0005829; GO:0006355; GO:0043565 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P15286 FLK_ECOLI Flagellar regulator flk (Fluke) flk div b2321 JW2318 div flk 36,668 regulation of gene expression [GO:0010468] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; regulation of gene expression [GO:0010468] GO:0005886; GO:0010468; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P0ABX2 FLGC_ECOLI Flagellar basal-body rod protein FlgC (Putative proximal rod protein) flgC fla FIII flaW b1074 JW1061 fla FIII flaW flgC 13,968 bacterial-type flagellum-dependent swarming motility [GO:0071978] bacterial-type flagellum basal body, rod [GO:0030694]; bacterial-type flagellum hook [GO:0009424] bacterial-type flagellum basal body, rod [GO:0030694]; bacterial-type flagellum hook [GO:0009424]; bacterial-type flagellum-dependent swarming motility [GO:0071978] GO:0009424; GO:0030694; GO:0071978 SUBCELLULAR LOCATION: Bacterial flagellum basal body. +P75937 FLGE_ECOLI Flagellar hook protein FlgE flgE fla FV flaK b1076 JW1063 fla FV flaK flgE 42,045 bacterial-type flagellum-dependent swarming motility [GO:0071978] bacterial-type flagellum basal body [GO:0009425]; bacterial-type flagellum hook [GO:0009424]; cytosol [GO:0005829] bacterial-type flagellum basal body [GO:0009425]; bacterial-type flagellum hook [GO:0009424]; cytosol [GO:0005829]; bacterial-type flagellum-dependent swarming motility [GO:0071978] GO:0005829; GO:0009424; GO:0009425; GO:0071978 SUBCELLULAR LOCATION: Bacterial flagellum basal body {ECO:0000250}. +P13024 FDHE_ECOLI Protein FdhE fdhE b3891 JW3862 fdhE 34,747 protein maturation [GO:0051604] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ferric iron binding [GO:0008199]; protein maturation [GO:0051604] ferric iron binding [GO:0008199] GO:0005737; GO:0005829; GO:0008199; GO:0051604 SUBCELLULAR LOCATION: Cytoplasm. +P04128 FIMA1_ECOLI Type-1 fimbrial protein, A chain (Type-1A pilin) fimA pilA b4314 JW4277 pilA fimA 18,111 cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; identical protein binding [GO:0042802]; cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] identical protein binding [GO:0042802] GO:0007155; GO:0009289; GO:0042802; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium. +P08190 FIMG_ECOLI Protein FimG fimG b4319 JW4282 fimG 17,317 cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium. +P0A9A2 FTNB_ECOLI Bacterial non-heme ferritin-like protein ftnB yecI b1902 JW1890 yecI ftnB 18,894 intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]; intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826] ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322] GO:0004322; GO:0005737; GO:0005829; GO:0006826; GO:0006880; GO:0008198; GO:0008199 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A9R7 FTSE_ECOLI Cell division ATP-binding protein FtsE ftsE b3463 JW3428 ftsE 24,439 cell cycle [GO:0007049]; cell division [GO:0051301]; response to antibiotic [GO:0046677]; transmembrane transport [GO:0055085] cell division site [GO:0032153]; cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886] cell division site [GO:0032153]; cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of membrane [GO:0019898]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; transmembrane transporter activity [GO:0022857]; cell cycle [GO:0007049]; cell division [GO:0051301]; response to antibiotic [GO:0046677]; transmembrane transport [GO:0055085] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; transmembrane transporter activity [GO:0022857] GO:0005524; GO:0005737; GO:0005886; GO:0007049; GO:0019898; GO:0022857; GO:0031234; GO:0032153; GO:0042626; GO:0046677; GO:0051301; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:10048040, ECO:0000269|PubMed:3323846}; Peripheral membrane protein {ECO:0000269|PubMed:10048040}; Cytoplasmic side {ECO:0000305}. Note=Associated with the membrane through an interaction with FtsX (PubMed:10048040). Localizes to the septal ring at the later stages of cell growth and remains there until division is complete (PubMed:14729705). This localization is dependent on localization of FtsZ, FtsA and ZipA, but not on the downstream division proteins FtsK, FtsQ or FtsI (PubMed:14729705). {ECO:0000269|PubMed:10048040, ECO:0000269|PubMed:14729705}. +P0AF61 GHOS_ECOLI Endoribonuclease antitoxin GhoS (EC 3.1.-.-) (Antitoxin GhoS) ghoS arT yjdK b4128 JW4089 arT yjdK ghoS 11,468 endoribonuclease activity [GO:0004521] endoribonuclease activity [GO:0004521] GO:0004521 +P75913 GHRA_ECOLI Glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) (EC 1.1.1.81) (2-ketoacid reductase) ghrA ycdW b1033 JW5146 ycdW ghrA 35,343 cytosol [GO:0005829]; plasma membrane [GO:0005886] cytosol [GO:0005829]; plasma membrane [GO:0005886]; glycerate dehydrogenase activity [GO:0008465]; glyoxylate reductase (NADP+) activity [GO:0030267]; hydroxypyruvate reductase activity [GO:0016618]; NAD binding [GO:0051287] glycerate dehydrogenase activity [GO:0008465]; glyoxylate reductase (NADP+) activity [GO:0030267]; hydroxypyruvate reductase activity [GO:0016618]; NAD binding [GO:0051287] GO:0005829; GO:0005886; GO:0008465; GO:0016618; GO:0030267; GO:0051287 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:11237876}. +P0AER3 GLTJ_ECOLI Glutamate/aspartate import permease protein GltJ gltJ b0654 JW0649 gltJ 27,503 amino acid transport [GO:0006865] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; amino acid transport [GO:0006865] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0006865; GO:0022857; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P06715 GSHR_ECOLI Glutathione reductase (GR) (GRase) (EC 1.8.1.7) gor b3500 JW3467 gor 48,773 cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; glutathione metabolic process [GO:0006749] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; glutathione-disulfide reductase activity [GO:0004362]; NADP binding [GO:0050661]; cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; glutathione metabolic process [GO:0006749] FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; glutathione-disulfide reductase activity [GO:0004362]; NADP binding [GO:0050661] GO:0004362; GO:0005829; GO:0006749; GO:0016020; GO:0034599; GO:0045454; GO:0050660; GO:0050661; GO:0071949 SUBCELLULAR LOCATION: Cytoplasm. +P60595 HIS5_ECOLI Imidazole glycerol phosphate synthase subunit HisH (EC 4.3.2.10) (IGP synthase glutaminase subunit) (EC 3.5.1.2) (IGP synthase subunit HisH) (ImGP synthase subunit HisH) (IGPS subunit HisH) hisH b2023 JW2005 hisH 21,653 glutamine metabolic process [GO:0006541]; histidine biosynthetic process [GO:0000105] imidazoleglycerol-phosphate synthase complex [GO:0009382] imidazoleglycerol-phosphate synthase complex [GO:0009382]; glutaminase activity [GO:0004359]; imidazoleglycerol-phosphate synthase activity [GO:0000107]; lyase activity [GO:0016829]; glutamine metabolic process [GO:0006541]; histidine biosynthetic process [GO:0000105] glutaminase activity [GO:0004359]; imidazoleglycerol-phosphate synthase activity [GO:0000107]; lyase activity [GO:0016829] GO:0000105; GO:0000107; GO:0004359; GO:0006541; GO:0009382; GO:0016829 SUBCELLULAR LOCATION: Cytoplasm. +P76339 HPRS_ECOLI Sensor histidine kinase HprS (EC 2.7.13.3) (Hydrogen peroxide response sensor) hprS yedV b1968 JW1951 yedV hprS 50,850 cellular response to DNA damage stimulus [GO:0006974]; phosphorelay signal transduction system [GO:0000160] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; protein kinase activity [GO:0004672]; cellular response to DNA damage stimulus [GO:0006974]; phosphorelay signal transduction system [GO:0000160] ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; protein kinase activity [GO:0004672] GO:0000155; GO:0000160; GO:0004672; GO:0005524; GO:0005886; GO:0006974; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P46133 ABGT_ECOLI p-aminobenzoyl-glutamate transport protein (PABA-GLU transport protein) abgT ydaH b1336 JW5822 ECK1332 ydaH abgT 54,886 amino acid transport [GO:0006865]; p-aminobenzoyl-glutamate transmembrane transport [GO:1902604]; p-aminobenzoyl-glutamate transport [GO:0015814] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; secondary active p-aminobenzoyl-glutamate transmembrane transporter activity [GO:0015558]; secondary active transmembrane transporter activity [GO:0015291]; amino acid transport [GO:0006865]; p-aminobenzoyl-glutamate transmembrane transport [GO:1902604]; p-aminobenzoyl-glutamate transport [GO:0015814] secondary active p-aminobenzoyl-glutamate transmembrane transporter activity [GO:0015558]; secondary active transmembrane transporter activity [GO:0015291] GO:0005886; GO:0006865; GO:0015291; GO:0015558; GO:0015814; GO:0016021; GO:1902604 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0ABD5 ACCA_ECOLI Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (ACCase subunit alpha) (Acetyl-CoA carboxylase carboxyltransferase subunit alpha) (EC 2.1.3.15) accA b0185 JW0180 accA 35,242 fatty acid biosynthetic process [GO:0006633]; long-chain fatty acid biosynthetic process [GO:0042759]; malonyl-CoA biosynthetic process [GO:2001295] acetate CoA-transferase complex [GO:0009329]; cytoplasm [GO:0005737]; cytosol [GO:0005829] acetate CoA-transferase complex [GO:0009329]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; carboxyl- or carbamoyltransferase activity [GO:0016743]; identical protein binding [GO:0042802]; fatty acid biosynthetic process [GO:0006633]; long-chain fatty acid biosynthetic process [GO:0042759]; malonyl-CoA biosynthetic process [GO:2001295] acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; carboxyl- or carbamoyltransferase activity [GO:0016743]; identical protein binding [GO:0042802] GO:0003989; GO:0005524; GO:0005737; GO:0005829; GO:0006633; GO:0009329; GO:0016743; GO:0042759; GO:0042802; GO:2001295 SUBCELLULAR LOCATION: Cytoplasm. +P0A9Q7 ADHE_ECOLI Aldehyde-alcohol dehydrogenase [Includes: Alcohol dehydrogenase (ADH) (EC 1.1.1.1); Acetaldehyde dehydrogenase [acetylating] (ACDH) (EC 1.2.1.10); Pyruvate-formate-lyase deactivase (PFL deactivase)] adhE ana b1241 JW1228 ana adhE 96,127 carbon utilization [GO:0015976]; ethanol biosynthetic process [GO:0006115] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; acetaldehyde dehydrogenase (acetylating) activity [GO:0008774]; alcohol dehydrogenase (NAD+) activity [GO:0004022]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; carbon utilization [GO:0015976]; ethanol biosynthetic process [GO:0006115] acetaldehyde dehydrogenase (acetylating) activity [GO:0008774]; alcohol dehydrogenase (NAD+) activity [GO:0004022]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] GO:0004022; GO:0005829; GO:0006115; GO:0008774; GO:0015976; GO:0016020; GO:0042802; GO:0046872 +P31801 CHAA_ECOLI Sodium-potassium/proton antiporter ChaA (Na(+)/H(+) exchanger) chaA b1216 JW1207 chaA 39,168 cellular potassium ion homeostasis [GO:0030007]; cellular sodium ion homeostasis [GO:0006883]; sodium ion transport [GO:0006814] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; cellular potassium ion homeostasis [GO:0030007]; cellular sodium ion homeostasis [GO:0006883]; sodium ion transport [GO:0006814] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385] GO:0005886; GO:0005887; GO:0006814; GO:0006883; GO:0015385; GO:0015386; GO:0030007 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P03004 DNAA_ECOLI Chromosomal replication initiator protein DnaA dnaA b3702 JW3679 dnaA 52,551 DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; negative regulation of DNA replication [GO:0008156]; regulation of DNA replication [GO:0006275] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA replication origin binding [GO:0003688]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; negative regulation of DNA replication [GO:0008156]; regulation of DNA replication [GO:0006275] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA replication origin binding [GO:0003688]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565] GO:0003677; GO:0003688; GO:0005524; GO:0005829; GO:0005886; GO:0006260; GO:0006270; GO:0006275; GO:0008156; GO:0009898; GO:0042802; GO:0043565 SUBCELLULAR LOCATION: Cytoplasm. +Q46857 DKGA_ECOLI 2,5-diketo-D-gluconic acid reductase A (2,5-DKG reductase A) (2,5-DKGR A) (25DKGR-A) (EC 1.1.1.274) (AKR5C) dkgA yqhE b3012 JW5499 yqhE dkgA 31,110 L-ascorbic acid biosynthetic process [GO:0019853]; methylglyoxal catabolic process [GO:0051596] cytosol [GO:0005829] cytosol [GO:0005829]; 2,5-didehydrogluconate reductase activity [GO:0050580]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; D-threo-aldose 1-dehydrogenase activity [GO:0047834]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; L-ascorbic acid biosynthetic process [GO:0019853]; methylglyoxal catabolic process [GO:0051596] 2,5-didehydrogluconate reductase activity [GO:0050580]; alcohol dehydrogenase (NADP+) activity [GO:0008106]; alditol:NADP+ 1-oxidoreductase activity [GO:0004032]; D-threo-aldose 1-dehydrogenase activity [GO:0047834]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] GO:0004032; GO:0005829; GO:0008106; GO:0016616; GO:0019853; GO:0047834; GO:0050580; GO:0051596 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P46889 FTSK_ECOLI DNA translocase FtsK ftsK b0890 JW0873 ftsK 146,663 cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to antibiotic [GO:0071236]; chromosome segregation [GO:0007059]; positive regulation of catalytic activity [GO:0043085]; positive regulation of transcription, DNA-templated [GO:0045893]; response to osmotic stress [GO:0006970]; response to salt stress [GO:0009651]; septum digestion after cytokinesis [GO:0000920] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; DNA binding [GO:0003677]; DNA translocase activity [GO:0015616]; double-stranded DNA helicase activity [GO:0036121]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to antibiotic [GO:0071236]; chromosome segregation [GO:0007059]; positive regulation of catalytic activity [GO:0043085]; positive regulation of transcription, DNA-templated [GO:0045893]; response to osmotic stress [GO:0006970]; response to salt stress [GO:0009651]; septum digestion after cytokinesis [GO:0000920] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA translocase activity [GO:0015616]; double-stranded DNA helicase activity [GO:0036121]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565] GO:0000920; GO:0003677; GO:0005524; GO:0005886; GO:0005887; GO:0006970; GO:0007049; GO:0007059; GO:0009651; GO:0015616; GO:0016020; GO:0016887; GO:0036121; GO:0042802; GO:0043085; GO:0043565; GO:0045893; GO:0051301; GO:0071236 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:11703663, ECO:0000269|PubMed:11948172, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:25002583, ECO:0000269|PubMed:9723913}; Multi-pass membrane protein {ECO:0000269|PubMed:11703663, ECO:0000269|PubMed:11948172, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:25002583, ECO:0000269|PubMed:9723913}. Note=Located at the septum. Colocalizes with FtsZ. ZipA, FtsZ and FtsA, but not FtsI and FtsQ are required to target it to the septum. +Q46839 GLCA_ECOLI Glycolate permease GlcA glcA yghK b2975 JW2942 yghK glcA 58,920 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; lactate transmembrane transporter activity [GO:0015129]; solute:proton symporter activity [GO:0015295] lactate transmembrane transporter activity [GO:0015129]; solute:proton symporter activity [GO:0015295] GO:0005886; GO:0005887; GO:0015129; GO:0015295 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P75993 ARIR_ECOLI Probable two-component-system connector protein AriR ariR ymgB b1166 JW1153 ymgB ariR 9,694 cellular response to acidic pH [GO:0071468]; response to hydrogen peroxide [GO:0042542] DNA binding [GO:0003677]; cellular response to acidic pH [GO:0071468]; response to hydrogen peroxide [GO:0042542] DNA binding [GO:0003677] GO:0003677; GO:0042542; GO:0071468 +P76473 ARNT_ECOLI Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase (EC 2.4.2.43) (4-amino-4-deoxy-L-arabinose lipid A transferase) (Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase) (Polymyxin resistance protein PmrK) (Undecaprenyl phosphate-alpha-L-Ara4N transferase) arnT pmrK yfbI b2257 JW2251 pmrK yfbI arnT 62,543 lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; protein O-linked glycosylation [GO:0006493]; response to iron(III) ion [GO:0010041] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; 4-amino-4-deoxy-L-arabinose transferase activity [GO:0103015]; mannosyltransferase activity [GO:0000030]; transferase activity, transferring pentosyl groups [GO:0016763]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; protein O-linked glycosylation [GO:0006493]; response to iron(III) ion [GO:0010041] 4-amino-4-deoxy-L-arabinose transferase activity [GO:0103015]; mannosyltransferase activity [GO:0000030]; transferase activity, transferring pentosyl groups [GO:0016763] GO:0000030; GO:0005886; GO:0006493; GO:0009103; GO:0009245; GO:0010041; GO:0016021; GO:0016763; GO:0103015 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P31456 CBRA_ECOLI Protein CbrA (CreB-regulated gene A protein) cbrA yidS b3690 JW5631 yidS cbrA 40,142 bacteriocin immunity [GO:0030153] FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; bacteriocin immunity [GO:0030153] FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660] GO:0030153; GO:0050660; GO:0071949 +P76364 CBEA_ECOLI Cytoskeleton bundling-enhancing antitoxin CbeA (Antitoxin CbeA) (Antitoxin YeeU) cbeA yeeU b2004 JW1986 yeeU cbeA 13,684 positive regulation of cytoskeleton organization [GO:0051495] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; cytoskeletal protein binding [GO:0008092]; metal ion binding [GO:0046872]; positive regulation of cytoskeleton organization [GO:0051495] cytoskeletal protein binding [GO:0008092]; metal ion binding [GO:0046872] GO:0005737; GO:0008092; GO:0046872; GO:0051495 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P00864 CAPP_ECOLI Phosphoenolpyruvate carboxylase (PEPC) (PEPCase) (EC 4.1.1.31) ppc glu b3956 JW3928 glu ppc 99,063 carbon fixation [GO:0015977]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829] cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; phosphoenolpyruvate carboxylase activity [GO:0008964]; carbon fixation [GO:0015977]; oxaloacetate metabolic process [GO:0006107]; tricarboxylic acid cycle [GO:0006099] magnesium ion binding [GO:0000287]; phosphoenolpyruvate carboxylase activity [GO:0008964] GO:0000287; GO:0005829; GO:0006099; GO:0006107; GO:0008964; GO:0015977 +P23890 CADC_ECOLI Transcriptional activator CadC cadC b4133 JW4094 cadC 57,813 positive regulation of transcription, DNA-templated [GO:0045893] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein-DNA complex [GO:0032993]; DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; positive regulation of transcription, DNA-templated [GO:0045893] DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000976; GO:0001216; GO:0005829; GO:0005886; GO:0016021; GO:0032993; GO:0045893 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P64467 CNU_ECOLI OriC-binding nucleoid-associated protein (H-NS/StpA-binding protein 2) (Transcription modulator YdgT) cnu ydgT b1625 JW1617 ydgT cnu 8,417 negative regulation of single-species biofilm formation on inanimate substrate [GO:1900232]; positive regulation of DNA-templated transcription, termination [GO:0060566] DNA binding [GO:0003677]; negative regulation of single-species biofilm formation on inanimate substrate [GO:1900232]; positive regulation of DNA-templated transcription, termination [GO:0060566] DNA binding [GO:0003677] GO:0003677; GO:0060566; GO:1900232 +P0A9G4 CUER_ECOLI HTH-type transcriptional regulator CueR (Copper efflux regulator) (Copper export regulator) cueR copR ybbI b0487 JW0476 copR ybbI cueR 15,235 positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] cytoplasm [GO:0005737]; protein-DNA complex [GO:0032993] cytoplasm [GO:0005737]; protein-DNA complex [GO:0032993]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; copper ion binding [GO:0005507]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; copper ion binding [GO:0005507]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0000986; GO:0001216; GO:0003700; GO:0005507; GO:0005737; GO:0006351; GO:0032993; GO:0042802; GO:0045893 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P27111 CYNR_ECOLI HTH-type transcriptional regulator CynR (Cyn operon transcriptional activator) cynR b0338 JW5894 cynR 32,961 regulation of transcription, DNA-templated [GO:0006355] cytoplasm [GO:0005737]; protein-DNA complex [GO:0032993] cytoplasm [GO:0005737]; protein-DNA complex [GO:0032993]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700] GO:0000986; GO:0003700; GO:0005737; GO:0006355; GO:0032993 SUBCELLULAR LOCATION: Cytoplasm. +P77485 CUSS_ECOLI Sensor histidine kinase CusS (EC 2.7.13.3) cusS ybcZ b0570 JW5082 ybcZ cusS 53,738 cellular response to copper ion [GO:0071280]; cellular response to silver ion [GO:0071292]; peptidyl-histidine phosphorylation [GO:0018106]; phosphorelay signal transduction system [GO:0000160]; phosphorylation [GO:0016310]; signal transduction [GO:0007165] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673]; cellular response to copper ion [GO:0071280]; cellular response to silver ion [GO:0071292]; peptidyl-histidine phosphorylation [GO:0018106]; phosphorelay signal transduction system [GO:0000160]; phosphorylation [GO:0016310]; signal transduction [GO:0007165] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673] GO:0000155; GO:0000160; GO:0004673; GO:0005524; GO:0005886; GO:0005887; GO:0007165; GO:0016020; GO:0016310; GO:0018106; GO:0046872; GO:0071280; GO:0071292 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P27838 CYAY_ECOLI Iron-sulfur cluster assembly protein CyaY (Bacterial frataxin ortholog) cyaY b3807 JW3779 cyaY 12,231 iron-sulfur cluster assembly [GO:0016226] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; iron-sulfur cluster assembly [GO:0016226] ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198] GO:0005737; GO:0005829; GO:0008198; GO:0008199; GO:0016226 +P0ABP3 DCUC_ECOLI Anaerobic C4-dicarboxylate transporter DcuC dcuC b0621 JW0613/JW0616 dcuC 48,412 C4-dicarboxylate transport [GO:0015740]; mixed acid fermentation [GO:0019664] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; succinate:fumarate antiporter activity [GO:0005469]; C4-dicarboxylate transport [GO:0015740]; mixed acid fermentation [GO:0019664] succinate:fumarate antiporter activity [GO:0005469] GO:0005469; GO:0005886; GO:0005887; GO:0015740; GO:0019664 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P45428 DCUD_ECOLI Putative cryptic C4-dicarboxylate transporter DcuD dcuD yhcL b3227 JW3196 yhcL dcuD 48,831 anaerobic glycerol catabolic process [GO:0019588]; C4-dicarboxylate transport [GO:0015740] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; C4-dicarboxylate transmembrane transporter activity [GO:0015556]; anaerobic glycerol catabolic process [GO:0019588]; C4-dicarboxylate transport [GO:0015740] C4-dicarboxylate transmembrane transporter activity [GO:0015556] GO:0005886; GO:0005887; GO:0015556; GO:0015740; GO:0019588 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76128 DDPA_ECOLI Probable D,D-dipeptide-binding periplasmic protein DdpA ddpA yddS b1487 JW5240 yddS ddpA 57,641 peptide transport [GO:0015833]; protein transport [GO:0015031] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288]; peptide transmembrane transporter activity [GO:1904680]; peptide transport [GO:0015833]; protein transport [GO:0015031] peptide transmembrane transporter activity [GO:1904680] GO:0015031; GO:0015833; GO:0030288; GO:0043190; GO:1904680 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P08506 DACC_ECOLI D-alanyl-D-alanine carboxypeptidase DacC (DD-carboxypeptidase) (DD-peptidase) (EC 3.4.16.4) (Penicillin-binding protein 6) (PBP-6) dacC b0839 JW0823 dacC 43,609 cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to drug [GO:0042493] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; carboxypeptidase activity [GO:0004180]; penicillin binding [GO:0008658]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to drug [GO:0042493] carboxypeptidase activity [GO:0004180]; penicillin binding [GO:0008658]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002] GO:0004180; GO:0005886; GO:0005887; GO:0008360; GO:0008658; GO:0009002; GO:0009252; GO:0030288; GO:0042493; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:3330754}; Peripheral membrane protein {ECO:0000269|PubMed:3330754}; Periplasmic side {ECO:0000269|PubMed:3330754}. Note=N-terminus lies in the periplasmic space, targeted there by the C-terminal amphiphilic helix (PMID:3330754). +P0ADB4 ECNA_ECOLI Entericidin A ecnA b4410 JW5737 ecnA 4,359 response to toxic substance [GO:0009636] membrane [GO:0016020]; plasma membrane [GO:0005886] membrane [GO:0016020]; plasma membrane [GO:0005886]; response to toxic substance [GO:0009636] GO:0005886; GO:0009636; GO:0016020 SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. +P0AAP1 DGCC_ECOLI Probable diguanylate cyclase DgcC (DGC) (EC 2.7.7.65) dgcC adrA yaiC b0385 JW0376 adrA yaiC dgcC 41,537 cell adhesion involved in single-species biofilm formation [GO:0043709]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; cell adhesion involved in single-species biofilm formation [GO:0043709]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201] diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872] GO:0005525; GO:0005886; GO:0016021; GO:0043709; GO:0046872; GO:0052621; GO:1902201 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P77802 ECPC_ECOLI Probable outer membrane usher protein EcpC ecpC matD yagX b0291 JW0285 matD yagX ecpC 91,229 +P46068 DSDC_ECOLI HTH-type transcriptional regulator DsdC (D-serine deaminase activator) dsdC b2364 JW2361 dsdC 35,332 transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0006351; GO:0043565 +P10378 ENTE_ECOLI Enterobactin synthase component E (EC 6.3.2.14) (2,3-dihydroxybenzoate-AMP ligase) (DHB-AMP ligase) (2,3-dihydroxybenzoate-AMP synthase) (EC 2.7.7.58) (Dihydroxybenzoic acid-activating enzyme) (Enterochelin synthase E) (S-dihydroxybenzoyltransferase) (EC 2.5.1.-) entE b0594 JW0586 entE 59,112 enterobactin biosynthetic process [GO:0009239] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; (2,3-dihydroxybenzoyl)adenylate synthase activity [GO:0008668]; 2,3-dihydroxybenzoate-serine ligase activity [GO:0047527]; ATP binding [GO:0005524]; transferase activity, transferring acyl groups [GO:0016746]; enterobactin biosynthetic process [GO:0009239] (2,3-dihydroxybenzoyl)adenylate synthase activity [GO:0008668]; 2,3-dihydroxybenzoate-serine ligase activity [GO:0047527]; ATP binding [GO:0005524]; transferase activity, transferring acyl groups [GO:0016746] GO:0005524; GO:0005829; GO:0008668; GO:0009239; GO:0016020; GO:0016746; GO:0047527 SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10692387}. +P15081 GUTM_ECOLI Glucitol operon activator protein gutM srlM b2706 JW2675 srlM gutM 12,953 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677] GO:0003677; GO:0006355; GO:0009401 +P0A8R9 HDFR_ECOLI HTH-type transcriptional regulator HdfR (H-NS-dependent flhDC regulator) hdfR pssR yifA yifD b4480 JW5607 pssR yifA yifD hdfR 31,746 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006355; GO:0045892 +P42601 ALX_ECOLI Putative membrane-bound redox modulator Alx alx ygjT b3088 JW5515 ygjT alx 35,909 cellular response to pH [GO:0071467] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cellular response to pH [GO:0071467] GO:0005886; GO:0016021; GO:0071467 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P77256 AKRMG_ECOLI NADH-specific methylglyoxal reductase (EC 1.1.1.-) (AKR11B2) ydjG b1771 JW1760 ydjG 36,329 cytosol [GO:0005829] cytosol [GO:0005829]; D-threo-aldose 1-dehydrogenase activity [GO:0047834]; ethylglyoxal reductase (NADH-dependent, hydroxyacetone-forming) activity [GO:0103030]; methylglyoxal reductase (NADH-dependent) activity [GO:0019170] D-threo-aldose 1-dehydrogenase activity [GO:0047834]; ethylglyoxal reductase (NADH-dependent, hydroxyacetone-forming) activity [GO:0103030]; methylglyoxal reductase (NADH-dependent) activity [GO:0019170] GO:0005829; GO:0019170; GO:0047834; GO:0103030 +P75712 ALLP_ECOLI Putative allantoin permease (Allantoin transport protein) ybbW glxB2 b0511 JW0499 glxB2 ybbW 52,456 nucleobase transport [GO:0015851]; purine nucleobase metabolic process [GO:0006144] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; nucleobase transmembrane transporter activity [GO:0015205]; nucleobase transport [GO:0015851]; purine nucleobase metabolic process [GO:0006144] nucleobase transmembrane transporter activity [GO:0015205] GO:0005886; GO:0006144; GO:0015205; GO:0015851; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P33224 AIDB_ECOLI Putative acyl-CoA dehydrogenase AidB (EC 1.3.99.-) aidB b4187 JW5867 aidB 60,590 cellular response to DNA damage stimulus [GO:0006974]; negative regulation of transcription, DNA-templated [GO:0045892] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; isovaleryl-CoA dehydrogenase activity [GO:0008470]; sequence-specific DNA binding [GO:0043565]; cellular response to DNA damage stimulus [GO:0006974]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; identical protein binding [GO:0042802]; isovaleryl-CoA dehydrogenase activity [GO:0008470]; sequence-specific DNA binding [GO:0043565] GO:0003677; GO:0005737; GO:0006974; GO:0008470; GO:0042802; GO:0043565; GO:0045892 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P39265 ALSB_ECOLI D-allose-binding periplasmic protein (ALBP) alsB yjcX b4088 JW4049 yjcX alsB 32,910 carbohydrate transport [GO:0008643] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; monosaccharide binding [GO:0048029]; carbohydrate transport [GO:0008643] monosaccharide binding [GO:0048029] GO:0008643; GO:0016020; GO:0030288; GO:0048029 SUBCELLULAR LOCATION: Periplasm. +P0AB85 APBE_ECOLI FAD:protein FMN transferase (EC 2.7.1.180) (Flavin transferase) apbE yojK yojL b2214 JW5368 yojK yojL apbE 38,549 protein flavinylation [GO:0017013] intrinsic component of periplasmic side of plasma membrane [GO:0031237]; outer membrane-bounded periplasmic space [GO:0030288] intrinsic component of periplasmic side of plasma membrane [GO:0031237]; outer membrane-bounded periplasmic space [GO:0030288]; FAD binding [GO:0071949]; metal ion binding [GO:0046872]; transferase activity [GO:0016740]; protein flavinylation [GO:0017013] FAD binding [GO:0071949]; metal ion binding [GO:0046872]; transferase activity [GO:0016740] GO:0016740; GO:0017013; GO:0030288; GO:0031237; GO:0046872; GO:0071949 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:P41780, ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000250|UniProtKB:P41780, ECO:0000255|PROSITE-ProRule:PRU00303}; Periplasmic side {ECO:0000250|UniProtKB:P41780}. +P22106 ASNB_ECOLI Asparagine synthetase B [glutamine-hydrolyzing] (AS-B) (EC 6.3.5.4) asnB b0674 JW0660 asnB 62,659 asparagine biosynthetic process [GO:0006529]; cellular amino acid biosynthetic process [GO:0008652]; cellular amino acid catabolic process [GO:0009063]; glutamine metabolic process [GO:0006541]; L-asparagine biosynthetic process [GO:0070981] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; amino acid binding [GO:0016597]; asparagine synthase (glutamine-hydrolyzing) activity [GO:0004066]; aspartate-ammonia ligase activity [GO:0004071]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; asparagine biosynthetic process [GO:0006529]; cellular amino acid biosynthetic process [GO:0008652]; cellular amino acid catabolic process [GO:0009063]; glutamine metabolic process [GO:0006541]; L-asparagine biosynthetic process [GO:0070981] amino acid binding [GO:0016597]; asparagine synthase (glutamine-hydrolyzing) activity [GO:0004066]; aspartate-ammonia ligase activity [GO:0004071]; ATP binding [GO:0005524]; identical protein binding [GO:0042802] GO:0004066; GO:0004071; GO:0005524; GO:0005737; GO:0005829; GO:0006529; GO:0006541; GO:0008652; GO:0009063; GO:0016597; GO:0042802; GO:0070981 +P0AD14 BTSS_ECOLI Sensor histidine kinase BtsS (EC 2.7.13.3) btsS yehU b2126 JW5353 yehU btsS 62,092 cell wall organization [GO:0071555]; peptidyl-histidine phosphorylation [GO:0018106]; response to nutrient levels [GO:0031667]; signal transduction [GO:0007165] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; cell wall organization [GO:0071555]; peptidyl-histidine phosphorylation [GO:0018106]; response to nutrient levels [GO:0031667]; signal transduction [GO:0007165] ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155] GO:0000155; GO:0005524; GO:0005886; GO:0005887; GO:0007165; GO:0018106; GO:0031667; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P06611 BTUD_ECOLI Vitamin B12 import ATP-binding protein BtuD (EC 7.6.2.8) (Vitamin B12-transporting ATPase) btuD b1709 JW1699 btuD 27,081 cobalamin transport [GO:0015889] ATP-binding cassette (ABC) transporter complex [GO:0043190]; extrinsic component of membrane [GO:0019898] ATP-binding cassette (ABC) transporter complex [GO:0043190]; extrinsic component of membrane [GO:0019898]; ABC-type vitamin B12 transporter activity [GO:0015420]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cobalamin transport [GO:0015889] ABC-type vitamin B12 transporter activity [GO:0015420]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0015420; GO:0015889; GO:0019898; GO:0042626; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. +P21179 CATE_ECOLI Catalase HPII (EC 1.11.1.6) (Hydroxyperoxidase II) katE b1732 JW1721 katE 84,163 cellular response to DNA damage stimulus [GO:0006974]; hydrogen peroxide catabolic process [GO:0042744]; hyperosmotic response [GO:0006972]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; catalase activity [GO:0004096]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; cellular response to DNA damage stimulus [GO:0006974]; hydrogen peroxide catabolic process [GO:0042744]; hyperosmotic response [GO:0006972]; response to oxidative stress [GO:0006979] catalase activity [GO:0004096]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506] GO:0004096; GO:0005506; GO:0005737; GO:0005829; GO:0006972; GO:0006974; GO:0006979; GO:0020037; GO:0042744; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P06961 CCA_ECOLI Multifunctional CCA protein [Includes: CCA-adding enzyme (EC 2.7.7.72) (CCA tRNA nucleotidyltransferase) (tRNA CCA-pyrophosphorylase) (tRNA adenylyl-/cytidylyl-transferase) (tRNA nucleotidyltransferase) (tRNA-NT); 2'-nucleotidase (EC 3.1.3.-); 2',3'-cyclic phosphodiesterase (EC 3.1.4.-); Phosphatase (EC 3.1.3.-)] cca b3056 JW3028 cca 46,467 RNA repair [GO:0042245]; tRNA 3'-terminal CCA addition [GO:0001680] ATP binding [GO:0005524]; ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity [GO:0052929]; CTP:3'-cytidine-tRNA cytidylyltransferase activity [GO:0052928]; CTP:tRNA cytidylyltransferase activity [GO:0052927]; cyclic-nucleotide phosphodiesterase activity [GO:0004112]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; tRNA adenylyltransferase activity [GO:0004810]; tRNA binding [GO:0000049]; tRNA cytidylyltransferase activity [GO:0016437]; RNA repair [GO:0042245]; tRNA 3'-terminal CCA addition [GO:0001680] ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity [GO:0052929]; ATP binding [GO:0005524]; CTP:3'-cytidine-tRNA cytidylyltransferase activity [GO:0052928]; CTP:tRNA cytidylyltransferase activity [GO:0052927]; cyclic-nucleotide phosphodiesterase activity [GO:0004112]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; tRNA adenylyltransferase activity [GO:0004810]; tRNA binding [GO:0000049]; tRNA cytidylyltransferase activity [GO:0016437] GO:0000049; GO:0000287; GO:0001680; GO:0004112; GO:0004810; GO:0005524; GO:0016437; GO:0016791; GO:0042245; GO:0052927; GO:0052928; GO:0052929 +P0AE58 CAIF_ECOLI Transcriptional activatory protein CaiF caiF b0034 JW0033 caiF 15,436 carnitine metabolic process [GO:0009437]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; carnitine metabolic process [GO:0009437]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700] GO:0003700; GO:0006351; GO:0006355; GO:0009437 +P76345 C56H_ECOLI Cytochrome b561 homolog 1 yodB b1974 JW5323 yodB 20,337 respiratory electron transport chain [GO:0022904] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; respiratory electron transport chain [GO:0022904] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872] GO:0005886; GO:0009055; GO:0016021; GO:0020037; GO:0022904; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A6F9 CH10_ECOLI 10 kDa chaperonin (GroES protein) (Protein Cpn10) groS groES mopB b4142 JW4102 groES mopB groS 10,387 cell cycle [GO:0007049]; cell division [GO:0051301]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein folding [GO:0006457]; response to heat [GO:0009408]; virion assembly [GO:0019068] cytosol [GO:0005829]; GroEL-GroES complex [GO:1990220] cytosol [GO:0005829]; GroEL-GroES complex [GO:1990220]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; chaperone binding [GO:0051087]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; unfolded protein binding [GO:0051082]; cell cycle [GO:0007049]; cell division [GO:0051301]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein folding [GO:0006457]; response to heat [GO:0009408]; virion assembly [GO:0019068] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; chaperone binding [GO:0051087]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; unfolded protein binding [GO:0051082] GO:0005524; GO:0005829; GO:0006457; GO:0007049; GO:0009408; GO:0016887; GO:0019068; GO:0042802; GO:0046872; GO:0051082; GO:0051085; GO:0051087; GO:0051301; GO:1990220 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22380631}. Note=Exclusively localized in foci, usually near 1 cell pole in mid-to-late exponential phase; polar localization depends on the minCDE operon. Foci form near midcell. +P76236 CDGI_ECOLI Probable diguanylate cyclase CdgI (DGC) (EC 2.7.7.65) cdgI yeaI b1785 JW1774 yeaI cdgI 56,101 cell adhesion involved in single-species biofilm formation [GO:0043709]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; cell adhesion involved in single-species biofilm formation [GO:0043709]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201] diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872] GO:0005525; GO:0005886; GO:0016021; GO:0043709; GO:0046872; GO:0052621; GO:1902201 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P0AC92 GNSA_ECOLI Protein GnsA gnsA yccL b4517 JW0976 yccL gnsA 6,576 cytosol [GO:0005829] cytosol [GO:0005829]; identical protein binding [GO:0042802] identical protein binding [GO:0042802] GO:0005829; GO:0042802 +P04079 GUAA_ECOLI GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (GMPS) (Glutamine amidotransferase) guaA b2507 JW2491 guaA 58,679 glutamine metabolic process [GO:0006541]; GMP biosynthetic process [GO:0006177] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; GMP synthase (glutamine-hydrolyzing) activity [GO:0003922]; GMP synthase activity [GO:0003921]; identical protein binding [GO:0042802]; pyrophosphatase activity [GO:0016462]; glutamine metabolic process [GO:0006541]; GMP biosynthetic process [GO:0006177] ATP binding [GO:0005524]; GMP synthase (glutamine-hydrolyzing) activity [GO:0003922]; GMP synthase activity [GO:0003921]; identical protein binding [GO:0042802]; pyrophosphatase activity [GO:0016462] GO:0003921; GO:0003922; GO:0005524; GO:0005829; GO:0006177; GO:0006541; GO:0016462; GO:0042802 +P0AET2 HDEB_ECOLI Acid stress chaperone HdeB (10K-L protein) hdeB yhhD yhiC b3509 JW5669 yhhD yhiC hdeB 12,043 cellular stress response to acidic pH [GO:1990451]; response to acidic pH [GO:0010447] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; unfolded protein binding [GO:0051082]; cellular stress response to acidic pH [GO:1990451]; response to acidic pH [GO:0010447] unfolded protein binding [GO:0051082] GO:0010447; GO:0030288; GO:0051082; GO:1990451 SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00947, ECO:0000269|PubMed:17085547}. +P45751 HOFO_ECOLI DNA utilization protein HofO hofO yrfB b3393 JW3356 yrfB hofO 16,846 carbon utilization [GO:0015976]; DNA catabolic process [GO:0006308] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; carbon utilization [GO:0015976]; DNA catabolic process [GO:0006308] GO:0005886; GO:0006308; GO:0015976; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P71229 HYFR_ECOLI DNA-binding transcriptional activator HyfR (Hydrogenase-4 transcriptional activator) hyfR b2491 JW2476 hyfR 75,305 DNA-templated transcription, initiation [GO:0006352]; phosphorelay signal transduction system [GO:0000160]; regulation of DNA-templated transcription, initiation [GO:2000142] ATP binding [GO:0005524]; DNA binding [GO:0003677]; transcription factor binding [GO:0008134]; DNA-templated transcription, initiation [GO:0006352]; phosphorelay signal transduction system [GO:0000160]; regulation of DNA-templated transcription, initiation [GO:2000142] ATP binding [GO:0005524]; DNA binding [GO:0003677]; transcription factor binding [GO:0008134] GO:0000160; GO:0003677; GO:0005524; GO:0006352; GO:0008134; GO:2000142 +P08401 CREC_ECOLI Sensor protein CreC (EC 2.7.13.3) creC phoM b4399 JW4362 phoM creC 52,176 glycolytic fermentation [GO:0019660]; peptidyl-histidine phosphorylation [GO:0018106]; protein autophosphorylation [GO:0046777] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; glycolytic fermentation [GO:0019660]; peptidyl-histidine phosphorylation [GO:0018106]; protein autophosphorylation [GO:0046777] ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155] GO:0000155; GO:0005524; GO:0005886; GO:0005887; GO:0018106; GO:0019660; GO:0046777 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +Q59385 COPA_ECOLI Copper-exporting P-type ATPase (EC 7.2.2.8) (Copper-exporting P-type ATPase A) (Cu(+)-exporting ATPase) (Soluble copper chaperone CopA(Z)) copA atcU f834 ybaR b0484 JW0473 atcU f834 ybaR copA 87,873 cellular response to copper ion [GO:0071280]; cellular response to silver ion [GO:0071292]; copper ion export [GO:0060003]; copper ion transport [GO:0006825]; detoxification of copper ion [GO:0010273]; silver ion transmembrane transport [GO:1902601] cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ion transmembrane transporter activity, phosphorylative mechanism [GO:0015662]; metal ion binding [GO:0046872]; P-type divalent copper transporter activity [GO:0043682]; P-type monovalent copper transporter activity [GO:0140581]; silver ion transmembrane transporter activity [GO:0015080]; cellular response to copper ion [GO:0071280]; cellular response to silver ion [GO:0071292]; copper ion export [GO:0060003]; copper ion transport [GO:0006825]; detoxification of copper ion [GO:0010273]; silver ion transmembrane transport [GO:1902601] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; ion transmembrane transporter activity, phosphorylative mechanism [GO:0015662]; metal ion binding [GO:0046872]; P-type divalent copper transporter activity [GO:0043682]; P-type monovalent copper transporter activity [GO:0140581]; silver ion transmembrane transporter activity [GO:0015080] GO:0005524; GO:0005737; GO:0005886; GO:0005887; GO:0006825; GO:0010273; GO:0015080; GO:0015662; GO:0016020; GO:0016021; GO:0016887; GO:0043682; GO:0046872; GO:0060003; GO:0071280; GO:0071292; GO:0140581; GO:1902601 SUBCELLULAR LOCATION: [Copper-exporting P-type ATPase]: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000305|PubMed:12351646}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}.; SUBCELLULAR LOCATION: [Isoform Soluble copper chaperone CopA(Z)]: Cytoplasm {ECO:0000305|PubMed:28107647}. +P0ABJ6 CYOD_ECOLI Cytochrome bo(3) ubiquinol oxidase subunit 4 (Cytochrome o ubiquinol oxidase subunit 4) (Cytochrome o subunit 4) (Oxidase bo(3) subunit 4) (Ubiquinol oxidase chain D) (Ubiquinol oxidase polypeptide IV) (Ubiquinol oxidase subunit 4) cyoD b0429 JW0419 cyoD 12,029 aerobic electron transport chain [GO:0019646]; aerobic respiration [GO:0009060]; electron transport coupled proton transport [GO:0015990] cytochrome o ubiquinol oxidase complex [GO:0009319]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cytochrome o ubiquinol oxidase complex [GO:0009319]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cytochrome bo3 ubiquinol oxidase activity [GO:0009486]; cytochrome o ubiquinol oxidase activity [GO:0008827]; electron transfer activity [GO:0009055]; oxidoreduction-driven active transmembrane transporter activity [GO:0015453]; proton transmembrane transporter activity [GO:0015078]; aerobic electron transport chain [GO:0019646]; aerobic respiration [GO:0009060]; electron transport coupled proton transport [GO:0015990] cytochrome bo3 ubiquinol oxidase activity [GO:0009486]; cytochrome o ubiquinol oxidase activity [GO:0008827]; electron transfer activity [GO:0009055]; oxidoreduction-driven active transmembrane transporter activity [GO:0015453]; proton transmembrane transporter activity [GO:0015078] GO:0005886; GO:0005887; GO:0008827; GO:0009055; GO:0009060; GO:0009319; GO:0009486; GO:0015078; GO:0015453; GO:0015990; GO:0019646 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AED9 DCM_ECOLI DNA-cytosine methyltransferase (EC 2.1.1.37) (M.EcoDcm) dcm mec b1961 JW1944 mec dcm 53,465 C-5 methylation of cytosine [GO:0090116]; DNA restriction-modification system [GO:0009307] DNA (cytosine-5-)-methyltransferase activity [GO:0003886]; C-5 methylation of cytosine [GO:0090116]; DNA restriction-modification system [GO:0009307] DNA (cytosine-5-)-methyltransferase activity [GO:0003886] GO:0003886; GO:0009307; GO:0090116 +P0A6M8 EFG_ECOLI Elongation factor G (EF-G) fusA far fus b3340 JW3302 far fus fusA 77,581 ribosome disassembly [GO:0032790] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746]; ribosome disassembly [GO:0032790] GTPase activity [GO:0003924]; GTP binding [GO:0005525]; translation elongation factor activity [GO:0003746] GO:0003746; GO:0003924; GO:0005525; GO:0005737; GO:0005829; GO:0032790 SUBCELLULAR LOCATION: Cytoplasm. +P45800 IGAA_ECOLI Putative membrane protein IgaA homolog yrfF b3398 JW3361 yrfF 79,490 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0ADG1 ILVM_ECOLI Acetolactate synthase isozyme 2 small subunit (EC 2.2.1.6) (ALS-II) (Acetohydroxy-acid synthase II small subunit) (AHAS-II) ilvM b3769 JW3742 ilvM 9,703 cellular amino acid biosynthetic process [GO:0008652]; isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] acetolactate synthase activity [GO:0003984]; cellular amino acid biosynthetic process [GO:0008652]; isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] acetolactate synthase activity [GO:0003984] GO:0003984; GO:0008652; GO:0009097; GO:0009099 +P0A6Y1 IHFB_ECOLI Integration host factor subunit beta (IHF-beta) ihfB himD hip b0912 JW0895 himD hip ihfB 10,651 conjugation [GO:0000746]; DNA recombination [GO:0006310]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351] chromosome [GO:0005694]; cytosol [GO:0005829] chromosome [GO:0005694]; cytosol [GO:0005829]; DNA binding [GO:0003677]; conjugation [GO:0000746]; DNA recombination [GO:0006310]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677] GO:0000746; GO:0003677; GO:0005694; GO:0005829; GO:0006310; GO:0006351; GO:0006355; GO:0006417 SUBCELLULAR LOCATION: Cytoplasm. +P0AEY8 MDFA_ECOLI Multidrug transporter MdfA (Chloramphenicol resistance pump Cmr) mdfA cmlA cmr b0842 JW0826 cmlA cmr mdfA 44,321 regulation of cellular pH [GO:0030641]; response to antibiotic [GO:0046677]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; xenobiotic transmembrane transporter activity [GO:0042910]; regulation of cellular pH [GO:0030641]; response to antibiotic [GO:0046677]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0005887; GO:0015385; GO:0015386; GO:0016021; GO:0030641; GO:0042910; GO:0046677; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +C1P607 IBSA_ECOLI Small toxic protein IbsA ibsA b4667 JW2058.1 ibsA 2,232 programmed cell death [GO:0012501] programmed cell death [GO:0012501] GO:0012501 +P31462 MDTL_ECOLI Multidrug resistance protein MdtL mdtL yidY b3710 JW3688 yidY mdtL 41,490 response to antibiotic [GO:0046677]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; xenobiotic transmembrane transporter activity [GO:0042910]; response to antibiotic [GO:0046677]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0005887; GO:0016021; GO:0042910; GO:0046677; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AEX9 MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (MMBP) (Maltodextrin-binding protein) (Maltose-binding protein) (MBP) malE b4034 JW3994 malE 43,388 carbohydrate transport [GO:0008643]; cell chemotaxis [GO:0060326]; cellular response to DNA damage stimulus [GO:0006974]; detection of maltose stimulus [GO:0034289]; maltodextrin transport [GO:0042956]; maltose transport [GO:0015768] ATP-binding cassette (ABC) transporter complex [GO:0043190]; ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] ATP-binding cassette (ABC) transporter complex [GO:0043190]; ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; carbohydrate transmembrane transporter activity [GO:0015144]; maltose binding [GO:1901982]; carbohydrate transport [GO:0008643]; cell chemotaxis [GO:0060326]; cellular response to DNA damage stimulus [GO:0006974]; detection of maltose stimulus [GO:0034289]; maltodextrin transport [GO:0042956]; maltose transport [GO:0015768] carbohydrate transmembrane transporter activity [GO:0015144]; maltose binding [GO:1901982] GO:0006974; GO:0008643; GO:0015144; GO:0015768; GO:0030288; GO:0034289; GO:0042597; GO:0042956; GO:0043190; GO:0055052; GO:0060326; GO:1901982 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:4215651}. +P39386 MDTM_ECOLI Multidrug resistance protein MdtM mdtM yjiO b4337 JW4300 yjiO mdtM 44,688 bile acid and bile salt transport [GO:0015721]; potassium ion export across plasma membrane [GO:0097623]; regulation of cellular pH [GO:0030641]; response to antibiotic [GO:0046677]; sodium ion export across plasma membrane [GO:0036376]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; bile acid transmembrane transporter activity [GO:0015125]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; xenobiotic transmembrane transporter activity [GO:0042910]; bile acid and bile salt transport [GO:0015721]; potassium ion export across plasma membrane [GO:0097623]; regulation of cellular pH [GO:0030641]; response to antibiotic [GO:0046677]; sodium ion export across plasma membrane [GO:0036376]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] bile acid transmembrane transporter activity [GO:0015125]; potassium:proton antiporter activity [GO:0015386]; sodium:proton antiporter activity [GO:0015385]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0015125; GO:0015385; GO:0015386; GO:0015721; GO:0016021; GO:0030641; GO:0036376; GO:0042910; GO:0046677; GO:0097623; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P32716 MDTN_ECOLI Multidrug resistance protein MdtN mdtN yjcR b4082 JW4043 yjcR mdtN 36,908 response to antibiotic [GO:0046677]; sulfathiazole transmembrane transport [GO:1902599]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; sulfathiazole transmembrane transporter activity [GO:0015546]; xenobiotic transmembrane transporter activity [GO:0042910]; response to antibiotic [GO:0046677]; sulfathiazole transmembrane transport [GO:1902599]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] sulfathiazole transmembrane transporter activity [GO:0015546]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0015546; GO:0016021; GO:0042910; GO:0046677; GO:1902599; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. +P32715 MDTO_ECOLI Multidrug resistance protein MdtO mdtO yjcQ b4081 JW4042 yjcQ mdtO 76,151 response to antibiotic [GO:0046677]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; response to antibiotic [GO:0046677]; transmembrane transport [GO:0055085] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857; GO:0046677; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P32714 MDTP_ECOLI Multidrug resistance outer membrane protein MdtP mdtP yjcP b4080 JW4041 yjcP mdtP 53,453 response to antibiotic [GO:0046677] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; efflux transmembrane transporter activity [GO:0015562]; response to antibiotic [GO:0046677] efflux transmembrane transporter activity [GO:0015562] GO:0009279; GO:0015562; GO:0016021; GO:0046677 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P33369 MDTQ_ECOLI Putative multidrug resistance outer membrane protein MdtQ mdtQ yohG yohH b2139 JW5838/JW5358 b2138 yohG yohH mdtQ 52,138 response to antibiotic [GO:0046677] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; efflux transmembrane transporter activity [GO:0015562]; response to antibiotic [GO:0046677] efflux transmembrane transporter activity [GO:0015562] GO:0009279; GO:0015562; GO:0016021; GO:0046677 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P62615 ISPE_ECOLI 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (EC 2.7.1.148) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) ispE ipk ychB b1208 JW1199 ipk ychB ispE 30,925 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; terpenoid biosynthetic process [GO:0016114] 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity [GO:0050515]; ATP binding [GO:0005524]; isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; terpenoid biosynthetic process [GO:0016114] 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity [GO:0050515]; ATP binding [GO:0005524] GO:0005524; GO:0016114; GO:0019288; GO:0050515 +P0CF44 INSC5_ECOLI Transposase InsC for insertion element IS2I insC5 b3044 JW3012 insC5 13,452 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0ABK5 CYSK_ECOLI Cysteine synthase A (CSase A) (EC 2.5.1.47) (O-acetylserine (thiol)-lyase A) (OAS-TL A) (O-acetylserine sulfhydrylase A) (S-carboxymethylcysteine synthase) (EC 4.5.1.5) (Sulfate starvation-induced protein 5) (SSI5) cysK cysZ b2414 JW2407 cysZ cysK 34,490 cellular amino acid biosynthetic process [GO:0008652]; cysteine biosynthetic process from serine [GO:0006535] cysteine synthase complex [GO:0009333]; cytoplasm [GO:0005737]; cytosol [GO:0005829] cysteine synthase complex [GO:0009333]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cysteine synthase activity [GO:0004124]; identical protein binding [GO:0042802]; L-cysteine desulfhydrase activity [GO:0080146]; pyridoxal phosphate binding [GO:0030170]; S-carboxymethylcysteine synthase activity [GO:0050272]; transferase activity [GO:0016740]; cellular amino acid biosynthetic process [GO:0008652]; cysteine biosynthetic process from serine [GO:0006535] cysteine synthase activity [GO:0004124]; identical protein binding [GO:0042802]; L-cysteine desulfhydrase activity [GO:0080146]; pyridoxal phosphate binding [GO:0030170]; S-carboxymethylcysteine synthase activity [GO:0050272]; transferase activity [GO:0016740] GO:0004124; GO:0005737; GO:0005829; GO:0006535; GO:0008652; GO:0009333; GO:0016740; GO:0030170; GO:0042802; GO:0050272; GO:0080146 +P77211 CUSC_ECOLI Cation efflux system protein CusC cusC ibeB ylcB b0572 JW0561 ibeB ylcB cusC 50,270 cellular copper ion homeostasis [GO:0006878]; copper ion export [GO:0060003]; detoxification of copper ion [GO:0010273]; protein homotrimerization [GO:0070207]; protein palmitoylation [GO:0018345]; response to copper ion [GO:0046688]; response to silver ion [GO:0010272] cell outer membrane [GO:0009279]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; pore complex [GO:0046930]; copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; diacylglycerol binding [GO:0019992]; efflux transmembrane transporter activity [GO:0015562]; porin activity [GO:0015288]; cellular copper ion homeostasis [GO:0006878]; copper ion export [GO:0060003]; detoxification of copper ion [GO:0010273]; protein homotrimerization [GO:0070207]; protein palmitoylation [GO:0018345]; response to copper ion [GO:0046688]; response to silver ion [GO:0010272] copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; diacylglycerol binding [GO:0019992]; efflux transmembrane transporter activity [GO:0015562]; porin activity [GO:0015288] GO:0005375; GO:0005507; GO:0006878; GO:0009279; GO:0010272; GO:0010273; GO:0015288; GO:0015562; GO:0018345; GO:0019992; GO:0046688; GO:0046930; GO:0060003; GO:0070207 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:21249122}; Multi-pass membrane protein {ECO:0000269|PubMed:21249122}. Cell outer membrane {ECO:0000269|PubMed:21249122}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000269|PubMed:21249122}. +P77359 DJLC_ECOLI Uncharacterized J domain-containing protein DjlC djlC ybeV b0649 JW0644 ybeV djlC 55,682 positive regulation of ATPase activity [GO:0032781] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; ATPase activator activity [GO:0001671]; positive regulation of ATPase activity [GO:0032781] ATPase activator activity [GO:0001671] GO:0001671; GO:0005887; GO:0032781 +P06149 DLD_ECOLI Quinone-dependent D-lactate dehydrogenase (EC 1.1.5.12) ((R)-lactate:quinone 2-oxidoreductase) (D-lactate dehydrogenase) (D-LDH) (Respiratory D-lactate dehydrogenase) dld b2133 JW2121 dld 64,612 aerobic respiration [GO:0009060]; anaerobic respiration [GO:0009061]; lactate oxidation [GO:0019516]; respiratory electron transport chain [GO:0022904]; transmembrane transport [GO:0055085] extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; D-lactate dehydrogenase (quinone) activity [GO:0102029]; electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [GO:0016901]; quinone binding [GO:0048038]; aerobic respiration [GO:0009060]; anaerobic respiration [GO:0009061]; lactate oxidation [GO:0019516]; respiratory electron transport chain [GO:0022904]; transmembrane transport [GO:0055085] D-lactate dehydrogenase (quinone) activity [GO:0102029]; electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [GO:0016901]; quinone binding [GO:0048038] GO:0005886; GO:0005887; GO:0009055; GO:0009060; GO:0009061; GO:0016901; GO:0019516; GO:0022904; GO:0031234; GO:0048038; GO:0050660; GO:0055085; GO:0071949; GO:0102029 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02092, ECO:0000269|PubMed:1092688, ECO:0000269|PubMed:4575624, ECO:0000269|PubMed:4582730}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_02092, ECO:0000269|PubMed:1092688}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_02092, ECO:0000269|PubMed:1092688}. Note=May bind the membrane through electrostatic rather than hydrophobic forces. {ECO:0000305|PubMed:10944213}. +P31460 DGOR_ECOLI Galactonate operon transcriptional repressor dgoR yidW b4479 JW5627 yidW dgoR 26,080 negative regulation of cellular carbohydrate metabolic process [GO:0010677]; negative regulation of DNA-templated transcription, initiation [GO:2000143] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding [GO:0000984]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; ligand-activated transcription factor activity [GO:0098531]; negative regulation of cellular carbohydrate metabolic process [GO:0010677]; negative regulation of DNA-templated transcription, initiation [GO:2000143] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding [GO:0000984]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; ligand-activated transcription factor activity [GO:0098531] GO:0000984; GO:0000986; GO:0001217; GO:0003677; GO:0010677; GO:0042802; GO:0098531; GO:2000143 +P06710 DPO3X_ECOLI DNA polymerase III subunit tau (EC 2.7.7.7) (DNA polymerase III subunit gamma) dnaX dnaZ dnaZX b0470 JW0459 dnaZ dnaZX dnaX 71,138 DNA-dependent DNA replication [GO:0006261]; DNA replication [GO:0006260] DNA polymerase III, clamp loader complex [GO:0043846]; DNA polymerase III complex [GO:0009360] DNA polymerase III complex [GO:0009360]; DNA polymerase III, clamp loader complex [GO:0043846]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; DNA binding [GO:0003677]; DNA polymerase processivity factor activity [GO:0030337]; DNA-directed DNA polymerase activity [GO:0003887]; identical protein binding [GO:0042802]; nucleoside-triphosphatase activity [GO:0017111]; DNA replication [GO:0006260]; DNA-dependent DNA replication [GO:0006261] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; DNA polymerase processivity factor activity [GO:0030337]; identical protein binding [GO:0042802]; nucleoside-triphosphatase activity [GO:0017111] GO:0003677; GO:0003887; GO:0005524; GO:0006260; GO:0006261; GO:0009360; GO:0016887; GO:0017111; GO:0030337; GO:0042802; GO:0043846 +P75742 DTPD_ECOLI Dipeptide permease D dtpD ybgH b0709 JW0699 ybgH dtpD 54,159 dipeptide transmembrane transport [GO:0035442]; protein transport [GO:0015031] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; tripeptide transmembrane transporter activity [GO:0042937]; dipeptide transmembrane transport [GO:0035442]; protein transport [GO:0015031] dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; tripeptide transmembrane transporter activity [GO:0042937] GO:0005887; GO:0015031; GO:0015333; GO:0035442; GO:0042937; GO:0071916 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76503 FADI_ECOLI 3-ketoacyl-CoA thiolase FadI (EC 2.3.1.16) (ACSs) (Acetyl-CoA acyltransferase) (Acyl-CoA ligase) (Beta-ketothiolase) (Fatty acid oxidation complex subunit beta) fadI yfcY b2342 JW2339 yfcY fadI 46,531 fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation, unsaturated, even number [GO:0033542] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; acetyl-CoA C-acyltransferase activity [GO:0003988]; enoyl-CoA hydratase activity [GO:0004300]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation, unsaturated, even number [GO:0033542] 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; acetyl-CoA C-acyltransferase activity [GO:0003988]; enoyl-CoA hydratase activity [GO:0004300] GO:0003857; GO:0003985; GO:0003988; GO:0004300; GO:0005737; GO:0005829; GO:0006635; GO:0033542 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P30130 FIMD_ECOLI Outer membrane usher protein FimD fimD b4317 JW5780 fimD 96,482 pilus assembly [GO:0009297] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; fimbrial usher porin activity [GO:0015473]; pilus assembly [GO:0009297] fimbrial usher porin activity [GO:0015473] GO:0009279; GO:0009297; GO:0015473; GO:0016021 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. +P32055 FCL_ECOLI GDP-L-fucose synthase (EC 1.1.1.271) (GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase) fcl wcaG yefB b2052 JW2037 wcaG yefB fcl 36,141 'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; colanic acid biosynthetic process [GO:0009242] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; GDP-L-fucose synthase activity [GO:0050577]; isomerase activity [GO:0016853]; NADP+ binding [GO:0070401]; 'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; colanic acid biosynthetic process [GO:0009242] GDP-L-fucose synthase activity [GO:0050577]; isomerase activity [GO:0016853]; NADP+ binding [GO:0070401] GO:0005737; GO:0009242; GO:0016853; GO:0042351; GO:0050577; GO:0070401 SUBCELLULAR LOCATION: Cytoplasm. +P11553 FUCK_ECOLI L-fuculokinase (EC 2.7.1.51) (L-fuculose kinase) fucK b2803 JW2774 fucK 52,259 D-arabinose catabolic process [GO:0019571]; L-fucose catabolic process [GO:0042355]; rhamnose catabolic process [GO:0019301] ATP binding [GO:0005524]; L-fuculokinase activity [GO:0008737]; D-arabinose catabolic process [GO:0019571]; L-fucose catabolic process [GO:0042355]; rhamnose catabolic process [GO:0019301] ATP binding [GO:0005524]; L-fuculokinase activity [GO:0008737] GO:0005524; GO:0008737; GO:0019301; GO:0019571; GO:0042355 +P0A6T1 G6PI_ECOLI Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) pgi b4025 JW3985 pgi 61,530 cellular response to oxidative stress [GO:0034599]; gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glycolytic process [GO:0006096] cytosol [GO:0005829] cytosol [GO:0005829]; glucose-6-phosphate isomerase activity [GO:0004347]; identical protein binding [GO:0042802]; monosaccharide binding [GO:0048029]; cellular response to oxidative stress [GO:0034599]; gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glycolytic process [GO:0006096] glucose-6-phosphate isomerase activity [GO:0004347]; identical protein binding [GO:0042802]; monosaccharide binding [GO:0048029] GO:0004347; GO:0005829; GO:0006094; GO:0006096; GO:0034599; GO:0042802; GO:0048029; GO:0051156 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:4344919}. +P23522 GARL_ECOLI 5-keto-4-deoxy-D-glucarate aldolase (KDGluc aldolase) (KDGlucA) (EC 4.1.2.20) (2-dehydro-3-deoxy-D-glucarate aldolase) (2-keto-3-deoxy-D-glucarate aldolase) (5-dehydro-4-deoxy-D-glucarate aldolase) (Alpha-keto-beta-deoxy-D-glucarate aldolase) garL yhaF b3126 JW3095 yhaF garL 27,384 D-glucarate catabolic process [GO:0042838]; galactarate catabolic process [GO:0046392]; glucarate catabolic process [GO:0019394] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 2-dehydro-3-deoxyglucarate aldolase activity [GO:0008672]; aldehyde-lyase activity [GO:0016832]; carbon-carbon lyase activity [GO:0016830]; magnesium ion binding [GO:0000287]; D-glucarate catabolic process [GO:0042838]; galactarate catabolic process [GO:0046392]; glucarate catabolic process [GO:0019394] 2-dehydro-3-deoxyglucarate aldolase activity [GO:0008672]; aldehyde-lyase activity [GO:0016832]; carbon-carbon lyase activity [GO:0016830]; magnesium ion binding [GO:0000287] GO:0000287; GO:0005737; GO:0008672; GO:0016830; GO:0016832; GO:0019394; GO:0042838; GO:0046392 +P0AC62 GLRX3_ECOLI Glutaredoxin 3 (Grx3) grxC yibM b3610 JW3585 yibM grxC 9,137 cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; deoxyribonucleotide biosynthetic process [GO:0009263] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; electron transfer activity [GO:0009055]; glutathione binding [GO:0043295]; glutathione-disulfide reductase activity [GO:0004362]; protein disulfide oxidoreductase activity [GO:0015035]; cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; deoxyribonucleotide biosynthetic process [GO:0009263] electron transfer activity [GO:0009055]; glutathione binding [GO:0043295]; glutathione-disulfide reductase activity [GO:0004362]; protein disulfide oxidoreductase activity [GO:0015035] GO:0004362; GO:0005737; GO:0005829; GO:0009055; GO:0009263; GO:0015035; GO:0034599; GO:0043295; GO:0045454 +P0AC59 GLRX2_ECOLI Glutaredoxin 2 (Grx2) grxB b1064 JW1051 grxB 24,350 glutathione metabolic process [GO:0006749] cytosol [GO:0005829] cytosol [GO:0005829]; electron transfer activity [GO:0009055]; glutathione disulfide oxidoreductase activity [GO:0015038]; glutathione oxidoreductase activity [GO:0097573]; glutathione metabolic process [GO:0006749] electron transfer activity [GO:0009055]; glutathione disulfide oxidoreductase activity [GO:0015038]; glutathione oxidoreductase activity [GO:0097573] GO:0005829; GO:0006749; GO:0009055; GO:0015038; GO:0097573 +P34749 HOFQ_ECOLI DNA utilization protein HofQ hofQ hopQ b3391 JW3354 hopQ hofQ 44,716 carbon utilization [GO:0015976]; DNA catabolic process [GO:0006308]; protein secretion [GO:0009306] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; DNA binding [GO:0003677]; carbon utilization [GO:0015976]; DNA catabolic process [GO:0006308]; protein secretion [GO:0009306] DNA binding [GO:0003677] GO:0003677; GO:0006308; GO:0009279; GO:0009306; GO:0015976 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}. +P39344 IDNT_ECOLI Gnt-II system L-idonate transporter (L-Ido transporter) (5-keto-D-gluconate transporter) idnT gntW yjgT b4265 JW4222 gntW yjgT idnT 46,041 carbohydrate transport [GO:0008643]; D-gluconate metabolic process [GO:0019521]; gluconate transmembrane transport [GO:0035429]; L-idonate catabolic process [GO:0046183]; L-idonate transmembrane transport [GO:0015726] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; gluconate transmembrane transporter activity [GO:0015128]; L-idonate transmembrane transporter activity [GO:0015568]; carbohydrate transport [GO:0008643]; D-gluconate metabolic process [GO:0019521]; gluconate transmembrane transport [GO:0035429]; L-idonate catabolic process [GO:0046183]; L-idonate transmembrane transport [GO:0015726] gluconate transmembrane transporter activity [GO:0015128]; L-idonate transmembrane transporter activity [GO:0015568] GO:0005886; GO:0005887; GO:0008643; GO:0015128; GO:0015568; GO:0015726; GO:0019521; GO:0035429; GO:0046183 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P05052 APPY_ECOLI HTH-type transcriptional regulator AppY (M5 polypeptide) appY b0564 JW0553 appY 28,763 cellular response to phosphate starvation [GO:0016036]; positive regulation of transcription, DNA-templated [GO:0045893]; response to X-ray [GO:0010165] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; cellular response to phosphate starvation [GO:0016036]; positive regulation of transcription, DNA-templated [GO:0045893]; response to X-ray [GO:0010165] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0010165; GO:0016036; GO:0043565; GO:0045893 +P77570 ANMK_ECOLI Anhydro-N-acetylmuramic acid kinase (EC 2.7.1.170) (AnhMurNAc kinase) anmK ydhH b1640 JW1632 ydhH anmK 39,496 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process [GO:0097175]; amino sugar metabolic process [GO:0006040]; carbohydrate metabolic process [GO:0005975]; peptidoglycan turnover [GO:0009254] ATP binding [GO:0005524]; kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process [GO:0097175]; amino sugar metabolic process [GO:0006040]; carbohydrate metabolic process [GO:0005975]; peptidoglycan turnover [GO:0009254] ATP binding [GO:0005524]; kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773] GO:0005524; GO:0005975; GO:0006040; GO:0009254; GO:0016301; GO:0016773; GO:0097175 +P11446 ARGC_ECOLI N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) (EC 1.2.1.38) (N-acetyl-glutamate semialdehyde dehydrogenase) (NAGSA dehydrogenase) argC b3958 JW3930 argC 35,952 arginine biosynthetic process [GO:0006526] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; N-acetyl-gamma-glutamyl-phosphate reductase activity [GO:0003942]; NAD binding [GO:0051287]; protein dimerization activity [GO:0046983]; arginine biosynthetic process [GO:0006526] N-acetyl-gamma-glutamyl-phosphate reductase activity [GO:0003942]; NAD binding [GO:0051287]; protein dimerization activity [GO:0046983] GO:0003942; GO:0005737; GO:0006526; GO:0046983; GO:0051287 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00150}. +P00963 ASNA_ECOLI Aspartate--ammonia ligase (EC 6.3.1.1) (Asparagine synthetase A) asnA b3744 JW3722 asnA 36,651 asparagine biosynthetic process [GO:0006529]; cellular response to DNA damage stimulus [GO:0006974]; L-asparagine biosynthetic process [GO:0070981] cytosol [GO:0005829] cytosol [GO:0005829]; aspartate-ammonia ligase activity [GO:0004071]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; asparagine biosynthetic process [GO:0006529]; cellular response to DNA damage stimulus [GO:0006974]; L-asparagine biosynthetic process [GO:0070981] aspartate-ammonia ligase activity [GO:0004071]; ATP binding [GO:0005524]; identical protein binding [GO:0042802] GO:0004071; GO:0005524; GO:0005829; GO:0006529; GO:0006974; GO:0042802; GO:0070981 SUBCELLULAR LOCATION: Cytoplasm. +P76216 ASTB_ECOLI N-succinylarginine dihydrolase (EC 3.5.3.23) astB ydjT b1745 JW1734 ydjT astB 49,299 arginine catabolic process [GO:0006527]; arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to succinate [GO:0019545] N-succinylarginine dihydrolase activity [GO:0009015]; arginine catabolic process [GO:0006527]; arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to succinate [GO:0019545] N-succinylarginine dihydrolase activity [GO:0009015] GO:0006527; GO:0009015; GO:0019544; GO:0019545 +P0ABQ0 COABC_ECOLI Coenzyme A biosynthesis bifunctional protein CoaBC (DNA/pantothenate metabolism flavoprotein) (Phosphopantothenoylcysteine synthetase/decarboxylase) (PPCS-PPCDC) [Includes: Phosphopantothenoylcysteine decarboxylase (PPC decarboxylase) (PPC-DC) (EC 4.1.1.36) (CoaC); Phosphopantothenate--cysteine ligase (EC 6.3.2.5) (CoaB) (Phosphopantothenoylcysteine synthetase) (PPC synthetase) (PPC-S)] coaBC dfp b3639 JW5642 dfp coaBC 43,438 coenzyme A biosynthetic process [GO:0015937]; pantothenate catabolic process [GO:0015941] cytosol [GO:0005829]; phosphopantothenoylcysteine decarboxylase complex [GO:0071513] cytosol [GO:0005829]; phosphopantothenoylcysteine decarboxylase complex [GO:0071513]; FMN binding [GO:0010181]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphopantothenate--cysteine ligase activity [GO:0004632]; phosphopantothenoylcysteine decarboxylase activity [GO:0004633]; coenzyme A biosynthetic process [GO:0015937]; pantothenate catabolic process [GO:0015941] FMN binding [GO:0010181]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphopantothenate--cysteine ligase activity [GO:0004632]; phosphopantothenoylcysteine decarboxylase activity [GO:0004633] GO:0004632; GO:0004633; GO:0005829; GO:0010181; GO:0015937; GO:0015941; GO:0042802; GO:0046872; GO:0071513 +P0ABB4 ATPB_ECOLI ATP synthase subunit beta (EC 7.1.2.2) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta) atpD papB uncD b3732 JW3710 papB uncD atpD 50,325 membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261] membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; ATP binding [GO:0005524]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961] ATP binding [GO:0005524]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933] GO:0005524; GO:0005886; GO:0016020; GO:0045261; GO:0046933; GO:0046961 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. +P68699 ATPL_ECOLI ATP synthase subunit c (ATP synthase F(0) sector subunit c) (Dicyclohexylcarbodiimide-binding protein) (F-type ATPase subunit c) (F-ATPase subunit c) (Lipid-binding protein) atpE papH uncE b3737 JW3715 papH uncE atpE 8,256 ATP synthesis coupled proton transport [GO:0015986] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]; lipid binding [GO:0008289]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP synthesis coupled proton transport [GO:0015986] lipid binding [GO:0008289]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933] GO:0005886; GO:0008289; GO:0015986; GO:0016021; GO:0045263; GO:0046933; GO:0046961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P39396 BTST_ECOLI Pyruvate/proton symporter BtsT (Brenztraubensaure transporter) (Pyruvate/H(+) symporter) btsT yjiY b4354 JW5791 yjiY btsT 77,324 cellular response to DNA damage stimulus [GO:0006974]; cellular response to nutrient levels [GO:0031669]; cellular response to starvation [GO:0009267]; plasma membrane pyruvate transport [GO:0006849] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; pyruvate secondary active transmembrane transporter activity [GO:0005477]; symporter activity [GO:0015293]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to nutrient levels [GO:0031669]; cellular response to starvation [GO:0009267]; plasma membrane pyruvate transport [GO:0006849] pyruvate secondary active transmembrane transporter activity [GO:0005477]; symporter activity [GO:0015293] GO:0005477; GO:0005886; GO:0005887; GO:0006849; GO:0006974; GO:0009267; GO:0015293; GO:0031669 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:22685278, ECO:0000269|PubMed:29061664}; Multi-pass membrane protein {ECO:0000305|PubMed:29061664}. +P0A937 BAME_ECOLI Outer membrane protein assembly factor BamE bamE smpA b2617 JW2598 smpA bamE 12,302 Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; protein insertion into membrane [GO:0051205]; response to antibiotic [GO:0046677] Bam protein complex [GO:1990063] Bam protein complex [GO:1990063]; identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; protein insertion into membrane [GO:0051205]; response to antibiotic [GO:0046677] identical protein binding [GO:0042802]; protein-macromolecule adaptor activity [GO:0030674] GO:0030674; GO:0042802; GO:0043165; GO:0046677; GO:0051205; GO:1990063 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_00925, ECO:0000269|PubMed:17404237, ECO:0000269|PubMed:26900875, ECO:0000269|PubMed:26901871}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_00925, ECO:0000269|PubMed:17404237, ECO:0000269|PubMed:27686148}. +P0A903 BAMC_ECOLI Outer membrane protein assembly factor BamC bamC dapX nlpB b2477 JW2462 dapX nlpB bamC 36,842 Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; protein insertion into membrane [GO:0051205] Bam protein complex [GO:1990063]; cell surface [GO:0009986] Bam protein complex [GO:1990063]; cell surface [GO:0009986]; identical protein binding [GO:0042802]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; protein insertion into membrane [GO:0051205] identical protein binding [GO:0042802] GO:0009986; GO:0042802; GO:0043165; GO:0051205; GO:1990063 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_00924, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:26900875, ECO:0000269|PubMed:26901871}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_00924, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:27686148}. +P75726 CILA_ECOLI Citrate lyase alpha chain (Citrase alpha chain) (EC 4.1.3.6) (Citrate (pro-3S)-lyase alpha chain) (Citrate CoA-transferase subunit) (EC 2.8.3.10) citF ybdV b0615 JW5087 ybdV citF 55,173 acetyl-CoA metabolic process [GO:0006084] citrate lyase complex [GO:0009346] citrate lyase complex [GO:0009346]; citrate (pro-3S)-lyase activity [GO:0008815]; citrate CoA-transferase activity [GO:0008814]; acetyl-CoA metabolic process [GO:0006084] citrate (pro-3S)-lyase activity [GO:0008815]; citrate CoA-transferase activity [GO:0008814] GO:0006084; GO:0008814; GO:0008815; GO:0009346 SUBCELLULAR LOCATION: Cytoplasm. +P0A6B4 ALR1_ECOLI Alanine racemase, biosynthetic (EC 5.1.1.1) alr b4053 JW4013 alr 39,153 cell wall organization [GO:0071555]; D-alanine biosynthetic process [GO:0030632]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] cytosol [GO:0005829] cytosol [GO:0005829]; alanine racemase activity [GO:0008784]; pyridoxal phosphate binding [GO:0030170]; cell wall organization [GO:0071555]; D-alanine biosynthetic process [GO:0030632]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] alanine racemase activity [GO:0008784]; pyridoxal phosphate binding [GO:0030170] GO:0005829; GO:0008360; GO:0008784; GO:0009252; GO:0030170; GO:0030632; GO:0071555 +P0A6I6 COAD_ECOLI Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT) coaD kdtB yicA b3634 JW3609 kdtB yicA coaD 17,837 coenzyme A biosynthetic process [GO:0015937] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; pantetheine-phosphate adenylyltransferase activity [GO:0004595]; coenzyme A biosynthetic process [GO:0015937] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; pantetheine-phosphate adenylyltransferase activity [GO:0004595] GO:0004595; GO:0005524; GO:0005737; GO:0015937; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00151}. +P0AB98 ATP6_ECOLI ATP synthase subunit a (ATP synthase F0 sector subunit a) (F-ATPase subunit 6) atpB papD uncB b3738 JW3716 papD uncB atpB 30,303 plasma membrane ATP synthesis coupled proton transport [GO:0042777] integral component of plasma membrane [GO:0005887]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263] integral component of plasma membrane [GO:0005887]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; plasma membrane ATP synthesis coupled proton transport [GO:0042777] proton-transporting ATP synthase activity, rotational mechanism [GO:0046933] GO:0005887; GO:0042777; GO:0045263; GO:0046933 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01393, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01393, ECO:0000269|PubMed:15919996}. +P12998 BIOF_ECOLI 8-amino-7-oxononanoate synthase (AONS) (EC 2.3.1.47) (7-keto-8-amino-pelargonic acid synthase) (7-KAP synthase) (KAPA synthase) (8-amino-7-ketopelargonate synthase) bioF b0776 JW0759 bioF 41,594 biotin biosynthetic process [GO:0009102] 8-amino-7-oxononanoate synthase activity [GO:0008710]; pyridoxal phosphate binding [GO:0030170]; biotin biosynthetic process [GO:0009102] 8-amino-7-oxononanoate synthase activity [GO:0008710]; pyridoxal phosphate binding [GO:0030170] GO:0008710; GO:0009102; GO:0030170 +P0AAY1 BSSR_ECOLI Biofilm regulator BssR bssR yliH b0836 JW0820 yliH bssR 14,536 regulation of gene expression [GO:0010468]; regulation of single-species biofilm formation [GO:1900190] regulation of gene expression [GO:0010468]; regulation of single-species biofilm formation [GO:1900190] GO:0010468; GO:1900190 +Q46896 CAS1_ECOLI CRISPR-associated endonuclease Cas1 (EC 3.1.-.-) ygbT cas1 b2755 JW2725 cas1 ygbT 33,194 cellular response to DNA damage stimulus [GO:0006974]; defense response to virus [GO:0051607]; DNA repair [GO:0006281]; maintenance of CRISPR repeat elements [GO:0043571] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 5'-flap endonuclease activity [GO:0017108]; crossover junction endodeoxyribonuclease activity [GO:0008821]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; cellular response to DNA damage stimulus [GO:0006974]; defense response to virus [GO:0051607]; DNA repair [GO:0006281]; maintenance of CRISPR repeat elements [GO:0043571] 5'-flap endonuclease activity [GO:0017108]; crossover junction endodeoxyribonuclease activity [GO:0008821]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] GO:0003677; GO:0005737; GO:0006281; GO:0006974; GO:0008821; GO:0017108; GO:0042802; GO:0043571; GO:0046872; GO:0051607 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21219465}. Note=In 15% of cell localizes to discrete nucleoid foci (probable DNA damage sites) upon treatment with mitomycin C (MMC) for 2 hours (PubMed:21219465). {ECO:0000269|PubMed:21219465}. +P0A6G5 CITX_ECOLI Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (EC 2.7.7.61) (Apo-ACP nucleodityltransferase) (Holo-ACP synthase) (Holo-citrate lyase synthase) citX ybdU b0614 JW0606 ybdU citX 20,270 prosthetic group biosynthetic process [GO:0051191]; protein-phosphoribosyl dephospho-coenzyme A linkage [GO:0018247] holo-citrate lyase synthase activity [GO:0050519]; prosthetic group biosynthetic process [GO:0051191]; protein-phosphoribosyl dephospho-coenzyme A linkage [GO:0018247] holo-citrate lyase synthase activity [GO:0050519] GO:0018247; GO:0050519; GO:0051191 +P0A9G6 ACEA_ECOLI Isocitrate lyase (ICL) (EC 4.1.3.1) (Isocitrase) (Isocitratase) aceA icl b4015 JW3975 icl aceA 47,522 glyoxylate cycle [GO:0006097]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829] cytosol [GO:0005829]; cation binding [GO:0043169]; isocitrate lyase activity [GO:0004451]; metal ion binding [GO:0046872]; glyoxylate cycle [GO:0006097]; tricarboxylic acid cycle [GO:0006099] cation binding [GO:0043169]; isocitrate lyase activity [GO:0004451]; metal ion binding [GO:0046872] GO:0004451; GO:0005829; GO:0006097; GO:0006099; GO:0043169; GO:0046872 +P68767 AMPA_ECOLI Cytosol aminopeptidase (EC 3.4.11.1) (Aminopeptidase A/I) (Leucine aminopeptidase) (LAP) (EC 3.4.11.10) (Leucyl aminopeptidase) pepA carP xerB b4260 JW4217 carP xerB pepA 54,880 peptide catabolic process [GO:0043171]; plasmid maintenance [GO:0006276]; plasmid recombination [GO:0042150]; transcription, DNA-templated [GO:0006351] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; aminopeptidase activity [GO:0004177]; DNA binding [GO:0003677]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; transcription antitermination factor activity, DNA binding [GO:0001073]; peptide catabolic process [GO:0043171]; plasmid maintenance [GO:0006276]; plasmid recombination [GO:0042150]; transcription, DNA-templated [GO:0006351] aminopeptidase activity [GO:0004177]; DNA binding [GO:0003677]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; transcription antitermination factor activity, DNA binding [GO:0001073] GO:0001073; GO:0003677; GO:0004177; GO:0005737; GO:0006276; GO:0006351; GO:0030145; GO:0042150; GO:0043171; GO:0070006 +P33234 ADIY_ECOLI HTH-type transcriptional regulator AdiY adiY b4116 JW4077 adiY 29,007 positive regulation of transcription, DNA-templated [GO:0045893] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; positive regulation of transcription, DNA-templated [GO:0045893] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0043565; GO:0045893 +P05194 AROD_ECOLI 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10) (Type I DHQase) (Type I dehydroquinase) (DHQ1) aroD b1693 JW1683 aroD 27,467 3,4-dihydroxybenzoate biosynthetic process [GO:0046279]; aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] cytosol [GO:0005829] cytosol [GO:0005829]; 3-dehydroquinate dehydratase activity [GO:0003855]; 3,4-dihydroxybenzoate biosynthetic process [GO:0046279]; aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] 3-dehydroquinate dehydratase activity [GO:0003855] GO:0003855; GO:0005829; GO:0008652; GO:0009073; GO:0009423; GO:0046279 +P0AC38 ASPA_ECOLI Aspartate ammonia-lyase (Aspartase) (EC 4.3.1.1) aspA b4139 JW4099 aspA 52,356 aspartate metabolic process [GO:0006531]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; aspartate ammonia-lyase activity [GO:0008797]; aspartate metabolic process [GO:0006531]; tricarboxylic acid cycle [GO:0006099] aspartate ammonia-lyase activity [GO:0008797] GO:0005829; GO:0006099; GO:0006531; GO:0008797; GO:0016020 +P0AB93 ARSB_ECOLI Arsenical pump membrane protein (Arsenic efflux pump protein) arsB arsF b3502 JW3469 arsF arsB 45,497 antimonite transport [GO:0015699]; arsenite transport [GO:0015700]; response to arsenic-containing substance [GO:0046685] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; antimonite secondary active transmembrane transporter activity [GO:0042960]; arsenite secondary active transmembrane transporter activity [GO:0008490]; antimonite transport [GO:0015699]; arsenite transport [GO:0015700]; response to arsenic-containing substance [GO:0046685] antimonite secondary active transmembrane transporter activity [GO:0042960]; arsenite secondary active transmembrane transporter activity [GO:0008490] GO:0005886; GO:0005887; GO:0008490; GO:0015699; GO:0015700; GO:0016021; GO:0042960; GO:0046685 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76472 ARND_ECOLI Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD (EC 3.5.1.n3) arnD pmrJ yfbH b2256 JW2250 pmrJ yfbH arnD 33,112 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process [GO:0036108]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; response to antibiotic [GO:0046677]; response to iron(III) ion [GO:0010041] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process [GO:0036108]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; response to antibiotic [GO:0046677]; response to iron(III) ion [GO:0010041] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811] GO:0009103; GO:0009245; GO:0010041; GO:0016811; GO:0036108; GO:0046677 +P0ABD3 BFR_ECOLI Bacterioferritin (BFR) (EC 1.16.3.1) (Cytochrome b-1) (Cytochrome b-557) bfr b3336 JW3298 bfr 18,495 intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; ferric iron binding [GO:0008199]; ferroxidase activity [GO:0004322]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826] ferric iron binding [GO:0008199]; ferroxidase activity [GO:0004322]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491] GO:0004322; GO:0005506; GO:0005829; GO:0006826; GO:0006880; GO:0008199; GO:0016020; GO:0016491; GO:0020037; GO:0042802 +P0ABL8 CCMB_ECOLI Heme exporter protein B (Cytochrome c-type biogenesis protein CcmB) ccmB yejV b2200 JW2188 yejV ccmB 23,619 cytochrome complex assembly [GO:0017004] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATPase activity [GO:0016887]; heme transmembrane transporter activity [GO:0015232]; cytochrome complex assembly [GO:0017004] ATPase activity [GO:0016887]; heme transmembrane transporter activity [GO:0015232] GO:0005886; GO:0005887; GO:0015232; GO:0016887; GO:0017004; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P05100 3MG1_ECOLI DNA-3-methyladenine glycosylase 1 (EC 3.2.2.20) (3-methyladenine-DNA glycosylase I, constitutive) (TAG I) (DNA-3-methyladenine glycosidase I) (DNA-3-methyladenine glycosylase I) tag b3549 JW3518 tag 21,100 base-excision repair [GO:0006284]; DNA dealkylation involved in DNA repair [GO:0006307] DNA-3-methyladenine glycosylase activity [GO:0008725]; metal ion binding [GO:0046872]; base-excision repair [GO:0006284]; DNA dealkylation involved in DNA repair [GO:0006307] DNA-3-methyladenine glycosylase activity [GO:0008725]; metal ion binding [GO:0046872] GO:0006284; GO:0006307; GO:0008725; GO:0046872 +P23325 ARPA_ECOLI Ankyrin repeat protein A (Ankyrin-like regulatory protein) arpA arp yjaC b4017 JW3977 arp yjaC arpA 82,598 +P76205 ARPB_ECOLI Putative ankyrin repeat protein B arpB b4494 JW5278/JW1710 b1720/b1721 arpB 18,234 +P0ABC0 ATPZ_ECOLI ATP synthase protein I atpI uncI b3739 JW5611 uncI atpI 13,632 ion transport [GO:0006811] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]; ion transport [GO:0006811] GO:0005886; GO:0006811; GO:0016021; GO:0045263 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P06610 BTUE_ECOLI Thioredoxin/glutathione peroxidase BtuE (EC 1.11.1.24) (EC 1.11.1.9) btuE b1710 JW1700 btuE 20,470 response to hydroperoxide [GO:0033194] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; glutathione peroxidase activity [GO:0004602]; thioredoxin peroxidase activity [GO:0008379]; response to hydroperoxide [GO:0033194] glutathione peroxidase activity [GO:0004602]; thioredoxin peroxidase activity [GO:0008379] GO:0004602; GO:0008379; GO:0033194; GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000305|PubMed:3528129}. Note=Appears to have a periplasmic location. It has the mean hydropathy of a soluble protein but lacks an obvious signal sequence. {ECO:0000305|PubMed:3528129}. +P11989 BGLG_ECOLI Cryptic beta-glucoside bgl operon antiterminator bglG bglC b3723 JW3701 bglC bglG 32,097 positive regulation of transcription, DNA-templated [GO:0045893] RNA binding [GO:0003723]; positive regulation of transcription, DNA-templated [GO:0045893] RNA binding [GO:0003723] GO:0003723; GO:0045893 +P37657 BCSE_ECOLI Cyclic di-GMP binding protein BcsE (Cellulose biosynthesis protein BcsE) bcsE yhjS b3536 JW3504 yhjS bcsE 59,428 cellulose biosynthetic process [GO:0030244] cyclic-di-GMP binding [GO:0035438]; cellulose biosynthetic process [GO:0030244] cyclic-di-GMP binding [GO:0035438] GO:0030244; GO:0035438 +P0ABG1 CDSA_ECOLI Phosphatidate cytidylyltransferase (EC 2.7.7.41) (CDP-DAG synthase) (CDP-DG synthase) (CDP-diacylglycerol synthase) (CDS) (CDP-diglyceride pyrophosphorylase) (CDP-diglyceride synthase) (CTP:phosphatidate cytidylyltransferase) cdsA cds b0175 JW5810 cds cdsA 31,454 CDP-diacylglycerol biosynthetic process [GO:0016024] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; phosphatidate cytidylyltransferase activity [GO:0004605]; CDP-diacylglycerol biosynthetic process [GO:0016024] phosphatidate cytidylyltransferase activity [GO:0004605] GO:0004605; GO:0005886; GO:0016021; GO:0016024 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77808 CINAL_ECOLI NMN amidohydrolase-like protein YfaY yfaY b2249 JW2243 yfaY 44,226 +P77395 CNOX_ECOLI Chaperedoxin (Heat shock protein CnoX) (Trxsc) cnoX ybbN b0492 JW5067 ybbN cnoX 31,791 cellular response to oxidative stress [GO:0034599]; chaperone-mediated protein folding [GO:0061077]; maintenance of unfolded protein [GO:0036506]; protein refolding [GO:0042026] cytosol [GO:0005829] cytosol [GO:0005829]; unfolded protein binding [GO:0051082]; cellular response to oxidative stress [GO:0034599]; chaperone-mediated protein folding [GO:0061077]; maintenance of unfolded protein [GO:0036506]; protein refolding [GO:0042026] unfolded protein binding [GO:0051082] GO:0005829; GO:0034599; GO:0036506; GO:0042026; GO:0051082; GO:0061077 +P0AEG8 DSRB_ECOLI Protein DsrB dsrB b1952 JW1936 dsrB 6,946 +P0A9X9 CSPA_ECOLI Cold shock protein CspA (CSP-A) (7.4 kDa cold shock protein) (CS7.4) cspA cspS b3556 JW3525 cspS cspA 7,403 negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468]; response to cold [GO:0009409]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; transcription antitermination factor activity, RNA binding [GO:0001072]; negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468]; response to cold [GO:0009409]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; transcription antitermination factor activity, RNA binding [GO:0001072] GO:0001072; GO:0003676; GO:0003677; GO:0003697; GO:0003723; GO:0003727; GO:0005829; GO:0006351; GO:0009409; GO:0010468; GO:0060567 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:2404279}. +P75952 COMR_ECOLI HTH-type transcriptional repressor ComR (Copper outer membrane regulator) comR ycfQ b1111 JW5159 ycfQ comR 23,362 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; response to copper ion [GO:0046688] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; response to copper ion [GO:0046688] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003677; GO:0003700; GO:0006355; GO:0045892; GO:0046688 +P0ACN7 CYTR_ECOLI HTH-type transcriptional repressor CytR cytR b3934 JW3905 cytR 37,820 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0005829; GO:0006355; GO:0045892 +P22255 CYSQ_ECOLI 3'(2'),5'-bisphosphate nucleotidase CysQ (EC 3.1.3.7) (3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase) (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (DPNPase) cysQ amtA b4214 JW4172 amtA cysQ 27,176 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; inositol phosphate dephosphorylation [GO:0046855]; phosphatidylinositol phosphorylation [GO:0046854]; sulfate assimilation [GO:0000103] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; 3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441]; magnesium ion binding [GO:0000287]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; inositol phosphate dephosphorylation [GO:0046855]; phosphatidylinositol phosphorylation [GO:0046854]; sulfate assimilation [GO:0000103] 3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441]; magnesium ion binding [GO:0000287] GO:0000103; GO:0000287; GO:0005886; GO:0008441; GO:0046854; GO:0046855; GO:0050427 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02095, ECO:0000269|PubMed:15911532}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_02095, ECO:0000305}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_02095, ECO:0000305}. +P36649 CUEO_ECOLI Blue copper oxidase CueO (Copper efflux oxidase) cueO yacK b0123 JW0119 yacK cueO 56,556 detoxification of copper ion [GO:0010273]; response to copper ion [GO:0046688] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; copper ion binding [GO:0005507]; ferroxidase activity [GO:0004322]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [GO:0016682]; oxidoreductase activity, acting on metal ions [GO:0016722]; oxidoreductase activity, acting on metal ions, oxygen as acceptor [GO:0016724]; detoxification of copper ion [GO:0010273]; response to copper ion [GO:0046688] copper ion binding [GO:0005507]; ferroxidase activity [GO:0004322]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [GO:0016682]; oxidoreductase activity, acting on metal ions [GO:0016722]; oxidoreductase activity, acting on metal ions, oxygen as acceptor [GO:0016724] GO:0004322; GO:0005507; GO:0010273; GO:0016491; GO:0016682; GO:0016722; GO:0016724; GO:0030288; GO:0042597; GO:0046688 SUBCELLULAR LOCATION: Periplasm. Note=It is exported via the Tat pathway. +P37306 ARCC_ECOLI Carbamate kinase (EC 2.7.2.2) arcC ybcF b0521 JW0510 ybcF arcC 31,644 arginine deiminase pathway [GO:0019546]; carbamoyl phosphate catabolic process [GO:0035975] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; carbamate kinase activity [GO:0008804]; arginine deiminase pathway [GO:0019546]; carbamoyl phosphate catabolic process [GO:0035975] ATP binding [GO:0005524]; carbamate kinase activity [GO:0008804] GO:0005524; GO:0005829; GO:0008804; GO:0019546; GO:0035975 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P15993 AROP_ECOLI Aromatic amino acid transport protein AroP (General aromatic amino acid permease) aroP b0112 JW0108 aroP 49,690 phenylalanine transport [GO:0015823]; tryptophan transport [GO:0015827]; tyrosine transport [GO:0015828] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; L-phenylalanine transmembrane transporter activity [GO:0015192]; L-tryptophan transmembrane transporter activity [GO:0015196]; L-tyrosine transmembrane transporter activity [GO:0005302]; phenylalanine transport [GO:0015823]; tryptophan transport [GO:0015827]; tyrosine transport [GO:0015828] L-phenylalanine transmembrane transporter activity [GO:0015192]; L-tryptophan transmembrane transporter activity [GO:0015196]; L-tyrosine transmembrane transporter activity [GO:0005302] GO:0005302; GO:0005886; GO:0005887; GO:0015192; GO:0015196; GO:0015823; GO:0015827; GO:0015828 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AE37 ASTA_ECOLI Arginine N-succinyltransferase (AST) (EC 2.3.1.109) (AOST) astA ydjV b1747 JW1736 ydjV astA 38,456 arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to succinate [GO:0019545] arginine N-succinyltransferase activity [GO:0008791]; arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to succinate [GO:0019545] arginine N-succinyltransferase activity [GO:0008791] GO:0008791; GO:0019544; GO:0019545 +P77581 ASTC_ECOLI Succinylornithine transaminase (SOAT) (EC 2.6.1.81) (Carbon starvation protein C) (Succinylornithine aminotransferase) astC argM cstC ydjW b1748 JW1737 argM cstC ydjW astC 43,665 arginine biosynthetic process via ornithine [GO:0042450]; arginine catabolic process [GO:0006527]; arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to succinate [GO:0019545]; ornithine catabolic process [GO:0006593] identical protein binding [GO:0042802]; N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity [GO:0003992]; pyridoxal phosphate binding [GO:0030170]; succinylornithine transaminase activity [GO:0043825]; arginine biosynthetic process via ornithine [GO:0042450]; arginine catabolic process [GO:0006527]; arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to succinate [GO:0019545]; ornithine catabolic process [GO:0006593] identical protein binding [GO:0042802]; N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity [GO:0003992]; pyridoxal phosphate binding [GO:0030170]; succinylornithine transaminase activity [GO:0043825] GO:0003992; GO:0006527; GO:0006593; GO:0019544; GO:0019545; GO:0030170; GO:0042450; GO:0042802; GO:0043825 +P28307 CSGA_ECOLI Major curlin subunit csgA b1042 JW1025 csgA 15,049 amyloid fibril formation [GO:1990000]; cell adhesion [GO:0007155]; single-species biofilm formation [GO:0044010] pilus [GO:0009289] pilus [GO:0009289]; identical protein binding [GO:0042802]; amyloid fibril formation [GO:1990000]; cell adhesion [GO:0007155]; single-species biofilm formation [GO:0044010] identical protein binding [GO:0042802] GO:0007155; GO:0009289; GO:0042802; GO:0044010; GO:1990000 SUBCELLULAR LOCATION: Fimbrium. Note=Part of the curli surface structure. +P0ABK7 CSGB_ECOLI Minor curlin subunit csgB b1041 JW1024 csgB 15,882 amyloid fibril formation [GO:1990000]; cell adhesion [GO:0007155]; single-species biofilm formation [GO:0044010] cell outer membrane [GO:0009279]; pilus [GO:0009289] cell outer membrane [GO:0009279]; pilus [GO:0009289]; identical protein binding [GO:0042802]; amyloid fibril formation [GO:1990000]; cell adhesion [GO:0007155]; single-species biofilm formation [GO:0044010] identical protein binding [GO:0042802] GO:0007155; GO:0009279; GO:0009289; GO:0042802; GO:0044010; GO:1990000 SUBCELLULAR LOCATION: Fimbrium. Note=Part of the curli surface structure. +P52107 CSGC_ECOLI Curli assembly protein CsgC csgC b1043 JW1026 csgC 11,967 periplasmic space [GO:0042597] periplasmic space [GO:0042597] GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000250}. +P52106 CSGD_ECOLI CsgBAC operon transcriptional regulatory protein csgD b1040 JW1023 csgD 24,935 positive regulation of DNA-templated transcription, initiation [GO:2000144]; regulation of single-species biofilm formation [GO:1900190] plasma membrane [GO:0005886]; protein-DNA complex [GO:0032993] plasma membrane [GO:0005886]; protein-DNA complex [GO:0032993]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; regulation of single-species biofilm formation [GO:1900190] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0000986; GO:0001216; GO:0001217; GO:0005886; GO:0032993; GO:0042802; GO:1900190; GO:2000144 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:16513732}; Peripheral membrane protein {ECO:0000305|PubMed:16513732}. Note=In experiments done with low-level constitutively expressed protein. +P0AEA2 CSGG_ECOLI Curli production assembly/transport component CsgG csgG b1037 JW1020 csgG 30,557 biological adhesion [GO:0022610]; protein transmembrane transport [GO:0071806]; single-species biofilm formation [GO:0044010] cell outer membrane [GO:0009279]; intrinsic component of periplasmic side of cell outer membrane [GO:0031246]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] cell outer membrane [GO:0009279]; intrinsic component of periplasmic side of cell outer membrane [GO:0031246]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; biological adhesion [GO:0022610]; protein transmembrane transport [GO:0071806]; single-species biofilm formation [GO:0044010] identical protein binding [GO:0042802] GO:0005886; GO:0009279; GO:0022610; GO:0030288; GO:0031246; GO:0042802; GO:0044010; GO:0071806 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P0ACP1 CRA_ECOLI Catabolite repressor/activator (Fructose repressor) cra fruC fruR shl b0080 JW0078 fruC fruR shl cra 37,999 regulation of DNA-templated transcription, initiation [GO:2000142]; regulation of transcription, DNA-templated [GO:0006355]; response to fructose [GO:0009750] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of DNA-templated transcription, initiation [GO:2000142]; regulation of transcription, DNA-templated [GO:0006355]; response to fructose [GO:0009750] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0000986; GO:0003700; GO:0006355; GO:0009750; GO:0042802; GO:2000142 +P0A972 CSPE_ECOLI Cold shock-like protein CspE (CSP-E) cspE gicA msmC b0623 JW0618 gicA msmC cspE 7,463 negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468] cytosol [GO:0005829] cytosol [GO:0005829]; nucleic acid binding [GO:0003676]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; transcription antitermination factor activity, RNA binding [GO:0001072]; negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468] nucleic acid binding [GO:0003676]; poly(A) binding [GO:0008143]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; transcription antitermination factor activity, RNA binding [GO:0001072] GO:0001072; GO:0003676; GO:0003697; GO:0003723; GO:0005829; GO:0008143; GO:0010468; GO:0060567 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P0A976 CSPF_ECOLI Cold shock-like protein CspF (CSP-F) cspF b1558 JW1550 cspF 7,563 negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; transcription antitermination factor activity, RNA binding [GO:0001072]; negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468] DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; transcription antitermination factor activity, RNA binding [GO:0001072] GO:0001072; GO:0003676; GO:0003677; GO:0003723; GO:0005829; GO:0010468; GO:0060567 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +Q46925 CSDA_ECOLI Cysteine desulfurase CsdA (EC 2.8.1.7) (Cysteine sulfinate desulfinase) (CSD) (EC 4.4.1.-) (Selenocysteine lyase) (EC 4.4.1.16) csdA ygdJ b2810 JW2781 ygdJ csdA 43,234 iron-sulfur cluster assembly [GO:0016226]; sulfur amino acid metabolic process [GO:0000096] cysteine desulfurase activity [GO:0031071]; pyridoxal phosphate binding [GO:0030170]; selenocysteine lyase activity [GO:0009000]; sulfurtransferase activity [GO:0016783]; iron-sulfur cluster assembly [GO:0016226]; sulfur amino acid metabolic process [GO:0000096] cysteine desulfurase activity [GO:0031071]; pyridoxal phosphate binding [GO:0030170]; selenocysteine lyase activity [GO:0009000]; sulfurtransferase activity [GO:0016783] GO:0000096; GO:0009000; GO:0016226; GO:0016783; GO:0030170; GO:0031071 +P0ABC9 BETT_ECOLI High-affinity choline transport protein betT b0314 JW0306 betT 75,842 cellular response to DNA damage stimulus [GO:0006974]; glycine betaine biosynthetic process from choline [GO:0019285] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; choline transmembrane transporter activity [GO:0015220]; transmembrane transporter activity [GO:0022857]; cellular response to DNA damage stimulus [GO:0006974]; glycine betaine biosynthetic process from choline [GO:0019285] choline transmembrane transporter activity [GO:0015220]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0006974; GO:0015220; GO:0016021; GO:0019285; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P27297 BAX_ECOLI Protein bax bax b3570 JW5653 bax 30,868 amidase activity [GO:0004040]; ATP binding [GO:0005524] amidase activity [GO:0004040]; ATP binding [GO:0005524] GO:0004040; GO:0005524 +P0AFT5 BTSR_ECOLI Transcriptional regulatory protein BtsR btsR yehT b2125 JW5352 yehT btsR 27,400 phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000160; GO:0000976; GO:0001216; GO:0005829; GO:0006355; GO:0032993 +P39333 BDCA_ECOLI Cyclic-di-GMP-binding biofilm dispersal mediator protein bdcA yjgI b4249 JW4207 yjgI bdcA 24,598 single-species biofilm formation [GO:0044010] cyclic-di-GMP binding [GO:0035438]; NADPH binding [GO:0070402]; oxidoreductase activity [GO:0016491]; single-species biofilm formation [GO:0044010] cyclic-di-GMP binding [GO:0035438]; NADPH binding [GO:0070402]; oxidoreductase activity [GO:0016491] GO:0016491; GO:0035438; GO:0044010; GO:0070402 +P0AEC5 BARA_ECOLI Signal transduction histidine-protein kinase BarA (EC 2.7.13.3) barA b2786 JW2757 barA 102,453 protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; response to acetate [GO:0010034]; response to formic acid [GO:1901425]; response to hydrogen peroxide [GO:0042542] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; histidine phosphotransfer kinase activity [GO:0009927]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; response to acetate [GO:0010034]; response to formic acid [GO:1901425]; response to hydrogen peroxide [GO:0042542] ATP binding [GO:0005524]; histidine phosphotransfer kinase activity [GO:0009927]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673] GO:0000155; GO:0004673; GO:0004721; GO:0005524; GO:0005886; GO:0005887; GO:0006468; GO:0009927; GO:0010034; GO:0042542; GO:0046777; GO:1901425 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +C1P605 AZUC_ECOLI Uncharacterized protein AzuC azuC b4663 JW1891.1 azuC 3,408 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:19121005, ECO:0000305|PubMed:21778229}; Peripheral membrane protein {ECO:0000305|PubMed:19121005, ECO:0000305|PubMed:21778229}. +P75925 C56I_ECOLI Cytochrome b561 homolog 2 yceJ b1057 JW1044 yceJ 20,736 respiratory electron transport chain [GO:0022904] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; respiratory electron transport chain [GO:0022904] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872] GO:0005886; GO:0009055; GO:0016021; GO:0020037; GO:0022904; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A9I1 CITE_ECOLI Citrate lyase subunit beta (Citrase beta chain) (EC 4.1.3.6) (Citrate (pro-3S)-lyase subunit beta) (Citryl-CoA lyase subunit) (EC 4.1.3.34) citE ybdW b0616 JW0608 ybdW citE 33,110 acetyl-CoA metabolic process [GO:0006084]; oxaloacetate metabolic process [GO:0006107] citrate lyase complex [GO:0009346] citrate lyase complex [GO:0009346]; citrate (pro-3S)-lyase activity [GO:0008815]; citryl-CoA lyase activity [GO:0008816]; magnesium ion binding [GO:0000287]; acetyl-CoA metabolic process [GO:0006084]; oxaloacetate metabolic process [GO:0006107] citrate (pro-3S)-lyase activity [GO:0008815]; citryl-CoA lyase activity [GO:0008816]; magnesium ion binding [GO:0000287] GO:0000287; GO:0006084; GO:0006107; GO:0008815; GO:0008816; GO:0009346 SUBCELLULAR LOCATION: Cytoplasm. +P0A986 CSPI_ECOLI Cold shock-like protein CspI (CPS-I) cspI cspJ b1552 JW1544 cspJ cspI 7,684 negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468]; response to cold [GO:0009409] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; transcription antitermination factor activity, RNA binding [GO:0001072]; negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468]; response to cold [GO:0009409] DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; transcription antitermination factor activity, RNA binding [GO:0001072] GO:0001072; GO:0003676; GO:0003677; GO:0003723; GO:0005829; GO:0009409; GO:0010468; GO:0060567 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P36562 COBT_ECOLI Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) (EC 2.4.2.21) (N(1)-alpha-phosphoribosyltransferase) cobT b1991 JW1969 cobT 36,987 cobalamin biosynthetic process [GO:0009236] nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity [GO:0008939]; cobalamin biosynthetic process [GO:0009236] nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity [GO:0008939] GO:0008939; GO:0009236 +P77580 ACDH_ECOLI Acetaldehyde dehydrogenase (EC 1.2.1.10) (Acetaldehyde dehydrogenase [acetylating]) mhpF mhpE b0351 JW0342 mhpE mhpF 33,442 3-phenylpropionate catabolic process [GO:0019380] acetaldehyde dehydrogenase (acetylating) activity [GO:0008774]; NAD binding [GO:0051287]; 3-phenylpropionate catabolic process [GO:0019380] acetaldehyde dehydrogenase (acetylating) activity [GO:0008774]; NAD binding [GO:0051287] GO:0008774; GO:0019380; GO:0051287 +P28629 ADIA_ECOLI Biodegradative arginine decarboxylase (ADC) (EC 4.1.1.19) adiA adi b4117 JW5731 adi adiA 84,425 arginine catabolic process [GO:0006527]; intracellular pH elevation [GO:0051454] cytosol [GO:0005829] cytosol [GO:0005829]; arginine decarboxylase activity [GO:0008792]; carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170]; arginine catabolic process [GO:0006527]; intracellular pH elevation [GO:0051454] arginine decarboxylase activity [GO:0008792]; carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170] GO:0005829; GO:0006527; GO:0008792; GO:0016831; GO:0030170; GO:0051454 SUBCELLULAR LOCATION: Cytoplasm. +P0AE22 APHA_ECOLI Class B acid phosphatase (CBAP) (EC 3.1.3.2) aphA napA yjbP b4055 JW4015 napA yjbP aphA 26,104 outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; acid phosphatase activity [GO:0003993]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phosphoserine phosphatase activity [GO:0004647] acid phosphatase activity [GO:0003993]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phosphoserine phosphatase activity [GO:0004647] GO:0000287; GO:0003993; GO:0004647; GO:0030288; GO:0042802 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:9011040}. +P76254 CNTB_ECOLI Carnitine monooxygenase reductase subunit (EC 1.14.13.239) (Carnitine monooxygenase beta subunit) yeaX b1803 JW1792 yeaX 35,661 carnitine metabolic process [GO:0009437] 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; carnitine metabolic process [GO:0009437] 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709] GO:0009055; GO:0009437; GO:0016709; GO:0046872; GO:0051537 +P0A6E6 ATPE_ECOLI ATP synthase epsilon chain (ATP synthase F1 sector epsilon subunit) (F-ATPase epsilon subunit) atpC papG uncC b3731 JW3709 papG uncC atpC 15,068 ATP synthesis coupled proton transport [GO:0015986] plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261] plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; ATP binding [GO:0005524]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; ATP synthesis coupled proton transport [GO:0015986] ATP binding [GO:0005524]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933] GO:0005524; GO:0005886; GO:0015986; GO:0045261; GO:0046933 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:21778229}; Peripheral membrane protein {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:21778229}. +P76460 ATOE_ECOLI Putative short-chain fatty acid transporter atoE b2223 JW2217 atoE 47,528 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0DSH2 BAXL_ECOLI Putative translational regulatory protein BaxL baxL b4794 baxL 951 negative regulation of cellular process [GO:0048523]; regulation of translation [GO:0006417] negative regulation of cellular process [GO:0048523]; regulation of translation [GO:0006417] GO:0006417; GO:0048523 +P30844 BASS_ECOLI Sensor protein BasS (EC 2.7.13.3) basS pmrB b4112 JW4073 pmrB basS 41,029 phosphorelay signal transduction system [GO:0000160]; protein autophosphorylation [GO:0046777]; response to iron(III) ion [GO:0010041]; response to zinc ion [GO:0010043]; signal transduction [GO:0007165] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673]; phosphorelay signal transduction system [GO:0000160]; protein autophosphorylation [GO:0046777]; response to iron(III) ion [GO:0010041]; response to zinc ion [GO:0010043]; signal transduction [GO:0007165] ATP binding [GO:0005524]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673] GO:0000155; GO:0000160; GO:0004673; GO:0004721; GO:0005524; GO:0005886; GO:0005887; GO:0007165; GO:0010041; GO:0010043; GO:0016020; GO:0046777 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AD99 BRNQ_ECOLI Branched-chain amino acid transport system 2 carrier protein (LIV-II) brnQ b0401 JW0391 brnQ 46,209 branched-chain amino acid transport [GO:0015803]; isoleucine transport [GO:0015818]; leucine transport [GO:0015820]; valine transport [GO:0015829] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-leucine transmembrane transporter activity [GO:0015190]; L-valine transmembrane transporter activity [GO:0005304]; branched-chain amino acid transport [GO:0015803]; isoleucine transport [GO:0015818]; leucine transport [GO:0015820]; valine transport [GO:0015829] L-isoleucine transmembrane transporter activity [GO:0015188]; L-leucine transmembrane transporter activity [GO:0015190]; L-valine transmembrane transporter activity [GO:0005304] GO:0005304; GO:0005886; GO:0015188; GO:0015190; GO:0015803; GO:0015818; GO:0015820; GO:0015829; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P37650 BCSC_ECOLI Cellulose synthase operon protein C bcsC yhjL b3530 JW5942 yhjL bcsC 127,724 cellulose biosynthetic process [GO:0030244] outer membrane [GO:0019867] outer membrane [GO:0019867]; cellulose biosynthetic process [GO:0030244] GO:0019867; GO:0030244 +P31468 CBRB_ECOLI Inner membrane protein CbrB (CreB-regulated gene B protein) cbrB yieI b3716 JW3694 yieI cbrB 16,683 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P33931 CCMA_ECOLI Cytochrome c biogenesis ATP-binding export protein CcmA (EC 7.6.2.5) (Heme exporter protein A) ccmA yejW b2201 JW5366 yejW ccmA 23,053 cytochrome complex assembly [GO:0017004]; heme transport [GO:0015886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; plasma membrane [GO:0005886]; ABC-type heme transporter activity [GO:0015439]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; cytochrome complex assembly [GO:0017004]; heme transport [GO:0015886] ABC-type heme transporter activity [GO:0015439]; ATPase activity [GO:0016887]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0015439; GO:0015886; GO:0016887; GO:0017004; GO:0031234; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01707}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01707}. +P39206 CAIE_ECOLI Carnitine operon protein CaiE caiE b0035 JW5004 caiE 21,244 carnitine metabolic process [GO:0009437] transferase activity [GO:0016740]; carnitine metabolic process [GO:0009437] transferase activity [GO:0016740] GO:0009437; GO:0016740 +P13656 CHIA_ECOLI Probable bifunctional chitinase/lysozyme [Includes: Chitinase (EC 3.2.1.14); Lysozyme (EC 3.2.1.17)] chiA yheB b3338 JW3300 yheB chiA 97,058 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] extracellular region [GO:0005576]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] extracellular region [GO:0005576]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; carbohydrate binding [GO:0030246]; chitin binding [GO:0008061]; endochitinase activity [GO:0008843]; lysozyme activity [GO:0003796]; chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] carbohydrate binding [GO:0030246]; chitin binding [GO:0008061]; endochitinase activity [GO:0008843]; lysozyme activity [GO:0003796] GO:0000272; GO:0003796; GO:0005576; GO:0006032; GO:0008061; GO:0008843; GO:0030246; GO:0030288; GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:10760150}. Note=Secreted via the Gsp type II secretion machinery under conditions of derepressed gsp gene expression. +P0AE74 CITT_ECOLI Citrate/succinate antiporter (Citrate carrier) (Citrate transporter) citT ybdS b0612 JW0604 ybdS citT 53,093 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297] antiporter activity [GO:0015297] GO:0005886; GO:0015297; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P52086 COBC_ECOLI Adenosylcobalamin/alpha-ribazole phosphatase (EC 3.1.3.73) (Adenosylcobalamin phosphatase) (Alpha-ribazole-5'-phosphate phosphatase) cobC phpB b0638 JW0633 phpB cobC 23,308 cobalamin biosynthetic process [GO:0009236] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; alpha-ribazole phosphatase activity [GO:0043755]; intramolecular transferase activity, phosphotransferases [GO:0016868]; cobalamin biosynthetic process [GO:0009236] alpha-ribazole phosphatase activity [GO:0043755]; intramolecular transferase activity, phosphotransferases [GO:0016868] GO:0005737; GO:0009236; GO:0016868; GO:0043755 +P0AE91 CREA_ECOLI Protein CreA (Catabolite regulation protein A) creA yjjD b4397 JW4360 yjjD creA 17,108 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P37685 ALDB_ECOLI Aldehyde dehydrogenase B (EC 1.2.1.4) (Acetaldehyde dehydrogenase) aldB yiaX b3588 JW3561 yiaX aldB 56,306 cellular response to DNA damage stimulus [GO:0006974]; response to ethanol [GO:0045471] aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase (NADP+) activity [GO:0033721]; oxidoreductase activity [GO:0016491]; cellular response to DNA damage stimulus [GO:0006974]; response to ethanol [GO:0045471] aldehyde dehydrogenase (NAD+) activity [GO:0004029]; aldehyde dehydrogenase (NADP+) activity [GO:0033721]; oxidoreductase activity [GO:0016491] GO:0004029; GO:0006974; GO:0016491; GO:0033721; GO:0045471 +P63883 AMIC_ECOLI N-acetylmuramoyl-L-alanine amidase AmiC (EC 3.5.1.28) amiC ygdN b2817 JW5449 ygdN amiC 45,634 cell wall organization [GO:0071555]; FtsZ-dependent cytokinesis [GO:0043093]; peptidoglycan catabolic process [GO:0009253] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; cell wall organization [GO:0071555]; FtsZ-dependent cytokinesis [GO:0043093]; peptidoglycan catabolic process [GO:0009253] N-acetylmuramoyl-L-alanine amidase activity [GO:0008745] GO:0008745; GO:0009253; GO:0030288; GO:0042597; GO:0043093; GO:0071555 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:12787347}. Note=Present throughout the periplasm in non-dividing cells, but localizes almost exclusively to a ring at the site of constriction in dividing cells. +P33997 ALPA_ECOLI DNA-binding transcriptional activator AlpA (Prophage CP4-57 regulatory protein AlpA) alpA alp b2624 JW2604 alp alpA 8,133 positive regulation of transcription, DNA-templated [GO:0045893] DNA binding [GO:0003677]; positive regulation of transcription, DNA-templated [GO:0045893] DNA binding [GO:0003677] GO:0003677; GO:0045893 +P08660 AK3_ECOLI Lysine-sensitive aspartokinase 3 (EC 2.7.2.4) (Aspartate kinase III) (AKIII) (Lysine-sensitive aspartokinase III) lysC apk b4024 JW3984 apk lysC 48,532 homoserine biosynthetic process [GO:0009090]; lysine biosynthetic process via diaminopimelate [GO:0009089] cytosol [GO:0005829] cytosol [GO:0005829]; aspartate kinase activity [GO:0004072]; ATP binding [GO:0005524]; homoserine biosynthetic process [GO:0009090]; lysine biosynthetic process via diaminopimelate [GO:0009089] aspartate kinase activity [GO:0004072]; ATP binding [GO:0005524] GO:0004072; GO:0005524; GO:0005829; GO:0009089; GO:0009090 +Q93K97 ADPP_ECOLI ADP-ribose pyrophosphatase (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (ASPPase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) nudF aspP yqiE yzzG b3034 JW3002 aspP yqiE yzzG nudF 23,667 nucleoside phosphate metabolic process [GO:0006753]; response to heat [GO:0009408]; ribose phosphate metabolic process [GO:0019693] cytosol [GO:0005829] cytosol [GO:0005829]; ADP-ribose diphosphatase activity [GO:0047631]; ADP-sugar diphosphatase activity [GO:0019144]; magnesium ion binding [GO:0000287]; pyrophosphatase activity [GO:0016462]; nucleoside phosphate metabolic process [GO:0006753]; response to heat [GO:0009408]; ribose phosphate metabolic process [GO:0019693] ADP-ribose diphosphatase activity [GO:0047631]; ADP-sugar diphosphatase activity [GO:0019144]; magnesium ion binding [GO:0000287]; pyrophosphatase activity [GO:0016462] GO:0000287; GO:0005829; GO:0006753; GO:0009408; GO:0016462; GO:0019144; GO:0019693; GO:0047631 +P00811 AMPC_ECOLI Beta-lactamase (EC 3.5.2.6) (Cephalosporinase) ampC ampA b4150 JW4111 ampA ampC 41,556 antibiotic catabolic process [GO:0017001]; response to antibiotic [GO:0046677] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; beta-lactamase activity [GO:0008800]; antibiotic catabolic process [GO:0017001]; response to antibiotic [GO:0046677] beta-lactamase activity [GO:0008800] GO:0008800; GO:0017001; GO:0030288; GO:0046677 SUBCELLULAR LOCATION: Periplasm. +P0AE30 ARTM_ECOLI Arginine ABC transporter permease protein ArtM artM b0861 JW0845 artM 24,914 amino acid transport [GO:0006865]; L-arginine import across plasma membrane [GO:0097638] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; amino acid transport [GO:0006865]; L-arginine import across plasma membrane [GO:0097638] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0006865; GO:0022857; GO:0043190; GO:0097638 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P24240 ASCB_ECOLI 6-phospho-beta-glucosidase AscB (EC 3.2.1.86) ascB b2716 JW2686 ascB 53,935 carbohydrate catabolic process [GO:0016052]; cellobiose catabolic process [GO:2000892] cytosol [GO:0005829] cytosol [GO:0005829]; 6-phospho-beta-glucosidase activity [GO:0008706]; beta-glucosidase activity [GO:0008422]; methyl beta-D-glucoside 6-phosphate glucohydrolase activity [GO:0103047]; carbohydrate catabolic process [GO:0016052]; cellobiose catabolic process [GO:2000892] 6-phospho-beta-glucosidase activity [GO:0008706]; beta-glucosidase activity [GO:0008422]; methyl beta-D-glucoside 6-phosphate glucohydrolase activity [GO:0103047] GO:0005829; GO:0008422; GO:0008706; GO:0016052; GO:0103047; GO:2000892 +P06282 CDH_ECOLI CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) (CDP-diacylglycerol phosphatidylhydrolase) (CDP-diglyceride hydrolase) cdh b3918 JW3889 cdh 28,451 CDP-diacylglycerol catabolic process [GO:0046342]; phospholipid biosynthetic process [GO:0008654] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; CDP-diacylglycerol diphosphatase activity [GO:0008715]; CDP-diacylglycerol catabolic process [GO:0046342]; phospholipid biosynthetic process [GO:0008654] CDP-diacylglycerol diphosphatase activity [GO:0008715] GO:0005886; GO:0008654; GO:0008715; GO:0016021; GO:0046342 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein. +P0ABH7 CISY_ECOLI Citrate synthase (EC 2.3.3.16) gltA gluT icdB b0720 JW0710 gluT icdB gltA 48,015 protein hexamerization [GO:0034214]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829] cytosol [GO:0005829]; citrate (Si)-synthase activity [GO:0004108]; identical protein binding [GO:0042802]; NADH binding [GO:0070404]; protein hexamerization [GO:0034214]; tricarboxylic acid cycle [GO:0006099] citrate (Si)-synthase activity [GO:0004108]; identical protein binding [GO:0042802]; NADH binding [GO:0070404] GO:0004108; GO:0005829; GO:0006099; GO:0034214; GO:0042802; GO:0070404 +P37019 CLCA_ECOLI H(+)/Cl(-) exchange transporter ClcA (ClC-ec1) clcA eriC yadQ b0155 JW5012 eriC yadQ clcA 50,349 cellular stress response to acidic pH [GO:1990451]; chloride transmembrane transport [GO:1902476]; proton transmembrane transport [GO:1902600] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; chloride transmembrane transporter activity [GO:0015108]; chloride:proton antiporter activity [GO:0062158]; identical protein binding [GO:0042802]; solute:proton antiporter activity [GO:0015299]; voltage-gated chloride channel activity [GO:0005247]; cellular stress response to acidic pH [GO:1990451]; chloride transmembrane transport [GO:1902476]; proton transmembrane transport [GO:1902600] chloride:proton antiporter activity [GO:0062158]; chloride transmembrane transporter activity [GO:0015108]; identical protein binding [GO:0042802]; solute:proton antiporter activity [GO:0015299]; voltage-gated chloride channel activity [GO:0005247] GO:0005247; GO:0005886; GO:0005887; GO:0015108; GO:0015299; GO:0042802; GO:0062158; GO:1902476; GO:1902600; GO:1990451 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P21189 DPO2_ECOLI DNA polymerase II (Pol II) (EC 2.7.7.7) polB dinA b0060 JW0059 dinA polB 90,053 DNA-dependent DNA replication [GO:0006261]; DNA replication proofreading [GO:0045004]; SOS response [GO:0009432] 3'-5'-exodeoxyribonuclease activity [GO:0008296]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166]; DNA replication proofreading [GO:0045004]; DNA-dependent DNA replication [GO:0006261]; SOS response [GO:0009432] 3'-5'-exodeoxyribonuclease activity [GO:0008296]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; nucleotide binding [GO:0000166] GO:0000166; GO:0003677; GO:0003887; GO:0006261; GO:0008296; GO:0009432; GO:0045004 +P10443 DPO3A_ECOLI DNA polymerase III subunit alpha (EC 2.7.7.7) dnaE polC b0184 JW0179 polC dnaE 129,905 DNA replication [GO:0006260]; nucleic acid phosphodiester bond hydrolysis [GO:0090305] cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA polymerase III, core complex [GO:0044776] cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA polymerase III, core complex [GO:0044776]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; DNA replication [GO:0006260]; nucleic acid phosphodiester bond hydrolysis [GO:0090305] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887] GO:0003677; GO:0003887; GO:0005737; GO:0005829; GO:0006260; GO:0044776; GO:0090305 SUBCELLULAR LOCATION: Cytoplasm. +P0AE95 CSGE_ECOLI Curli production assembly/transport component CsgE csgE b1039 JW1022 csgE 14,879 biological adhesion [GO:0022610]; protein transmembrane transport [GO:0071806]; single-species biofilm formation [GO:0044010] cell outer membrane [GO:0009279]; outer membrane-bounded periplasmic space [GO:0030288] cell outer membrane [GO:0009279]; outer membrane-bounded periplasmic space [GO:0030288]; identical protein binding [GO:0042802]; biological adhesion [GO:0022610]; protein transmembrane transport [GO:0071806]; single-species biofilm formation [GO:0044010] identical protein binding [GO:0042802] GO:0009279; GO:0022610; GO:0030288; GO:0042802; GO:0044010; GO:0071806 +P0AE98 CSGF_ECOLI Curli production assembly/transport component CsgF csgF b1038 JW1021 csgF 15,056 curli assembly [GO:0098775]; single-species biofilm formation [GO:0044010] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; curli assembly [GO:0098775]; single-species biofilm formation [GO:0044010] GO:0009279; GO:0044010; GO:0098775 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:16522795}. +P0A968 CSPD_ECOLI Cold shock-like protein CspD (CSP-D) cspD cspH ybjA b0880 JW0864 cspH ybjA cspD 7,969 negative regulation of DNA replication [GO:0008156]; regulation of gene expression [GO:0010468]; regulation of transcription, DNA-templated [GO:0006355]; response to starvation [GO:0042594] cytosol [GO:0005829] cytosol [GO:0005829]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; toxin activity [GO:0090729]; negative regulation of DNA replication [GO:0008156]; regulation of gene expression [GO:0010468]; regulation of transcription, DNA-templated [GO:0006355]; response to starvation [GO:0042594] nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; toxin activity [GO:0090729] GO:0003676; GO:0003697; GO:0003723; GO:0005829; GO:0006355; GO:0008156; GO:0010468; GO:0042594; GO:0090729 SUBCELLULAR LOCATION: Cytoplasm. +P31441 ADEC_ECOLI Adenine deaminase (Adenase) (Adenine aminase) (EC 3.5.4.2) ade yicP b3665 JW3640 yicP ade 63,739 adenine catabolic process [GO:0006146] adenine deaminase activity [GO:0000034]; catalase activity [GO:0004096]; ferrous iron binding [GO:0008198]; manganese ion binding [GO:0030145]; adenine catabolic process [GO:0006146] adenine deaminase activity [GO:0000034]; catalase activity [GO:0004096]; ferrous iron binding [GO:0008198]; manganese ion binding [GO:0030145] GO:0000034; GO:0004096; GO:0006146; GO:0008198; GO:0030145 +P0DSE4 ARGL_ECOLI Putative translational regulatory protein ArgL argL b4766 argL 3,681 negative regulation of cellular process [GO:0048523]; regulation of translation [GO:0006417] negative regulation of cellular process [GO:0048523]; regulation of translation [GO:0006417] GO:0006417; GO:0048523 +P0AD70 AMPH_ECOLI D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH (EC 3.4.-.-) (DD-alanine-endopeptidase) (DD-carboxypeptidase) (Penicillin-binding protein AmpH) ampH yaiH b0376 JW5052 yaiH ampH 41,849 cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253]; regulation of cell shape [GO:0008360] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; carboxypeptidase activity [GO:0004180]; endopeptidase activity [GO:0004175]; penicillin binding [GO:0008658]; cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253]; regulation of cell shape [GO:0008360] carboxypeptidase activity [GO:0004180]; endopeptidase activity [GO:0004175]; penicillin binding [GO:0008658] GO:0004175; GO:0004180; GO:0005886; GO:0008360; GO:0008658; GO:0009253; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:22001512}. +P12995 BIOA_ECOLI Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) (7,8-diamino-pelargonic acid aminotransferase) (DAPA AT) (DAPA aminotransferase) (7,8-diaminononanoate synthase) (DANS) (Diaminopelargonic acid synthase) bioA b0774 JW0757 bioA 47,336 biotin biosynthetic process [GO:0009102] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; adenosylmethionine-8-amino-7-oxononanoate transaminase activity [GO:0004015]; pyridoxal phosphate binding [GO:0030170]; biotin biosynthetic process [GO:0009102] adenosylmethionine-8-amino-7-oxononanoate transaminase activity [GO:0004015]; pyridoxal phosphate binding [GO:0030170] GO:0004015; GO:0005737; GO:0009102; GO:0030170 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P0A940 BAMA_ECOLI Outer membrane protein assembly factor BamA (Omp85) bamA yaeT yzzN yzzY b0177 JW0172 yaeT yzzN yzzY bamA 90,553 cell adhesion [GO:0007155]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; protein insertion into membrane [GO:0051205] Bam protein complex [GO:1990063]; cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] Bam protein complex [GO:1990063]; cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; cell adhesion [GO:0007155]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; protein insertion into membrane [GO:0051205] GO:0007155; GO:0009279; GO:0016021; GO:0043165; GO:0051205; GO:1990063 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_01430, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:23882017, ECO:0000269|PubMed:24619089, ECO:0000269|PubMed:24914988, ECO:0000269|PubMed:26901871, ECO:0000269|PubMed:9298646}. +P26218 BGLH_ECOLI Cryptic outer membrane porin BglH bglH yieC b3720 JW3698 yieC bglH 60,657 carbohydrate transmembrane transport [GO:0034219]; polysaccharide transport [GO:0015774] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; pore complex [GO:0046930]; carbohydrate transmembrane transporter activity [GO:0015144]; porin activity [GO:0015288]; carbohydrate transmembrane transport [GO:0034219]; polysaccharide transport [GO:0015774] carbohydrate transmembrane transporter activity [GO:0015144]; porin activity [GO:0015288] GO:0009279; GO:0015144; GO:0015288; GO:0015774; GO:0034219; GO:0045203; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305|PubMed:10027967}; Multi-pass membrane protein {ECO:0000305|PubMed:10027967}. Note=Can be easily removed from the outer membrane by treatment with detergent. +P37652 BCSB_ECOLI Cyclic di-GMP-binding protein (Cellulose synthase regulatory subunit) bcsB yhjN b3532 JW3500 yhjN bcsB 86,024 cellulose biosynthetic process [GO:0030244]; UDP-glucose metabolic process [GO:0006011] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cellulose biosynthetic process [GO:0030244]; UDP-glucose metabolic process [GO:0006011] GO:0005886; GO:0006011; GO:0016021; GO:0030244 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass type I membrane protein. +P17411 CHBF_ECOLI 6-phospho-beta-glucosidase (EC 3.2.1.86) (Cellobiose-6-phosphate hydrolase) (Phospho-chitobiase) chbF celF ydjD b1734 JW1723 celF ydjD chbF 50,513 carbohydrate metabolic process [GO:0005975] 6-phospho-beta-glucosidase activity [GO:0008706]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methyl beta-D-glucoside 6-phosphate glucohydrolase activity [GO:0103047]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; carbohydrate metabolic process [GO:0005975] 6-phospho-beta-glucosidase activity [GO:0008706]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; methyl beta-D-glucoside 6-phosphate glucohydrolase activity [GO:0103047]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] GO:0005975; GO:0008706; GO:0016616; GO:0042802; GO:0046872; GO:0103047 +P76213 CHO_ECOLI Excinuclease cho (EC 3.1.25.-) (Endonuclease cho) (UvrC homolog protein) cho dinM sosD ydjQ b1741 JW1730 dinM sosD ydjQ cho 33,739 cellular response to DNA damage stimulus [GO:0006974]; nucleotide-excision repair, DNA incision [GO:0033683]; SOS response [GO:0009432] excinuclease repair complex [GO:0009380] excinuclease repair complex [GO:0009380]; endodeoxyribonuclease activity [GO:0004520]; cellular response to DNA damage stimulus [GO:0006974]; nucleotide-excision repair, DNA incision [GO:0033683]; SOS response [GO:0009432] endodeoxyribonuclease activity [GO:0004520] GO:0004520; GO:0006974; GO:0009380; GO:0009432; GO:0033683 +P45955 CPOB_ECOLI Cell division coordinator CpoB cpoB ybgF b0742 JW0732 ybgF cpoB 28,231 cell division [GO:0051301]; FtsZ-dependent cytokinesis [GO:0043093]; protein trimerization [GO:0070206] outer membrane-bounded periplasmic space [GO:0030288]; protein-containing complex [GO:0032991] outer membrane-bounded periplasmic space [GO:0030288]; protein-containing complex [GO:0032991]; cell division [GO:0051301]; FtsZ-dependent cytokinesis [GO:0043093]; protein trimerization [GO:0070206] GO:0030288; GO:0032991; GO:0043093; GO:0051301; GO:0070206 SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_02066, ECO:0000269|PubMed:8763928}. Note=Targeting to the Sec-translocase for transport across the inner membrane is SecB-dependent (PubMed:16352602). Localizes to the septum concurrent with PBP1B-LpoB and Tol at the onset of constriction (PubMed:25951518). Localization is dependent on divisome assembly and requires ongoing septal peptidoglycan synthesis (PubMed:25951518). {ECO:0000269|PubMed:16352602, ECO:0000269|PubMed:25951518}. +P37002 CRCB_ECOLI Putative fluoride ion transporter CrcB crcB ybeI b0624 JW0619 ybeI crcB 13,777 cellular detoxification of fluoride [GO:0140114]; fluoride transmembrane transport [GO:1903424] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; anion channel activity [GO:0005253]; fluoride transmembrane transporter activity [GO:1903425]; cellular detoxification of fluoride [GO:0140114]; fluoride transmembrane transport [GO:1903424] anion channel activity [GO:0005253]; fluoride transmembrane transporter activity [GO:1903425] GO:0005253; GO:0005886; GO:0005887; GO:0140114; GO:1903424; GO:1903425 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00454, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:16429150}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00454, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:16429150}. Note=Could be a dual-topology protein, which inserts into the membrane in two opposite orientations. May form an antiparallel homodimer in the inner membrane. +P0ACJ8 CRP_ECOLI cAMP-activated global transcriptional regulator CRP (Catabolite activator protein) (CAP) (Catabolite gene activator) (cAMP receptor protein) (CRP) (cAMP regulatory protein) crp cap csm b3357 JW5702 cap csm crp 23,640 carbon catabolite repression of transcription [GO:0045013]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; cAMP binding [GO:0030552]; DNA binding, bending [GO:0008301]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; sequence-specific DNA binding [GO:0043565]; carbon catabolite repression of transcription [GO:0045013]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] cAMP binding [GO:0030552]; DNA binding, bending [GO:0008301]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; sequence-specific DNA binding [GO:0043565] GO:0003680; GO:0003700; GO:0005829; GO:0006351; GO:0008301; GO:0030552; GO:0032993; GO:0042802; GO:0043565; GO:0045013; GO:0045892; GO:0045893 +P28248 DCD_ECOLI dCTP deaminase (EC 3.5.4.13) (Deoxycytidine triphosphate deaminase) dcd dus paxA b2065 JW2050 dus paxA dcd 21,249 dTTP biosynthetic process [GO:0006235]; dUMP biosynthetic process [GO:0006226]; dUTP biosynthetic process [GO:0006229]; nucleobase-containing small molecule interconversion [GO:0015949]; protein homotrimerization [GO:0070207]; response to radiation [GO:0009314] cytosol [GO:0005829] cytosol [GO:0005829]; dCTP deaminase activity [GO:0008829]; nucleotide binding [GO:0000166]; dTTP biosynthetic process [GO:0006235]; dUMP biosynthetic process [GO:0006226]; dUTP biosynthetic process [GO:0006229]; nucleobase-containing small molecule interconversion [GO:0015949]; protein homotrimerization [GO:0070207]; response to radiation [GO:0009314] dCTP deaminase activity [GO:0008829]; nucleotide binding [GO:0000166] GO:0000166; GO:0005829; GO:0006226; GO:0006229; GO:0006235; GO:0008829; GO:0009314; GO:0015949; GO:0070207 +P0A6K3 DEF_ECOLI Peptide deformylase (PDF) (EC 3.5.1.88) (Polypeptide deformylase) def fms b3287 JW3248 fms def 19,328 co-translational protein modification [GO:0043686]; N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; translation [GO:0006412] cytosol [GO:0005829] cytosol [GO:0005829]; ferrous iron binding [GO:0008198]; hydrolase activity [GO:0016787]; peptide deformylase activity [GO:0042586]; ribosome binding [GO:0043022]; zinc ion binding [GO:0008270]; co-translational protein modification [GO:0043686]; N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; translation [GO:0006412] ferrous iron binding [GO:0008198]; hydrolase activity [GO:0016787]; peptide deformylase activity [GO:0042586]; ribosome binding [GO:0043022]; zinc ion binding [GO:0008270] GO:0005829; GO:0006412; GO:0008198; GO:0008270; GO:0016787; GO:0018206; GO:0031365; GO:0042586; GO:0043022; GO:0043686 +P0A9P0 DLDH_ECOLI Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) (Glycine cleavage system L protein) lpdA lpd b0116 JW0112 lpd lpdA 50,688 2-oxoglutarate metabolic process [GO:0006103]; cell redox homeostasis [GO:0045454]; glycine decarboxylation via glycine cleavage system [GO:0019464]; glycolytic process [GO:0006096]; pyruvate metabolic process [GO:0006090]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic pyruvate dehydrogenase complex [GO:0045250]; membrane [GO:0016020]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic pyruvate dehydrogenase complex [GO:0045250]; membrane [GO:0016020]; plasma membrane [GO:0005886]; dihydrolipoyl dehydrogenase activity [GO:0004148]; disulfide oxidoreductase activity [GO:0015036]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; 2-oxoglutarate metabolic process [GO:0006103]; cell redox homeostasis [GO:0045454]; glycine decarboxylation via glycine cleavage system [GO:0019464]; glycolytic process [GO:0006096]; pyruvate metabolic process [GO:0006090]; response to oxidative stress [GO:0006979] dihydrolipoyl dehydrogenase activity [GO:0004148]; disulfide oxidoreductase activity [GO:0015036]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] GO:0004148; GO:0005737; GO:0005829; GO:0005886; GO:0006090; GO:0006096; GO:0006103; GO:0006979; GO:0008270; GO:0015036; GO:0016020; GO:0019464; GO:0042802; GO:0045250; GO:0045454; GO:0050660 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16079137}. Cell inner membrane {ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000269|PubMed:16079137}. +P31129 DGCZ_ECOLI Diguanylate cyclase DgcZ (DGC) (EC 2.7.7.65) (Zinc-sensory diguanylate cyclase) dgcZ ydeG ydeH b1535 JW1528 ydeG ydeH dgcZ 33,863 cell adhesion involved in single-species biofilm formation [GO:0043709]; metabolic process [GO:0008152]; negative regulation of bacterial-type flagellum assembly [GO:1902209]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201]; negative regulation of cellular component movement [GO:0051271]; positive regulation of single-species biofilm formation on inanimate substrate [GO:1900233] cell pole [GO:0060187]; plasma membrane [GO:0005886] cell pole [GO:0060187]; plasma membrane [GO:0005886]; diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; cell adhesion involved in single-species biofilm formation [GO:0043709]; metabolic process [GO:0008152]; negative regulation of bacterial-type flagellum assembly [GO:1902209]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201]; negative regulation of cellular component movement [GO:0051271]; positive regulation of single-species biofilm formation on inanimate substrate [GO:1900233] diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] GO:0005525; GO:0005886; GO:0008152; GO:0008270; GO:0042802; GO:0043709; GO:0051271; GO:0052621; GO:0060187; GO:1900233; GO:1902201; GO:1902209 +P67603 AC4CH_ECOLI N(4)-acetylcytidine amidohydrolase (ac4C amidohydrolase) (EC 3.5.1.135) yqfB b2900 JW2868 yqfB 11,905 cytosol [GO:0005829] cytosol [GO:0005829]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [GO:0016813]; N4-acetylcytidine amidohydrolase activity [GO:0106251] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [GO:0016813]; N4-acetylcytidine amidohydrolase activity [GO:0106251] GO:0005829; GO:0016813; GO:0106251 +P76578 A2MG_ECOLI Alpha-2-macroglobulin (ECAM) yfhM b2520 JW2504 yfhM 181,585 negative regulation of endopeptidase activity [GO:0010951] anchored component of external side of plasma membrane [GO:0031362]; extracellular space [GO:0005615] anchored component of external side of plasma membrane [GO:0031362]; extracellular space [GO:0005615]; endopeptidase inhibitor activity [GO:0004866]; negative regulation of endopeptidase activity [GO:0010951] endopeptidase inhibitor activity [GO:0004866] GO:0004866; GO:0005615; GO:0010951; GO:0031362 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:18697741, ECO:0000269|PubMed:21210718}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}; Periplasmic side {ECO:0000269|PubMed:18697741}. +P0A6A3 ACKA_ECOLI Acetate kinase (EC 2.7.2.1) (Acetokinase) ackA ack b2296 JW2293 ack ackA 43,290 acetate biosynthetic process [GO:0019413]; acetate metabolic process [GO:0006083]; acetyl-CoA biosynthetic process [GO:0006085]; propionate biosynthetic process [GO:0019542]; single-species biofilm formation on inanimate substrate [GO:0044011] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; acetate kinase activity [GO:0008776]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270]; acetate biosynthetic process [GO:0019413]; acetate metabolic process [GO:0006083]; acetyl-CoA biosynthetic process [GO:0006085]; propionate biosynthetic process [GO:0019542]; single-species biofilm formation on inanimate substrate [GO:0044011] acetate kinase activity [GO:0008776]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270] GO:0000287; GO:0005524; GO:0005829; GO:0006083; GO:0006085; GO:0008270; GO:0008776; GO:0016020; GO:0019413; GO:0019542; GO:0044011 SUBCELLULAR LOCATION: Cytoplasm. +P60061 ADIC_ECOLI Arginine/agmatine antiporter adiC aniC yjdD yjdE b4115 JW4076 aniC yjdD yjdE adiC 46,843 amino acid transmembrane transport [GO:0003333]; intracellular pH elevation [GO:0051454] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297]; arginine transmembrane transporter activity [GO:0015181]; amino acid transmembrane transport [GO:0003333]; intracellular pH elevation [GO:0051454] antiporter activity [GO:0015297]; arginine transmembrane transporter activity [GO:0015181] GO:0003333; GO:0005886; GO:0005887; GO:0015181; GO:0015297; GO:0051454 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0ACK2 AGAR_ECOLI Putative aga operon transcriptional repressor agaR yhaW b3131 JW3100 yhaW agaR 29,572 regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006355 +P27550 ACSA_ECOLI Acetyl-coenzyme A synthetase (AcCoA synthetase) (Acs) (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) acs yfaC b4069 JW4030 yfaC acs 72,094 acetate catabolic process [GO:0045733]; acetyl-CoA biosynthetic process from acetate [GO:0019427]; chemotaxis [GO:0006935]; peptidyl-lysine acetylation [GO:0018394]; post-translational protein acetylation [GO:0034421] cytosol [GO:0005829] cytosol [GO:0005829]; acetate-CoA ligase activity [GO:0003987]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; propionate-CoA ligase activity [GO:0050218]; protein deacetylase activity [GO:0033558]; acetate catabolic process [GO:0045733]; acetyl-CoA biosynthetic process from acetate [GO:0019427]; chemotaxis [GO:0006935]; peptidyl-lysine acetylation [GO:0018394]; post-translational protein acetylation [GO:0034421] acetate-CoA ligase activity [GO:0003987]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; propionate-CoA ligase activity [GO:0050218]; protein deacetylase activity [GO:0033558] GO:0003987; GO:0005524; GO:0005829; GO:0006935; GO:0016208; GO:0018394; GO:0019427; GO:0033558; GO:0034421; GO:0045733; GO:0046872; GO:0050218 +P76474 ARNF_ECOLI Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF (L-Ara4N-phosphoundecaprenol flippase subunit ArnF) (Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF) arnF pmrM yfbJ b2258 JW5373 pmrM yfbJ arnF 14,085 carbohydrate derivative transport [GO:1901264]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; response to iron(III) ion [GO:0010041]; transmembrane transport [GO:0055085] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; carbohydrate derivative transmembrane transporter activity [GO:1901505]; transmembrane transporter activity [GO:0022857]; carbohydrate derivative transport [GO:1901264]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; response to iron(III) ion [GO:0010041]; transmembrane transport [GO:0055085] carbohydrate derivative transmembrane transporter activity [GO:1901505]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0009103; GO:0009245; GO:0010041; GO:0022857; GO:0055085; GO:1901264; GO:1901505 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P12008 AROC_ECOLI Chorismate synthase (CS) (EC 4.2.3.5) (5-enolpyruvylshikimate-3-phosphate phospholyase) (EPSP phospholyase) aroC b2329 JW2326 aroC 39,137 aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] cytosol [GO:0005829] cytosol [GO:0005829]; chorismate synthase activity [GO:0004107]; FMN binding [GO:0010181]; identical protein binding [GO:0042802]; aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] chorismate synthase activity [GO:0004107]; FMN binding [GO:0010181]; identical protein binding [GO:0042802] GO:0004107; GO:0005829; GO:0008652; GO:0009073; GO:0009423; GO:0010181; GO:0042802 +P37309 ARSR_ECOLI Arsenical resistance operon repressor arsR arsE b3501 JW3468 arsE arsR 13,253 regulation of transcription, DNA-templated [GO:0006355]; response to arsenic-containing substance [GO:0046685]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355]; response to arsenic-containing substance [GO:0046685]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003677; GO:0003700; GO:0006351; GO:0006355; GO:0046685 +P77398 ARNA_ECOLI Bifunctional polymyxin resistance protein ArnA (Polymyxin resistance protein PmrI) [Includes: UDP-4-amino-4-deoxy-L-arabinose formyltransferase (EC 2.1.2.13) (ArnAFT) (UDP-L-Ara4N formyltransferase); UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating (EC 1.1.1.305) (ArnADH) (UDP-GlcUA decarboxylase) (UDP-glucuronic acid dehydrogenase)] arnA pmrI yfbG b2255 JW2249 pmrI yfbG arnA 74,289 lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; response to antibiotic [GO:0046677]; UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthetic process [GO:2001315]; UDP-D-xylose biosynthetic process [GO:0033320] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; NAD+ binding [GO:0070403]; UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity [GO:0099619]; UDP-glucuronate decarboxylase activity [GO:0048040]; UDP-glucuronic acid dehydrogenase activity [GO:0099618]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; response to antibiotic [GO:0046677]; UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthetic process [GO:2001315]; UDP-D-xylose biosynthetic process [GO:0033320] identical protein binding [GO:0042802]; NAD+ binding [GO:0070403]; UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity [GO:0099619]; UDP-glucuronate decarboxylase activity [GO:0048040]; UDP-glucuronic acid dehydrogenase activity [GO:0099618] GO:0009103; GO:0009245; GO:0032991; GO:0033320; GO:0042802; GO:0046677; GO:0048040; GO:0070403; GO:0099618; GO:0099619; GO:2001315 +P0A6H8 CLSA_ECOLI Cardiolipin synthase A (CL synthase) (EC 2.7.8.-) clsA cls nov yciJ b1249 JW1241 cls nov yciJ clsA 54,822 cardiolipin biosynthetic process [GO:0032049] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cardiolipin synthase activity [GO:0008808]; cardiolipin biosynthetic process [GO:0032049] cardiolipin synthase activity [GO:0008808] GO:0005886; GO:0008808; GO:0016020; GO:0016021; GO:0032049 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00190, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:1663113, ECO:0000269|PubMed:19341704}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00190, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:1663113}. +P09053 AVTA_ECOLI Valine--pyruvate aminotransferase (EC 2.6.1.66) (Alanine--valine transaminase) (Transaminase C) avtA b3572 JW5652 avtA 46,711 alpha-amino acid metabolic process [GO:1901605]; D-alanine biosynthetic process [GO:0030632]; valine biosynthetic process [GO:0009099] cytosol [GO:0005829] cytosol [GO:0005829]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]; valine-pyruvate transaminase activity [GO:0009042]; alpha-amino acid metabolic process [GO:1901605]; D-alanine biosynthetic process [GO:0030632]; valine biosynthetic process [GO:0009099] pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]; valine-pyruvate transaminase activity [GO:0009042] GO:0005829; GO:0008483; GO:0009042; GO:0009099; GO:0030170; GO:0030632; GO:1901605 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +Q06065 ATOC_ECOLI Regulatory protein AtoC (Acetoacetate metabolism regulatory protein) (DNA-binding transcriptional regulator AtoC) (Ornithine decarboxylase antizyme) atoC az b2220 JW2214 az atoC 52,176 phosphorelay signal transduction system [GO:0000160]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of polyamine biosynthetic process [GO:0010967] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; DNA-binding transcription factor activity [GO:0003700]; ornithine decarboxylase inhibitor activity [GO:0008073]; sequence-specific DNA binding [GO:0043565]; transcription factor binding [GO:0008134]; phosphorelay signal transduction system [GO:0000160]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of polyamine biosynthetic process [GO:0010967] ATP binding [GO:0005524]; DNA-binding transcription factor activity [GO:0003700]; ornithine decarboxylase inhibitor activity [GO:0008073]; sequence-specific DNA binding [GO:0043565]; transcription factor binding [GO:0008134] GO:0000160; GO:0003700; GO:0005524; GO:0005737; GO:0008073; GO:0008134; GO:0010967; GO:0043565; GO:0045893 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16153782}. Note=Membrane-associated in the presence of AtoS. {ECO:0000269|PubMed:16153782}. +P76458 ATOD_ECOLI Acetate CoA-transferase subunit alpha (EC 2.8.3.8) (Acetyl-CoA:acetoacetate-CoA transferase subunit alpha) atoD b2221 JW2215 atoD 23,526 short-chain fatty acid metabolic process [GO:0046459] acetate CoA-transferase activity [GO:0008775]; CoA-transferase activity [GO:0008410]; short-chain fatty acid metabolic process [GO:0046459] acetate CoA-transferase activity [GO:0008775]; CoA-transferase activity [GO:0008410] GO:0008410; GO:0008775; GO:0046459 +P76459 ATOA_ECOLI Acetate CoA-transferase subunit beta (EC 2.8.3.8) (Acetyl-CoA:acetoacetate CoA-transferase subunit beta) atoA b2222 JW2216 atoA 22,960 short-chain fatty acid metabolic process [GO:0046459] acetate CoA-transferase activity [GO:0008775]; CoA-transferase activity [GO:0008410]; short-chain fatty acid metabolic process [GO:0046459] acetate CoA-transferase activity [GO:0008775]; CoA-transferase activity [GO:0008410] GO:0008410; GO:0008775; GO:0046459 +P66948 BEPA_ECOLI Beta-barrel assembly-enhancing protease (EC 3.4.-.-) bepA yfgC b2494 JW2479 yfgC bepA 53,908 chaperone-mediated protein folding [GO:0061077]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; proteolysis involved in cellular protein catabolic process [GO:0051603] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; protein disulfide isomerase activity [GO:0003756]; zinc ion binding [GO:0008270]; chaperone-mediated protein folding [GO:0061077]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; proteolysis involved in cellular protein catabolic process [GO:0051603] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; protein disulfide isomerase activity [GO:0003756]; zinc ion binding [GO:0008270] GO:0003756; GO:0004222; GO:0008270; GO:0016020; GO:0030288; GO:0043165; GO:0046872; GO:0051603; GO:0061077 SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00997, ECO:0000269|PubMed:22491786, ECO:0000269|PubMed:24003122}. Note=A significant amount of BepA is membrane-associated. This localization could result from interaction with the BAM complex. +P0ADJ5 BCSF_ECOLI Cellulose biosynthesis protein BcsF bcsF yhjT b3537 JW5663 yhjT bcsF 7,364 cellulose biosynthetic process [GO:0030244] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cellulose biosynthetic process [GO:0030244] GO:0005886; GO:0016021; GO:0030244 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P11988 BGLB_ECOLI 6-phospho-beta-glucosidase BglB (EC 3.2.1.86) (Phospho-beta-glucosidase B) bglB b3721 JW3699 bglB 53,161 carbohydrate catabolic process [GO:0016052] cytosol [GO:0005829] cytosol [GO:0005829]; 6-phospho-beta-glucosidase activity [GO:0008706]; beta-glucosidase activity [GO:0008422]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; methyl beta-D-glucoside 6-phosphate glucohydrolase activity [GO:0103047]; carbohydrate catabolic process [GO:0016052] 6-phospho-beta-glucosidase activity [GO:0008706]; beta-glucosidase activity [GO:0008422]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; methyl beta-D-glucoside 6-phosphate glucohydrolase activity [GO:0103047] GO:0004553; GO:0005829; GO:0008422; GO:0008706; GO:0016052; GO:0103047 +P17315 CIRA_ECOLI Colicin I receptor cirA cir feuA b2155 JW2142 cir feuA cirA 73,896 iron ion homeostasis [GO:0055072]; siderophore transmembrane transport [GO:0044718] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; intrinsic component of cell outer membrane [GO:0031230] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; intrinsic component of cell outer membrane [GO:0031230]; colicin transmembrane transporter activity [GO:0042912]; siderophore transmembrane transporter activity [GO:0015343]; siderophore uptake transmembrane transporter activity [GO:0015344]; iron ion homeostasis [GO:0055072]; siderophore transmembrane transport [GO:0044718] colicin transmembrane transporter activity [GO:0042912]; siderophore transmembrane transporter activity [GO:0015343]; siderophore uptake transmembrane transporter activity [GO:0015344] GO:0009279; GO:0015343; GO:0015344; GO:0016021; GO:0031230; GO:0042912; GO:0044718; GO:0055072 SUBCELLULAR LOCATION: Cell outer membrane. +P0A8Q6 CLPS_ECOLI ATP-dependent Clp protease adapter protein ClpS clpS yljA b0881 JW0865 yljA clpS 12,179 protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; response to heat [GO:0009408] chaperone binding [GO:0051087]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]; response to heat [GO:0009408] chaperone binding [GO:0051087] GO:0006508; GO:0009408; GO:0030163; GO:0051087 +Q46901 CSE1_ECOLI CRISPR system Cascade subunit CasA (CRISPR type I-E/Ecoli-associated protein CasA/Cse1) (CRISPR-associated protein CasA/Cse1) casA cse1 ygcL b2760 JW2730 cse1 ygcL casA 55,901 defense response to virus [GO:0051607] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; defense response to virus [GO:0051607] DNA binding [GO:0003677]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270] GO:0003677; GO:0003723; GO:0008270; GO:0032991; GO:0051607 +P36561 COBS_ECOLI Adenosylcobinamide-GDP ribazoletransferase (EC 2.7.8.26) (Cobalamin synthase) (Cobalamin-5'-phosphate synthase) cobS b1992 JW1970 cobS 26,386 cobalamin biosynthetic process [GO:0009236] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; adenosylcobinamide-GDP ribazoletransferase activity [GO:0051073]; cobalamin 5'-phosphate synthase activity [GO:0008818]; cobalamin biosynthetic process [GO:0009236] adenosylcobinamide-GDP ribazoletransferase activity [GO:0051073]; cobalamin 5'-phosphate synthase activity [GO:0008818] GO:0005886; GO:0008818; GO:0009236; GO:0016021; GO:0051073 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0A6J1 CYSC_ECOLI Adenylyl-sulfate kinase (EC 2.7.1.25) (APS kinase) (ATP adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenosine-5'-phosphosulfate kinase) cysC b2750 JW2720 cysC 22,321 hydrogen sulfide biosynthetic process [GO:0070814]; phosphorylation [GO:0016310]; sulfate assimilation [GO:0000103] adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; hydrogen sulfide biosynthetic process [GO:0070814]; phosphorylation [GO:0016310]; sulfate assimilation [GO:0000103] adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; identical protein binding [GO:0042802] GO:0000103; GO:0004020; GO:0005524; GO:0016310; GO:0042802; GO:0070814 +P02924 ARAF_ECOLI L-arabinose-binding periplasmic protein (ABP) araF b1901 JW1889 araF 35,541 L-arabinose transmembrane transport [GO:0042882] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; ABC-type monosaccharide transporter activity [GO:0015407]; carbohydrate binding [GO:0030246]; monosaccharide binding [GO:0048029]; L-arabinose transmembrane transport [GO:0042882] ABC-type monosaccharide transporter activity [GO:0015407]; carbohydrate binding [GO:0030246]; monosaccharide binding [GO:0048029] GO:0015407; GO:0030246; GO:0030288; GO:0042882; GO:0048029 SUBCELLULAR LOCATION: Periplasm. +P05637 APAH_ECOLI Bis(5'-nucleosyl)-tetraphosphatase [symmetrical] (EC 3.6.1.41) (Ap4A hydrolase) (Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase) (Diadenosine tetraphosphatase) apaH b0049 JW0048 apaH 31,297 nucleobase-containing small molecule interconversion [GO:0015949]; response to X-ray [GO:0010165]; RNA decapping [GO:0110154] bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity [GO:0008803]; bis(5'-nucleosyl)-tetraphosphatase activity [GO:0008796]; nucleobase-containing small molecule interconversion [GO:0015949]; response to X-ray [GO:0010165]; RNA decapping [GO:0110154] bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity [GO:0008803]; bis(5'-nucleosyl)-tetraphosphatase activity [GO:0008796] GO:0008796; GO:0008803; GO:0010165; GO:0015949; GO:0110154 +P30859 ARTI_ECOLI Putative ABC transporter arginine-binding protein 2 artI b0863 JW0847 artI 26,930 amino acid transport [GO:0006865] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; ligand-gated ion channel activity [GO:0015276]; amino acid transport [GO:0006865] ligand-gated ion channel activity [GO:0015276] GO:0006865; GO:0015276; GO:0016020; GO:0030288; GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:8801422}. +P00887 AROH_ECOLI Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive (EC 2.5.1.54) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) (DAHP synthase) (Phospho-2-keto-3-deoxyheptonate aldolase) aroH b1704 JW1694 aroH 38,735 aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 3-deoxy-7-phosphoheptulonate synthase activity [GO:0003849]; identical protein binding [GO:0042802]; aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] 3-deoxy-7-phosphoheptulonate synthase activity [GO:0003849]; identical protein binding [GO:0042802] GO:0003849; GO:0005737; GO:0008652; GO:0009073; GO:0009423; GO:0042802 +P0ABA0 ATPF_ECOLI ATP synthase subunit b (ATP synthase F(0) sector subunit b) (ATPase subunit I) (F-type ATPase subunit b) (F-ATPase subunit b) atpF papF uncF b3736 JW3714 papF uncF atpF 17,264 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, coupling factor F(o) [GO:0045263]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961] proton-transporting ATPase activity, rotational mechanism [GO:0046961]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933] GO:0005886; GO:0016021; GO:0045263; GO:0046933; GO:0046961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01398}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01398}. +Q06067 ATOS_ECOLI Signal transduction histidine-protein kinase AtoS (EC 2.7.13.3) atoS b2219 JW2213 atoS 67,790 peptidyl-histidine phosphorylation [GO:0018106]; protein autophosphorylation [GO:0046777]; regulation of transcription, DNA-templated [GO:0006355]; response to polyamine macromolecule [GO:1904583]; signal transduction [GO:0007165] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; peptidyl-histidine phosphorylation [GO:0018106]; protein autophosphorylation [GO:0046777]; regulation of transcription, DNA-templated [GO:0006355]; response to polyamine macromolecule [GO:1904583]; signal transduction [GO:0007165] ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155] GO:0000155; GO:0005524; GO:0005886; GO:0006355; GO:0007165; GO:0016021; GO:0018106; GO:0046777; GO:1904583 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:16153782}; Multi-pass membrane protein {ECO:0000255}. +P0ABB8 ATMA_ECOLI Magnesium-transporting ATPase, P-type 1 (EC 7.2.2.14) (Mg(2+) transport ATPase, P-type 1) mgtA corB mgt b4242 JW4201 corB mgt mgtA 99,466 cellular response to magnesium ion [GO:0071286]; magnesium ion transmembrane transport [GO:1903830] integral component of plasma membrane [GO:0005887]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled cation transmembrane transporter activity [GO:0019829]; ion transmembrane transporter activity, phosphorylative mechanism [GO:0015662]; metal ion binding [GO:0046872]; P-type magnesium transporter activity [GO:0015444]; cellular response to magnesium ion [GO:0071286]; magnesium ion transmembrane transport [GO:1903830] ATPase-coupled cation transmembrane transporter activity [GO:0019829]; ATP binding [GO:0005524]; ion transmembrane transporter activity, phosphorylative mechanism [GO:0015662]; metal ion binding [GO:0046872]; P-type magnesium transporter activity [GO:0015444] GO:0005524; GO:0005886; GO:0005887; GO:0015444; GO:0015662; GO:0019829; GO:0043231; GO:0046872; GO:0071286; GO:1903830 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P06609 BTUC_ECOLI Vitamin B12 import system permease protein BtuC btuC b1711 JW1701 btuC 34,949 cobalamin transport [GO:0015889] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ABC-type vitamin B12 transporter activity [GO:0015420]; identical protein binding [GO:0042802]; transmembrane transporter activity [GO:0022857]; cobalamin transport [GO:0015889] ABC-type vitamin B12 transporter activity [GO:0015420]; identical protein binding [GO:0042802]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0015420; GO:0015889; GO:0016020; GO:0022857; GO:0042802; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P30847 BAES_ECOLI Signal transduction histidine-protein kinase BaeS (EC 2.7.13.3) baeS b2078 JW2063 baeS 51,991 cellular response to cell envelope stress [GO:0036460]; protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; cellular response to cell envelope stress [GO:0036460]; protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165] ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155] GO:0000155; GO:0005524; GO:0005886; GO:0005887; GO:0007165; GO:0016020; GO:0036460; GO:0046777 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P07363 CHEA_ECOLI Chemotaxis protein CheA (EC 2.7.13.3) cheA b1888 JW1877 cheA 71,382 aerotaxis [GO:0009454]; chemotaxis [GO:0006935]; establishment of localization in cell [GO:0051649]; negative regulation of protein modification process [GO:0031400]; peptidyl-histidine phosphorylation [GO:0018106]; phosphorelay signal transduction system [GO:0000160]; phosphorylation [GO:0016310]; positive regulation of post-translational protein modification [GO:1901875]; protein autophosphorylation [GO:0046777]; regulation of bacterial-type flagellum-dependent cell motility [GO:1902021]; regulation of chemotaxis [GO:0050920]; signal transduction [GO:0007165]; thermotaxis [GO:0043052] cytoplasm [GO:0005737]; cytosol [GO:0005829]; methyl accepting chemotaxis protein complex [GO:0098561]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; cytosol [GO:0005829]; methyl accepting chemotaxis protein complex [GO:0098561]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673]; aerotaxis [GO:0009454]; chemotaxis [GO:0006935]; establishment of localization in cell [GO:0051649]; negative regulation of protein modification process [GO:0031400]; peptidyl-histidine phosphorylation [GO:0018106]; phosphorelay signal transduction system [GO:0000160]; phosphorylation [GO:0016310]; positive regulation of post-translational protein modification [GO:1901875]; protein autophosphorylation [GO:0046777]; regulation of bacterial-type flagellum-dependent cell motility [GO:1902021]; regulation of chemotaxis [GO:0050920]; signal transduction [GO:0007165]; thermotaxis [GO:0043052] ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673] GO:0000155; GO:0000160; GO:0004673; GO:0005524; GO:0005737; GO:0005829; GO:0005886; GO:0006935; GO:0007165; GO:0009454; GO:0016310; GO:0018106; GO:0031400; GO:0043052; GO:0046777; GO:0050920; GO:0051649; GO:0098561; GO:1901875; GO:1902021 SUBCELLULAR LOCATION: Cytoplasm. +P0A6H1 CLPX_ECOLI ATP-dependent Clp protease ATP-binding subunit ClpX (ATP-dependent unfoldase ClpX) clpX lopC b0438 JW0428 lopC clpX 46,356 cell division [GO:0051301]; protein catabolic process [GO:0030163]; protein denaturation [GO:0030164]; protein folding [GO:0006457]; protein unfolding [GO:0043335]; proteolysis [GO:0006508]; viral process [GO:0016032] cytosol [GO:0005829]; HslUV protease complex [GO:0009376] cytosol [GO:0005829]; HslUV protease complex [GO:0009376]; ATP binding [GO:0005524]; ATP-dependent peptidase activity [GO:0004176]; ATPase activity [GO:0016887]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; protein dimerization activity [GO:0046983]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]; cell division [GO:0051301]; protein catabolic process [GO:0030163]; protein denaturation [GO:0030164]; protein folding [GO:0006457]; protein unfolding [GO:0043335]; proteolysis [GO:0006508]; viral process [GO:0016032] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; ATP-dependent peptidase activity [GO:0004176]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; protein dimerization activity [GO:0046983]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270] GO:0002020; GO:0004176; GO:0005524; GO:0005829; GO:0006457; GO:0006508; GO:0008270; GO:0009376; GO:0016032; GO:0016887; GO:0030163; GO:0030164; GO:0042802; GO:0043335; GO:0046983; GO:0051082; GO:0051301; GO:0097718 +P11071 ACEK_ECOLI Isocitrate dehydrogenase kinase/phosphatase (IDH kinase/phosphatase) (IDHK/P) (EC 2.7.11.5) (EC 3.1.3.-) aceK b4016 JW3976 aceK 67,699 glucose metabolic process [GO:0006006]; glyoxylate cycle [GO:0006097]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-serine phosphorylation [GO:0018105]; protein dephosphorylation [GO:0006470]; regulation of catalytic activity [GO:0050790]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; [isocitrate dehydrogenase (NADP+)] kinase activity [GO:0008772]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine phosphatase activity [GO:0004722]; glucose metabolic process [GO:0006006]; glyoxylate cycle [GO:0006097]; peptidyl-serine dephosphorylation [GO:0070262]; peptidyl-serine phosphorylation [GO:0018105]; protein dephosphorylation [GO:0006470]; regulation of catalytic activity [GO:0050790]; tricarboxylic acid cycle [GO:0006099] [isocitrate dehydrogenase (NADP+)] kinase activity [GO:0008772]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; phosphoprotein phosphatase activity [GO:0004721]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine phosphatase activity [GO:0004722] GO:0004674; GO:0004721; GO:0004722; GO:0005524; GO:0005737; GO:0006006; GO:0006097; GO:0006099; GO:0006470; GO:0008772; GO:0016208; GO:0018105; GO:0050790; GO:0070262 SUBCELLULAR LOCATION: Cytoplasm. +P46854 AAAT_ECOLI L-amino acid N-acetyltransferase AaaT (L-methionine N-acetyltransferase) (EC 2.3.1.-) (L-phenylalanine N-acetyltransferase) (EC 2.3.1.53) aaaT yhhY b3441 JW3405 yhhY aaaT 18,794 methione N-acyltransferase activity [GO:0103045]; N-acetyltransferase activity [GO:0008080]; phenylalanine N-acetyltransferase activity [GO:0050176]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] methione N-acyltransferase activity [GO:0103045]; N-acetyltransferase activity [GO:0008080]; phenylalanine N-acetyltransferase activity [GO:0050176]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] GO:0008080; GO:0016747; GO:0050176; GO:0103045 +P22333 ADD_ECOLI Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) add b1623 JW1615 add 36,397 adenosine catabolic process [GO:0006154]; cellular response to DNA damage stimulus [GO:0006974]; hypoxanthine biosynthetic process [GO:0046101]; hypoxanthine salvage [GO:0043103]; inosine biosynthetic process [GO:0046103]; purine nucleotide interconversion [GO:0015950]; purine nucleotide salvage [GO:0032261]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168] cytosol [GO:0005829] cytosol [GO:0005829]; adenosine deaminase activity [GO:0004000]; zinc ion binding [GO:0008270]; adenosine catabolic process [GO:0006154]; cellular response to DNA damage stimulus [GO:0006974]; hypoxanthine biosynthetic process [GO:0046101]; hypoxanthine salvage [GO:0043103]; inosine biosynthetic process [GO:0046103]; purine nucleotide interconversion [GO:0015950]; purine nucleotide salvage [GO:0032261]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168] adenosine deaminase activity [GO:0004000]; zinc ion binding [GO:0008270] GO:0004000; GO:0005829; GO:0006154; GO:0006974; GO:0008270; GO:0009168; GO:0015950; GO:0032261; GO:0043103; GO:0046101; GO:0046103 +P69681 AMTB_ECOLI Ammonium transporter AmtB (Ammonia channel AmtB) (Ammonium channel AmtB) amtB ybaG b0451 JW0441 ybaG amtB 44,515 ammonium transport [GO:0015696]; carbon dioxide transport [GO:0015670]; nitrogen utilization [GO:0019740] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ammonium transmembrane transporter activity [GO:0008519]; identical protein binding [GO:0042802]; uniporter activity [GO:0015292]; ammonium transport [GO:0015696]; carbon dioxide transport [GO:0015670]; nitrogen utilization [GO:0019740] ammonium transmembrane transporter activity [GO:0008519]; identical protein binding [GO:0042802]; uniporter activity [GO:0015292] GO:0005886; GO:0005887; GO:0008519; GO:0015292; GO:0015670; GO:0015696; GO:0019740; GO:0042802 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:11847102, ECO:0000269|PubMed:12023896, ECO:0000269|PubMed:15361618, ECO:0000269|PubMed:15563598, ECO:0000269|PubMed:17040913}; Multi-pass membrane protein {ECO:0000269|PubMed:15361618, ECO:0000269|PubMed:15563598, ECO:0000269|PubMed:17040913}. +P30860 ARTJ_ECOLI ABC transporter arginine-binding protein 1 artJ b0860 JW0844 artJ 26,829 arginine transport [GO:0015809]; L-arginine import across plasma membrane [GO:0097638] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; amino acid binding [GO:0016597]; arginine binding [GO:0034618]; ligand-gated ion channel activity [GO:0015276]; arginine transport [GO:0015809]; L-arginine import across plasma membrane [GO:0097638] amino acid binding [GO:0016597]; arginine binding [GO:0034618]; ligand-gated ion channel activity [GO:0015276] GO:0015276; GO:0015809; GO:0016020; GO:0016597; GO:0030288; GO:0034618; GO:0042597; GO:0097638 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:8801422}. +P63284 CLPB_ECOLI Chaperone protein ClpB (Heat shock protein F84.1) clpB htpM b2592 JW2573 htpM clpB 95,585 cellular response to heat [GO:0034605]; protein refolding [GO:0042026]; response to heat [GO:0009408] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; identical protein binding [GO:0042802]; cellular response to heat [GO:0034605]; protein refolding [GO:0042026]; response to heat [GO:0009408] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; identical protein binding [GO:0042802] GO:0005524; GO:0005737; GO:0005829; GO:0009408; GO:0016020; GO:0016887; GO:0034605; GO:0042026; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8376377}. +P0A6N4 EFP_ECOLI Elongation factor P (EF-P) efp b4147 JW4107 efp 20,591 negative regulation of translational frameshifting [GO:2001125]; rescue of stalled ribosome [GO:0072344]; translational elongation [GO:0006414] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribosome binding [GO:0043022]; translation elongation factor activity [GO:0003746]; negative regulation of translational frameshifting [GO:2001125]; rescue of stalled ribosome [GO:0072344]; translational elongation [GO:0006414] ribosome binding [GO:0043022]; translation elongation factor activity [GO:0003746] GO:0003746; GO:0005737; GO:0005829; GO:0006414; GO:0043022; GO:0072344; GO:2001125 SUBCELLULAR LOCATION: Cytoplasm. +P29680 DCUP_ECOLI Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37) hemE b3997 JW3961 hemE 39,248 heme biosynthetic process [GO:0006783]; porphyrin-containing compound biosynthetic process [GO:0006779]; protoporphyrinogen IX biosynthetic process from glutamate [GO:0019353]; uroporphyrinogen III biosynthetic process [GO:0006780] cytosol [GO:0005829] cytosol [GO:0005829]; uroporphyrinogen decarboxylase activity [GO:0004853]; heme biosynthetic process [GO:0006783]; porphyrin-containing compound biosynthetic process [GO:0006779]; protoporphyrinogen IX biosynthetic process from glutamate [GO:0019353]; uroporphyrinogen III biosynthetic process [GO:0006780] uroporphyrinogen decarboxylase activity [GO:0004853] GO:0004853; GO:0005829; GO:0006779; GO:0006780; GO:0006783; GO:0019353 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00218}. +P0AA76 DGOT_ECOLI D-galactonate transporter dgoT yidT b3691 JW5859 yidT dgoT 47,077 D-galactonate catabolic process [GO:0034194]; D-galactonate transmembrane transport [GO:0042875] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; D-galactonate transmembrane transporter activity [GO:0042881]; solute:proton symporter activity [GO:0015295]; D-galactonate catabolic process [GO:0034194]; D-galactonate transmembrane transport [GO:0042875] D-galactonate transmembrane transporter activity [GO:0042881]; solute:proton symporter activity [GO:0015295] GO:0005886; GO:0005887; GO:0015295; GO:0034194; GO:0042875; GO:0042881 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76147 DGCF_ECOLI Probable diguanylate cyclase DgcF (DGC) (EC 2.7.7.65) dgcF yneF b1522 JW5825 yneF dgcF 34,322 cell adhesion involved in single-species biofilm formation [GO:0043709]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201]; regulation of bacterial-type flagellum-dependent cell motility [GO:1902021] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; cell adhesion involved in single-species biofilm formation [GO:0043709]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201]; regulation of bacterial-type flagellum-dependent cell motility [GO:1902021] diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872] GO:0005525; GO:0005886; GO:0016021; GO:0043709; GO:0046872; GO:0052621; GO:1902021; GO:1902201 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P0AC73 EBGC_ECOLI Evolved beta-galactosidase subunit beta ebgC b3077 JW3048 ebgC 17,457 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P0AA86 DSBE_ECOLI Thiol:disulfide interchange protein DsbE (Cytochrome c biogenesis protein CcmG) dsbE ccmG yejQ b2195 JW2183 ccmG yejQ dsbE 20,809 cytochrome complex assembly [GO:0017004] integral component of membrane [GO:0016021]; intrinsic component of periplasmic side of plasma membrane [GO:0031237]; outer membrane-bounded periplasmic space [GO:0030288] integral component of membrane [GO:0016021]; intrinsic component of periplasmic side of plasma membrane [GO:0031237]; outer membrane-bounded periplasmic space [GO:0030288]; disulfide oxidoreductase activity [GO:0015036]; cytochrome complex assembly [GO:0017004] disulfide oxidoreductase activity [GO:0015036] GO:0015036; GO:0016021; GO:0017004; GO:0030288; GO:0031237 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein; Periplasmic side. +P76297 FLHE_ECOLI Flagellar protein FlhE flhE b1878 JW1867 flhE 14,059 bacterial-type flagellum organization [GO:0044781] bacterial-type flagellum [GO:0009288] bacterial-type flagellum [GO:0009288]; bacterial-type flagellum organization [GO:0044781] GO:0009288; GO:0044781 +P32177 FDHD_ECOLI Sulfur carrier protein FdhD (Sulfurtransferase FdhD) fdhD b3895 JW3866 fdhD 30,560 Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; positive regulation of catalytic activity [GO:0043085] cytosol [GO:0005829] cytosol [GO:0005829]; molybdopterin cofactor binding [GO:0043546]; sulfur carrier activity [GO:0097163]; sulfurtransferase activity [GO:0016783]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; positive regulation of catalytic activity [GO:0043085] molybdopterin cofactor binding [GO:0043546]; sulfur carrier activity [GO:0097163]; sulfurtransferase activity [GO:0016783] GO:0005829; GO:0006777; GO:0016783; GO:0043085; GO:0043546; GO:0097163 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187, ECO:0000269|PubMed:2170340}. +P68644 FIXC_ECOLI Protein FixC fixC yaaS b0043 JW0042 yaaS fixC 45,703 carnitine metabolic process [GO:0009437] FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; carnitine metabolic process [GO:0009437] FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491] GO:0009437; GO:0016491; GO:0071949 +P0AEK7 FDNI_ECOLI Formate dehydrogenase, nitrate-inducible, cytochrome b556(Fdn) subunit (Anaerobic formate dehydrogenase cytochrome b556 subunit) (Formate dehydrogenase-N subunit gamma) (FDH-N subunit gamma) fdnI b1476 JW1472 fdnI 25,368 anaerobic respiration [GO:0009061]; formate oxidation [GO:0015944]; respiratory electron transport chain [GO:0022904] formate dehydrogenase complex [GO:0009326]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] formate dehydrogenase complex [GO:0009326]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; formate dehydrogenase (NAD+) activity [GO:0008863]; formate dehydrogenase (quinone) activity [GO:0036397]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; anaerobic respiration [GO:0009061]; formate oxidation [GO:0015944]; respiratory electron transport chain [GO:0022904] electron transfer activity [GO:0009055]; formate dehydrogenase (NAD+) activity [GO:0008863]; formate dehydrogenase (quinone) activity [GO:0036397]; heme binding [GO:0020037]; metal ion binding [GO:0046872] GO:0005886; GO:0005887; GO:0008863; GO:0009055; GO:0009061; GO:0009326; GO:0015944; GO:0016021; GO:0020037; GO:0022904; GO:0036397; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:11884747}; Multi-pass membrane protein {ECO:0000269|PubMed:11884747}. +P24180 ACRE_ECOLI Multidrug export protein AcrE (Acriflavine resistance protein E) (Protein EnvC) acrE envC b3265 JW3233 envC acrE 41,318 response to antibiotic [GO:0046677]; response to drug [GO:0042493] intrinsic component of plasma membrane [GO:0031226] intrinsic component of plasma membrane [GO:0031226]; xenobiotic transmembrane transporter activity [GO:0042910]; response to antibiotic [GO:0046677]; response to drug [GO:0042493] xenobiotic transmembrane transporter activity [GO:0042910] GO:0031226; GO:0042493; GO:0042910; GO:0046677 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:11274125}; Lipid-anchor {ECO:0000305|PubMed:11274125}. +P37655 BCSQP_ECOLI Putative cellulose biosynthesis protein BcsQ bcsQ yhjQ b3534 yhjQ bcsQ 27,140 negative regulation of cell division [GO:0051782] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829] cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; negative regulation of cell division [GO:0051782] ATPase activity [GO:0016887]; ATP binding [GO:0005524] GO:0005524; GO:0005829; GO:0009898; GO:0016887; GO:0051782 +P0ABE2 BOLA_ECOLI DNA-binding transcriptional regulator BolA bolA b0435 JW5060 bolA 11,994 transcription, DNA-templated [GO:0006351] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677] GO:0003677; GO:0005829; GO:0006351 +P07330 CHEB_ECOLI Protein-glutamate methylesterase/protein-glutamine glutaminase (EC 3.1.1.61) (EC 3.5.1.44) (Chemotaxis response regulator protein-glutamate methylesterase/glutamine deamidase) (Methyl-accepting chemotaxis proteins-specific methylesterase/deamidase) (MCP-specific methylesterase/deamidase) cheB b1883 JW1872 cheB 37,468 chemotaxis [GO:0006935]; protein deamination [GO:0018277]; protein demethylation [GO:0006482]; signal transduction [GO:0007165] cytosol [GO:0005829]; plasma membrane [GO:0005886] cytosol [GO:0005829]; plasma membrane [GO:0005886]; deaminase binding [GO:1990827]; phosphorelay response regulator activity [GO:0000156]; protein-glutamate methylesterase activity [GO:0008984]; protein-glutamine glutaminase activity [GO:0050568]; chemotaxis [GO:0006935]; protein deamination [GO:0018277]; protein demethylation [GO:0006482]; signal transduction [GO:0007165] deaminase binding [GO:1990827]; phosphorelay response regulator activity [GO:0000156]; protein-glutamate methylesterase activity [GO:0008984]; protein-glutamine glutaminase activity [GO:0050568] GO:0000156; GO:0005829; GO:0005886; GO:0006482; GO:0006935; GO:0007165; GO:0008984; GO:0018277; GO:0050568; GO:1990827 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00099, ECO:0000269|PubMed:358191}. +P0A6F5 CH60_ECOLI 60 kDa chaperonin (GroEL protein) (Protein Cpn60) groL groEL mopA b4143 JW4103 groEL mopA groL 57,329 cell cycle [GO:0007049]; cell division [GO:0051301]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein folding [GO:0006457]; protein refolding [GO:0042026]; response to heat [GO:0009408]; response to radiation [GO:0009314]; virion assembly [GO:0019068] cytosol [GO:0005829]; GroEL-GroES complex [GO:1990220]; membrane [GO:0016020] cytosol [GO:0005829]; GroEL-GroES complex [GO:1990220]; membrane [GO:0016020]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; unfolded protein binding [GO:0051082]; cell cycle [GO:0007049]; cell division [GO:0051301]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein folding [GO:0006457]; protein refolding [GO:0042026]; response to heat [GO:0009408]; response to radiation [GO:0009314]; virion assembly [GO:0019068] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; unfolded protein binding [GO:0051082] GO:0000287; GO:0005524; GO:0005829; GO:0006457; GO:0007049; GO:0009314; GO:0009408; GO:0016020; GO:0016887; GO:0019068; GO:0042026; GO:0042802; GO:0051082; GO:0051085; GO:0051301; GO:1990220 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00600, ECO:0000269|PubMed:20094032, ECO:0000269|PubMed:22380631}. Note=Uniformly located in the cytoplasm (PubMed:20094032). Exclusively localized in foci, usually near 1 cell pole in mid-to-late exponential phase (PubMed:22380631); polar localization depends on the minCDE operon. Foci form near midcell (Probable). {ECO:0000269|PubMed:20094032, ECO:0000269|PubMed:22380631, ECO:0000305}. +P0A9H7 CFA_ECOLI Cyclopropane-fatty-acyl-phospholipid synthase (CFA synthase) (Cyclopropane fatty acid synthase) (EC 2.1.1.79) cfa cdfA b1661 JW1653 cdfA cfa 43,909 fatty acid biosynthetic process [GO:0006633]; lipid modification [GO:0030258]; methylation [GO:0032259] cytosol [GO:0005829] cytosol [GO:0005829]; bicarbonate binding [GO:0071890]; cyclopropane-fatty-acyl-phospholipid synthase activity [GO:0008825]; fatty acid biosynthetic process [GO:0006633]; lipid modification [GO:0030258]; methylation [GO:0032259] bicarbonate binding [GO:0071890]; cyclopropane-fatty-acyl-phospholipid synthase activity [GO:0008825] GO:0005829; GO:0006633; GO:0008825; GO:0030258; GO:0032259; GO:0071890 SUBCELLULAR LOCATION: Cytoplasm. +P0A6I3 COAA_ECOLI Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase) (Rts protein) coaA panK rts b3974 JW3942 panK rts coaA 36,360 coenzyme A biosynthetic process [GO:0015937] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; pantetheine kinase activity [GO:0050165]; pantothenate kinase activity [GO:0004594]; coenzyme A biosynthetic process [GO:0015937] ATP binding [GO:0005524]; pantetheine kinase activity [GO:0050165]; pantothenate kinase activity [GO:0004594] GO:0004594; GO:0005524; GO:0005737; GO:0015937; GO:0050165 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0ABR7 CNTA_ECOLI Carnitine monooxygenase oxygenase subunit (EC 1.14.13.239) (Carnitine monooxygenase alpha subunit) yeaW b1802 JW5294 yeaW 42,561 carnitine metabolic process [GO:0009437] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; 2 iron, 2 sulfur cluster binding [GO:0051537]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; carnitine metabolic process [GO:0009437] 2 iron, 2 sulfur cluster binding [GO:0051537]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709] GO:0005506; GO:0009437; GO:0016709; GO:0032991; GO:0042802; GO:0051537 +P0A988 DPO3B_ECOLI Beta sliding clamp (Beta clamp) (Sliding clamp) (Beta-clamp processivity factor) (DNA polymerase III beta sliding clamp subunit) dnaN b3701 JW3678 dnaN 40,587 bacterial-type DNA replication [GO:0044787]; cellular response to DNA damage stimulus [GO:0006974]; DNA strand elongation involved in DNA replication [GO:0006271]; error-prone translesion synthesis [GO:0042276] cytosol [GO:0005829]; DNA polymerase III complex [GO:0009360] cytosol [GO:0005829]; DNA polymerase III complex [GO:0009360]; 3'-5' exonuclease activity [GO:0008408]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; identical protein binding [GO:0042802]; bacterial-type DNA replication [GO:0044787]; cellular response to DNA damage stimulus [GO:0006974]; DNA strand elongation involved in DNA replication [GO:0006271]; error-prone translesion synthesis [GO:0042276] 3'-5' exonuclease activity [GO:0008408]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; identical protein binding [GO:0042802] GO:0003677; GO:0003887; GO:0005829; GO:0006271; GO:0006974; GO:0008408; GO:0009360; GO:0042276; GO:0042802; GO:0044787 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23994470}. Note=Localizes to midcell position when chromosomes are condensed during DNA replication (PubMed:23994470). {ECO:0000269|PubMed:23994470}. +P36995 CSPB_ECOLI Cold shock-like protein CspB (CSP-B) cspB b1557 JW1549 cspB 7,717 negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468]; response to cold [GO:0009409] cytosol [GO:0005829] cytosol [GO:0005829]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; transcription antitermination factor activity, RNA binding [GO:0001072]; negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468]; response to cold [GO:0009409] nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; transcription antitermination factor activity, RNA binding [GO:0001072] GO:0001072; GO:0003676; GO:0003697; GO:0003723; GO:0005829; GO:0009409; GO:0010468; GO:0060567 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P0A9Y6 CSPC_ECOLI Cold shock-like protein CspC (CSP-C) cspC msmB b1823 JW1812 msmB cspC 7,402 negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; chaperone binding [GO:0051087]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; transcription antitermination factor activity, RNA binding [GO:0001072]; negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468] chaperone binding [GO:0051087]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; transcription antitermination factor activity, RNA binding [GO:0001072] GO:0001072; GO:0003676; GO:0003697; GO:0003723; GO:0005829; GO:0010468; GO:0016020; GO:0051087; GO:0060567 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P54901 CSIE_ECOLI Stationary phase-inducible protein CsiE csiE b2535 JW5878 csiE 49,040 regulation of transcription, DNA-templated [GO:0006355] regulation of transcription, DNA-templated [GO:0006355] GO:0006355 +P39099 DEGQ_ECOLI Periplasmic pH-dependent serine endoprotease DegQ (EC 3.4.21.107) (Protease Do) degQ hhoA b3234 JW3203 hhoA degQ 47,205 proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603] integral component of external side of plasma membrane [GO:0071575]; periplasmic space [GO:0042597] integral component of external side of plasma membrane [GO:0071575]; periplasmic space [GO:0042597]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603] identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] GO:0004252; GO:0006508; GO:0008233; GO:0042597; GO:0042802; GO:0051603; GO:0071575 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:8576051}. +P75856 ELFD_ECOLI Probable fimbrial chaperone protein ElfD elfD ycbR b0939 JW0922 ycbR elfD 25,389 cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] GO:0030288; GO:0043711; GO:0061077; GO:0071555 SUBCELLULAR LOCATION: Periplasm {ECO:0000250}. +P10805 ENVY_ECOLI Porin thermoregulatory protein EnvY envY b0566 JW0555 envY 29,019 response to temperature stimulus [GO:0009266] membrane [GO:0016020] membrane [GO:0016020]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; response to temperature stimulus [GO:0009266] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0009266; GO:0016020; GO:0043565 +P09030 EX3_ECOLI Exodeoxyribonuclease III (EXO III) (Exonuclease III) (EC 3.1.11.2) (AP endonuclease VI) xthA xth b1749 JW1738 xth xthA 30,969 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; exodeoxyribonuclease III activity [GO:0008853]; exonuclease activity [GO:0004527]; metal ion binding [GO:0046872]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281] DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; exodeoxyribonuclease III activity [GO:0008853]; exonuclease activity [GO:0004527]; metal ion binding [GO:0046872] GO:0003677; GO:0004519; GO:0004527; GO:0005829; GO:0006281; GO:0006974; GO:0008853; GO:0046872 +P77712 FADM_ECOLI Long-chain acyl-CoA thioesterase FadM (EC 3.1.2.-) (Acyl-CoA thioester hydrolase) (Thioesterase 3) (Thioesterase III) fadM tesC ybaW b0443 JW0433 tesC ybaW fadM 15,088 fatty acid beta-oxidation [GO:0006635] acyl-CoA hydrolase activity [GO:0047617]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; fatty acid beta-oxidation [GO:0006635] acyl-CoA hydrolase activity [GO:0047617]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290] GO:0006635; GO:0016290; GO:0047617; GO:0102991 +P05523 FPG_ECOLI Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18) mutM fpg b3635 JW3610 fpg mutM 30,290 base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; cellular response to DNA damage stimulus [GO:0006974] 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity [GO:0034039]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; oxidized purine nucleobase lesion DNA N-glycosylase activity [GO:0008534]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]; zinc ion binding [GO:0008270]; base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; cellular response to DNA damage stimulus [GO:0006974] 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity [GO:0034039]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; DNA N-glycosylase activity [GO:0019104]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; oxidized purine nucleobase lesion DNA N-glycosylase activity [GO:0008534]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]; zinc ion binding [GO:0008270] GO:0000703; GO:0003684; GO:0003906; GO:0004519; GO:0006284; GO:0006285; GO:0006974; GO:0008270; GO:0008534; GO:0019104; GO:0034039; GO:0046872; GO:0140078 +P04825 AMPN_ECOLI Aminopeptidase N (EC 3.4.11.2) (Alpha-aminoacylpeptide hydrolase) pepN b0932 JW0915 pepN 98,919 proteolysis [GO:0006508] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; aminopeptidase activity [GO:0004177]; identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; proteolysis [GO:0006508] aminopeptidase activity [GO:0004177]; identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270] GO:0004177; GO:0005886; GO:0006508; GO:0008237; GO:0008270; GO:0042802 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. +P0AE34 ARTQ_ECOLI Arginine ABC transporter permease protein ArtQ artQ b0862 JW0846 artQ 26,217 L-arginine import across plasma membrane [GO:0097638] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; L-arginine import across plasma membrane [GO:0097638] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0022857; GO:0043190; GO:0097638 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P37659 BCSG_ECOLI Cellulose biosynthesis protein BcsG bcsG yhjU b3538 JW3506 yhjU bcsG 62,032 cellulose biosynthetic process [GO:0030244] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; catalytic activity [GO:0003824]; cellulose biosynthetic process [GO:0030244] catalytic activity [GO:0003824] GO:0003824; GO:0005886; GO:0016021; GO:0030244 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0ABE5 C561_ECOLI Cytochrome b561 (Cytochrome b-561) cybB b1418 JW5224 cybB 20,286 removal of superoxide radicals [GO:0019430]; respiratory electron transport chain [GO:0022904] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; removal of superoxide radicals [GO:0019430]; respiratory electron transport chain [GO:0022904] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872] GO:0005886; GO:0005887; GO:0009055; GO:0019430; GO:0020037; GO:0022904; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P75734 CHIQ_ECOLI Uncharacterized lipoprotein ChiQ chiQ ybfN b0682 JW0668 ybfN chiQ 11,999 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:12876315}; Lipid-anchor {ECO:0000305|PubMed:12876315}. +P08369 CRED_ECOLI Inner membrane protein CreD creD cet b4400 JW4363 cet creD 49,830 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76113 CURA_ECOLI NADPH-dependent curcumin reductase (EC 1.3.1.n3) (NADPH-dependent curcumin/dihydrocurcumin reductase) curA yncB b1449 JW5907 yncB curA 37,610 oxidoreductase activity [GO:0016491] oxidoreductase activity [GO:0016491] GO:0016491 +P69910 DCEB_ECOLI Glutamate decarboxylase beta (GAD-beta) (EC 4.1.1.15) gadB b1493 JW1488 gadB 52,668 glutamate catabolic process [GO:0006538]; intracellular pH elevation [GO:0051454] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; glutamate decarboxylase activity [GO:0004351]; pyridoxal phosphate binding [GO:0030170]; glutamate catabolic process [GO:0006538]; intracellular pH elevation [GO:0051454] glutamate decarboxylase activity [GO:0004351]; pyridoxal phosphate binding [GO:0030170] GO:0004351; GO:0005829; GO:0006538; GO:0016020; GO:0030170; GO:0051454 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12912902}. Membrane {ECO:0000269|PubMed:12912902}. Note=Localized exclusively in the cytoplasm at neutral pH, but is recruited to the membrane when the pH falls. +P0AEE8 DMA_ECOLI DNA adenine methylase (EC 2.1.1.72) (DNA adenine methyltransferase) (Deoxyadenosyl-methyltransferase) (M.EcoDam) dam b3387 JW3350 dam 32,100 bacterial-type DNA replication initiation [GO:1902328]; DNA-dependent DNA replication [GO:0006261]; DNA methylation on adenine [GO:0032775]; mismatch repair [GO:0006298]; response to UV [GO:0009411] S-adenosyl-L-methionine binding [GO:1904047]; sequence-specific DNA binding [GO:0043565]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007]; bacterial-type DNA replication initiation [GO:1902328]; DNA methylation on adenine [GO:0032775]; DNA-dependent DNA replication [GO:0006261]; mismatch repair [GO:0006298]; response to UV [GO:0009411] S-adenosyl-L-methionine binding [GO:1904047]; sequence-specific DNA binding [GO:0043565]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007] GO:0006261; GO:0006298; GO:0009007; GO:0009411; GO:0032775; GO:0043565; GO:1902328; GO:1904047 +P0A9Q9 DHAS_ECOLI Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH) (EC 1.2.1.11) (Aspartate-beta-semialdehyde dehydrogenase) asd hom b3433 JW3396 hom asd 40,018 'de novo' L-methionine biosynthetic process [GO:0071266]; cellular response to DNA damage stimulus [GO:0006974]; diaminopimelate biosynthetic process [GO:0019877]; homoserine biosynthetic process [GO:0009090]; isoleucine biosynthetic process [GO:0009097]; lysine biosynthetic process via diaminopimelate [GO:0009089]; threonine biosynthetic process [GO:0009088] cytosol [GO:0005829] cytosol [GO:0005829]; aspartate-semialdehyde dehydrogenase activity [GO:0004073]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; protein dimerization activity [GO:0046983]; 'de novo' L-methionine biosynthetic process [GO:0071266]; cellular response to DNA damage stimulus [GO:0006974]; diaminopimelate biosynthetic process [GO:0019877]; homoserine biosynthetic process [GO:0009090]; isoleucine biosynthetic process [GO:0009097]; lysine biosynthetic process via diaminopimelate [GO:0009089]; threonine biosynthetic process [GO:0009088] aspartate-semialdehyde dehydrogenase activity [GO:0004073]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; protein dimerization activity [GO:0046983] GO:0004073; GO:0005829; GO:0006974; GO:0009088; GO:0009089; GO:0009090; GO:0009097; GO:0019877; GO:0046983; GO:0050661; GO:0051287; GO:0071266 +P75801 DGCI_ECOLI Probable diguanylate cyclase DgcI (DGC) (EC 2.7.7.65) (Putative lipoprotein DgcI) dgcI yliF b0834 JW0818 yliF dgcI 49,873 cell adhesion involved in single-species biofilm formation [GO:0043709]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; cell adhesion involved in single-species biofilm formation [GO:0043709]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201] diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872] GO:0005525; GO:0005886; GO:0016021; GO:0043709; GO:0046872; GO:0052621; GO:1902201 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P33371 DUSC_ECOLI tRNA-dihydrouridine(16) synthase (EC 1.3.1.-) (U16-specific dihydrouridine synthase) (U16-specific Dus) (tRNA-dihydrouridine synthase C) dusC yohI b2140 JW2128 yohI dusC 35,199 tRNA dihydrouridine synthesis [GO:0002943] flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; tRNA binding [GO:0000049]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA dihydrouridine synthesis [GO:0002943] flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; tRNA binding [GO:0000049]; tRNA dihydrouridine synthase activity [GO:0017150] GO:0000049; GO:0002943; GO:0010181; GO:0017150; GO:0050660 +P06136 FTSQ_ECOLI Cell division protein FtsQ ftsQ b0093 JW0091 ftsQ 31,434 cell division [GO:0051301]; division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093] cell division site [GO:0032153]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cell division site [GO:0032153]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; cell division [GO:0051301]; division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093] identical protein binding [GO:0042802] GO:0000917; GO:0005886; GO:0005887; GO:0016021; GO:0032153; GO:0042802; GO:0043093; GO:0051301 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00911, ECO:0000269|PubMed:11415986, ECO:0000269|PubMed:11703663, ECO:0000269|PubMed:11948172, ECO:0000269|PubMed:15165235, ECO:0000269|PubMed:17693520, ECO:0000269|PubMed:2007547, ECO:0000269|PubMed:9829918, ECO:0000269|PubMed:9882666}; Single-pass type II membrane protein {ECO:0000255|HAMAP-Rule:MF_00911, ECO:0000269|PubMed:11415986, ECO:0000269|PubMed:11703663, ECO:0000269|PubMed:11948172, ECO:0000269|PubMed:15165235, ECO:0000269|PubMed:17693520, ECO:0000269|PubMed:2007547, ECO:0000269|PubMed:9829918, ECO:0000269|PubMed:9882666}. Note=Localizes to the division septum. Localization requires FtsZ, FtsA, ZipA and FtsK, but not FtsL, FtsI and FtsN. Insertion into the membrane requires YidC and the Sec translocase. +P45565 AIS_ECOLI Lipopolysaccharide core heptose(II)-phosphate phosphatase (EC 3.1.3.-) (Polymyxin resistance protein PmrG) ais pmrG b2252 JW2246 pmrG ais 22,257 lipopolysaccharide metabolic process [GO:0008653] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; phosphatase activity [GO:0016791]; lipopolysaccharide metabolic process [GO:0008653] phosphatase activity [GO:0016791] GO:0008653; GO:0016791; GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000250}. +P0A955 ALKH_ECOLI KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) (2-keto-4-hydroxyglutarate aldolase) (KHG-aldolase); 2-dehydro-3-deoxy-phosphogluconate aldolase (EC 4.1.2.14) (2-keto-3-deoxy-6-phosphogluconate aldolase) (KDPG-aldolase) (Phospho-2-dehydro-3-deoxygluconate aldolase) (Phospho-2-keto-3-deoxygluconate aldolase)] eda hga kdgA b1850 JW1839 hga kdgA eda 22,284 metabolic process [GO:0008152] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; (4S)-4-hydroxy-2-oxoglutarate aldolase activity [GO:0106009]; 2-dehydro-3-deoxy-phosphogluconate aldolase activity [GO:0008675]; 4-hydroxy-2-oxoglutarate aldolase activity [GO:0008700]; identical protein binding [GO:0042802]; oxaloacetate decarboxylase activity [GO:0008948]; oxo-acid-lyase activity [GO:0016833]; metabolic process [GO:0008152] (4S)-4-hydroxy-2-oxoglutarate aldolase activity [GO:0106009]; 2-dehydro-3-deoxy-phosphogluconate aldolase activity [GO:0008675]; 4-hydroxy-2-oxoglutarate aldolase activity [GO:0008700]; identical protein binding [GO:0042802]; oxaloacetate decarboxylase activity [GO:0008948]; oxo-acid-lyase activity [GO:0016833] GO:0005829; GO:0008152; GO:0008675; GO:0008700; GO:0008948; GO:0016020; GO:0016833; GO:0042802; GO:0106009 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P18335 ARGD_ECOLI Acetylornithine/succinyldiaminopimelate aminotransferase (ACOAT) (DapATase) (Succinyldiaminopimelate transferase) (EC 2.6.1.11) (EC 2.6.1.17) argD dapC dtu b3359 JW3322 dapC dtu argD 43,767 arginine biosynthetic process via ornithine [GO:0042450]; lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate [GO:0033359] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity [GO:0003992]; pyridoxal phosphate binding [GO:0030170]; succinyldiaminopimelate transaminase activity [GO:0009016]; arginine biosynthetic process via ornithine [GO:0042450]; lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate [GO:0033359] identical protein binding [GO:0042802]; N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity [GO:0003992]; pyridoxal phosphate binding [GO:0030170]; succinyldiaminopimelate transaminase activity [GO:0009016] GO:0003992; GO:0005737; GO:0009016; GO:0030170; GO:0033359; GO:0042450; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01107, ECO:0000305}. +P0AE67 CHEY_ECOLI Chemotaxis protein CheY cheY b1882 JW1871 cheY 14,097 aerotaxis [GO:0009454]; archaeal or bacterial-type flagellum-dependent cell motility [GO:0097588]; chemotaxis [GO:0006935]; internal peptidyl-lysine acetylation [GO:0018393]; protein acetylation [GO:0006473]; regulation of bacterial-type flagellum-dependent cell motility [GO:1902021]; signal transduction [GO:0007165]; thermotaxis [GO:0043052] cytosol [GO:0005829] cytosol [GO:0005829]; acetyltransferase activity [GO:0016407]; magnesium ion binding [GO:0000287]; phosphorelay response regulator activity [GO:0000156]; aerotaxis [GO:0009454]; archaeal or bacterial-type flagellum-dependent cell motility [GO:0097588]; chemotaxis [GO:0006935]; internal peptidyl-lysine acetylation [GO:0018393]; protein acetylation [GO:0006473]; regulation of bacterial-type flagellum-dependent cell motility [GO:1902021]; signal transduction [GO:0007165]; thermotaxis [GO:0043052] acetyltransferase activity [GO:0016407]; magnesium ion binding [GO:0000287]; phosphorelay response regulator activity [GO:0000156] GO:0000156; GO:0000287; GO:0005829; GO:0006473; GO:0006935; GO:0007165; GO:0009454; GO:0016407; GO:0018393; GO:0043052; GO:0097588; GO:1902021 SUBCELLULAR LOCATION: Cytoplasm. +P0ABJ3 CYOC_ECOLI Cytochrome bo(3) ubiquinol oxidase subunit 3 (Cytochrome o ubiquinol oxidase subunit 3) (Cytochrome o subunit 3) (Oxidase bo(3) subunit 3) (Ubiquinol oxidase chain C) (Ubiquinol oxidase polypeptide III) (Ubiquinol oxidase subunit 3) cyoC b0430 JW0420 cyoC 22,623 aerobic electron transport chain [GO:0019646]; aerobic respiration [GO:0009060]; electron transport coupled proton transport [GO:0015990] cytochrome o ubiquinol oxidase complex [GO:0009319]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cytochrome o ubiquinol oxidase complex [GO:0009319]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cytochrome bo3 ubiquinol oxidase activity [GO:0009486]; cytochrome o ubiquinol oxidase activity [GO:0008827]; cytochrome-c oxidase activity [GO:0004129]; electron transfer activity [GO:0009055]; oxidoreduction-driven active transmembrane transporter activity [GO:0015453]; proton transmembrane transporter activity [GO:0015078]; aerobic electron transport chain [GO:0019646]; aerobic respiration [GO:0009060]; electron transport coupled proton transport [GO:0015990] cytochrome bo3 ubiquinol oxidase activity [GO:0009486]; cytochrome-c oxidase activity [GO:0004129]; cytochrome o ubiquinol oxidase activity [GO:0008827]; electron transfer activity [GO:0009055]; oxidoreduction-driven active transmembrane transporter activity [GO:0015453]; proton transmembrane transporter activity [GO:0015078] GO:0004129; GO:0005886; GO:0005887; GO:0008827; GO:0009055; GO:0009060; GO:0009319; GO:0009486; GO:0015078; GO:0015453; GO:0015990; GO:0019646 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P04036 DAPB_ECOLI 4-hydroxy-tetrahydrodipicolinate reductase (HTPA reductase) (EC 1.17.1.8) dapB b0031 JW0029 dapB 28,757 cellular amino acid biosynthetic process [GO:0008652]; diaminopimelate biosynthetic process [GO:0019877]; lysine biosynthetic process via diaminopimelate [GO:0009089] cytosol [GO:0005829] cytosol [GO:0005829]; 4-hydroxy-tetrahydrodipicolinate reductase [GO:0008839]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [GO:0016726]; cellular amino acid biosynthetic process [GO:0008652]; diaminopimelate biosynthetic process [GO:0019877]; lysine biosynthetic process via diaminopimelate [GO:0009089] 4-hydroxy-tetrahydrodipicolinate reductase [GO:0008839]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [GO:0016726] GO:0005829; GO:0008652; GO:0008839; GO:0009089; GO:0016726; GO:0019877; GO:0042802; GO:0050661; GO:0051287 SUBCELLULAR LOCATION: Cytoplasm. +P15877 DHG_ECOLI Quinoprotein glucose dehydrogenase (EC 1.1.5.2) (Glucose dehydrogenase [pyrroloquinoline-quinone]) gcd b0124 JW0120 gcd 86,747 integral component of membrane [GO:0016021]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; magnesium ion binding [GO:0000287]; pyrroloquinoline quinone binding [GO:0070968]; quinoprotein glucose dehydrogenase activity [GO:0008876]; ubiquinone binding [GO:0048039] magnesium ion binding [GO:0000287]; pyrroloquinoline quinone binding [GO:0070968]; quinoprotein glucose dehydrogenase activity [GO:0008876]; ubiquinone binding [GO:0048039] GO:0000287; GO:0005886; GO:0008876; GO:0016021; GO:0030288; GO:0048039; GO:0070968 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:16079137}; Periplasmic side {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:16079137}. +P0A6P9 ENO_ECOLI Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) eno b2779 JW2750 eno 45,655 glycolytic process [GO:0006096]; regulation of vacuole fusion, non-autophagic [GO:0032889] cell surface [GO:0009986]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; phosphopyruvate hydratase complex [GO:0000015] cell surface [GO:0009986]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; phosphopyruvate hydratase complex [GO:0000015]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634]; glycolytic process [GO:0006096]; regulation of vacuole fusion, non-autophagic [GO:0032889] identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634] GO:0000015; GO:0000287; GO:0004634; GO:0005576; GO:0005829; GO:0005856; GO:0006096; GO:0009986; GO:0016020; GO:0032889; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. As part of the bacterial cytoskeleton in the cytoplasm, is organized as extended coiled structures that wind around the cell, from one cell pole to the other. When covalently bound to the substrate at Lys-342, the inactive enolase is secreted, and remains attached to the cell surface. +P0AB83 END3_ECOLI Endonuclease III (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase) nth b1633 JW1625 nth 23,562 base-excision repair, AP site formation [GO:0006285]; base-excision repair, AP site formation via deaminated base removal [GO:0097510]; cellular response to UV [GO:0034644] 4 iron, 4 sulfur cluster binding [GO:0051539]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; DNA binding [GO:0003677]; DNA N-glycosylase activity [GO:0019104]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; metal ion binding [GO:0046872]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]; uracil DNA N-glycosylase activity [GO:0004844]; base-excision repair, AP site formation [GO:0006285]; base-excision repair, AP site formation via deaminated base removal [GO:0097510]; cellular response to UV [GO:0034644] 4 iron, 4 sulfur cluster binding [GO:0051539]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; DNA binding [GO:0003677]; DNA N-glycosylase activity [GO:0019104]; metal ion binding [GO:0046872]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]; uracil DNA N-glycosylase activity [GO:0004844] GO:0000703; GO:0003677; GO:0003906; GO:0004844; GO:0006285; GO:0019104; GO:0034644; GO:0046872; GO:0051539; GO:0097510; GO:0140078 +P25736 END1_ECOLI Endonuclease-1 (EC 3.1.21.1) (Endonuclease I) (Endo I) endA b2945 JW2912 endA 26,709 DNA catabolic process [GO:0006308] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; deoxyribonuclease I activity [GO:0004530]; endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888]; endonuclease activity [GO:0004519]; DNA catabolic process [GO:0006308] deoxyribonuclease I activity [GO:0004530]; endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888]; endonuclease activity [GO:0004519] GO:0004519; GO:0004530; GO:0006308; GO:0016888; GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:4955462}. +P76553 EUTG_ECOLI Probable alcohol dehydrogenase EutG (EC 1.1.1.1) (Ethanolamine utilization protein EutG) eutG yffV b2453 JW2437 yffV eutG 41,031 ethanolamine catabolic process [GO:0046336] cytosol [GO:0005829] cytosol [GO:0005829]; alcohol dehydrogenase (NAD+) activity [GO:0004022]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; ethanolamine catabolic process [GO:0046336] alcohol dehydrogenase (NAD+) activity [GO:0004022]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] GO:0004022; GO:0005829; GO:0016616; GO:0046336; GO:0046872 SUBCELLULAR LOCATION: Bacterial microcompartment {ECO:0000250|UniProtKB:P0A9S1}. +P21515 ACPH_ECOLI Acyl carrier protein phosphodiesterase (ACP phosphodiesterase) (EC 3.1.4.14) acpH yajB b0404 JW0394 yajB acpH 22,961 fatty acid biosynthetic process [GO:0006633] [acyl-carrier-protein] phosphodiesterase activity [GO:0008770]; fatty acid biosynthetic process [GO:0006633] [acyl-carrier-protein] phosphodiesterase activity [GO:0008770] GO:0006633; GO:0008770 +P30871 3PASE_ECOLI Inorganic triphosphatase (PPPase) (EC 3.6.1.25) (ORFXE) ygiF b3054 JW3026 ygiF 48,389 metal ion binding [GO:0046872]; triphosphatase activity [GO:0050355] metal ion binding [GO:0046872]; triphosphatase activity [GO:0050355] GO:0046872; GO:0050355 +P37623 ACPT_ECOLI 4'-phosphopantetheinyl transferase AcpT (EC 2.7.8.7) acpT yhhU b3475 JW3440 yhhU acpT 21,768 fatty acid biosynthetic process [GO:0006633]; lysine biosynthetic process via aminoadipic acid [GO:0019878]; peptidyl-serine phosphopantetheinylation [GO:0018070] cytosol [GO:0005829] cytosol [GO:0005829]; holo-[acyl-carrier-protein] synthase activity [GO:0008897]; magnesium ion binding [GO:0000287]; fatty acid biosynthetic process [GO:0006633]; lysine biosynthetic process via aminoadipic acid [GO:0019878]; peptidyl-serine phosphopantetheinylation [GO:0018070] holo-[acyl-carrier-protein] synthase activity [GO:0008897]; magnesium ion binding [GO:0000287] GO:0000287; GO:0005829; GO:0006633; GO:0008897; GO:0018070; GO:0019878 +P31466 ADEP_ECOLI Adenine permease AdeP adeP purP yieG b3714 JW3692 purP yieG adeP 46,866 adenine transport [GO:0015853] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; adenine transmembrane transporter activity [GO:0015207]; purine nucleobase transmembrane transporter activity [GO:0005345]; solute:proton symporter activity [GO:0015295]; adenine transport [GO:0015853] adenine transmembrane transporter activity [GO:0015207]; purine nucleobase transmembrane transporter activity [GO:0005345]; solute:proton symporter activity [GO:0015295] GO:0005345; GO:0005886; GO:0015207; GO:0015295; GO:0015853; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:24214977}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:24214977}. +P32718 ALSK_ECOLI D-allose kinase (Allokinase) (EC 2.7.1.55) alsK yjcT b4084 JW5724 yjcT alsK 33,821 D-allose catabolic process [GO:0019316]; transcription, DNA-templated [GO:0006351] allose kinase activity [GO:0008787]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; glucokinase activity [GO:0004340]; D-allose catabolic process [GO:0019316]; transcription, DNA-templated [GO:0006351] allose kinase activity [GO:0008787]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; glucokinase activity [GO:0004340] GO:0003677; GO:0004340; GO:0005524; GO:0006351; GO:0008787; GO:0019316 +P40711 ARFB_ECOLI Peptidyl-tRNA hydrolase ArfB (PTH) (EC 3.1.1.29) (Alternative ribosome-rescue factor B) arfB yaeJ b0191 JW0187 yaeJ arfB 15,623 rescue of stalled ribosome [GO:0072344] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; aminoacyl-tRNA hydrolase activity [GO:0004045]; ribosome binding [GO:0043022]; translation release factor activity [GO:0003747]; rescue of stalled ribosome [GO:0072344] aminoacyl-tRNA hydrolase activity [GO:0004045]; ribosome binding [GO:0043022]; translation release factor activity [GO:0003747] GO:0003747; GO:0004045; GO:0005737; GO:0043022; GO:0072344 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P76127 BDM_ECOLI Protein bdm (Biofilm-dependent modulation protein) bdm yddX b1481 JW5239 yddX bdm 7,987 positive regulation of bacterial-type flagellum assembly [GO:1902210] positive regulation of bacterial-type flagellum assembly [GO:1902210] GO:1902210 +P31469 CBRC_ECOLI UPF0167 protein CbrC (CreB-regulated gene C protein) cbrC yieJ b3717 JW3695 yieJ cbrC 22,485 bacteriocin immunity [GO:0030153] bacteriocin immunity [GO:0030153] GO:0030153 +Q46899 CASC_ECOLI CRISPR system Cascade subunit CasC casC cas4 cse4 ygcJ b2758 JW2728 cas4 cse4 ygcJ casC 40,025 defense response to virus [GO:0051607] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; DNA/RNA hybrid binding [GO:0071667]; RNA binding [GO:0003723]; defense response to virus [GO:0051607] DNA/RNA hybrid binding [GO:0071667]; RNA binding [GO:0003723] GO:0003723; GO:0032991; GO:0051607; GO:0071667 +P39163 CHAC_ECOLI Glutathione-specific gamma-glutamylcyclotransferase (Gamma-GCG) (EC 4.3.2.7) (Cation transport regulatory protein ChaC) chaC b1218 JW1209 chaC 25,512 bacterial-type flagellum-dependent cell motility [GO:0071973]; glutathione catabolic process [GO:0006751] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; gamma-glutamylcyclotransferase activity [GO:0003839]; glutathione specific gamma-glutamylcyclotransferase activity [GO:0061928]; bacterial-type flagellum-dependent cell motility [GO:0071973]; glutathione catabolic process [GO:0006751] gamma-glutamylcyclotransferase activity [GO:0003839]; glutathione specific gamma-glutamylcyclotransferase activity [GO:0061928] GO:0003839; GO:0005737; GO:0006751; GO:0061928; GO:0071973 +P0ABM1 CCMC_ECOLI Heme exporter protein C (Cytochrome c-type biogenesis protein CcmC) ccmC yejT yejU b2199 JW2187 yejT yejU ccmC 27,885 cytochrome complex assembly [GO:0017004]; heme transport [GO:0015886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232]; cytochrome complex assembly [GO:0017004]; heme transport [GO:0015886] heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232] GO:0005886; GO:0005887; GO:0015232; GO:0015886; GO:0017004; GO:0020037 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77445 EUTE_ECOLI Acetaldehyde dehydrogenase (acetylating) EutE (EC 1.2.1.10) (Ethanolamine utilization protein EutE) eutE yffX b2455 JW2439 yffX eutE 49,022 ethanolamine catabolic process [GO:0046336] acetaldehyde dehydrogenase (acetylating) activity [GO:0008774]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; ethanolamine catabolic process [GO:0046336] acetaldehyde dehydrogenase (acetylating) activity [GO:0008774]; aldehyde dehydrogenase (NAD+) activity [GO:0004029] GO:0004029; GO:0008774; GO:0046336 SUBCELLULAR LOCATION: Bacterial microcompartment {ECO:0000250|UniProtKB:P41793}. Note=Probably located inside the BMC. {ECO:0000250|UniProtKB:P41793}. +P64638 FEOC_ECOLI Probable [Fe-S]-dependent transcriptional repressor FeoC (Fe(2+) iron transport protein C) feoC yhgG b3410 JW3373 yhgG feoC 8,660 DNA binding [GO:0003677]; iron ion binding [GO:0005506]; iron-sulfur cluster binding [GO:0051536] DNA binding [GO:0003677]; iron ion binding [GO:0005506]; iron-sulfur cluster binding [GO:0051536] GO:0003677; GO:0005506; GO:0051536 +P0ABH0 FTSA_ECOLI Cell division protein FtsA ftsA divA b0094 JW0092 divA ftsA 45,330 cell division [GO:0051301]; FtsZ-dependent cytokinesis [GO:0043093] cell division site [GO:0032153]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829] cell division site [GO:0032153]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; cell division [GO:0051301]; FtsZ-dependent cytokinesis [GO:0043093] ATP binding [GO:0005524]; identical protein binding [GO:0042802] GO:0005524; GO:0005829; GO:0009898; GO:0032153; GO:0042802; GO:0043093; GO:0051301 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15752196, ECO:0000269|PubMed:2203741}; Peripheral membrane protein {ECO:0000269|PubMed:15752196, ECO:0000269|PubMed:2203741}; Cytoplasmic side {ECO:0000269|PubMed:15752196, ECO:0000269|PubMed:2203741}. Note=Localizes to the Z ring in an FtsZ-dependent manner (PubMed:8955398, PubMed:8917533, PubMed:9495771). Targeted to the membrane through a conserved C-terminal amphiphatic helix (PubMed:15752196). {ECO:0000269|PubMed:15752196, ECO:0000269|PubMed:8917533, ECO:0000269|PubMed:8955398, ECO:0000269|PubMed:9495771}. +P75882 GFCD_ECOLI Uncharacterized lipoprotein GfcD (Group 4 capsule protein D homolog) gfcD ymcA b0984 JW0967 ymcA gfcD 78,687 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P32719 ALSE_ECOLI D-allulose-6-phosphate 3-epimerase (EC 5.1.3.-) alsE yjcU b4085 JW4046 yjcU alsE 26,109 cellular carbohydrate metabolic process [GO:0044262]; D-allose catabolic process [GO:0019316]; pentose catabolic process [GO:0019323]; pentose-phosphate shunt, non-oxidative branch [GO:0009052] cytosol [GO:0005829] cytosol [GO:0005829]; allulose 6-phosphate 3-epimerase activity [GO:0034700]; metal ion binding [GO:0046872]; ribulose-phosphate 3-epimerase activity [GO:0004750]; cellular carbohydrate metabolic process [GO:0044262]; D-allose catabolic process [GO:0019316]; pentose catabolic process [GO:0019323]; pentose-phosphate shunt, non-oxidative branch [GO:0009052] allulose 6-phosphate 3-epimerase activity [GO:0034700]; metal ion binding [GO:0046872]; ribulose-phosphate 3-epimerase activity [GO:0004750] GO:0004750; GO:0005829; GO:0009052; GO:0019316; GO:0019323; GO:0034700; GO:0044262; GO:0046872 +P26458 APPB_ECOLI Cytochrome bd-II ubiquinol oxidase subunit 2 (EC 7.1.1.3) (Cytochrome bd-II oxidase subunit II) appB cbdB cyxB b0979 JW0961 cbdB cyxB appB 42,424 aerobic electron transport chain [GO:0019646]; oxidative phosphorylation [GO:0006119] cytochrome complex [GO:0070069]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] cytochrome complex [GO:0070069]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cytochrome bo3 ubiquinol oxidase activity [GO:0009486]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [GO:0016682]; aerobic electron transport chain [GO:0019646]; oxidative phosphorylation [GO:0006119] cytochrome bo3 ubiquinol oxidase activity [GO:0009486]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [GO:0016682] GO:0005886; GO:0006119; GO:0009055; GO:0009486; GO:0016021; GO:0016682; GO:0019646; GO:0046872; GO:0070069 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P15034 AMPP_ECOLI Xaa-Pro aminopeptidase (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Aminopeptidase P II) (APP-II) (X-Pro aminopeptidase) pepP b2908 JW2876 pepP 49,815 protein homotetramerization [GO:0051289] cytosol [GO:0005829] cytosol [GO:0005829]; aminopeptidase activity [GO:0004177]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; peptidase activity [GO:0008233]; protein homotetramerization [GO:0051289] aminopeptidase activity [GO:0004177]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; metalloexopeptidase activity [GO:0008235]; peptidase activity [GO:0008233] GO:0004177; GO:0005829; GO:0008233; GO:0008235; GO:0030145; GO:0042802; GO:0051289; GO:0070006 SUBCELLULAR LOCATION: Cytoplasm. +P28246 BCR_ECOLI Bicyclomycin resistance protein (Sulfonamide resistance protein) bcr bicA bicR sur suxA b2182 JW5363 bicA bicR sur suxA bcr 43,353 cysteine export across plasma membrane [GO:0033228]; dipeptide transmembrane transport [GO:0035442]; protein transport [GO:0015031]; response to antibiotic [GO:0046677]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cysteine transmembrane transporter activity [GO:0033229]; dipeptide transmembrane transporter activity [GO:0071916]; xenobiotic transmembrane transporter activity [GO:0042910]; cysteine export across plasma membrane [GO:0033228]; dipeptide transmembrane transport [GO:0035442]; protein transport [GO:0015031]; response to antibiotic [GO:0046677]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] cysteine transmembrane transporter activity [GO:0033229]; dipeptide transmembrane transporter activity [GO:0071916]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0005887; GO:0015031; GO:0016021; GO:0033228; GO:0033229; GO:0035442; GO:0042910; GO:0046677; GO:0071916; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P0AE85 CPXP_ECOLI Periplasmic protein CpxP (ORF_o167) (Periplasmic accessory protein CpxP) cpxP yiiO b4484 JW5558 yiiO cpxP 18,965 ATP-independent chaperone mediated protein folding [GO:1990507] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; identical protein binding [GO:0042802]; unfolded protein binding [GO:0051082]; ATP-independent chaperone mediated protein folding [GO:1990507] identical protein binding [GO:0042802]; unfolded protein binding [GO:0051082] GO:0030288; GO:0042802; GO:0051082; GO:1990507 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:25207645, ECO:0000269|PubMed:9473036}. +P0AE82 CPXA_ECOLI Sensor histidine kinase CpxA (EC 2.7.13.3) cpxA ecfB eup ssd b3911 JW3882 ecfB eup ssd cpxA 51,624 cell adhesion involved in biofilm formation [GO:0043708]; cellular response to cell envelope stress [GO:0036460]; peptidyl-histidine phosphorylation [GO:0018106]; protein autophosphorylation [GO:0046777]; response to radiation [GO:0009314]; signal transduction [GO:0007165] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155]; cell adhesion involved in biofilm formation [GO:0043708]; cellular response to cell envelope stress [GO:0036460]; peptidyl-histidine phosphorylation [GO:0018106]; protein autophosphorylation [GO:0046777]; response to radiation [GO:0009314]; signal transduction [GO:0007165] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155] GO:0000155; GO:0004721; GO:0005524; GO:0005829; GO:0005886; GO:0005887; GO:0007165; GO:0009314; GO:0016021; GO:0018106; GO:0030288; GO:0036460; GO:0042802; GO:0043708; GO:0046777 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:25207645, ECO:0000269|PubMed:3058985}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996, ECO:0000305|PubMed:3058985}. +P24251 CRL_ECOLI Sigma factor-binding protein Crl (Curlin genes transcriptional activatory protein) crl b0240 JW0230 crl 15,655 positive regulation of transcription, DNA-templated [GO:0045893] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; positive regulation of transcription, DNA-templated [GO:0045893] GO:0005737; GO:0045893 SUBCELLULAR LOCATION: Cytoplasm. +P0DM85 CRFC_ECOLI Clamp-binding protein CrfC (Clamp-binding sister replication fork colocalization protein) crfC yjdA b4109 JW4070 yjdA crfC 84,371 chromosome segregation [GO:0007059]; DNA replication [GO:0006260]; ribosomal large subunit assembly [GO:0000027] cytosol [GO:0005829] cytosol [GO:0005829]; GTP binding [GO:0005525]; ribosome binding [GO:0043022]; chromosome segregation [GO:0007059]; DNA replication [GO:0006260]; ribosomal large subunit assembly [GO:0000027] GTP binding [GO:0005525]; ribosome binding [GO:0043022] GO:0000027; GO:0005525; GO:0005829; GO:0006260; GO:0007059; GO:0043022 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23994470}. Note=About half the protein co-localizes with beta sliding clamp (DnaN) at midcell, the rest without clamp in quarter-cell positions when chromosomes are condensed during DNA replication. +A5A624 DINQ_ECOLI Uncharacterized protein DinQ dinQ b4613 dinQ 3,021 cellular response to DNA damage stimulus [GO:0006974] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cellular response to DNA damage stimulus [GO:0006974] GO:0005886; GO:0006974; GO:0016020; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P77694 ECPD_ECOLI Fimbria adhesin EcpD ecpD matE yagW b0290 JW0284 matE yagW ecpD 59,997 pilus [GO:0009289] pilus [GO:0009289] GO:0009289 SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}. +P0ADQ2 FABY_ECOLI Probable acyltransferase FabY (EC 2.3.1.-) fabY yiiD b3888 JW3859 yiiD fabY 37,094 fatty acid biosynthetic process [GO:0006633]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] glucosamine 6-phosphate N-acetyltransferase activity [GO:0004343]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747]; fatty acid biosynthetic process [GO:0006633]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] glucosamine 6-phosphate N-acetyltransferase activity [GO:0004343]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] GO:0004343; GO:0006048; GO:0006633; GO:0016747 +P39280 EPMB_ECOLI L-lysine 2,3-aminomutase (LAM) (EC 5.4.3.-) (EF-P post-translational modification enzyme B) epmB yjeK b4146 JW4106 yjeK epmB 38,750 4 iron, 4 sulfur cluster binding [GO:0051539]; intramolecular transferase activity, transferring amino groups [GO:0016869]; metal ion binding [GO:0046872] 4 iron, 4 sulfur cluster binding [GO:0051539]; intramolecular transferase activity, transferring amino groups [GO:0016869]; metal ion binding [GO:0046872] GO:0016869; GO:0046872; GO:0051539 +P77609 FLXA_ECOLI Protein FlxA flxA b1566 JW1558 flxA 12,208 +P0A9E5 FNR_ECOLI Fumarate and nitrate reduction regulatory protein fnr nirR b1334 JW1328 nirR fnr 27,967 anaerobic respiration [GO:0009061]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; response to nitric oxide [GO:0071731] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; 4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; anaerobic respiration [GO:0009061]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; response to nitric oxide [GO:0071731] 4 iron, 4 sulfur cluster binding [GO:0051539]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0001216; GO:0003677; GO:0003700; GO:0005829; GO:0006355; GO:0009061; GO:0032993; GO:0045893; GO:0046872; GO:0051536; GO:0051539; GO:0071731 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A9R4 FER_ECOLI 2Fe-2S ferredoxin fdx b2525 JW2509 fdx 12,331 iron-sulfur cluster assembly [GO:0016226] cytosol [GO:0005829] cytosol [GO:0005829]; 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; iron-sulfur cluster assembly [GO:0016226] 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] GO:0005829; GO:0009055; GO:0016226; GO:0046872; GO:0051537 +P06974 FLIM_ECOLI Flagellar motor switch protein FliM fliM cheC2 fla AII fla QII b1945 JW1929 cheC2 fla AII fla QII fliM 37,849 bacterial-type flagellum-dependent cell motility [GO:0071973]; positive chemotaxis [GO:0050918] bacterial-type flagellum basal body [GO:0009425]; plasma membrane [GO:0005886] bacterial-type flagellum basal body [GO:0009425]; plasma membrane [GO:0005886]; motor activity [GO:0003774]; bacterial-type flagellum-dependent cell motility [GO:0071973]; positive chemotaxis [GO:0050918] motor activity [GO:0003774] GO:0003774; GO:0005886; GO:0009425; GO:0050918; GO:0071973 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. Bacterial flagellum basal body. +P24216 FLID_ECOLI Flagellar hook-associated protein 2 (HAP2) (Filament cap protein) (Flagellar cap protein) fliD flaV flbC b1924 JW1909 flaV flbC fliD 48,456 bacterial-type flagellum-dependent cell motility [GO:0071973]; cell adhesion [GO:0007155] bacterial-type flagellum filament cap [GO:0009421]; bacterial-type flagellum hook [GO:0009424]; extracellular region [GO:0005576] bacterial-type flagellum filament cap [GO:0009421]; bacterial-type flagellum hook [GO:0009424]; extracellular region [GO:0005576]; bacterial-type flagellum-dependent cell motility [GO:0071973]; cell adhesion [GO:0007155] GO:0005576; GO:0007155; GO:0009421; GO:0009424; GO:0071973 SUBCELLULAR LOCATION: Secreted. Bacterial flagellum. +P75780 FIU_ECOLI Catecholate siderophore receptor Fiu (Ferric iron uptake protein) (TonB-dependent receptor Fiu) fiu ybiL b0805 JW0790 ybiL fiu 81,960 iron ion homeostasis [GO:0055072]; microcin transport [GO:0042884]; siderophore transport [GO:0015891] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; siderophore uptake transmembrane transporter activity [GO:0015344]; signaling receptor activity [GO:0038023]; iron ion homeostasis [GO:0055072]; microcin transport [GO:0042884]; siderophore transport [GO:0015891] siderophore uptake transmembrane transporter activity [GO:0015344]; signaling receptor activity [GO:0038023] GO:0009279; GO:0015344; GO:0015891; GO:0016021; GO:0038023; GO:0042884; GO:0055072 SUBCELLULAR LOCATION: Cell outer membrane. +P23872 AES_ECOLI Acetyl esterase (EC 3.1.1.-) (EcE) aes ybaC b0476 JW0465 ybaC aes 36,034 negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of hydrolase activity [GO:0051346] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; acetylesterase activity [GO:0008126]; hydrolase activity [GO:0016787]; short-chain carboxylesterase activity [GO:0034338]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of hydrolase activity [GO:0051346] acetylesterase activity [GO:0008126]; hydrolase activity [GO:0016787]; short-chain carboxylesterase activity [GO:0034338] GO:0005737; GO:0008126; GO:0016787; GO:0034338; GO:0043433; GO:0051346 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9576853}. +P31224 ACRB_ECOLI Multidrug efflux pump subunit AcrB (AcrAB-TolC multidrug efflux pump subunit AcrB) (Acridine resistance protein B) acrB acrE b0462 JW0451 acrE acrB 113,574 efflux pump complex [GO:1990281]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] efflux pump complex [GO:1990281]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; efflux transmembrane transporter activity [GO:0015562]; identical protein binding [GO:0042802]; xenobiotic transmembrane transporter activity [GO:0042910] efflux transmembrane transporter activity [GO:0015562]; identical protein binding [GO:0042802]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0005887; GO:0015562; GO:0016020; GO:0030288; GO:0042802; GO:0042910; GO:1990281 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137}. +P0A9Q1 ARCA_ECOLI Aerobic respiration control protein ArcA (Dye resistance protein) arcA cpxC dye fexA msp seg sfrA b4401 JW4364 cpxC dye fexA msp seg sfrA arcA 27,292 negative regulation of transcription, DNA-templated [GO:0045892]; phosphorelay signal transduction system [GO:0000160]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; phosphorelay signal transduction system [GO:0000160]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000160; GO:0000976; GO:0001216; GO:0001217; GO:0003700; GO:0005829; GO:0006355; GO:0032993; GO:0042802; GO:0045892; GO:0045893 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AEC3 ARCB_ECOLI Aerobic respiration control sensor protein ArcB (EC 2.7.13.3) arcB b3210 JW5536 arcB 87,983 peptidyl-histidine phosphorylation [GO:0018106]; protein autophosphorylation [GO:0046777]; regulation of transcription, DNA-templated [GO:0006355]; response to oxygen levels [GO:0070482]; signal transduction [GO:0007165] cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155]; peptidyl-histidine phosphorylation [GO:0018106]; protein autophosphorylation [GO:0046777]; regulation of transcription, DNA-templated [GO:0006355]; response to oxygen levels [GO:0070482]; signal transduction [GO:0007165] ATP binding [GO:0005524]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155] GO:0000155; GO:0004721; GO:0005524; GO:0005829; GO:0005886; GO:0005887; GO:0006355; GO:0007165; GO:0018106; GO:0046777; GO:0070482 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0DTT0 BIPA_ECOLI 50S ribosomal subunit assembly factor BipA (EC 3.6.5.-) (GTP-binding protein BipA/TypA) (Ribosome assembly factor BipA) (Ribosome-dependent GTPase BipA) (Tyrosine phosphorylated protein A) bipA o591 typA yihK b3871 JW5571 o591 typA yihK bipA 67,355 ribosomal large subunit assembly [GO:0000027] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843]; tRNA binding [GO:0000049]; ribosomal large subunit assembly [GO:0000027] GTPase activity [GO:0003924]; GTP binding [GO:0005525]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843]; tRNA binding [GO:0000049] GO:0000027; GO:0000049; GO:0003924; GO:0005525; GO:0005737; GO:0019843; GO:0043022 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00849, ECO:0000269|PubMed:30305394, ECO:0000269|Ref.12}. Note=Associates with 70S ribosomes and 30S and 50S subunits in the presence of GMPPNP (a nonhydrolyzable GTP analog) at both 20 and 37 degrees Celsius; no change in ribosome association is seen in the presence of ppGpp or when the stringent response is triggered. {ECO:0000269|PubMed:30305394}. +P75980 BEEE_ECOLI Protein BeeE beeE ymfO b1151 JW1137 ymfO beeE 17,609 +P37047 CDAR_ECOLI Carbohydrate diacid regulator (Sugar diacid regulator) cdaR sdaR yaeG b0162 JW5013 sdaR yaeG cdaR 43,687 positive regulation of transcription, DNA-templated [GO:0045893] DNA-binding transcription factor activity [GO:0003700]; positive regulation of transcription, DNA-templated [GO:0045893] DNA-binding transcription factor activity [GO:0003700] GO:0003700; GO:0045893 +P16701 CYST_ECOLI Sulfate transport system permease protein CysT cysU cysT b2424 JW2417 cysT cysU 30,292 sulfate transport [GO:0008272] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ABC-type sulfate transporter activity [GO:0015419]; sulfate transport [GO:0008272] ABC-type sulfate transporter activity [GO:0015419] GO:0005886; GO:0008272; GO:0015419; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:15919996}. +P0ABI8 CYOB_ECOLI Cytochrome bo(3) ubiquinol oxidase subunit 1 (EC 7.1.1.3) (Cytochrome b562-o complex subunit I) (Cytochrome o ubiquinol oxidase subunit 1) (Cytochrome o subunit 1) (Oxidase bo(3) subunit 1) (Ubiquinol oxidase chain A) (Ubiquinol oxidase polypeptide I) (Ubiquinol oxidase subunit 1) cyoB b0431 JW0421 cyoB 74,368 aerobic electron transport chain [GO:0019646]; aerobic respiration [GO:0009060]; electron transport coupled proton transport [GO:0015990]; respiratory electron transport chain [GO:0022904] cytochrome o ubiquinol oxidase complex [GO:0009319]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; respirasome [GO:0070469] cytochrome o ubiquinol oxidase complex [GO:0009319]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; respirasome [GO:0070469]; copper ion binding [GO:0005507]; cytochrome bo3 ubiquinol oxidase activity [GO:0009486]; cytochrome-c oxidase activity [GO:0004129]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [GO:0016682]; oxidoreduction-driven active transmembrane transporter activity [GO:0015453]; proton transmembrane transporter activity [GO:0015078]; ubiquinone binding [GO:0048039]; aerobic electron transport chain [GO:0019646]; aerobic respiration [GO:0009060]; electron transport coupled proton transport [GO:0015990]; respiratory electron transport chain [GO:0022904] copper ion binding [GO:0005507]; cytochrome bo3 ubiquinol oxidase activity [GO:0009486]; cytochrome-c oxidase activity [GO:0004129]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [GO:0016682]; oxidoreduction-driven active transmembrane transporter activity [GO:0015453]; proton transmembrane transporter activity [GO:0015078]; ubiquinone binding [GO:0048039] GO:0004129; GO:0005507; GO:0005886; GO:0005887; GO:0009055; GO:0009060; GO:0009319; GO:0009486; GO:0015078; GO:0015453; GO:0015990; GO:0016682; GO:0019646; GO:0020037; GO:0022904; GO:0048039; GO:0070469 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:6365921}; Multi-pass membrane protein {ECO:0000269|PubMed:6365921}. +P08550 CVPA_ECOLI Colicin V production protein (Protein DedE) (Pur regulon 18 kDa protein) cvpA dedE b2313 JW2310 dedE cvpA 17,907 toxin biosynthetic process [GO:0009403] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; toxin biosynthetic process [GO:0009403] GO:0005886; GO:0009403; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P37195 DCTR_ECOLI HTH-type transcriptional regulator DctR dctR yhiF b3507 JW3475 yhiF dctR 20,408 regulation of cellular carbohydrate catabolic process [GO:0043471]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; regulation of cellular carbohydrate catabolic process [GO:0043471]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677] GO:0003677; GO:0006355; GO:0043471 +P0C0V0 DEGP_ECOLI Periplasmic serine endoprotease DegP (EC 3.4.21.107) (Heat shock protein DegP) (Protease Do) degP htrA ptd b0161 JW0157 htrA ptd degP 49,354 chaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; proteolysis [GO:0006508]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]; response to temperature stimulus [GO:0009266] outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; chaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; proteolysis [GO:0006508]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]; response to temperature stimulus [GO:0009266] identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] GO:0004252; GO:0005886; GO:0006457; GO:0006508; GO:0006515; GO:0006979; GO:0008233; GO:0008236; GO:0009266; GO:0009408; GO:0030288; GO:0042802; GO:0061077 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:9083020}; Peripheral membrane protein {ECO:0000269|PubMed:9083020}; Cytoplasmic side {ECO:0000269|PubMed:9083020}. +P66817 DIAA_ECOLI DnaA initiator-associating protein DiaA diaA yraO b3149 JW3118 yraO diaA 21,106 carbohydrate derivative metabolic process [GO:1901135]; DNA replication [GO:0006260]; positive regulation of DNA-dependent DNA replication initiation [GO:0032298] carbohydrate derivative binding [GO:0097367]; identical protein binding [GO:0042802]; carbohydrate derivative metabolic process [GO:1901135]; DNA replication [GO:0006260]; positive regulation of DNA-dependent DNA replication initiation [GO:0032298] carbohydrate derivative binding [GO:0097367]; identical protein binding [GO:0042802] GO:0006260; GO:0032298; GO:0042802; GO:0097367; GO:1901135 +P76015 DHAK_ECOLI PEP-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK (EC 2.7.1.121) dhaK ycgT b1200 JW5187 ycgT dhaK 38,215 cellular response to DNA damage stimulus [GO:0006974]; glycerol catabolic process [GO:0019563]; glycerol to glycerone phosphate metabolic process [GO:0061610]; ketone catabolic process [GO:0042182]; monosaccharide catabolic process [GO:0046365] cytosol [GO:0005829] cytosol [GO:0005829]; glycerone kinase activity [GO:0004371]; identical protein binding [GO:0042802]; phosphoenolpyruvate-glycerone phosphotransferase activity [GO:0047324]; cellular response to DNA damage stimulus [GO:0006974]; glycerol catabolic process [GO:0019563]; glycerol to glycerone phosphate metabolic process [GO:0061610]; ketone catabolic process [GO:0042182]; monosaccharide catabolic process [GO:0046365] glycerone kinase activity [GO:0004371]; identical protein binding [GO:0042802]; phosphoenolpyruvate-glycerone phosphotransferase activity [GO:0047324] GO:0004371; GO:0005829; GO:0006974; GO:0019563; GO:0042182; GO:0042802; GO:0046365; GO:0047324; GO:0061610 +P77488 DXS_ECOLI 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) dxs yajP b0420 JW0410 yajP dxs 67,617 1-deoxy-D-xylulose 5-phosphate biosynthetic process [GO:0052865]; isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; isoprenoid biosynthetic process [GO:0008299]; pyridoxine biosynthetic process [GO:0008615]; terpenoid biosynthetic process [GO:0016114]; thiamine biosynthetic process [GO:0009228]; ubiquinone biosynthetic process [GO:0006744] cytosol [GO:0005829] cytosol [GO:0005829]; 1-deoxy-D-xylulose-5-phosphate synthase activity [GO:0008661]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976]; transferase activity, transferring aldehyde or ketonic groups [GO:0016744]; 1-deoxy-D-xylulose 5-phosphate biosynthetic process [GO:0052865]; isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; isoprenoid biosynthetic process [GO:0008299]; pyridoxine biosynthetic process [GO:0008615]; terpenoid biosynthetic process [GO:0016114]; thiamine biosynthetic process [GO:0009228]; ubiquinone biosynthetic process [GO:0006744] 1-deoxy-D-xylulose-5-phosphate synthase activity [GO:0008661]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976]; transferase activity, transferring aldehyde or ketonic groups [GO:0016744] GO:0000287; GO:0005829; GO:0006744; GO:0008299; GO:0008615; GO:0008661; GO:0009228; GO:0016114; GO:0016744; GO:0019288; GO:0030976; GO:0052865 +P0ABQ4 DYR_ECOLI Dihydrofolate reductase (EC 1.5.1.3) folA tmrA b0048 JW0047 tmrA folA 17,999 dihydrofolate metabolic process [GO:0046452]; folic acid metabolic process [GO:0046655]; glycine biosynthetic process [GO:0006545]; one-carbon metabolic process [GO:0006730]; response to antibiotic [GO:0046677]; response to drug [GO:0042493]; response to methotrexate [GO:0031427]; tetrahydrofolate biosynthetic process [GO:0046654] cytosol [GO:0005829] cytosol [GO:0005829]; dihydrofolate reductase activity [GO:0004146]; dihydrofolic acid binding [GO:0051871]; folic acid binding [GO:0005542]; methotrexate binding [GO:0051870]; NADP binding [GO:0050661]; NADP+ binding [GO:0070401]; NADPH binding [GO:0070402]; dihydrofolate metabolic process [GO:0046452]; folic acid metabolic process [GO:0046655]; glycine biosynthetic process [GO:0006545]; one-carbon metabolic process [GO:0006730]; response to antibiotic [GO:0046677]; response to drug [GO:0042493]; response to methotrexate [GO:0031427]; tetrahydrofolate biosynthetic process [GO:0046654] dihydrofolate reductase activity [GO:0004146]; dihydrofolic acid binding [GO:0051871]; folic acid binding [GO:0005542]; methotrexate binding [GO:0051870]; NADP+ binding [GO:0070401]; NADP binding [GO:0050661]; NADPH binding [GO:0070402] GO:0004146; GO:0005542; GO:0005829; GO:0006545; GO:0006730; GO:0031427; GO:0042493; GO:0046452; GO:0046654; GO:0046655; GO:0046677; GO:0050661; GO:0051870; GO:0051871; GO:0070401; GO:0070402 +P66899 DPAL_ECOLI Diaminopropionate ammonia-lyase (DAPAL) (EC 4.3.1.15) (2,3-diaminopropionate ammonia-lyase) (Alpha,beta-diaminopropionate ammonia-lyase) (Diaminopropionatase) ygeX b2871 JW2839 ygeX 43,328 cellular amino acid catabolic process [GO:0009063] diaminopropionate ammonia-lyase activity [GO:0008838]; pyridoxal phosphate binding [GO:0030170]; cellular amino acid catabolic process [GO:0009063] diaminopropionate ammonia-lyase activity [GO:0008838]; pyridoxal phosphate binding [GO:0030170] GO:0008838; GO:0009063; GO:0030170 +P0A959 ALAA_ECOLI Glutamate-pyruvate aminotransferase AlaA (EC 2.6.1.2) alaA yfbQ b2290 JW2287 yfbQ alaA 45,517 alanine biosynthetic process [GO:0006523]; cellular response to DNA damage stimulus [GO:0006974]; D-alanine biosynthetic process [GO:0030632]; L-alanine biosynthetic process from pyruvate [GO:0019272]; response to antibiotic [GO:0046677] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; L-alanine:2-oxoglutarate aminotransferase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]; alanine biosynthetic process [GO:0006523]; cellular response to DNA damage stimulus [GO:0006974]; D-alanine biosynthetic process [GO:0030632]; L-alanine biosynthetic process from pyruvate [GO:0019272]; response to antibiotic [GO:0046677] L-alanine:2-oxoglutarate aminotransferase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] GO:0004021; GO:0005737; GO:0006523; GO:0006974; GO:0008483; GO:0019272; GO:0030170; GO:0030632; GO:0046677 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P27250 AHR_ECOLI Aldehyde reductase Ahr (EC 1.1.1.2) (Zinc-dependent alcohol dehydrogenase Ahr) ahr yjgB b4269 JW5761 yjgB ahr 36,502 fatty acid metabolic process [GO:0006631] alcohol dehydrogenase (NADP+) activity [GO:0008106]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; zinc ion binding [GO:0008270]; fatty acid metabolic process [GO:0006631] alcohol dehydrogenase (NADP+) activity [GO:0008106]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; zinc ion binding [GO:0008270] GO:0006631; GO:0008106; GO:0008270; GO:0016616 +P76215 ASTE_ECOLI Succinylglutamate desuccinylase (EC 3.5.1.96) astE ydjS b1744 JW1733 ydjS astE 35,800 arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to succinate [GO:0019545] cytosol [GO:0005829] cytosol [GO:0005829]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; hydrolase activity, acting on ester bonds [GO:0016788]; succinylglutamate desuccinylase activity [GO:0009017]; zinc ion binding [GO:0008270]; arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to succinate [GO:0019545] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811]; hydrolase activity, acting on ester bonds [GO:0016788]; succinylglutamate desuccinylase activity [GO:0009017]; zinc ion binding [GO:0008270] GO:0005829; GO:0008270; GO:0009017; GO:0016788; GO:0016811; GO:0019544; GO:0019545 +P0AAE8 CADB_ECOLI Probable cadaverine/lysine antiporter cadB b4132 JW4093 cadB 46,665 cadaverine transport [GO:0015839]; cellular stress response to acidic pH [GO:1990451]; L-lysine transmembrane transport [GO:1903401] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297]; lysine:cadaverine antiporter activity [GO:0043872]; solute:proton symporter activity [GO:0015295]; cadaverine transport [GO:0015839]; cellular stress response to acidic pH [GO:1990451]; L-lysine transmembrane transport [GO:1903401] antiporter activity [GO:0015297]; lysine:cadaverine antiporter activity [GO:0043872]; solute:proton symporter activity [GO:0015295] GO:0005886; GO:0005887; GO:0015295; GO:0015297; GO:0015839; GO:0016020; GO:0043872; GO:1903401; GO:1990451 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P07364 CHER_ECOLI Chemotaxis protein methyltransferase (EC 2.1.1.80) cheR cheX b1884 JW1873 cheX cheR 32,849 chemotaxis [GO:0006935]; protein methylation [GO:0006479] cytosol [GO:0005829]; methyl accepting chemotaxis protein complex [GO:0098561]; plasma membrane [GO:0005886] cytosol [GO:0005829]; methyl accepting chemotaxis protein complex [GO:0098561]; plasma membrane [GO:0005886]; protein C-terminus binding [GO:0008022]; protein methyltransferase activity [GO:0008276]; protein-glutamate O-methyltransferase activity [GO:0008983]; chemotaxis [GO:0006935]; protein methylation [GO:0006479] protein C-terminus binding [GO:0008022]; protein-glutamate O-methyltransferase activity [GO:0008983]; protein methyltransferase activity [GO:0008276] GO:0005829; GO:0005886; GO:0006479; GO:0006935; GO:0008022; GO:0008276; GO:0008983; GO:0098561 +P08365 CHPS_ECOLI Antitoxin ChpS chpS chpBI yjfB b4224 JW5750 chpBI yjfB chpS 9,272 positive regulation of cell growth [GO:0030307] DNA binding [GO:0003677]; positive regulation of cell growth [GO:0030307] DNA binding [GO:0003677] GO:0003677; GO:0030307 +P76290 CMOA_ECOLI Carboxy-S-adenosyl-L-methionine synthase (Cx-SAM synthase) (EC 2.1.3.-) cmoA yecO b1870 JW1859 yecO cmoA 27,777 tRNA wobble uridine modification [GO:0002098] cytosol [GO:0005829] cytosol [GO:0005829]; carboxyl- or carbamoyltransferase activity [GO:0016743]; S-adenosyl-L-methionine binding [GO:1904047]; tRNA wobble uridine modification [GO:0002098] carboxyl- or carbamoyltransferase activity [GO:0016743]; S-adenosyl-L-methionine binding [GO:1904047] GO:0002098; GO:0005829; GO:0016743; GO:1904047 +P0AEA8 CYSG_ECOLI Siroheme synthase [Includes: Uroporphyrinogen-III C-methyltransferase (Urogen III methylase) (EC 2.1.1.107) (SUMT) (Uroporphyrinogen III methylase) (UROM); Precorrin-2 dehydrogenase (EC 1.3.1.76); Sirohydrochlorin ferrochelatase (EC 4.99.1.4)] cysG b3368 JW3331 cysG 49,951 cobalamin biosynthetic process [GO:0009236]; methylation [GO:0032259]; response to osmotic stress [GO:0006970]; siroheme biosynthetic process [GO:0019354] NAD binding [GO:0051287]; precorrin-2 dehydrogenase activity [GO:0043115]; sirohydrochlorin ferrochelatase activity [GO:0051266]; uroporphyrin-III C-methyltransferase activity [GO:0004851]; cobalamin biosynthetic process [GO:0009236]; methylation [GO:0032259]; response to osmotic stress [GO:0006970]; siroheme biosynthetic process [GO:0019354] NAD binding [GO:0051287]; precorrin-2 dehydrogenase activity [GO:0043115]; sirohydrochlorin ferrochelatase activity [GO:0051266]; uroporphyrin-III C-methyltransferase activity [GO:0004851] GO:0004851; GO:0006970; GO:0009236; GO:0019354; GO:0032259; GO:0043115; GO:0051266; GO:0051287 +P16700 CYSP_ECOLI Thiosulfate-binding protein cysP b2425 JW2418 cysP 37,615 sulfate transport [GO:0008272]; sulfur compound metabolic process [GO:0006790]; thiosulfate transport [GO:0015709] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; ABC-type sulfate transporter activity [GO:0015419]; sulfate binding [GO:0043199]; thiosulfate binding [GO:0036173]; sulfate transport [GO:0008272]; sulfur compound metabolic process [GO:0006790]; thiosulfate transport [GO:0015709] ABC-type sulfate transporter activity [GO:0015419]; sulfate binding [GO:0043199]; thiosulfate binding [GO:0036173] GO:0006790; GO:0008272; GO:0015419; GO:0015709; GO:0030288; GO:0036173; GO:0043199 SUBCELLULAR LOCATION: Periplasm. +P24228 DACB_ECOLI D-alanyl-D-alanine carboxypeptidase DacB (DD-carboxypeptidase) (DD-peptidase) (EC 3.4.16.4) (D-alanyl-D-alanine endopeptidase) (DD-endopeptidase) (EC 3.4.21.-) (Penicillin-binding protein 4) (PBP-4) dacB b3182 JW3149 dacB 51,798 cell wall macromolecule catabolic process [GO:0016998]; cell wall organization [GO:0071555]; FtsZ-dependent cytokinesis [GO:0043093]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan catabolic process [GO:0009253]; peptidoglycan metabolic process [GO:0000270]; peptidoglycan turnover [GO:0009254]; proteolysis [GO:0006508]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; carboxypeptidase activity [GO:0004180]; endopeptidase activity [GO:0004175]; penicillin binding [GO:0008658]; serine-type carboxypeptidase activity [GO:0004185]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002]; cell wall macromolecule catabolic process [GO:0016998]; cell wall organization [GO:0071555]; FtsZ-dependent cytokinesis [GO:0043093]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan catabolic process [GO:0009253]; peptidoglycan metabolic process [GO:0000270]; peptidoglycan turnover [GO:0009254]; proteolysis [GO:0006508]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] carboxypeptidase activity [GO:0004180]; endopeptidase activity [GO:0004175]; penicillin binding [GO:0008658]; serine-type carboxypeptidase activity [GO:0004185]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002] GO:0000270; GO:0004175; GO:0004180; GO:0004185; GO:0006508; GO:0008360; GO:0008658; GO:0009002; GO:0009252; GO:0009253; GO:0009254; GO:0016998; GO:0042597; GO:0043093; GO:0046677; GO:0071555 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P31459 DGOK_ECOLI 2-dehydro-3-deoxygalactonokinase (EC 2.7.1.58) (2-keto-3-deoxy-galactonokinase) (2-oxo-3-deoxygalactonate kinase) dgoK yidV b3693 JW3670 yidV dgoK 31,374 D-galactonate catabolic process [GO:0034194] 2-dehydro-3-deoxygalactonokinase activity [GO:0008671]; ATP binding [GO:0005524]; D-galactonate catabolic process [GO:0034194] 2-dehydro-3-deoxygalactonokinase activity [GO:0008671]; ATP binding [GO:0005524] GO:0005524; GO:0008671; GO:0034194 +P23827 ECOT_ECOLI Ecotin eco eti b2209 JW2197 eti eco 18,192 outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; serine-type endopeptidase inhibitor activity [GO:0004867] serine-type endopeptidase inhibitor activity [GO:0004867] GO:0004867; GO:0030288 SUBCELLULAR LOCATION: Periplasm. +P75901 EFEU_ECOLI Putative inactive ferrous iron permease EfeU (Putative Fe(2+) ion permease EfeU) efeU ycdN b4490 JW5141/JW1002 b1016/b1017 ycdN efeU 30,292 iron ion transmembrane transport [GO:0034755] high-affinity iron permease complex [GO:0033573]; plasma membrane [GO:0005886] high-affinity iron permease complex [GO:0033573]; plasma membrane [GO:0005886]; ferrous iron transmembrane transporter activity [GO:0015093]; iron ion transmembrane transport [GO:0034755] ferrous iron transmembrane transporter activity [GO:0015093] GO:0005886; GO:0015093; GO:0033573; GO:0034755 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. +P37661 EPTB_ECOLI Kdo(2)-lipid A phosphoethanolamine 7''-transferase (EC 2.7.8.42) (Phosphoethanolamine transferase EptB) eptB yhjW b3546 JW5660 yhjW eptB 63,804 lipid A biosynthetic process [GO:0009245]; lipopolysaccharide core region biosynthetic process [GO:0009244] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity [GO:0043838]; sulfuric ester hydrolase activity [GO:0008484]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide core region biosynthetic process [GO:0009244] phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity [GO:0043838]; sulfuric ester hydrolase activity [GO:0008484] GO:0005886; GO:0008484; GO:0009244; GO:0009245; GO:0016021; GO:0043838 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15795227}; Multi-pass membrane protein {ECO:0000269|PubMed:15795227}. +P39176 ERFK_ECOLI Probable L,D-transpeptidase ErfK/SrfK (EC 2.-.-.-) erfK yeeG yzzT b1990 JW1968 yeeG yzzT erfK 34,411 cell wall organization [GO:0071555]; peptidoglycan-protein cross-linking [GO:0018104]; regulation of cell shape [GO:0008360] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; peptidoglycan L,D-transpeptidase activity [GO:0071972]; transferase activity, transferring glycosyl groups [GO:0016757]; cell wall organization [GO:0071555]; peptidoglycan-protein cross-linking [GO:0018104]; regulation of cell shape [GO:0008360] peptidoglycan L,D-transpeptidase activity [GO:0071972]; transferase activity, transferring glycosyl groups [GO:0016757] GO:0008360; GO:0016757; GO:0018104; GO:0042597; GO:0071555; GO:0071972 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P75936 FLGD_ECOLI Basal-body rod modification protein FlgD flgD fla FIV flaV b1075 JW1062 fla FIV flaV flgD 23,575 bacterial-type flagellum-dependent swarming motility [GO:0071978]; bacterial-type flagellum organization [GO:0044781] bacterial-type flagellum hook [GO:0009424]; cytosol [GO:0005829] bacterial-type flagellum hook [GO:0009424]; cytosol [GO:0005829]; bacterial-type flagellum organization [GO:0044781]; bacterial-type flagellum-dependent swarming motility [GO:0071978] GO:0005829; GO:0009424; GO:0044781; GO:0071978 +P0A6R3 FIS_ECOLI DNA-binding protein Fis (Factor-for-inversion stimulation protein) (Hin recombinational enhancer-binding protein) fis b3261 JW3229 fis 11,240 bacterial transcription [GO:0001121]; chromatin organization involved in regulation of transcription [GO:0034401]; positive regulation of DNA recombination [GO:0045911]; provirus excision [GO:0032359]; regulation of transcription, DNA-templated [GO:0006355]; response to radiation [GO:0009314] cytosol [GO:0005829]; invertasome [GO:0031421]; nucleoid [GO:0009295]; nucleosome [GO:0000786]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; invertasome [GO:0031421]; nucleoid [GO:0009295]; nucleosome [GO:0000786]; protein-DNA complex [GO:0032993]; bacterial-type RNA polymerase core promoter sequence-specific DNA binding [GO:0000985]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription repressor activity [GO:0001217]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]; sequence-specific DNA binding, bending [GO:0044374]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; bacterial transcription [GO:0001121]; chromatin organization involved in regulation of transcription [GO:0034401]; positive regulation of DNA recombination [GO:0045911]; provirus excision [GO:0032359]; regulation of transcription, DNA-templated [GO:0006355]; response to radiation [GO:0009314] bacterial-type RNA polymerase core promoter sequence-specific DNA binding [GO:0000985]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription repressor activity [GO:0001217]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]; sequence-specific DNA binding, bending [GO:0044374]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000786; GO:0000976; GO:0000985; GO:0001121; GO:0001216; GO:0001217; GO:0003677; GO:0005829; GO:0006355; GO:0009295; GO:0009314; GO:0031421; GO:0032359; GO:0032993; GO:0034401; GO:0042803; GO:0043565; GO:0044374; GO:0045911 SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000269|PubMed:21903814}. Note=Scattered throughout the nucleoid (PubMed:21903814). {ECO:0000269|PubMed:21903814}. +P16869 FHUE_ECOLI FhuE receptor (Outer-membrane receptor for Fe(III)-coprogen, Fe(III)-ferrioxamine B and Fe(III)-rhodotrulic acid) fhuE b1102 JW1088 fhuE 81,233 iron ion homeostasis [GO:0055072] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; siderophore uptake transmembrane transporter activity [GO:0015344]; signaling receptor activity [GO:0038023]; iron ion homeostasis [GO:0055072] siderophore uptake transmembrane transporter activity [GO:0015344]; signaling receptor activity [GO:0038023] GO:0009279; GO:0015344; GO:0016021; GO:0038023; GO:0055072 SUBCELLULAR LOCATION: Cell outer membrane. +P39264 FIMI_ECOLI Fimbrin-like protein FimI fimI b4315 JW5779 fimI 19,373 cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus assembly [GO:0009297]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus assembly [GO:0009297]; pilus organization [GO:0043711] GO:0009289; GO:0009297; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. +P25437 FRMA_ECOLI S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284) (Alcohol dehydrogenase class-3) (EC 1.1.1.1) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) frmA adhC b0356 JW0347 adhC frmA 39,359 ethanol oxidation [GO:0006069]; formaldehyde catabolic process [GO:0046294] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; identical protein binding [GO:0042802]; S-(hydroxymethyl)glutathione dehydrogenase activity [GO:0051903]; S-(hydroxymethyl)glutathione dehydrogenase NAD activity [GO:0106322]; S-(hydroxymethyl)glutathione dehydrogenase NADP activity [GO:0106321]; zinc ion binding [GO:0008270]; ethanol oxidation [GO:0006069]; formaldehyde catabolic process [GO:0046294] alcohol dehydrogenase activity, zinc-dependent [GO:0004024]; identical protein binding [GO:0042802]; S-(hydroxymethyl)glutathione dehydrogenase activity [GO:0051903]; S-(hydroxymethyl)glutathione dehydrogenase NAD activity [GO:0106322]; S-(hydroxymethyl)glutathione dehydrogenase NADP activity [GO:0106321]; zinc ion binding [GO:0008270] GO:0004024; GO:0005737; GO:0005829; GO:0006069; GO:0008270; GO:0042802; GO:0046294; GO:0051903; GO:0106321; GO:0106322 SUBCELLULAR LOCATION: Cytoplasm. +P23910 ARAJ_ECOLI Putative transporter AraJ araJ b0396 JW0386 araJ 41,926 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P0AF08 APBC_ECOLI Iron-sulfur cluster carrier protein mrp b2113 JW2100 mrp 39,938 iron-sulfur cluster assembly [GO:0016226] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; iron-sulfur cluster assembly [GO:0016226] 4 iron, 4 sulfur cluster binding [GO:0051539]; ATPase activity [GO:0016887]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872] GO:0005524; GO:0005829; GO:0016226; GO:0016787; GO:0016887; GO:0046872; GO:0051539 +P26459 APPC_ECOLI Cytochrome bd-II ubiquinol oxidase subunit 1 (EC 7.1.1.3) (Cytochrome bd-II oxidase subunit I) appC cbdA cyxA b0978 JW0960 cbdA cyxA appC 57,920 aerobic electron transport chain [GO:0019646]; oxidative phosphorylation [GO:0006119] cytochrome complex [GO:0070069]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] cytochrome complex [GO:0070069]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cytochrome bo3 ubiquinol oxidase activity [GO:0009486]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [GO:0016682]; aerobic electron transport chain [GO:0019646]; oxidative phosphorylation [GO:0006119] cytochrome bo3 ubiquinol oxidase activity [GO:0009486]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [GO:0016682] GO:0005886; GO:0006119; GO:0009055; GO:0009486; GO:0016020; GO:0016021; GO:0016682; GO:0019646; GO:0020037; GO:0046872; GO:0070069 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P37028 BTUF_ECOLI Vitamin B12-binding protein btuF yadT b0158 JW0154 yadT btuF 29,367 cobalamin transport [GO:0015889] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; cobalamin binding [GO:0031419]; cobalamin transport [GO:0015889] cobalamin binding [GO:0031419] GO:0015889; GO:0030288; GO:0031419; GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_01000, ECO:0000269|PubMed:11790740}. +P20099 BISC_ECOLI Biotin sulfoxide reductase (BDS reductase) (BSO reductase) (EC 1.-.-.-) (L-methionine-(S)-sulfoxide reductase) (Met-S-SO reductase) (EC 1.8.4.13) bisC b3551 JW5940 bisC 85,851 anaerobic respiration [GO:0009061] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; electron transfer activity [GO:0009055]; L-methionine:thioredoxin-disulfide S-oxidoreductase activity [GO:0033744]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; anaerobic respiration [GO:0009061] electron transfer activity [GO:0009055]; L-methionine:thioredoxin-disulfide S-oxidoreductase activity [GO:0033744]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546] GO:0009055; GO:0009061; GO:0030151; GO:0030288; GO:0033744; GO:0043546 +P0ABN5 DCUA_ECOLI Anaerobic C4-dicarboxylate transporter DcuA dcuA genA b4138 JW5735 genA dcuA 45,751 C4-dicarboxylate transport [GO:0015740]; cellular nitrogen compound biosynthetic process [GO:0044271]; L-aspartate import across plasma membrane [GO:0140009] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; C4-dicarboxylate transmembrane transporter activity [GO:0015556]; succinate:fumarate antiporter activity [GO:0005469]; C4-dicarboxylate transport [GO:0015740]; cellular nitrogen compound biosynthetic process [GO:0044271]; L-aspartate import across plasma membrane [GO:0140009] C4-dicarboxylate transmembrane transporter activity [GO:0015556]; succinate:fumarate antiporter activity [GO:0005469] GO:0005469; GO:0005886; GO:0005887; GO:0015556; GO:0015740; GO:0044271; GO:0140009 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76251 DMLA_ECOLI D-malate dehydrogenase [decarboxylating] (EC 1.1.1.83) (D-malate degradation protein A) (D-malate oxidase) dmlA yeaU b1800 JW1789 yeaU dmlA 40,315 malate metabolic process [GO:0006108] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 3-isopropylmalate dehydrogenase activity [GO:0003862]; D-malate dehydrogenase (decarboxylating) activity [GO:0046553]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; tartrate dehydrogenase activity [GO:0009027]; malate metabolic process [GO:0006108] 3-isopropylmalate dehydrogenase activity [GO:0003862]; D-malate dehydrogenase (decarboxylating) activity [GO:0046553]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; tartrate dehydrogenase activity [GO:0009027] GO:0000287; GO:0003862; GO:0005737; GO:0006108; GO:0009027; GO:0046553; GO:0051287 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P0ACK5 DEOR_ECOLI Deoxyribose operon repressor deoR nucR b0840 JW0824 nucR deoR 28,548 negative regulation of DNA-templated transcription, initiation [GO:2000143] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of DNA-templated transcription, initiation [GO:2000143] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700] GO:0000986; GO:0003700; GO:2000143 +P77302 DGCM_ECOLI Diguanylate cyclase DgcM (DGC) (EC 2.7.7.65) dgcM ydaM b1341 JW5206 ydaM dgcM 46,452 cell adhesion involved in single-species biofilm formation [GO:0043709]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of single-species biofilm formation on inanimate substrate [GO:1900233] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; cell adhesion involved in single-species biofilm formation [GO:0043709]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of single-species biofilm formation on inanimate substrate [GO:1900233] diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] GO:0005525; GO:0005886; GO:0042802; GO:0043709; GO:0046872; GO:0051091; GO:0052621; GO:1900233; GO:1902201 +P23847 DPPA_ECOLI Dipeptide-binding protein (DBP) (Periplasmic dipeptide transport protein) dppA b3544 JW3513 dppA 60,294 chaperone-mediated protein folding [GO:0061077]; chemotaxis [GO:0006935]; dipeptide transport [GO:0042938]; peptide transport [GO:0015833]; protein transport [GO:0015031] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288]; dipeptide transmembrane transporter activity [GO:0071916]; heme binding [GO:0020037]; peptide binding [GO:0042277]; peptide transmembrane transporter activity [GO:1904680]; chaperone-mediated protein folding [GO:0061077]; chemotaxis [GO:0006935]; dipeptide transport [GO:0042938]; peptide transport [GO:0015833]; protein transport [GO:0015031] dipeptide transmembrane transporter activity [GO:0071916]; heme binding [GO:0020037]; peptide binding [GO:0042277]; peptide transmembrane transporter activity [GO:1904680] GO:0006935; GO:0015031; GO:0015833; GO:0020037; GO:0030288; GO:0042277; GO:0042938; GO:0043190; GO:0061077; GO:0071916; GO:1904680 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:1702779}. +P08192 FOLC_ECOLI Dihydrofolate synthase/folylpolyglutamate synthase (DHFS / FPGS) (EC 6.3.2.12) (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase) (Folylpolyglutamate synthetase) (Tetrahydrofolylpolyglutamate synthase) folC dedC b2315 JW2312 dedC folC 45,406 folic acid biosynthetic process [GO:0046656]; folic acid-containing compound biosynthetic process [GO:0009396]; one-carbon metabolic process [GO:0006730]; tetrahydrofolate biosynthetic process [GO:0046654] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; dihydrofolate synthase activity [GO:0008841]; metal ion binding [GO:0046872]; tetrahydrofolylpolyglutamate synthase activity [GO:0004326]; folic acid biosynthetic process [GO:0046656]; folic acid-containing compound biosynthetic process [GO:0009396]; one-carbon metabolic process [GO:0006730]; tetrahydrofolate biosynthetic process [GO:0046654] ATP binding [GO:0005524]; dihydrofolate synthase activity [GO:0008841]; metal ion binding [GO:0046872]; tetrahydrofolylpolyglutamate synthase activity [GO:0004326] GO:0004326; GO:0005524; GO:0005737; GO:0006730; GO:0008841; GO:0009396; GO:0046654; GO:0046656; GO:0046872 +P43533 FLGN_ECOLI Flagella synthesis protein FlgN flgN b1070 JW1057 flgN 15,867 bacterial-type flagellum assembly [GO:0044780] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; bacterial-type flagellum assembly [GO:0044780] GO:0005737; GO:0044780 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P31574 FIXB_ECOLI Protein FixB fixB yaaR b0042 JW0041 yaaR fixB 33,513 carnitine catabolic process [GO:0042413]; carnitine metabolic process [GO:0009437]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539] electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; carnitine catabolic process [GO:0042413]; carnitine metabolic process [GO:0009437]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539] electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660] GO:0009055; GO:0009437; GO:0033539; GO:0042413; GO:0050660 +P0AC33 FUMA_ECOLI Fumarate hydratase class I, aerobic (EC 4.2.1.2) (Fumarase A) (Oxaloacetate keto--enol-isomerase) (OAAKE isomerase) (Oxaloacetate tautomerase) (EC 5.3.2.2) fumA b1612 JW1604 fumA 60,299 tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; fumarate hydratase activity [GO:0004333]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxaloacetate tautomerase activity [GO:0050163]; tricarboxylic acid cycle [GO:0006099] 4 iron, 4 sulfur cluster binding [GO:0051539]; fumarate hydratase activity [GO:0004333]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxaloacetate tautomerase activity [GO:0050163] GO:0004333; GO:0005829; GO:0006099; GO:0042802; GO:0046872; GO:0050163; GO:0051539 +P05825 FEPA_ECOLI Ferrienterobactin receptor (Enterobactin outer-membrane receptor) fepA fep feuB b0584 JW5086 fep feuB fepA 82,107 colicin transport [GO:0042914]; enterobactin transport [GO:0042930]; ferric-enterobactin import into cell [GO:0015685]; siderophore-dependent iron import into cell [GO:0033214]; siderophore transmembrane transport [GO:0044718] cell envelope [GO:0030313]; cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; intrinsic component of cell outer membrane [GO:0031230] cell envelope [GO:0030313]; cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; intrinsic component of cell outer membrane [GO:0031230]; colicin transmembrane transporter activity [GO:0042912]; enterobactin transmembrane transporter activity [GO:0042931]; ferric-enterobactin transmembrane transporter activity [GO:0015620]; ligand-gated channel activity [GO:0022834]; protein domain specific binding [GO:0019904]; siderophore uptake transmembrane transporter activity [GO:0015344]; signaling receptor activity [GO:0038023]; colicin transport [GO:0042914]; enterobactin transport [GO:0042930]; ferric-enterobactin import into cell [GO:0015685]; siderophore transmembrane transport [GO:0044718]; siderophore-dependent iron import into cell [GO:0033214] colicin transmembrane transporter activity [GO:0042912]; enterobactin transmembrane transporter activity [GO:0042931]; ferric-enterobactin transmembrane transporter activity [GO:0015620]; ligand-gated channel activity [GO:0022834]; protein domain specific binding [GO:0019904]; siderophore uptake transmembrane transporter activity [GO:0015344]; signaling receptor activity [GO:0038023] GO:0009279; GO:0015344; GO:0015620; GO:0015685; GO:0019904; GO:0022834; GO:0030313; GO:0031230; GO:0033214; GO:0038023; GO:0042912; GO:0042914; GO:0042930; GO:0042931; GO:0044718; GO:0045203 SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein. +P25526 GABD_ECOLI Succinate-semialdehyde dehydrogenase [NADP(+)] GabD (SSDH) (EC 1.2.1.79) (Glutarate-semialdehyde dehydrogenase) (EC 1.2.1.-) gabD b2661 JW2636 gabD 51,720 gamma-aminobutyric acid catabolic process [GO:0009450]; nitrogen compound metabolic process [GO:0006807]; protein homotetramerization [GO:0051289] glutarate-semialdehyde dehydrogenase (NADP+) activity [GO:0102810]; NADP binding [GO:0050661]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777]; succinate-semialdehyde dehydrogenase (NADP+) activity [GO:0036243]; succinate-semialdehyde dehydrogenase [NAD(P)+] activity [GO:0009013]; gamma-aminobutyric acid catabolic process [GO:0009450]; nitrogen compound metabolic process [GO:0006807]; protein homotetramerization [GO:0051289] glutarate-semialdehyde dehydrogenase (NADP+) activity [GO:0102810]; NADP binding [GO:0050661]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777]; succinate-semialdehyde dehydrogenase (NADP+) activity [GO:0036243]; succinate-semialdehyde dehydrogenase [NAD(P)+] activity [GO:0009013] GO:0004777; GO:0006807; GO:0009013; GO:0009450; GO:0036243; GO:0050661; GO:0051289; GO:0102810 +P76518 ACOCT_ECOLI Acetyl-CoA:oxalate CoA-transferase (ACOCT) (EC 2.8.3.19) (Acetyl-coenzyme A transferase) (CoA:oxalate CoA-transferase) yfdE b2371 JW2368 yfdE 41,671 acetyl-CoA:oxalate CoA-transferase [GO:0036412] acetyl-CoA:oxalate CoA-transferase [GO:0036412] GO:0036412 +P76464 A2MGH_ECOLI Putative alpha-2-macroglobulin homolog yfaS yfaR b4500 JW2221/JW2222 b2227/b2228 yfaR yfaS 151,114 endopeptidase inhibitor activity [GO:0004866] endopeptidase inhibitor activity [GO:0004866] GO:0004866 +P77731 ALLA_ECOLI Ureidoglycolate lyase (EC 4.3.2.3) (Ureidoglycolatase) (Ureidoglycolate hydrolase) allA glxA2 ybbT b0505 JW0493 glxA2 ybbT allA 18,170 allantoin catabolic process [GO:0000256]; purine nucleobase catabolic process [GO:0006145] ureidoglycolate hydrolase activity [GO:0004848]; ureidoglycolate lyase activity [GO:0050385]; allantoin catabolic process [GO:0000256]; purine nucleobase catabolic process [GO:0006145] ureidoglycolate hydrolase activity [GO:0004848]; ureidoglycolate lyase activity [GO:0050385] GO:0000256; GO:0004848; GO:0006145; GO:0050385 +P36548 AMIA_ECOLI N-acetylmuramoyl-L-alanine amidase AmiA (EC 3.5.1.28) amiA yfeE b2435 JW2428 yfeE amiA 31,412 cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; zinc ion binding [GO:0008270]; cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253] N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; zinc ion binding [GO:0008270] GO:0008270; GO:0008745; GO:0009253; GO:0030288; GO:0042597; GO:0071555 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:12787347}. Note=Distributed throughout the periplasm in all cells. +P0AB71 ALF_ECOLI Fructose-bisphosphate aldolase class 2 (FBP aldolase) (FBPA) (EC 4.1.2.13) (Fructose-1,6-bisphosphate aldolase) (Fructose-bisphosphate aldolase class II) fbaA fba fda b2925 JW2892 fba fda fbaA 39,147 gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096] cytosol [GO:0005829] cytosol [GO:0005829]; fructose-bisphosphate aldolase activity [GO:0004332]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096] fructose-bisphosphate aldolase activity [GO:0004332]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] GO:0004332; GO:0005829; GO:0006094; GO:0006096; GO:0008270; GO:0042802 +P15770 AROE_ECOLI Shikimate dehydrogenase (NADP(+)) (SD) (SDH) (EC 1.1.1.25) aroE b3281 JW3242 aroE 29,414 aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423]; shikimate metabolic process [GO:0019632] cytosol [GO:0005829] cytosol [GO:0005829]; NADP binding [GO:0050661]; nucleotide binding [GO:0000166]; shikimate 3-dehydrogenase (NADP+) activity [GO:0004764]; aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423]; shikimate metabolic process [GO:0019632] NADP binding [GO:0050661]; nucleotide binding [GO:0000166]; shikimate 3-dehydrogenase (NADP+) activity [GO:0004764] GO:0000166; GO:0004764; GO:0005829; GO:0008652; GO:0009073; GO:0009423; GO:0019632; GO:0050661 +P77757 ARNC_ECOLI Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (EC 2.4.2.53) (Polymyxin resistance protein PmrF) (Undecaprenyl-phosphate Ara4FN transferase) (Ara4FN transferase) arnC pmrF yfbF b2254 JW2248 pmrF yfbF arnC 36,339 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process [GO:0036108]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; response to antibiotic [GO:0046677] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity [GO:0099621]; 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process [GO:0036108]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; response to antibiotic [GO:0046677] phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity [GO:0099621] GO:0005886; GO:0009103; GO:0009245; GO:0016020; GO:0016021; GO:0016780; GO:0036108; GO:0046677; GO:0099621 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P39334 BDCR_ECOLI HTH-type transcriptional repressor BdcR bdcR yjgJ b4251 JW4208 yjgJ bdcR 21,502 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355; GO:0045892 +P0A6E9 BIOD2_ECOLI ATP-dependent dethiobiotin synthetase BioD 2 (EC 6.3.3.3) (DTB synthetase 2) (DTBS 2) (Dethiobiotin synthase 2) bioD2 ynfK b1593 JW5264 ynfK bioD2 24,981 biotin biosynthetic process [GO:0009102] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; dethiobiotin synthase activity [GO:0004141]; magnesium ion binding [GO:0000287]; biotin biosynthetic process [GO:0009102] ATP binding [GO:0005524]; dethiobiotin synthase activity [GO:0004141]; magnesium ion binding [GO:0000287] GO:0000287; GO:0004141; GO:0005524; GO:0005829; GO:0009102 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00336}. +P05804 BGLR_ECOLI Beta-glucuronidase (GUS) (EC 3.2.1.31) (Beta-D-glucuronoside glucuronosohydrolase) uidA gurA gusA b1617 JW1609 gurA gusA uidA 68,447 glucuronoside catabolic process [GO:0019391] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; beta-glucuronidase activity [GO:0004566]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; glucuronoside catabolic process [GO:0019391] beta-glucuronidase activity [GO:0004566]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802] GO:0004566; GO:0005829; GO:0019391; GO:0030246; GO:0032991; GO:0042802 +P69853 DMSD_ECOLI Tat proofreading chaperone DmsD (DMSO reductase maturation protein) (Twin-arginine leader-binding protein DmsD) dmsD ynfI b1591 JW5262 ynfI dmsD 23,345 chaperone-mediated protein folding [GO:0061077] cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234] cytoplasm [GO:0005737]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; signal sequence binding [GO:0005048]; chaperone-mediated protein folding [GO:0061077] signal sequence binding [GO:0005048] GO:0005048; GO:0005737; GO:0031234; GO:0061077 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:12813051}; Peripheral membrane protein {ECO:0000269|PubMed:12813051}. Cytoplasm {ECO:0000269|PubMed:12813051}. Note=Mainly cytoplasmic under aerobic conditions, and found in the inner membrane under anaerobic conditions. +P0AEG6 DSBC_ECOLI Thiol:disulfide interchange protein DsbC dsbC xprA b2893 JW2861 xprA dsbC 25,622 chaperone-mediated protein folding [GO:0061077]; response to copper ion [GO:0046688] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; protein disulfide isomerase activity [GO:0003756]; protein disulfide oxidoreductase activity [GO:0015035]; chaperone-mediated protein folding [GO:0061077]; response to copper ion [GO:0046688] protein disulfide isomerase activity [GO:0003756]; protein disulfide oxidoreductase activity [GO:0015035] GO:0003756; GO:0015035; GO:0030288; GO:0042597; GO:0046688; GO:0061077 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:8168498}. +P23895 EMRE_ECOLI Multidrug transporter EmrE (Efflux-multidrug resistance protein EmrE) (Ethidium resistance protein) (Methyl viologen resistance protein C) emrE eb mvrC b0543 JW0531 eb mvrC emrE 11,958 cellular response to DNA damage stimulus [GO:0006974]; choline transport [GO:0015871]; glycine betaine transport [GO:0031460]; response to drug [GO:0042493]; response to osmotic stress [GO:0006970]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; amino-acid betaine transmembrane transporter activity [GO:0015199]; antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; identical protein binding [GO:0042802]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]; cellular response to DNA damage stimulus [GO:0006974]; choline transport [GO:0015871]; glycine betaine transport [GO:0031460]; response to drug [GO:0042493]; response to osmotic stress [GO:0006970]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908] amino-acid betaine transmembrane transporter activity [GO:0015199]; antiporter activity [GO:0015297]; choline transmembrane transporter activity [GO:0015220]; identical protein binding [GO:0042802]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0005887; GO:0006805; GO:0006970; GO:0006974; GO:0015199; GO:0015220; GO:0015297; GO:0015871; GO:0016020; GO:0016021; GO:0022857; GO:0031460; GO:0042493; GO:0042802; GO:0042908; GO:0042910; GO:0055085; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15044024, ECO:0000269|PubMed:9688273}; Multi-pass membrane protein {ECO:0000269|PubMed:15044024, ECO:0000269|PubMed:17005200, ECO:0000269|PubMed:9688273}. Note=Forms antiparallel homodimers (PubMed:17005200, PubMed:18024586, PubMed:20508091, PubMed:20551331, PubMed:22178925, PubMed:23920359). The topology could be controlled by a single positively charged residue placed in different locations throughout the protein, including the very C terminus (PubMed:20508091). {ECO:0000269|PubMed:17005200, ECO:0000269|PubMed:18024586, ECO:0000269|PubMed:20508091, ECO:0000269|PubMed:20551331, ECO:0000269|PubMed:22178925, ECO:0000269|PubMed:23920359}. +P31119 AAS_ECOLI Bifunctional protein Aas [Includes: 2-acylglycerophosphoethanolamine acyltransferase (EC 2.3.1.40) (2-acyl-GPE acyltransferase) (Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase); Acyl-[acyl-carrier-protein] synthetase (EC 6.2.1.20) (Acyl-ACP synthetase) (Long-chain-fatty-acid--[acyl-carrier-protein] ligase)] aas b2836 JW2804 aas 80,700 fatty acid metabolic process [GO:0006631]; phospholipid biosynthetic process [GO:0008654] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity [GO:0008779]; ATP binding [GO:0005524]; long-chain fatty acid [acyl-carrier-protein] ligase activity [GO:0008922]; long-chain fatty acid-CoA ligase activity [GO:0004467]; fatty acid metabolic process [GO:0006631]; phospholipid biosynthetic process [GO:0008654] acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity [GO:0008779]; ATP binding [GO:0005524]; long-chain fatty acid [acyl-carrier-protein] ligase activity [GO:0008922]; long-chain fatty acid-CoA ligase activity [GO:0004467] GO:0004467; GO:0005524; GO:0005886; GO:0006631; GO:0008654; GO:0008779; GO:0008922; GO:0016020; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P46478 AAEX_ECOLI Protein AaeX aaeX yhcR b3242 JW5541 yhcR aaeX 7,847 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01546}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01546}. +P31440 ADEQ_ECOLI Adenine permease AdeQ adeQ yicO b3664 JW5636 yicO adeQ 46,934 adenine transport [GO:0015853] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; adenine transmembrane transporter activity [GO:0015207]; purine nucleobase transmembrane transporter activity [GO:0005345]; adenine transport [GO:0015853] adenine transmembrane transporter activity [GO:0015207]; purine nucleobase transmembrane transporter activity [GO:0005345] GO:0005345; GO:0005886; GO:0005887; GO:0015207; GO:0015853 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:24214977}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:24214977}. +P26646 ACUI_ECOLI Probable acrylyl-CoA reductase AcuI (EC 1.3.1.84) (Acryloyl-coenzyme A reductase AcuI) acuI yhdH b3253 JW3222 yhdH acuI 34,724 cytoplasm [GO:0005737] cytoplasm [GO:0005737]; acryloyl-CoA reductase (NADP+) activity [GO:0043957] acryloyl-CoA reductase (NADP+) activity [GO:0043957] GO:0005737; GO:0043957 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P36675 ARFA_ECOLI Alternative ribosome-rescue factor A arfA yhdL b4550 JW3253 yhdL arfA 8,171 rescue of stalled ribosome [GO:0072344] ribosomal large subunit binding [GO:0043023]; rRNA binding [GO:0019843]; tRNA binding [GO:0000049]; rescue of stalled ribosome [GO:0072344] ribosomal large subunit binding [GO:0043023]; rRNA binding [GO:0019843]; tRNA binding [GO:0000049] GO:0000049; GO:0019843; GO:0043023; GO:0072344 +P11447 ARLY_ECOLI Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) argH b3960 JW3932 argH 50,318 arginine biosynthetic process via ornithine [GO:0042450] cytosol [GO:0005829] cytosol [GO:0005829]; argininosuccinate lyase activity [GO:0004056]; arginine biosynthetic process via ornithine [GO:0042450] argininosuccinate lyase activity [GO:0004056] GO:0004056; GO:0005829; GO:0042450 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P13016 AMPD_ECOLI 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD (EC 3.5.1.28) (N-acetylmuramoyl-L-alanine amidase) ampD b0110 JW0106 ampD 20,536 cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253]; peptidoglycan turnover [GO:0009254] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; N-acetyl-anhydromuramoyl-L-alanine amidase activity [GO:0009392]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253]; peptidoglycan turnover [GO:0009254] metal ion binding [GO:0046872]; N-acetyl-anhydromuramoyl-L-alanine amidase activity [GO:0009392]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745] GO:0005737; GO:0008745; GO:0009253; GO:0009254; GO:0009392; GO:0046872; GO:0071555 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:19309146}. +P76217 ASTD_ECOLI N-succinylglutamate 5-semialdehyde dehydrogenase (EC 1.2.1.71) (Succinylglutamic semialdehyde dehydrogenase) (SGSD) astD ydjU b1746 JW5282 ydjU astD 53,026 arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to succinate [GO:0019545] aldehyde dehydrogenase (NAD+) activity [GO:0004029]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777]; succinylglutamate-semialdehyde dehydrogenase activity [GO:0043824]; arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to succinate [GO:0019545] aldehyde dehydrogenase (NAD+) activity [GO:0004029]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777]; succinylglutamate-semialdehyde dehydrogenase activity [GO:0043824] GO:0004029; GO:0004777; GO:0019544; GO:0019545; GO:0043824 +P0A6D7 AROK_ECOLI Shikimate kinase 1 (SK 1) (EC 2.7.1.71) (Shikimate kinase I) (SKI) aroK b3390 JW5947 aroK 19,538 aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423]; response to antibiotic [GO:0046677] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; shikimate kinase activity [GO:0004765]; aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423]; response to antibiotic [GO:0046677] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; shikimate kinase activity [GO:0004765] GO:0000287; GO:0004765; GO:0005524; GO:0005829; GO:0008652; GO:0009073; GO:0009423; GO:0046677 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0ABA4 ATPD_ECOLI ATP synthase subunit delta (ATP synthase F(1) sector subunit delta) (F-type ATPase subunit delta) (F-ATPase subunit delta) atpH papE uncH b3735 JW3713 papE uncH atpH 19,332 ATP synthesis coupled proton transport [GO:0015986] plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261] plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP synthesis coupled proton transport [GO:0015986] proton-transporting ATPase activity, rotational mechanism [GO:0046961]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933] GO:0005886; GO:0015986; GO:0045261; GO:0046933; GO:0046961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01416, ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01416, ECO:0000269|PubMed:16079137}. +P17446 BETI_ECOLI HTH-type transcriptional regulator BetI betI b0313 JW0305 betI 21,815 glycine betaine biosynthetic process from choline [GO:0019285]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; response to osmotic stress [GO:0006970] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; glycine betaine biosynthetic process from choline [GO:0019285]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; response to osmotic stress [GO:0006970] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003677; GO:0003700; GO:0006355; GO:0006970; GO:0019285; GO:0045892 +P77744 ABGR_ECOLI HTH-type transcriptional regulator AbgR abgR b1339 JW1333 abgR 34,058 regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355 +P24224 ACPS_ECOLI Holo-[acyl-carrier-protein] synthase (Holo-ACP synthase) (EC 2.7.8.7) (4'-phosphopantetheinyl transferase AcpS) acpS dpj b2563 JW2547 dpj acpS 14,052 fatty acid biosynthetic process [GO:0006633]; peptidyl-serine phosphopantetheinylation [GO:0018070] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; holo-[acyl-carrier-protein] synthase activity [GO:0008897]; magnesium ion binding [GO:0000287]; transferase activity [GO:0016740]; fatty acid biosynthetic process [GO:0006633]; peptidyl-serine phosphopantetheinylation [GO:0018070] holo-[acyl-carrier-protein] synthase activity [GO:0008897]; magnesium ion binding [GO:0000287]; transferase activity [GO:0016740] GO:0000287; GO:0005737; GO:0006633; GO:0008897; GO:0016740; GO:0018070 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AB96 ARSC_ECOLI Arsenate reductase (EC 1.20.4.1) (Arsenical pump modifier) arsC arsG b3503 JW3470 arsG arsC 15,853 cellular response to DNA damage stimulus [GO:0006974]; response to arsenic-containing substance [GO:0046685] arsenate reductase (glutaredoxin) activity [GO:0008794]; cellular response to DNA damage stimulus [GO:0006974]; response to arsenic-containing substance [GO:0046685] arsenate reductase (glutaredoxin) activity [GO:0008794] GO:0006974; GO:0008794; GO:0046685 +P0A9H5 BTUR_ECOLI Corrinoid adenosyltransferase (EC 2.5.1.17) (Cob(II)alamin adenosyltransferase) (Cob(II)yrinic acid a,c-diamide adenosyltransferase) (Cobinamide/cobalamin adenosyltransferase) btuR cobA b1270 JW1262 cobA btuR 21,999 aerobic cobalamin biosynthetic process [GO:0019250]; cobalamin biosynthetic process [GO:0009236]; porphyrin-containing compound biosynthetic process [GO:0006779] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; cob(I)yrinic acid a,c-diamide adenosyltransferase activity [GO:0008817]; aerobic cobalamin biosynthetic process [GO:0019250]; cobalamin biosynthetic process [GO:0009236]; porphyrin-containing compound biosynthetic process [GO:0006779] ATP binding [GO:0005524]; cob(I)yrinic acid a,c-diamide adenosyltransferase activity [GO:0008817] GO:0005524; GO:0005737; GO:0006779; GO:0008817; GO:0009236; GO:0019250 SUBCELLULAR LOCATION: Cytoplasm. +P06709 BIRA_ECOLI Bifunctional ligase/repressor BirA (Biotin operon repressor) (Biotin--[acetyl-CoA-carboxylase] ligase) (EC 6.3.4.15) (Biotin--protein ligase) (Biotin-[acetyl-CoA carboxylase] synthetase) birA bioR dhbB b3973 JW3941 bioR dhbB birA 35,312 biotin biosynthetic process [GO:0009102]; biotin metabolic process [GO:0006768]; protein biotinylation [GO:0009305]; regulation of transcription, DNA-templated [GO:0006355] cytoplasm [GO:0005737]; transcription repressor complex [GO:0017053] cytoplasm [GO:0005737]; transcription repressor complex [GO:0017053]; ATP binding [GO:0005524]; bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding [GO:0000984]; biotin binding [GO:0009374]; biotin-[acetyl-CoA-carboxylase] ligase activity [GO:0004077]; DNA binding [GO:0003677]; protein homodimerization activity [GO:0042803]; biotin biosynthetic process [GO:0009102]; biotin metabolic process [GO:0006768]; protein biotinylation [GO:0009305]; regulation of transcription, DNA-templated [GO:0006355] ATP binding [GO:0005524]; bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding [GO:0000984]; biotin-[acetyl-CoA-carboxylase] ligase activity [GO:0004077]; biotin binding [GO:0009374]; DNA binding [GO:0003677]; protein homodimerization activity [GO:0042803] GO:0000984; GO:0003677; GO:0004077; GO:0005524; GO:0005737; GO:0006355; GO:0006768; GO:0009102; GO:0009305; GO:0009374; GO:0017053; GO:0042803 +P60584 CAIA_ECOLI Crotonobetainyl-CoA reductase (EC 1.3.8.13) (Crotobetaine reductase) (Crotonobetainyl-CoA dehydrogenase) caiA yaaO b0039 JW0038 yaaO caiA 42,558 carnitine metabolic process [GO:0009437] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [GO:0052890]; carnitine metabolic process [GO:0009437] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [GO:0052890] GO:0003995; GO:0005737; GO:0009437; GO:0050660; GO:0052890 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01052, ECO:0000269|PubMed:8060125}. +P0A964 CHEW_ECOLI Chemotaxis protein CheW cheW b1887 JW1876 cheW 18,084 aerotaxis [GO:0009454]; chemotaxis [GO:0006935]; establishment of localization in cell [GO:0051649]; positive regulation of post-translational protein modification [GO:1901875]; positive regulation of protein histidine kinase activity [GO:0010864]; signal transduction [GO:0007165] cell tip [GO:0051286]; cytosol [GO:0005829]; methyl accepting chemotaxis protein complex [GO:0098561]; plasma membrane [GO:0005886] cell tip [GO:0051286]; cytosol [GO:0005829]; methyl accepting chemotaxis protein complex [GO:0098561]; plasma membrane [GO:0005886]; protein domain specific binding [GO:0019904]; aerotaxis [GO:0009454]; chemotaxis [GO:0006935]; establishment of localization in cell [GO:0051649]; positive regulation of post-translational protein modification [GO:1901875]; positive regulation of protein histidine kinase activity [GO:0010864]; signal transduction [GO:0007165] protein domain specific binding [GO:0019904] GO:0005829; GO:0005886; GO:0006935; GO:0007165; GO:0009454; GO:0010864; GO:0019904; GO:0051286; GO:0051649; GO:0098561; GO:1901875 SUBCELLULAR LOCATION: Cytoplasm. +P30863 DKGB_ECOLI 2,5-diketo-D-gluconic acid reductase B (2,5-DKG reductase B) (2,5-DKGR B) (25DKGR-B) (EC 1.1.1.346) (AKR5D) dkgB yafB b0207 JW0197 yafB dkgB 29,437 L-ascorbic acid biosynthetic process [GO:0019853]; methylglyoxal catabolic process [GO:0051596] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; aldo-keto reductase (NADP) activity [GO:0004033]; aryl-alcohol dehydrogenase (NADP+) activity [GO:0047681]; D-threo-aldose 1-dehydrogenase activity [GO:0047834]; methylglyoxal reductase (NADPH-dependent, acetol producing) [GO:1990002]; L-ascorbic acid biosynthetic process [GO:0019853]; methylglyoxal catabolic process [GO:0051596] aldo-keto reductase (NADP) activity [GO:0004033]; aryl-alcohol dehydrogenase (NADP+) activity [GO:0047681]; D-threo-aldose 1-dehydrogenase activity [GO:0047834]; methylglyoxal reductase (NADPH-dependent, acetol producing) [GO:1990002] GO:0004033; GO:0005737; GO:0019853; GO:0047681; GO:0047834; GO:0051596; GO:1990002 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P0A6L0 DEOC_ECOLI Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase) deoC dra thyR b4381 JW4344 dra thyR deoC 27,734 carbohydrate catabolic process [GO:0016052]; cellular response to DNA damage stimulus [GO:0006974]; deoxyribonucleotide catabolic process [GO:0009264]; deoxyribose phosphate catabolic process [GO:0046386]; nucleobase-containing small molecule interconversion [GO:0015949] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; deoxyribose-phosphate aldolase activity [GO:0004139]; lyase activity [GO:0016829]; carbohydrate catabolic process [GO:0016052]; cellular response to DNA damage stimulus [GO:0006974]; deoxyribonucleotide catabolic process [GO:0009264]; deoxyribose phosphate catabolic process [GO:0046386]; nucleobase-containing small molecule interconversion [GO:0015949] deoxyribose-phosphate aldolase activity [GO:0004139]; lyase activity [GO:0016829] GO:0004139; GO:0005829; GO:0006974; GO:0009264; GO:0015949; GO:0016020; GO:0016052; GO:0016829; GO:0046386 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00592, ECO:0000305}. +P45568 DXR_ECOLI 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXP reductoisomerase) (EC 1.1.1.267) (1-deoxyxylulose-5-phosphate reductoisomerase) (2-C-methyl-D-erythritol 4-phosphate synthase) dxr ispC yaeM b0173 JW0168 ispC yaeM dxr 43,388 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process [GO:0051484] 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity [GO:0030604]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; NADPH binding [GO:0070402]; isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process [GO:0051484] 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity [GO:0030604]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; NADPH binding [GO:0070402] GO:0019288; GO:0030145; GO:0030604; GO:0042802; GO:0051484; GO:0070402 +P52600 EMRY_ECOLI Probable multidrug resistance protein EmrY emrY b2367 JW2364 emrY 56,001 bile acid and bile salt transport [GO:0015721]; cellular response to DNA damage stimulus [GO:0006974]; response to antibiotic [GO:0046677]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; bile acid and bile salt transport [GO:0015721]; cellular response to DNA damage stimulus [GO:0006974]; response to antibiotic [GO:0046677]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0006974; GO:0015721; GO:0022857; GO:0046677; GO:0055085; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P52697 6PGL_ECOLI 6-phosphogluconolactonase (6-P-gluconolactonase) (Pgl) (EC 3.1.1.31) pgl ybhE b0767 JW0750 ybhE pgl 36,308 glucose metabolic process [GO:0006006]; pentose-phosphate shunt [GO:0006098] cytosol [GO:0005829] cytosol [GO:0005829]; 6-phosphogluconolactonase activity [GO:0017057]; glucose metabolic process [GO:0006006]; pentose-phosphate shunt [GO:0006098] 6-phosphogluconolactonase activity [GO:0017057] GO:0005829; GO:0006006; GO:0006098; GO:0017057 +P35340 AHPF_ECOLI Alkyl hydroperoxide reductase subunit F (EC 1.8.1.-) (Alkyl hydroperoxide reductase F52A protein) ahpF b0606 JW0599 ahpF 56,177 response to reactive oxygen species [GO:0000302] alkyl hydroperoxide reductase complex [GO:0009321]; cytosol [GO:0005829] alkyl hydroperoxide reductase complex [GO:0009321]; cytosol [GO:0005829]; alkyl hydroperoxide reductase activity [GO:0008785]; FAD binding [GO:0071949]; NAD binding [GO:0051287]; protein disulfide oxidoreductase activity [GO:0015035]; response to reactive oxygen species [GO:0000302] alkyl hydroperoxide reductase activity [GO:0008785]; FAD binding [GO:0071949]; NAD binding [GO:0051287]; protein disulfide oxidoreductase activity [GO:0015035] GO:0000302; GO:0005829; GO:0008785; GO:0009321; GO:0015035; GO:0051287; GO:0071949 +P77671 ALLB_ECOLI Allantoinase (EC 3.5.2.5) (Allantoin-utilizing enzyme) allB glxB3 ybbX b0512 JW0500 glxB3 ybbX allB 49,602 allantoin assimilation pathway [GO:0009442]; purine nucleobase catabolic process [GO:0006145] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; allantoinase activity [GO:0004038]; cobalt ion binding [GO:0050897]; zinc ion binding [GO:0008270]; allantoin assimilation pathway [GO:0009442]; purine nucleobase catabolic process [GO:0006145] allantoinase activity [GO:0004038]; cobalt ion binding [GO:0050897]; zinc ion binding [GO:0008270] GO:0004038; GO:0005737; GO:0006145; GO:0008270; GO:0009442; GO:0050897 +P75681 AFUB_ECOLI Putative ferric transport system permease-like protein AfuB afuB fbpB b0263 JW0255 fbpB afuB 13,093 transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transport [GO:0055085] GO:0005886; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein. Note=When overexpressed using vectors that provide a promoter and ribosome binding site (PubMed:15919996). {ECO:0000269|PubMed:15919996}. +P06720 AGAL_ECOLI Alpha-galactosidase (EC 3.2.1.22) (Melibiase) melA mel-7 b4119 JW4080 mel-7 melA 50,657 melibiose catabolic process [GO:0005995] cytosol [GO:0005829] cytosol [GO:0005829]; alpha-galactosidase activity [GO:0004557]; manganese ion binding [GO:0030145]; NAD+ binding [GO:0070403]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; raffinose alpha-galactosidase activity [GO:0052692]; melibiose catabolic process [GO:0005995] alpha-galactosidase activity [GO:0004557]; manganese ion binding [GO:0030145]; NAD+ binding [GO:0070403]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; raffinose alpha-galactosidase activity [GO:0052692] GO:0004557; GO:0005829; GO:0005995; GO:0016616; GO:0030145; GO:0052692; GO:0070403 +P0AAF3 ARAG_ECOLI Arabinose import ATP-binding protein AraG (EC 7.5.2.12) araG b1900 JW1888 araG 55,018 L-arabinose transmembrane transport [GO:0042882] cytosol [GO:0005829]; plasma membrane [GO:0005886] cytosol [GO:0005829]; plasma membrane [GO:0005886]; ABC-type L-arabinose transporter activity [GO:0015612]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; L-arabinose transmembrane transport [GO:0042882] ABC-type L-arabinose transporter activity [GO:0015612]; ATPase activity [GO:0016887]; ATP binding [GO:0005524] GO:0005524; GO:0005829; GO:0005886; GO:0015612; GO:0016887; GO:0042882 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01721, ECO:0000269|PubMed:7028715}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01721, ECO:0000269|PubMed:7028715}. +P62672 APAG_ECOLI Protein ApaG apaG b0050 JW0049 apaG 13,867 error-free translesion synthesis [GO:0070987] error-free translesion synthesis [GO:0070987] GO:0070987 +P0A6E1 AROL_ECOLI Shikimate kinase 2 (SK 2) (EC 2.7.1.71) (Shikimate kinase II) (SKII) aroL b0388 JW0379 aroL 19,151 aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; shikimate kinase activity [GO:0004765]; aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; shikimate kinase activity [GO:0004765] GO:0000287; GO:0004765; GO:0005524; GO:0005829; GO:0008652; GO:0009073; GO:0009423; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P0ABA6 ATPG_ECOLI ATP synthase gamma chain (ATP synthase F1 sector gamma subunit) (F-ATPase gamma subunit) atpG papC uncG b3733 JW3711 papC uncG atpG 31,577 ATP synthesis coupled proton transport [GO:0015986]; plasma membrane ATP synthesis coupled proton transport [GO:0042777] membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261] membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; ATP binding [GO:0005524]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP synthesis coupled proton transport [GO:0015986]; plasma membrane ATP synthesis coupled proton transport [GO:0042777] ATP binding [GO:0005524]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933] GO:0005524; GO:0005886; GO:0015986; GO:0016020; GO:0042777; GO:0045261; GO:0046933; GO:0046961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000269|PubMed:16079137}. +P76461 ATOB_ECOLI Acetyl-CoA acetyltransferase (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) atoB b2224 JW2218 atoB 40,352 acetoacetic acid catabolic process [GO:0043442]; fatty acid beta-oxidation [GO:0006635] cytoplasm [GO:0005737]; protein-containing complex [GO:0032991] cytoplasm [GO:0005737]; protein-containing complex [GO:0032991]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; identical protein binding [GO:0042802]; acetoacetic acid catabolic process [GO:0043442]; fatty acid beta-oxidation [GO:0006635] acetyl-CoA C-acetyltransferase activity [GO:0003985]; identical protein binding [GO:0042802] GO:0003985; GO:0005737; GO:0006635; GO:0032991; GO:0042802; GO:0043442 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P17445 BETB_ECOLI Betaine aldehyde dehydrogenase (BADH) (EC 1.2.1.8) betB b0312 JW0304 betB 52,911 glycine betaine biosynthetic process from choline [GO:0019285]; response to osmotic stress [GO:0006970]; response to X-ray [GO:0010165] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; betaine-aldehyde dehydrogenase activity [GO:0008802]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; glycine betaine biosynthetic process from choline [GO:0019285]; response to osmotic stress [GO:0006970]; response to X-ray [GO:0010165] aldehyde dehydrogenase (NAD+) activity [GO:0004029]; betaine-aldehyde dehydrogenase activity [GO:0008802]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] GO:0004029; GO:0005829; GO:0006970; GO:0008802; GO:0010165; GO:0019285; GO:0032991; GO:0042802; GO:0046872 +P0AB33 BSSS_ECOLI Biofilm regulator BssS bssS yceP b1060 JW5152 yceP bssS 9,664 regulation of single-species biofilm formation [GO:1900190]; single-species submerged biofilm formation [GO:0090609] regulation of single-species biofilm formation [GO:1900190]; single-species submerged biofilm formation [GO:0090609] GO:0090609; GO:1900190 +P42628 DLST_ECOLI Probable serine transporter dlsT yhaO b3110 JW5519 yhaO dlsT 48,315 amino acid transport [GO:0006865]; cysteine catabolic process [GO:0009093]; response to L-cysteine [GO:1901367] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; amino acid transport [GO:0006865]; cysteine catabolic process [GO:0009093]; response to L-cysteine [GO:1901367] GO:0005886; GO:0006865; GO:0009093; GO:0016021; GO:1901367 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein. +P0A6Y8 DNAK_ECOLI Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK groP grpF seg b0014 JW0013 groP grpF seg dnaK 69,115 cellular response to unfolded protein [GO:0034620]; chaperone cofactor-dependent protein refolding [GO:0051085]; DNA replication [GO:0006260]; protein-containing complex assembly [GO:0065003]; protein-containing complex disassembly [GO:0032984]; response to heat [GO:0009408] cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; chaperone binding [GO:0051087]; protein folding chaperone [GO:0044183]; sigma factor antagonist activity [GO:0016989]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]; cellular response to unfolded protein [GO:0034620]; chaperone cofactor-dependent protein refolding [GO:0051085]; DNA replication [GO:0006260]; protein-containing complex assembly [GO:0065003]; protein-containing complex disassembly [GO:0032984]; response to heat [GO:0009408] ADP binding [GO:0043531]; ATPase activity [GO:0016887]; ATP binding [GO:0005524]; chaperone binding [GO:0051087]; protein folding chaperone [GO:0044183]; sigma factor antagonist activity [GO:0016989]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270] GO:0005524; GO:0005737; GO:0005829; GO:0005886; GO:0006260; GO:0008270; GO:0009408; GO:0016020; GO:0016234; GO:0016887; GO:0016989; GO:0032984; GO:0032991; GO:0034620; GO:0043531; GO:0044183; GO:0051082; GO:0051085; GO:0051087; GO:0065003 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16079137}. Cell inner membrane {ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000269|PubMed:16079137}. +P00370 DHE4_ECOLI NADP-specific glutamate dehydrogenase (NADP-GDH) (EC 1.4.1.4) gdhA b1761 JW1750 gdhA 48,581 glutamate biosynthetic process [GO:0006537] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamate dehydrogenase (NADP+) activity [GO:0004354]; identical protein binding [GO:0042802]; glutamate biosynthetic process [GO:0006537] glutamate dehydrogenase (NADP+) activity [GO:0004354]; identical protein binding [GO:0042802] GO:0004354; GO:0005737; GO:0005829; GO:0006537; GO:0042802 +P0ABT2 DPS_ECOLI DNA protection during starvation protein (EC 1.16.-.-) dps pexB vtm b0812 JW0797 pexB vtm dps 18,695 cellular iron ion homeostasis [GO:0006879]; chromosome condensation [GO:0030261]; response to starvation [GO:0042594] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoid [GO:0009295] cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoid [GO:0009295]; DNA binding [GO:0003677]; ferric iron binding [GO:0008199]; identical protein binding [GO:0042802]; oxidoreductase activity, acting on metal ions [GO:0016722]; cellular iron ion homeostasis [GO:0006879]; chromosome condensation [GO:0030261]; response to starvation [GO:0042594] DNA binding [GO:0003677]; ferric iron binding [GO:0008199]; identical protein binding [GO:0042802]; oxidoreductase activity, acting on metal ions [GO:0016722] GO:0003677; GO:0005737; GO:0006879; GO:0008199; GO:0009295; GO:0016020; GO:0016722; GO:0030261; GO:0042594; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm, nucleoid. +P46481 AAEB_ECOLI p-hydroxybenzoic acid efflux pump subunit AaeB (pHBA efflux pump protein B) aaeB yhcP b3240 JW3209 yhcP aaeB 73,591 carboxylic acid transport [GO:0046942]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; carboxylic acid transport [GO:0046942]; transmembrane transport [GO:0055085] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857; GO:0046942; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AC28 5FCL_ECOLI 5-formyltetrahydrofolate cyclo-ligase (5-FCL) (EC 6.3.3.2) (5,10-methenyltetrahydrofolate synthetase) (MTHFS) ygfA b2912 JW2879 ygfA 21,105 dormancy process [GO:0022611]; folic acid-containing compound biosynthetic process [GO:0009396]; tetrahydrofolate interconversion [GO:0035999] 5-formyltetrahydrofolate cyclo-ligase activity [GO:0030272]; ATP binding [GO:0005524]; dormancy process [GO:0022611]; folic acid-containing compound biosynthetic process [GO:0009396]; tetrahydrofolate interconversion [GO:0035999] 5-formyltetrahydrofolate cyclo-ligase activity [GO:0030272]; ATP binding [GO:0005524] GO:0005524; GO:0009396; GO:0022611; GO:0030272; GO:0035999 +P42912 AGAI_ECOLI Putative deaminase AgaI (EC 3.5.99.-) agaI yraG b3141 JW3110 yraG agaI 27,724 carbohydrate metabolic process [GO:0005975]; glucosamine catabolic process [GO:0006043]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; galactosamine-6-phosphate isomerase activity [GO:0043877]; glucosamine-6-phosphate deaminase activity [GO:0004342]; identical protein binding [GO:0042802]; carbohydrate metabolic process [GO:0005975]; glucosamine catabolic process [GO:0006043]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] galactosamine-6-phosphate isomerase activity [GO:0043877]; glucosamine-6-phosphate deaminase activity [GO:0004342]; identical protein binding [GO:0042802] GO:0004342; GO:0005737; GO:0005829; GO:0005975; GO:0006043; GO:0006046; GO:0006048; GO:0019262; GO:0042802; GO:0043877 +P0AGE6 CHRR_ECOLI Quinone reductase (EC 1.6.5.2) (Chromate reductase) (CHRR) (EC 1.6.-.-) (NAD(P)H dehydrogenase (quinone)) chrR yieF b3713 JW3691 yieF chrR 20,376 xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829] cytosol [GO:0005829]; FMN binding [GO:0010181]; NADH dehydrogenase (quinone) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753]; oxidoreductase activity [GO:0016491]; xenobiotic metabolic process [GO:0006805] FMN binding [GO:0010181]; NADH dehydrogenase (quinone) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753]; oxidoreductase activity [GO:0016491] GO:0005829; GO:0006805; GO:0008753; GO:0010181; GO:0016491; GO:0050136 +P76291 CMOB_ECOLI tRNA U34 carboxymethyltransferase (EC 2.5.1.-) cmoB yecP b1871 JW1860 yecP cmoB 37,007 tRNA wobble uridine modification [GO:0002098] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765]; tRNA wobble uridine modification [GO:0002098] identical protein binding [GO:0042802]; transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765] GO:0002098; GO:0016765; GO:0032991; GO:0042802 +P08622 DNAJ_ECOLI Chaperone protein DnaJ (HSP40) (Heat shock protein J) dnaJ groP b0015 JW0014 groP dnaJ 41,100 chaperone cofactor-dependent protein refolding [GO:0051085]; DNA replication [GO:0006260]; protein-containing complex assembly [GO:0065003]; protein folding [GO:0006457]; protein refolding [GO:0042026]; response to heat [GO:0009408]; viral process [GO:0016032] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; protein-containing complex [GO:0032991] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; chaperone binding [GO:0051087]; heat shock protein binding [GO:0031072]; protein disulfide isomerase activity [GO:0003756]; protein disulfide oxidoreductase activity [GO:0015035]; sigma factor antagonist activity [GO:0016989]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]; chaperone cofactor-dependent protein refolding [GO:0051085]; DNA replication [GO:0006260]; protein folding [GO:0006457]; protein refolding [GO:0042026]; protein-containing complex assembly [GO:0065003]; response to heat [GO:0009408]; viral process [GO:0016032] ATP binding [GO:0005524]; chaperone binding [GO:0051087]; heat shock protein binding [GO:0031072]; protein disulfide isomerase activity [GO:0003756]; protein disulfide oxidoreductase activity [GO:0015035]; sigma factor antagonist activity [GO:0016989]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270] GO:0003756; GO:0005524; GO:0005737; GO:0005829; GO:0006260; GO:0006457; GO:0008270; GO:0009408; GO:0015035; GO:0016020; GO:0016032; GO:0016989; GO:0031072; GO:0032991; GO:0042026; GO:0051082; GO:0051085; GO:0051087; GO:0065003 SUBCELLULAR LOCATION: Cytoplasm. +P03007 DPO3E_ECOLI DNA polymerase III subunit epsilon (EC 2.7.7.7) dnaQ mutD b0215 JW0205 mutD dnaQ 27,099 DNA replication proofreading [GO:0045004] cytosol [GO:0005829]; DNA polymerase III, core complex [GO:0044776] cytosol [GO:0005829]; DNA polymerase III, core complex [GO:0044776]; 3'-5' exonuclease activity [GO:0008408]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; exonuclease activity [GO:0004527]; metal ion binding [GO:0046872]; DNA replication proofreading [GO:0045004] 3'-5' exonuclease activity [GO:0008408]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; exonuclease activity [GO:0004527]; metal ion binding [GO:0046872] GO:0003677; GO:0003887; GO:0004527; GO:0005829; GO:0008408; GO:0044776; GO:0045004; GO:0046872 +P00582 DPO1_ECOLI DNA polymerase I (POL I) (EC 2.7.7.7) polA resA b3863 JW3835 resA polA 103,118 base-excision repair [GO:0006284]; DNA-dependent DNA replication [GO:0006261]; DNA repair [GO:0006281]; DNA replication [GO:0006260] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; 3'-5' exonuclease activity [GO:0008408]; 5'-3' exonuclease activity [GO:0008409]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; base-excision repair [GO:0006284]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA-dependent DNA replication [GO:0006261] 3'-5' exonuclease activity [GO:0008408]; 5'-3' exonuclease activity [GO:0008409]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887] GO:0003677; GO:0003887; GO:0005737; GO:0005829; GO:0006260; GO:0006261; GO:0006281; GO:0006284; GO:0008408; GO:0008409 +P0AEJ0 EMRB_ECOLI Multidrug export protein EmrB emrB b2686 JW2661 emrB 55,624 proton transmembrane transport [GO:1902600]; response to antibiotic [GO:0046677]; response to toxic substance [GO:0009636]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; proton transmembrane transport [GO:1902600]; response to antibiotic [GO:0046677]; response to toxic substance [GO:0009636]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0009636; GO:0022857; GO:0046677; GO:0055085; GO:1902600; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P31442 EMRD_ECOLI Multidrug resistance protein D emrD yicQ b3673 JW5634 yicQ emrD 42,216 xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; xenobiotic transmembrane transporter activity [GO:0042910]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0005887; GO:0016021; GO:0042910; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76556 EUTP_ECOLI Probable acetate kinase EutP (EC 2.7.2.1) (Ethanolamine utilization protein EutP) eutP ypfD b2461 JW2445 ypfD eutP 17,659 ethanolamine catabolic process [GO:0046336] ATP binding [GO:0005524]; ethanolamine catabolic process [GO:0046336] ATP binding [GO:0005524] GO:0005524; GO:0046336 SUBCELLULAR LOCATION: Bacterial microcompartment {ECO:0000250|UniProtKB:P0A208}. +Q47146 FADE_ECOLI Acyl-coenzyme A dehydrogenase (ACDH) (Acyl-CoA dehydrogenase) (EC 1.3.8.7) (EC 1.3.8.8) fadE yafH b0221 JW5020 yafH fadE 89,224 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; long-chain-acyl-CoA dehydrogenase activity [GO:0004466]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; long-chain-acyl-CoA dehydrogenase activity [GO:0004466] GO:0003995; GO:0004466; GO:0005886; GO:0033539; GO:0050660 +P36547 EUTR_ECOLI HTH-type DNA-binding transcriptional activator EutR (Ethanolamine operon regulatory protein) eutR yfeG b2437 JW2430 yfeG eutR 40,160 DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0043565 +P67662 AAER_ECOLI HTH-type transcriptional activator AaeR aaeR yhcS b3243 JW3212 yhcS aaeR 34,516 DNA-templated transcription, initiation [GO:0006352]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; DNA-templated transcription, initiation [GO:0006352]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006351; GO:0006352; GO:0006355; GO:0045893 +P00350 6PGD_ECOLI 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) gnd b2029 JW2011 gnd 51,481 D-gluconate catabolic process [GO:0046177]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051] cytosol [GO:0005829] cytosol [GO:0005829]; identical protein binding [GO:0042802]; NADP binding [GO:0050661]; phosphogluconate dehydrogenase (decarboxylating) activity [GO:0004616]; protein homodimerization activity [GO:0042803]; D-gluconate catabolic process [GO:0046177]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051] identical protein binding [GO:0042802]; NADP binding [GO:0050661]; phosphogluconate dehydrogenase (decarboxylating) activity [GO:0004616]; protein homodimerization activity [GO:0042803] GO:0004616; GO:0005829; GO:0006098; GO:0009051; GO:0042802; GO:0042803; GO:0046177; GO:0050661 +P0ACN4 ALLR_ECOLI HTH-type transcriptional repressor AllR (Negative regulator of allantoin and glyoxylate utilization operons) allR glxA3 ybbU b0506 JW0494 glxA3 ybbU allR 29,270 cellular response to DNA damage stimulus [GO:0006974]; negative regulation of transcription, DNA-templated [GO:0045892] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; cellular response to DNA damage stimulus [GO:0006974]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802] GO:0003677; GO:0003700; GO:0005829; GO:0006974; GO:0042802; GO:0045892 +P75820 AMID_ECOLI N-acetylmuramoyl-L-alanine amidase AmiD (EC 3.5.1.28) amiD ybjR b0867 JW0851 ybjR amiD 31,072 cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253]; peptidoglycan turnover [GO:0009254] cell outer membrane [GO:0009279]; outer membrane [GO:0019867] cell outer membrane [GO:0009279]; outer membrane [GO:0019867]; N-acetyl-anhydromuramoyl-L-alanine amidase activity [GO:0009392]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; zinc ion binding [GO:0008270]; cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253]; peptidoglycan turnover [GO:0009254] N-acetyl-anhydromuramoyl-L-alanine amidase activity [GO:0009392]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; zinc ion binding [GO:0008270] GO:0008270; GO:0008745; GO:0009253; GO:0009254; GO:0009279; GO:0009392; GO:0019867; GO:0071555 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P24177 ACRD_ECOLI Probable aminoglycoside efflux pump (Acriflavine resistance protein D) acrD yffA b2470 JW2454 yffA acrD 113,047 bile acid and bile salt transport [GO:0015721]; response to antibiotic [GO:0046677]; response to toxic substance [GO:0009636]; xenobiotic transport [GO:0042908] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; bile acid transmembrane transporter activity [GO:0015125]; efflux transmembrane transporter activity [GO:0015562]; xenobiotic transmembrane transporter activity [GO:0042910]; bile acid and bile salt transport [GO:0015721]; response to antibiotic [GO:0046677]; response to toxic substance [GO:0009636]; xenobiotic transport [GO:0042908] bile acid transmembrane transporter activity [GO:0015125]; efflux transmembrane transporter activity [GO:0015562]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0005887; GO:0009636; GO:0015125; GO:0015562; GO:0015721; GO:0016020; GO:0042908; GO:0042910; GO:0046677 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P24244 APPX_ECOLI Putative cytochrome bd-II ubiquinol oxidase subunit AppX appX yccB b4592 JW0961.1 b0979.1 yccB appX 3,597 cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0009279; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=In sucrose cushions fractionates with the outer membrane, in sarcosyl fractionation with the inner membrane. May have its C-terminus in the cytoplasm (PubMed:21778229). {ECO:0000269|PubMed:21778229}. +P30843 BASR_ECOLI Transcriptional regulatory protein BasR basR pmrA b4113 JW4074 pmrA basR 25,031 phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355]; response to antibiotic [GO:0046677]; response to iron(III) ion [GO:0010041] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355]; response to antibiotic [GO:0046677]; response to iron(III) ion [GO:0010041] DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000160; GO:0000976; GO:0001216; GO:0005829; GO:0006355; GO:0010041; GO:0032993; GO:0046677 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P00722 BGAL_ECOLI Beta-galactosidase (Beta-gal) (EC 3.2.1.23) (Lactase) lacZ b0344 JW0335 lacZ 116,483 lactose catabolic process [GO:0005990] beta-galactosidase complex [GO:0009341] beta-galactosidase complex [GO:0009341]; alkali metal ion binding [GO:0031420]; beta-galactosidase activity [GO:0004565]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; lactose catabolic process [GO:0005990] alkali metal ion binding [GO:0031420]; beta-galactosidase activity [GO:0004565]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287] GO:0000287; GO:0004565; GO:0005990; GO:0009341; GO:0030246; GO:0031420; GO:0042802 +P56976 BLR_ECOLI Divisome-associated membrane protein Blr (Beta-lactam resistance protein) blr b4409 JW5963 blr 4,556 cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to cell envelope stress [GO:0036460]; response to antibiotic [GO:0046677] division septum [GO:0000935]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] division septum [GO:0000935]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to cell envelope stress [GO:0036460]; response to antibiotic [GO:0046677] GO:0000935; GO:0005886; GO:0007049; GO:0016021; GO:0036460; GO:0046677; GO:0051301 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:10931331, ECO:0000269|PubMed:22885295}; Single-pass membrane protein {ECO:0000269|PubMed:10931331, ECO:0000269|PubMed:22885295}. Note=Localizes to the division septum. Localization requires FtsQ and FtsN. +P69228 BAER_ECOLI Transcriptional regulatory protein BaeR baeR b2079 JW2064 baeR 27,656 positive regulation of DNA-templated transcription, initiation [GO:2000144]; regulation of response to drug [GO:2001023]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216]; identical protein binding [GO:0042802]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; regulation of response to drug [GO:2001023]; transcription, DNA-templated [GO:0006351] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216]; identical protein binding [GO:0042802]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000976; GO:0000986; GO:0001216; GO:0005829; GO:0006351; GO:0032993; GO:0042802; GO:2000144; GO:2001023 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0ABD8 BCCP_ECOLI Biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP) accB fabE b3255 JW3223 fabE accB 16,687 fatty acid biosynthetic process [GO:0006633]; protein biotinylation [GO:0009305] acetyl-CoA carboxylase complex [GO:0009317]; cytoplasm [GO:0005737]; cytosol [GO:0005829] acetyl-CoA carboxylase complex [GO:0009317]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; acetyl-CoA carboxylase activity [GO:0003989]; fatty acid biosynthetic process [GO:0006633]; protein biotinylation [GO:0009305] acetyl-CoA carboxylase activity [GO:0003989] GO:0003989; GO:0005737; GO:0005829; GO:0006633; GO:0009305; GO:0009317 +P64524 CBTA_ECOLI Cytoskeleton-binding toxin CbtA (Toxin CbtA) (Toxin YeeV) cbtA yeeV b2005 JW1987 yeeV cbtA 13,899 autolysis [GO:0001896]; negative regulation of cytoskeleton organization [GO:0051494]; negative regulation of FtsZ-dependent cytokinesis [GO:2000245]; regulation of cell shape [GO:0008360] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; cytoskeletal protein binding [GO:0008092]; autolysis [GO:0001896]; negative regulation of cytoskeleton organization [GO:0051494]; negative regulation of FtsZ-dependent cytokinesis [GO:2000245]; regulation of cell shape [GO:0008360] cytoskeletal protein binding [GO:0008092] GO:0001896; GO:0005737; GO:0008092; GO:0008360; GO:0051494; GO:2000245 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28931012}. +P56100 CYDX_ECOLI Cytochrome bd-I ubiquinol oxidase subunit X (EC 7.1.1.7) (Cytochrome bd-I oxidase subunit X) (Cytochrome d ubiquinol oxidase subunit X) cydX ybgT b4515 JW0724 ybgT cydX 4,042 oxidative phosphorylation [GO:0006119] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; outer membrane [GO:0019867]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; outer membrane [GO:0019867]; plasma membrane [GO:0005886]; oxidoreductase activity, acting on diphenols and related substances as donors [GO:0016679]; oxidative phosphorylation [GO:0006119] oxidoreductase activity, acting on diphenols and related substances as donors [GO:0016679] GO:0005886; GO:0005887; GO:0006119; GO:0016020; GO:0016679; GO:0019867 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=In sucrose cushions fractionates with both the inner and outer membranes. {ECO:0000269|PubMed:19121005, ECO:0000269|PubMed:21778229}. +P23886 CYDC_ECOLI ATP-binding/permease protein CydC cydC mdrA mdrH surB b0886 JW0869 mdrA mdrH surB cydC 62,920 cell redox homeostasis [GO:0045454]; cysteine export across plasma membrane [GO:0033228]; glutathione transmembrane transport [GO:0034775]; regulation of heme biosynthetic process [GO:0070453] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cell redox homeostasis [GO:0045454]; cysteine export across plasma membrane [GO:0033228]; glutathione transmembrane transport [GO:0034775]; regulation of heme biosynthetic process [GO:0070453] ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005887; GO:0016021; GO:0016887; GO:0033228; GO:0034775; GO:0042626; GO:0043190; GO:0045454; GO:0070453 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:15919996}. +P38054 CUSA_ECOLI Cation efflux system protein CusA cusA ybdE b0575 JW0564 ybdE cusA 114,707 cellular copper ion homeostasis [GO:0006878]; copper ion export [GO:0060003]; detoxification of copper ion [GO:0010273]; plasma membrane copper ion transport [GO:0015679]; response to copper ion [GO:0046688]; response to silver ion [GO:0010272]; silver ion transport [GO:0015673] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; silver ion transmembrane transporter activity [GO:0015080]; xenobiotic transmembrane transporter activity [GO:0042910]; cellular copper ion homeostasis [GO:0006878]; copper ion export [GO:0060003]; detoxification of copper ion [GO:0010273]; plasma membrane copper ion transport [GO:0015679]; response to copper ion [GO:0046688]; response to silver ion [GO:0010272]; silver ion transport [GO:0015673] copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; silver ion transmembrane transporter activity [GO:0015080]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005375; GO:0005507; GO:0005886; GO:0006878; GO:0010272; GO:0010273; GO:0015080; GO:0015673; GO:0015679; GO:0016021; GO:0042910; GO:0046688; GO:0060003 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P37349 DHAM_ECOLI PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM (EC 2.7.1.121) (Dihydroxyacetone kinase subunit M) dhaM ycgC b1198 JW5185 ycgC dhaM 51,449 cellular response to DNA damage stimulus [GO:0006974]; glycerol catabolic process [GO:0019563]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytosol [GO:0005829]; integral component of membrane [GO:0016021] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; phosphoenolpyruvate-glycerone phosphotransferase activity [GO:0047324]; cellular response to DNA damage stimulus [GO:0006974]; glycerol catabolic process [GO:0019563]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] phosphoenolpyruvate-glycerone phosphotransferase activity [GO:0047324] GO:0005829; GO:0006974; GO:0009401; GO:0016021; GO:0019563; GO:0047324 +P0A6P5 DER_ECOLI GTPase Der (Double era-like domain protein) (GTP-binding protein EngA) der engA yfgK b2511 JW5403 engA yfgK der 55,036 ribosomal large subunit assembly [GO:0000027] cytosol [GO:0005829] cytosol [GO:0005829]; GTP binding [GO:0005525]; GTPase activating protein binding [GO:0032794]; GTPase activity [GO:0003924]; guanosine tetraphosphate binding [GO:0097216]; ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022]; ribosomal large subunit assembly [GO:0000027] GTPase activating protein binding [GO:0032794]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; guanosine tetraphosphate binding [GO:0097216]; ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022] GO:0000027; GO:0003924; GO:0005525; GO:0005829; GO:0032794; GO:0043022; GO:0043023; GO:0097216 +P76245 DGCP_ECOLI Diguanylate cyclase DgcP (DGC) (EC 2.7.7.65) dgcP yeaP b1794 JW5292 yeaP dgcP 38,546 diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872] diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872] GO:0005525; GO:0046872; GO:0052621 +P08555 DSDX_ECOLI D-serine transporter DsdX dsdX orf445 yfdA yfdD b2365 JW2362 orf445 yfdA yfdD dsdX 47,163 cellular response to DNA damage stimulus [GO:0006974]; D-serine transport [GO:0042942]; gluconate transmembrane transport [GO:0035429] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; D-serine transmembrane transporter activity [GO:0042945]; gluconate transmembrane transporter activity [GO:0015128]; cellular response to DNA damage stimulus [GO:0006974]; D-serine transport [GO:0042942]; gluconate transmembrane transport [GO:0035429] D-serine transmembrane transporter activity [GO:0042945]; gluconate transmembrane transporter activity [GO:0015128] GO:0005886; GO:0005887; GO:0006974; GO:0015128; GO:0035429; GO:0042942; GO:0042945 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305}. +P39276 DTPC_ECOLI Dipeptide and tripeptide permease C (Dipeptide/tripeptide:H(+) symporter DtpC) dtpC yjdL b4130 JW4091 yjdL dtpC 53,055 dipeptide transmembrane transport [GO:0035442]; protein transport [GO:0015031]; proton transmembrane transport [GO:1902600]; tripeptide transmembrane transport [GO:0035443] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; proton transmembrane transporter activity [GO:0015078]; tripeptide transmembrane transporter activity [GO:0042937]; dipeptide transmembrane transport [GO:0035442]; protein transport [GO:0015031]; proton transmembrane transport [GO:1902600]; tripeptide transmembrane transport [GO:0035443] dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; proton transmembrane transporter activity [GO:0015078]; tripeptide transmembrane transporter activity [GO:0042937] GO:0005886; GO:0005887; GO:0015031; GO:0015078; GO:0015333; GO:0035442; GO:0035443; GO:0042937; GO:0071916; GO:1902600 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P0ACC3 ERPA_ECOLI Iron-sulfur cluster insertion protein ErpA erpA yadR b0156 JW0152 yadR erpA 12,100 aerobic respiration [GO:0009060]; anaerobic respiration [GO:0009061]; iron-sulfur cluster assembly [GO:0016226]; protein maturation [GO:0051604]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035] cytosol [GO:0005829] cytosol [GO:0005829]; 2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; aerobic respiration [GO:0009060]; anaerobic respiration [GO:0009061]; iron-sulfur cluster assembly [GO:0016226]; protein maturation [GO:0051604]; protein maturation by [4Fe-4S] cluster transfer [GO:0106035] 2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506] GO:0005506; GO:0005829; GO:0009060; GO:0009061; GO:0016226; GO:0051537; GO:0051539; GO:0051604; GO:0106035 +P76491 5DNU_ECOLI 5'-deoxynucleotidase YfbR (EC 3.1.3.89) (5'-deoxyribonucleotidase) (Nucleoside 5'-monophosphate phosphohydrolase) yfbR b2291 JW2288 yfbR 22,708 dUMP biosynthetic process [GO:0006226]; pyrimidine deoxyribonucleotide salvage [GO:0010139] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 5'-deoxynucleotidase activity [GO:0002953]; cobalt ion binding [GO:0050897]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; dUMP biosynthetic process [GO:0006226]; pyrimidine deoxyribonucleotide salvage [GO:0010139] 5'-deoxynucleotidase activity [GO:0002953]; cobalt ion binding [GO:0050897]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166] GO:0000166; GO:0002953; GO:0005737; GO:0006226; GO:0010139; GO:0042802; GO:0050897 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01100}. +P0A991 ALF1_ECOLI Fructose-bisphosphate aldolase class 1 (EC 4.1.2.13) (Fructose-bisphosphate aldolase class I) (FBP aldolase) fbaB dhnA b2097 JW5344 dhnA fbaB 38,109 glycolytic process [GO:0006096] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; fructose-bisphosphate aldolase activity [GO:0004332]; identical protein binding [GO:0042802]; glycolytic process [GO:0006096] fructose-bisphosphate aldolase activity [GO:0004332]; identical protein binding [GO:0042802] GO:0004332; GO:0005829; GO:0006096; GO:0016020; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P39451 ADHP_ECOLI Alcohol dehydrogenase, propanol-preferring (EC 1.1.1.1) adhP yddN b1478 JW1474 yddN adhP 35,380 acetaldehyde catabolic process [GO:0046187]; cellular response to DNA damage stimulus [GO:0006974]; response to ethanol [GO:0045471] alcohol dehydrogenase (NAD+) activity [GO:0004022]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; zinc ion binding [GO:0008270]; acetaldehyde catabolic process [GO:0046187]; cellular response to DNA damage stimulus [GO:0006974]; response to ethanol [GO:0045471] alcohol dehydrogenase (NAD+) activity [GO:0004022]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; zinc ion binding [GO:0008270] GO:0004022; GO:0006974; GO:0008270; GO:0016616; GO:0045471; GO:0046187 +P46883 AMO_ECOLI Primary amine oxidase (EC 1.4.3.21) (2-phenylethylamine oxidase) (Copper amine oxidase) (Tyramine oxidase) tynA maoA b1386 JW1381 maoA tynA 84,379 amine metabolic process [GO:0009308]; L-phenylalanine catabolic process [GO:0006559]; phenylethylamine catabolic process [GO:0019607] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; aliphatic-amine oxidase activity [GO:0052595]; aminoacetone:oxygen oxidoreductase(deaminating) activity [GO:0052594]; calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; phenethylamine:oxygen oxidoreductase (deaminating) activity [GO:0052596]; primary amine oxidase activity [GO:0008131]; quinone binding [GO:0048038]; tryptamine:oxygen oxidoreductase (deaminating) activity [GO:0052593]; amine metabolic process [GO:0009308]; L-phenylalanine catabolic process [GO:0006559]; phenylethylamine catabolic process [GO:0019607] aliphatic-amine oxidase activity [GO:0052595]; aminoacetone:oxygen oxidoreductase(deaminating) activity [GO:0052594]; calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; phenethylamine:oxygen oxidoreductase (deaminating) activity [GO:0052596]; primary amine oxidase activity [GO:0008131]; quinone binding [GO:0048038]; tryptamine:oxygen oxidoreductase (deaminating) activity [GO:0052593] GO:0005507; GO:0005509; GO:0006559; GO:0008131; GO:0009308; GO:0019607; GO:0042597; GO:0048038; GO:0052593; GO:0052594; GO:0052595; GO:0052596 SUBCELLULAR LOCATION: Periplasm. +P0ACS9 ACRR_ECOLI HTH-type transcriptional regulator AcrR (Potential acrAB operon repressor) acrR ybaH b0464 JW0453 ybaH acrR 24,767 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; response to drug [GO:0042493]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; drug binding [GO:0008144]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; response to drug [GO:0042493]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; drug binding [GO:0008144]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006351; GO:0006355; GO:0008144; GO:0042493; GO:0043565; GO:0045892 +P0A6C8 ARGB_ECOLI Acetylglutamate kinase (EC 2.7.2.8) (N-acetyl-L-glutamate 5-phosphotransferase) (NAG kinase) (NAGK) argB b3959 JW5553 argB 27,160 arginine biosynthetic process [GO:0006526]; arginine biosynthetic process via ornithine [GO:0042450]; cellular response to DNA damage stimulus [GO:0006974] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; acetylglutamate kinase activity [GO:0003991]; arginine binding [GO:0034618]; ATP binding [GO:0005524]; arginine biosynthetic process [GO:0006526]; arginine biosynthetic process via ornithine [GO:0042450]; cellular response to DNA damage stimulus [GO:0006974] acetylglutamate kinase activity [GO:0003991]; arginine binding [GO:0034618]; ATP binding [GO:0005524] GO:0003991; GO:0005524; GO:0005737; GO:0006526; GO:0006974; GO:0034618; GO:0042450 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00082}. +P08204 ARAB_ECOLI Ribulokinase (EC 2.7.1.16) araB b0063 JW0062 araB 61,089 arabinose catabolic process [GO:0019568]; carbohydrate catabolic process [GO:0016052]; L-arabinose catabolic process [GO:0019572]; L-arabinose catabolic process to xylulose 5-phosphate [GO:0019569] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; D-ribulokinase activity [GO:0019150]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; ribulokinase activity [GO:0008741]; arabinose catabolic process [GO:0019568]; carbohydrate catabolic process [GO:0016052]; L-arabinose catabolic process [GO:0019572]; L-arabinose catabolic process to xylulose 5-phosphate [GO:0019569] ATP binding [GO:0005524]; D-ribulokinase activity [GO:0019150]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; ribulokinase activity [GO:0008741] GO:0005524; GO:0005737; GO:0008741; GO:0016052; GO:0016773; GO:0019150; GO:0019568; GO:0019569; GO:0019572 +P13001 BIOH_ECOLI Pimeloyl-[acyl-carrier protein] methyl ester esterase (EC 3.1.1.85) (Biotin synthesis protein BioH) (Carboxylesterase BioH) bioH bioB b3412 JW3375 bioB bioH 28,505 biotin biosynthetic process [GO:0009102] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; carboxylic ester hydrolase activity [GO:0052689]; pimelyl-[acyl-carrier protein] methyl ester esterase activity [GO:0090499]; biotin biosynthetic process [GO:0009102] carboxylic ester hydrolase activity [GO:0052689]; pimelyl-[acyl-carrier protein] methyl ester esterase activity [GO:0090499] GO:0005737; GO:0009102; GO:0052689; GO:0090499 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P75990 BLUF_ECOLI Blue light- and temperature-regulated antirepressor BluF (Blrp) bluF blrp ycgF b1163 JW1150 blrp ycgF bluF 45,295 negative regulation of DNA-binding transcription factor activity [GO:0043433]; protein-chromophore linkage [GO:0018298]; response to blue light [GO:0009637] activating transcription factor binding [GO:0033613]; blue light photoreceptor activity [GO:0009882]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; repressing transcription factor binding [GO:0070491]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; protein-chromophore linkage [GO:0018298]; response to blue light [GO:0009637] activating transcription factor binding [GO:0033613]; blue light photoreceptor activity [GO:0009882]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; repressing transcription factor binding [GO:0070491] GO:0009637; GO:0009882; GO:0018298; GO:0033613; GO:0043433; GO:0050660; GO:0070491; GO:0071949 +P39297 BSMA_ECOLI Lipoprotein BsmA (Biofilm stress and motility protein) bsmA yjfO b4189 JW5743 yjfO bsmA 12,038 cellular response to DNA damage stimulus [GO:0006974]; response to hydrogen peroxide [GO:0042542]; single-species biofilm formation [GO:0044010] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; cellular response to DNA damage stimulus [GO:0006974]; response to hydrogen peroxide [GO:0042542]; single-species biofilm formation [GO:0044010] GO:0005886; GO:0006974; GO:0042542; GO:0044010 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P17444 BETA_ECOLI Oxygen-dependent choline dehydrogenase (CDH) (CHD) (EC 1.1.99.1) (Betaine aldehyde dehydrogenase) (BADH) (EC 1.2.1.8) betA b0311 JW0303 betA 61,878 glycine betaine biosynthetic process from choline [GO:0019285]; response to osmotic stress [GO:0006970] membrane [GO:0016020]; plasma membrane [GO:0005886] membrane [GO:0016020]; plasma membrane [GO:0005886]; betaine-aldehyde dehydrogenase activity [GO:0008802]; choline dehydrogenase activity [GO:0008812]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity [GO:0016491]; glycine betaine biosynthetic process from choline [GO:0019285]; response to osmotic stress [GO:0006970] betaine-aldehyde dehydrogenase activity [GO:0008802]; choline dehydrogenase activity [GO:0008812]; flavin adenine dinucleotide binding [GO:0050660]; oxidoreductase activity [GO:0016491] GO:0005886; GO:0006970; GO:0008802; GO:0008812; GO:0016020; GO:0016491; GO:0019285; GO:0050660 SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:3512525}; Peripheral membrane protein {ECO:0000269|PubMed:3512525}. +Q46898 CAS5_ECOLI CRISPR system Cascade subunit CasD casD cas5 ygcI b2757 JW5844 cas5 ygcI casD 25,209 defense response to virus [GO:0051607]; maintenance of CRISPR repeat elements [GO:0043571] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; DNA/RNA hybrid binding [GO:0071667]; RNA binding [GO:0003723]; defense response to virus [GO:0051607]; maintenance of CRISPR repeat elements [GO:0043571] DNA/RNA hybrid binding [GO:0071667]; RNA binding [GO:0003723] GO:0003723; GO:0032991; GO:0043571; GO:0051607; GO:0071667 +P31551 CAID_ECOLI Carnitinyl-CoA dehydratase (EC 4.2.1.149) (Crotonobetainyl-CoA hydratase) caiD yaaL b0036 JW0035 yaaL caiD 28,190 carnitine catabolic process [GO:0042413] carnitine racemase activity [GO:0008809]; hydro-lyase activity [GO:0016836]; carnitine catabolic process [GO:0042413] carnitine racemase activity [GO:0008809]; hydro-lyase activity [GO:0016836] GO:0008809; GO:0016836; GO:0042413 +P17410 CHBR_ECOLI HTH-type transcriptional regulator ChbR (Chb operon repressor) chbR celD b1735 JW1724 celD chbR 32,968 negative regulation of transcription, DNA-templated [GO:0045892] core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892] core promoter sequence-specific DNA binding [GO:0001046]; DNA-binding transcription factor activity [GO:0003700] GO:0001046; GO:0003700; GO:0045892 +P0AE63 CHAB_ECOLI Putative cation transport regulator ChaB chaB b1217 JW1208 chaB 8,945 +P0A982 CSPH_ECOLI Cold shock-like protein CspH (CSP-H) cspH cspK b0989 JW5134 cspK cspH 7,720 negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; transcription antitermination factor activity, RNA binding [GO:0001072]; negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468] DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; transcription antitermination factor activity, RNA binding [GO:0001072] GO:0001072; GO:0003676; GO:0003677; GO:0003723; GO:0005829; GO:0010468; GO:0060567 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P17846 CYSI_ECOLI Sulfite reductase [NADPH] hemoprotein beta-component (SiR-HP) (SiRHP) (EC 1.8.1.2) cysI b2763 JW2733 cysI 63,998 cysteine biosynthetic process [GO:0019344]; hydrogen sulfide biosynthetic process [GO:0070814]; sulfate assimilation [GO:0000103] sulfite reductase complex (NADPH) [GO:0009337] sulfite reductase complex (NADPH) [GO:0009337]; 4 iron, 4 sulfur cluster binding [GO:0051539]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; sulfite reductase (ferredoxin) activity [GO:0050311]; sulfite reductase (NADPH) activity [GO:0004783]; sulfite reductase activity [GO:0016002]; cysteine biosynthetic process [GO:0019344]; hydrogen sulfide biosynthetic process [GO:0070814]; sulfate assimilation [GO:0000103] 4 iron, 4 sulfur cluster binding [GO:0051539]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; NADP binding [GO:0050661]; sulfite reductase (ferredoxin) activity [GO:0050311]; sulfite reductase (NADPH) activity [GO:0004783]; sulfite reductase activity [GO:0016002] GO:0000103; GO:0004783; GO:0009337; GO:0016002; GO:0019344; GO:0020037; GO:0046872; GO:0050311; GO:0050661; GO:0051539; GO:0070814 +P0AAM1 CYBH_ECOLI Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit hyaC b0974 JW0956 hyaC 27,597 anaerobic respiration [GO:0009061]; fermentation [GO:0006113]; respiratory electron transport chain [GO:0022904] [Ni-Fe] hydrogenase complex [GO:0044569]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] [Ni-Fe] hydrogenase complex [GO:0044569]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; anaerobic respiration [GO:0009061]; fermentation [GO:0006113]; respiratory electron transport chain [GO:0022904] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; iron ion binding [GO:0005506] GO:0005506; GO:0005886; GO:0005887; GO:0006113; GO:0009055; GO:0009061; GO:0020037; GO:0022904; GO:0044569 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76316 DCYD_ECOLI D-cysteine desulfhydrase (EC 4.4.1.15) dcyD yedO b1919 JW5313 yedO dcyD 35,153 cellular response to sulfur starvation [GO:0010438]; D-amino acid metabolic process [GO:0046416]; D-cysteine catabolic process [GO:0019447]; sulfur compound metabolic process [GO:0006790]; sulfur utilization [GO:0006791] cytosol [GO:0005829] cytosol [GO:0005829]; 3-chloro-D-alanine dehydrochlorinase activity [GO:0019149]; D-cysteine desulfhydrase activity [GO:0019148]; pyridoxal phosphate binding [GO:0030170]; cellular response to sulfur starvation [GO:0010438]; D-amino acid metabolic process [GO:0046416]; D-cysteine catabolic process [GO:0019447]; sulfur compound metabolic process [GO:0006790]; sulfur utilization [GO:0006791] 3-chloro-D-alanine dehydrochlorinase activity [GO:0019149]; D-cysteine desulfhydrase activity [GO:0019148]; pyridoxal phosphate binding [GO:0030170] GO:0005829; GO:0006790; GO:0006791; GO:0010438; GO:0019148; GO:0019149; GO:0019447; GO:0030170; GO:0046416 +P0ABP6 DEDA_ECOLI Protein DedA (Protein DSG-1) dedA b2317 JW2314 dedA 24,510 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P64426 DIGH_ECOLI Glycosyl hydrolase DigH (EC 3.2.1.-) (Divisome-localized glycosyl hydrolase) digH yddW b1491 JW1486 yddW digH 49,574 cell wall organization [GO:0071555]; metabolic process [GO:0008152] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; cell wall organization [GO:0071555]; metabolic process [GO:0008152] hydrolase activity, acting on glycosyl bonds [GO:0016798] GO:0008152; GO:0009279; GO:0016798; GO:0071555 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:32152098}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. Note=Localizes to the divisome. {ECO:0000269|PubMed:32152098}. +P0ADB7 ECNB_ECOLI Entericidin B ecnB yjeU b4411 JW4108 yjeU ecnB 4,810 response to toxic substance [GO:0009636] membrane [GO:0016020]; plasma membrane [GO:0005886] membrane [GO:0016020]; plasma membrane [GO:0005886]; response to toxic substance [GO:0009636] GO:0005886; GO:0009636; GO:0016020 SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. +P0A6M2 DSBB_ECOLI Disulfide bond formation protein B (Disulfide oxidoreductase) dsbB roxB ycgA b1185 JW5182 roxB ycgA dsbB 20,142 protein folding [GO:0006457]; response to heat [GO:0009408] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; electron transfer activity [GO:0009055]; oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor [GO:0016672]; protein disulfide oxidoreductase activity [GO:0015035]; ubiquinone binding [GO:0048039]; protein folding [GO:0006457]; response to heat [GO:0009408] electron transfer activity [GO:0009055]; oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor [GO:0016672]; protein disulfide oxidoreductase activity [GO:0015035]; ubiquinone binding [GO:0048039] GO:0005887; GO:0006457; GO:0009055; GO:0009408; GO:0015035; GO:0016672; GO:0048039 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:7957076, ECO:0000269|PubMed:8430071}; Multi-pass membrane protein {ECO:0000269|PubMed:7957076, ECO:0000269|PubMed:8430071}. +P0A6C1 END4_ECOLI Endonuclease 4 (EC 3.1.21.2) (Endodeoxyribonuclease IV) (Endonuclease IV) nfo b2159 JW2146 nfo 31,480 base-excision repair [GO:0006284]; non-recombinational repair [GO:0000726] deoxyribonuclease IV (phage-T4-induced) activity [GO:0008833]; DNA binding [GO:0003677]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; endonuclease activity [GO:0004519]; phosphoric diester hydrolase activity [GO:0008081]; zinc ion binding [GO:0008270]; base-excision repair [GO:0006284]; non-recombinational repair [GO:0000726] deoxyribonuclease IV (phage-T4-induced) activity [GO:0008833]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; phosphoric diester hydrolase activity [GO:0008081]; zinc ion binding [GO:0008270] GO:0000726; GO:0003677; GO:0003906; GO:0004519; GO:0006284; GO:0008081; GO:0008270; GO:0008833 +P76052 ABGB_ECOLI p-aminobenzoyl-glutamate hydrolase subunit B (EC 3.5.1.-) (PABA-GLU hydrolase) (PGH) abgB ydaI b1337 JW1331 ECK1333 ydaI abgB 52,194 folic acid catabolic process [GO:0046657] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; dipeptidase activity [GO:0016805]; para-aminobenzoyl-glutamate hydrolase activity [GO:0071713]; protein heterodimerization activity [GO:0046982]; folic acid catabolic process [GO:0046657] dipeptidase activity [GO:0016805]; para-aminobenzoyl-glutamate hydrolase activity [GO:0071713]; protein heterodimerization activity [GO:0046982] GO:0005737; GO:0016805; GO:0046657; GO:0046982; GO:0071713 +P25553 ALDA_ECOLI Lactaldehyde dehydrogenase (EC 1.2.1.22) (Aldehyde dehydrogenase A) (Glycolaldehyde dehydrogenase) (EC 1.2.1.21) aldA ald b1415 JW1412 ald aldA 52,273 L-fucose catabolic process [GO:0042355]; rhamnose catabolic process [GO:0019301] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; glycolaldehyde dehydrogenase activity [GO:0050569]; identical protein binding [GO:0042802]; lactaldehyde dehydrogenase activity [GO:0008911]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777]; L-fucose catabolic process [GO:0042355]; rhamnose catabolic process [GO:0019301] glycolaldehyde dehydrogenase activity [GO:0050569]; identical protein binding [GO:0042802]; lactaldehyde dehydrogenase activity [GO:0008911]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777] GO:0004777; GO:0005829; GO:0008911; GO:0019301; GO:0032991; GO:0042355; GO:0042802; GO:0050569 +P0AE12 AMN_ECOLI AMP nucleosidase (EC 3.2.2.4) amn b1982 JW1963 amn 53,995 AMP salvage [GO:0044209]; nucleoside metabolic process [GO:0009116] cytosol [GO:0005829] cytosol [GO:0005829]; AMP nucleosidase activity [GO:0008714]; AMP salvage [GO:0044209]; nucleoside metabolic process [GO:0009116] AMP nucleosidase activity [GO:0008714] GO:0005829; GO:0008714; GO:0009116; GO:0044209 +P0AB65 ACYP_ECOLI Acylphosphatase (EC 3.6.1.7) (Acylphosphate phosphohydrolase) yccX b0968 JW5131 yccX 10,300 response to heat [GO:0009408] acylphosphatase activity [GO:0003998]; response to heat [GO:0009408] acylphosphatase activity [GO:0003998] GO:0003998; GO:0009408 +P60844 AQPZ_ECOLI Aquaporin Z (Bacterial nodulin-like intrinsic protein) aqpZ bniP b0875 JW0859 bniP aqpZ 23,703 cellular water homeostasis [GO:0009992]; response to osmotic stress [GO:0006970]; water transport [GO:0006833] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; water channel activity [GO:0015250]; cellular water homeostasis [GO:0009992]; response to osmotic stress [GO:0006970]; water transport [GO:0006833] identical protein binding [GO:0042802]; water channel activity [GO:0015250] GO:0005886; GO:0005887; GO:0006833; GO:0006970; GO:0009992; GO:0015250; GO:0016021; GO:0042802 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:10487750, ECO:0000269|PubMed:10518952}; Multi-pass membrane protein {ECO:0000269|PubMed:10487750, ECO:0000269|PubMed:10518952}. +P0AE28 AROM_ECOLI Protein AroM aroM b0390 JW0381 aroM 24,917 +P00968 CARB_ECOLI Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) (Carbamoyl-phosphate synthetase ammonia chain) carB pyrA b0033 JW0031 pyrA carB 117,842 'de novo' UMP biosynthetic process [GO:0044205]; arginine biosynthetic process [GO:0006526]; cellular amino acid biosynthetic process [GO:0008652]; glutamine metabolic process [GO:0006541]; nitrogen compound metabolic process [GO:0006807]; pyrimidine nucleobase biosynthetic process [GO:0019856] carbamoyl-phosphate synthase complex [GO:0005951]; cytoplasm [GO:0005737]; cytosol [GO:0005829] carbamoyl-phosphate synthase complex [GO:0005951]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; amino acid binding [GO:0016597]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (ammonia) activity [GO:0004087]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; 'de novo' UMP biosynthetic process [GO:0044205]; arginine biosynthetic process [GO:0006526]; cellular amino acid biosynthetic process [GO:0008652]; glutamine metabolic process [GO:0006541]; nitrogen compound metabolic process [GO:0006807]; pyrimidine nucleobase biosynthetic process [GO:0019856] amino acid binding [GO:0016597]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (ammonia) activity [GO:0004087]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166] GO:0000166; GO:0004087; GO:0004088; GO:0005524; GO:0005737; GO:0005829; GO:0005951; GO:0006526; GO:0006541; GO:0006807; GO:0008652; GO:0016597; GO:0019856; GO:0044205; GO:0046872 +P63264 CBPM_ECOLI Chaperone modulatory protein CbpM cbpM yccD b0999 JW0984 yccD cbpM 11,512 enzyme inhibitor activity [GO:0004857] enzyme inhibitor activity [GO:0004857] GO:0004857 +P0A6G7 CLPP_ECOLI ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Caseinolytic protease) (Endopeptidase Clp) (Heat shock protein F21.5) (Protease Ti) clpP lopP b0437 JW0427 lopP clpP 23,187 positive regulation of programmed cell death [GO:0043068]; proteasomal protein catabolic process [GO:0010498]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; proteolysis [GO:0006508]; response to heat [GO:0009408]; response to radiation [GO:0009314]; response to temperature stimulus [GO:0009266] cytosol [GO:0005829]; endopeptidase Clp complex [GO:0009368]; HslUV protease complex [GO:0009376]; membrane [GO:0016020] cytosol [GO:0005829]; endopeptidase Clp complex [GO:0009368]; HslUV protease complex [GO:0009376]; membrane [GO:0016020]; ATP-dependent peptidase activity [GO:0004176]; ATPase binding [GO:0051117]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; positive regulation of programmed cell death [GO:0043068]; proteasomal protein catabolic process [GO:0010498]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; proteolysis [GO:0006508]; response to heat [GO:0009408]; response to radiation [GO:0009314]; response to temperature stimulus [GO:0009266] ATPase binding [GO:0051117]; ATP-dependent peptidase activity [GO:0004176]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] GO:0004176; GO:0004252; GO:0005829; GO:0006508; GO:0006515; GO:0008236; GO:0009266; GO:0009314; GO:0009368; GO:0009376; GO:0009408; GO:0010498; GO:0016020; GO:0042802; GO:0043068; GO:0051117 SUBCELLULAR LOCATION: Cytoplasm. +P77202 DSBG_ECOLI Thiol:disulfide interchange protein DsbG dsbG ybdP b0604 JW0597 ybdP dsbG 27,495 chaperone-mediated protein folding [GO:0061077] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; protein disulfide isomerase activity [GO:0003756]; chaperone-mediated protein folding [GO:0061077] protein disulfide isomerase activity [GO:0003756] GO:0003756; GO:0030288; GO:0061077 SUBCELLULAR LOCATION: Periplasm. +P0AE08 AHPC_ECOLI Alkyl hydroperoxide reductase C (EC 1.11.1.26) (Alkyl hydroperoxide reductase protein C22) (Peroxiredoxin) (SCRP-23) (Sulfate starvation-induced protein 8) (SSI8) (Thioredoxin peroxidase) ahpC b0605 JW0598 ahpC 20,761 cell redox homeostasis [GO:0045454]; cellular response to sulfate starvation [GO:0009970]; response to alkyl hydroperoxide [GO:0033195]; response to hydroperoxide [GO:0033194]; siderophore biosynthetic process [GO:0019290] alkyl hydroperoxide reductase complex [GO:0009321]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] alkyl hydroperoxide reductase complex [GO:0009321]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; alkylhydroperoxide reductase activity [GO:0102039]; hydroperoxide reductase activity [GO:0032843]; identical protein binding [GO:0042802]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; peroxidase activity [GO:0004601]; peroxiredoxin activity [GO:0051920]; cell redox homeostasis [GO:0045454]; cellular response to sulfate starvation [GO:0009970]; response to alkyl hydroperoxide [GO:0033195]; response to hydroperoxide [GO:0033194]; siderophore biosynthetic process [GO:0019290] alkylhydroperoxide reductase activity [GO:0102039]; hydroperoxide reductase activity [GO:0032843]; identical protein binding [GO:0042802]; oxidoreductase activity, acting on peroxide as acceptor [GO:0016684]; peroxidase activity [GO:0004601]; peroxiredoxin activity [GO:0051920] GO:0004601; GO:0005737; GO:0005829; GO:0009321; GO:0009970; GO:0016020; GO:0016684; GO:0019290; GO:0032843; GO:0033194; GO:0033195; GO:0042802; GO:0045454; GO:0051920; GO:0102039 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7499381}. +P51981 AEEP_ECOLI L-Ala-D/L-Glu epimerase (AE epimerase) (AEE) (EC 5.1.1.20) ycjG ycjH b1325 JW1318 ycjH ycjG 34,674 cellular amino acid catabolic process [GO:0009063]; cell wall organization [GO:0071555]; peptidoglycan turnover [GO:0009254] L-Ala-D/L-Glu epimerase activity [GO:0103031]; metal ion binding [GO:0046872]; racemase and epimerase activity, acting on amino acids and derivatives [GO:0016855]; cell wall organization [GO:0071555]; cellular amino acid catabolic process [GO:0009063]; peptidoglycan turnover [GO:0009254] L-Ala-D/L-Glu epimerase activity [GO:0103031]; metal ion binding [GO:0046872]; racemase and epimerase activity, acting on amino acids and derivatives [GO:0016855] GO:0009063; GO:0009254; GO:0016855; GO:0046872; GO:0071555; GO:0103031 +P77624 ARCM_ECOLI Carbamate kinase-like protein YahI yahI b0323 JW0315 yahI 33,931 arginine deiminase pathway [GO:0019546] cytosol [GO:0005829] cytosol [GO:0005829]; carbamate kinase activity [GO:0008804]; arginine deiminase pathway [GO:0019546] carbamate kinase activity [GO:0008804] GO:0005829; GO:0008804; GO:0019546 +P09551 ARGT_ECOLI Lysine/arginine/ornithine-binding periplasmic protein (LAO-binding protein) argT b2310 JW2307 argT 27,992 cellular response to nitrogen starvation [GO:0006995]; cellular response to starvation [GO:0009267]; cellular response to zinc ion [GO:0071294]; L-lysine transport [GO:1902022]; ornithine transport [GO:0015822] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; cellular response to nitrogen starvation [GO:0006995]; cellular response to starvation [GO:0009267]; cellular response to zinc ion [GO:0071294]; L-lysine transport [GO:1902022]; ornithine transport [GO:0015822] GO:0006995; GO:0009267; GO:0015822; GO:0030288; GO:0071294; GO:1902022 SUBCELLULAR LOCATION: Periplasm. +P0A962 ASPG1_ECOLI L-asparaginase 1 (EC 3.5.1.1) (L-asparaginase I) (L-ASNase I) (L-asparagine amidohydrolase I) ansA b1767 JW1756 ansA 37,127 asparagine catabolic process via L-aspartate [GO:0033345] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; asparaginase activity [GO:0004067]; identical protein binding [GO:0042802]; asparagine catabolic process via L-aspartate [GO:0033345] asparaginase activity [GO:0004067]; identical protein binding [GO:0042802] GO:0004067; GO:0005737; GO:0005829; GO:0033345; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm. +P24242 ASCG_ECOLI HTH-type transcriptional regulator AscG (Cryptic asc operon repressor) ascG b2714 JW5434 ascG 36,813 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006351; GO:0006355; GO:0043565; GO:0045892 +P06864 BGA2_ECOLI Evolved beta-galactosidase subunit alpha (Beta-gal) (EC 3.2.1.23) (Lactase) ebgA b3076 JW5511 ebgA 117,879 lactose catabolic process [GO:0005990] beta-galactosidase complex [GO:0009341] beta-galactosidase complex [GO:0009341]; beta-galactosidase activity [GO:0004565]; carbohydrate binding [GO:0030246]; lactose catabolic process [GO:0005990] beta-galactosidase activity [GO:0004565]; carbohydrate binding [GO:0030246] GO:0004565; GO:0005990; GO:0009341; GO:0030246 +P75989 BLUR_ECOLI HTH-type transcriptional repressor BluR bluR ycgE b1162 JW1149 ycgE bluR 28,265 negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0045892 +P0AC02 BAMD_ECOLI Outer membrane protein assembly factor BamD bamD yfiO b2595 JW2577 yfiO bamD 27,829 Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; protein insertion into membrane [GO:0051205] Bam protein complex [GO:1990063]; cell outer membrane [GO:0009279] Bam protein complex [GO:1990063]; cell outer membrane [GO:0009279]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; protein insertion into membrane [GO:0051205] GO:0009279; GO:0043165; GO:0051205; GO:1990063 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_00922, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:26900875, ECO:0000269|PubMed:26901871}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_00922, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:27686148}. +P37653 BCSA_ECOLI Cellulose synthase catalytic subunit [UDP-forming] (EC 2.4.1.12) bcsA yhjO yhjP b3533 JW5665 yhjO yhjP bcsA 99,785 bacterial cellulose biosynthetic process [GO:0090540]; UDP-glucose metabolic process [GO:0006011] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cellulose synthase (UDP-forming) activity [GO:0016760]; cyclic-di-GMP binding [GO:0035438]; transferase activity, transferring hexosyl groups [GO:0016758]; bacterial cellulose biosynthetic process [GO:0090540]; UDP-glucose metabolic process [GO:0006011] cellulose synthase (UDP-forming) activity [GO:0016760]; cyclic-di-GMP binding [GO:0035438]; transferase activity, transferring hexosyl groups [GO:0016758] GO:0005886; GO:0006011; GO:0016021; GO:0016758; GO:0016760; GO:0035438; GO:0090540 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P31553 CAIT_ECOLI L-carnitine/gamma-butyrobetaine antiporter caiT yaaP b0040 JW0039 yaaP caiT 56,587 4-(trimethylammonio)butanoate transport [GO:1900751]; carnitine metabolic process [GO:0009437]; carnitine transport [GO:0015879] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; (R)-carnitine:4-(trimethylammonio)butanoate antiporter activity [GO:0044667]; carnitine transmembrane transporter activity [GO:0015226]; transmembrane transporter activity [GO:0022857]; 4-(trimethylammonio)butanoate transport [GO:1900751]; carnitine metabolic process [GO:0009437]; carnitine transport [GO:0015879] (R)-carnitine:4-(trimethylammonio)butanoate antiporter activity [GO:0044667]; carnitine transmembrane transporter activity [GO:0015226]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0009437; GO:0015226; GO:0015879; GO:0016021; GO:0022857; GO:0044667; GO:1900751 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01049, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01049, ECO:0000269|PubMed:15919996}. +P37794 CHBG_ECOLI Chitooligosaccharide deacetylase ChbG (COD) (EC 3.5.1.105) (Chitin disaccharide deacetylase) (Chitobiose deacetylase) (Chitobiose-6P deacetylase) (Chitotriose deacetylase) (Chitotriose-6P deacetylase) chbG ydjC b1733 JW1722 ydjC chbG 27,774 chitin catabolic process [GO:0006032]; diacetylchitobiose catabolic process [GO:0052777]; polysaccharide catabolic process [GO:0000272] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; chitin disaccharide deacetylase activity [GO:0036311]; deacetylase activity [GO:0019213]; metal ion binding [GO:0046872]; chitin catabolic process [GO:0006032]; diacetylchitobiose catabolic process [GO:0052777]; polysaccharide catabolic process [GO:0000272] chitin disaccharide deacetylase activity [GO:0036311]; deacetylase activity [GO:0019213]; metal ion binding [GO:0046872] GO:0000272; GO:0005737; GO:0006032; GO:0019213; GO:0036311; GO:0046872; GO:0052777 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22797760}. +P0ABM5 CCMD_ECOLI Heme exporter protein D (Cytochrome c-type biogenesis protein CcmD) ccmD yojM b2198 JW2186 yojM ccmD 7,745 cytochrome complex assembly [GO:0017004]; heme transport [GO:0015886] integral component of membrane [GO:0016021]; intrinsic component of the cytoplasmic side of the plasma membrane [GO:0031235] integral component of membrane [GO:0016021]; intrinsic component of the cytoplasmic side of the plasma membrane [GO:0031235]; cytochrome complex assembly [GO:0017004]; heme transport [GO:0015886] GO:0015886; GO:0016021; GO:0017004; GO:0031235 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P0ABM9 CCMH_ECOLI Cytochrome c-type biogenesis protein CcmH ccmH yejP b2194 JW2182 yejP ccmH 39,089 cytochrome c-heme linkage via heme-L-cysteine [GO:0018378]; cytochrome complex assembly [GO:0017004] integral component of membrane [GO:0016021]; intrinsic component of periplasmic side of plasma membrane [GO:0031237]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; intrinsic component of periplasmic side of plasma membrane [GO:0031237]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; protein disulfide oxidoreductase activity [GO:0015035]; cytochrome c-heme linkage via heme-L-cysteine [GO:0018378]; cytochrome complex assembly [GO:0017004] metal ion binding [GO:0046872]; protein disulfide oxidoreductase activity [GO:0015035] GO:0005886; GO:0015035; GO:0016021; GO:0017004; GO:0018378; GO:0031237; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P36566 CMOM_ECOLI tRNA 5-carboxymethoxyuridine methyltransferase (EC 2.1.1.-) (cmo5U methyltransferase) cmoM smtA ycbD b0921 JW0904 smtA ycbD cmoM 29,814 tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] tRNA 5-carboxymethoxyuridine methyltransferase activity [GO:0097697]; tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] tRNA 5-carboxymethoxyuridine methyltransferase activity [GO:0097697] GO:0002098; GO:0030488; GO:0097697 +P75919 CLSC_ECOLI Cardiolipin synthase C (CL synthase) (EC 2.7.8.-) clsC ymdC b1046 JW5150 ymdC clsC 53,666 cardiolipin biosynthetic process [GO:0032049] phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity [GO:0090483]; cardiolipin biosynthetic process [GO:0032049] phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity [GO:0090483] GO:0032049; GO:0090483 +P0AEW4 CPDA_ECOLI 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (3',5'-cyclic AMP phosphodiesterase) (cAMP phosphodiesterase) (EC 3.1.4.53) cpdA icc b3032 JW3000 icc cpdA 30,938 cell wall modification [GO:0042545] 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; ferrous iron binding [GO:0008198]; nucleotide binding [GO:0000166]; cell wall modification [GO:0042545] 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; ferrous iron binding [GO:0008198]; nucleotide binding [GO:0000166] GO:0000166; GO:0004115; GO:0008198; GO:0042545 +P38038 CYSJ_ECOLI Sulfite reductase [NADPH] flavoprotein alpha-component (SiR-FP) (EC 1.8.1.2) cysJ b2764 JW2734 cysJ 66,270 cysteine biosynthetic process [GO:0019344]; hydrogen sulfide biosynthetic process [GO:0070814]; sulfate assimilation [GO:0000103] cytosol [GO:0005829]; sulfite reductase complex (NADPH) [GO:0009337] cytosol [GO:0005829]; sulfite reductase complex (NADPH) [GO:0009337]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADP+ binding [GO:0070401]; oxidoreductase activity [GO:0016491]; riboflavin reductase (NADPH) activity [GO:0042602]; sulfite reductase (NADPH) activity [GO:0004783]; cysteine biosynthetic process [GO:0019344]; hydrogen sulfide biosynthetic process [GO:0070814]; sulfate assimilation [GO:0000103] flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; NADP+ binding [GO:0070401]; oxidoreductase activity [GO:0016491]; riboflavin reductase (NADPH) activity [GO:0042602]; sulfite reductase (NADPH) activity [GO:0004783] GO:0000103; GO:0004783; GO:0005829; GO:0009337; GO:0010181; GO:0016491; GO:0019344; GO:0042602; GO:0050660; GO:0070401; GO:0070814 +P09549 DEDD_ECOLI Cell division protein DedD dedD b2314 JW5378 dedD 22,938 cytokinetic process [GO:0032506] cell division site [GO:0032153]; cell septum [GO:0030428]; integral component of plasma membrane [GO:0005887] cell division site [GO:0032153]; cell septum [GO:0030428]; integral component of plasma membrane [GO:0005887]; peptidoglycan binding [GO:0042834]; cytokinetic process [GO:0032506] peptidoglycan binding [GO:0042834] GO:0005887; GO:0030428; GO:0032153; GO:0032506; GO:0042834 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02022, ECO:0000305}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02022}. Note=Localizes at the septal ring. {ECO:0000255|HAMAP-Rule:MF_02022, ECO:0000269|PubMed:19684127, ECO:0000269|PubMed:19880599}. +P0ABS1 DKSA_ECOLI RNA polymerase-binding transcription factor DksA (DnaK suppressor protein) dksA b0145 JW0141 dksA 17,528 double-strand break repair [GO:0006302]; regulation of gene expression [GO:0010468] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; zinc ion binding [GO:0008270]; double-strand break repair [GO:0006302]; regulation of gene expression [GO:0010468] zinc ion binding [GO:0008270] GO:0005737; GO:0005829; GO:0006302; GO:0008270; GO:0010468 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00926, ECO:0000269|PubMed:16858726}. +P18776 DMSB_ECOLI Anaerobic dimethyl sulfoxide reductase chain B (DMSO reductase iron-sulfur subunit) dmsB b0895 JW0878 dmsB 22,869 anaerobic respiration [GO:0009061] dimethyl sulfoxide reductase complex [GO:0009390]; intrinsic component of periplasmic side of plasma membrane [GO:0031237] dimethyl sulfoxide reductase complex [GO:0009390]; intrinsic component of periplasmic side of plasma membrane [GO:0031237]; 4 iron, 4 sulfur cluster binding [GO:0051539]; dimethyl sulfoxide reductase activity [GO:0009389]; metal ion binding [GO:0046872]; anaerobic respiration [GO:0009061] 4 iron, 4 sulfur cluster binding [GO:0051539]; dimethyl sulfoxide reductase activity [GO:0009389]; metal ion binding [GO:0046872] GO:0009061; GO:0009389; GO:0009390; GO:0031237; GO:0046872; GO:0051539 +P75908 DGCT_ECOLI Probable diguanylate cyclase DgcT (DGC) (EC 2.7.7.65) dgcT ycdT b1025 JW5143 ycdT dgcT 51,783 negative regulation of cellular component movement [GO:0051271]; single-species submerged biofilm formation [GO:0090609] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; negative regulation of cellular component movement [GO:0051271]; single-species submerged biofilm formation [GO:0090609] diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872] GO:0005525; GO:0005886; GO:0016021; GO:0046872; GO:0051271; GO:0052621; GO:0090609 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P04395 3MG2_ECOLI DNA-3-methyladenine glycosylase 2 (EC 3.2.2.21) (3-methyladenine-DNA glycosylase II, inducible) (TAG II) (DNA-3-methyladenine glycosidase II) (DNA-3-methyladenine glycosylase II) alkA aidA b2068 JW2053 aidA alkA 31,393 base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; cellular response to DNA damage stimulus [GO:0006974]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA repair [GO:0006281] cytoplasm [GO:0005737]; protein-DNA complex [GO:0032993] cytoplasm [GO:0005737]; protein-DNA complex [GO:0032993]; alkylated DNA binding [GO:0032131]; alkylbase DNA N-glycosylase activity [GO:0003905]; DNA-3-methyladenine glycosylase activity [GO:0008725]; DNA-3-methylguanine glycosylase activity [GO:0052822]; DNA-7-methyladenine glycosylase activity [GO:0052821]; DNA-7-methylguanine glycosylase activity [GO:0043916]; base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; cellular response to DNA damage stimulus [GO:0006974]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA repair [GO:0006281] alkylated DNA binding [GO:0032131]; alkylbase DNA N-glycosylase activity [GO:0003905]; DNA-3-methyladenine glycosylase activity [GO:0008725]; DNA-3-methylguanine glycosylase activity [GO:0052822]; DNA-7-methyladenine glycosylase activity [GO:0052821]; DNA-7-methylguanine glycosylase activity [GO:0043916] GO:0003905; GO:0005737; GO:0006281; GO:0006284; GO:0006285; GO:0006307; GO:0006974; GO:0008725; GO:0032131; GO:0032993; GO:0043916; GO:0052821; GO:0052822 +P46482 AAEA_ECOLI p-hydroxybenzoic acid efflux pump subunit AaeA (pHBA efflux pump protein A) aaeA yhcQ b3241 JW3210 yhcQ aaeA 34,775 carboxylic acid transport [GO:0046942] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; carboxylic acid transport [GO:0046942] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857; GO:0046942 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01544}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01544}. +P39180 AG43_ECOLI Antigen 43 (AG43) (Fluffing protein) [Cleaved into: Antigen 43 alpha chain; Antigen 43 beta chain] flu yeeQ yzzX b2000 JW1982 yeeQ yzzX flu 106,825 cell outer membrane [GO:0009279]; cell surface [GO:0009986]; extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; periplasmic space [GO:0042597] cell outer membrane [GO:0009279]; cell surface [GO:0009986]; extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; periplasmic space [GO:0042597] GO:0005576; GO:0009279; GO:0009986; GO:0016021; GO:0042597 SUBCELLULAR LOCATION: [Antigen 43]: Periplasm {ECO:0000250}.; SUBCELLULAR LOCATION: [Antigen 43 alpha chain]: Secreted. Cell surface {ECO:0000269|PubMed:22466966}. Note=The cell surface component is about 60 kDa and can be released by mild heat treatment (PubMed:22466966).; SUBCELLULAR LOCATION: [Antigen 43 beta chain]: Cell outer membrane {ECO:0000305|PubMed:25341963}; Multi-pass membrane protein {ECO:0000305}. Note=May form a beta-barrel. +P42906 AGAA_ECOLI Putative N-acetylgalactosamine-6-phosphate deacetylase (Aga-6-P deacetylase) (EC 3.5.1.-) agaA b3135 JW5527 agaA 17,519 carbohydrate metabolic process [GO:0005975]; N-acetylglucosamine metabolic process [GO:0006044] N-acetylgalactosamine-6-phosphate deacetylase activity [GO:0047419]; N-acetylglucosamine-6-phosphate deacetylase activity [GO:0008448]; carbohydrate metabolic process [GO:0005975]; N-acetylglucosamine metabolic process [GO:0006044] N-acetylgalactosamine-6-phosphate deacetylase activity [GO:0047419]; N-acetylglucosamine-6-phosphate deacetylase activity [GO:0008448] GO:0005975; GO:0006044; GO:0008448; GO:0047419 +P00805 ASPG2_ECOLI L-asparaginase 2 (EC 3.5.1.1) (L-asparaginase II) (L-ASNase II) (L-asparagine amidohydrolase II) (Colaspase) ansB b2957 JW2924 ansB 36,851 asparagine catabolic process [GO:0006530] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; protein-containing complex [GO:0032991] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; protein-containing complex [GO:0032991]; asparaginase activity [GO:0004067]; identical protein binding [GO:0042802]; asparagine catabolic process [GO:0006530] asparaginase activity [GO:0004067]; identical protein binding [GO:0042802] GO:0004067; GO:0006530; GO:0030288; GO:0032991; GO:0042597; GO:0042802 SUBCELLULAR LOCATION: Periplasm. +P0A901 BLC_ECOLI Outer membrane lipoprotein Blc blc yjeL b4149 JW4110 yjeL blc 19,852 cellular response to DNA damage stimulus [GO:0006974]; lipid metabolic process [GO:0006629]; response to reactive oxygen species [GO:0000302] cell outer membrane [GO:0009279]; cytoplasm [GO:0005737] cell outer membrane [GO:0009279]; cytoplasm [GO:0005737]; lipid binding [GO:0008289]; cellular response to DNA damage stimulus [GO:0006974]; lipid metabolic process [GO:0006629]; response to reactive oxygen species [GO:0000302] lipid binding [GO:0008289] GO:0000302; GO:0005737; GO:0006629; GO:0006974; GO:0008289; GO:0009279 SUBCELLULAR LOCATION: Cell outer membrane; Lipid-anchor. +P0ADP5 BIOP_ECOLI Biotin transporter (Plasmamembrane biotin transport protein) bioP yigM b3827 JW3803 yigM bioP 33,727 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|Ref.5}; Multi-pass membrane protein {ECO:0000255}. +P0AB40 BHSA_ECOLI Multiple stress resistance protein BhsA (Copper-induced outer membrane component) bhsA comC ycfR b1112 JW1098 comC ycfR bhsA 8,815 response to copper ion [GO:0046688] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; response to copper ion [GO:0046688] GO:0009279; GO:0046688 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:22089859}. +P39404 BGLJ_ECOLI Transcriptional activator protein BglJ bglJ yjjR b4366 JW5955 yjjR bglJ 25,622 positive regulation of transcription, DNA-templated [GO:0045893]; response to radiation [GO:0009314] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; positive regulation of transcription, DNA-templated [GO:0045893]; response to radiation [GO:0009314] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0009314; GO:0045893 +P33363 BGLX_ECOLI Periplasmic beta-glucosidase (EC 3.2.1.21) (Beta-D-glucoside glucohydrolase) (Cellobiase) (Gentiobiase) bglX yohA b2132 JW2120 yohA bglX 83,460 glucan catabolic process [GO:0009251] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; beta-glucosidase activity [GO:0008422]; glucosidase activity [GO:0015926]; scopolin beta-glucosidase activity [GO:0102483]; glucan catabolic process [GO:0009251] beta-glucosidase activity [GO:0008422]; glucosidase activity [GO:0015926]; scopolin beta-glucosidase activity [GO:0102483] GO:0008422; GO:0009251; GO:0015926; GO:0030288; GO:0042597; GO:0102483 SUBCELLULAR LOCATION: Periplasm. +P75975 CROE_ECOLI Prophage transcriptional regulatory protein (Putative lambdoid prophage e14 transcriptional regulatory protein) croE ymfT b1146 JW5169 ymfT croE 7,402 DNA binding [GO:0003677] DNA binding [GO:0003677] GO:0003677 +P00861 DCDA_ECOLI Diaminopimelate decarboxylase (DAP decarboxylase) (DAPDC) (EC 4.1.1.20) lysA b2838 JW2806 lysA 46,177 lysine biosynthetic process via diaminopimelate [GO:0009089] diaminopimelate decarboxylase activity [GO:0008836]; pyridoxal phosphate binding [GO:0030170]; lysine biosynthetic process via diaminopimelate [GO:0009089] diaminopimelate decarboxylase activity [GO:0008836]; pyridoxal phosphate binding [GO:0030170] GO:0008836; GO:0009089; GO:0030170 +P64550 ALAE_ECOLI L-alanine exporter AlaE alaE ygaW b2670 JW2645 ygaW alaE 16,949 amino acid export across plasma membrane [GO:0032973]; L-alanine transport [GO:0015808] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; L-amino acid efflux transmembrane transporter activity [GO:0034639]; solute:proton antiporter activity [GO:0015299]; amino acid export across plasma membrane [GO:0032973]; L-alanine transport [GO:0015808] L-amino acid efflux transmembrane transporter activity [GO:0034639]; solute:proton antiporter activity [GO:0015299] GO:0005886; GO:0005887; GO:0015299; GO:0015808; GO:0032973; GO:0034639 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00914, ECO:0000269|PubMed:21531828}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00914, ECO:0000269|PubMed:21531828}. +P77434 ALAC_ECOLI Glutamate-pyruvate aminotransferase AlaC (EC 2.6.1.2) alaC yfdZ b2379 JW2376 yfdZ alaC 46,216 alanine biosynthetic process [GO:0006523]; D-alanine biosynthetic process [GO:0030632]; L-alanine biosynthetic process from pyruvate [GO:0019272] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; L-alanine:2-oxoglutarate aminotransferase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]; alanine biosynthetic process [GO:0006523]; D-alanine biosynthetic process [GO:0030632]; L-alanine biosynthetic process from pyruvate [GO:0019272] L-alanine:2-oxoglutarate aminotransferase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] GO:0004021; GO:0005737; GO:0006523; GO:0008483; GO:0019272; GO:0030170; GO:0030632 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P32705 ACTP_ECOLI Cation/acetate symporter ActP (Acetate permease) (Acetate transporter ActP) actP yjcG b4067 JW4028 yjcG actP 59,197 plasma membrane acetate transport [GO:0006847]; sodium ion transport [GO:0006814]; tellurite transport [GO:0015710] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; acetate transmembrane transporter activity [GO:0015123]; glycolate transmembrane transporter activity [GO:0043879]; symporter activity [GO:0015293]; tellurite transmembrane transporter activity [GO:0015654]; plasma membrane acetate transport [GO:0006847]; sodium ion transport [GO:0006814]; tellurite transport [GO:0015710] acetate transmembrane transporter activity [GO:0015123]; glycolate transmembrane transporter activity [GO:0043879]; symporter activity [GO:0015293]; tellurite transmembrane transporter activity [GO:0015654] GO:0005886; GO:0005887; GO:0006814; GO:0006847; GO:0015123; GO:0015293; GO:0015654; GO:0015710; GO:0043879 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137}. +P0A8S1 ARGP_ECOLI HTH-type transcriptional regulator ArgP (Inhibitor of chromosome initiation) (OriC replication inhibitor) argP iciA b2916 JW2883 iciA argP 33,472 negative regulation of DNA-dependent DNA replication initiation [GO:0032297]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] bent DNA binding [GO:0003681]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; negative regulation of DNA-dependent DNA replication initiation [GO:0032297]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] bent DNA binding [GO:0003681]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003681; GO:0003700; GO:0006355; GO:0032297; GO:0043565; GO:0045892; GO:0045893 +P0A6E4 ASSY_ECOLI Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) argG b3172 JW3140 argG 49,898 arginine biosynthetic process [GO:0006526]; argininosuccinate metabolic process [GO:0000053]; urea cycle [GO:0000050] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; argininosuccinate synthase activity [GO:0004055]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; arginine biosynthetic process [GO:0006526]; argininosuccinate metabolic process [GO:0000053]; urea cycle [GO:0000050] argininosuccinate synthase activity [GO:0004055]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803] GO:0000050; GO:0000053; GO:0004055; GO:0005524; GO:0005737; GO:0005829; GO:0006526; GO:0042802; GO:0042803 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P07639 AROB_ECOLI 3-dehydroquinate synthase (DHQS) (EC 4.2.3.4) aroB b3389 JW3352 aroB 38,881 aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 3-dehydroquinate synthase activity [GO:0003856]; NAD+ binding [GO:0070403]; zinc ion binding [GO:0008270]; aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] 3-dehydroquinate synthase activity [GO:0003856]; NAD+ binding [GO:0070403]; zinc ion binding [GO:0008270] GO:0003856; GO:0005737; GO:0008270; GO:0008652; GO:0009073; GO:0009423; GO:0070403 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00110}. +P77690 ARNB_ECOLI UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (EC 2.6.1.87) (Polymyxin resistance protein PmrH) (UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase) (UDP-Ara4O aminotransferase) (UDP-4-amino-4-deoxy-L-arabinose aminotransferase) arnB pmrH yfbE b2253 JW5372 pmrH yfbE arnB 42,238 lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; polysaccharide biosynthetic process [GO:0000271]; response to antibiotic [GO:0046677] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]; UDP-4-amino-4-deoxy-L-arabinose aminotransferase [GO:0099620]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; polysaccharide biosynthetic process [GO:0000271]; response to antibiotic [GO:0046677] pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]; UDP-4-amino-4-deoxy-L-arabinose aminotransferase [GO:0099620] GO:0000271; GO:0005737; GO:0008483; GO:0009103; GO:0009245; GO:0030170; GO:0046677; GO:0099620 +Q47377 ARNE_ECOLI Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE (L-Ara4N-phosphoundecaprenol flippase subunit ArnE) (Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE) arnE pmrL yfbW b4544 JW2252 pmrL yfbW arnE 12,192 carbohydrate derivative transport [GO:1901264]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; response to iron(III) ion [GO:0010041]; transmembrane transport [GO:0055085] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; carbohydrate derivative transmembrane transporter activity [GO:1901505]; transmembrane transporter activity [GO:0022857]; carbohydrate derivative transport [GO:1901264]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; response to iron(III) ion [GO:0010041]; transmembrane transport [GO:0055085] carbohydrate derivative transmembrane transporter activity [GO:1901505]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0009103; GO:0009245; GO:0010041; GO:0022857; GO:0055085; GO:1901264; GO:1901505 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AFP2 ATL_ECOLI DNA base-flipping protein (Alkyltransferase-like protein ATL) atl ybaZ b0454 JW0444 ybaZ atl 14,450 DNA repair [GO:0006281] catalytic activity [GO:0003824]; damaged DNA binding [GO:0003684]; enzyme binding [GO:0019899]; DNA repair [GO:0006281] catalytic activity [GO:0003824]; damaged DNA binding [GO:0003684]; enzyme binding [GO:0019899] GO:0003684; GO:0003824; GO:0006281; GO:0019899 +P0ABB0 ATPA_ECOLI ATP synthase subunit alpha (EC 7.1.2.2) (ATP synthase F1 sector subunit alpha) (F-ATPase subunit alpha) atpA papA uncA b3734 JW3712 papA uncA atpA 55,222 ATP synthesis coupled proton transport [GO:0015986] membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261] membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP synthesis coupled proton transport [GO:0015986] ADP binding [GO:0043531]; ATP binding [GO:0005524]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933] GO:0005524; GO:0005886; GO:0015986; GO:0016020; GO:0043531; GO:0045261; GO:0046933; GO:0046961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01346, ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01346, ECO:0000269|PubMed:16079137}. +P06129 BTUB_ECOLI Vitamin B12 transporter BtuB (Cobalamin receptor) (Outer membrane cobalamin translocator) btuB bfe cer dcrC b3966 JW3938 bfe cer dcrC btuB 68,407 cobalamin transport [GO:0015889]; ion transmembrane transport [GO:0034220] integral component of membrane [GO:0016021]; intrinsic component of cell outer membrane [GO:0031230]; pore complex [GO:0046930] integral component of membrane [GO:0016021]; intrinsic component of cell outer membrane [GO:0031230]; pore complex [GO:0046930]; ABC-type vitamin B12 transporter activity [GO:0015420]; metal ion binding [GO:0046872]; porin activity [GO:0015288]; protein domain specific binding [GO:0019904]; cobalamin transport [GO:0015889]; ion transmembrane transport [GO:0034220] ABC-type vitamin B12 transporter activity [GO:0015420]; metal ion binding [GO:0046872]; porin activity [GO:0015288]; protein domain specific binding [GO:0019904] GO:0015288; GO:0015420; GO:0015889; GO:0016021; GO:0019904; GO:0031230; GO:0034220; GO:0046872; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:12595710, ECO:0000269|PubMed:12652322, ECO:0000269|PubMed:2687240, ECO:0000269|PubMed:2982793}; Multi-pass membrane protein {ECO:0000269|PubMed:12595710, ECO:0000269|PubMed:12652322, ECO:0000269|PubMed:2687240, ECO:0000269|PubMed:2982793}. +P13000 BIOD1_ECOLI ATP-dependent dethiobiotin synthetase BioD 1 (EC 6.3.3.3) (DTB synthetase 1) (DTBS 1) (Dethiobiotin synthase 1) bioD1 b0778 JW0761 bioD1 24,140 biotin biosynthetic process [GO:0009102] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; dethiobiotin synthase activity [GO:0004141]; magnesium ion binding [GO:0000287]; biotin biosynthetic process [GO:0009102] ATP binding [GO:0005524]; dethiobiotin synthase activity [GO:0004141]; magnesium ion binding [GO:0000287] GO:0000287; GO:0004141; GO:0005524; GO:0005829; GO:0009102 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00336}. +P31572 CAIB_ECOLI L-carnitine CoA-transferase (EC 2.8.3.21) (Crotonobetainyl-CoA:carnitine CoA-transferase) caiB yaaN b0038 JW0037 yaaN caiB 45,127 carnitine catabolic process [GO:0042413] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; carnitine dehydratase activity [GO:0008735]; CoA-transferase activity [GO:0008410]; carnitine catabolic process [GO:0042413] carnitine dehydratase activity [GO:0008735]; CoA-transferase activity [GO:0008410] GO:0005737; GO:0008410; GO:0008735; GO:0042413 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01050}. +P33647 CHPB_ECOLI Endoribonuclease toxin ChpB (EC 3.1.-.-) (Toxin ChpB) (mRNA interferase ChpB) chpB chpBK yjfE b4225 JW4184 chpBK yjfE chpB 12,492 mRNA catabolic process [GO:0006402]; negative regulation of cell growth [GO:0030308]; regulation of mRNA stability [GO:0043488]; rRNA catabolic process [GO:0016075] DNA binding [GO:0003677]; endoribonuclease activity [GO:0004521]; endoribonuclease activity, producing 5'-phosphomonoesters [GO:0016891]; RNA binding [GO:0003723]; mRNA catabolic process [GO:0006402]; negative regulation of cell growth [GO:0030308]; regulation of mRNA stability [GO:0043488]; rRNA catabolic process [GO:0016075] DNA binding [GO:0003677]; endoribonuclease activity [GO:0004521]; endoribonuclease activity, producing 5'-phosphomonoesters [GO:0016891]; RNA binding [GO:0003723] GO:0003677; GO:0003723; GO:0004521; GO:0006402; GO:0016075; GO:0016891; GO:0030308; GO:0043488 +P0ABK2 CYDB_ECOLI Cytochrome bd-I ubiquinol oxidase subunit 2 (EC 7.1.1.7) (Cytochrome bd-I oxidase subunit II) (Cytochrome d ubiquinol oxidase subunit II) cydB cyd-2 b0734 JW0723 cyd-2 cydB 42,453 aerobic electron transport chain [GO:0019646]; oxidative phosphorylation [GO:0006119] cytochrome complex [GO:0070069]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] cytochrome complex [GO:0070069]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [GO:0016682]; aerobic electron transport chain [GO:0019646]; oxidative phosphorylation [GO:0006119] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [GO:0016682] GO:0005886; GO:0005887; GO:0006119; GO:0009055; GO:0016020; GO:0016682; GO:0019646; GO:0020037; GO:0046872; GO:0070069 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15013751, ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:15013751, ECO:0000269|PubMed:16079137}. Note=The displayed topology is based on (PubMed:15013751) not the large scale studies (PubMed:15919996). {ECO:0000269|PubMed:15013751, ECO:0000269|PubMed:15919996}. +P0A6J8 DDLA_ECOLI D-alanine--D-alanine ligase A (EC 6.3.2.4) (D-Ala-D-Ala ligase A) (D-alanylalanine synthetase A) ddlA b0381 JW0372 ddlA 39,316 cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to X-ray [GO:0010165] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; D-alanine-D-alanine ligase activity [GO:0008716]; metal ion binding [GO:0046872]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to X-ray [GO:0010165] ATP binding [GO:0005524]; D-alanine-D-alanine ligase activity [GO:0008716]; metal ion binding [GO:0046872] GO:0005524; GO:0005829; GO:0008360; GO:0008716; GO:0009252; GO:0010165; GO:0046872; GO:0071555 SUBCELLULAR LOCATION: Cytoplasm. +P18775 DMSA_ECOLI Dimethyl sulfoxide reductase DmsA (DMSO reductase) (DMSOR) (Me2SO reductase) (EC 1.8.5.3) dmsA b0894 JW5118 dmsA 90,399 anaerobic respiration [GO:0009061] dimethyl sulfoxide reductase complex [GO:0009390]; intrinsic component of periplasmic side of plasma membrane [GO:0031237]; outer membrane-bounded periplasmic space [GO:0030288] dimethyl sulfoxide reductase complex [GO:0009390]; intrinsic component of periplasmic side of plasma membrane [GO:0031237]; outer membrane-bounded periplasmic space [GO:0030288]; 4 iron, 4 sulfur cluster binding [GO:0051539]; dimethyl sulfoxide reductase activity [GO:0009389]; electron transfer activity [GO:0009055]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; anaerobic respiration [GO:0009061] 4 iron, 4 sulfur cluster binding [GO:0051539]; dimethyl sulfoxide reductase activity [GO:0009389]; electron transfer activity [GO:0009055]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546] GO:0009055; GO:0009061; GO:0009389; GO:0009390; GO:0030151; GO:0030288; GO:0031237; GO:0043546; GO:0051539 SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2170332, ECO:0000269|PubMed:3280546}; Peripheral membrane protein {ECO:0000269|PubMed:2170332, ECO:0000269|PubMed:3280546}; Cytoplasmic side {ECO:0000269|PubMed:2170332, ECO:0000269|PubMed:3280546}. +P31680 DJLA_ECOLI Co-chaperone protein DjlA (DnaJ-like protein DjlA) djlA yabH b0055 JW0054 yabH djlA 30,579 integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; chaperone binding [GO:0051087] chaperone binding [GO:0051087] GO:0005886; GO:0016020; GO:0016021; GO:0051087 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01153, ECO:0000269|PubMed:11106641, ECO:0000269|PubMed:8809778, ECO:0000269|PubMed:9364917}; Single-pass type III membrane protein {ECO:0000255|HAMAP-Rule:MF_01153, ECO:0000269|PubMed:11106641, ECO:0000269|PubMed:8809778, ECO:0000269|PubMed:9364917}. +P0ACB0 DNAB_ECOLI Replicative DNA helicase (EC 3.6.4.12) dnaB groP grpA b4052 JW4012 groP grpA dnaB 52,390 DNA replication [GO:0006260]; DNA replication, synthesis of RNA primer [GO:0006269]; DNA unwinding involved in DNA replication [GO:0006268]; response to ionizing radiation [GO:0010212] cytosol [GO:0005829]; primosome complex [GO:1990077] cytosol [GO:0005829]; primosome complex [GO:1990077]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; helicase activity [GO:0004386]; identical protein binding [GO:0042802]; DNA replication [GO:0006260]; DNA replication, synthesis of RNA primer [GO:0006269]; DNA unwinding involved in DNA replication [GO:0006268]; response to ionizing radiation [GO:0010212] ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; helicase activity [GO:0004386]; identical protein binding [GO:0042802] GO:0003677; GO:0003678; GO:0004386; GO:0005524; GO:0005829; GO:0006260; GO:0006268; GO:0006269; GO:0010212; GO:0042802; GO:1990077 +P32695 DUSA_ECOLI tRNA-dihydrouridine(20/20a) synthase (EC 1.3.1.-) (EC 1.3.1.91) (U20-specific dihydrouridine synthase) (U20-specific Dus) (tRNA-dihydrouridine synthase A) dusA yjbN b4049 JW5950 yjbN dusA 38,468 cytosol [GO:0005829] cytosol [GO:0005829]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; tRNA binding [GO:0000049]; tRNA dihydrouridine synthase activity [GO:0017150]; tRNA-dihydrouridine20 synthase activity [GO:0102264] flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; tRNA binding [GO:0000049]; tRNA-dihydrouridine20 synthase activity [GO:0102264]; tRNA dihydrouridine synthase activity [GO:0017150] GO:0000049; GO:0005829; GO:0010181; GO:0017150; GO:0050660; GO:0102264 +P37313 DPPF_ECOLI Dipeptide transport ATP-binding protein DppF (EC 7.4.2.9) dppF dppE b3540 JW3509 dppE dppF 37,560 protein transport [GO:0015031]; response to radiation [GO:0009314] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; heme transmembrane transporter activity [GO:0015232]; protein transport [GO:0015031]; response to radiation [GO:0009314] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; heme transmembrane transporter activity [GO:0015232] GO:0005524; GO:0005886; GO:0009314; GO:0015031; GO:0015232; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P11454 ENTF_ECOLI Enterobactin synthase component F (EC 2.7.7.-) (Enterochelin synthase F) (Serine-activating enzyme) (Seryl-AMP ligase) entF b0586 JW0578 entF 141,991 amino acid activation for nonribosomal peptide biosynthetic process [GO:0043041]; enterobactin biosynthetic process [GO:0009239]; secondary metabolite biosynthetic process [GO:0044550] cytoplasm [GO:0005737]; cytosol [GO:0005829]; enterobactin synthetase complex [GO:0009366]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; cytosol [GO:0005829]; enterobactin synthetase complex [GO:0009366]; plasma membrane [GO:0005886]; 2,3-dihydroxybenzoate-serine ligase activity [GO:0047527]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; phosphopantetheine binding [GO:0031177]; amino acid activation for nonribosomal peptide biosynthetic process [GO:0043041]; enterobactin biosynthetic process [GO:0009239]; secondary metabolite biosynthetic process [GO:0044550] 2,3-dihydroxybenzoate-serine ligase activity [GO:0047527]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; phosphopantetheine binding [GO:0031177] GO:0005524; GO:0005737; GO:0005829; GO:0005886; GO:0009239; GO:0009366; GO:0016779; GO:0031177; GO:0043041; GO:0044550; GO:0047527 +P21177 FADB_ECOLI Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase (EC 4.2.1.17) (EC 5.1.2.3) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)] fadB oldB b3846 JW3822 oldB fadB 79,594 fatty acid beta-oxidation [GO:0006635] fatty acid beta-oxidation multienzyme complex [GO:0036125] fatty acid beta-oxidation multienzyme complex [GO:0036125]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; 3-hydroxybutyryl-CoA epimerase activity [GO:0008692]; dodecenoyl-CoA delta-isomerase activity [GO:0004165]; enoyl-CoA hydratase activity [GO:0004300]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; NAD+ binding [GO:0070403]; fatty acid beta-oxidation [GO:0006635] 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; 3-hydroxybutyryl-CoA epimerase activity [GO:0008692]; dodecenoyl-CoA delta-isomerase activity [GO:0004165]; enoyl-CoA hydratase activity [GO:0004300]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; NAD+ binding [GO:0070403] GO:0003857; GO:0004165; GO:0004300; GO:0006635; GO:0008692; GO:0016509; GO:0036125; GO:0070403 +P0ACL2 EXUR_ECOLI Exu regulon transcriptional regulator exuR b3094 JW3065 exuR 29,836 negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0045892 +P0AEL6 FEPB_ECOLI Ferrienterobactin-binding periplasmic protein fepB b0592 JW0584 fepB 34,283 cellular response to DNA damage stimulus [GO:0006974]; enterobactin transport [GO:0042930]; ferric-enterobactin import into cell [GO:0015685] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; cellular response to DNA damage stimulus [GO:0006974]; enterobactin transport [GO:0042930]; ferric-enterobactin import into cell [GO:0015685] GO:0006974; GO:0015685; GO:0030288; GO:0042930 SUBCELLULAR LOCATION: Periplasm. +P52614 FLIK_ECOLI Flagellar hook-length control protein fliK flaE flaR b1943 JW1927 flaE flaR fliK 39,312 bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973] bacterial-type flagellum hook [GO:0009424] bacterial-type flagellum hook [GO:0009424]; bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973] GO:0009424; GO:0044780; GO:0071973 +P0AEM4 FLGM_ECOLI Negative regulator of flagellin synthesis (Anti-sigma-28 factor) flgM b1071 JW1058 flgM 10,341 bacterial-type flagellum organization [GO:0044781]; negative regulation of proteolysis [GO:0045861] sigma factor antagonist activity [GO:0016989]; bacterial-type flagellum organization [GO:0044781]; negative regulation of proteolysis [GO:0045861] sigma factor antagonist activity [GO:0016989] GO:0016989; GO:0044781; GO:0045861 +P0ABY2 FLIT_ECOLI Flagellar protein FliT fliT b1926 JW1911 fliT 13,829 bacterial-type flagellum-dependent cell motility [GO:0071973]; bacterial-type flagellum organization [GO:0044781]; negative regulation of bacterial-type flagellum assembly [GO:1902209]; protein folding [GO:0006457] cytosol [GO:0005829] cytosol [GO:0005829]; bacterial-type flagellum organization [GO:0044781]; bacterial-type flagellum-dependent cell motility [GO:0071973]; negative regulation of bacterial-type flagellum assembly [GO:1902209]; protein folding [GO:0006457] GO:0005829; GO:0006457; GO:0044781; GO:0071973; GO:1902209 SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305}. +P23484 FECI_ECOLI Probable RNA polymerase sigma factor FecI fecI b4293 JW4253 fecI 19,480 DNA-templated transcription, initiation [GO:0006352]; ion transport [GO:0006811]; iron ion homeostasis [GO:0055072] DNA binding [GO:0003677]; sigma factor activity [GO:0016987]; DNA-templated transcription, initiation [GO:0006352]; ion transport [GO:0006811]; iron ion homeostasis [GO:0055072] DNA binding [GO:0003677]; sigma factor activity [GO:0016987] GO:0003677; GO:0006352; GO:0006811; GO:0016987; GO:0055072 +P0AEP3 GALU_ECOLI UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (Alpha-D-glucosyl-1-phosphate uridylyltransferase) (UDP-glucose pyrophosphorylase) (UDPGP) (Uridine diphosphoglucose pyrophosphorylase) galU ychD b1236 JW1224 ychD galU 32,942 colanic acid biosynthetic process [GO:0009242]; galactose catabolic process via UDP-galactose [GO:0033499]; lipopolysaccharide core region biosynthetic process [GO:0009244]; osmoregulated periplasmic glucan biosynthetic process [GO:1900727]; UDP-glucose metabolic process [GO:0006011] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; UTP:glucose-1-phosphate uridylyltransferase activity [GO:0003983]; colanic acid biosynthetic process [GO:0009242]; galactose catabolic process via UDP-galactose [GO:0033499]; lipopolysaccharide core region biosynthetic process [GO:0009244]; osmoregulated periplasmic glucan biosynthetic process [GO:1900727]; UDP-glucose metabolic process [GO:0006011] identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; UTP:glucose-1-phosphate uridylyltransferase activity [GO:0003983] GO:0000287; GO:0003983; GO:0005829; GO:0006011; GO:0009242; GO:0009244; GO:0032991; GO:0033499; GO:0042802; GO:1900727 +P45544 FRLR_ECOLI Probable fructoselysine utilization operon transcriptional repressor (HTH-type transcriptional regulator FrlR) frlR yhfR b3375 JW5698 yhfR frlR 27,821 negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0045892 +P60560 GUAC_ECOLI GMP reductase (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase) (Guanosine monophosphate reductase) guaC b0104 JW0101 guaC 37,384 purine ribonucleotide interconversion [GO:0015951] cytosol [GO:0005829]; GMP reductase complex [GO:1902560] cytosol [GO:0005829]; GMP reductase complex [GO:1902560]; GMP reductase activity [GO:0003920]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; purine ribonucleotide interconversion [GO:0015951] GMP reductase activity [GO:0003920]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] GO:0003920; GO:0005829; GO:0015951; GO:0042802; GO:0046872; GO:1902560 +P32674 GRE1_ECOLI Probable dehydratase PflD (EC 4.2.1.-) pflD yijL b3951 JW3923 yijL pflD 85,960 cytosol [GO:0005829] cytosol [GO:0005829]; lyase activity [GO:0016829] lyase activity [GO:0016829] GO:0005829; GO:0016829 +P0A7B8 HSLV_ECOLI ATP-dependent protease subunit HslV (EC 3.4.25.2) (Heat shock protein HslV) hslV htpO yiiC b3932 JW3903 htpO yiiC hslV 19,093 proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; response to heat [GO:0009408] cytosol [GO:0005829]; HslUV protease complex [GO:0009376]; proteasome core complex [GO:0005839] cytosol [GO:0005829]; HslUV protease complex [GO:0009376]; proteasome core complex [GO:0005839]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein domain specific binding [GO:0019904]; threonine-type endopeptidase activity [GO:0004298]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; response to heat [GO:0009408] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein domain specific binding [GO:0019904]; threonine-type endopeptidase activity [GO:0004298] GO:0000287; GO:0004298; GO:0005524; GO:0005829; GO:0005839; GO:0006508; GO:0009376; GO:0009408; GO:0019904; GO:0042802; GO:0051603 SUBCELLULAR LOCATION: Cytoplasm. +P64634 HOFN_ECOLI DNA utilization protein HofN hofN yrfC b3394 JW3357 yrfC hofN 20,796 carbon utilization [GO:0015976]; DNA catabolic process [GO:0006308]; type IV pilus biogenesis [GO:0043683]; type IV pilus-dependent motility [GO:0043107] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; carbon utilization [GO:0015976]; DNA catabolic process [GO:0006308]; type IV pilus biogenesis [GO:0043683]; type IV pilus-dependent motility [GO:0043107] GO:0005886; GO:0006308; GO:0015976; GO:0016021; GO:0043107; GO:0043683 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P06988 HISX_ECOLI Histidinol dehydrogenase (HDH) (EC 1.1.1.23) hisD b2020 JW2002 hisD 46,110 histidine biosynthetic process [GO:0000105] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; histidinol dehydrogenase activity [GO:0004399]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; zinc ion binding [GO:0008270]; histidine biosynthetic process [GO:0000105] histidinol dehydrogenase activity [GO:0004399]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; zinc ion binding [GO:0008270] GO:0000105; GO:0004399; GO:0005737; GO:0005829; GO:0008270; GO:0030145; GO:0046872; GO:0051287 +P0AB77 KBL_ECOLI 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (EC 2.3.1.29) (Glycine acetyltransferase) kbl b3617 JW3592 kbl 43,117 biosynthetic process [GO:0009058]; L-threonine catabolic process to glycine [GO:0019518] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glycine C-acetyltransferase activity [GO:0008890]; ligase activity [GO:0016874]; metal ion binding [GO:0046872]; pyridoxal phosphate binding [GO:0030170]; biosynthetic process [GO:0009058]; L-threonine catabolic process to glycine [GO:0019518] glycine C-acetyltransferase activity [GO:0008890]; ligase activity [GO:0016874]; metal ion binding [GO:0046872]; pyridoxal phosphate binding [GO:0030170] GO:0005737; GO:0005829; GO:0008890; GO:0009058; GO:0016874; GO:0019518; GO:0030170; GO:0046872 +P0ABJ1 CYOA_ECOLI Cytochrome bo(3) ubiquinol oxidase subunit 2 (Cytochrome b562-o complex subunit II) (Cytochrome o ubiquinol oxidase subunit 2) (Cytochrome o subunit 2) (Oxidase bo(3) subunit 2) (Ubiquinol oxidase chain B) (Ubiquinol oxidase polypeptide II) (Ubiquinol oxidase subunit 2) cyoA b0432 JW0422 cyoA 34,911 aerobic electron transport chain [GO:0019646]; aerobic respiration [GO:0009060]; ATP synthesis coupled electron transport [GO:0042773]; electron transport coupled proton transport [GO:0015990] cytochrome o ubiquinol oxidase complex [GO:0009319]; integral component of external side of plasma membrane [GO:0071575]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; respirasome [GO:0070469] cytochrome o ubiquinol oxidase complex [GO:0009319]; integral component of external side of plasma membrane [GO:0071575]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; respirasome [GO:0070469]; copper ion binding [GO:0005507]; cytochrome bo3 ubiquinol oxidase activity [GO:0009486]; cytochrome o ubiquinol oxidase activity [GO:0008827]; cytochrome-c oxidase activity [GO:0004129]; electron transfer activity [GO:0009055]; oxidoreduction-driven active transmembrane transporter activity [GO:0015453]; proton transmembrane transporter activity [GO:0015078]; aerobic electron transport chain [GO:0019646]; aerobic respiration [GO:0009060]; ATP synthesis coupled electron transport [GO:0042773]; electron transport coupled proton transport [GO:0015990] copper ion binding [GO:0005507]; cytochrome bo3 ubiquinol oxidase activity [GO:0009486]; cytochrome-c oxidase activity [GO:0004129]; cytochrome o ubiquinol oxidase activity [GO:0008827]; electron transfer activity [GO:0009055]; oxidoreduction-driven active transmembrane transporter activity [GO:0015453]; proton transmembrane transporter activity [GO:0015078] GO:0004129; GO:0005507; GO:0005886; GO:0005887; GO:0008827; GO:0009055; GO:0009060; GO:0009319; GO:0009486; GO:0015078; GO:0015453; GO:0015990; GO:0019646; GO:0042773; GO:0070469; GO:0071575 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:6365921}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:6365921}. +P0AD01 DCUR_ECOLI Transcriptional regulatory protein DcuR dcuR yjdG b4124 JW4085 yjdG dcuR 27,488 phosphorelay signal transduction system [GO:0000160]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; phosphorelay signal transduction system [GO:0000160]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156] GO:0000156; GO:0000160; GO:0001216; GO:0003677; GO:0005737; GO:0006351; GO:0045893 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A9D8 DAPD_ECOLI 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117) (Succinyl-CoA: tetrahydrodipicolinate N-succinyltransferase) (Tetrahydrodipicolinate N-succinyltransferase) (THDP succinyltransferase) (THP succinyltransferase) (Tetrahydropicolinate succinylase) dapD b0166 JW0161 dapD 29,892 diaminopimelate biosynthetic process [GO:0019877]; lysine biosynthetic process [GO:0009085]; lysine biosynthetic process via diaminopimelate [GO:0009089] cytosol [GO:0005829] cytosol [GO:0005829]; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity [GO:0008666]; nucleotidyltransferase activity [GO:0016779]; diaminopimelate biosynthetic process [GO:0019877]; lysine biosynthetic process [GO:0009085]; lysine biosynthetic process via diaminopimelate [GO:0009089] 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity [GO:0008666]; nucleotidyltransferase activity [GO:0016779] GO:0005829; GO:0008666; GO:0009085; GO:0009089; GO:0016779; GO:0019877 SUBCELLULAR LOCATION: Cytoplasm. +Q6BF17 DGOD_ECOLI D-galactonate dehydratase (GalD) (EC 4.2.1.6) dgoD yidU b4478 JW5629 yidU dgoD 42,523 cellular amino acid catabolic process [GO:0009063]; D-galactonate catabolic process [GO:0034194] galactonate dehydratase activity [GO:0008869]; magnesium ion binding [GO:0000287]; cellular amino acid catabolic process [GO:0009063]; D-galactonate catabolic process [GO:0034194] galactonate dehydratase activity [GO:0008869]; magnesium ion binding [GO:0000287] GO:0000287; GO:0008869; GO:0009063; GO:0034194 +P50465 END8_ECOLI Endonuclease 8 (DNA glycosylase/AP lyase Nei) (EC 3.2.2.-) (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase Nei) (Endonuclease VIII) nei b0714 JW0704 nei 29,845 base-excision repair [GO:0006284] class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]; zinc ion binding [GO:0008270]; base-excision repair [GO:0006284] class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [GO:0000703]; zinc ion binding [GO:0008270] GO:0000703; GO:0003684; GO:0003906; GO:0006284; GO:0008270; GO:0140078 +P76552 EUTH_ECOLI Probable ethanolamine permease EutH (Ethanolamine utilization protein EutH) eutH yffU b2452 JW2436 yffU eutH 42,807 ethanolamine catabolic process [GO:0046336] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ethanolamine transmembrane transporter activity [GO:0034228]; ethanolamine catabolic process [GO:0046336] ethanolamine transmembrane transporter activity [GO:0034228] GO:0005886; GO:0016021; GO:0034228; GO:0046336 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P30855 EVGS_ECOLI Sensor protein EvgS (EC 2.7.13.3) evgS b2370 JW2367 evgS 134,743 phosphorelay signal transduction system [GO:0000160]; protein autophosphorylation [GO:0046777]; response to acidic pH [GO:0010447] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155]; phosphorelay signal transduction system [GO:0000160]; protein autophosphorylation [GO:0046777]; response to acidic pH [GO:0010447] ATP binding [GO:0005524]; phosphorelay sensor kinase activity [GO:0000155] GO:0000155; GO:0000160; GO:0005524; GO:0005886; GO:0010447; GO:0016021; GO:0046777 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0ACZ2 ETP_ECOLI Low molecular weight protein-tyrosine-phosphatase Etp (EC 3.1.3.48) etp yccY b0982 JW5132 yccY etp 16,386 peptidyl-tyrosine dephosphorylation [GO:0035335] protein tyrosine phosphatase activity [GO:0004725]; peptidyl-tyrosine dephosphorylation [GO:0035335] protein tyrosine phosphatase activity [GO:0004725] GO:0004725; GO:0035335 +P0A8G9 EX7S_ECOLI Exodeoxyribonuclease 7 small subunit (EC 3.1.11.6) (Exodeoxyribonuclease VII small subunit) (Exonuclease VII small subunit) xseB yajE b0422 JW0412 yajE xseB 8,952 DNA catabolic process [GO:0006308] cytosol [GO:0005829]; exodeoxyribonuclease VII complex [GO:0009318] cytosol [GO:0005829]; exodeoxyribonuclease VII complex [GO:0009318]; exodeoxyribonuclease VII activity [GO:0008855]; DNA catabolic process [GO:0006308] exodeoxyribonuclease VII activity [GO:0008855] GO:0005829; GO:0006308; GO:0008855; GO:0009318 SUBCELLULAR LOCATION: Cytoplasm. +P39405 FHUF_ECOLI Ferric iron reductase protein FhuF fhuF yjjS b4367 JW4331 yjjS fhuF 30,113 reductive iron assimilation [GO:0033215]; siderophore-dependent iron import into cell [GO:0033214] cytosol [GO:0005829]; plasma membrane [GO:0005886] cytosol [GO:0005829]; plasma membrane [GO:0005886]; 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; reductive iron assimilation [GO:0033215]; siderophore-dependent iron import into cell [GO:0033214] 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872] GO:0005829; GO:0005886; GO:0033214; GO:0033215; GO:0046872; GO:0051537 SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein. +Q47208 FDRA_ECOLI Protein FdrA fdrA ylbD b0518 JW0506 ylbD fdrA 58,596 bacterial-type flagellum-dependent cell motility [GO:0071973]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; succinate-CoA ligase complex (ADP-forming) [GO:0009361] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; succinate-CoA ligase complex (ADP-forming) [GO:0009361]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]; succinate-CoA ligase (GDP-forming) activity [GO:0004776]; bacterial-type flagellum-dependent cell motility [GO:0071973]; tricarboxylic acid cycle [GO:0006099] succinate-CoA ligase (ADP-forming) activity [GO:0004775]; succinate-CoA ligase (GDP-forming) activity [GO:0004776] GO:0004775; GO:0004776; GO:0005829; GO:0005886; GO:0006099; GO:0009361; GO:0016021; GO:0071973 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P15031 FECE_ECOLI Fe(3+) dicitrate transport ATP-binding protein FecE (Iron(III) dicitrate transport ATP-binding protein FecE) fecE b4287 JW4247 fecE 28,191 ion transport [GO:0006811]; iron ion homeostasis [GO:0055072] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ion transport [GO:0006811]; iron ion homeostasis [GO:0055072] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0006811; GO:0042626; GO:0055072 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. +P32669 FSAB_ECOLI Fructose-6-phosphate aldolase 2 (EC 4.1.2.-) (Fructose-6-phosphate aldolase B) (FSAB) fsaB talC yijG b3946 JW3918 talC yijG fsaB 23,555 fructose metabolic process [GO:0006000] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; fructose 6-phosphate aldolase activity [GO:0097023]; fructose metabolic process [GO:0006000] fructose 6-phosphate aldolase activity [GO:0097023] GO:0005737; GO:0006000; GO:0097023 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P03024 GALR_ECOLI HTH-type transcriptional regulator GalR (Galactose operon repressor) galR b2837 JW2805 galR 37,094 galactose metabolic process [GO:0006012]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; galactose metabolic process [GO:0006012]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003677; GO:0003700; GO:0006012; GO:0006351; GO:0006355; GO:0042802 +P14407 FUMB_ECOLI Fumarate hydratase class I, anaerobic (EC 4.2.1.2) (D-tartrate dehydratase) (EC 4.2.1.81) (Fumarase B) fumB b4122 JW4083 fumB 60,105 cellular response to DNA damage stimulus [GO:0006974]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; D(-)-tartrate dehydratase activity [GO:0047808]; fumarate hydratase activity [GO:0004333]; metal ion binding [GO:0046872]; cellular response to DNA damage stimulus [GO:0006974]; tricarboxylic acid cycle [GO:0006099] 4 iron, 4 sulfur cluster binding [GO:0051539]; D(-)-tartrate dehydratase activity [GO:0047808]; fumarate hydratase activity [GO:0004333]; metal ion binding [GO:0046872] GO:0004333; GO:0005829; GO:0006099; GO:0006974; GO:0046872; GO:0047808; GO:0051539 +P32662 GPH_ECOLI Phosphoglycolate phosphatase (PGP) (PGPase) (EC 3.1.3.18) gph yhfE b3385 JW3348 yhfE gph 27,389 carbohydrate metabolic process [GO:0005975]; dephosphorylation [GO:0016311]; DNA repair [GO:0006281]; glycolate biosynthetic process [GO:0046295] cytosol [GO:0005829] cytosol [GO:0005829]; chloride ion binding [GO:0031404]; magnesium ion binding [GO:0000287]; phosphoglycolate phosphatase activity [GO:0008967]; carbohydrate metabolic process [GO:0005975]; dephosphorylation [GO:0016311]; DNA repair [GO:0006281]; glycolate biosynthetic process [GO:0046295] chloride ion binding [GO:0031404]; magnesium ion binding [GO:0000287]; phosphoglycolate phosphatase activity [GO:0008967] GO:0000287; GO:0005829; GO:0005975; GO:0006281; GO:0008967; GO:0016311; GO:0031404; GO:0046295 +P25519 HFLX_ECOLI GTPase HflX (GTP-binding protein HflX) hflX b4173 JW4131 hflX 48,327 peptidyl-serine autophosphorylation [GO:0036289]; rescue of stalled ribosome [GO:0072344]; response to heat [GO:0009408]; ribosome disassembly [GO:0032790] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanosine tetraphosphate binding [GO:0097216]; metal ion binding [GO:0046872]; ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843]; peptidyl-serine autophosphorylation [GO:0036289]; rescue of stalled ribosome [GO:0072344]; response to heat [GO:0009408]; ribosome disassembly [GO:0032790] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; guanosine tetraphosphate binding [GO:0097216]; metal ion binding [GO:0046872]; ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843] GO:0003924; GO:0005524; GO:0005525; GO:0005737; GO:0005829; GO:0009408; GO:0016887; GO:0019843; GO:0032790; GO:0036289; GO:0043022; GO:0043023; GO:0046872; GO:0072344; GO:0097216 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00900, ECO:0000269|PubMed:19181811}. Note=May associate with membranes. +Q47154 LAFU_ECOLI Putative truncated flagellar export/assembly protein LafU lafU mbhA b0230 JW5812 mbhA lafU 23,779 +P0AAE5 ARCD_ECOLI Putative arginine/ornithine antiporter ydgI b1605 JW1597 ydgI 49,501 amino acid transport [GO:0006865] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; antiporter activity [GO:0015297]; amino acid transport [GO:0006865] antiporter activity [GO:0015297] GO:0005887; GO:0006865; GO:0015297 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P36659 CBPA_ECOLI Curved DNA-binding protein cbpA b1000 JW0985 cbpA 34,455 chaperone cofactor-dependent protein refolding [GO:0051085]; protein refolding [GO:0042026] cytoplasm [GO:0005737]; nucleoid [GO:0009295] cytoplasm [GO:0005737]; nucleoid [GO:0009295]; bent DNA binding [GO:0003681]; unfolded protein binding [GO:0051082]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein refolding [GO:0042026] bent DNA binding [GO:0003681]; unfolded protein binding [GO:0051082] GO:0003681; GO:0005737; GO:0009295; GO:0042026; GO:0051082; GO:0051085 SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000269|PubMed:10947847, ECO:0000269|PubMed:8302830}. +P0AE60 CEDA_ECOLI Cell division activator CedA cedA ydjP b1731 JW1720 ydjP cedA 9,377 cell cycle [GO:0007049]; cell division [GO:0051301]; regulation of cell division [GO:0051302] double-stranded DNA binding [GO:0003690]; cell cycle [GO:0007049]; cell division [GO:0051301]; regulation of cell division [GO:0051302] double-stranded DNA binding [GO:0003690] GO:0003690; GO:0007049; GO:0051301; GO:0051302 +P0ABI4 CORA_ECOLI Magnesium transport protein CorA corA b3816 JW3789 corA 36,590 cobalt ion transport [GO:0006824]; magnesium ion transport [GO:0015693]; nickel cation transmembrane transport [GO:0035444] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cobalt ion transmembrane transporter activity [GO:0015087]; magnesium ion transmembrane transporter activity [GO:0015095]; nickel cation transmembrane transporter activity [GO:0015099]; cobalt ion transport [GO:0006824]; magnesium ion transport [GO:0015693]; nickel cation transmembrane transport [GO:0035444] cobalt ion transmembrane transporter activity [GO:0015087]; magnesium ion transmembrane transporter activity [GO:0015095]; nickel cation transmembrane transporter activity [GO:0015099] GO:0005886; GO:0006824; GO:0015087; GO:0015095; GO:0015099; GO:0015693; GO:0016021; GO:0035444 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:780341}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9WZ31}. +P0ABJ9 CYDA_ECOLI Cytochrome bd-I ubiquinol oxidase subunit 1 (EC 7.1.1.7) (Cytochrome bd-I oxidase subunit I) (Cytochrome d ubiquinol oxidase subunit I) cydA cyd-1 b0733 JW0722 cyd-1 cydA 58,205 aerobic electron transport chain [GO:0019646]; oxidative phosphorylation [GO:0006119] cytochrome complex [GO:0070069]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] cytochrome complex [GO:0070069]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on diphenols and related substances as donors [GO:0016679]; oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [GO:0016682]; aerobic electron transport chain [GO:0019646]; oxidative phosphorylation [GO:0006119] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on diphenols and related substances as donors [GO:0016679]; oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [GO:0016682] GO:0005886; GO:0005887; GO:0006119; GO:0009055; GO:0016020; GO:0016679; GO:0016682; GO:0019646; GO:0020037; GO:0046872; GO:0070069 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15013751, ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:15013751, ECO:0000269|PubMed:16079137}. +P0AAE0 CYCA_ECOLI D-serine/D-alanine/glycine transporter cycA dagA ytfD b4208 JW4166 dagA ytfD cycA 51,660 beta-alanine transport [GO:0001762]; D-alanine transport [GO:0042941]; D-serine transport [GO:0042942]; glycine transport [GO:0015816]; L-alanine transport [GO:0015808] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; beta-alanine transmembrane transporter activity [GO:0001761]; D-alanine transmembrane transporter activity [GO:0042944]; D-serine transmembrane transporter activity [GO:0042945]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; beta-alanine transport [GO:0001762]; D-alanine transport [GO:0042941]; D-serine transport [GO:0042942]; glycine transport [GO:0015816]; L-alanine transport [GO:0015808] beta-alanine transmembrane transporter activity [GO:0001761]; D-alanine transmembrane transporter activity [GO:0042944]; D-serine transmembrane transporter activity [GO:0042945]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180] GO:0001761; GO:0001762; GO:0005886; GO:0005887; GO:0015180; GO:0015187; GO:0015808; GO:0015816; GO:0042941; GO:0042942; GO:0042944; GO:0042945 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein. +P17854 CYSH_ECOLI Phosphoadenosine 5'-phosphosulfate reductase (PAPS reductase) (EC 1.8.4.8) (3'-phosphoadenylylsulfate reductase) (PAPS reductase, thioredoxin dependent) (PAPS sulfotransferase) (PAdoPS reductase) cysH b2762 JW2732 cysH 27,976 hydrogen sulfide biosynthetic process [GO:0070814]; sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [GO:0019379]; sulfur compound metabolic process [GO:0006790] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; phosphoadenylyl-sulfate reductase (thioredoxin) activity [GO:0004604]; hydrogen sulfide biosynthetic process [GO:0070814]; sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [GO:0019379]; sulfur compound metabolic process [GO:0006790] phosphoadenylyl-sulfate reductase (thioredoxin) activity [GO:0004604] GO:0004604; GO:0005737; GO:0006790; GO:0019379; GO:0070814 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00063, ECO:0000305}. +P28303 DINF_ECOLI DNA damage-inducible protein F dinF b4044 JW4004 dinF 49,646 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297]; xenobiotic transmembrane transporter activity [GO:0042910] antiporter activity [GO:0015297]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0015297; GO:0016021; GO:0042910 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P56262 DLHH_ECOLI Putative carboxymethylenebutenolidase (EC 3.1.1.45) (Dienelactone hydrolase) (DLH) ysgA b3830 JW5853 ysgA 29,425 carboxymethylenebutenolidase activity [GO:0008806] carboxymethylenebutenolidase activity [GO:0008806] GO:0008806 +P38097 DGCE_ECOLI Probable diguanylate cyclase DgcE (DGC) (EC 2.7.7.65) dgcE yegE b2067 JW2052 yegE dgcE 123,887 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872] diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872] GO:0005525; GO:0005886; GO:0016021; GO:0046872; GO:0052621 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P06846 EBGR_ECOLI HTH-type transcriptional regulator EbgR (Ebg operon repressor) ebgR b3075 JW3046 ebgR 36,210 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355; GO:0045892 +P76014 DHAL_ECOLI PEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL (EC 2.7.1.121) dhaL ycgS b1199 JW5186 ycgS dhaL 22,632 glycerol catabolic process [GO:0019563] cytosol [GO:0005829] cytosol [GO:0005829]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; glycerone kinase activity [GO:0004371]; magnesium ion binding [GO:0000287]; phosphoenolpyruvate-glycerone phosphotransferase activity [GO:0047324]; glycerol catabolic process [GO:0019563] ADP binding [GO:0043531]; ATP binding [GO:0005524]; glycerone kinase activity [GO:0004371]; magnesium ion binding [GO:0000287]; phosphoenolpyruvate-glycerone phosphotransferase activity [GO:0047324] GO:0000287; GO:0004371; GO:0005524; GO:0005829; GO:0019563; GO:0043531; GO:0047324 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P76551 EUTA_ECOLI Ethanolamine ammonia-lyase reactivase EutA eutA yffT b2451 JW2435 yffT eutA 49,599 ethanolamine catabolic process [GO:0046336]; positive regulation of lyase activity [GO:0051349]; protein repair [GO:0030091] ethanolamine catabolic process [GO:0046336]; positive regulation of lyase activity [GO:0051349]; protein repair [GO:0030091] GO:0030091; GO:0046336; GO:0051349 SUBCELLULAR LOCATION: Bacterial microcompartment {ECO:0000305}. +P0A953 FABB_ECOLI 3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC 2.3.1.41) (3-oxoacyl-[acyl-carrier-protein] synthase I) (Beta-ketoacyl-ACP synthase I) (KAS I) fabB fabC b2323 JW2320 fabC fabB 42,613 fatty acid biosynthetic process [GO:0006633]; lipid biosynthetic process [GO:0008610] cytosol [GO:0005829] cytosol [GO:0005829]; 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; fatty acid biosynthetic process [GO:0006633]; lipid biosynthetic process [GO:0008610] 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315] GO:0004315; GO:0005829; GO:0006633; GO:0008610 SUBCELLULAR LOCATION: Cytoplasm. +P04335 FRSA_ECOLI Esterase FrsA (EC 3.1.1.1) (Fermentation/respiration switch protein) frsA yafA b0239 JW0229 yafA frsA 47,009 regulation of carbohydrate catabolic process [GO:0043470] hydrolase activity [GO:0016787]; methyl indole-3-acetate esterase activity [GO:0080030]; regulation of carbohydrate catabolic process [GO:0043470] hydrolase activity [GO:0016787]; methyl indole-3-acetate esterase activity [GO:0080030] GO:0016787; GO:0043470; GO:0080030 +P26648 FTSP_ECOLI Cell division protein FtsP ftsP sufI b3017 JW2985 sufI ftsP 51,858 cell division [GO:0051301]; FtsZ-dependent cytokinesis [GO:0043093]; response to ionizing radiation [GO:0010212]; response to oxidative stress [GO:0006979] cell division site [GO:0032153]; outer membrane-bounded periplasmic space [GO:0030288] cell division site [GO:0032153]; outer membrane-bounded periplasmic space [GO:0030288]; copper ion binding [GO:0005507]; oxidoreductase activity [GO:0016491]; cell division [GO:0051301]; FtsZ-dependent cytokinesis [GO:0043093]; response to ionizing radiation [GO:0010212]; response to oxidative stress [GO:0006979] copper ion binding [GO:0005507]; oxidoreductase activity [GO:0016491] GO:0005507; GO:0006979; GO:0010212; GO:0016491; GO:0030288; GO:0032153; GO:0043093; GO:0051301 SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00915, ECO:0000269|PubMed:10593889, ECO:0000269|PubMed:19135451}. Note=Localizes to the division septum. Localization requires FtsZ, FtsQ, FtsL and FtsN. +P09831 GLTB_ECOLI Glutamate synthase [NADPH] large chain (EC 1.4.1.13) (Glutamate synthase subunit alpha) (GLTS alpha chain) (NADPH-GOGAT) gltB aspB b3212 JW3179 aspB gltB 163,297 ammonia assimilation cycle [GO:0019676]; glutamate biosynthetic process [GO:0006537]; L-glutamate biosynthetic process [GO:0097054] cytosol [GO:0005829] cytosol [GO:0005829]; 3 iron, 4 sulfur cluster binding [GO:0051538]; glutamate synthase (NADPH) activity [GO:0004355]; glutamate synthase activity [GO:0015930]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; ammonia assimilation cycle [GO:0019676]; glutamate biosynthetic process [GO:0006537]; L-glutamate biosynthetic process [GO:0097054] 3 iron, 4 sulfur cluster binding [GO:0051538]; glutamate synthase (NADPH) activity [GO:0004355]; glutamate synthase activity [GO:0015930]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] GO:0004355; GO:0005829; GO:0006537; GO:0015930; GO:0016491; GO:0019676; GO:0046872; GO:0051538; GO:0097054 +P09394 GLPQ_ECOLI Glycerophosphodiester phosphodiesterase, periplasmic (Glycerophosphoryl diester phosphodiesterase, periplasmic) (EC 3.1.4.46) glpQ b2239 JW2233 glpQ 40,843 glycerol metabolic process [GO:0006071]; lipid metabolic process [GO:0006629] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; calcium ion binding [GO:0005509]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; metal ion binding [GO:0046872]; glycerol metabolic process [GO:0006071]; lipid metabolic process [GO:0006629] calcium ion binding [GO:0005509]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; metal ion binding [GO:0046872] GO:0005509; GO:0006071; GO:0006629; GO:0008889; GO:0042597; GO:0046872 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:2829735}. +P32131 HEMN_ECOLI Oxygen-independent coproporphyrinogen III oxidase (CPO) (EC 1.3.98.3) (Coproporphyrinogen III dehydrogenase) (CPDH) hemN yihJ b3867 JW3838 yihJ hemN 52,729 porphyrin-containing compound biosynthetic process [GO:0006779]; protoporphyrinogen IX biosynthetic process [GO:0006782] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 4 iron, 4 sulfur cluster binding [GO:0051539]; coproporphyrinogen dehydrogenase activity [GO:0051989]; coproporphyrinogen oxidase activity [GO:0004109]; metal ion binding [GO:0046872]; porphyrin-containing compound biosynthetic process [GO:0006779]; protoporphyrinogen IX biosynthetic process [GO:0006782] 4 iron, 4 sulfur cluster binding [GO:0051539]; coproporphyrinogen dehydrogenase activity [GO:0051989]; coproporphyrinogen oxidase activity [GO:0004109]; metal ion binding [GO:0046872] GO:0004109; GO:0005737; GO:0006779; GO:0006782; GO:0046872; GO:0051539; GO:0051989 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12114526}. +P42593 FADH_ECOLI 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing] (DCR) (EC 1.3.1.34) (2,4-dienoyl-coenzyme A reductase [NADPH]) fadH ygjL b3081 JW3052 ygjL fadH 72,678 fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway [GO:0033543] 2,4-dienoyl-CoA reductase (NADPH) activity [GO:0008670]; 4 iron, 4 sulfur cluster binding [GO:0051539]; FAD binding [GO:0071949]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway [GO:0033543] 2,4-dienoyl-CoA reductase (NADPH) activity [GO:0008670]; 4 iron, 4 sulfur cluster binding [GO:0051539]; FAD binding [GO:0071949]; FMN binding [GO:0010181]; metal ion binding [GO:0046872] GO:0008670; GO:0010181; GO:0033543; GO:0046872; GO:0051539; GO:0071949 +P0AAI9 FABD_ECOLI Malonyl CoA-acyl carrier protein transacylase (MCT) (EC 2.3.1.39) fabD tfpA b1092 JW1078 tfpA fabD 32,417 fatty acid biosynthetic process [GO:0006633] cytosol [GO:0005829] cytosol [GO:0005829]; [acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; fatty acid biosynthetic process [GO:0006633] [acyl-carrier-protein] S-malonyltransferase activity [GO:0004314] GO:0004314; GO:0005829; GO:0006633 +P76938 EPMC_ECOLI Elongation factor P hydroxylase (EF-P hydroxylase) (EC 1.14.-.-) (EF-P post-translational modification enzyme C) epmC yfcM b2326 JW5381 yfcM epmC 21,146 peptidyl-lysine hydroxylation involved in bacterial-type EF-P lysine modification [GO:1901260]; post-translational protein modification [GO:0043687] metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; peptidyl-lysine hydroxylation involved in bacterial-type EF-P lysine modification [GO:1901260]; post-translational protein modification [GO:0043687] metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709] GO:0004497; GO:0016709; GO:0043687; GO:0046872; GO:1901260 +P0A8N7 EPMA_ECOLI Elongation factor P--(R)-beta-lysine ligase (EF-P--(R)-beta-lysine ligase) (EC 6.3.1.-) (EF-P post-translational modification enzyme A) (EF-P-lysine lysyltransferase) (GX) epmA genX poxA yjeA b4155 JW4116 genX poxA yjeA epmA 36,976 lysyl-tRNA aminoacylation [GO:0006430]; protein-lysine lysylation [GO:0071915]; protein-N6-(L-lysyl)-L-lysine modification to protein-N6-(beta-lysyl)-L-lysine [GO:0072581] cytosol [GO:0005829] cytosol [GO:0005829]; acid-ammonia (or amide) ligase activity [GO:0016880]; ATP binding [GO:0005524]; lysine-tRNA ligase activity [GO:0004824]; protein-lysine lysyltransferase activity [GO:0052868]; tRNA binding [GO:0000049]; lysyl-tRNA aminoacylation [GO:0006430]; protein-lysine lysylation [GO:0071915]; protein-N6-(L-lysyl)-L-lysine modification to protein-N6-(beta-lysyl)-L-lysine [GO:0072581] acid-ammonia (or amide) ligase activity [GO:0016880]; ATP binding [GO:0005524]; lysine-tRNA ligase activity [GO:0004824]; protein-lysine lysyltransferase activity [GO:0052868]; tRNA binding [GO:0000049] GO:0000049; GO:0004824; GO:0005524; GO:0005829; GO:0006430; GO:0016880; GO:0052868; GO:0071915; GO:0072581 +P30845 EPTA_ECOLI Phosphoethanolamine transferase EptA (EC 2.7.-.-) (Polymyxin resistance protein PmrC) eptA pmrC yjdB b4114 JW5730 pmrC yjdB eptA 61,667 lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; lipopolysaccharide core region biosynthetic process [GO:0009244]; response to antibiotic [GO:0046677] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; phosphotransferase activity, phosphate group as acceptor [GO:0016776]; sulfuric ester hydrolase activity [GO:0008484]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103]; lipopolysaccharide core region biosynthetic process [GO:0009244]; response to antibiotic [GO:0046677] phosphotransferase activity, phosphate group as acceptor [GO:0016776]; sulfuric ester hydrolase activity [GO:0008484] GO:0005886; GO:0008484; GO:0009103; GO:0009244; GO:0009245; GO:0016021; GO:0016776; GO:0046677 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137}. +P0ABY4 FLAW_ECOLI Flavodoxin 2 fldB b2895 JW2863 fldB 19,700 electron transfer activity [GO:0009055]; FMN binding [GO:0010181] electron transfer activity [GO:0009055]; FMN binding [GO:0010181] GO:0009055; GO:0010181 +P75933 FLGA_ECOLI Flagella basal body P-ring formation protein FlgA flgA b1072 JW1059 flgA 23,519 bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973] GO:0042597; GO:0044780; GO:0071973 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P26266 FEPE_ECOLI Ferric enterobactin transport protein FepE fepE b0587 JW0579 fepE 42,100 ferric-enterobactin import into cell [GO:0015685]; lipopolysaccharide biosynthetic process [GO:0009103] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ferric-enterobactin transmembrane transporter activity [GO:0015620]; protein tyrosine kinase activity [GO:0004713]; ferric-enterobactin import into cell [GO:0015685]; lipopolysaccharide biosynthetic process [GO:0009103] ferric-enterobactin transmembrane transporter activity [GO:0015620]; protein tyrosine kinase activity [GO:0004713] GO:0004713; GO:0005886; GO:0009103; GO:0015620; GO:0015685; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P23882 FMT_ECOLI Methionyl-tRNA formyltransferase (EC 2.1.2.9) (Met-tRNA(fMet) formyltransferase) fmt yhdD b3288 JW3249 yhdD fmt 34,168 charged-tRNA amino acid modification [GO:0019988]; conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [GO:0071951] cytosol [GO:0005829] cytosol [GO:0005829]; methionyl-tRNA formyltransferase activity [GO:0004479]; charged-tRNA amino acid modification [GO:0019988]; conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [GO:0071951] methionyl-tRNA formyltransferase activity [GO:0004479] GO:0004479; GO:0005829; GO:0019988; GO:0071951 +P0ABW9 FLGB_ECOLI Flagellar basal body rod protein FlgB (Putative proximal rod protein) flgB fla FII flbA b1073 JW1060 fla FII flbA flgB 15,240 bacterial-type flagellum-dependent swarming motility [GO:0071978] bacterial-type flagellum basal body, rod [GO:0030694]; bacterial-type flagellum hook [GO:0009424] bacterial-type flagellum basal body, rod [GO:0030694]; bacterial-type flagellum hook [GO:0009424]; bacterial-type flagellum-dependent swarming motility [GO:0071978] GO:0009424; GO:0030694; GO:0071978 SUBCELLULAR LOCATION: Bacterial flagellum basal body {ECO:0000250}. +P0AAJ5 FDOH_ECOLI Formate dehydrogenase-O iron-sulfur subunit (Aerobic formate dehydrogenase iron-sulfur subunit) (FDH-Z subunit beta) (Formate dehydrogenase-O subunit beta) fdoH b3893 JW3864 fdoH 33,100 cellular respiration [GO:0045333]; formate oxidation [GO:0015944] formate dehydrogenase complex [GO:0009326]; integral component of membrane [GO:0016021]; intrinsic component of the cytoplasmic side of the plasma membrane [GO:0031235]; membrane [GO:0016020] formate dehydrogenase complex [GO:0009326]; integral component of membrane [GO:0016021]; intrinsic component of the cytoplasmic side of the plasma membrane [GO:0031235]; membrane [GO:0016020]; 4 iron, 4 sulfur cluster binding [GO:0051539]; formate dehydrogenase (quinone) activity [GO:0036397]; metal ion binding [GO:0046872]; cellular respiration [GO:0045333]; formate oxidation [GO:0015944] 4 iron, 4 sulfur cluster binding [GO:0051539]; formate dehydrogenase (quinone) activity [GO:0036397]; metal ion binding [GO:0046872] GO:0009326; GO:0015944; GO:0016020; GO:0016021; GO:0031235; GO:0036397; GO:0045333; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein. +P32176 FDOG_ECOLI Formate dehydrogenase-O major subunit (EC 1.17.1.9) (Aerobic formate dehydrogenase major subunit) (FDH-Z subunit alpha) (Formate dehydrogenase-O subunit alpha) fdoG b3894 JW3865 fdoG 112,549 anaerobic respiration [GO:0009061]; cellular respiration [GO:0045333]; cellular response to DNA damage stimulus [GO:0006974]; formate oxidation [GO:0015944] cytosol [GO:0005829]; formate dehydrogenase complex [GO:0009326]; membrane [GO:0016020]; periplasmic space [GO:0042597] cytosol [GO:0005829]; formate dehydrogenase complex [GO:0009326]; membrane [GO:0016020]; periplasmic space [GO:0042597]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; formate dehydrogenase (cytochrome-c-553) activity [GO:0047111]; formate dehydrogenase (NAD+) activity [GO:0008863]; formate dehydrogenase (quinone) activity [GO:0036397]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; anaerobic respiration [GO:0009061]; cellular respiration [GO:0045333]; cellular response to DNA damage stimulus [GO:0006974]; formate oxidation [GO:0015944] 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; formate dehydrogenase (cytochrome-c-553) activity [GO:0047111]; formate dehydrogenase (NAD+) activity [GO:0008863]; formate dehydrogenase (quinone) activity [GO:0036397]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546] GO:0005829; GO:0006974; GO:0008863; GO:0009055; GO:0009061; GO:0009326; GO:0015944; GO:0016020; GO:0030151; GO:0036397; GO:0042597; GO:0043546; GO:0045333; GO:0047111; GO:0051539 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P0ADH5 FIMB_ECOLI Type 1 fimbriae regulatory protein FimB fimB b4312 JW4275 fimB 22,993 cellular response to DNA damage stimulus [GO:0006974]; DNA integration [GO:0015074]; DNA recombination [GO:0006310] DNA binding [GO:0003677]; cellular response to DNA damage stimulus [GO:0006974]; DNA integration [GO:0015074]; DNA recombination [GO:0006310] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0006974; GO:0015074 +P0AEN8 FUCM_ECOLI L-fucose mutarotase (EC 5.1.3.29) (D-ribose pyranase) (EC 5.4.99.62) (Fucose 1-epimerase) (Type-2 mutarotase) fucU b2804 JW2775 fucU 15,473 fucose metabolic process [GO:0006004]; fucosylation [GO:0036065]; L-fucose metabolic process [GO:0042354] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; D-ribose pyranase activity [GO:0062193]; fucose binding [GO:0042806]; L-fucose mutarotase activity [GO:0036373]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]; fucose metabolic process [GO:0006004]; fucosylation [GO:0036065]; L-fucose metabolic process [GO:0042354] D-ribose pyranase activity [GO:0062193]; fucose binding [GO:0042806]; L-fucose mutarotase activity [GO:0036373]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857] GO:0005737; GO:0006004; GO:0016857; GO:0036065; GO:0036373; GO:0042354; GO:0042806; GO:0062193 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A9S1 FUCO_ECOLI Lactaldehyde reductase (EC 1.1.1.77) (Propanediol oxidoreductase) fucO b2799 JW2770 fucO 40,513 glycol catabolic process [GO:0042846]; L-fucose catabolic process [GO:0042355]; propanediol metabolic process [GO:0051143]; rhamnose catabolic process [GO:0019301] cytosol [GO:0005829] cytosol [GO:0005829]; alcohol dehydrogenase (NAD+) activity [GO:0004022]; ferrous iron binding [GO:0008198]; lactaldehyde reductase activity [GO:0008912]; R-lactaldehyde reductase activity [GO:0052660]; S-lactaldehyde reductase activity [GO:0052661]; glycol catabolic process [GO:0042846]; L-fucose catabolic process [GO:0042355]; propanediol metabolic process [GO:0051143]; rhamnose catabolic process [GO:0019301] alcohol dehydrogenase (NAD+) activity [GO:0004022]; ferrous iron binding [GO:0008198]; lactaldehyde reductase activity [GO:0008912]; R-lactaldehyde reductase activity [GO:0052660]; S-lactaldehyde reductase activity [GO:0052661] GO:0004022; GO:0005829; GO:0008198; GO:0008912; GO:0019301; GO:0042355; GO:0042846; GO:0051143; GO:0052660; GO:0052661 +P0AAB6 GALF_ECOLI UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (Alpha-D-glucosyl-1-phosphate uridylyltransferase) (UDP-glucose pyrophosphorylase) (UDPGP) (Uridine diphosphoglucose pyrophosphorylase) galF wcaN b2042 JW2027 wcaN galF 32,829 lipopolysaccharide biosynthetic process [GO:0009103]; UDP-glucose metabolic process [GO:0006011] cytosol [GO:0005829] cytosol [GO:0005829]; enzyme regulator activity [GO:0030234]; UTP:glucose-1-phosphate uridylyltransferase activity [GO:0003983]; lipopolysaccharide biosynthetic process [GO:0009103]; UDP-glucose metabolic process [GO:0006011] enzyme regulator activity [GO:0030234]; UTP:glucose-1-phosphate uridylyltransferase activity [GO:0003983] GO:0003983; GO:0005829; GO:0006011; GO:0009103; GO:0030234 +P52073 GLCE_ECOLI Glycolate oxidase subunit GlcE (EC 1.1.99.14) (Glycolate dehydrogenase subunit GlcE) glcE gox yghL b4468 JW5487 gox yghL glcE 38,361 glycolate catabolic process [GO:0046296]; lactate catabolic process [GO:1903457] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; D-2-hydroxy-acid dehydrogenase activity [GO:0047809]; D-lactate dehydrogenase (cytochrome) activity [GO:0004458]; D-lactate dehydrogenase activity [GO:0008720]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; glycolate dehydrogenase activity [GO:0019154]; glycolate catabolic process [GO:0046296]; lactate catabolic process [GO:1903457] D-2-hydroxy-acid dehydrogenase activity [GO:0047809]; D-lactate dehydrogenase (cytochrome) activity [GO:0004458]; D-lactate dehydrogenase activity [GO:0008720]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; glycolate dehydrogenase activity [GO:0019154] GO:0004458; GO:0005886; GO:0008720; GO:0019154; GO:0046296; GO:0047809; GO:0050660; GO:0071949; GO:1903457 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:2689218}. Note=Glycolate oxidoreductase activity was shown to be firmly associated with the cytoplasmic membranes. {ECO:0000269|PubMed:2689218}. +P30147 HYI_ECOLI Hydroxypyruvate isomerase (EC 5.3.1.22) (Glyoxylate-induced protein) hyi gip ybbG b0508 JW0496 gip ybbG hyi 29,377 glyoxylate metabolic process [GO:0046487] hydroxypyruvate isomerase activity [GO:0008903]; protein homodimerization activity [GO:0042803]; glyoxylate metabolic process [GO:0046487] hydroxypyruvate isomerase activity [GO:0008903]; protein homodimerization activity [GO:0042803] GO:0008903; GO:0042803; GO:0046487 +P0AAJ8 HYBA_ECOLI Hydrogenase-2 operon protein HybA hybA b2996 JW2964 hybA 36,003 anaerobic glycerol catabolic process [GO:0019588] integral component of plasma membrane [GO:0005887]; periplasmic space [GO:0042597] integral component of plasma membrane [GO:0005887]; periplasmic space [GO:0042597]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; anaerobic glycerol catabolic process [GO:0019588] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] GO:0005887; GO:0016491; GO:0019588; GO:0042597; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Periplasm. +P37180 HYBB_ECOLI Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit hybB b2995 JW5494 hybB 43,602 anaerobic respiration [GO:0009061]; formate oxidation [GO:0015944] [Ni-Fe] hydrogenase complex [GO:0044569]; formate dehydrogenase complex [GO:0009326]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] [Ni-Fe] hydrogenase complex [GO:0044569]; formate dehydrogenase complex [GO:0009326]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; formate dehydrogenase (quinone) activity [GO:0036397]; hydrogenase (acceptor) activity [GO:0033748]; metal ion binding [GO:0046872]; anaerobic respiration [GO:0009061]; formate oxidation [GO:0015944] formate dehydrogenase (quinone) activity [GO:0036397]; hydrogenase (acceptor) activity [GO:0033748]; metal ion binding [GO:0046872] GO:0005886; GO:0005887; GO:0009061; GO:0009326; GO:0015944; GO:0016021; GO:0033748; GO:0036397; GO:0044569; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P37182 HYBD_ECOLI Hydrogenase 2 maturation protease (EC 3.4.23.-) hybD b2993 JW2961 hybD 17,751 cellular protein modification process [GO:0006464]; protein processing [GO:0016485] aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872]; cellular protein modification process [GO:0006464]; protein processing [GO:0016485] aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872] GO:0004175; GO:0004190; GO:0006464; GO:0008047; GO:0016485; GO:0046872 +P0AAN1 HYBE_ECOLI Hydrogenase-2 operon protein HybE hybE b2992 JW2960 hybE 17,964 protein maturation [GO:0051604] preprotein binding [GO:0070678]; protein maturation [GO:0051604] preprotein binding [GO:0070678] GO:0051604; GO:0070678 +P0A703 HYBF_ECOLI Hydrogenase maturation factor HybF (Hydrogenase nickel incorporation protein HybF) (Hydrogenase-2 operon protein HybF) hybF b2991 JW5493 hybF 12,697 cellular protein modification process [GO:0006464]; protein maturation [GO:0051604] nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270]; cellular protein modification process [GO:0006464]; protein maturation [GO:0051604] nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270] GO:0006464; GO:0008270; GO:0016151; GO:0051604 +P0AAM7 HYBG_ECOLI Hydrogenase maturation factor HybG (Hydrogenase-2 operon protein HybG) hybG b2990 JW2958 hybG 8,808 protein maturation [GO:0051604] carbon dioxide binding [GO:1902670]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; protein maturation [GO:0051604] carbon dioxide binding [GO:1902670]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506] GO:0005506; GO:0042802; GO:0051604; GO:1902670 +P0AEV4 HYCA_ECOLI Formate hydrogenlyase regulatory protein HycA hycA hevA b2725 JW2695 hevA hycA 17,627 +P0AAK1 HYCB_ECOLI Formate hydrogenlyase subunit 2 (FHL subunit 2) (Hydrogenase-3 component B) hycB hevB b2724 JW2694 hevB hycB 21,873 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0046872; GO:0051539 +P0A700 HYPA_ECOLI Hydrogenase maturation factor HypA hypA b2726 JW2696 hypA 13,168 cellular protein modification process [GO:0006464]; protein maturation [GO:0051604] extrinsic component of cytoplasmic side of plasma membrane [GO:0031234] extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; identical protein binding [GO:0042802]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270]; cellular protein modification process [GO:0006464]; protein maturation [GO:0051604] identical protein binding [GO:0042802]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270] GO:0006464; GO:0008270; GO:0016151; GO:0031234; GO:0042802; GO:0051604 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:22016389}. +P16429 HYCC_ECOLI Formate hydrogenlyase subunit 3 (FHL subunit 3) (Hydrogenase-3 component C) hycC hevC b2723 JW2693 hevC hycC 64,077 ATP synthesis coupled electron transport [GO:0042773] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; ATP synthesis coupled electron transport [GO:0042773] NADH dehydrogenase (ubiquinone) activity [GO:0008137] GO:0005886; GO:0008137; GO:0016021; GO:0042773 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P16430 HYCD_ECOLI Formate hydrogenlyase subunit 4 (FHL subunit 4) (Hydrogenase 3 component D) hycD hevD b2722 JW2692 hevD hycD 33,029 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; oxidoreductase activity [GO:0016491] oxidoreductase activity [GO:0016491] GO:0005886; GO:0016021; GO:0016491 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P16431 HYCE_ECOLI Formate hydrogenlyase subunit 5 (FHL subunit 5) (Hydrogenase-3 component E) hycE hevE b2721 JW2691 hevE hycE 64,980 4 iron, 4 sulfur cluster binding [GO:0051539]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; nickel cation binding [GO:0016151]; quinone binding [GO:0048038] 4 iron, 4 sulfur cluster binding [GO:0051539]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; nickel cation binding [GO:0016151]; quinone binding [GO:0048038] GO:0008137; GO:0016151; GO:0048038; GO:0051287; GO:0051539 +P16432 HYCF_ECOLI Formate hydrogenlyase subunit 6 (FHL subunit 6) (Hydrogenase-3 component F) hycF hevF b2720 JW2690 hevF hycF 20,309 aerobic respiration [GO:0009060] plasma membrane respiratory chain complex I [GO:0045272] plasma membrane respiratory chain complex I [GO:0045272]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]; aerobic respiration [GO:0009060] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on NAD(P)H [GO:0016651] GO:0009060; GO:0016651; GO:0045272; GO:0046872; GO:0051539 +P16433 HYCG_ECOLI Formate hydrogenlyase subunit 7 (FHL subunit 7) (Hydrogenase-3 component G) hycG hevG b2719 JW2689 hevG hycG 27,999 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] GO:0008137; GO:0046872; GO:0048038; GO:0051539 +P0AEV7 HYCH_ECOLI Formate hydrogenlyase maturation protein HycH hycH hevH b2718 JW2688 hevH hycH 15,465 cellular protein-containing complex assembly [GO:0034622] cellular protein-containing complex assembly [GO:0034622] GO:0034622 +P0AEV9 HYCI_ECOLI Hydrogenase 3 maturation protease (EC 3.4.23.51) (HycI protease) hycI b2717 JW2687 hycI 17,057 cellular protein modification process [GO:0006464]; protein processing [GO:0016485] aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872]; cellular protein modification process [GO:0006464]; protein processing [GO:0016485] aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872] GO:0004175; GO:0004190; GO:0006464; GO:0008047; GO:0016485; GO:0046872 +P08200 IDH_ECOLI Isocitrate dehydrogenase [NADP] (IDH) (EC 1.1.1.42) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) icd icdA icdE b1136 JW1122 icdA icdE icd 45,757 electron transport chain [GO:0022900]; glyoxylate cycle [GO:0006097]; response to oxidative stress [GO:0006979]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; isocitrate dehydrogenase (NADP+) activity [GO:0004450]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; electron transport chain [GO:0022900]; glyoxylate cycle [GO:0006097]; response to oxidative stress [GO:0006979]; tricarboxylic acid cycle [GO:0006099] isocitrate dehydrogenase (NADP+) activity [GO:0004450]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287] GO:0000287; GO:0004450; GO:0005737; GO:0005829; GO:0006097; GO:0006099; GO:0006979; GO:0022900; GO:0051287 +P0AAK4 HYDN_ECOLI Electron transport protein HydN hydN b2713 JW2683 hydN 19,026 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] GO:0009055; GO:0046872; GO:0051539 +P0AAN3 HYPB_ECOLI Hydrogenase maturation factor HypB (Hydrogenase isoenzymes nickel incorporation protein HypB) hypB b2727 JW2697 hypB 31,565 protein maturation [GO:0051604] GTP binding [GO:0005525]; GTPase activity [GO:0003924]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270]; protein maturation [GO:0051604] GTPase activity [GO:0003924]; GTP binding [GO:0005525]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270] GO:0003924; GO:0005525; GO:0008270; GO:0016151; GO:0051604 +P0AAM3 HYPC_ECOLI Hydrogenase maturation factor HypC (Chaperone-type protein HypC) (Hydrogenase accessory chaperone HypC) hypC b2728 JW2698 hypC 9,732 protein maturation [GO:0051604] carbon dioxide binding [GO:1902670]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; protein maturation [GO:0051604] carbon dioxide binding [GO:1902670]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506] GO:0005506; GO:0042802; GO:0051604; GO:1902670 +P24192 HYPD_ECOLI Hydrogenase maturation factor HypD (Hydrogenase isoenzymes formation protein HypD) hypD b2729 JW2699 hypD 41,363 cellular protein modification process [GO:0006464]; protein maturation [GO:0051604] 4 iron, 4 sulfur cluster binding [GO:0051539]; carbon monoxide binding [GO:0070025]; iron ion binding [GO:0005506]; cellular protein modification process [GO:0006464]; protein maturation [GO:0051604] 4 iron, 4 sulfur cluster binding [GO:0051539]; carbon monoxide binding [GO:0070025]; iron ion binding [GO:0005506] GO:0005506; GO:0006464; GO:0051539; GO:0051604; GO:0070025 +P69937 GDX_ECOLI Guanidinium exporter (Quaternary ammonium compound-resistance protein SugE) gdx sugE b4148 JW5738 sugE gdx 10,900 transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; solute:proton antiporter activity [GO:0015299]; transmembrane transporter activity [GO:0022857]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] solute:proton antiporter activity [GO:0015299]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0015299; GO:0022857; GO:0055085; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:14728684, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:14728684}. +P0A7A2 GPMB_ECOLI Probable phosphoglycerate mutase GpmB (EC 5.4.2.-) (PGAM) (Phosphoglyceromutase) gpmB ytjC b4395 JW4358 ytjC gpmB 24,065 glycolytic process [GO:0006096] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; intramolecular transferase activity, phosphotransferases [GO:0016868]; phosphatase activity [GO:0016791]; phosphoglycerate mutase activity [GO:0004619]; glycolytic process [GO:0006096] intramolecular transferase activity, phosphotransferases [GO:0016868]; phosphatase activity [GO:0016791]; phosphoglycerate mutase activity [GO:0004619] GO:0004619; GO:0005737; GO:0006096; GO:0016791; GO:0016868 +P63224 GMHA_ECOLI Phosphoheptose isomerase (EC 5.3.1.28) (Sedoheptulose 7-phosphate isomerase) gmhA lpcA tfrA yafI b0222 JW0212 lpcA tfrA yafI gmhA 20,815 D-glycero-D-manno-heptose 7-phosphate biosynthetic process [GO:2001061]; lipopolysaccharide core region biosynthetic process [GO:0009244]; protein homotetramerization [GO:0051289] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; carbohydrate derivative binding [GO:0097367]; D-sedoheptulose 7-phosphate isomerase activity [GO:0008968]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; D-glycero-D-manno-heptose 7-phosphate biosynthetic process [GO:2001061]; lipopolysaccharide core region biosynthetic process [GO:0009244]; protein homotetramerization [GO:0051289] carbohydrate derivative binding [GO:0097367]; D-sedoheptulose 7-phosphate isomerase activity [GO:0008968]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] GO:0005737; GO:0005829; GO:0008270; GO:0008968; GO:0009244; GO:0042802; GO:0051289; GO:0097367; GO:2001061 SUBCELLULAR LOCATION: Cytoplasm. +P0AC94 GNTP_ECOLI High-affinity gluconate transporter (Gluconate permease 3) (Gnt-III system) gntP yjiB b4321 JW4284 yjiB gntP 47,138 D-gluconate catabolic process [GO:0046177]; gluconate transmembrane transport [GO:0035429] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; carbohydrate:proton symporter activity [GO:0005351]; gluconate transmembrane transporter activity [GO:0015128]; D-gluconate catabolic process [GO:0046177]; gluconate transmembrane transport [GO:0035429] carbohydrate:proton symporter activity [GO:0005351]; gluconate transmembrane transporter activity [GO:0015128] GO:0005351; GO:0005886; GO:0005887; GO:0015128; GO:0016020; GO:0035429; GO:0046177 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0ACL0 GLPR_ECOLI Glycerol-3-phosphate regulon repressor glpR b3423 JW3386 glpR 28,048 glycerol metabolic process [GO:0006071] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; glycerol metabolic process [GO:0006071] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006071 +P76249 LEUE_ECOLI Leucine efflux protein leuE yeaS b1798 JW1787 yeaS leuE 23,201 amino acid transport [GO:0006865]; leucine transport [GO:0015820] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; L-leucine transmembrane transporter activity [GO:0015190]; amino acid transport [GO:0006865]; leucine transport [GO:0015820] amino acid transmembrane transporter activity [GO:0015171]; L-leucine transmembrane transporter activity [GO:0015190] GO:0005886; GO:0005887; GO:0006865; GO:0015171; GO:0015190; GO:0015820 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P00509 AAT_ECOLI Aspartate aminotransferase (AspAT) (EC 2.6.1.1) (Transaminase A) aspC b0928 JW0911 aspC 43,573 L-phenylalanine biosynthetic process [GO:0009094]; L-phenylalanine biosynthetic process from chorismate via phenylpyruvate [GO:0033585] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; L-tyrosine:2-oxoglutarate aminotransferase activity [GO:0004838]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]; L-phenylalanine biosynthetic process [GO:0009094]; L-phenylalanine biosynthetic process from chorismate via phenylpyruvate [GO:0033585] identical protein binding [GO:0042802]; L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; L-tyrosine:2-oxoglutarate aminotransferase activity [GO:0004838]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] GO:0004069; GO:0004838; GO:0005737; GO:0005829; GO:0008483; GO:0009094; GO:0030170; GO:0033585; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm. +P05050 ALKB_ECOLI Alpha-ketoglutarate-dependent dioxygenase AlkB (EC 1.14.11.33) (Alkylated DNA repair protein AlkB) (DNA oxidative demethylase AlkB) alkB aidD b2212 JW2200 aidD alkB 24,076 DNA dealkylation involved in DNA repair [GO:0006307]; DNA demethylation [GO:0080111]; DNA repair [GO:0006281]; oxidative demethylation [GO:0070989]; oxidative RNA demethylation [GO:0035513]; oxidative single-stranded DNA demethylation [GO:0035552]; oxidative single-stranded RNA demethylation [GO:0035553]; RNA repair [GO:0042245] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 1-ethyladenine demethylase activity [GO:0103053]; dioxygenase activity [GO:0051213]; DNA-N1-methyladenine dioxygenase activity [GO:0043734]; ferrous iron binding [GO:0008198]; oxidative DNA demethylase activity [GO:0035516]; oxidative RNA demethylase activity [GO:0035515]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA demethylation [GO:0080111]; DNA repair [GO:0006281]; oxidative demethylation [GO:0070989]; oxidative RNA demethylation [GO:0035513]; oxidative single-stranded DNA demethylation [GO:0035552]; oxidative single-stranded RNA demethylation [GO:0035553]; RNA repair [GO:0042245] 1-ethyladenine demethylase activity [GO:0103053]; dioxygenase activity [GO:0051213]; DNA-N1-methyladenine dioxygenase activity [GO:0043734]; ferrous iron binding [GO:0008198]; oxidative DNA demethylase activity [GO:0035516]; oxidative RNA demethylase activity [GO:0035515] GO:0005737; GO:0006281; GO:0006307; GO:0008198; GO:0035513; GO:0035515; GO:0035516; GO:0035552; GO:0035553; GO:0042245; GO:0043734; GO:0051213; GO:0070989; GO:0080111; GO:0103053 +P27254 ARGK_ECOLI GTPase ArgK (EC 3.6.5.-) (G-protein chaperone) argK ygfD b2918 JW2885 ygfD argK 36,704 ATP binding [GO:0005524]; GTP binding [GO:0005525]; GTPase activity [GO:0003924] ATP binding [GO:0005524]; GTPase activity [GO:0003924]; GTP binding [GO:0005525] GO:0003924; GO:0005524; GO:0005525 +P0AE14 AMPE_ECOLI Protein AmpE ampE b0111 JW0107 ampE 32,122 response to antibiotic [GO:0046677] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; response to antibiotic [GO:0046677] GO:0005886; GO:0005887; GO:0046677 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AB91 AROG_ECOLI Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive (EC 2.5.1.54) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) (DAHP synthase) (Phospho-2-keto-3-deoxyheptonate aldolase) aroG b0754 JW0737 aroG 38,010 aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; 3-deoxy-7-phosphoheptulonate synthase activity [GO:0003849]; identical protein binding [GO:0042802]; aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] 3-deoxy-7-phosphoheptulonate synthase activity [GO:0003849]; identical protein binding [GO:0042802] GO:0003849; GO:0005737; GO:0005829; GO:0008652; GO:0009073; GO:0009423; GO:0042802 +P0A951 ATDA_ECOLI Spermidine N(1)-acetyltransferase (SAT) (EC 2.3.1.57) (Spermidine/spermine N(1)-acetyltransferase) (SSAT) speG b1584 JW1576 speG 21,887 polyamine catabolic process [GO:0006598] cytoplasm [GO:0005737]; protein-containing complex [GO:0032991] cytoplasm [GO:0005737]; protein-containing complex [GO:0032991]; diamine N-acetyltransferase activity [GO:0004145]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; polyamine catabolic process [GO:0006598] diamine N-acetyltransferase activity [GO:0004145]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287] GO:0000287; GO:0004145; GO:0005737; GO:0006598; GO:0032991; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AE56 BFD_ECOLI Bacterioferritin-associated ferredoxin bfd yheA b3337 JW3299 yheA bfd 7,363 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872] 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872] GO:0046872; GO:0051537 +P77774 BAMB_ECOLI Outer membrane protein assembly factor BamB bamB yfgL b2512 JW2496 yfgL bamB 41,887 Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; protein insertion into membrane [GO:0051205] Bam protein complex [GO:1990063]; cell outer membrane [GO:0009279] Bam protein complex [GO:1990063]; cell outer membrane [GO:0009279]; identical protein binding [GO:0042802]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; protein insertion into membrane [GO:0051205] identical protein binding [GO:0042802] GO:0009279; GO:0042802; GO:0043165; GO:0051205; GO:1990063 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_00923, ECO:0000269|PubMed:15851030, ECO:0000269|PubMed:26900875, ECO:0000269|PubMed:26901871}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_00923, ECO:0000269|PubMed:15851030, ECO:0000269|PubMed:27686148}. +P77390 CITC_ECOLI [Citrate [pro-3S]-lyase] ligase (EC 6.2.1.22) (Acetate:SH-citrate lyase ligase) (Citrate lyase synthetase) citC ybeO b0618 JW0610 ybeO citC 40,077 biosynthetic process [GO:0009058]; cellular protein modification process [GO:0006464] [citrate (pro-3S)-lyase] ligase activity [GO:0008771]; ATP binding [GO:0005524]; N-acetyltransferase activity [GO:0008080]; biosynthetic process [GO:0009058]; cellular protein modification process [GO:0006464] [citrate (pro-3S)-lyase] ligase activity [GO:0008771]; ATP binding [GO:0005524]; N-acetyltransferase activity [GO:0008080] GO:0005524; GO:0006464; GO:0008080; GO:0008771; GO:0009058 +P0AGF2 CSDE_ECOLI Sulfur acceptor protein CsdE csdE ygdK b2811 JW2782 ygdK csdE 15,940 cyclic threonylcarbamoyladenosine biosynthetic process [GO:0061504] sulfur carrier activity [GO:0097163]; cyclic threonylcarbamoyladenosine biosynthetic process [GO:0061504] sulfur carrier activity [GO:0097163] GO:0061504; GO:0097163 +P0A6P7 ENGB_ECOLI Probable GTP-binding protein EngB engB yihA b3865 JW5930 yihA engB 23,561 division septum assembly [GO:0000917] cytosol [GO:0005829] cytosol [GO:0005829]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; division septum assembly [GO:0000917] GTP binding [GO:0005525]; metal ion binding [GO:0046872] GO:0000917; GO:0005525; GO:0005829; GO:0046872 +P0ABZ1 FLIG_ECOLI Flagellar motor switch protein FliG fliG fla AII.2 fla BII b1939 JW1923 fla AII.2 fla BII fliG 36,776 bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973]; chemotaxis [GO:0006935] bacterial-type flagellum basal body [GO:0009425]; plasma membrane [GO:0005886] bacterial-type flagellum basal body [GO:0009425]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; motor activity [GO:0003774]; bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973]; chemotaxis [GO:0006935] identical protein binding [GO:0042802]; motor activity [GO:0003774] GO:0003774; GO:0005886; GO:0006935; GO:0009425; GO:0042802; GO:0044780; GO:0071973 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Bacterial flagellum basal body. +P69922 FUCI_ECOLI L-fucose isomerase (FucIase) (EC 5.3.1.25) (6-deoxy-L-galactose isomerase) (D-arabinose isomerase) (EC 5.3.1.3) fucI b2802 JW2773 fucI 64,977 D-arabinose catabolic process [GO:0019571]; L-fucose catabolic process [GO:0042355] cytosol [GO:0005829] cytosol [GO:0005829]; arabinose isomerase activity [GO:0008790]; identical protein binding [GO:0042802]; L-fucose isomerase activity [GO:0008736]; manganese ion binding [GO:0030145]; D-arabinose catabolic process [GO:0019571]; L-fucose catabolic process [GO:0042355] arabinose isomerase activity [GO:0008790]; identical protein binding [GO:0042802]; L-fucose isomerase activity [GO:0008736]; manganese ion binding [GO:0030145] GO:0005829; GO:0008736; GO:0008790; GO:0019571; GO:0030145; GO:0042355; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm. +P63201 GADW_ECOLI HTH-type transcriptional regulator GadW gadW yhiW b3515 JW3483 yhiW gadW 28,028 cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003677; GO:0003700; GO:0006351; GO:0006355; GO:0006974; GO:0043565 +P0AFP6 GCH1L_ECOLI GTP cyclohydrolase 1 type 2 homolog (Radiation resistance protein YbgI) ybgI b0710 JW0700 ybgI 26,892 DNA repair [GO:0006281]; protein hexamerization [GO:0034214]; response to ionizing radiation [GO:0010212] cell pole [GO:0060187]; cytoplasm [GO:0005737]; cytosol [GO:0005829] cell pole [GO:0060187]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; DNA repair [GO:0006281]; protein hexamerization [GO:0034214]; response to ionizing radiation [GO:0010212] identical protein binding [GO:0042802]; metal ion binding [GO:0046872] GO:0005737; GO:0005829; GO:0006281; GO:0010212; GO:0034214; GO:0042802; GO:0046872; GO:0060187 +P0AES2 GUDD_ECOLI Glucarate dehydratase (GDH) (GlucD) (EC 4.2.1.40) gudD ygcX b2787 JW2758 ygcX gudD 49,141 D-glucarate catabolic process [GO:0042838] glucarate dehydratase activity [GO:0008872]; magnesium ion binding [GO:0000287]; D-glucarate catabolic process [GO:0042838] glucarate dehydratase activity [GO:0008872]; magnesium ion binding [GO:0000287] GO:0000287; GO:0008872; GO:0042838 +P0ABF4 EUTM_ECOLI Bacterial microcompartment shell protein EutM (Bacterial microcompartment protein homohexamer) (BMC-H) (Ethanolamine utilization protein EutM) eutM cchA yffZ b2457 JW2441 cchA yffZ eutM 9,866 ethanolamine catabolic process [GO:0046336]; protein hexamerization [GO:0034214] ethanolamine degradation polyhedral organelle [GO:0031471] ethanolamine degradation polyhedral organelle [GO:0031471]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; ethanolamine catabolic process [GO:0046336]; protein hexamerization [GO:0034214] identical protein binding [GO:0042802]; structural molecule activity [GO:0005198] GO:0005198; GO:0031471; GO:0034214; GO:0042802; GO:0046336 SUBCELLULAR LOCATION: Bacterial microcompartment {ECO:0000250|UniProtKB:P41791}. +P0A8V6 FADR_ECOLI Fatty acid metabolism regulator protein fadR oleR thdB b1187 JW1176 oleR thdB fadR 26,969 fatty acid oxidation [GO:0019395]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of fatty acid metabolic process [GO:0019217] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; fatty-acyl-CoA binding [GO:0000062]; fatty acid oxidation [GO:0019395]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of fatty acid metabolic process [GO:0019217] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; fatty-acyl-CoA binding [GO:0000062] GO:0000062; GO:0003677; GO:0003700; GO:0005829; GO:0019217; GO:0019395; GO:0045723; GO:0045892; GO:0045893 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00696}. +P0ABU7 EXBB_ECOLI Biopolymer transport protein ExbB exbB b3006 JW2974 exbB 26,287 bacteriocin transport [GO:0043213]; protein import [GO:0017038]; protein stabilization [GO:0050821] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; energy transducer activity [GO:0031992]; identical protein binding [GO:0042802]; transmembrane transporter activity [GO:0022857]; bacteriocin transport [GO:0043213]; protein import [GO:0017038]; protein stabilization [GO:0050821] energy transducer activity [GO:0031992]; identical protein binding [GO:0042802]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0017038; GO:0022857; GO:0031992; GO:0042802; GO:0043213; GO:0050821; GO:0098797 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AEL3 FEOA_ECOLI Fe(2+) transport protein A (Ferrous iron transport protein A) feoA b3408 JW3371 feoA 8,371 cellular response to DNA damage stimulus [GO:0006974]; ion transport [GO:0006811]; iron ion homeostasis [GO:0055072] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; transition metal ion binding [GO:0046914]; cellular response to DNA damage stimulus [GO:0006974]; ion transport [GO:0006811]; iron ion homeostasis [GO:0055072] transition metal ion binding [GO:0046914] GO:0005737; GO:0006811; GO:0006974; GO:0046914; GO:0055072 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:23104801}. +P0ABX5 FLGG_ECOLI Flagellar basal-body rod protein FlgG (Distal rod protein) flgG fla FVII flaL b1078 JW1065 fla FVII flaL flgG 27,744 bacterial-type flagellum-dependent cell motility [GO:0071973]; bacterial-type flagellum-dependent swarming motility [GO:0071978] bacterial-type flagellum basal body, distal rod [GO:0009426]; bacterial-type flagellum hook [GO:0009424]; cell outer membrane [GO:0009279] bacterial-type flagellum basal body, distal rod [GO:0009426]; bacterial-type flagellum hook [GO:0009424]; cell outer membrane [GO:0009279]; bacterial-type flagellum-dependent cell motility [GO:0071973]; bacterial-type flagellum-dependent swarming motility [GO:0071978] GO:0009279; GO:0009424; GO:0009426; GO:0071973; GO:0071978 SUBCELLULAR LOCATION: Bacterial flagellum basal body. +P37009 FBPC_ECOLI Fe(3+) ions import ATP-binding protein FbpC (EC 7.2.2.7) fbpC afuC yagC b0262 JW0254 afuC yagC fbpC 39,059 iron import into cell [GO:0033212]; transmembrane transport [GO:0055085] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; ABC-type ferric iron transporter activity [GO:0015408]; ATP binding [GO:0005524]; transmembrane transporter activity [GO:0022857]; iron import into cell [GO:0033212]; transmembrane transport [GO:0055085] ABC-type ferric iron transporter activity [GO:0015408]; ATP binding [GO:0005524]; transmembrane transporter activity [GO:0022857] GO:0005524; GO:0005886; GO:0015408; GO:0022857; GO:0033212; GO:0043190; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01706}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01706}. +P0AEL0 FDOI_ECOLI Formate dehydrogenase, cytochrome b556(fdo) subunit (Aerobic formate dehydrogenase cytochrome b556 subunit) (FDH-Z subunit gamma) (Formate dehydrogenase-O subunit gamma) fdoI b3892 JW3863 fdoI 24,606 anaerobic respiration [GO:0009061]; cellular respiration [GO:0045333]; cellular response to DNA damage stimulus [GO:0006974]; formate oxidation [GO:0015944]; respiratory electron transport chain [GO:0022904] formate dehydrogenase complex [GO:0009326]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] formate dehydrogenase complex [GO:0009326]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; formate dehydrogenase (NAD+) activity [GO:0008863]; formate dehydrogenase (quinone) activity [GO:0036397]; metal ion binding [GO:0046872]; anaerobic respiration [GO:0009061]; cellular respiration [GO:0045333]; cellular response to DNA damage stimulus [GO:0006974]; formate oxidation [GO:0015944]; respiratory electron transport chain [GO:0022904] electron transfer activity [GO:0009055]; formate dehydrogenase (NAD+) activity [GO:0008863]; formate dehydrogenase (quinone) activity [GO:0036397]; metal ion binding [GO:0046872] GO:0005886; GO:0005887; GO:0006974; GO:0008863; GO:0009055; GO:0009061; GO:0009326; GO:0015944; GO:0016021; GO:0022904; GO:0036397; GO:0045333; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AAJ3 FDNH_ECOLI Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit (Anaerobic formate dehydrogenase iron-sulfur subunit) (Formate dehydrogenase-N subunit beta) (FDH-N subunit beta) fdnH b1475 JW1471 fdnH 32,239 anaerobic respiration [GO:0009061]; formate oxidation [GO:0015944] formate dehydrogenase complex [GO:0009326]; integral component of external side of plasma membrane [GO:0071575]; membrane [GO:0016020] formate dehydrogenase complex [GO:0009326]; integral component of external side of plasma membrane [GO:0071575]; membrane [GO:0016020]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; formate dehydrogenase (quinone) activity [GO:0036397]; metal ion binding [GO:0046872]; anaerobic respiration [GO:0009061]; formate oxidation [GO:0015944] 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; formate dehydrogenase (quinone) activity [GO:0036397]; metal ion binding [GO:0046872] GO:0009055; GO:0009061; GO:0009326; GO:0015944; GO:0016020; GO:0036397; GO:0046872; GO:0051539; GO:0071575 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:11884747}; Single-pass membrane protein {ECO:0000269|PubMed:11884747}. +P11663 FUME_ECOLI Fumarase E (EC 4.2.1.2) fumE yggD b2929 JW2896 yggD fumE 19,272 fumarate hydratase activity [GO:0004333] fumarate hydratase activity [GO:0004333] GO:0004333 +P0AA80 GARP_ECOLI Probable galactarate transporter (D-galactarate permease) garP yhaU b3127 JW3096 yhaU garP 49,009 D-glucarate metabolic process [GO:0042836]; galactarate metabolic process [GO:0019580]; inorganic anion transport [GO:0015698] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; transmembrane transporter activity [GO:0022857]; D-glucarate metabolic process [GO:0042836]; galactarate metabolic process [GO:0019580]; inorganic anion transport [GO:0015698] transmembrane transporter activity [GO:0022857] GO:0005887; GO:0015698; GO:0019580; GO:0022857; GO:0042836 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P63204 GADE_ECOLI Transcriptional regulator GadE gadE yhiE yhiT b3512 JW3480 yhiE yhiT gadE 20,599 regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677] GO:0003677; GO:0006355 +P09147 GALE_ECOLI UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase) galE galD b0759 JW0742 galD galE 37,265 carbohydrate metabolic process [GO:0005975]; colanic acid biosynthetic process [GO:0009242]; galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; NAD+ binding [GO:0070403]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]; UDP-glucose 4-epimerase activity [GO:0003978]; carbohydrate metabolic process [GO:0005975]; colanic acid biosynthetic process [GO:0009242]; galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012] identical protein binding [GO:0042802]; NAD+ binding [GO:0070403]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]; UDP-glucose 4-epimerase activity [GO:0003978] GO:0003978; GO:0005737; GO:0005829; GO:0005975; GO:0006012; GO:0009242; GO:0016857; GO:0033499; GO:0042802; GO:0070403 +P0AC30 FTSX_ECOLI Cell division protein FtsX ftsX ftsS b3462 JW3427 ftsS ftsX 38,544 cell cycle [GO:0007049]; cell division [GO:0051301] cell division site [GO:0032153]; Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] cell division site [GO:0032153]; Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cell cycle [GO:0007049]; cell division [GO:0051301] GO:0005886; GO:0007049; GO:0009276; GO:0016021; GO:0032153; GO:0051301 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:10048040, ECO:0000269|PubMed:14729705, ECO:0000269|PubMed:3323846}; Multi-pass membrane protein {ECO:0000269|PubMed:10048040, ECO:0000269|PubMed:14729705, ECO:0000269|PubMed:3323846}. Note=Localizes to the septal ring at the later stages of cell growth and remains there until division is complete. This localization is dependent on localization of FtsZ, FtsA and ZipA, but not on the downstream division proteins FtsK, FtsQ or FtsI. +P76041 GGAP_ECOLI Glucosylglycerate phosphorylase (GGa phosphorylase) (GGaP) (EC 2.4.1.352) ycjM ggaP b1309 JW1302 ggaP ycjM 64,186 carbohydrate metabolic process [GO:0005975] glucosylglycerate phosphorylase activity [GO:0110068]; carbohydrate metabolic process [GO:0005975] glucosylglycerate phosphorylase activity [GO:0110068] GO:0005975; GO:0110068 +P24193 HYPE_ECOLI Carbamoyl dehydratase HypE (EC 4.2.1.-) (Hydrogenase maturation factor HypE) hypE b2730 JW2700 hypE 35,092 peptidyl-S-carbamoyl-L-cysteine dehydration [GO:0046892]; protein maturation [GO:0051604] lyase activity [GO:0016829]; peptidyl-S-carbamoyl-L-cysteine dehydration [GO:0046892]; protein maturation [GO:0051604] lyase activity [GO:0016829] GO:0016829; GO:0046892; GO:0051604 +P30131 HYPF_ECOLI Carbamoyltransferase HypF (EC 6.2.-.-) (Carbamoyl phosphate-converting enzyme HypF) ([NiFe]-hydrogenase maturation factor HypF) (Hydrogenase maturation protein HypF) hypF hydA b2712 JW5433 hydA hypF 82,066 protein carbamoylation [GO:0046944]; protein maturation [GO:0051604] carboxyl- or carbamoyltransferase activity [GO:0016743]; double-stranded RNA binding [GO:0003725]; ligase activity [GO:0016874]; zinc ion binding [GO:0008270]; protein carbamoylation [GO:0046944]; protein maturation [GO:0051604] carboxyl- or carbamoyltransferase activity [GO:0016743]; double-stranded RNA binding [GO:0003725]; ligase activity [GO:0016874]; zinc ion binding [GO:0008270] GO:0003725; GO:0008270; GO:0016743; GO:0016874; GO:0046944; GO:0051604 +P23481 HYFA_ECOLI Hydrogenase-4 component A (EC 1.-.-.-) hyfA yffE b2481 JW2466 yffE hyfA 22,154 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] GO:0016491; GO:0046872; GO:0051539 +P23482 HYFB_ECOLI Hydrogenase-4 component B (EC 1.-.-.-) hyfB yffF b2482 JW2467 yffF hyfB 72,583 ATP synthesis coupled electron transport [GO:0042773] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; ATP synthesis coupled electron transport [GO:0042773] NADH dehydrogenase (ubiquinone) activity [GO:0008137] GO:0005887; GO:0008137; GO:0042773 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305}. +P77858 HYFC_ECOLI Hydrogenase-4 component C (EC 1.-.-.-) hyfC b2483 JW2468 hyfC 34,359 cellular response to DNA damage stimulus [GO:0006974] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; oxidoreductase activity [GO:0016491]; cellular response to DNA damage stimulus [GO:0006974] oxidoreductase activity [GO:0016491] GO:0005886; GO:0005887; GO:0006974; GO:0016491 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:9278503}; Multi-pass membrane protein. +P77416 HYFD_ECOLI Hydrogenase-4 component D (EC 1.-.-.-) hyfD b2484 JW2469 hyfD 51,755 electron transport coupled proton transport [GO:0015990] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; NADH dehydrogenase activity [GO:0003954]; electron transport coupled proton transport [GO:0015990] NADH dehydrogenase activity [GO:0003954] GO:0003954; GO:0005887; GO:0015990 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0AEW1 HYFE_ECOLI Hydrogenase-4 component E (EC 1.-.-.-) hyfE b2485 JW2470 hyfE 23,361 integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; oxidoreductase activity [GO:0016491] oxidoreductase activity [GO:0016491] GO:0005887; GO:0016491 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:9278503}; Multi-pass membrane protein. +P77437 HYFF_ECOLI Hydrogenase-4 component F (EC 1.-.-.-) hyfF b2486 JW2471 hyfF 56,767 cellular response to DNA damage stimulus [GO:0006974] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; oxidoreductase activity [GO:0016491]; cellular response to DNA damage stimulus [GO:0006974] oxidoreductase activity [GO:0016491] GO:0005887; GO:0006974; GO:0016021; GO:0016491 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +Q46893 ISPD_ECOLI 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) (4-diphosphocytidyl-2C-methyl-D-erythritol synthase) (CDP-ME synthase) (MEP cytidylyltransferase) (MCT) ispD ygbP b2747 JW2717 ygbP ispD 25,737 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; terpenoid biosynthetic process [GO:0016114] cytosol [GO:0005829] cytosol [GO:0005829]; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity [GO:0050518]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; terpenoid biosynthetic process [GO:0016114] 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity [GO:0050518]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287] GO:0000287; GO:0005829; GO:0016114; GO:0019288; GO:0042802; GO:0050518 +P0AC96 GNTU_ECOLI Low-affinity gluconate transporter (Gluconate permease) (Gnt-I system) gntU b4476 JW5686 gntU 46,416 D-gluconate metabolic process [GO:0019521]; gluconate transmembrane transport [GO:0035429] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; carbohydrate:cation symporter activity [GO:0005402]; gluconate transmembrane transporter activity [GO:0015128]; D-gluconate metabolic process [GO:0019521]; gluconate transmembrane transport [GO:0035429] carbohydrate:cation symporter activity [GO:0005402]; gluconate transmembrane transporter activity [GO:0015128] GO:0005402; GO:0005886; GO:0005887; GO:0015128; GO:0019521; GO:0035429 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P68066 GRCA_ECOLI Autonomous glycyl radical cofactor grcA yfiD b2579 JW2563 yfiD grcA 14,284 threonine catabolic process [GO:0006567] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; formate C-acetyltransferase activity [GO:0008861]; threonine catabolic process [GO:0006567] formate C-acetyltransferase activity [GO:0008861] GO:0005737; GO:0005829; GO:0006567; GO:0008861 +P68688 GLRX1_ECOLI Glutaredoxin 1 (Grx1) grxA grx b0849 JW0833 grx grxA 9,685 cell redox homeostasis [GO:0045454]; deoxyribonucleotide biosynthetic process [GO:0009263] electron transfer activity [GO:0009055]; nucleotide binding [GO:0000166]; protein disulfide oxidoreductase activity [GO:0015035]; cell redox homeostasis [GO:0045454]; deoxyribonucleotide biosynthetic process [GO:0009263] electron transfer activity [GO:0009055]; nucleotide binding [GO:0000166]; protein disulfide oxidoreductase activity [GO:0015035] GO:0000166; GO:0009055; GO:0009263; GO:0015035; GO:0045454 +P0AC69 GLRX4_ECOLI Glutaredoxin 4 (Grx4) (Monothiol glutaredoxin) grxD ydhD b1654 JW1646 ydhD grxD 12,879 cytosol [GO:0005829] cytosol [GO:0005829]; 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; protein disulfide oxidoreductase activity [GO:0015035] 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; protein disulfide oxidoreductase activity [GO:0015035] GO:0005829; GO:0015035; GO:0046872; GO:0051537 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15833738}. +P75849 GLO22_ECOLI Hydroxyacylglutathione hydrolase GloC (EC 3.1.2.6) (Accessory type II glyoxalase) (Glyoxalase II 2) (GlxII-2) gloC ycbL b0927 JW0910 ycbL gloC 23,784 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]; response to toxic substance [GO:0009636] cytosol [GO:0005829] cytosol [GO:0005829]; hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872]; methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]; response to toxic substance [GO:0009636] hydroxyacylglutathione hydrolase activity [GO:0004416]; metal ion binding [GO:0046872] GO:0004416; GO:0005829; GO:0009636; GO:0019243; GO:0046872 +P0ACG8 HSLR_ECOLI Heat shock protein 15 (HSP15) hslR yrfH b3400 JW3363 yrfH hslR 15,496 cellular response to heat [GO:0034605]; response to heat [GO:0009408] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; ribosomal large subunit binding [GO:0043023]; single-stranded RNA binding [GO:0003727]; cellular response to heat [GO:0034605]; response to heat [GO:0009408] DNA binding [GO:0003677]; ribosomal large subunit binding [GO:0043023]; single-stranded RNA binding [GO:0003727] GO:0003677; GO:0003727; GO:0005829; GO:0009408; GO:0034605; GO:0043023 +P77494 HOKB_ECOLI Toxic protein HokB hokB ydcB b4428 JW5225 ydcB hokB 5,626 dormancy process [GO:0022611] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; dormancy process [GO:0022611] GO:0005887; GO:0022611 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:P0ACG4, ECO:0000305|PubMed:26051177}; Single-pass membrane protein {ECO:0000250|UniProtKB:P0ACG4}. +P26281 HPPK_ECOLI 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) folK b0142 JW0138 folK 18,079 folic acid biosynthetic process [GO:0046656]; tetrahydrofolate biosynthetic process [GO:0046654] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity [GO:0003848]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; folic acid biosynthetic process [GO:0046656]; tetrahydrofolate biosynthetic process [GO:0046654] 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity [GO:0003848]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287] GO:0000287; GO:0003848; GO:0005524; GO:0016301; GO:0046654; GO:0046656 +P0A705 IF2_ECOLI Translation initiation factor IF-2 infB gicD ssyG b3168 JW3137 gicD ssyG infB 97,350 translational initiation [GO:0006413] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanosine tetraphosphate binding [GO:0097216]; ribosomal small subunit binding [GO:0043024]; translation initiation factor activity [GO:0003743]; translational initiation [GO:0006413] GTPase activity [GO:0003924]; GTP binding [GO:0005525]; guanosine tetraphosphate binding [GO:0097216]; ribosomal small subunit binding [GO:0043024]; translation initiation factor activity [GO:0003743] GO:0003743; GO:0003924; GO:0005525; GO:0005829; GO:0006413; GO:0016020; GO:0043024; GO:0097216 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1764105}. +P75987 IRAM_ECOLI Anti-adapter protein IraM (Enhancing lycopene biosynthesis protein 1) iraM elb1 elbA ycgW b1160 JW1147 elb1 elbA ycgW iraM 12,133 cellular response to acidic pH [GO:0071468]; cellular response to magnesium starvation [GO:0010350]; negative regulation of protein catabolic process [GO:0042177] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; anti-sigma factor antagonist activity [GO:0043856]; cellular response to acidic pH [GO:0071468]; cellular response to magnesium starvation [GO:0010350]; negative regulation of protein catabolic process [GO:0042177] anti-sigma factor antagonist activity [GO:0043856] GO:0005737; GO:0010350; GO:0042177; GO:0043856; GO:0071468 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A717 KPRS_ECOLI Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase) prs prsA b1207 JW1198 prsA prs 34,218 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; nucleoside metabolic process [GO:0009116]; protein hexamerization [GO:0034214]; purine nucleotide biosynthetic process [GO:0006164]; ribonucleoside monophosphate biosynthetic process [GO:0009156] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribose phosphate diphosphokinase complex [GO:0002189] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribose phosphate diphosphokinase complex [GO:0002189]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; phosphate ion binding [GO:0042301]; ribose phosphate diphosphokinase activity [GO:0004749]; 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; nucleoside metabolic process [GO:0009116]; protein hexamerization [GO:0034214]; purine nucleotide biosynthetic process [GO:0006164]; ribonucleoside monophosphate biosynthetic process [GO:0009156] ADP binding [GO:0043531]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; phosphate ion binding [GO:0042301]; ribose phosphate diphosphokinase activity [GO:0004749] GO:0000287; GO:0002189; GO:0004749; GO:0005524; GO:0005737; GO:0005829; GO:0006015; GO:0006164; GO:0009116; GO:0009156; GO:0016301; GO:0034214; GO:0042301; GO:0042802; GO:0043531 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00583}. +P24181 ACRF_ECOLI Multidrug export protein AcrF (Acriflavine resistance protein F) (Protein EnvD) acrF envD b3266 JW3234 envD acrF 111,454 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; efflux transmembrane transporter activity [GO:0015562]; xenobiotic transmembrane transporter activity [GO:0042910] efflux transmembrane transporter activity [GO:0015562]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0015562; GO:0016021; GO:0042910 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:11274125, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:11274125, ECO:0000269|PubMed:15919996}. +P69503 APT_ECOLI Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7) apt b0469 JW0458 apt 19,859 adenine salvage [GO:0006168]; AMP salvage [GO:0044209]; purine ribonucleoside salvage [GO:0006166] cytosol [GO:0005829] cytosol [GO:0005829]; adenine phosphoribosyltransferase activity [GO:0003999]; magnesium ion binding [GO:0000287]; adenine salvage [GO:0006168]; AMP salvage [GO:0044209]; purine ribonucleoside salvage [GO:0006166] adenine phosphoribosyltransferase activity [GO:0003999]; magnesium ion binding [GO:0000287] GO:0000287; GO:0003999; GO:0005829; GO:0006166; GO:0006168; GO:0044209 SUBCELLULAR LOCATION: Cytoplasm. +P08202 ARAA_ECOLI L-arabinose isomerase (EC 5.3.1.4) araA b0062 JW0061 araA 56,074 arabinose catabolic process [GO:0019568]; L-arabinose catabolic process to xylulose 5-phosphate [GO:0019569] cytosol [GO:0005829] cytosol [GO:0005829]; L-arabinose isomerase activity [GO:0008733]; manganese ion binding [GO:0030145]; arabinose catabolic process [GO:0019568]; L-arabinose catabolic process to xylulose 5-phosphate [GO:0019569] L-arabinose isomerase activity [GO:0008733]; manganese ion binding [GO:0030145] GO:0005829; GO:0008733; GO:0019568; GO:0019569; GO:0030145 +Q47083 CBL_ECOLI HTH-type transcriptional regulator cbl cbl b1987 JW1966 cbl 35,856 cysteine biosynthetic process [GO:0019344]; positive regulation of sulfur utilization [GO:0045883]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; cysteine biosynthetic process [GO:0019344]; positive regulation of sulfur utilization [GO:0045883]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355; GO:0019344; GO:0045883 +P77218 EUTD_ECOLI Phosphate acetyltransferase EutD (EC 2.3.1.8) (Ethanolamine utilization protein EutD) eutD eutI ypfA b2458 JW2442 eutI ypfA eutD 36,067 ethanolamine catabolic process [GO:0046336]; response to heat [GO:0009408] phosphate acetyltransferase activity [GO:0008959]; ethanolamine catabolic process [GO:0046336]; response to heat [GO:0009408] phosphate acetyltransferase activity [GO:0008959] GO:0008959; GO:0009408; GO:0046336 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:21046341}. Note=It is not clear if this enzyme is found in the cytoplasm or the bacterial microcompartment. {ECO:0000305|PubMed:21046341}. +P75717 EXOD_ECOLI Putative uncharacterized protein ExoD exoD ybcC b0539 JW0526 ybcC exoD 10,509 +P0A6U8 GLGA_ECOLI Glycogen synthase (EC 2.4.1.21) (Starch [bacterial glycogen] synthase) glgA b3429 JW3392 glgA 52,822 cellular response to DNA damage stimulus [GO:0006974]; glycogen biosynthetic process [GO:0005978] cytosol [GO:0005829] cytosol [GO:0005829]; alpha-1,4-glucan synthase activity [GO:0033201]; glycogen (starch) synthase activity [GO:0004373]; starch synthase activity [GO:0009011]; cellular response to DNA damage stimulus [GO:0006974]; glycogen biosynthetic process [GO:0005978] alpha-1,4-glucan synthase activity [GO:0033201]; glycogen (starch) synthase activity [GO:0004373]; starch synthase activity [GO:0009011] GO:0004373; GO:0005829; GO:0005978; GO:0006974; GO:0009011; GO:0033201 +P15067 GLGX_ECOLI Glycogen debranching enzyme (EC 3.2.1.196) (Glycogen operon protein GlgX) (Limit dextrin alpha-1,6-maltotetraose-hydrolase) glgX glyX b3431 JW3394 glyX glgX 73,577 cellular response to DNA damage stimulus [GO:0006974]; glycogen catabolic process [GO:0005980] amylo-alpha-1,6-glucosidase activity [GO:0004135]; glycogen debranching enzyme activity [GO:0004133]; cellular response to DNA damage stimulus [GO:0006974]; glycogen catabolic process [GO:0005980] amylo-alpha-1,6-glucosidase activity [GO:0004135]; glycogen debranching enzyme activity [GO:0004133] GO:0004133; GO:0004135; GO:0005980; GO:0006974 +P75767 GNGF_ECOLI Putative gluconeogenesis factor ybhK b0780 JW0763 ybhK 32,788 regulation of cell shape [GO:0008360] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; LPPG:FO 2-phospho-L-lactate transferase activity [GO:0043743]; regulation of cell shape [GO:0008360] LPPG:FO 2-phospho-L-lactate transferase activity [GO:0043743] GO:0005737; GO:0008360; GO:0043743 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00973}. +P0AFU4 GLRR_ECOLI Transcriptional regulatory protein GlrR glrR yfhA b2554 JW2538 yfhA glrR 49,148 phosphorelay signal transduction system [GO:0000160]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; phosphorelay response regulator activity [GO:0000156]; transcription factor binding [GO:0008134]; phosphorelay signal transduction system [GO:0000160]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] ATP binding [GO:0005524]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; phosphorelay response regulator activity [GO:0000156]; transcription factor binding [GO:0008134] GO:0000156; GO:0000160; GO:0000986; GO:0003700; GO:0005524; GO:0005737; GO:0006351; GO:0008134; GO:0045893 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0ACA7 GSTB_ECOLI Glutathione S-transferase GstB (EC 2.5.1.18) gstB yliJ b0838 JW0822 yliJ gstB 23,713 glutathione metabolic process [GO:0006749] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; arsenate reductase activity [GO:0030611]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; glutathione metabolic process [GO:0006749] arsenate reductase activity [GO:0030611]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802] GO:0004364; GO:0005737; GO:0005829; GO:0006749; GO:0030611; GO:0042802; GO:0043295 +P0A6W9 GSH1_ECOLI Glutamate--cysteine ligase (EC 6.3.2.2) (Gamma-ECS) (GCS) (Gamma-glutamylcysteine synthetase) gshA gsh-I b2688 JW2663 gsh-I gshA 58,269 cellular response to arsenic-containing substance [GO:0071243]; cellular response to mercury ion [GO:0071288]; glutathione biosynthetic process [GO:0006750]; hyperosmotic response [GO:0006972] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; glutamate-cysteine ligase activity [GO:0004357]; metal ion binding [GO:0046872]; cellular response to arsenic-containing substance [GO:0071243]; cellular response to mercury ion [GO:0071288]; glutathione biosynthetic process [GO:0006750]; hyperosmotic response [GO:0006972] ATP binding [GO:0005524]; glutamate-cysteine ligase activity [GO:0004357]; metal ion binding [GO:0046872] GO:0004357; GO:0005524; GO:0005829; GO:0006750; GO:0006972; GO:0046872; GO:0071243; GO:0071288 +P52644 HSLJ_ECOLI Heat shock protein HslJ hslJ ydbI b1379 JW1374 ydbI hslJ 15,166 response to heat [GO:0009408] response to heat [GO:0009408] GO:0009408 +P0ABZ4 KDSC_ECOLI 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC (EC 3.1.3.45) (KDO 8-P phosphatase) kdsC yrbI yrbJ b3198 JW3165 yrbI yrbJ kdsC 19,997 lipopolysaccharide biosynthetic process [GO:0009103] cytosol [GO:0005829] cytosol [GO:0005829]; 3-deoxy-manno-octulosonate-8-phosphatase activity [GO:0019143]; metal ion binding [GO:0046872]; lipopolysaccharide biosynthetic process [GO:0009103] 3-deoxy-manno-octulosonate-8-phosphatase activity [GO:0019143]; metal ion binding [GO:0046872] GO:0005829; GO:0009103; GO:0019143; GO:0046872 +P30125 LEU3_ECOLI 3-isopropylmalate dehydrogenase (EC 1.1.1.85) (3-IPM-DH) (Beta-IPM dehydrogenase) (IMDH) leuB b0073 JW5807 leuB 39,517 branched-chain amino acid biosynthetic process [GO:0009082]; cellular response to amino acid starvation [GO:0034198]; leucine biosynthetic process [GO:0009098] cytosol [GO:0005829] cytosol [GO:0005829]; 3-isopropylmalate dehydrogenase activity [GO:0003862]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; branched-chain amino acid biosynthetic process [GO:0009082]; cellular response to amino acid starvation [GO:0034198]; leucine biosynthetic process [GO:0009098] 3-isopropylmalate dehydrogenase activity [GO:0003862]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; NAD binding [GO:0051287] GO:0000287; GO:0003862; GO:0005829; GO:0009082; GO:0009098; GO:0030145; GO:0034198; GO:0046872; GO:0051287 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01033}. +P02920 LACY_ECOLI Lactose permease (Lactose-proton symport) lacY b0343 JW0334 lacY 46,503 carbohydrate transport [GO:0008643]; lactose transport [GO:0015767]; organic substance transport [GO:0071702] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; carbohydrate:proton symporter activity [GO:0005351]; lactose binding [GO:0030395]; lactose:proton symporter activity [GO:0015528]; carbohydrate transport [GO:0008643]; lactose transport [GO:0015767]; organic substance transport [GO:0071702] carbohydrate:proton symporter activity [GO:0005351]; lactose:proton symporter activity [GO:0015528]; lactose binding [GO:0030395] GO:0005351; GO:0005886; GO:0005887; GO:0008643; GO:0015528; GO:0015767; GO:0016020; GO:0016021; GO:0030395; GO:0071702 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:2164211}; Multi-pass membrane protein {ECO:0000269|PubMed:2164211}. +P0CE48 EFTU2_ECOLI Elongation factor Tu 2 (EF-Tu 2) (Bacteriophage Q beta RNA-directed RNA polymerase subunit III) (P-43) tufB b3980 JW3943 tufB 43,314 response to antibiotic [GO:0046677]; translational elongation [GO:0006414] cytosol [GO:0005829]; plasma membrane [GO:0005886] cytosol [GO:0005829]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746]; response to antibiotic [GO:0046677]; translational elongation [GO:0006414] GTPase activity [GO:0003924]; GTP binding [GO:0005525]; translation elongation factor activity [GO:0003746] GO:0003746; GO:0003924; GO:0005525; GO:0005829; GO:0005886; GO:0006414; GO:0046677 SUBCELLULAR LOCATION: Cytoplasm. Cell inner membrane; Peripheral membrane protein. Note=Between 50-80% of the protein is associated with the cell inner membrane. Localization to the membrane has been suggested to follow nutrient stress. +P0A8T5 FLIE_ECOLI Flagellar hook-basal body complex protein FliE fliE fla AI flaN b1937 JW1921 fla AI flaN fliE 11,127 bacterial-type flagellum-dependent cell motility [GO:0071973] bacterial-type flagellum basal body [GO:0009425] bacterial-type flagellum basal body [GO:0009425]; motor activity [GO:0003774]; structural molecule activity [GO:0005198]; bacterial-type flagellum-dependent cell motility [GO:0071973] motor activity [GO:0003774]; structural molecule activity [GO:0005198] GO:0003774; GO:0005198; GO:0009425; GO:0071973 SUBCELLULAR LOCATION: Bacterial flagellum basal body {ECO:0000250}. +P00363 FRDA_ECOLI Fumarate reductase flavoprotein subunit (EC 1.3.5.4) (Quinol-fumarate reductase flavoprotein subunit) (QFR flavoprotein subunit) frdA b4154 JW4115 frdA 65,972 anaerobic respiration [GO:0009061]; bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973]; cellular response to DNA damage stimulus [GO:0006974]; fermentation [GO:0006113] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; plasma membrane fumarate reductase complex [GO:0045284] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; plasma membrane fumarate reductase complex [GO:0045284]; electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; fumarate reductase (menaquinone) [GO:0102040]; succinate dehydrogenase activity [GO:0000104]; anaerobic respiration [GO:0009061]; bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973]; cellular response to DNA damage stimulus [GO:0006974]; fermentation [GO:0006113] electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; fumarate reductase (menaquinone) [GO:0102040]; succinate dehydrogenase activity [GO:0000104] GO:0000104; GO:0005829; GO:0005886; GO:0006113; GO:0006974; GO:0009055; GO:0009061; GO:0016020; GO:0044780; GO:0045284; GO:0050660; GO:0071949; GO:0071973; GO:0102040 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:10373108, ECO:0000305|PubMed:20484676}; Peripheral membrane protein {ECO:0000305|PubMed:10373108}; Cytoplasmic side {ECO:0000305|PubMed:10373108}. +P0A9A9 FUR_ECOLI Ferric uptake regulation protein (Ferric uptake regulator) fur b0683 JW0669 fur 16,795 negative regulation of siderophore biosynthetic process [GO:1900705]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of secondary metabolite biosynthetic process [GO:1900376] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity [GO:0001217]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; zinc ion binding [GO:0008270]; negative regulation of siderophore biosynthetic process [GO:1900705]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of secondary metabolite biosynthetic process [GO:1900376] DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity [GO:0001217]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; zinc ion binding [GO:0008270] GO:0000976; GO:0001216; GO:0001217; GO:0003700; GO:0005829; GO:0008270; GO:0032993; GO:0043565; GO:0045892; GO:0045893; GO:1900376; GO:1900705 SUBCELLULAR LOCATION: Cytoplasm. +P0A9C3 GALM_ECOLI Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) (Type-1 mutarotase) galM b0756 JW0739 galM 38,190 galactose catabolic process via UDP-galactose [GO:0033499]; glucose metabolic process [GO:0006006] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; aldose 1-epimerase activity [GO:0004034]; carbohydrate binding [GO:0030246]; galactose catabolic process via UDP-galactose [GO:0033499]; glucose metabolic process [GO:0006006] aldose 1-epimerase activity [GO:0004034]; carbohydrate binding [GO:0030246] GO:0004034; GO:0005737; GO:0006006; GO:0030246; GO:0033499 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AF52 GHXP_ECOLI Guanine/hypoxanthine permease GhxP ghxP yjcD b4064 JW4025 yjcD ghxP 45,711 guanine import across plasma membrane [GO:0098710]; hypoxanthine transport [GO:0035344] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; guanine transmembrane transporter activity [GO:0015208]; purine nucleobase transmembrane transporter activity [GO:0005345]; guanine import across plasma membrane [GO:0098710]; hypoxanthine transport [GO:0035344] guanine transmembrane transporter activity [GO:0015208]; purine nucleobase transmembrane transporter activity [GO:0005345] GO:0005345; GO:0005886; GO:0015208; GO:0016021; GO:0035344; GO:0098710 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:24214977}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:24214977}. +P36930 GATR_ECOLI Putative galactitol utilization operon repressor gatR b4498 JW5340/JW2074 b2087/b2090 gatR 12,403 DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700 +P46859 GNTK_ECOLI Thermoresistant gluconokinase (EC 2.7.1.12) (Gluconate kinase 2) gntK b3437 JW3400 gntK 19,543 D-gluconate catabolic process [GO:0046177] ATP binding [GO:0005524]; gluconokinase activity [GO:0046316]; D-gluconate catabolic process [GO:0046177] ATP binding [GO:0005524]; gluconokinase activity [GO:0046316] GO:0005524; GO:0046177; GO:0046316 +P41443 GSPH_ECOLI Type II secretion system protein H (T2SS minor pseudopilin H) (General secretion pathway protein H) (Protein transport protein HofH) (Putative general secretion pathway protein H) gspH hofH hopH b3329 JW3291 hofH hopH gspH 18,565 protein secretion by the type II secretion system [GO:0015628] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627]; protein secretion by the type II secretion system [GO:0015628] GO:0005886; GO:0015627; GO:0015628; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:Q00515}; Single-pass membrane protein {ECO:0000255}. +P0AFX0 HPF_ECOLI Ribosome hibernation promoting factor (HPF) (Hibernation factor HPF) hpf yhbH b3203 JW3170 yhbH hpf 10,750 negative regulation of translation [GO:0017148]; negative regulation of translational elongation [GO:0045900]; primary metabolic process [GO:0044238] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627] cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; negative regulation of translation [GO:0017148]; negative regulation of translational elongation [GO:0045900]; primary metabolic process [GO:0044238] ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022] GO:0005829; GO:0017148; GO:0022627; GO:0043022; GO:0043024; GO:0044238; GO:0045900 +P37024 HRPB_ECOLI ATP-dependent RNA helicase HrpB (EC 3.6.4.13) hrpB yadO b0148 JW0144 yadO hrpB 89,148 ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; nucleic acid binding [GO:0003676]; RNA helicase activity [GO:0003724] GO:0003676; GO:0003724; GO:0005524; GO:0016787 +P43329 HRPA_ECOLI ATP-dependent RNA helicase HrpA (EC 3.6.4.13) hrpA b1413 JW5905 hrpA 149,028 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; mRNA processing [GO:0006397]; RNA modification [GO:0009451] ATP binding [GO:0005524]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; mRNA processing [GO:0006397]; RNA modification [GO:0009451] ATP binding [GO:0005524]; helicase activity [GO:0004386]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] GO:0000462; GO:0003723; GO:0003724; GO:0004386; GO:0005524; GO:0006397; GO:0009451 +P28631 HOLB_ECOLI DNA polymerase III subunit delta' (EC 2.7.7.7) holB b1099 JW1085 holB 36,937 DNA-dependent DNA replication [GO:0006261] DNA polymerase III complex [GO:0009360] DNA polymerase III complex [GO:0009360]; 3'-5' exonuclease activity [GO:0008408]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; DNA-dependent DNA replication [GO:0006261] 3'-5' exonuclease activity [GO:0008408]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887] GO:0003677; GO:0003887; GO:0006261; GO:0008408; GO:0009360 +A0A385XJL4 INSB9_ECOLI Insertion element IS1 9 protein InsB (IS1i) insB9 b4710 insB9 19,565 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CF53 INSD1_ECOLI Transposase InsD for insertion element IS2A insD1 b0361 JW0352 insD1 34,398 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0032196 +P19769 INSK_ECOLI Putative transposase InsK for insertion sequence element IS150 insK dinS b3558 JW3528 dinS insK 33,477 cellular response to DNA damage stimulus [GO:0006974]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; cellular response to DNA damage stimulus [GO:0006974]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0006974; GO:0015074; GO:0032196 +P36937 KDPF_ECOLI Potassium-transporting ATPase KdpF subunit (ATP phosphohydrolase [potassium-transporting] F chain) (Potassium-binding and translocating subunit F) (Potassium-translocating ATPase F chain) kdpF b4513 JW0687 kdpF 3,072 cation transmembrane transport [GO:0098655]; potassium ion transmembrane transport [GO:0071805]; regulation of ATPase activity [GO:0043462] integral component of plasma membrane [GO:0005887]; potassium ion-transporting ATPase complex [GO:0031004] integral component of plasma membrane [GO:0005887]; potassium ion-transporting ATPase complex [GO:0031004]; P-type potassium transmembrane transporter activity [GO:0008556]; cation transmembrane transport [GO:0098655]; potassium ion transmembrane transport [GO:0071805]; regulation of ATPase activity [GO:0043462] P-type potassium transmembrane transporter activity [GO:0008556] GO:0005887; GO:0008556; GO:0031004; GO:0043462; GO:0071805; GO:0098655 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:10608856}; Single-pass membrane protein {ECO:0000255}. +Q47689 MMUP_ECOLI Probable S-methylmethionine permease mmuP ykfD b0260 JW5027 ykfD mmuP 50,526 amino acid transmembrane transport [GO:0003333]; methionine biosynthetic process [GO:0009086]; S-methylmethionine transport [GO:0015806] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; S-methylmethionine transmembrane transporter activity [GO:0000100]; amino acid transmembrane transport [GO:0003333]; methionine biosynthetic process [GO:0009086]; S-methylmethionine transport [GO:0015806] amino acid transmembrane transporter activity [GO:0015171]; S-methylmethionine transmembrane transporter activity [GO:0000100] GO:0000100; GO:0003333; GO:0005886; GO:0009086; GO:0015171; GO:0015806; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P21151 FADA_ECOLI 3-ketoacyl-CoA thiolase FadA (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase) (Fatty acid oxidation complex subunit beta) fadA oldA b3845 JW5578 oldA fadA 40,876 fatty acid beta-oxidation [GO:0006635]; phenylacetate catabolic process [GO:0010124] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; acetyl-CoA C-acyltransferase activity [GO:0003988]; fatty acid beta-oxidation [GO:0006635]; phenylacetate catabolic process [GO:0010124] acetyl-CoA C-acyltransferase activity [GO:0003988] GO:0003988; GO:0005737; GO:0006635; GO:0010124 SUBCELLULAR LOCATION: Cytoplasm. +P63746 EUTS_ECOLI Bacterial microcompartment shell protein EutS (Ethanolamine utilization protein EutS) eutS ypfE b2462 JW2446 ypfE eutS 11,650 ethanolamine catabolic process [GO:0046336]; protein hexamerization [GO:0034214] ethanolamine degradation polyhedral organelle [GO:0031471] ethanolamine degradation polyhedral organelle [GO:0031471]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; ethanolamine catabolic process [GO:0046336]; protein hexamerization [GO:0034214] identical protein binding [GO:0042802]; structural molecule activity [GO:0005198] GO:0005198; GO:0031471; GO:0034214; GO:0042802; GO:0046336 SUBCELLULAR LOCATION: Bacterial microcompartment {ECO:0000305|PubMed:20044574}. +P77277 EUTJ_ECOLI Ethanolamine utilization protein EutJ eutJ yffW b2454 JW2438 yffW eutJ 30,082 ethanolamine catabolic process [GO:0046336] ethanolamine catabolic process [GO:0046336] GO:0046336 +P76541 EUTL_ECOLI Bacterial microcompartment shell protein EutL (BMC-T) (Ethanolamine utilization protein EutL) eutL yffJ b2439 JW2432 yffJ eutL 22,788 ethanolamine catabolic process [GO:0046336] ethanolamine degradation polyhedral organelle [GO:0031471] ethanolamine degradation polyhedral organelle [GO:0031471]; identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]; ethanolamine catabolic process [GO:0046336] identical protein binding [GO:0042802]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270] GO:0005198; GO:0008270; GO:0031471; GO:0042802; GO:0046336 SUBCELLULAR LOCATION: Bacterial microcompartment {ECO:0000305|PubMed:19451619, ECO:0000305|PubMed:20044574, ECO:0000305|PubMed:20851901}. +P04994 EX7L_ECOLI Exodeoxyribonuclease 7 large subunit (EC 3.1.11.6) (Exodeoxyribonuclease VII large subunit) (Exonuclease VII large subunit) xseA b2509 JW2493 xseA 51,832 DNA catabolic process [GO:0006308] cytoplasm [GO:0005737]; exodeoxyribonuclease VII complex [GO:0009318] cytoplasm [GO:0005737]; exodeoxyribonuclease VII complex [GO:0009318]; exodeoxyribonuclease VII activity [GO:0008855]; nucleic acid binding [GO:0003676]; DNA catabolic process [GO:0006308] exodeoxyribonuclease VII activity [GO:0008855]; nucleic acid binding [GO:0003676] GO:0003676; GO:0005737; GO:0006308; GO:0008855; GO:0009318 SUBCELLULAR LOCATION: Cytoplasm. +P10384 FADL_ECOLI Long-chain fatty acid transport protein (Outer membrane FadL protein) (Outer membrane flp protein) fadL ttr b2344 JW2341 ttr fadL 48,542 cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; ligand-gated channel activity [GO:0022834]; long-chain fatty acid transporting porin activity [GO:0015483] ligand-gated channel activity [GO:0022834]; long-chain fatty acid transporting porin activity [GO:0015483] GO:0009279; GO:0015483; GO:0016021; GO:0022834 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137}. +P77237 ESSQ_ECOLI Prophage lysis protein S homolog EssQ (Lysis protein S homolog from lambdoid prophage Qin) essQ ydfS b1556 JW5255 ydfS essQ 7,741 cytolysis [GO:0019835] cytolysis [GO:0019835] GO:0019835 +P19323 FHLA_ECOLI Formate hydrogenlyase transcriptional activator FhlA fhlA b2731 JW2701 fhlA 78,468 phosphorelay signal transduction system [GO:0000160]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829]; transcription regulator complex [GO:0005667] cytosol [GO:0005829]; transcription regulator complex [GO:0005667]; ATP binding [GO:0005524]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; identical protein binding [GO:0042802]; transcription factor binding [GO:0008134]; phosphorelay signal transduction system [GO:0000160]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; transcription, DNA-templated [GO:0006351] ATP binding [GO:0005524]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; identical protein binding [GO:0042802]; transcription factor binding [GO:0008134] GO:0000160; GO:0000986; GO:0005524; GO:0005667; GO:0005829; GO:0006351; GO:0008134; GO:0042802; GO:2000144 +P0AEL8 FIMZ_ECOLI Fimbriae Z protein fimZ ybcA b0535 JW5073 ybcA fimZ 23,664 phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677] GO:0000160; GO:0003677; GO:0005737; GO:0006355 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P08194 GLPT_ECOLI Glycerol-3-phosphate transporter (G-3-P transporter) (G-3-P permease) glpT b2240 JW2234 glpT 50,310 glycerol-3-phosphate transmembrane transport [GO:0015794]; glycerol metabolic process [GO:0006071]; glycerol transport [GO:0015793] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; glycerol-3-phosphate transmembrane transporter activity [GO:0015169]; glycerol-phosphate:inorganic phosphate antiporter activity [GO:0015527]; organophosphate:inorganic phosphate antiporter activity [GO:0015315]; glycerol metabolic process [GO:0006071]; glycerol transport [GO:0015793]; glycerol-3-phosphate transmembrane transport [GO:0015794] glycerol-3-phosphate transmembrane transporter activity [GO:0015169]; glycerol-phosphate:inorganic phosphate antiporter activity [GO:0015527]; organophosphate:inorganic phosphate antiporter activity [GO:0015315] GO:0005886; GO:0006071; GO:0015169; GO:0015315; GO:0015527; GO:0015793; GO:0015794; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P23894 HTPX_ECOLI Protease HtpX (EC 3.4.24.-) (Heat shock protein HtpX) htpX b1829 JW1818 htpX 31,923 proteolysis [GO:0006508]; response to temperature stimulus [GO:0009266] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; proteolysis [GO:0006508]; response to temperature stimulus [GO:0009266] metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] GO:0004222; GO:0005886; GO:0006508; GO:0008270; GO:0009266; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:12081643}; Multi-pass membrane protein {ECO:0000269|PubMed:12081643}. Note=Bioinformatics programs predict 4 transmembrane helices, however PhoA and Bla fusions as well as other experiments only confirm the first 2. {ECO:0000269|PubMed:12081643}. +P0ACE3 HHA_ECOLI Hemolysin expression-modulating protein Hha hha b0460 JW0449 hha 8,628 regulation of gene expression [GO:0010468] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; regulation of gene expression [GO:0010468] DNA binding [GO:0003677] GO:0003677; GO:0005829; GO:0010468 +P0AB20 HSPQ_ECOLI Heat shock protein HspQ hspQ yccV b0966 JW5970 yccV hspQ 11,779 response to heat [GO:0009408] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; response to heat [GO:0009408] DNA binding [GO:0003677] GO:0003677; GO:0005737; GO:0009408 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P76658 HLDE_ECOLI Bifunctional protein HldE [Includes: D-beta-D-heptose 7-phosphate kinase (EC 2.7.1.167) (D-beta-D-heptose 7-phosphotransferase) (D-glycero-beta-D-manno-heptose-7-phosphate kinase); D-beta-D-heptose 1-phosphate adenylyltransferase (EC 2.7.7.70) (D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase)] hldE rfaE waaE yqiF b3052 JW3024 rfaE waaE yqiF hldE 51,051 ADP-L-glycero-beta-D-manno-heptose biosynthetic process [GO:0097171]; lipopolysaccharide core region biosynthetic process [GO:0009244] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; heptose 7-phosphate kinase activity [GO:0033785]; heptose-1-phosphate adenylyltransferase activity [GO:0033786]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; ADP-L-glycero-beta-D-manno-heptose biosynthetic process [GO:0097171]; lipopolysaccharide core region biosynthetic process [GO:0009244] ATP binding [GO:0005524]; heptose-1-phosphate adenylyltransferase activity [GO:0033786]; heptose 7-phosphate kinase activity [GO:0033785]; phosphotransferase activity, alcohol group as acceptor [GO:0016773] GO:0005524; GO:0005829; GO:0009244; GO:0016773; GO:0033785; GO:0033786; GO:0097171 +P0CF09 INSA3_ECOLI Insertion element IS1 3 protein InsA (IS1c) insA3 b0275 JW0269 insA3 9,902 transposition, DNA-mediated [GO:0006313] transposition, DNA-mediated [GO:0006313] GO:0006313 +P0CF57 INSD5_ECOLI Transposase InsD for insertion element IS2I insD5 b3045 JW3013 insD5 34,398 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0032196 +P0CF29 INSB6_ECOLI Insertion element IS1 6 protein InsB (IS1e) insB6 b3445 JW3409 insB6 19,565 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P76071 INSH5_ECOLI Transposase InsH for insertion sequence element IS5Y insH5 b1370 JW1363 insH5 37,777 positive regulation of transcription, DNA-templated [GO:0045893]; transposition, DNA-mediated [GO:0006313] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; transposase activity [GO:0004803]; positive regulation of transcription, DNA-templated [GO:0045893]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0005829; GO:0006313; GO:0045893 +P03961 KDPC_ECOLI Potassium-transporting ATPase KdpC subunit (ATP phosphohydrolase [potassium-transporting] C chain) (Potassium-binding and translocating subunit C) (Potassium-translocating ATPase C chain) kdpC b0696 JW0684 kdpC 20,267 cation transmembrane transport [GO:0098655]; potassium ion transmembrane transport [GO:0071805] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; ATP binding [GO:0005524]; P-type potassium transmembrane transporter activity [GO:0008556]; cation transmembrane transport [GO:0098655]; potassium ion transmembrane transport [GO:0071805] ATP binding [GO:0005524]; P-type potassium transmembrane transporter activity [GO:0008556] GO:0005524; GO:0005886; GO:0005887; GO:0008556; GO:0031004; GO:0071805; GO:0098655 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00276, ECO:0000269|PubMed:2849541}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00276}. +P0A754 KEFF_ECOLI Glutathione-regulated potassium-efflux system ancillary protein KefF (Quinone oxidoreductase KefF) (EC 1.6.5.2) kefF yabF b0046 JW0045 yabF kefF 20,170 positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transport [GO:0006813] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; FMN binding [GO:0010181]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; NADH dehydrogenase (quinone) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transport [GO:0006813] electron transfer activity [GO:0009055]; FMN binding [GO:0010181]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; NADH dehydrogenase (quinone) activity [GO:0050136]; NADPH dehydrogenase (quinone) activity [GO:0008753] GO:0003955; GO:0005886; GO:0006813; GO:0008753; GO:0009055; GO:0010181; GO:0032414; GO:0050136; GO:1901381 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01414}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01414}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_01414}. +P0AD61 KPYK1_ECOLI Pyruvate kinase I (EC 2.7.1.40) (PK-1) pykF b1676 JW1666 pykF 50,729 glycolytic process [GO:0006096]; response to heat [GO:0009408] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; pyruvate kinase complex [GO:1902912] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; pyruvate kinase complex [GO:1902912]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743]; glycolytic process [GO:0006096]; response to heat [GO:0009408] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743] GO:0000287; GO:0004743; GO:0005524; GO:0005737; GO:0005829; GO:0006096; GO:0009408; GO:0016020; GO:0016301; GO:0030955; GO:0042802; GO:1902912 +P02943 LAMB_ECOLI Maltoporin (Maltose outer membrane channel) (Maltose-inducible porin) (Phage lambda receptor protein) lamB malB b4036 JW3996 malB lamB 49,912 cellular response to DNA damage stimulus [GO:0006974]; maltodextrin transport [GO:0042956]; polysaccharide transport [GO:0015774] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; pore complex [GO:0046930]; carbohydrate transmembrane transporter activity [GO:0015144]; maltodextrin transmembrane transporter activity [GO:0042958]; maltose transporting porin activity [GO:0015481]; porin activity [GO:0015288]; virus receptor activity [GO:0001618]; cellular response to DNA damage stimulus [GO:0006974]; maltodextrin transport [GO:0042956]; polysaccharide transport [GO:0015774] carbohydrate transmembrane transporter activity [GO:0015144]; maltodextrin transmembrane transporter activity [GO:0042958]; maltose transporting porin activity [GO:0015481]; porin activity [GO:0015288]; virus receptor activity [GO:0001618] GO:0001618; GO:0006974; GO:0009279; GO:0015144; GO:0015288; GO:0015481; GO:0015774; GO:0042956; GO:0042958; GO:0045203; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_01301, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:1988451, ECO:0000269|PubMed:4201774, ECO:0000269|Ref.9}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01301, ECO:0000269|PubMed:16079137}. +P0DPD0 LDRA_ECOLI Small toxic polypeptide LdrA ldrA b4419 JW5957 ldrA 4,014 cell death [GO:0008219] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cell death [GO:0008219] GO:0005886; GO:0008219; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:24513967}; Single-pass membrane protein {ECO:0000305|PubMed:24513967}. +P17583 CYNX_ECOLI Cyanate transport protein CynX cynX b0341 JW0332 cynX 41,361 cyanate catabolic process [GO:0009440] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; cyanate catabolic process [GO:0009440] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0009440; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P69908 DCEA_ECOLI Glutamate decarboxylase alpha (GAD-alpha) (EC 4.1.1.15) gadA gadS b3517 JW3485 gadS gadA 52,685 glutamate catabolic process [GO:0006538]; intracellular pH elevation [GO:0051454] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; glutamate decarboxylase activity [GO:0004351]; pyridoxal phosphate binding [GO:0030170]; glutamate catabolic process [GO:0006538]; intracellular pH elevation [GO:0051454] glutamate decarboxylase activity [GO:0004351]; pyridoxal phosphate binding [GO:0030170] GO:0004351; GO:0005829; GO:0006538; GO:0016020; GO:0030170; GO:0051454 +P0AEE3 DEGS_ECOLI Serine endoprotease DegS (EC 3.4.21.107) (Site-1 protease DegS) (S1P protease DegS) (Site-1-type intramembrane protease) degS hhoB htrH b3235 JW3204 hhoB htrH degS 37,581 cellular response to misfolded protein [GO:0071218]; proteolysis [GO:0006508] integral component of external side of plasma membrane [GO:0071575]; outer membrane-bounded periplasmic space [GO:0030288] integral component of external side of plasma membrane [GO:0071575]; outer membrane-bounded periplasmic space [GO:0030288]; identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; cellular response to misfolded protein [GO:0071218]; proteolysis [GO:0006508] identical protein binding [GO:0042802]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236] GO:0004252; GO:0006508; GO:0008233; GO:0008236; GO:0030288; GO:0042802; GO:0071218; GO:0071575 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:11442831}; Single-pass membrane protein {ECO:0000305|PubMed:11442831}. Note=It is unclear how this protein is anchored to the inner membrane, programs predict a signal sequence, but replacing the N-terminal 26 residues with a known signal sequence gives a protein unable to fully complement a disruption mutant. {ECO:0000269|PubMed:11442831}. +P0ACJ5 DECR_ECOLI DNA-binding transcriptional activator DecR decR ybaO b0447 JW0437 ybaO decR 17,437 cysteine catabolic process [GO:0009093]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; response to amino acid [GO:0043200] cytosol [GO:0005829] cytosol [GO:0005829]; sequence-specific DNA binding [GO:0043565]; cysteine catabolic process [GO:0009093]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; response to amino acid [GO:0043200] sequence-specific DNA binding [GO:0043565] GO:0005829; GO:0009093; GO:0043200; GO:0043565; GO:2000144 +P0AEF0 DNAC_ECOLI DNA replication protein DnaC dnaC dnaD b4361 JW4325 dnaD dnaC 27,935 DNA replication [GO:0006260]; DNA replication, synthesis of RNA primer [GO:0006269]; DNA strand elongation involved in DNA replication [GO:0006271] primosome complex [GO:1990077] primosome complex [GO:1990077]; ATP binding [GO:0005524]; DNA replication [GO:0006260]; DNA replication, synthesis of RNA primer [GO:0006269]; DNA strand elongation involved in DNA replication [GO:0006271] ATP binding [GO:0005524] GO:0005524; GO:0006260; GO:0006269; GO:0006271; GO:1990077 +Q47150 DINJ_ECOLI Antitoxin DinJ dinJ b0226 JW0216 dinJ 9,406 negative regulation of DNA-templated transcription, initiation [GO:2000143]; single-species biofilm formation [GO:0044010]; transcription, DNA-templated [GO:0006351] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA binding [GO:0003677]; toxic substance binding [GO:0015643]; negative regulation of DNA-templated transcription, initiation [GO:2000143]; single-species biofilm formation [GO:0044010]; transcription, DNA-templated [GO:0006351] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA binding [GO:0003677]; toxic substance binding [GO:0015643] GO:0000986; GO:0003677; GO:0006351; GO:0015643; GO:0044010; GO:2000143 +Q47155 DPO4_ECOLI DNA polymerase IV (Pol IV) (EC 2.7.7.7) (Translesion synthesis polymerase IV) (TSL polymerase IV) dinB dinP b0231 JW0221 dinP dinB 39,516 cellular response to DNA damage stimulus [GO:0006974]; DNA-dependent DNA replication [GO:0006261]; DNA synthesis involved in DNA repair [GO:0000731]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; SOS response [GO:0009432] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; magnesium ion binding [GO:0000287]; cellular response to DNA damage stimulus [GO:0006974]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-dependent DNA replication [GO:0006261]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; SOS response [GO:0009432] damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; magnesium ion binding [GO:0000287] GO:0000287; GO:0000731; GO:0003684; GO:0003887; GO:0005737; GO:0006261; GO:0006974; GO:0009432; GO:0042276; GO:0070987 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P77510 DPIB_ECOLI Sensor histidine kinase DpiB (EC 2.7.13.3) (Sensor histidine kinase CitA) dpiB citA mpdB ybeP b0619 JW0611 citA mpdB ybeP dpiB 61,684 peptidyl-histidine phosphorylation [GO:0018106]; protein autophosphorylation [GO:0046777]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; histidine phosphotransfer kinase activity [GO:0009927]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673]; peptidyl-histidine phosphorylation [GO:0018106]; protein autophosphorylation [GO:0046777]; regulation of transcription, DNA-templated [GO:0006355] ATP binding [GO:0005524]; histidine phosphotransfer kinase activity [GO:0009927]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673] GO:0000155; GO:0004673; GO:0005524; GO:0005829; GO:0005886; GO:0005887; GO:0006355; GO:0009927; GO:0018106; GO:0030288; GO:0046777 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0AB24 EFEO_ECOLI Iron uptake system component EfeO efeO ycdO b1018 JW1003 ycdO efeO 41,138 response to antibiotic [GO:0046677]; response to oxidative stress [GO:0006979]; response to toxic substance [GO:0009636]; response to UV [GO:0009411] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; response to antibiotic [GO:0046677]; response to oxidative stress [GO:0006979]; response to toxic substance [GO:0009636]; response to UV [GO:0009411] GO:0006979; GO:0009411; GO:0009636; GO:0030288; GO:0046677 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:16551627}. +P30870 GLNE_ECOLI Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme (ATP:glutamine synthetase adenylyltransferase) (ATase) [Includes: Glutamine synthetase adenylyl-L-tyrosine phosphorylase (EC 2.7.7.89) (Adenylyl removase) (AR) (AT-N) (AT-N440) (P-I); Glutamine synthetase adenylyl transferase (EC 2.7.7.42) (Adenylyl transferase) (AT) (AT-C)] glnE b3053 JW3025 glnE 108,418 regulation of glutamine family amino acid metabolic process [GO:0000820] cytosol [GO:0005829] cytosol [GO:0005829]; [glutamate-ammonia-ligase] adenylyltransferase activity [GO:0008882]; [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase [GO:0047388]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; regulation of glutamine family amino acid metabolic process [GO:0000820] [glutamate-ammonia-ligase] adenylyltransferase activity [GO:0008882]; [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase [GO:0047388]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287] GO:0000287; GO:0000820; GO:0005524; GO:0005829; GO:0008882; GO:0047388 +P77453 HYFJ_ECOLI Hydrogenase-4 component J (EC 1.-.-.-) hyfJ b2490 JW2475 hyfJ 15,577 oxidoreductase activity [GO:0016491] oxidoreductase activity [GO:0016491] GO:0016491 +P37647 KDGK_ECOLI 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) (2-keto-3-deoxygluconokinase) (3-deoxy-2-oxo-D-gluconate kinase) (KDG kinase) kdgK yhjI b3526 JW5668 yhjI kdgK 33,962 cellular response to DNA damage stimulus [GO:0006974]; D-galacturonate catabolic process [GO:0019698]; D-glucuronate catabolic process [GO:0042840] cytosol [GO:0005829] cytosol [GO:0005829]; 2-dehydro-3-deoxygluconokinase activity [GO:0008673]; ATP binding [GO:0005524]; cellular response to DNA damage stimulus [GO:0006974]; D-galacturonate catabolic process [GO:0019698]; D-glucuronate catabolic process [GO:0042840] 2-dehydro-3-deoxygluconokinase activity [GO:0008673]; ATP binding [GO:0005524] GO:0005524; GO:0005829; GO:0006974; GO:0008673; GO:0019698; GO:0042840 +Q47690 MMUM_ECOLI Homocysteine S-methyltransferase (EC 2.1.1.10) (S-methylmethionine:homocysteine methyltransferase) mmuM yagD b0261 JW0253 yagD mmuM 33,423 cellular response to DNA damage stimulus [GO:0006974]; methionine biosynthetic process [GO:0009086]; methylation [GO:0032259]; S-methylmethionine cycle [GO:0033528]; S-methylmethionine metabolic process [GO:0033477] betaine-homocysteine S-methyltransferase activity [GO:0047150]; S-adenosylmethionine-homocysteine S-methyltransferase activity [GO:0008898]; S-methylmethionine-homocysteine S-methyltransferase activity [GO:0061627]; zinc ion binding [GO:0008270]; cellular response to DNA damage stimulus [GO:0006974]; methionine biosynthetic process [GO:0009086]; methylation [GO:0032259]; S-methylmethionine cycle [GO:0033528]; S-methylmethionine metabolic process [GO:0033477] betaine-homocysteine S-methyltransferase activity [GO:0047150]; S-adenosylmethionine-homocysteine S-methyltransferase activity [GO:0008898]; S-methylmethionine-homocysteine S-methyltransferase activity [GO:0061627]; zinc ion binding [GO:0008270] GO:0006974; GO:0008270; GO:0008898; GO:0009086; GO:0032259; GO:0033477; GO:0033528; GO:0047150; GO:0061627 +P23845 CYSN_ECOLI Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) (ATP-sulfurylase large subunit) (Sulfate adenylate transferase) (SAT) cysN b2751 JW2721 cysN 52,558 hydrogen sulfide biosynthetic process [GO:0070814]; sulfate assimilation [GO:0000103]; sulfur compound metabolic process [GO:0006790] ATP binding [GO:0005524]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; sulfate adenylyltransferase (ATP) activity [GO:0004781]; hydrogen sulfide biosynthetic process [GO:0070814]; sulfate assimilation [GO:0000103]; sulfur compound metabolic process [GO:0006790] ATP binding [GO:0005524]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; sulfate adenylyltransferase (ATP) activity [GO:0004781] GO:0000103; GO:0003924; GO:0004781; GO:0005524; GO:0005525; GO:0006790; GO:0070814 +P69913 CSRA_ECOLI Carbon storage regulator (Translational dual regulator CsrA) csrA zfiA b2696 JW2666 zfiA csrA 6,856 mRNA catabolic process [GO:0006402]; mRNA stabilization [GO:0048255]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of mRNA cleavage [GO:0031438]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; positive regulation of translational initiation [GO:0045948] cytosol [GO:0005829] cytosol [GO:0005829]; mRNA 5'-UTR binding [GO:0048027]; mRNA catabolic process [GO:0006402]; mRNA stabilization [GO:0048255]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of mRNA cleavage [GO:0031438]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; positive regulation of translational initiation [GO:0045948] mRNA 5'-UTR binding [GO:0048027] GO:0005829; GO:0006402; GO:0017148; GO:0031438; GO:0045719; GO:0045947; GO:0045948; GO:0048027; GO:0048255 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00167}. +P32144 CSQR_ECOLI HTH-type transcriptional repressor CsqR (Regulator of sulfoquinovose catabolism) csqR yihW b3884 JW5567 yihW csqR 28,507 negative regulation of DNA-templated transcription, initiation [GO:2000143] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of DNA-templated transcription, initiation [GO:2000143] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:2000143 +P0A6L2 DAPA_ECOLI 4-hydroxy-tetrahydrodipicolinate synthase (HTPA synthase) (EC 4.3.3.7) dapA b2478 JW2463 dapA 31,270 diaminopimelate biosynthetic process [GO:0019877]; lysine biosynthetic process via diaminopimelate [GO:0009089] cytosol [GO:0005829] cytosol [GO:0005829]; 4-hydroxy-tetrahydrodipicolinate synthase activity [GO:0008840]; identical protein binding [GO:0042802]; diaminopimelate biosynthetic process [GO:0019877]; lysine biosynthetic process via diaminopimelate [GO:0009089] 4-hydroxy-tetrahydrodipicolinate synthase activity [GO:0008840]; identical protein binding [GO:0042802] GO:0005829; GO:0008840; GO:0009089; GO:0019877; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm. +P0A9P6 DEAD_ECOLI ATP-dependent RNA helicase DeaD (EC 3.6.4.13) (Cold-shock DEAD box protein A) (Translation factor W2) deaD csdA mssB rhlD b3162 JW5531 csdA mssB rhlD deaD 70,546 cellular response to cold [GO:0070417]; mRNA stabilization [GO:0048255]; positive regulation of translation [GO:0045727]; response to radiation [GO:0009314]; ribosomal large subunit assembly [GO:0000027]; RNA catabolic process [GO:0006401] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA strand annealing activity [GO:0033592]; cellular response to cold [GO:0070417]; mRNA stabilization [GO:0048255]; positive regulation of translation [GO:0045727]; response to radiation [GO:0009314]; ribosomal large subunit assembly [GO:0000027]; RNA catabolic process [GO:0006401] ATP binding [GO:0005524]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA strand annealing activity [GO:0033592] GO:0000027; GO:0003723; GO:0003724; GO:0005524; GO:0005829; GO:0006401; GO:0009314; GO:0033592; GO:0045727; GO:0048255; GO:0070417 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00964, ECO:0000269|PubMed:8552679}. +P0AC44 DHSD_ECOLI Succinate dehydrogenase hydrophobic membrane anchor subunit sdhD b0722 JW0712 sdhD 12,868 aerobic respiration [GO:0009060]; cytochrome complex assembly [GO:0017004]; tricarboxylic acid cycle [GO:0006099] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; succinate dehydrogenase activity [GO:0000104]; aerobic respiration [GO:0009060]; cytochrome complex assembly [GO:0017004]; tricarboxylic acid cycle [GO:0006099] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; succinate dehydrogenase activity [GO:0000104] GO:0000104; GO:0005886; GO:0006099; GO:0009055; GO:0009060; GO:0016021; GO:0017004; GO:0020037; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P27296 DING_ECOLI ATP-dependent DNA helicase DinG (EC 3.6.4.12) dinG rarB b0799 JW0784 rarB dinG 81,440 DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; SOS response [GO:0009432] 4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; DNA/RNA helicase activity [GO:0033677]; metal ion binding [GO:0046872]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; SOS response [GO:0009432] 4 iron, 4 sulfur cluster binding [GO:0051539]; ATPase activity [GO:0016887]; ATP binding [GO:0005524]; DNA/RNA helicase activity [GO:0033677]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; metal ion binding [GO:0046872] GO:0003677; GO:0003678; GO:0005524; GO:0006281; GO:0006310; GO:0009432; GO:0016887; GO:0032508; GO:0033677; GO:0046872; GO:0051539 +P15723 DGTP_ECOLI Deoxyguanosinetriphosphate triphosphohydrolase (dGTP triphosphohydrolase) (dGTPase) (EC 3.1.5.1) dgt b0160 JW0156 dgt 59,383 dGTP catabolic process [GO:0006203]; nucleobase-containing small molecule interconversion [GO:0015949] cobalt ion binding [GO:0050897]; dGTPase activity [GO:0008832]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; single-stranded DNA binding [GO:0003697]; dGTP catabolic process [GO:0006203]; nucleobase-containing small molecule interconversion [GO:0015949] cobalt ion binding [GO:0050897]; dGTPase activity [GO:0008832]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; single-stranded DNA binding [GO:0003697] GO:0000287; GO:0003697; GO:0003924; GO:0006203; GO:0008832; GO:0015949; GO:0030145; GO:0042802; GO:0050897 +P06966 DICA_ECOLI HTH-type transcriptional regulator DicA (Repressor protein of division inhibition gene dicA) dicA b1570 JW1562 dicA 15,656 cell cycle [GO:0007049]; cell division [GO:0051301]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; cell cycle [GO:0007049]; cell division [GO:0051301]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677] GO:0003677; GO:0006351; GO:0007049; GO:0051301 +P76237 DGCJ_ECOLI Probable diguanylate cyclase DgcJ (DGC) (EC 2.7.7.65) dgcJ yeaJ b1786 JW5291 yeaJ dgcJ 56,603 cell adhesion involved in single-species biofilm formation [GO:0043709]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; cell adhesion involved in single-species biofilm formation [GO:0043709]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201] diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872] GO:0005525; GO:0005886; GO:0016021; GO:0043709; GO:0046872; GO:0052621; GO:1902201 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P0A993 F16PA_ECOLI Fructose-1,6-bisphosphatase class 1 (FBPase class 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1) fbp fdp b4232 JW4191 fdp fbp 36,834 fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; sucrose biosynthetic process [GO:0005986] cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; sucrose biosynthetic process [GO:0005986] fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166] GO:0000166; GO:0000287; GO:0005737; GO:0005829; GO:0005986; GO:0006000; GO:0006002; GO:0006094; GO:0030388; GO:0032991; GO:0042132; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01855, ECO:0000305}. +P0A6R0 FABH_ECOLI 3-oxoacyl-[acyl-carrier-protein] synthase 3 (EC 2.3.1.180) (3-oxoacyl-[acyl-carrier-protein] synthase III) (Beta-ketoacyl-ACP synthase III) (KAS III) (EcFabH) fabH b1091 JW1077 fabH 33,515 fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631] cytosol [GO:0005829] cytosol [GO:0005829]; 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; beta-ketoacyl-acyl-carrier-protein synthase III activity [GO:0033818]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631] 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; beta-ketoacyl-acyl-carrier-protein synthase III activity [GO:0033818] GO:0004315; GO:0005829; GO:0006631; GO:0006633; GO:0033818 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01815}. +P0A9R2 ESSD_ECOLI Prophage lysis protein S homolog EssD (Lysis protein S homolog from lambdoid prophage DLP12) essD ybcR b0554 JW0543 ybcR essD 7,778 cytolysis [GO:0019835]; viral release from host cell by cytolysis [GO:0044659] cytolysis [GO:0019835]; viral release from host cell by cytolysis [GO:0044659] GO:0019835; GO:0044659 +P0CB39 EPTC_ECOLI Phosphoethanolamine transferase EptC (EC 2.7.-.-) eptC cptA yijP b3955 JW3927 cptA yijP eptC 66,610 lipopolysaccharide core region biosynthetic process [GO:0009244] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; phosphotransferase activity, phosphate group as acceptor [GO:0016776]; sulfuric ester hydrolase activity [GO:0008484]; lipopolysaccharide core region biosynthetic process [GO:0009244] phosphotransferase activity, phosphate group as acceptor [GO:0016776]; sulfuric ester hydrolase activity [GO:0008484] GO:0005886; GO:0008484; GO:0009244; GO:0016021; GO:0016776 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137}. +P68646 FIXX_ECOLI Ferredoxin-like protein FixX fixX yaaT b0044 JW0043 yaaT fixX 10,479 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506] 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506] GO:0005506; GO:0051539 +P23878 FEPC_ECOLI Ferric enterobactin transport ATP-binding protein FepC fepC b0588 JW0580 fepC 29,784 ferric-enterobactin import into cell [GO:0015685] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ferric-enterobactin transmembrane transporter activity [GO:0015620]; ferric-enterobactin import into cell [GO:0015685] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; ferric-enterobactin transmembrane transporter activity [GO:0015620] GO:0005524; GO:0005886; GO:0015620; GO:0015685; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P0ABX8 FLIL_ECOLI Flagellar protein FliL fliL cheC1 fla AI fla QI b1944 JW1928 cheC1 fla AI fla QI fliL 17,221 bacterial-type flagellum-dependent swarming motility [GO:0071978]; chemotaxis [GO:0006935] bacterial-type flagellum basal body [GO:0009425]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] bacterial-type flagellum basal body [GO:0009425]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; bacterial-type flagellum-dependent swarming motility [GO:0071978]; chemotaxis [GO:0006935] GO:0005886; GO:0006935; GO:0009425; GO:0016021; GO:0071978 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P0AC05 FLIP_ECOLI Flagellar biosynthetic protein FliP fliP flaR b1948 JW1932 flaR fliP 26,928 bacterial-type flagellum organization [GO:0044781]; protein secretion [GO:0009306] bacterial-type flagellum basal body [GO:0009425]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] bacterial-type flagellum basal body [GO:0009425]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; bacterial-type flagellum organization [GO:0044781]; protein secretion [GO:0009306] GO:0005886; GO:0009306; GO:0009425; GO:0016021; GO:0044781 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. Bacterial flagellum basal body {ECO:0000269|PubMed:15919996}. +P60566 FIXA_ECOLI Protein FixA fixA yaaQ b0041 JW0040 yaaQ fixA 27,144 carnitine catabolic process [GO:0042413]; carnitine metabolic process [GO:0009437] electron transfer activity [GO:0009055]; carnitine catabolic process [GO:0042413]; carnitine metabolic process [GO:0009437] electron transfer activity [GO:0009055] GO:0009055; GO:0009437; GO:0042413 +P22256 GABT_ECOLI 4-aminobutyrate aminotransferase GabT (EC 2.6.1.19) (5-aminovalerate transaminase) (EC 2.6.1.48) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (Glutamate:succinic semialdehyde transaminase) (L-AIBAT) gabT b2662 JW2637 gabT 45,775 arginine biosynthetic process via ornithine [GO:0042450]; gamma-aminobutyric acid catabolic process [GO:0009450] cytosol [GO:0005829] cytosol [GO:0005829]; 4-aminobutyrate transaminase activity [GO:0003867]; 4-aminobutyrate:2-oxoglutarate transaminase activity [GO:0034386]; 5-aminovalerate transaminase activity [GO:0047589]; N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity [GO:0003992]; pyridoxal phosphate binding [GO:0030170]; arginine biosynthetic process via ornithine [GO:0042450]; gamma-aminobutyric acid catabolic process [GO:0009450] 4-aminobutyrate:2-oxoglutarate transaminase activity [GO:0034386]; 4-aminobutyrate transaminase activity [GO:0003867]; 5-aminovalerate transaminase activity [GO:0047589]; N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity [GO:0003992]; pyridoxal phosphate binding [GO:0030170] GO:0003867; GO:0003992; GO:0005829; GO:0009450; GO:0030170; GO:0034386; GO:0042450; GO:0047589 +P45539 FRLA_ECOLI Probable fructoselysine/psicoselysine transporter FrlA frlA yhfM b3370 JW3333 yhfM frlA 47,577 fructoselysine catabolic process [GO:1901281] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; L-amino acid transmembrane transporter activity [GO:0015179]; fructoselysine catabolic process [GO:1901281] L-amino acid transmembrane transporter activity [GO:0015179] GO:0005886; GO:0015179; GO:0016021; GO:1901281 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P23524 GLXK1_ECOLI Glycerate 2-kinase (EC 2.7.1.165) (Glycerate kinase 1) (GK1) garK yhaD b3124 JW3093 yhaD garK 39,104 D-glucarate catabolic process [GO:0042838]; galactarate catabolic process [GO:0046392]; organic acid phosphorylation [GO:0031388] ATP binding [GO:0005524]; glycerate 2-kinase activity [GO:0043798]; glycerate kinase activity [GO:0008887]; D-glucarate catabolic process [GO:0042838]; galactarate catabolic process [GO:0046392]; organic acid phosphorylation [GO:0031388] ATP binding [GO:0005524]; glycerate 2-kinase activity [GO:0043798]; glycerate kinase activity [GO:0008887] GO:0005524; GO:0008887; GO:0031388; GO:0042838; GO:0043798; GO:0046392 +P67701 HIGA_ECOLI Antitoxin HigA higA ygjM b3082 JW3053 ygjM higA 14,995 regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677] GO:0003677; GO:0006355 +P06986 HIS8_ECOLI Histidinol-phosphate aminotransferase (EC 2.6.1.9) (Imidazole acetol-phosphate transaminase) (HPAT) (HspAT) hisC b2021 JW2003 hisC 39,360 histidine biosynthetic process [GO:0000105] cytosol [GO:0005829] cytosol [GO:0005829]; histidinol-phosphate transaminase activity [GO:0004400]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; histidine biosynthetic process [GO:0000105] histidinol-phosphate transaminase activity [GO:0004400]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170] GO:0000105; GO:0004400; GO:0005829; GO:0030170; GO:0042802 +P23874 HIPA_ECOLI Serine/threonine-protein kinase toxin HipA (Ser/Thr-protein kinase HipA) (EC 2.7.11.1) (Toxin HipA) hipA b1507 JW1500 hipA 49,276 dormancy process [GO:0022611]; negative regulation of catalytic activity [GO:0043086]; peptidyl-serine autophosphorylation [GO:0036289]; response to antibiotic [GO:0046677]; single-species biofilm formation [GO:0044010] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; ATP binding [GO:0005524]; DNA-binding transcription repressor activity [GO:0001217]; magnesium ion binding [GO:0000287]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein threonine kinase activity [GO:0106311]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; dormancy process [GO:0022611]; negative regulation of catalytic activity [GO:0043086]; peptidyl-serine autophosphorylation [GO:0036289]; response to antibiotic [GO:0046677]; single-species biofilm formation [GO:0044010] ATP binding [GO:0005524]; DNA-binding transcription repressor activity [GO:0001217]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674]; protein serine kinase activity [GO:0106310]; protein threonine kinase activity [GO:0106311]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000287; GO:0000976; GO:0001217; GO:0004674; GO:0005524; GO:0005829; GO:0022611; GO:0032993; GO:0036289; GO:0043086; GO:0043565; GO:0044010; GO:0046677; GO:0106310; GO:0106311 +P0A9Q5 ACCD_ECOLI Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (ACCase subunit beta) (Acetyl-CoA carboxylase carboxyltransferase subunit beta) (EC 2.1.3.15) accD dedB usg b2316 JW2313 dedB usg accD 33,322 fatty acid biosynthetic process [GO:0006633]; long-chain fatty acid biosynthetic process [GO:0042759]; malonyl-CoA biosynthetic process [GO:2001295]; negative regulation of translation [GO:0017148] acetate CoA-transferase complex [GO:0009329]; cytosol [GO:0005829] acetate CoA-transferase complex [GO:0009329]; cytosol [GO:0005829]; acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; carboxyl- or carbamoyltransferase activity [GO:0016743]; DNA binding [GO:0003677]; mRNA binding [GO:0003729]; zinc ion binding [GO:0008270]; fatty acid biosynthetic process [GO:0006633]; long-chain fatty acid biosynthetic process [GO:0042759]; malonyl-CoA biosynthetic process [GO:2001295]; negative regulation of translation [GO:0017148] acetyl-CoA carboxylase activity [GO:0003989]; ATP binding [GO:0005524]; carboxyl- or carbamoyltransferase activity [GO:0016743]; DNA binding [GO:0003677]; mRNA binding [GO:0003729]; zinc ion binding [GO:0008270] GO:0003677; GO:0003729; GO:0003989; GO:0005524; GO:0005829; GO:0006633; GO:0008270; GO:0009329; GO:0016743; GO:0017148; GO:0042759; GO:2001295 SUBCELLULAR LOCATION: Cytoplasm. +P00561 AK1H_ECOLI Bifunctional aspartokinase/homoserine dehydrogenase 1 (Aspartokinase I/homoserine dehydrogenase I) (AKI-HDI) [Includes: Aspartokinase (EC 2.7.2.4); Homoserine dehydrogenase (EC 1.1.1.3)] thrA thrA1 thrA2 b0002 JW0001 thrA1 thrA2 thrA 89,120 homoserine biosynthetic process [GO:0009090]; lysine biosynthetic process via diaminopimelate [GO:0009089]; threonine biosynthetic process [GO:0009088] aspartate kinase activity [GO:0004072]; ATP binding [GO:0005524]; homoserine dehydrogenase activity [GO:0004412]; NADP binding [GO:0050661]; homoserine biosynthetic process [GO:0009090]; lysine biosynthetic process via diaminopimelate [GO:0009089]; threonine biosynthetic process [GO:0009088] aspartate kinase activity [GO:0004072]; ATP binding [GO:0005524]; homoserine dehydrogenase activity [GO:0004412]; NADP binding [GO:0050661] GO:0004072; GO:0004412; GO:0005524; GO:0009088; GO:0009089; GO:0009090; GO:0050661 +P38036 CAS3_ECOLI CRISPR-associated endonuclease/helicase Cas3 (EC 3.1.-.-) (EC 3.6.4.-) ygcB cas3 b2761 JW2731 cas3 ygcB 100,545 defense response to virus [GO:0051607]; DNA catabolic process, endonucleolytic [GO:0000737]; DNA catabolic process, exonucleolytic [GO:0000738]; ribosomal large subunit assembly [GO:0000027] cytosol [GO:0005829] cytosol [GO:0005829]; 3'-5'-exodeoxyribonuclease activity [GO:0008296]; ATP binding [GO:0005524]; DNA/RNA helicase activity [GO:0033677]; DNA/RNA hybrid annealing activity [GO:0097098]; double-stranded DNA binding [GO:0003690]; magnesium ion binding [GO:0000287]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA strand annealing activity [GO:0033592]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; defense response to virus [GO:0051607]; DNA catabolic process, endonucleolytic [GO:0000737]; DNA catabolic process, exonucleolytic [GO:0000738]; ribosomal large subunit assembly [GO:0000027] 3'-5'-exodeoxyribonuclease activity [GO:0008296]; ATP binding [GO:0005524]; DNA/RNA helicase activity [GO:0033677]; DNA/RNA hybrid annealing activity [GO:0097098]; double-stranded DNA binding [GO:0003690]; magnesium ion binding [GO:0000287]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA strand annealing activity [GO:0033592]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014] GO:0000014; GO:0000027; GO:0000287; GO:0000737; GO:0000738; GO:0003690; GO:0003723; GO:0003724; GO:0005524; GO:0005829; GO:0008296; GO:0033592; GO:0033677; GO:0051607; GO:0097098 +P0A6F1 CARA_ECOLI Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) (Carbamoyl-phosphate synthetase glutamine chain) carA pyrA b0032 JW0030 pyrA carA 41,431 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; arginine biosynthetic process [GO:0006526]; glutamine metabolic process [GO:0006541]; nitrogen compound metabolic process [GO:0006807] carbamoyl-phosphate synthase complex [GO:0005951]; cytoplasm [GO:0005737]; cytosol [GO:0005829] carbamoyl-phosphate synthase complex [GO:0005951]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; arginine biosynthetic process [GO:0006526]; glutamine metabolic process [GO:0006541]; nitrogen compound metabolic process [GO:0006807] ATP binding [GO:0005524]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088] GO:0004088; GO:0005524; GO:0005737; GO:0005829; GO:0005951; GO:0006207; GO:0006526; GO:0006541; GO:0006807; GO:0044205 +P08368 CREB_ECOLI Transcriptional regulatory protein CreB creB yjjE b4398 JW4361 yjjE creB 26,125 positive regulation of transcription, DNA-templated [GO:0045893] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216]; identical protein binding [GO:0042802]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; positive regulation of transcription, DNA-templated [GO:0045893] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216]; identical protein binding [GO:0042802]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000976; GO:0000986; GO:0001216; GO:0005829; GO:0032993; GO:0042802; GO:0045893 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P25524 CODA_ECOLI Cytosine deaminase (CD) (CDA) (CDase) (EC 3.5.4.1) (Cytosine aminohydrolase) (Isoguanine deaminase) (EC 3.5.4.-) codA b0337 JW0328 codA 47,591 cytosine catabolic process [GO:0006209] cytosol [GO:0005829] cytosol [GO:0005829]; 5-fluorocytosine deaminase activity [GO:0102480]; cytosine deaminase activity [GO:0004131]; ferrous iron binding [GO:0008198]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [GO:0016814]; identical protein binding [GO:0042802]; isoguanine deaminase activity [GO:0035888]; zinc ion binding [GO:0008270]; cytosine catabolic process [GO:0006209] 5-fluorocytosine deaminase activity [GO:0102480]; cytosine deaminase activity [GO:0004131]; ferrous iron binding [GO:0008198]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [GO:0016814]; identical protein binding [GO:0042802]; isoguanine deaminase activity [GO:0035888]; zinc ion binding [GO:0008270] GO:0004131; GO:0005829; GO:0006209; GO:0008198; GO:0008270; GO:0016814; GO:0035888; GO:0042802; GO:0102480 +P0A9F3 CYSB_ECOLI HTH-type transcriptional regulator CysB (Cys regulon transcriptional activator) cysB b1275 JW1267 cysB 36,150 cysteine biosynthetic process [GO:0019344]; regulation of transcription, DNA-templated [GO:0006355]; response to X-ray [GO:0010165] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; cysteine biosynthetic process [GO:0019344]; regulation of transcription, DNA-templated [GO:0006355]; response to X-ray [GO:0010165] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003677; GO:0003700; GO:0005829; GO:0006355; GO:0010165; GO:0019344; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm. +P0A9D4 CYSE_ECOLI Serine acetyltransferase (SAT) (EC 2.3.1.30) cysE b3607 JW3582 cysE 29,317 cysteine biosynthetic process from serine [GO:0006535]; response to X-ray [GO:0010165] cysteine synthase complex [GO:0009333]; cytosol [GO:0005829] cysteine synthase complex [GO:0009333]; cytosol [GO:0005829]; serine O-acetyltransferase activity [GO:0009001]; cysteine biosynthetic process from serine [GO:0006535]; response to X-ray [GO:0010165] serine O-acetyltransferase activity [GO:0009001] GO:0005829; GO:0006535; GO:0009001; GO:0009333; GO:0010165 SUBCELLULAR LOCATION: Cytoplasm. +P0ACZ8 CUSR_ECOLI Transcriptional regulatory protein CusR cusR ylcA b0571 JW0560 ylcA cusR 25,395 phosphorelay signal transduction system [GO:0000160]; positive regulation of gene expression [GO:0010628]; regulation of transcription, DNA-templated [GO:0006355]; response to copper ion [GO:0046688] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; identical protein binding [GO:0042802]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; phosphorelay signal transduction system [GO:0000160]; positive regulation of gene expression [GO:0010628]; regulation of transcription, DNA-templated [GO:0006355]; response to copper ion [GO:0046688] DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; identical protein binding [GO:0042802]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000160; GO:0000976; GO:0001216; GO:0003677; GO:0005829; GO:0006355; GO:0010628; GO:0032993; GO:0042802; GO:0046688 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AED7 DAPE_ECOLI Succinyl-diaminopimelate desuccinylase (SDAP desuccinylase) (EC 3.5.1.18) (N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase) dapE msgB b2472 JW2456 msgB dapE 41,269 diaminopimelate biosynthetic process [GO:0019877]; FtsZ-dependent cytokinesis [GO:0043093]; lysine biosynthetic process via diaminopimelate [GO:0009089] cell division site [GO:0032153]; cytosol [GO:0005829] cell division site [GO:0032153]; cytosol [GO:0005829]; cobalt ion binding [GO:0050897]; identical protein binding [GO:0042802]; succinyl-diaminopimelate desuccinylase activity [GO:0009014]; zinc ion binding [GO:0008270]; diaminopimelate biosynthetic process [GO:0019877]; FtsZ-dependent cytokinesis [GO:0043093]; lysine biosynthetic process via diaminopimelate [GO:0009089] cobalt ion binding [GO:0050897]; identical protein binding [GO:0042802]; succinyl-diaminopimelate desuccinylase activity [GO:0009014]; zinc ion binding [GO:0008270] GO:0005829; GO:0008270; GO:0009014; GO:0009089; GO:0019877; GO:0032153; GO:0042802; GO:0043093; GO:0050897 +P0ACF4 DBHB_ECOLI DNA-binding protein HU-beta (HU-1) (NS1) hupB hopD b0440 JW0430 hopD hupB 9,226 chromosome condensation [GO:0030261]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; chromosome condensation [GO:0030261]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; identical protein binding [GO:0042802] GO:0003677; GO:0005829; GO:0006351; GO:0030261; GO:0042802 +P0ACT2 ENVR_ECOLI Probable acrEF/envCD operon repressor envR yhdK b3264 JW3232 yhdK envR 25,198 negative regulation of transcription, DNA-templated [GO:0045892]; response to drug [GO:0042493] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892]; response to drug [GO:0042493] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0042493; GO:0045892 +P0AEJ2 ENTC_ECOLI Isochorismate synthase EntC (EC 5.4.4.2) (Isochorismate mutase) entC b0593 JW0585 entC 42,932 enterobactin biosynthetic process [GO:0009239] isochorismate synthase activity [GO:0008909]; magnesium ion binding [GO:0000287]; enterobactin biosynthetic process [GO:0009239] isochorismate synthase activity [GO:0008909]; magnesium ion binding [GO:0000287] GO:0000287; GO:0008909; GO:0009239 +P52613 FLIJ_ECOLI Flagellar FliJ protein fliJ flaO flaS b1942 JW1926 flaO flaS fliJ 17,307 bacterial-type flagellum-dependent cell motility [GO:0071973]; bacterial-type flagellum organization [GO:0044781]; chemotaxis [GO:0006935]; protein transport [GO:0015031] bacterial-type flagellum [GO:0009288]; plasma membrane [GO:0005886] bacterial-type flagellum [GO:0009288]; plasma membrane [GO:0005886]; motor activity [GO:0003774]; bacterial-type flagellum organization [GO:0044781]; bacterial-type flagellum-dependent cell motility [GO:0071973]; chemotaxis [GO:0006935]; protein transport [GO:0015031] motor activity [GO:0003774] GO:0003774; GO:0005886; GO:0006935; GO:0009288; GO:0015031; GO:0044781; GO:0071973 SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. +P69380 FIEF_ECOLI Ferrous-iron efflux pump FieF fieF yiiP b3915 JW3886 yiiP fieF 32,927 cadmium ion transport [GO:0015691]; cellular cadmium ion homeostasis [GO:0006876]; cellular iron ion homeostasis [GO:0006879]; cellular zinc ion homeostasis [GO:0006882]; iron ion transport [GO:0006826]; zinc ion transport [GO:0006829] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cadmium ion transmembrane transporter activity [GO:0015086]; cation transmembrane transporter activity [GO:0008324]; ferrous iron transmembrane transporter activity [GO:0015093]; identical protein binding [GO:0042802]; zinc efflux active transmembrane transporter activity [GO:0015341]; cadmium ion transport [GO:0015691]; cellular cadmium ion homeostasis [GO:0006876]; cellular iron ion homeostasis [GO:0006879]; cellular zinc ion homeostasis [GO:0006882]; iron ion transport [GO:0006826]; zinc ion transport [GO:0006829] cadmium ion transmembrane transporter activity [GO:0015086]; cation transmembrane transporter activity [GO:0008324]; ferrous iron transmembrane transporter activity [GO:0015093]; identical protein binding [GO:0042802]; zinc efflux active transmembrane transporter activity [GO:0015341] GO:0005886; GO:0006826; GO:0006829; GO:0006876; GO:0006879; GO:0006882; GO:0008324; GO:0015086; GO:0015093; GO:0015341; GO:0015691; GO:0016020; GO:0016021; GO:0042802 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P18956 GGT_ECOLI Glutathione hydrolase proenzyme (EC 3.4.19.13) (Gamma-glutamyltranspeptidase proenzyme) (GGT) (EC 2.3.2.2) [Cleaved into: Glutathione hydrolase large chain; Glutathione hydrolase small chain] ggt b3447 JW3412 ggt 61,768 amino acid salvage [GO:0043102]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; self proteolysis [GO:0097264] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; gamma-glutamyl-peptidase activity [GO:0034722]; glutathione hydrolase activity [GO:0036374]; hypoglycin A gamma-glutamyl transpeptidase activity [GO:0102953]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]; amino acid salvage [GO:0043102]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; self proteolysis [GO:0097264] gamma-glutamyl-peptidase activity [GO:0034722]; glutathione hydrolase activity [GO:0036374]; hypoglycin A gamma-glutamyl transpeptidase activity [GO:0102953]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068] GO:0006750; GO:0006751; GO:0030288; GO:0034722; GO:0036374; GO:0042597; GO:0043102; GO:0097264; GO:0102953; GO:0103068 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:1360205, ECO:0000269|PubMed:2877974}. +P77695 GNSB_ECOLI Protein GnsB gnsB ydfY b1550 JW5253 ydfY gnsB 6,548 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P0A6S7 GPDA_ECOLI Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) gpsA b3608 JW3583 gpsA 36,362 carbohydrate metabolic process [GO:0005975]; glycerol-3-phosphate biosynthetic process [GO:0046167]; glycerol-3-phosphate catabolic process [GO:0046168]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerophospholipid biosynthetic process [GO:0046474] cytosol [GO:0005829]; glycerol-3-phosphate dehydrogenase complex [GO:0009331] cytosol [GO:0005829]; glycerol-3-phosphate dehydrogenase complex [GO:0009331]; glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952]; glycerol-3-phosphate dehydrogenase [NAD+] activity [GO:0004367]; glycerol-3-phosphate dehydrogenase [NADP+] activity [GO:0106257]; NAD binding [GO:0051287]; carbohydrate metabolic process [GO:0005975]; glycerol-3-phosphate biosynthetic process [GO:0046167]; glycerol-3-phosphate catabolic process [GO:0046168]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerophospholipid biosynthetic process [GO:0046474] glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [GO:0047952]; glycerol-3-phosphate dehydrogenase [NAD+] activity [GO:0004367]; glycerol-3-phosphate dehydrogenase [NADP+] activity [GO:0106257]; NAD binding [GO:0051287] GO:0004367; GO:0005829; GO:0005975; GO:0006072; GO:0009331; GO:0046167; GO:0046168; GO:0046474; GO:0047952; GO:0051287; GO:0106257 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00394}. +P0A9C5 GLN1B_ECOLI Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Glutamine synthetase I beta) (GSI beta) glnA b3870 JW3841 glnA 51,904 ammonia assimilation cycle [GO:0019676]; glutamine biosynthetic process [GO:0006542]; nitrogen utilization [GO:0019740]; response to radiation [GO:0009314] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; glutamate-ammonia ligase activity [GO:0004356]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ammonia assimilation cycle [GO:0019676]; glutamine biosynthetic process [GO:0006542]; nitrogen utilization [GO:0019740]; response to radiation [GO:0009314] ATP binding [GO:0005524]; glutamate-ammonia ligase activity [GO:0004356]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] GO:0004356; GO:0005524; GO:0005737; GO:0005829; GO:0006542; GO:0009314; GO:0016020; GO:0019676; GO:0019740; GO:0042802; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P9WN39}. +P0A9Z1 GLNB_ECOLI Nitrogen regulatory protein P-II 1 glnB b2553 JW2537 glnB 12,425 regulation of catalytic activity [GO:0050790]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of nitrogen utilization [GO:0006808] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; enzyme regulator activity [GO:0030234]; identical protein binding [GO:0042802]; small molecule binding [GO:0036094]; regulation of catalytic activity [GO:0050790]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of nitrogen utilization [GO:0006808] ATP binding [GO:0005524]; enzyme regulator activity [GO:0030234]; identical protein binding [GO:0042802]; small molecule binding [GO:0036094] GO:0005524; GO:0005829; GO:0006808; GO:0030234; GO:0036094; GO:0042304; GO:0042802; GO:0050790 +P0AE76 COBU_ECOLI Bifunctional adenosylcobalamin biosynthesis protein CobU (Adenosylcobinamide kinase) (EC 2.7.1.156) (Adenosylcobinamide-phosphate guanylyltransferase) (EC 2.7.7.62) cobU b1993 JW1971 cobU 20,164 cellular response to DNA damage stimulus [GO:0006974]; cobalamin biosynthetic process [GO:0009236]; porphyrin-containing compound biosynthetic process [GO:0006779] adenosylcobinamide kinase (ATP-specific) activity [GO:0036429]; adenosylcobinamide kinase (GTP-specific) activity [GO:0036428]; ATP binding [GO:0005524]; cobinamide kinase activity [GO:0008819]; cobinamide phosphate guanylyltransferase activity [GO:0008820]; GTP binding [GO:0005525]; cellular response to DNA damage stimulus [GO:0006974]; cobalamin biosynthetic process [GO:0009236]; porphyrin-containing compound biosynthetic process [GO:0006779] adenosylcobinamide kinase (ATP-specific) activity [GO:0036429]; adenosylcobinamide kinase (GTP-specific) activity [GO:0036428]; ATP binding [GO:0005524]; cobinamide kinase activity [GO:0008819]; cobinamide phosphate guanylyltransferase activity [GO:0008820]; GTP binding [GO:0005525] GO:0005524; GO:0005525; GO:0006779; GO:0006974; GO:0008819; GO:0008820; GO:0009236; GO:0036428; GO:0036429 +P46891 COF_ECOLI HMP-PP phosphatase (EC 3.6.1.-) cof b0446 JW0436 cof 30,371 antibiotic catabolic process [GO:0017001]; thiamine biosynthetic process [GO:0009228] 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity [GO:0002145]; magnesium ion binding [GO:0000287]; nucleoside-diphosphatase activity [GO:0017110]; phosphatase activity [GO:0016791]; antibiotic catabolic process [GO:0017001]; thiamine biosynthetic process [GO:0009228] 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity [GO:0002145]; magnesium ion binding [GO:0000287]; nucleoside-diphosphatase activity [GO:0017110]; phosphatase activity [GO:0016791] GO:0000287; GO:0002145; GO:0009228; GO:0016791; GO:0017001; GO:0017110 +P16703 CYSM_ECOLI Cysteine synthase B (CSase B) (EC 2.5.1.47) (O-acetylserine (thiol)-lyase B) (OAS-TL B) (O-acetylserine sulfhydrylase B) cysM b2421 JW2414 cysM 32,664 cysteine biosynthetic process from serine [GO:0006535] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; cysteine synthase activity [GO:0004124]; L-cysteine desulfhydrase activity [GO:0080146]; pyridoxal phosphate binding [GO:0030170]; cysteine biosynthetic process from serine [GO:0006535] cysteine synthase activity [GO:0004124]; L-cysteine desulfhydrase activity [GO:0080146]; pyridoxal phosphate binding [GO:0030170] GO:0004124; GO:0005737; GO:0006535; GO:0030170; GO:0080146 +P15078 CSTA_ECOLI Peptide transporter CstA (Carbon starvation protein A) cstA ybdC b0598 JW0590 ybdC cstA 75,105 cellular response to nutrient levels [GO:0031669]; cellular response to starvation [GO:0009267]; protein transport [GO:0015031] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cellular response to nutrient levels [GO:0031669]; cellular response to starvation [GO:0009267]; protein transport [GO:0015031] GO:0005886; GO:0005887; GO:0009267; GO:0015031; GO:0031669 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P67826 CUTC_ECOLI Copper homeostasis protein CutC cutC cutCM b1874 JW1863 cutCM cutC 26,762 cellular copper ion homeostasis [GO:0006878]; copper ion homeostasis [GO:0055070] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; copper ion binding [GO:0005507]; cellular copper ion homeostasis [GO:0006878]; copper ion homeostasis [GO:0055070] copper ion binding [GO:0005507] GO:0005507; GO:0005737; GO:0006878; GO:0055070 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00795, ECO:0000305}. +P18777 DMSC_ECOLI Anaerobic dimethyl sulfoxide reductase chain C (DMSO reductase anchor subunit) dmsC b0896 JW0879 dmsC 30,826 anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061] dimethyl sulfoxide reductase complex [GO:0009390]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] dimethyl sulfoxide reductase complex [GO:0009390]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; dimethyl sulfoxide reductase activity [GO:0009389]; anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061] dimethyl sulfoxide reductase activity [GO:0009389] GO:0005886; GO:0005887; GO:0009061; GO:0009389; GO:0009390; GO:0019645 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AAA3 ECPA_ECOLI Common pilus major fimbrillin subunit EcpA (MatB fimbrillin) ecpA matB yagZ b0293 JW0287 matB yagZ ecpA 20,111 pilus [GO:0009289] pilus [GO:0009289] GO:0009289 SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}. +P76540 EUTK_ECOLI Bacterial microcompartment shell protein EutK (Ethanolamine utilization protein EutK) eutK yffI b2438 JW2431 yffI eutK 17,893 ethanolamine catabolic process [GO:0046336]; response to X-ray [GO:0010165] ethanolamine degradation polyhedral organelle [GO:0031471] ethanolamine degradation polyhedral organelle [GO:0031471]; structural molecule activity [GO:0005198]; ethanolamine catabolic process [GO:0046336]; response to X-ray [GO:0010165] structural molecule activity [GO:0005198] GO:0005198; GO:0010165; GO:0031471; GO:0046336 SUBCELLULAR LOCATION: Bacterial microcompartment {ECO:0000305|PubMed:20044574}. +P0A6Q3 FABA_ECOLI 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59) (3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA) (Beta-hydroxydecanoyl thioester dehydrase) (Trans-2-decenoyl-[acyl-carrier-protein] isomerase) (EC 5.3.3.14) fabA b0954 JW0937 fabA 18,969 fatty acid biosynthetic process [GO:0006633]; lipid biosynthetic process [GO:0008610] cytosol [GO:0005829] cytosol [GO:0005829]; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity [GO:0008659]; 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity [GO:0008693]; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity [GO:0047451]; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity [GO:0004317]; trans-2-decenoyl-acyl-carrier-protein isomerase activity [GO:0034017]; fatty acid biosynthetic process [GO:0006633]; lipid biosynthetic process [GO:0008610] (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity [GO:0008659]; 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity [GO:0008693]; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity [GO:0047451]; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity [GO:0004317]; trans-2-decenoyl-acyl-carrier-protein isomerase activity [GO:0034017] GO:0004317; GO:0005829; GO:0006633; GO:0008610; GO:0008659; GO:0008693; GO:0034017; GO:0047451 SUBCELLULAR LOCATION: Cytoplasm. +P0A6S3 FLGI_ECOLI Flagellar P-ring protein (Basal body P-ring protein) flgI fla FIX flaM b1080 JW1067 fla FIX flaM flgI 38,169 bacterial-type flagellum-dependent cell motility [GO:0071973]; cellular response to DNA damage stimulus [GO:0006974] bacterial-type flagellum basal body, distal rod, P ring [GO:0009428]; outer membrane-bounded periplasmic space [GO:0030288] bacterial-type flagellum basal body, distal rod, P ring [GO:0009428]; outer membrane-bounded periplasmic space [GO:0030288]; structural molecule activity [GO:0005198]; bacterial-type flagellum-dependent cell motility [GO:0071973]; cellular response to DNA damage stimulus [GO:0006974] structural molecule activity [GO:0005198] GO:0005198; GO:0006974; GO:0009428; GO:0030288; GO:0071973 SUBCELLULAR LOCATION: Periplasm. Bacterial flagellum basal body. +P23877 FEPG_ECOLI Ferric enterobactin transport system permease protein FepG fepG b0589 JW0581 fepG 34,910 ferric-enterobactin import into cell [GO:0015685]; siderophore-dependent iron import into cell [GO:0033214] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ferric-enterobactin transmembrane transporter activity [GO:0015620]; transmembrane transporter activity [GO:0022857]; ferric-enterobactin import into cell [GO:0015685]; siderophore-dependent iron import into cell [GO:0033214] ferric-enterobactin transmembrane transporter activity [GO:0015620]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0015620; GO:0015685; GO:0022857; GO:0033214 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P75938 FLGF_ECOLI Flagellar basal-body rod protein FlgF (Putative proximal rod protein) flgF fla FVI flaX b1077 JW1064 fla FVI flaX flgF 25,912 bacterial-type flagellum-dependent cell motility [GO:0071973]; bacterial-type flagellum-dependent swarming motility [GO:0071978] bacterial-type flagellum basal body [GO:0009425]; bacterial-type flagellum hook [GO:0009424] bacterial-type flagellum basal body [GO:0009425]; bacterial-type flagellum hook [GO:0009424]; bacterial-type flagellum-dependent cell motility [GO:0071973]; bacterial-type flagellum-dependent swarming motility [GO:0071978] GO:0009424; GO:0009425; GO:0071973; GO:0071978 SUBCELLULAR LOCATION: Bacterial flagellum basal body. +P33135 FLIR_ECOLI Flagellar biosynthetic protein FliR fliR flaP b1950 JW1934 flaP fliR 28,543 bacterial-type flagellum assembly [GO:0044780]; protein targeting [GO:0006605] bacterial-type flagellum basal body [GO:0009425]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] bacterial-type flagellum basal body [GO:0009425]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; bacterial-type flagellum assembly [GO:0044780]; protein targeting [GO:0006605] GO:0005886; GO:0006605; GO:0009425; GO:0016021; GO:0044780 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. Bacterial flagellum basal body {ECO:0000269|PubMed:15919996}. +P0A998 FTNA_ECOLI Bacterial non-heme ferritin (EC 1.16.3.2) (Ferritin-1) ftnA ftn gen-165 rsgA b1905 JW1893 ftn gen-165 rsgA ftnA 19,424 cellular response to DNA damage stimulus [GO:0006974]; cellular response to iron ion [GO:0071281]; intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]; identical protein binding [GO:0042802]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to iron ion [GO:0071281]; intracellular sequestering of iron ion [GO:0006880]; iron ion transport [GO:0006826]; response to oxidative stress [GO:0006979] ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; ferroxidase activity [GO:0004322]; identical protein binding [GO:0042802] GO:0004322; GO:0005737; GO:0005829; GO:0006826; GO:0006880; GO:0006974; GO:0006979; GO:0008198; GO:0008199; GO:0042802; GO:0071281 SUBCELLULAR LOCATION: Cytoplasm. +P05042 FUMC_ECOLI Fumarate hydratase class II (Fumarase C) (EC 4.2.1.2) (Aerobic fumarase) (Iron-independent fumarase) fumC b1611 JW1603 fumC 50,489 fumarate metabolic process [GO:0006106]; malate metabolic process [GO:0006108]; response to oxidative stress [GO:0006979]; tricarboxylic acid cycle [GO:0006099] tricarboxylic acid cycle enzyme complex [GO:0045239] tricarboxylic acid cycle enzyme complex [GO:0045239]; fumarate hydratase activity [GO:0004333]; identical protein binding [GO:0042802]; fumarate metabolic process [GO:0006106]; malate metabolic process [GO:0006108]; response to oxidative stress [GO:0006979]; tricarboxylic acid cycle [GO:0006099] fumarate hydratase activity [GO:0004333]; identical protein binding [GO:0042802] GO:0004333; GO:0006099; GO:0006106; GO:0006108; GO:0006979; GO:0042802; GO:0045239 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000305}. +P37147 FXSA_ECOLI UPF0716 protein FxsA (Suppressor of F exclusion of phage T7) fxsA yjeG b4140 JW4100 yjeG fxsA 17,692 integral component of membrane [GO:0016021]; intrinsic component of plasma membrane [GO:0031226]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; intrinsic component of plasma membrane [GO:0031226]; plasma membrane [GO:0005886] GO:0005886; GO:0016021; GO:0031226 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A996 GLPC_ECOLI Anaerobic glycerol-3-phosphate dehydrogenase subunit C (G-3-P dehydrogenase) glpC b2243 JW2237 glpC 44,108 anaerobic respiration [GO:0009061]; electron transport chain [GO:0022900]; glycerol catabolic process [GO:0019563] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; 4 iron, 4 sulfur cluster binding [GO:0051539]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; anaerobic respiration [GO:0009061]; electron transport chain [GO:0022900]; glycerol catabolic process [GO:0019563] 4 iron, 4 sulfur cluster binding [GO:0051539]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872] GO:0005886; GO:0009061; GO:0019563; GO:0022900; GO:0046872; GO:0051536; GO:0051539 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase. +P36683 ACNB_ECOLI Aconitate hydratase B (ACN) (Aconitase) (EC 4.2.1.3) ((2R,3S)-2-methylisocitrate dehydratase) ((2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase) (2-methyl-cis-aconitate hydratase) (EC 4.2.1.99) (Iron-responsive protein-like) (IRP-like) (RNA-binding protein) acnB yacI yacJ b0118 JW0114 yacI yacJ acnB 93,498 glyoxylate cycle [GO:0006097]; propionate catabolic process, 2-methylcitrate cycle [GO:0019629]; regulation of translation [GO:0006417]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829] cytosol [GO:0005829]; 2-methylisocitrate dehydratase activity [GO:0047456]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; citrate dehydratase activity [GO:0047780]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; glyoxylate cycle [GO:0006097]; propionate catabolic process, 2-methylcitrate cycle [GO:0019629]; regulation of translation [GO:0006417]; tricarboxylic acid cycle [GO:0006099] 2-methylisocitrate dehydratase activity [GO:0047456]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; citrate dehydratase activity [GO:0047780]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729] GO:0003729; GO:0003730; GO:0003994; GO:0005829; GO:0006097; GO:0006099; GO:0006417; GO:0019629; GO:0046872; GO:0047456; GO:0047780; GO:0051539 +P25516 ACNA_ECOLI Aconitate hydratase A (ACN) (Aconitase) (EC 4.2.1.3) (Iron-responsive protein-like) (IRP-like) (RNA-binding protein) (Stationary phase enzyme) acnA acn b1276 JW1268 acn acnA 97,677 anaerobic respiration [GO:0009061]; citrate metabolic process [GO:0006101]; glyoxylate cycle [GO:0006097]; response to oxidative stress [GO:0006979]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; citrate dehydratase activity [GO:0047780]; iron ion binding [GO:0005506]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; anaerobic respiration [GO:0009061]; citrate metabolic process [GO:0006101]; glyoxylate cycle [GO:0006097]; response to oxidative stress [GO:0006979]; tricarboxylic acid cycle [GO:0006099] 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; citrate dehydratase activity [GO:0047780]; iron ion binding [GO:0005506]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729] GO:0003729; GO:0003730; GO:0003994; GO:0005506; GO:0005737; GO:0005829; GO:0006097; GO:0006099; GO:0006101; GO:0006979; GO:0009061; GO:0046872; GO:0047780; GO:0051539 +P06134 ADA_ECOLI Bifunctional transcriptional activator/DNA repair enzyme Ada (Regulatory protein of adaptive response) [Includes: Methylphosphotriester-DNA--protein-cysteine S-methyltransferase (EC 2.1.1.n11) (Methylphosphotriester-DNA methyltransferase); Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (O6-methylguanine-DNA alkyltransferase)] ada b2213 JW2201 ada 39,324 cellular response to DNA damage stimulus [GO:0006974]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA demethylation [GO:0080111]; negative regulation of transcription, DNA-templated [GO:0045892]; peptidyl-cysteine methylation [GO:0018125]; positive regulation of transcription, DNA-templated [GO:0045893] DNA-binding transcription factor activity [GO:0003700]; methylated-DNA-[protein]-cysteine S-methyltransferase activity [GO:0003908]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]; cellular response to DNA damage stimulus [GO:0006974]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA demethylation [GO:0080111]; negative regulation of transcription, DNA-templated [GO:0045892]; peptidyl-cysteine methylation [GO:0018125]; positive regulation of transcription, DNA-templated [GO:0045893] DNA-binding transcription factor activity [GO:0003700]; methylated-DNA-[protein]-cysteine S-methyltransferase activity [GO:0003908]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270] GO:0003700; GO:0003908; GO:0006307; GO:0006974; GO:0008270; GO:0018125; GO:0043565; GO:0045892; GO:0045893; GO:0080111 +P0AAW9 ACRZ_ECOLI Multidrug efflux pump accessory protein AcrZ (AcrAB-TolC multidrug efflux pump accessory protein AcrZ) (Acridine resistance protein Z) acrZ ybhT b0762 JW5102 ybhT acrZ 5,300 cellular response to cell envelope stress [GO:0036460]; response to antibiotic [GO:0046677]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; xenobiotic transmembrane transporter activity [GO:0042910]; cellular response to cell envelope stress [GO:0036460]; response to antibiotic [GO:0046677]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0009279; GO:0016021; GO:0036460; GO:0042910; GO:0046677; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01484, ECO:0000269|PubMed:19121005, ECO:0000269|PubMed:21778229}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01484, ECO:0000269|PubMed:19121005, ECO:0000269|PubMed:21778229}. Note=In sucrose cushions fractionates with both the inner and outer membranes. +P0A6D3 AROA_ECOLI 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) aroA b0908 JW0891 aroA 46,096 aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] cytosol [GO:0005829] cytosol [GO:0005829]; 3-phosphoshikimate 1-carboxyvinyltransferase activity [GO:0003866]; aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] 3-phosphoshikimate 1-carboxyvinyltransferase activity [GO:0003866] GO:0003866; GO:0005829; GO:0008652; GO:0009073; GO:0009423 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000305}. +P36560 ASR_ECOLI Acid shock protein asr b1597 JW5826 asr 10,591 response to zinc ion [GO:0010043] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; response to zinc ion [GO:0010043] GO:0010043; GO:0042597 SUBCELLULAR LOCATION: Periplasm. +P12996 BIOB_ECOLI Biotin synthase (EC 2.8.1.6) bioB b0775 JW0758 bioB 38,648 biotin biosynthetic process [GO:0009102] 2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; biotin synthase activity [GO:0004076]; iron ion binding [GO:0005506]; biotin biosynthetic process [GO:0009102] 2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; biotin synthase activity [GO:0004076]; iron ion binding [GO:0005506] GO:0004076; GO:0005506; GO:0009102; GO:0051537; GO:0051539 +P33927 CCMF_ECOLI Cytochrome c-type biogenesis protein CcmF ccmF yejR b2196 JW2184 yejR ccmF 71,389 cytochrome c-heme linkage [GO:0018063] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232]; cytochrome c-heme linkage [GO:0018063] heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232] GO:0005886; GO:0005887; GO:0015232; GO:0018063; GO:0020037 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77239 CUSB_ECOLI Cation efflux system protein CusB cusB ylcD b0574 JW0563 ylcD cusB 44,305 cellular copper ion homeostasis [GO:0006878]; copper ion export [GO:0060003]; detoxification of copper ion [GO:0010273]; plasma membrane copper ion transport [GO:0015679]; response to copper ion [GO:0046688]; response to silver ion [GO:0010272]; transmembrane transport [GO:0055085] cell envelope [GO:0030313]; membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288] cell envelope [GO:0030313]; membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; transition metal ion binding [GO:0046914]; transmembrane transporter activity [GO:0022857]; cellular copper ion homeostasis [GO:0006878]; copper ion export [GO:0060003]; detoxification of copper ion [GO:0010273]; plasma membrane copper ion transport [GO:0015679]; response to copper ion [GO:0046688]; response to silver ion [GO:0010272]; transmembrane transport [GO:0055085] copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; transition metal ion binding [GO:0046914]; transmembrane transporter activity [GO:0022857] GO:0005375; GO:0005507; GO:0006878; GO:0010272; GO:0010273; GO:0015679; GO:0016020; GO:0022857; GO:0030288; GO:0030313; GO:0046688; GO:0046914; GO:0055085; GO:0060003 +P77308 DDPB_ECOLI Probable D,D-dipeptide transport system permease protein DdpB ddpB yddR b1486 JW1481 yddR ddpB 37,345 protein transport [GO:0015031] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; dipeptide transmembrane transporter activity [GO:0071916]; protein transport [GO:0015031] dipeptide transmembrane transporter activity [GO:0071916] GO:0005886; GO:0005887; GO:0015031; GO:0071916 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77263 ECPE_ECOLI Probable fimbrial chaperone EcpE ecpE matF yagV b0289 JW5030 matF yagV ecpE 26,628 +P71301 ECPR_ECOLI HTH-type transcriptional regulator EcpR ecpR matA ykgK b0294 JW5031 matA ykgK ecpR 23,274 regulation of transcription, DNA-templated [GO:0006355] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677] GO:0003677; GO:0005737; GO:0006355 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0ADF6 EDD_ECOLI Phosphogluconate dehydratase (EC 4.2.1.12) (6-phosphogluconate dehydratase) (Entner-Doudoroff dehydrase) edd b1851 JW1840 edd 64,639 D-gluconate catabolic process [GO:0046177]; Entner-Doudoroff pathway through 6-phosphogluconate [GO:0009255] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; hydro-lyase activity [GO:0016836]; metal ion binding [GO:0046872]; phosphogluconate dehydratase activity [GO:0004456]; D-gluconate catabolic process [GO:0046177]; Entner-Doudoroff pathway through 6-phosphogluconate [GO:0009255] 4 iron, 4 sulfur cluster binding [GO:0051539]; hydro-lyase activity [GO:0016836]; metal ion binding [GO:0046872]; phosphogluconate dehydratase activity [GO:0004456] GO:0004456; GO:0005829; GO:0009255; GO:0016836; GO:0046177; GO:0046872; GO:0051539 +P0A6P1 EFTS_ECOLI Elongation factor Ts (EF-Ts) (Bacteriophage Q beta RNA-directed RNA polymerase subunit IV) tsf b0170 JW0165 tsf 30,423 translational elongation [GO:0006414] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; guanyl-nucleotide exchange factor activity [GO:0005085]; translation elongation factor activity [GO:0003746]; zinc ion binding [GO:0008270]; translational elongation [GO:0006414] guanyl-nucleotide exchange factor activity [GO:0005085]; translation elongation factor activity [GO:0003746]; zinc ion binding [GO:0008270] GO:0003746; GO:0005085; GO:0005737; GO:0005829; GO:0006414; GO:0008270; GO:0016020 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00050}. +P0C960 EMTA_ECOLI Endo-type membrane-bound lytic murein transglycosylase A (EC 4.2.2.n2) (Peptidoglycan lytic endotransglycosylase) emtA mltE sltZ ycgP b1193 JW5821 mltE sltZ ycgP emtA 22,227 cell wall macromolecule catabolic process [GO:0016998]; cell wall organization [GO:0071555]; peptidoglycan metabolic process [GO:0000270] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; carbon-oxygen lyase activity, acting on polysaccharides [GO:0016837]; lytic endotransglycosylase activity [GO:0008932]; lytic transglycosylase activity [GO:0008933]; cell wall macromolecule catabolic process [GO:0016998]; cell wall organization [GO:0071555]; peptidoglycan metabolic process [GO:0000270] carbon-oxygen lyase activity, acting on polysaccharides [GO:0016837]; lytic endotransglycosylase activity [GO:0008932]; lytic transglycosylase activity [GO:0008933] GO:0000270; GO:0008932; GO:0008933; GO:0009279; GO:0016837; GO:0016998; GO:0071555 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305|PubMed:9642199}; Lipid-anchor {ECO:0000305|PubMed:9642199}. +P28249 ASMA_ECOLI Protein AsmA asmA yegA b2064 JW2049 yegA asmA 68,963 regulation of protein targeting to membrane [GO:0090313] periplasmic space [GO:0042597]; plasma membrane [GO:0005886] periplasmic space [GO:0042597]; plasma membrane [GO:0005886]; regulation of protein targeting to membrane [GO:0090313] GO:0005886; GO:0042597; GO:0090313 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +Q46829 BGLA_ECOLI 6-phospho-beta-glucosidase BglA (EC 3.2.1.86) (Phospho-beta-glucosidase A) bglA bglD yqfC b2901 JW2869 bglD yqfC bglA 55,361 carbohydrate catabolic process [GO:0016052] cytosol [GO:0005829] cytosol [GO:0005829]; 6-phospho-beta-glucosidase activity [GO:0008706]; beta-glucosidase activity [GO:0008422]; glucosidase activity [GO:0015926]; methyl beta-D-glucoside 6-phosphate glucohydrolase activity [GO:0103047]; carbohydrate catabolic process [GO:0016052] 6-phospho-beta-glucosidase activity [GO:0008706]; beta-glucosidase activity [GO:0008422]; glucosidase activity [GO:0015926]; methyl beta-D-glucoside 6-phosphate glucohydrolase activity [GO:0103047] GO:0005829; GO:0008422; GO:0008706; GO:0015926; GO:0016052; GO:0103047 +P07862 DDLB_ECOLI D-alanine--D-alanine ligase B (EC 6.3.2.4) (D-Ala-D-Ala ligase B) (D-alanylalanine synthetase B) ddlB ddl b0092 JW0090 ddl ddlB 32,840 cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; D-alanine-D-alanine ligase activity [GO:0008716]; metal ion binding [GO:0046872]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] ATP binding [GO:0005524]; D-alanine-D-alanine ligase activity [GO:0008716]; metal ion binding [GO:0046872] GO:0005524; GO:0005829; GO:0008360; GO:0008716; GO:0009252; GO:0046872; GO:0071555 SUBCELLULAR LOCATION: Cytoplasm. +P77622 DDPF_ECOLI Probable D,D-dipeptide transport ATP-binding protein DdpF ddpF yddO b1483 JW1478 yddO ddpF 34,621 protein transport [GO:0015031] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; protein transport [GO:0015031] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0015031; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P0AEC8 DCUS_ECOLI Sensor histidine kinase DcuS (EC 2.7.13.3) (Fumarate sensor) dcuS yjdH b4125 JW4086 yjdH dcuS 60,551 phosphorelay signal transduction system [GO:0000160]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; protein histidine kinase complex [GO:0009365] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; protein histidine kinase complex [GO:0009365]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673]; phosphorelay signal transduction system [GO:0000160]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphorelay sensor kinase activity [GO:0000155]; protein histidine kinase activity [GO:0004673] GO:0000155; GO:0000160; GO:0004673; GO:0005524; GO:0005829; GO:0005886; GO:0005887; GO:0006355; GO:0006468; GO:0007165; GO:0009365; GO:0016021; GO:0030288; GO:0042802; GO:0046777 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AEF8 DPPB_ECOLI Dipeptide transport system permease protein DppB dppB b3543 JW3512 dppB 37,497 protein transport [GO:0015031] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; dipeptide transmembrane transporter activity [GO:0071916]; protein transport [GO:0015031] dipeptide transmembrane transporter activity [GO:0071916] GO:0005886; GO:0015031; GO:0016021; GO:0071916 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P0AAG0 DPPD_ECOLI Dipeptide transport ATP-binding protein DppD (EC 7.4.2.9) dppD b3541 JW3510 dppD 35,844 protein transport [GO:0015031] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; heme transmembrane transporter activity [GO:0015232]; protein transport [GO:0015031] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; heme transmembrane transporter activity [GO:0015232] GO:0005524; GO:0005886; GO:0015031; GO:0015232; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P31545 EFEB_ECOLI Deferrochelatase/peroxidase EfeB (EC 1.11.1.-) efeB ycdB b1019 JW1004 ycdB efeB 46,754 cellular response to DNA damage stimulus [GO:0006974]; iron import into cell [GO:0033212] cytosol [GO:0005829]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] cytosol [GO:0005829]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]; cellular response to DNA damage stimulus [GO:0006974]; iron import into cell [GO:0033212] heme binding [GO:0020037]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601] GO:0004601; GO:0005829; GO:0006974; GO:0020037; GO:0030288; GO:0033212; GO:0042597; GO:0046872 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:16551627}. +P75857 ELFC_ECOLI Probable outer membrane usher protein ElfC elfC ycbS b0940 JW0923 ycbS elfC 95,242 pilus assembly [GO:0009297]; pilus organization [GO:0043711] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; fimbrial usher porin activity [GO:0015473]; heparin binding [GO:0008201]; pilus assembly [GO:0009297]; pilus organization [GO:0043711] fimbrial usher porin activity [GO:0015473]; heparin binding [GO:0008201] GO:0008201; GO:0009279; GO:0009297; GO:0015473; GO:0016021; GO:0043711 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. +P0A8Y8 ENTH_ECOLI Proofreading thioesterase EntH (EC 3.1.2.-) (Enterobactin synthase component H) (p15) entH ybdB b0597 JW0589 ybdB entH 14,970 enterobactin biosynthetic process [GO:0009239] cytosol [GO:0005829] cytosol [GO:0005829]; 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity [GO:0061522]; CoA hydrolase activity [GO:0016289]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]; thiolester hydrolase activity [GO:0016790]; enterobactin biosynthetic process [GO:0009239] 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity [GO:0061522]; CoA hydrolase activity [GO:0016289]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]; thiolester hydrolase activity [GO:0016790] GO:0005829; GO:0009239; GO:0016289; GO:0016788; GO:0016790; GO:0042802; GO:0061522 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00907, ECO:0000269|PubMed:17675380}. +P04995 EX1_ECOLI Exodeoxyribonuclease I (ExoI) (Exonuclease I) (EC 3.1.11.1) (DNA deoxyribophosphodiesterase) (dRPase) sbcB cpeA xonA b2011 JW1993 cpeA xonA sbcB 54,501 DNA catabolic process [GO:0006308]; DNA catabolic process, exonucleolytic [GO:0000738]; DNA repair [GO:0006281] 3'-5'-exoribonuclease activity [GO:0000175]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; exodeoxyribonuclease I activity [GO:0008852]; magnesium ion binding [GO:0000287]; single-stranded DNA 3'-5' exodeoxyribonuclease activity [GO:0008310]; single-stranded DNA binding [GO:0003697]; DNA catabolic process [GO:0006308]; DNA catabolic process, exonucleolytic [GO:0000738]; DNA repair [GO:0006281] 3'-5'-exoribonuclease activity [GO:0000175]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; exodeoxyribonuclease I activity [GO:0008852]; magnesium ion binding [GO:0000287]; single-stranded DNA 3'-5' exodeoxyribonuclease activity [GO:0008310]; single-stranded DNA binding [GO:0003697] GO:0000175; GO:0000287; GO:0000738; GO:0003697; GO:0006281; GO:0006308; GO:0008310; GO:0008852; GO:0051575 +P0ABV2 EXBD_ECOLI Biopolymer transport protein ExbD exbD b3005 JW2973 exbD 15,527 bacteriocin transport [GO:0043213]; protein stabilization [GO:0050821]; protein transport [GO:0015031] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; energy transducer activity [GO:0031992]; identical protein binding [GO:0042802]; transmembrane transporter activity [GO:0022857]; bacteriocin transport [GO:0043213]; protein stabilization [GO:0050821]; protein transport [GO:0015031] energy transducer activity [GO:0031992]; identical protein binding [GO:0042802]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0015031; GO:0022857; GO:0031992; GO:0042802; GO:0043213; GO:0050821; GO:0098797 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass type II membrane protein. +P0AA78 EXUT_ECOLI Hexuronate transporter exuT b3093 JW3064 exuT 46,892 hexuronate transmembrane transport [GO:0015736] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; hexuronate transmembrane transporter activity [GO:0015134]; hexuronate transmembrane transport [GO:0015736] hexuronate transmembrane transporter activity [GO:0015134] GO:0005886; GO:0015134; GO:0015736; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AEM0 FKBX_ECOLI FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Rotamase) fkpB slpA yaaD b0028 JW0026 slpA yaaD fkpB 16,081 chaperone-mediated protein folding [GO:0061077] cytosol [GO:0005829] cytosol [GO:0005829]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; chaperone-mediated protein folding [GO:0061077] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] GO:0003755; GO:0005829; GO:0061077 +P04949 FLIC_ECOLI Flagellin fliC flaF hag b1923 JW1908 flaF hag fliC 51,295 bacterial-type flagellum [GO:0009288]; extracellular region [GO:0005576] bacterial-type flagellum [GO:0009288]; extracellular region [GO:0005576]; structural molecule activity [GO:0005198] structural molecule activity [GO:0005198] GO:0005198; GO:0005576; GO:0009288 SUBCELLULAR LOCATION: Secreted. Bacterial flagellum. +P0A8Q0 FRDC_ECOLI Fumarate reductase subunit C (Fumarate reductase 15 kDa hydrophobic protein) (Quinol-fumarate reductase subunit C) (QFR subunit C) frdC b4152 JW4113 frdC 15,015 anaerobic respiration [GO:0009061]; bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973]; fermentation [GO:0006113] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; plasma membrane fumarate reductase complex [GO:0045284] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; plasma membrane fumarate reductase complex [GO:0045284]; fumarate reductase (menaquinone) [GO:0102040]; succinate dehydrogenase activity [GO:0000104]; anaerobic respiration [GO:0009061]; bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973]; fermentation [GO:0006113] fumarate reductase (menaquinone) [GO:0102040]; succinate dehydrogenase activity [GO:0000104] GO:0000104; GO:0005886; GO:0006113; GO:0009061; GO:0016021; GO:0044780; GO:0045284; GO:0071973; GO:0102040 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00708, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00708, ECO:0000269|PubMed:10373108}. +P0AAI3 FTSH_ECOLI ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-) (Cell division protease FtsH) ftsH hflB mrsC std tolZ b3178 JW3145 hflB mrsC std tolZ ftsH 70,708 protein catabolic process [GO:0030163]; proteolysis [GO:0006508] integral component of plasma membrane [GO:0005887]; membrane protein complex [GO:0098796]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane protein complex [GO:0098796]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP-dependent peptidase activity [GO:0004176]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508] ATP binding [GO:0005524]; ATP-dependent peptidase activity [GO:0004176]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270] GO:0004176; GO:0004222; GO:0005524; GO:0005886; GO:0005887; GO:0006508; GO:0008270; GO:0030163; GO:0098796 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01458, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:8444797, ECO:0000269|PubMed:8947034}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01458, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:8444797, ECO:0000269|PubMed:8947034}. +P0ABG4 FTSW_ECOLI Probable peptidoglycan glycosyltransferase FtsW (PGT) (EC 2.4.1.129) (Cell division protein FtsW) (Cell wall polymerase) (Lipid II flippase FtsW) (Peptidoglycan polymerase) (PG polymerase) ftsW b0089 JW0087 ftsW 45,987 cell division [GO:0051301]; cell wall organization [GO:0071555]; FtsZ-dependent cytokinesis [GO:0043093]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] cell division site [GO:0032153]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cell division site [GO:0032153]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; lipid-linked peptidoglycan transporter activity [GO:0015648]; peptidoglycan glycosyltransferase activity [GO:0008955]; cell division [GO:0051301]; cell wall organization [GO:0071555]; FtsZ-dependent cytokinesis [GO:0043093]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] lipid-linked peptidoglycan transporter activity [GO:0015648]; peptidoglycan glycosyltransferase activity [GO:0008955] GO:0005886; GO:0005887; GO:0008360; GO:0008955; GO:0009252; GO:0015648; GO:0032153; GO:0043093; GO:0051301; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00913, ECO:0000269|PubMed:11807049, ECO:0000269|PubMed:12423747, ECO:0000269|PubMed:9603865}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00913, ECO:0000269|PubMed:11807049, ECO:0000269|PubMed:12423747, ECO:0000269|PubMed:9603865}. Note=Localizes to the division septum. Localization requires FtsZ, FtsA, FtsQ and FtsL, but not FtsI. +P0AEN4 FTSL_ECOLI Cell division protein FtsL ftsL mraR yabD b0083 JW0081 mraR yabD ftsL 13,627 FtsZ-dependent cytokinesis [GO:0043093] cell division site [GO:0032153]; integral component of plasma membrane [GO:0005887] cell division site [GO:0032153]; integral component of plasma membrane [GO:0005887]; FtsZ-dependent cytokinesis [GO:0043093] GO:0005887; GO:0032153; GO:0043093 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00910, ECO:0000269|PubMed:10027987, ECO:0000269|PubMed:11703663, ECO:0000269|PubMed:11948172, ECO:0000269|PubMed:1332942, ECO:0000269|PubMed:15165235}; Single-pass type II membrane protein {ECO:0000255|HAMAP-Rule:MF_00910, ECO:0000269|PubMed:10027987, ECO:0000269|PubMed:11703663, ECO:0000269|PubMed:11948172, ECO:0000269|PubMed:1332942, ECO:0000269|PubMed:15165235}. Note=Localizes to the division septum where it forms a ring structure. Localization requires FtsZ, FtsA, ZipA, FtsK, FtsQ and FtsB, but not FtsI and FtsN. Localization of FtsB and FtsL is codependent. +P37338 GLAR_ECOLI HTH-type transcriptional repressor GlaR (Carbon starvation induced regulator) (GlaH operon repressor) glaR csiR gabC ygaE b2664 JW2639 csiR gabC ygaE glaR 24,991 negative regulation of DNA-templated transcription, initiation [GO:2000143]; regulation of transcription, DNA-templated [GO:0006355] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of DNA-templated transcription, initiation [GO:2000143]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0005737; GO:0006355; GO:2000143 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P09391 GLPG_ECOLI Rhomboid protease GlpG (EC 3.4.21.105) (Intramembrane serine protease) glpG b3424 JW5687 glpG 31,307 proteolysis [GO:0006508] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508] endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252] GO:0004175; GO:0004252; GO:0005886; GO:0005887; GO:0006508; GO:0042802 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16216077}; Multi-pass membrane protein {ECO:0000269|PubMed:16216077}. +P77555 ALLD_ECOLI Ureidoglycolate dehydrogenase (NAD(+)) (EC 1.1.1.350) allD glxB8 ylbC b0517 JW0505 glxB8 ylbC allD 37,967 allantoin assimilation pathway [GO:0009442]; purine nucleobase metabolic process [GO:0006144] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ureidoglycolate dehydrogenase activity [GO:0009040]; allantoin assimilation pathway [GO:0009442]; purine nucleobase metabolic process [GO:0006144] ureidoglycolate dehydrogenase activity [GO:0009040] GO:0005737; GO:0006144; GO:0009040; GO:0009442 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0ACR0 ALLS_ECOLI HTH-type transcriptional activator AllS allS glxA1 ybbS b0504 JW0492 glxA1 ybbS allS 34,512 positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0006355; GO:0043565; GO:0045893 +P32720 ALSC_ECOLI D-allose transport system permease protein AlsC alsC yjcV b4086 JW4047 yjcV alsC 34,316 carbohydrate transport [GO:0008643] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; carbohydrate transport [GO:0008643] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0008643; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P00888 AROF_ECOLI Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive (EC 2.5.1.54) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) (DAHP synthase) (Phospho-2-keto-3-deoxyheptonate aldolase) aroF b2601 JW2582 aroF 38,804 aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 3-deoxy-7-phosphoheptulonate synthase activity [GO:0003849]; identical protein binding [GO:0042802]; aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423] 3-deoxy-7-phosphoheptulonate synthase activity [GO:0003849]; identical protein binding [GO:0042802] GO:0003849; GO:0005737; GO:0008652; GO:0009073; GO:0009423; GO:0042802 +P26612 AMY2_ECOLI Cytoplasmic alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase) amyA yedC b1927 JW1912 yedC amyA 56,639 carbohydrate metabolic process [GO:0005975] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; alpha-amylase activity [GO:0004556]; alpha-amylase activity (releasing maltohexaose) [GO:0103025]; calcium ion binding [GO:0005509]; carbohydrate metabolic process [GO:0005975] alpha-amylase activity [GO:0004556]; alpha-amylase activity (releasing maltohexaose) [GO:0103025]; calcium ion binding [GO:0005509] GO:0004556; GO:0005509; GO:0005737; GO:0005975; GO:0103025 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1400215}. +P25549 ASLA_ECOLI Putative sulfatase AslA (EC 3.1.6.-) aslA atsA b3801 JW3773 atsA aslA 60,718 periplasmic space [GO:0042597] periplasmic space [GO:0042597]; arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872] GO:0004065; GO:0042597; GO:0046872 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P75733 CHIP_ECOLI Chitoporin (ChiP-III) chiP ybfM b0681 JW0667 ybfM chiP 52,780 diacetylchitobiose metabolic process [GO:0052778]; oligosaccharide transport [GO:0015772]; polysaccharide transport [GO:0015774] cell outer membrane [GO:0009279]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; pore complex [GO:0046930]; channel activity [GO:0015267]; porin activity [GO:0015288]; diacetylchitobiose metabolic process [GO:0052778]; oligosaccharide transport [GO:0015772]; polysaccharide transport [GO:0015774] channel activity [GO:0015267]; porin activity [GO:0015288] GO:0009279; GO:0015267; GO:0015288; GO:0015772; GO:0015774; GO:0046930; GO:0052778 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305|PubMed:12192075}; Multi-pass membrane protein {ECO:0000305|PubMed:12192075}. +P21169 DCOR_ECOLI Constitutive ornithine decarboxylase (EC 4.1.1.17) speC b2965 JW5482 speC 79,416 putrescine biosynthetic process from ornithine [GO:0033387]; spermidine biosynthetic process [GO:0008295] cytosol [GO:0005829] cytosol [GO:0005829]; carboxy-lyase activity [GO:0016831]; ornithine decarboxylase activity [GO:0004586]; pyridoxal phosphate binding [GO:0030170]; putrescine biosynthetic process from ornithine [GO:0033387]; spermidine biosynthetic process [GO:0008295] carboxy-lyase activity [GO:0016831]; ornithine decarboxylase activity [GO:0004586]; pyridoxal phosphate binding [GO:0030170] GO:0004586; GO:0005829; GO:0008295; GO:0016831; GO:0030170; GO:0033387 +P0AFR2 DAUA_ECOLI C4-dicarboxylic acid transporter DauA (Dicarboxylic acid uptake system A) dauA ychM b1206 JW5189 ychM dauA 59,429 aspartate transmembrane transport [GO:0015810]; fumarate transport [GO:0015741]; succinate transmembrane transport [GO:0071422] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; fumarate transmembrane transporter activity [GO:0015138]; L-aspartate transmembrane transporter activity [GO:0015183]; secondary active sulfate transmembrane transporter activity [GO:0008271]; succinate transmembrane transporter activity [GO:0015141]; aspartate transmembrane transport [GO:0015810]; fumarate transport [GO:0015741]; succinate transmembrane transport [GO:0071422] fumarate transmembrane transporter activity [GO:0015138]; L-aspartate transmembrane transporter activity [GO:0015183]; secondary active sulfate transmembrane transporter activity [GO:0008271]; succinate transmembrane transporter activity [GO:0015141] GO:0005886; GO:0008271; GO:0015138; GO:0015141; GO:0015183; GO:0015741; GO:0015810; GO:0016021; GO:0071422 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:23278959}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:23278959}. +P21693 DBPA_ECOLI ATP-dependent RNA helicase DbpA (EC 3.6.4.13) dbpA b1343 JW1337 dbpA 49,188 ribosomal large subunit assembly [GO:0000027] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 3'-5' RNA helicase activity [GO:0034458]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; DNA/RNA helicase activity [GO:0033677]; RNA helicase activity [GO:0003724]; rRNA binding [GO:0019843]; ribosomal large subunit assembly [GO:0000027] 3'-5' RNA helicase activity [GO:0034458]; ADP binding [GO:0043531]; ATPase activity [GO:0016887]; ATP binding [GO:0005524]; DNA/RNA helicase activity [GO:0033677]; RNA helicase activity [GO:0003724]; rRNA binding [GO:0019843] GO:0000027; GO:0003724; GO:0005524; GO:0005737; GO:0016887; GO:0019843; GO:0033677; GO:0034458; GO:0043531 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P76016 DHAR_ECOLI PTS-dependent dihydroxyacetone kinase operon regulatory protein dhaR ycgU b1201 JW5188 ycgU dhaR 70,562 glycerol metabolic process [GO:0006071]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] ATP binding [GO:0005524]; sequence-specific DNA binding [GO:0043565]; transcription factor binding [GO:0008134]; glycerol metabolic process [GO:0006071]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] ATP binding [GO:0005524]; sequence-specific DNA binding [GO:0043565]; transcription factor binding [GO:0008134] GO:0005524; GO:0006071; GO:0006351; GO:0006355; GO:0008134; GO:0043565 +P36943 EAEH_ECOLI Putative attaching and effacing protein homolog eaeH b0297 JW0291 eaeH 33,175 cell adhesion [GO:0007155]; pathogenesis [GO:0009405] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; cell adhesion [GO:0007155]; pathogenesis [GO:0009405] GO:0007155; GO:0009279; GO:0009405 +P45763 GSPL_ECOLI Putative type II secretion system protein L (T2SS protein L) (Putative general secretion pathway protein L) gspL yheK b3333 JW5705 yheK gspL 44,540 protein secretion by the type II secretion system [GO:0015628] Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627] Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627]; protein secretion by the type II secretion system [GO:0015628] GO:0005886; GO:0009276; GO:0015627; GO:0015628; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:P25060}; Single-pass membrane protein {ECO:0000250|UniProtKB:P25060}. +P41442 GSPG_ECOLI Type II secretion system core protein G (T2SS core protein G) (Protein transport protein HofG) (Putative general secretion pathway protein G) gspG hofG hopG b3328 JW3290 hofG hopG gspG 15,905 protein secretion by the type II secretion system [GO:0015628] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627]; protein secretion by the type II secretion system [GO:0015628] GO:0005886; GO:0015627; GO:0015628; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:Q00514}; Single-pass membrane protein {ECO:0000255}. +P75799 GSID_ECOLI Glutathione transport system permease protein GsiD gsiD yliD b0832 JW0816 yliD gsiD 33,238 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; dipeptide transmembrane transporter activity [GO:0071916] dipeptide transmembrane transporter activity [GO:0071916] GO:0005886; GO:0005887; GO:0071916 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P37127 AEGA_ECOLI Putative oxidoreductase AegA (Anaerobically expressed gene A) aegA yffG b2468 JW2452 yffG aegA 71,844 urate catabolic process [GO:0019628] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; urate catabolic process [GO:0019628] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] GO:0016491; GO:0019628; GO:0046872; GO:0051539 +P0A9E0 ARAC_ECOLI Arabinose operon regulatory protein (HTH-type transcriptional regulator AraC) araC b0064 JW0063 araC 33,384 arabinose catabolic process [GO:0019568] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; arabinose catabolic process [GO:0019568] DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0001217; GO:0005829; GO:0019568; GO:0032993; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P08203 ARAD_ECOLI L-ribulose-5-phosphate 4-epimerase AraD (EC 5.1.3.4) (Phosphoribulose isomerase) araD b0061 JW0060 araD 25,519 L-arabinose catabolic process to xylulose 5-phosphate [GO:0019569]; L-lyxose metabolic process [GO:0019324]; pentose catabolic process [GO:0019323]; protein homotetramerization [GO:0051289] cytosol [GO:0005829] cytosol [GO:0005829]; aldehyde-lyase activity [GO:0016832]; L-ribulose-phosphate 4-epimerase activity [GO:0008742]; zinc ion binding [GO:0008270]; L-arabinose catabolic process to xylulose 5-phosphate [GO:0019569]; L-lyxose metabolic process [GO:0019324]; pentose catabolic process [GO:0019323]; protein homotetramerization [GO:0051289] aldehyde-lyase activity [GO:0016832]; L-ribulose-phosphate 4-epimerase activity [GO:0008742]; zinc ion binding [GO:0008270] GO:0005829; GO:0008270; GO:0008742; GO:0016832; GO:0019323; GO:0019324; GO:0019569; GO:0051289 +P61517 CAN_ECOLI Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase 2) can cynT2 yadF b0126 JW0122 cynT2 yadF can 25,097 carbon utilization [GO:0015976] cytosol [GO:0005829] cytosol [GO:0005829]; carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]; carbon utilization [GO:0015976] carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270] GO:0004089; GO:0005829; GO:0008270; GO:0015976 +P0AE78 CORC_ECOLI Magnesium and cobalt efflux protein CorC corC ybeX b0658 JW0655 ybeX corC 33,298 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; flavin adenine dinucleotide binding [GO:0050660] flavin adenine dinucleotide binding [GO:0050660] GO:0005886; GO:0050660 +P00816 CYNS_ECOLI Cyanate hydratase (Cyanase) (EC 4.2.1.104) (Cyanate hydrolase) (Cyanate lyase) cynS cnt b0340 JW0331 cnt cynS 17,049 cyanate catabolic process [GO:0009440] cyanate hydratase activity [GO:0008824]; DNA binding [GO:0003677]; cyanate catabolic process [GO:0009440] cyanate hydratase activity [GO:0008824]; DNA binding [GO:0003677] GO:0003677; GO:0008824; GO:0009440 +P77790 DDPX_ECOLI D-alanyl-D-alanine dipeptidase (D-Ala-D-Ala dipeptidase) (EC 3.4.13.22) ddpX vanX yddT b1488 JW1483 vanX yddT ddpX 21,213 cell wall organization [GO:0071555]; response to starvation [GO:0042594] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; dipeptidase activity [GO:0016805]; zinc D-Ala-D-Ala carboxypeptidase activity [GO:0009046]; zinc ion binding [GO:0008270]; cell wall organization [GO:0071555]; response to starvation [GO:0042594] dipeptidase activity [GO:0016805]; zinc D-Ala-D-Ala carboxypeptidase activity [GO:0009046]; zinc ion binding [GO:0008270] GO:0005737; GO:0008270; GO:0009046; GO:0016805; GO:0042594; GO:0071555 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:9751644}. +P0A6K6 DEOB_ECOLI Phosphopentomutase (EC 5.4.2.7) (Phosphodeoxyribomutase) deoB drm thyR b4383 JW4346 drm thyR deoB 44,370 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; cellular metabolic compound salvage [GO:0043094]; cellular response to DNA damage stimulus [GO:0006974]; deoxyribonucleotide catabolic process [GO:0009264] cytosol [GO:0005829] cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; phosphopentomutase activity [GO:0008973]; 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; cellular metabolic compound salvage [GO:0043094]; cellular response to DNA damage stimulus [GO:0006974]; deoxyribonucleotide catabolic process [GO:0009264] magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; phosphopentomutase activity [GO:0008973] GO:0000287; GO:0005829; GO:0006015; GO:0006974; GO:0008973; GO:0009264; GO:0030145; GO:0043094 SUBCELLULAR LOCATION: Cytoplasm. +P0A6J5 DADA_ECOLI D-amino acid dehydrogenase (EC 1.4.99.-) (D-alanine dehydrogenase) dadA dadR b1189 JW1178 dadR dadA 47,607 D-alanine catabolic process [GO:0055130]; L-alanine oxidation to pyruvate via D-alanine [GO:0019480] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; D-amino-acid dehydrogenase activity [GO:0008718]; oxidoreductase activity [GO:0016491]; D-alanine catabolic process [GO:0055130]; L-alanine oxidation to pyruvate via D-alanine [GO:0019480] D-amino-acid dehydrogenase activity [GO:0008718]; oxidoreductase activity [GO:0016491] GO:0005737; GO:0005886; GO:0008718; GO:0016491; GO:0019480; GO:0055130 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:13292, ECO:0000269|PubMed:15358424}; Peripheral membrane protein {ECO:0000269|PubMed:13292, ECO:0000269|PubMed:15358424}. +P0AEJ6 EUTB_ECOLI Ethanolamine ammonia-lyase large subunit (EAL large subunit) (EC 4.3.1.7) (Ethanolamine ammonia-lyase alpha subunit) (Ethanolamine ammonia-lyase heavy chain) (Ethanolamine deaminase large subunit) eutB b2441 JW2434 eutB 49,403 cellular amino acid metabolic process [GO:0006520]; ethanolamine catabolic process [GO:0046336] cytosol [GO:0005829]; ethanolamine ammonia-lyase complex [GO:0009350] cytosol [GO:0005829]; ethanolamine ammonia-lyase complex [GO:0009350]; ethanolamine ammonia-lyase activity [GO:0008851]; cellular amino acid metabolic process [GO:0006520]; ethanolamine catabolic process [GO:0046336] ethanolamine ammonia-lyase activity [GO:0008851] GO:0005829; GO:0006520; GO:0008851; GO:0009350; GO:0046336 SUBCELLULAR LOCATION: Bacterial microcompartment {ECO:0000255|HAMAP-Rule:MF_00861}. +P45523 FKBA_ECOLI FKBP-type peptidyl-prolyl cis-trans isomerase FkpA (PPIase) (EC 5.2.1.8) (Rotamase) fkpA yzzS b3347 JW3309 yzzS fkpA 28,882 protein refolding [GO:0042026] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein refolding [GO:0042026] peptidyl-prolyl cis-trans isomerase activity [GO:0003755] GO:0003755; GO:0030288; GO:0042026 SUBCELLULAR LOCATION: Periplasm. +P31068 FLIH_ECOLI Flagellar assembly protein FliH fliH fla AII.3 fla BIII b1940 JW1924 fla AII.3 fla BIII fliH 25,050 bacterial-type flagellum-dependent cell motility [GO:0071973]; bacterial-type flagellum organization [GO:0044781]; protein transport [GO:0015031] bacterial-type flagellum [GO:0009288]; cytosol [GO:0005829] bacterial-type flagellum [GO:0009288]; cytosol [GO:0005829]; motor activity [GO:0003774]; bacterial-type flagellum organization [GO:0044781]; bacterial-type flagellum-dependent cell motility [GO:0071973]; protein transport [GO:0015031] motor activity [GO:0003774] GO:0003774; GO:0005829; GO:0009288; GO:0015031; GO:0044781; GO:0071973 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P06971 FHUA_ECOLI Ferrichrome outer membrane transporter/phage receptor (Ferric hydroxamate receptor) (Ferric hydroxamate uptake) (Ferrichrome-iron receptor) fhuA tonA b0150 JW0146 tonA fhuA 82,182 iron ion homeostasis [GO:0055072] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; iron ion binding [GO:0005506]; protein domain specific binding [GO:0019904]; siderophore uptake transmembrane transporter activity [GO:0015344]; signaling receptor activity [GO:0038023]; toxic substance binding [GO:0015643]; virion binding [GO:0046790]; iron ion homeostasis [GO:0055072] iron ion binding [GO:0005506]; protein domain specific binding [GO:0019904]; siderophore uptake transmembrane transporter activity [GO:0015344]; signaling receptor activity [GO:0038023]; toxic substance binding [GO:0015643]; virion binding [GO:0046790] GO:0005506; GO:0009279; GO:0015344; GO:0015643; GO:0016021; GO:0019904; GO:0038023; GO:0046790; GO:0055072 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:2066336, ECO:0000269|PubMed:8916906, ECO:0000269|PubMed:9856937, ECO:0000269|PubMed:9865695}; Multi-pass membrane protein {ECO:0000269|PubMed:9856937, ECO:0000269|PubMed:9865695}. +P0ADH7 FIME_ECOLI Type 1 fimbriae regulatory protein FimE fimE b4313 JW4276 fimE 23,116 DNA integration [GO:0015074]; DNA recombination [GO:0006310] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074 +P45541 FRLC_ECOLI Fructoselysine 3-epimerase (EC 5.1.3.41) frlC yhfO yhfP b4474 JW5699 yhfO yhfP frlC 31,169 amino sugar catabolic process [GO:0046348] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]; amino sugar catabolic process [GO:0046348] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857] GO:0016857; GO:0042802; GO:0046348; GO:0046872 +P0AEQ1 GLCG_ECOLI Protein GlcG glcG yghC b2977 JW2944 yghC glcG 13,737 +P75884 GFCB_ECOLI Uncharacterized lipoprotein GfcB (Group 4 capsule protein B homolog) gfcB ymcC b0986 JW0969 ymcC gfcB 24,268 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P32721 ALSA_ECOLI D-allose import ATP-binding protein AlsA (EC 7.5.2.8) alsA yjcW b4087 JW4048 yjcW alsA 56,745 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ABC-type D-ribose transporter activity [GO:0015611]; ATP binding [GO:0005524] ABC-type D-ribose transporter activity [GO:0015611]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0015611 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. +P50466 AER_ECOLI Aerotaxis receptor aer air yqjJ b3072 JW3043 air yqjJ aer 55,066 chemotaxis [GO:0006935]; positive aerotaxis [GO:0052131]; signal transduction [GO:0007165] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888]; chemotaxis [GO:0006935]; positive aerotaxis [GO:0052131]; signal transduction [GO:0007165] identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888] GO:0004888; GO:0005886; GO:0005887; GO:0006935; GO:0007165; GO:0042802; GO:0052131 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:22380631}; Multi-pass membrane protein {ECO:0000269|PubMed:22380631}. Note=Predominantly localized to one cell pole in mid-to-late exponential phase, with a few smaller foci elsewhere in the cell. +P25550 ASLB_ECOLI Anaerobic sulfatase-maturating enzyme homolog AslB (AnSME homolog) aslB atsB b3800 JW5594 atsB aslB 46,513 protein maturation [GO:0051604] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; protein maturation [GO:0051604] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] GO:0016491; GO:0046872; GO:0051539; GO:0051604 +P0AE52 BCP_ECOLI Peroxiredoxin Bcp (EC 1.11.1.24) (Bacterioferritin comigratory protein) (Thioredoxin peroxidase) (Thioredoxin-dependent peroxiredoxin Bcp) bcp b2480 JW2465 bcp 17,634 cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; hydroperoxide reductase activity [GO:0032843]; thioredoxin peroxidase activity [GO:0008379]; cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; response to oxidative stress [GO:0006979] hydroperoxide reductase activity [GO:0032843]; thioredoxin peroxidase activity [GO:0008379] GO:0005737; GO:0005829; GO:0006979; GO:0008379; GO:0032843; GO:0034599; GO:0045454 +P77330 BORD_ECOLI Prophage lipoprotein Bor homolog (Lipoprotein Bor homolog from lambdoid prophage DLP12) borD ybcU b0557 JW0546 ybcU borD 10,447 cellular response to magnesium ion [GO:0071286] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; cellular response to magnesium ion [GO:0071286] GO:0005886; GO:0071286 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +Q46897 CAS6_ECOLI CRISPR system Cascade subunit CasE (EC 3.1.-.-) (CasE endoRNase) (crRNA endonuclease) casE cas6e ygcH b2756 JW2726 cas6e ygcH casE 22,293 defense response to virus [GO:0051607]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]; RNA processing [GO:0006396] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; endoribonuclease activity [GO:0004521]; RNA binding [GO:0003723]; defense response to virus [GO:0051607]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]; RNA processing [GO:0006396] endoribonuclease activity [GO:0004521]; RNA binding [GO:0003723] GO:0003723; GO:0004521; GO:0006396; GO:0032991; GO:0051607; GO:0090502 +P0AE88 CPXR_ECOLI Transcriptional regulatory protein CpxR cpxR yiiA b3912 JW3883 yiiA cpxR 26,312 cell adhesion [GO:0007155]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cell-substrate adhesion [GO:0010810] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; cell adhesion [GO:0007155]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cell-substrate adhesion [GO:0010810] DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000976; GO:0001216; GO:0003700; GO:0005829; GO:0007155; GO:0010810; GO:0032993; GO:0045892; GO:0045893 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A6K1 DAPF_ECOLI Diaminopimelate epimerase (DAP epimerase) (EC 5.1.1.7) (PLP-independent amino acid racemase) dapF b3809 JW5592 dapF 30,209 lysine biosynthetic process via diaminopimelate [GO:0009089] cytosol [GO:0005829] cytosol [GO:0005829]; diaminopimelate epimerase activity [GO:0008837]; lysine biosynthetic process via diaminopimelate [GO:0009089] diaminopimelate epimerase activity [GO:0008837] GO:0005829; GO:0008837; GO:0009089 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P33013 DACD_ECOLI D-alanyl-D-alanine carboxypeptidase DacD (DD-carboxypeptidase) (DD-peptidase) (EC 3.4.16.4) (Penicillin-binding protein 6b) (PBP-6b) dacD phsE yeeC b2010 JW5329 phsE yeeC dacD 43,346 cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan metabolic process [GO:0000270]; regulation of cell shape [GO:0008360] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; beta-lactamase activity [GO:0008800]; carboxypeptidase activity [GO:0004180]; penicillin binding [GO:0008658]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan metabolic process [GO:0000270]; regulation of cell shape [GO:0008360] beta-lactamase activity [GO:0008800]; carboxypeptidase activity [GO:0004180]; penicillin binding [GO:0008658]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002] GO:0000270; GO:0004180; GO:0005886; GO:0008360; GO:0008658; GO:0008800; GO:0009002; GO:0009252; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=N-terminal lies in the periplasmic space. {ECO:0000305}. +P0ABR1 DINI_ECOLI DNA damage-inducible protein I dinI b1061 JW1048 dinI 8,949 DNA repair [GO:0006281]; SOS response [GO:0009432] enzyme binding [GO:0019899]; DNA repair [GO:0006281]; SOS response [GO:0009432] enzyme binding [GO:0019899] GO:0006281; GO:0009432; GO:0019899 +P0AEF4 DPIA_ECOLI Transcriptional regulatory protein DpiA (Destabilizer of plasmid inheritance) dpiA citB criR mpdA b0620 JW0612 citB criR mpdA dpiA 25,453 phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; phosphorelay response regulator activity [GO:0000156]; phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; phosphorelay response regulator activity [GO:0000156] GO:0000156; GO:0000160; GO:0003677; GO:0003700; GO:0005737; GO:0006355 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0CE47 EFTU1_ECOLI Elongation factor Tu 1 (EF-Tu 1) (Bacteriophage Q beta RNA-directed RNA polymerase subunit III) (P-43) tufA b3339 JW3301 tufA 43,284 response to antibiotic [GO:0046677]; translational elongation [GO:0006414] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation elongation factor activity [GO:0003746]; response to antibiotic [GO:0046677]; translational elongation [GO:0006414] GTPase activity [GO:0003924]; GTP binding [GO:0005525]; translation elongation factor activity [GO:0003746] GO:0003746; GO:0003924; GO:0005525; GO:0005737; GO:0005886; GO:0006414; GO:0046677 SUBCELLULAR LOCATION: Cytoplasm. Cell inner membrane; Peripheral membrane protein. Note=Between 50-80% of the protein is associated with the cell inner membrane. Localization to the membrane has been suggested to follow nutrient stress. +P75855 ELFA_ECOLI Fimbrial subunit ElfA elfA ycbQ b0938 JW5122 ycbQ elfA 18,680 cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000269|PubMed:20345943}. +P77357 ABGA_ECOLI p-aminobenzoyl-glutamate hydrolase subunit A (EC 3.5.1.-) (PABA-GLU hydrolase) (PGH) abgA ydaJ b1338 JW5205 ydaJ abgA 46,588 folic acid catabolic process [GO:0046657] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; dipeptidase activity [GO:0016805]; para-aminobenzoyl-glutamate hydrolase activity [GO:0071713]; protein heterodimerization activity [GO:0046982]; folic acid catabolic process [GO:0046657] dipeptidase activity [GO:0016805]; para-aminobenzoyl-glutamate hydrolase activity [GO:0071713]; protein heterodimerization activity [GO:0046982] GO:0005737; GO:0016805; GO:0046657; GO:0046982; GO:0071713 +P37686 ADH2_ECOLI Probable alcohol dehydrogenase (EC 1.1.1.1) yiaY b3589 JW5648 yiaY 40,351 cytosol [GO:0005829] cytosol [GO:0005829]; alcohol dehydrogenase (NAD+) activity [GO:0004022]; L-threonine 3-dehydrogenase activity [GO:0008743]; metal ion binding [GO:0046872] alcohol dehydrogenase (NAD+) activity [GO:0004022]; L-threonine 3-dehydrogenase activity [GO:0008743]; metal ion binding [GO:0046872] GO:0004022; GO:0005829; GO:0008743; GO:0046872 +P77610 ANSP_ECOLI L-asparagine permease (L-asparagine transport protein) ansP yncF b1453 JW5234 yncF ansP 54,233 amino acid transport [GO:0006865]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; amino acid transport [GO:0006865]; transmembrane transport [GO:0055085] GO:0005886; GO:0006865; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0AAF6 ARTP_ECOLI Arginine transport ATP-binding protein ArtP (EC 7.4.2.-) artP b0864 JW0848 artP 27,022 L-arginine import across plasma membrane [GO:0097638] ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled polar amino acid-transporter activity [GO:0015426]; ATPase-coupled transmembrane transporter activity [GO:0042626]; L-arginine import across plasma membrane [GO:0097638] ATPase-coupled polar amino acid-transporter activity [GO:0015426]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0015426; GO:0042626; GO:0055052; GO:0097638 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P41407 AZOR_ECOLI FMN-dependent NADH:quinone oxidoreductase (EC 1.6.5.-) (Azo-dye reductase) (FMN-dependent NADH-azo compound oxidoreductase) (FMN-dependent NADH-azoreductase) (EC 1.7.1.17) azoR acpD b1412 JW1409 acpD azoR 21,658 response to oxidative stress [GO:0006979] cytosol [GO:0005829] cytosol [GO:0005829]; azobenzene reductase activity [GO:0050446]; electron transfer activity [GO:0009055]; FMN binding [GO:0010181]; oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor [GO:0016652]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655]; response to oxidative stress [GO:0006979] azobenzene reductase activity [GO:0050446]; electron transfer activity [GO:0009055]; FMN binding [GO:0010181]; oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor [GO:0016652]; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655] GO:0005829; GO:0006979; GO:0009055; GO:0010181; GO:0016652; GO:0016655; GO:0050446 +P31552 CAIC_ECOLI Crotonobetaine/carnitine--CoA ligase (EC 6.2.1.48) (Betaine:CoA ligase) caiC yaaM b0037 JW0036 yaaM caiC 58,559 carnitine metabolic process [GO:0009437] acid-thiol ligase activity [GO:0016878]; carnitine-CoA ligase activity [GO:0051108]; CoA-ligase activity [GO:0016405]; crotonobetaine-CoA ligase activity [GO:0051109]; carnitine metabolic process [GO:0009437] acid-thiol ligase activity [GO:0016878]; carnitine-CoA ligase activity [GO:0051108]; CoA-ligase activity [GO:0016405]; crotonobetaine-CoA ligase activity [GO:0051109] GO:0009437; GO:0016405; GO:0016878; GO:0051108; GO:0051109 +P69490 CCME_ECOLI Cytochrome c-type biogenesis protein CcmE (Cytochrome c maturation protein E) (Heme chaperone CcmE) ccmE yejS b2197 JW2185 yejS ccmE 17,698 cytochrome c-heme linkage [GO:0018063]; heme transport [GO:0015886] integral component of membrane [GO:0016021]; intrinsic component of periplasmic side of plasma membrane [GO:0031237] integral component of membrane [GO:0016021]; intrinsic component of periplasmic side of plasma membrane [GO:0031237]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; cytochrome c-heme linkage [GO:0018063]; heme transport [GO:0015886] heme binding [GO:0020037]; metal ion binding [GO:0046872] GO:0015886; GO:0016021; GO:0018063; GO:0020037; GO:0031237; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01959}; Single-pass type II membrane protein {ECO:0000255|HAMAP-Rule:MF_01959}; Periplasmic side {ECO:0000255|HAMAP-Rule:MF_01959}. Note=Stabilized by CcmD in the membrane. +P75858 ELFG_ECOLI Uncharacterized fimbrial-like protein ElfG elfG ycbT b0941 JW0924 ycbT elfG 37,851 cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711]; response to radiation [GO:0009314] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711]; response to radiation [GO:0009314] GO:0009289; GO:0009314; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. +P25798 FLIF_ECOLI Flagellar M-ring protein fliF fla AII.1 fla BI b1938 JW1922 fla AII.1 fla BI fliF 60,589 bacterial-type flagellum-dependent cell motility [GO:0071973] bacterial-type flagellum basal body, MS ring [GO:0009431]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] bacterial-type flagellum basal body, MS ring [GO:0009431]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; motor activity [GO:0003774]; bacterial-type flagellum-dependent cell motility [GO:0071973] motor activity [GO:0003774] GO:0003774; GO:0005886; GO:0009431; GO:0016021; GO:0071973 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. Bacterial flagellum basal body {ECO:0000269|PubMed:15919996}. +P07821 FHUC_ECOLI Iron(3+)-hydroxamate import ATP-binding protein FhuC (EC 7.2.2.16) (Ferric hydroxamate uptake protein C) (Ferrichrome transport ATP-binding protein FhuC) (Iron(III)-hydroxamate import ATP-binding protein FhuC) fhuC b0151 JW0147 fhuC 28,886 ATP-binding cassette (ABC) transporter complex [GO:0043190] ATP-binding cassette (ABC) transporter complex [GO:0043190]; ABC-type ferric hydroxamate transporter activity [GO:0015625]; ATP binding [GO:0005524] ABC-type ferric hydroxamate transporter activity [GO:0015625]; ATP binding [GO:0005524] GO:0005524; GO:0015625; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:1551849}; Peripheral membrane protein {ECO:0000269|PubMed:1551849}. Note=FhuB mediates the association of FhuC with the cytoplasmic membrane. {ECO:0000269|PubMed:1551849}. +P52627 FLIZ_ECOLI Regulator of sigma S factor FliZ fliZ yedH b1921 JW1906 yedH fliZ 21,658 DNA integration [GO:0015074]; regulation of bacterial-type flagellum-dependent cell motility [GO:1902021] core promoter sequence-specific DNA binding [GO:0001046]; sigma factor antagonist activity [GO:0016989]; DNA integration [GO:0015074]; regulation of bacterial-type flagellum-dependent cell motility [GO:1902021] core promoter sequence-specific DNA binding [GO:0001046]; sigma factor antagonist activity [GO:0016989] GO:0001046; GO:0015074; GO:0016989; GO:1902021 +P13036 FECA_ECOLI Fe(3+) dicitrate transport protein FecA (Iron(III) dicitrate transport protein FecA) fecA b4291 JW4251 fecA 85,322 iron ion homeostasis [GO:0055072]; iron ion transport [GO:0006826] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; ferric iron transmembrane transporter activity [GO:0015091]; siderophore uptake transmembrane transporter activity [GO:0015344]; signaling receptor activity [GO:0038023]; iron ion homeostasis [GO:0055072]; iron ion transport [GO:0006826] ferric iron transmembrane transporter activity [GO:0015091]; siderophore uptake transmembrane transporter activity [GO:0015344]; signaling receptor activity [GO:0038023] GO:0006826; GO:0009279; GO:0015091; GO:0015344; GO:0016021; GO:0038023; GO:0055072 SUBCELLULAR LOCATION: Cell outer membrane. +P78055 FSAA_ECOLI Fructose-6-phosphate aldolase 1 (EC 4.1.2.-) (Fructose-6-phosphate aldolase A) (FSAA) fsaA fsa mipB ybiZ b0825 JW5109 fsa mipB ybiZ fsaA 22,997 fructose metabolic process [GO:0006000] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; fructose 6-phosphate aldolase activity [GO:0097023]; fructose metabolic process [GO:0006000] fructose 6-phosphate aldolase activity [GO:0097023] GO:0005737; GO:0006000; GO:0097023 SUBCELLULAR LOCATION: Cytoplasm. +P0AEP9 GLCD_ECOLI Glycolate oxidase subunit GlcD (EC 1.1.99.14) (Glycolate dehydrogenase subunit GlcD) glcD gox yghM b2979 JW2946 gox yghM glcD 53,812 cellular response to DNA damage stimulus [GO:0006974]; glycolate catabolic process [GO:0046296] glycolate oxidase complex [GO:0009339]; plasma membrane [GO:0005886] glycolate oxidase complex [GO:0009339]; plasma membrane [GO:0005886]; D-2-hydroxy-acid dehydrogenase activity [GO:0047809]; FAD binding [GO:0071949]; glycolate dehydrogenase activity [GO:0019154]; glycolate oxidase activity [GO:0008891]; cellular response to DNA damage stimulus [GO:0006974]; glycolate catabolic process [GO:0046296] D-2-hydroxy-acid dehydrogenase activity [GO:0047809]; FAD binding [GO:0071949]; glycolate dehydrogenase activity [GO:0019154]; glycolate oxidase activity [GO:0008891] GO:0005886; GO:0006974; GO:0008891; GO:0009339; GO:0019154; GO:0046296; GO:0047809; GO:0071949 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:2689218}. Note=Glycolate oxidoreductase activity was shown to be firmly associated with the cytoplasmic membranes. {ECO:0000269|PubMed:2689218}. +P30128 GREB_ECOLI Transcription elongation factor GreB (Transcript cleavage factor GreB) greB b3406 JW3369 greB 18,527 DNA-templated transcription, elongation [GO:0006354]; DNA-templated transcription, initiation [GO:0006352]; positive regulation of mRNA cleavage [GO:0031439]; regulation of DNA-templated transcription, elongation [GO:0032784] DNA binding [GO:0003677]; RNA polymerase binding [GO:0070063]; DNA-templated transcription, elongation [GO:0006354]; DNA-templated transcription, initiation [GO:0006352]; positive regulation of mRNA cleavage [GO:0031439]; regulation of DNA-templated transcription, elongation [GO:0032784] DNA binding [GO:0003677]; RNA polymerase binding [GO:0070063] GO:0003677; GO:0006352; GO:0006354; GO:0031439; GO:0032784; GO:0070063 +P75713 ALLE_ECOLI (S)-ureidoglycine aminohydrolase (UGHY) (UGlyAH) (EC 3.5.3.26) allE glxB6 ylbA b0515 JW0503 glxB6 ylbA allE 28,730 purine nucleobase metabolic process [GO:0006144] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; manganese ion binding [GO:0030145]; ureidoglycine aminohydrolase activity [GO:0071522]; purine nucleobase metabolic process [GO:0006144] manganese ion binding [GO:0030145]; ureidoglycine aminohydrolase activity [GO:0071522] GO:0005737; GO:0006144; GO:0030145; GO:0071522 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19935661, ECO:0000269|PubMed:20038185}. +P19926 AGP_ECOLI Glucose-1-phosphatase (G1Pase) (EC 3.1.3.10) agp b1002 JW0987 agp 45,683 dephosphorylation [GO:0016311]; glucose catabolic process [GO:0006007] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; 3-phytase activity [GO:0016158]; glucose-1-phosphatase activity [GO:0008877]; phosphatase activity [GO:0016791]; sugar-phosphatase activity [GO:0050308]; dephosphorylation [GO:0016311]; glucose catabolic process [GO:0006007] 3-phytase activity [GO:0016158]; glucose-1-phosphatase activity [GO:0008877]; phosphatase activity [GO:0016791]; sugar-phosphatase activity [GO:0050308] GO:0006007; GO:0008877; GO:0016158; GO:0016311; GO:0016791; GO:0030288; GO:0050308 SUBCELLULAR LOCATION: Periplasm. +P45956 CAS2_ECOLI CRISPR-associated endoribonuclease Cas2 (EC 3.1.-.-) ygbF cas2 b2754 JW5438 cas2 ygbF 10,518 defense response to virus [GO:0051607]; maintenance of CRISPR repeat elements [GO:0043571] DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; defense response to virus [GO:0051607]; maintenance of CRISPR repeat elements [GO:0043571] DNA binding [GO:0003677]; endonuclease activity [GO:0004519] GO:0003677; GO:0004519; GO:0043571; GO:0051607 +P0A9H9 CHEZ_ECOLI Protein phosphatase CheZ (EC 3.1.3.-) (Chemotaxis protein CheZ) cheZ b1881 JW1870 cheZ 23,976 bacterial-type flagellum-dependent swarming motility [GO:0071978]; chemotaxis [GO:0006935]; protein dephosphorylation [GO:0006470]; regulation of chemotaxis [GO:0050920] bacterial-type flagellum [GO:0009288]; cytosol [GO:0005829]; methyl accepting chemotaxis protein complex [GO:0098561]; plasma membrane [GO:0005886] bacterial-type flagellum [GO:0009288]; cytosol [GO:0005829]; methyl accepting chemotaxis protein complex [GO:0098561]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; phosphoprotein phosphatase activity [GO:0004721]; bacterial-type flagellum-dependent swarming motility [GO:0071978]; chemotaxis [GO:0006935]; protein dephosphorylation [GO:0006470]; regulation of chemotaxis [GO:0050920] identical protein binding [GO:0042802]; phosphoprotein phosphatase activity [GO:0004721] GO:0004721; GO:0005829; GO:0005886; GO:0006470; GO:0006935; GO:0009288; GO:0042802; GO:0050920; GO:0071978; GO:0098561 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12644507}. Note=Colocalizes with CheA chemoreceptor patches near the cell poles, which requires CheA(short). +P0ABH9 CLPA_ECOLI ATP-dependent Clp protease ATP-binding subunit ClpA clpA lopD b0882 JW0866 lopD clpA 84,207 cellular response to heat [GO:0034605]; protein unfolding [GO:0043335]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; ATP-dependent peptidase activity [GO:0004176]; ATPase activity [GO:0016887]; cellular response to heat [GO:0034605]; protein unfolding [GO:0043335]; response to oxidative stress [GO:0006979] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; ATP-dependent peptidase activity [GO:0004176] GO:0004176; GO:0005524; GO:0005737; GO:0005829; GO:0006979; GO:0016887; GO:0034605; GO:0043335 +P11557 DAMX_ECOLI Cell division protein DamX damX yhfB b3388 JW3351 yhfB damX 46,162 cytokinetic process [GO:0032506] cell division site [GO:0032153]; cell septum [GO:0030428]; integral component of plasma membrane [GO:0005887] cell division site [GO:0032153]; cell septum [GO:0030428]; integral component of plasma membrane [GO:0005887]; peptidoglycan binding [GO:0042834]; cytokinetic process [GO:0032506] peptidoglycan binding [GO:0042834] GO:0005887; GO:0030428; GO:0032153; GO:0032506; GO:0042834 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02021}. Note=Localizes at the septal ring (PubMed:19684127, PubMed:19880599, PubMed:23290046). Recruitment to the septal ring requires FtsZ (PubMed:19880599). {ECO:0000269|PubMed:19684127, ECO:0000269|PubMed:19880599, ECO:0000269|PubMed:23290046}. +P0ACF0 DBHA_ECOLI DNA-binding protein HU-alpha (HU-2) (NS2) hupA b4000 JW3964 hupA 9,535 cellular response to DNA damage stimulus [GO:0006974]; chromosome condensation [GO:0030261]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829]; HU-DNA complex [GO:1990178]; membrane [GO:0016020] cytosol [GO:0005829]; HU-DNA complex [GO:1990178]; membrane [GO:0016020]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; cellular response to DNA damage stimulus [GO:0006974]; chromosome condensation [GO:0030261]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; identical protein binding [GO:0042802] GO:0003677; GO:0005829; GO:0006351; GO:0006974; GO:0016020; GO:0030261; GO:0042802; GO:1990178 SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000269|PubMed:21903814}. Note=Scattered throughout the nucleoid (PubMed:21903814). {ECO:0000269|PubMed:21903814}. +P0AC13 DHPS_ECOLI Dihydropteroate synthase (DHPS) (EC 2.5.1.15) (Dihydropteroate pyrophosphorylase) folP dhpS b3177 JW3144 dhpS folP 30,615 folic acid biosynthetic process [GO:0046656]; response to drug [GO:0042493]; tetrahydrofolate biosynthetic process [GO:0046654] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dihydropteroate synthase activity [GO:0004156]; metal ion binding [GO:0046872]; folic acid biosynthetic process [GO:0046656]; response to drug [GO:0042493]; tetrahydrofolate biosynthetic process [GO:0046654] dihydropteroate synthase activity [GO:0004156]; metal ion binding [GO:0046872] GO:0004156; GO:0005737; GO:0005829; GO:0042493; GO:0046654; GO:0046656; GO:0046872 +P23840 DIND_ECOLI DNA damage-inducible protein D dinD pcsA yicD b3645 JW3620 pcsA yicD dinD 31,078 cellular response to DNA damage stimulus [GO:0006974]; SOS response [GO:0009432] cellular response to DNA damage stimulus [GO:0006974]; SOS response [GO:0009432] GO:0006974; GO:0009432 +P0AEG4 DSBA_ECOLI Thiol:disulfide interchange protein DsbA dsbA dsf ppfA b3860 JW3832 dsf ppfA dsbA 23,105 cellular response to antibiotic [GO:0071236] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; protein disulfide isomerase activity [GO:0003756]; protein disulfide oxidoreductase activity [GO:0015035]; cellular response to antibiotic [GO:0071236] protein disulfide isomerase activity [GO:0003756]; protein disulfide oxidoreductase activity [GO:0015035] GO:0003756; GO:0015035; GO:0030288; GO:0071236 SUBCELLULAR LOCATION: Periplasm. +P06968 DUT_ECOLI Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) dut dnaS sof b3640 JW3615 dnaS sof dut 16,287 dUMP biosynthetic process [GO:0006226]; dUTP catabolic process [GO:0046081] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; dUTP diphosphatase activity [GO:0004170]; magnesium ion binding [GO:0000287]; dUMP biosynthetic process [GO:0006226]; dUTP catabolic process [GO:0046081] dUTP diphosphatase activity [GO:0004170]; magnesium ion binding [GO:0000287] GO:0000287; GO:0004170; GO:0005829; GO:0006226; GO:0032991; GO:0046081 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:1311056, ECO:0000305|PubMed:9261872}. +P27303 EMRA_ECOLI Multidrug export protein EmrA emrA b2685 JW2660 emrA 42,736 response to antibiotic [GO:0046677]; response to toxic substance [GO:0009636]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of plasma membrane [GO:0005887]; intrinsic component of plasma membrane [GO:0031226]; outer membrane-bounded periplasmic space [GO:0030288] integral component of plasma membrane [GO:0005887]; intrinsic component of plasma membrane [GO:0031226]; outer membrane-bounded periplasmic space [GO:0030288]; identical protein binding [GO:0042802]; xenobiotic transmembrane transporter activity [GO:0042910]; response to antibiotic [GO:0046677]; response to toxic substance [GO:0009636]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] identical protein binding [GO:0042802]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005887; GO:0009636; GO:0030288; GO:0031226; GO:0042802; GO:0042910; GO:0046677; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:12482849, ECO:0000269|PubMed:1409590}; Single-pass membrane protein {ECO:0000269|PubMed:12482849, ECO:0000269|PubMed:1409590}; Periplasmic side {ECO:0000269|PubMed:12482849, ECO:0000269|PubMed:1409590}. +P0AEK4 FABI_ECOLI Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (ENR) (EC 1.3.1.9) (NADH-dependent enoyl-ACP reductase) fabI envM b1288 JW1281 envM fabI 27,864 biotin biosynthetic process [GO:0009102]; fatty acid elongation [GO:0030497]; lipid biosynthetic process [GO:0008610]; response to antibiotic [GO:0046677] catalytic complex [GO:1902494]; cytosol [GO:0005829]; membrane [GO:0016020] catalytic complex [GO:1902494]; cytosol [GO:0005829]; membrane [GO:0016020]; enoyl-[acyl-carrier-protein] reductase (NADH) activity [GO:0004318]; enoyl-[acyl-carrier-protein] reductase activity [GO:0016631]; identical protein binding [GO:0042802]; NADH binding [GO:0070404]; biotin biosynthetic process [GO:0009102]; fatty acid elongation [GO:0030497]; lipid biosynthetic process [GO:0008610]; response to antibiotic [GO:0046677] enoyl-[acyl-carrier-protein] reductase (NADH) activity [GO:0004318]; enoyl-[acyl-carrier-protein] reductase activity [GO:0016631]; identical protein binding [GO:0042802]; NADH binding [GO:0070404] GO:0004318; GO:0005829; GO:0008610; GO:0009102; GO:0016020; GO:0016631; GO:0030497; GO:0042802; GO:0046677; GO:0070404; GO:1902494 +P0A9W3 ETTA_ECOLI Energy-dependent translational throttle protein EttA (EC 3.6.1.-) (Translational regulatory factor EttA) ettA yjjK b4391 JW4354 yjjK ettA 62,443 negative regulation of translational elongation [GO:0045900]; translation [GO:0006412] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843]; tRNA binding [GO:0000049]; negative regulation of translational elongation [GO:0045900]; translation [GO:0006412] ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843]; tRNA binding [GO:0000049] GO:0000049; GO:0005524; GO:0005737; GO:0006412; GO:0016887; GO:0019843; GO:0042626; GO:0043022; GO:0045900 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00847, ECO:0000269|PubMed:24389466}. Note=Associates with ribosomes and polysomes. {ECO:0000255|HAMAP-Rule:MF_00847}. +P0AC16 FOLB_ECOLI Dihydroneopterin aldolase (DHNA) (EC 4.1.2.25) (7,8-dihydroneopterin 2'-epimerase) (7,8-dihydroneopterin aldolase) (7,8-dihydroneopterin epimerase) (EC 5.1.99.8) (Dihydroneopterin epimerase) folB ygiG b3058 JW3030 ygiG folB 13,620 folic acid biosynthetic process [GO:0046656]; folic acid-containing compound metabolic process [GO:0006760]; tetrahydrofolate biosynthetic process [GO:0046654] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; dihydroneopterin aldolase activity [GO:0004150]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]; folic acid biosynthetic process [GO:0046656]; folic acid-containing compound metabolic process [GO:0006760]; tetrahydrofolate biosynthetic process [GO:0046654] dihydroneopterin aldolase activity [GO:0004150]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853] GO:0004150; GO:0005737; GO:0006760; GO:0016853; GO:0042802; GO:0046654; GO:0046656 +P0AC53 G6PD_ECOLI Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) [Cleaved into: Extracellular death factor (EDF)] zwf b1852 JW1841 zwf 55,704 glucose metabolic process [GO:0006006]; pentose-phosphate shunt [GO:0006098]; quorum sensing [GO:0009372] cytosol [GO:0005829] cytosol [GO:0005829]; glucose-6-phosphate dehydrogenase activity [GO:0004345]; identical protein binding [GO:0042802]; NADP binding [GO:0050661]; glucose metabolic process [GO:0006006]; pentose-phosphate shunt [GO:0006098]; quorum sensing [GO:0009372] glucose-6-phosphate dehydrogenase activity [GO:0004345]; identical protein binding [GO:0042802]; NADP binding [GO:0050661] GO:0004345; GO:0005829; GO:0006006; GO:0006098; GO:0009372; GO:0042802; GO:0050661 +P0AEP1 GALP_ECOLI Galactose-proton symporter (Galactose transporter) galP b2943 JW2910 galP 50,983 galactose transmembrane transport [GO:0015757] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; galactose:proton symporter activity [GO:0015517]; galactose transmembrane transport [GO:0015757] galactose:proton symporter activity [GO:0015517] GO:0005886; GO:0015517; GO:0015757; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P25748 GALS_ECOLI HTH-type transcriptional regulator GalS (Mgl repressor and galactose ultrainduction factor) galS b2151 JW2138 galS 37,357 regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003677; GO:0003700; GO:0006355 +Q46817 GHXQ_ECOLI Guanine/hypoxanthine permease GhxQ ghxQ ygfQ ygfR b4464 JW5467 ygfQ ygfR ghxQ 46,758 guanine import across plasma membrane [GO:0098710]; hypoxanthine transport [GO:0035344] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; guanine transmembrane transporter activity [GO:0015208]; purine nucleobase transmembrane transporter activity [GO:0005345]; guanine import across plasma membrane [GO:0098710]; hypoxanthine transport [GO:0035344] guanine transmembrane transporter activity [GO:0015208]; purine nucleobase transmembrane transporter activity [GO:0005345] GO:0005345; GO:0005886; GO:0005887; GO:0015208; GO:0016020; GO:0035344; GO:0098710 SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24214977}; Multi-pass membrane protein {ECO:0000269|PubMed:24214977}. +P77364 GLXK2_ECOLI Glycerate 3-kinase (EC 2.7.1.31) (D-Glycerate-3-kinase) (Glycerate kinase 2) (GK2) glxK glxB5 ybbZ b0514 JW0502 glxB5 ybbZ glxK 38,734 glycolate catabolic process [GO:0046296]; glyoxylate catabolic process [GO:0009436]; organic acid phosphorylation [GO:0031388] ATP binding [GO:0005524]; glycerate 2-kinase activity [GO:0043798]; glycerate kinase activity [GO:0008887]; glycolate catabolic process [GO:0046296]; glyoxylate catabolic process [GO:0009436]; organic acid phosphorylation [GO:0031388] ATP binding [GO:0005524]; glycerate 2-kinase activity [GO:0043798]; glycerate kinase activity [GO:0008887] GO:0005524; GO:0008887; GO:0009436; GO:0031388; GO:0043798; GO:0046296 +P77463 DDPC_ECOLI Probable D,D-dipeptide transport system permease protein DdpC ddpC yddQ b1485 JW1480 yddQ ddpC 31,971 protein transport [GO:0015031] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; dipeptide transmembrane transporter activity [GO:0071916]; protein transport [GO:0015031] dipeptide transmembrane transporter activity [GO:0071916] GO:0005886; GO:0005887; GO:0015031; GO:0071916 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P24169 DCOS_ECOLI Inducible ornithine decarboxylase (EC 4.1.1.17) speF b0693 JW0680 speF 82,416 putrescine biosynthetic process from ornithine [GO:0033387]; spermidine biosynthetic process [GO:0008295] cytosol [GO:0005829] cytosol [GO:0005829]; carboxy-lyase activity [GO:0016831]; ornithine decarboxylase activity [GO:0004586]; pyridoxal phosphate binding [GO:0030170]; putrescine biosynthetic process from ornithine [GO:0033387]; spermidine biosynthetic process [GO:0008295] carboxy-lyase activity [GO:0016831]; ornithine decarboxylase activity [GO:0004586]; pyridoxal phosphate binding [GO:0030170] GO:0004586; GO:0005829; GO:0008295; GO:0016831; GO:0030170; GO:0033387 +P0A830 DCTA_ECOLI Aerobic C4-dicarboxylate transport protein dctA b3528 JW3496 dctA 45,436 cellular response to DNA damage stimulus [GO:0006974]; fumarate transport [GO:0015741]; L-aspartate transmembrane transport [GO:0070778] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; fumarate transmembrane transporter activity [GO:0015138]; L-aspartate transmembrane transporter activity [GO:0015183]; malate:proton symporter activity [GO:0015366]; succinate transmembrane transporter activity [GO:0015141]; transmembrane transporter activity [GO:0022857]; cellular response to DNA damage stimulus [GO:0006974]; fumarate transport [GO:0015741]; L-aspartate transmembrane transport [GO:0070778] fumarate transmembrane transporter activity [GO:0015138]; L-aspartate transmembrane transporter activity [GO:0015183]; malate:proton symporter activity [GO:0015366]; succinate transmembrane transporter activity [GO:0015141]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0006974; GO:0015138; GO:0015141; GO:0015183; GO:0015366; GO:0015741; GO:0016020; GO:0016021; GO:0022857; GO:0070778 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P37672 DLGD_ECOLI 2,3-diketo-L-gulonate reductase (2,3-DKG reductase) (EC 1.1.1.130) (3-dehydro-L-gulonate 2-dehydrogenase) dlgD yiaK b3575 JW3547 yiaK dlgD 36,573 cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 3-dehydro-L-gulonate 2-dehydrogenase activity [GO:0047559]; NAD+ binding [GO:0070403]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] 3-dehydro-L-gulonate 2-dehydrogenase activity [GO:0047559]; NAD+ binding [GO:0070403]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] GO:0005737; GO:0016616; GO:0047559; GO:0070403 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0ABT5 DUSB_ECOLI tRNA-dihydrouridine synthase B (EC 1.3.1.-) dusB yhdG b3260 JW3228 yhdG dusB 35,866 response to radiation [GO:0009314] flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; tRNA binding [GO:0000049]; tRNA dihydrouridine synthase activity [GO:0017150]; response to radiation [GO:0009314] flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; tRNA binding [GO:0000049]; tRNA dihydrouridine synthase activity [GO:0017150] GO:0000049; GO:0009314; GO:0010181; GO:0017150; GO:0050660 +P0AAI5 FABF_ECOLI 3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC 2.3.1.179) (3-oxoacyl-[acyl-carrier-protein] synthase II) (Beta-ketoacyl-ACP synthase II) (KAS II) fabF fabJ b1095 JW1081 fabJ fabF 43,046 fatty acid biosynthetic process [GO:0006633] cytosol [GO:0005829] cytosol [GO:0005829]; 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; beta-ketoacyl-acyl-carrier-protein synthase II activity [GO:0033817]; fatty acid biosynthetic process [GO:0006633] 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; beta-ketoacyl-acyl-carrier-protein synthase II activity [GO:0033817] GO:0004315; GO:0005829; GO:0006633; GO:0033817 +P15029 FECD_ECOLI Fe(3+) dicitrate transport system permease protein FecD (Iron(III) dicitrate transport system permease protein FecD) fecD b4288 JW4248 fecD 34,131 siderophore-dependent iron import into cell [GO:0033214] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; iron chelate transmembrane transporter activity [GO:0015603]; transmembrane transporter activity [GO:0022857]; siderophore-dependent iron import into cell [GO:0033214] iron chelate transmembrane transporter activity [GO:0015603]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0015603; GO:0022857; GO:0033214 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A8P3 FETP_ECOLI Probable Fe(2+)-trafficking protein yggX b2962 JW2929 yggX 10,953 cellular response to oxidative stress [GO:0034599] cytosol [GO:0005829] cytosol [GO:0005829]; iron ion binding [GO:0005506]; cellular response to oxidative stress [GO:0034599] iron ion binding [GO:0005506] GO:0005506; GO:0005829; GO:0034599 +P52067 FSR_ECOLI Fosmidomycin resistance protein fsr b0479 JW0468 fsr 43,306 cellular response to DNA damage stimulus [GO:0006974]; response to antibiotic [GO:0046677] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; cellular response to DNA damage stimulus [GO:0006974]; response to antibiotic [GO:0046677] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0006974; GO:0022857; GO:0046677 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A6T3 GAL1_ECOLI Galactokinase (EC 2.7.1.6) (Galactose kinase) galK galA b0757 JW0740 galA galK 41,442 galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; galactokinase activity [GO:0004335]; magnesium ion binding [GO:0000287]; galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012] ATP binding [GO:0005524]; galactokinase activity [GO:0004335]; magnesium ion binding [GO:0000287] GO:0000287; GO:0004335; GO:0005524; GO:0005737; GO:0005829; GO:0006012; GO:0033499 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00246}. +P0C8J8 GATZ_ECOLI D-tagatose-1,6-bisphosphate aldolase subunit GatZ gatZ b2095 JW2082 gatZ 47,109 D-tagatose 6-phosphate catabolic process [GO:2001059]; galactitol catabolic process [GO:0019404]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; catalytic activity [GO:0003824]; D-tagatose 6-phosphate catabolic process [GO:2001059]; galactitol catabolic process [GO:0019404]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] catalytic activity [GO:0003824] GO:0003824; GO:0005887; GO:0009401; GO:0019404; GO:2001059 +P76445 LPXT_ECOLI Lipid A 1-diphosphate synthase (EC 2.7.4.29) (Kdo(2)-lipid A phosphotransferase) (Undecaprenyl pyrophosphate:lipid A 1-phosphate phosphotransferase) lpxT yeiU b2174 JW2162 yeiU lpxT 26,759 Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; phosphotransferase activity, phosphate group as acceptor [GO:0016776]; undecaprenyl-diphosphatase activity [GO:0050380]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103] phosphotransferase activity, phosphate group as acceptor [GO:0016776]; undecaprenyl-diphosphatase activity [GO:0050380] GO:0005886; GO:0005887; GO:0009103; GO:0009245; GO:0016776; GO:0043165; GO:0050380 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01945, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:17660416}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01945, ECO:0000269|PubMed:17660416}. Note=Transferase activity takes place on the periplamic side of the inner membrane. {ECO:0000255|HAMAP-Rule:MF_01945, ECO:0000269|PubMed:18047581}. +P75747 ABRB_ECOLI Putative regulator AbrB (AidB regulator) abrB ybgN b0715 JW5097 ECK0704 ybgN abrB 36,884 regulation of gene expression [GO:0010468] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; regulation of gene expression [GO:0010468] GO:0005886; GO:0010468; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0A6C5 ARGA_ECOLI Amino-acid acetyltransferase (EC 2.3.1.1) (N-acetylglutamate synthase) (AGS) (NAGS) argA b2818 JW2786 argA 49,195 arginine biosynthetic process [GO:0006526] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; acetyl-CoA:L-glutamate N-acetyltransferase activity [GO:0004042]; glutamate N-acetyltransferase activity [GO:0004358]; methione N-acyltransferase activity [GO:0103045]; arginine biosynthetic process [GO:0006526] acetyl-CoA:L-glutamate N-acetyltransferase activity [GO:0004042]; glutamate N-acetyltransferase activity [GO:0004358]; methione N-acyltransferase activity [GO:0103045] GO:0004042; GO:0004358; GO:0005737; GO:0006526; GO:0103045 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:16890}. +P0AE24 ARAE_ECOLI Arabinose-proton symporter (Arabinose transporter) araE b2841 JW2809 araE 51,684 fucose transmembrane transport [GO:0015756]; L-arabinose transmembrane transport [GO:0042882] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; fucose transmembrane transporter activity [GO:0015150]; L-arabinose transmembrane transporter activity [GO:0015147]; symporter activity [GO:0015293]; fucose transmembrane transport [GO:0015756]; L-arabinose transmembrane transport [GO:0042882] fucose transmembrane transporter activity [GO:0015150]; L-arabinose transmembrane transporter activity [GO:0015147]; symporter activity [GO:0015293] GO:0005886; GO:0005887; GO:0015147; GO:0015150; GO:0015293; GO:0015756; GO:0042882 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0ABF6 CDD_ECOLI Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) (CDA) cdd b2143 JW2131 cdd 31,540 cytidine deamination [GO:0009972]; deoxycytidine catabolic process [GO:0006217]; nucleobase-containing small molecule interconversion [GO:0015949] cytosol [GO:0005829] cytosol [GO:0005829]; cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; identical protein binding [GO:0042802]; pyrimidine nucleoside binding [GO:0001884]; zinc ion binding [GO:0008270]; cytidine deamination [GO:0009972]; deoxycytidine catabolic process [GO:0006217]; nucleobase-containing small molecule interconversion [GO:0015949] cytidine deaminase activity [GO:0004126]; deoxycytidine deaminase activity [GO:0047844]; identical protein binding [GO:0042802]; pyrimidine nucleoside binding [GO:0001884]; zinc ion binding [GO:0008270] GO:0001884; GO:0004126; GO:0005829; GO:0006217; GO:0008270; GO:0009972; GO:0015949; GO:0042802; GO:0047844 +P0A6I9 COAE_ECOLI Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase) coaE yacE b0103 JW0100 yacE coaE 22,622 coenzyme A biosynthetic process [GO:0015937] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; dephospho-CoA kinase activity [GO:0004140]; coenzyme A biosynthetic process [GO:0015937] ATP binding [GO:0005524]; dephospho-CoA kinase activity [GO:0004140] GO:0004140; GO:0005524; GO:0005737; GO:0015937 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00376, ECO:0000305}. +P76175 CLCB_ECOLI Voltage-gated ClC-type chloride channel ClcB clcB mriT ynfJ b1592 JW5263 mriT ynfJ clcB 44,153 chloride transport [GO:0006821]; regulation of ion transmembrane transport [GO:0034765]; response to acidic pH [GO:0010447] chloride channel complex [GO:0034707]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] chloride channel complex [GO:0034707]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; voltage-gated chloride channel activity [GO:0005247]; chloride transport [GO:0006821]; regulation of ion transmembrane transport [GO:0034765]; response to acidic pH [GO:0010447] voltage-gated chloride channel activity [GO:0005247] GO:0005247; GO:0005886; GO:0005887; GO:0006821; GO:0010447; GO:0034707; GO:0034765 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A978 CSPG_ECOLI Cold shock-like protein CspG (CPS-G) cspG cspI b0990 JW0974 cspI cspG 7,781 negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468]; response to cold [GO:0009409] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; transcription antitermination factor activity, RNA binding [GO:0001072]; negative regulation of DNA-templated transcription, termination [GO:0060567]; regulation of gene expression [GO:0010468]; response to cold [GO:0009409] DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; transcription antitermination factor activity, RNA binding [GO:0001072] GO:0001072; GO:0003676; GO:0003677; GO:0003723; GO:0005829; GO:0009409; GO:0010468; GO:0060567 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P0AC84 GLO2_ECOLI Hydroxyacylglutathione hydrolase GloB (EC 3.1.2.6) (Glyoxalase II) (Glx II) gloB yafR b0212 JW0202 yafR gloB 28,434 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]; response to heat [GO:0009408]; response to toxic substance [GO:0009636] hydroxyacylglutathione hydrolase activity [GO:0004416]; zinc ion binding [GO:0008270]; methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]; response to heat [GO:0009408]; response to toxic substance [GO:0009636] hydroxyacylglutathione hydrolase activity [GO:0004416]; zinc ion binding [GO:0008270] GO:0004416; GO:0008270; GO:0009408; GO:0009636; GO:0019243 +P10371 HIS4_ECOLI 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC 5.3.1.16) (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase) hisA b2024 JW2006 hisA 26,033 cellular response to DNA damage stimulus [GO:0006974]; histidine biosynthetic process [GO:0000105]; tryptophan biosynthetic process [GO:0000162] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity [GO:0003949]; cellular response to DNA damage stimulus [GO:0006974]; histidine biosynthetic process [GO:0000105]; tryptophan biosynthetic process [GO:0000162] 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity [GO:0003949] GO:0000105; GO:0000162; GO:0003949; GO:0005737; GO:0005829; GO:0006974 SUBCELLULAR LOCATION: Cytoplasm. +P0AGK8 ISCR_ECOLI HTH-type transcriptional regulator IscR iscR yfhP b2531 JW2515 yfhP iscR 17,337 regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; 2 iron, 2 sulfur cluster binding [GO:0051537]; DNA-binding transcription factor activity [GO:0003700]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; regulation of transcription, DNA-templated [GO:0006355] 2 iron, 2 sulfur cluster binding [GO:0051537]; DNA-binding transcription factor activity [GO:0003700]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506] GO:0003690; GO:0003700; GO:0005506; GO:0005829; GO:0006355; GO:0042802; GO:0051537 +P0CE57 INH10_ECOLI Transposase InsH for insertion sequence element IS5R insH10 b3218 JW3185 insH10 37,851 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0AB74 KBAY_ECOLI D-tagatose-1,6-bisphosphate aldolase subunit KbaY (TBPA) (TagBP aldolase) (EC 4.1.2.40) (D-tagatose-bisphosphate aldolase class II) (Ketose 1,6-bisphosphate aldolase class II) (Tagatose-bisphosphate aldolase) kbaY agaY kba yraC b3137 JW3106 agaY kba yraC kbaY 31,294 carbohydrate metabolic process [GO:0005975]; D-tagatose 6-phosphate catabolic process [GO:2001059] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; tagatose-bisphosphate aldolase activity [GO:0009025]; zinc ion binding [GO:0008270]; carbohydrate metabolic process [GO:0005975]; D-tagatose 6-phosphate catabolic process [GO:2001059] identical protein binding [GO:0042802]; tagatose-bisphosphate aldolase activity [GO:0009025]; zinc ion binding [GO:0008270] GO:0005829; GO:0005975; GO:0008270; GO:0009025; GO:0032991; GO:0042802; GO:2001059 +P0AEX3 KGTP_ECOLI Alpha-ketoglutarate permease kgtP witA b2587 JW2571 witA kgtP 47,052 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; solute:cation symporter activity [GO:0015294] solute:cation symporter activity [GO:0015294] GO:0005886; GO:0015294; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0AEJ4 ENVZ_ECOLI Sensor histidine kinase EnvZ (EC 2.7.13.3) (Osmolarity sensor protein EnvZ) envZ ompB perA tpo b3404 JW3367 ompB perA tpo envZ 50,334 peptidyl-histidine phosphorylation [GO:0018106]; phosphorelay signal transduction system [GO:0000160]; phosphorylation [GO:0016310]; protein autophosphorylation [GO:0046777]; protein dephosphorylation [GO:0006470]; response to osmotic stress [GO:0006970]; signal transduction [GO:0007165] cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288] cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155]; peptidyl-histidine phosphorylation [GO:0018106]; phosphorelay signal transduction system [GO:0000160]; phosphorylation [GO:0016310]; protein autophosphorylation [GO:0046777]; protein dephosphorylation [GO:0006470]; response to osmotic stress [GO:0006970]; signal transduction [GO:0007165] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155] GO:0000155; GO:0000160; GO:0004721; GO:0005524; GO:0005829; GO:0005887; GO:0006470; GO:0006970; GO:0007165; GO:0016310; GO:0018106; GO:0030288; GO:0042802; GO:0046777 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:1323560, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2824492}; Multi-pass membrane protein {ECO:0000305|PubMed:1323560, ECO:0000305|PubMed:15919996, ECO:0000305|PubMed:2824492}. +P0AEH3 ELAA_ECOLI Protein ElaA elaA yfbC b2267 JW2262 yfbC elaA 17,420 N-acetyltransferase activity [GO:0008080]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] N-acetyltransferase activity [GO:0008080]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] GO:0008080; GO:0016747 +P0AB01 ELYC_ECOLI Envelope biogenesis factor ElyC (Elevated frequency of lysis) elyC ycbC b0920 JW0903 ycbC elyC 28,666 cell wall organization [GO:0071555]; Gram-negative-bacterium-type cell wall biogenesis [GO:0043164]; peptidoglycan metabolic process [GO:0000270]; protein folding [GO:0006457] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cell wall organization [GO:0071555]; Gram-negative-bacterium-type cell wall biogenesis [GO:0043164]; peptidoglycan metabolic process [GO:0000270]; protein folding [GO:0006457] GO:0000270; GO:0005886; GO:0006457; GO:0016021; GO:0043164; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0A9S3 GATD_ECOLI Galactitol 1-phosphate 5-dehydrogenase (EC 1.1.1.251) gatD b2091 JW2075 gatD 37,390 galactitol catabolic process [GO:0019404] cytosol [GO:0005829] cytosol [GO:0005829]; galactitol-1-phosphate 5-dehydrogenase activity [GO:0008868]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; galactitol catabolic process [GO:0019404] galactitol-1-phosphate 5-dehydrogenase activity [GO:0008868]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] GO:0005829; GO:0008270; GO:0008868; GO:0019404; GO:0042802 +P37666 GHRB_ECOLI Glyoxylate/hydroxypyruvate reductase B (EC 1.1.1.79) (EC 1.1.1.81) (2-ketoaldonate reductase) (2-ketogluconate reductase) (2KR) (EC 1.1.1.215) ghrB tkrA yiaE b3553 JW5656 tkrA yiaE ghrB 35,396 D-gluconate metabolic process [GO:0019521]; ketogluconate catabolic process [GO:0046181] cytosol [GO:0005829]; plasma membrane [GO:0005886] cytosol [GO:0005829]; plasma membrane [GO:0005886]; gluconate 2-dehydrogenase activity [GO:0008873]; glycerate dehydrogenase activity [GO:0008465]; glyoxylate reductase (NADP+) activity [GO:0030267]; hydroxypyruvate reductase activity [GO:0016618]; NAD binding [GO:0051287]; D-gluconate metabolic process [GO:0019521]; ketogluconate catabolic process [GO:0046181] gluconate 2-dehydrogenase activity [GO:0008873]; glycerate dehydrogenase activity [GO:0008465]; glyoxylate reductase (NADP+) activity [GO:0030267]; hydroxypyruvate reductase activity [GO:0016618]; NAD binding [GO:0051287] GO:0005829; GO:0005886; GO:0008465; GO:0008873; GO:0016618; GO:0019521; GO:0030267; GO:0046181; GO:0051287 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P07762 GLGB_ECOLI 1,4-alpha-glucan branching enzyme GlgB (EC 2.4.1.18) (1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase) (Alpha-(1->4)-glucan branching enzyme) (Glycogen branching enzyme) (BE) glgB b3432 JW3395 glgB 84,337 carbohydrate metabolic process [GO:0005975]; cellular response to DNA damage stimulus [GO:0006974]; glycogen biosynthetic process [GO:0005978] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; 1,4-alpha-glucan branching enzyme activity [GO:0003844]; 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) [GO:0102752]; cation binding [GO:0043169]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; carbohydrate metabolic process [GO:0005975]; cellular response to DNA damage stimulus [GO:0006974]; glycogen biosynthetic process [GO:0005978] 1,4-alpha-glucan branching enzyme activity [GO:0003844]; 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) [GO:0102752]; cation binding [GO:0043169]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553] GO:0003844; GO:0004553; GO:0005737; GO:0005829; GO:0005975; GO:0005978; GO:0006974; GO:0043169; GO:0102752 +P0AER5 GLTK_ECOLI Glutamate/aspartate import permease protein GltK gltK b0653 JW0648 gltK 24,915 amino acid transport [GO:0006865]; toxin transport [GO:1901998] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; amino acid transport [GO:0006865]; toxin transport [GO:1901998] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0006865; GO:0022857; GO:0043190; GO:1901998 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P0AAG3 GLTL_ECOLI Glutamate/aspartate import ATP-binding protein GltL (EC 7.4.2.1) gltL b0652 JW0647 gltL 26,661 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled L-glutamine transmembrane transporter activity [GO:0015599]; ATPase-coupled transmembrane transporter activity [GO:0042626] ATPase-coupled L-glutamine transmembrane transporter activity [GO:0015599]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0015599; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:9593292}; Peripheral membrane protein {ECO:0000305|PubMed:9593292}. +P13033 GLPB_ECOLI Anaerobic glycerol-3-phosphate dehydrogenase subunit B (Anaerobic G-3-P dehydrogenase subunit B) (Anaerobic G3Pdhase B) (EC 1.1.5.3) glpB b2242 JW2236 glpB 45,357 anaerobic respiration [GO:0009061]; glycerol-3-phosphate catabolic process [GO:0046168]; glycerol catabolic process [GO:0019563] cytosol [GO:0005829]; glycerol-3-phosphate dehydrogenase complex [GO:0009331]; plasma membrane [GO:0005886] cytosol [GO:0005829]; glycerol-3-phosphate dehydrogenase complex [GO:0009331]; plasma membrane [GO:0005886]; FMN binding [GO:0010181]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368]; sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity [GO:0052591]; anaerobic respiration [GO:0009061]; glycerol catabolic process [GO:0019563]; glycerol-3-phosphate catabolic process [GO:0046168] FMN binding [GO:0010181]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368]; sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity [GO:0052591] GO:0004368; GO:0005829; GO:0005886; GO:0009061; GO:0009331; GO:0010181; GO:0019563; GO:0046168; GO:0052591 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase. +P27305 GLUQ_ECOLI Glutamyl-Q tRNA(Asp) synthetase (Glu-Q-RSs) (EC 6.1.1.-) gluQ yadB b0144 JW5892 yadB gluQ 34,868 glutamyl-tRNA aminoacylation [GO:0006424]; tRNA wobble base modification [GO:0002097] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; zinc ion binding [GO:0008270]; glutamyl-tRNA aminoacylation [GO:0006424]; tRNA wobble base modification [GO:0002097] ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; zinc ion binding [GO:0008270] GO:0002097; GO:0004818; GO:0005524; GO:0005829; GO:0006424; GO:0008270 +P0A6H5 HSLU_ECOLI ATP-dependent protease ATPase subunit HslU (Heat shock protein HslU) (Unfoldase HslU) hslU htpI b3931 JW3902 htpI hslU 49,594 protein unfolding [GO:0043335]; proteolysis [GO:0006508]; response to heat [GO:0009408] cytosol [GO:0005829]; HslUV protease complex [GO:0009376]; membrane [GO:0016020] cytosol [GO:0005829]; HslUV protease complex [GO:0009376]; membrane [GO:0016020]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; peptidase activity [GO:0008233]; protein domain specific binding [GO:0019904]; protein unfolding [GO:0043335]; proteolysis [GO:0006508]; response to heat [GO:0009408] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; peptidase activity [GO:0008233]; protein domain specific binding [GO:0019904] GO:0000287; GO:0005524; GO:0005829; GO:0006508; GO:0008233; GO:0009376; GO:0009408; GO:0016020; GO:0016887; GO:0019904; GO:0042802; GO:0043335 SUBCELLULAR LOCATION: Cytoplasm. +P45750 HOFP_ECOLI DNA utilization protein HofP hofP yrfA b3392 JW5694 yrfA hofP 15,098 carbon utilization [GO:0015976]; DNA catabolic process [GO:0006308] carbon utilization [GO:0015976]; DNA catabolic process [GO:0006308] GO:0006308; GO:0015976 +P0C054 IBPA_ECOLI Small heat shock protein IbpA (16 kDa heat shock protein A) ibpA hslT htpN b3687 JW3664 hslT htpN ibpA 15,774 protein stabilization [GO:0050821]; response to heat [GO:0009408] cytosol [GO:0005829] cytosol [GO:0005829]; identical protein binding [GO:0042802]; protein stabilization [GO:0050821]; response to heat [GO:0009408] identical protein binding [GO:0042802] GO:0005829; GO:0009408; GO:0042802; GO:0050821 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14702418}. +P77625 HXPA_ECOLI Hexitol phosphatase A (Mannitol-1-phosphatase) (EC 3.1.3.22) (Sorbitol-6-phosphatase) (EC 3.1.3.50) (Sugar-phosphatase) (EC 3.1.3.23) hxpA yfbT b2293 JW5376 yfbT hxpA 23,008 carbohydrate metabolic process [GO:0005975] beta-phosphoglucomutase activity [GO:0008801]; cobalt ion binding [GO:0050897]; glycerol-3-phosphatase activity [GO:0043136]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; mannitol-1-phosphatase activity [GO:0050084]; sorbitol-6-phosphatase activity [GO:0050286]; sugar-phosphatase activity [GO:0050308]; carbohydrate metabolic process [GO:0005975] beta-phosphoglucomutase activity [GO:0008801]; cobalt ion binding [GO:0050897]; glycerol-3-phosphatase activity [GO:0043136]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; mannitol-1-phosphatase activity [GO:0050084]; sorbitol-6-phosphatase activity [GO:0050286]; sugar-phosphatase activity [GO:0050308] GO:0000287; GO:0005975; GO:0008801; GO:0030145; GO:0043136; GO:0050084; GO:0050286; GO:0050308; GO:0050897 +P0AAN9 IRAP_ECOLI Anti-adapter protein IraP iraP yaiB b0382 JW0373 yaiB iraP 9,937 cellular response to phosphate starvation [GO:0016036]; negative regulation of protein catabolic process [GO:0042177] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; anti-sigma factor antagonist activity [GO:0043856]; cellular response to phosphate starvation [GO:0016036]; negative regulation of protein catabolic process [GO:0042177] anti-sigma factor antagonist activity [GO:0043856] GO:0005737; GO:0016036; GO:0042177; GO:0043856 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0C0L9 ISCX_ECOLI Protein IscX iscX yfhJ b2524 JW2508 yfhJ iscX 7,732 iron-sulfur cluster assembly [GO:0016226] cytosol [GO:0005829] cytosol [GO:0005829]; enzyme inhibitor activity [GO:0004857]; ferrous iron binding [GO:0008198]; iron ion binding [GO:0005506]; iron-sulfur cluster assembly [GO:0016226] enzyme inhibitor activity [GO:0004857]; ferrous iron binding [GO:0008198]; iron ion binding [GO:0005506] GO:0004857; GO:0005506; GO:0005829; GO:0008198; GO:0016226 +P57998 INSB4_ECOLI Insertion element IS1 4 protein InsB (IS1d) insB4 b0988 JW0972 insB4 19,700 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P19767 INSA7_ECOLI Insertion element IS1 7 protein InsA (IS1f) insA7 b4294 JW4254 insA7 9,925 transposition, DNA-mediated [GO:0006313] transposition, DNA-mediated [GO:0006313] GO:0006313 +P0CF60 INSD8_ECOLI Putative transposase InsD for insertion element IS2E insD8 b1578 JW1570 insD8 24,724 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0032196 +P0CF68 INSE3_ECOLI Transposase InsE for insertion sequence IS3C insE3 b0540 JW5074 insE3 11,543 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CF55 INSD3_ECOLI Transposase InsD for insertion element IS2F insD3 b1996 JW1975 insD3 34,398 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0032196 +P0CF89 INSI3_ECOLI Transposase InsI for insertion sequence element IS30C insI3 b1404 JW1401 insI3 44,281 DNA integration [GO:0015074]; transposition [GO:0032196]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; DNA integration [GO:0015074]; transposition [GO:0032196]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313; GO:0015074; GO:0032196 +P04951 KDSB_ECOLI 3-deoxy-manno-octulosonate cytidylyltransferase (EC 2.7.7.38) (CMP-2-keto-3-deoxyoctulosonic acid synthase) (CKS) (CMP-KDO synthase) kdsB b0918 JW0901 kdsB 27,614 CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process [GO:0033468]; keto-3-deoxy-D-manno-octulosonic acid biosynthetic process [GO:0019294] cytosol [GO:0005829] cytosol [GO:0005829]; 3-deoxy-manno-octulosonate cytidylyltransferase activity [GO:0008690]; magnesium ion binding [GO:0000287]; CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process [GO:0033468]; keto-3-deoxy-D-manno-octulosonic acid biosynthetic process [GO:0019294] 3-deoxy-manno-octulosonate cytidylyltransferase activity [GO:0008690]; magnesium ion binding [GO:0000287] GO:0000287; GO:0005829; GO:0008690; GO:0019294; GO:0033468 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00057}. +P0A6A6 LEUC_ECOLI 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase) leuC b0072 JW0071 leuC 49,882 branched-chain amino acid biosynthetic process [GO:0009082]; leucine biosynthetic process [GO:0009098] cytosol [GO:0005829] cytosol [GO:0005829]; 3-isopropylmalate dehydratase activity [GO:0003861]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; branched-chain amino acid biosynthetic process [GO:0009082]; leucine biosynthetic process [GO:0009098] 3-isopropylmalate dehydratase activity [GO:0003861]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0003861; GO:0005829; GO:0009082; GO:0009098; GO:0046872; GO:0051539 +P33232 LLDD_ECOLI L-lactate dehydrogenase (EC 1.1.-.-) lldD lctD b3605 JW3580 lctD lldD 42,728 aerobic respiration [GO:0009060]; lactate oxidation [GO:0019516]; L-fucose catabolic process [GO:0042355] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; FMN binding [GO:0010181]; L-lactate dehydrogenase activity [GO:0004459]; aerobic respiration [GO:0009060]; L-fucose catabolic process [GO:0042355]; lactate oxidation [GO:0019516] FMN binding [GO:0010181]; L-lactate dehydrogenase activity [GO:0004459] GO:0004459; GO:0005886; GO:0009060; GO:0010181; GO:0019516; GO:0042355 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01559, ECO:0000269|PubMed:18473}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01559, ECO:0000269|PubMed:18473}. +P77184 LOMR_ECOLI Putative protein LomR lomR b4570 JW5884/JW5904 b1369/b1371 lomR 5,888 host outer membrane [GO:0044384] host outer membrane [GO:0044384] GO:0044384 +P75958 LOLE_ECOLI Lipoprotein-releasing system transmembrane protein LolE lolE ycfW b1118 JW1104 ycfW lolE 45,344 lipoprotein localization to outer membrane [GO:0044874]; lipoprotein transport [GO:0042953] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; lipoprotein releasing activity [GO:0140306]; lipoprotein localization to outer membrane [GO:0044874]; lipoprotein transport [GO:0042953] lipoprotein releasing activity [GO:0140306] GO:0005886; GO:0005887; GO:0042953; GO:0044874; GO:0098797; GO:0140306 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AD74 LPF2_ECOLI Phenylalanine--tRNA ligase operon leader peptide (pheST attenuator peptide) pheM phtL b1715 JW1705 phtL pheM 1,762 regulation of transcription, DNA-templated [GO:0006355] regulation of transcription, DNA-templated [GO:0006355] GO:0006355 +P68187 MALK_ECOLI Maltose/maltodextrin import ATP-binding protein MalK (EC 7.5.2.1) malK b4035 JW3995 malK 40,990 maltodextrin transport [GO:0042956]; maltose transport [GO:0015768] ATP-binding cassette (ABC) transporter complex [GO:0043190]; ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; maltose transport complex [GO:1990060]; membrane [GO:0016020] ATP-binding cassette (ABC) transporter complex [GO:0043190]; ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; maltose transport complex [GO:1990060]; membrane [GO:0016020]; ABC-type maltose transporter activity [GO:0015423]; activating transcription factor binding [GO:0033613]; ATP binding [GO:0005524]; maltodextrin transport [GO:0042956]; maltose transport [GO:0015768] ABC-type maltose transporter activity [GO:0015423]; activating transcription factor binding [GO:0033613]; ATP binding [GO:0005524] GO:0005524; GO:0015423; GO:0015768; GO:0016020; GO:0031234; GO:0033613; GO:0042956; GO:0043190; GO:0055052; GO:1990060 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01709, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:18456666}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01709, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:18456666}. +P24186 FOLD_ECOLI Bifunctional protein FolD [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] folD ads b0529 JW0518 ads folD 31,044 histidine biosynthetic process [GO:0000105]; methionine biosynthetic process [GO:0009086]; purine nucleotide biosynthetic process [GO:0006164]; tetrahydrofolate interconversion [GO:0035999] cytosol [GO:0005829] cytosol [GO:0005829]; methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488]; histidine biosynthetic process [GO:0000105]; methionine biosynthetic process [GO:0009086]; purine nucleotide biosynthetic process [GO:0006164]; tetrahydrofolate interconversion [GO:0035999] methenyltetrahydrofolate cyclohydrolase activity [GO:0004477]; methylenetetrahydrofolate dehydrogenase (NADP+) activity [GO:0004488] GO:0000105; GO:0004477; GO:0004488; GO:0005829; GO:0006164; GO:0009086; GO:0035999 +P0A6S0 FLGH_ECOLI Flagellar L-ring protein (Basal body L-ring protein) flgH fla FVIII flaY b1079 JW5153 fla FVIII flaY flgH 24,615 bacterial-type flagellum-dependent cell motility [GO:0071973]; response to osmotic stress [GO:0006970] bacterial-type flagellum basal body, distal rod, L ring [GO:0009427]; cell outer membrane [GO:0009279] bacterial-type flagellum basal body, distal rod, L ring [GO:0009427]; cell outer membrane [GO:0009279]; motor activity [GO:0003774]; bacterial-type flagellum-dependent cell motility [GO:0071973]; response to osmotic stress [GO:0006970] motor activity [GO:0003774] GO:0003774; GO:0006970; GO:0009279; GO:0009427; GO:0071973 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Bacterial flagellum basal body {ECO:0000250}. +P29744 FLGL_ECOLI Flagellar hook-associated protein 3 (HAP3) (Hook-filament junction protein) flgL flaT flaU b1083 JW1070 flaT flaU flgL 34,281 bacterial-type flagellum-dependent cell motility [GO:0071973] bacterial-type flagellum hook [GO:0009424]; extracellular region [GO:0005576] bacterial-type flagellum hook [GO:0009424]; extracellular region [GO:0005576]; structural molecule activity [GO:0005198]; bacterial-type flagellum-dependent cell motility [GO:0071973] structural molecule activity [GO:0005198] GO:0005198; GO:0005576; GO:0009424; GO:0071973 SUBCELLULAR LOCATION: Secreted. Bacterial flagellum. +P26608 FLIS_ECOLI Flagellar secretion chaperone FliS fliS b1925 JW1910 fliS 14,950 bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973] cytosol [GO:0005829] cytosol [GO:0005829]; bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973] GO:0005829; GO:0044780; GO:0071973 SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305}. +P0A6S5 FTSB_ECOLI Cell division protein FtsB ftsB ygbQ b2748 JW2718 ygbQ ftsB 11,622 cell division [GO:0051301]; FtsZ-dependent cytokinesis [GO:0043093] cell division site [GO:0032153]; cell septum [GO:0030428]; integral component of plasma membrane [GO:0005887] cell division site [GO:0032153]; cell septum [GO:0030428]; integral component of plasma membrane [GO:0005887]; identical protein binding [GO:0042802]; cell division [GO:0051301]; FtsZ-dependent cytokinesis [GO:0043093] identical protein binding [GO:0042802] GO:0005887; GO:0030428; GO:0032153; GO:0042802; GO:0043093; GO:0051301 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00599, ECO:0000269|PubMed:11972052, ECO:0000269|PubMed:15165235}; Single-pass type II membrane protein {ECO:0000255|HAMAP-Rule:MF_00599, ECO:0000269|PubMed:11972052, ECO:0000269|PubMed:15165235}. Note=Localizes to the division septum. Localization requires FtsQ and FtsL, but not FtsW and FtsI. Localization of FtsB and FtsL is codependent. +P0AC47 FRDB_ECOLI Fumarate reductase iron-sulfur subunit (EC 1.3.5.4) (Quinol-fumarate reductase iron-sulfur subunit) (QFR iron-sulfur subunit) frdB b4153 JW4114 frdB 27,123 anaerobic respiration [GO:0009061]; bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973]; fermentation [GO:0006113]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane fumarate reductase complex [GO:0045284] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane fumarate reductase complex [GO:0045284]; 2 iron, 2 sulfur cluster binding [GO:0051537]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; fumarate reductase (menaquinone) [GO:0102040]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; anaerobic respiration [GO:0009061]; bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973]; fermentation [GO:0006113]; tricarboxylic acid cycle [GO:0006099] 2 iron, 2 sulfur cluster binding [GO:0051537]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; fumarate reductase (menaquinone) [GO:0102040]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872] GO:0005829; GO:0006099; GO:0006113; GO:0009055; GO:0009061; GO:0016020; GO:0044780; GO:0045284; GO:0046872; GO:0051536; GO:0051537; GO:0051538; GO:0051539; GO:0071973; GO:0102040 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:10373108}; Peripheral membrane protein {ECO:0000305|PubMed:10373108}; Cytoplasmic side {ECO:0000305|PubMed:10373108}. +P0AAP3 FRMR_ECOLI Transcriptional repressor FrmR frmR yaiN b0357 JW0348 yaiN frmR 10,318 negative regulation of transcription, DNA-templated [GO:0045892] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GO:0003677; GO:0005737; GO:0045892; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P64646 GHOT_ECOLI Toxin GhoT ghoT yjdO b4559 JW5732 yjdO ghoT 6,555 cell death [GO:0008219] cell pole [GO:0060187]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] cell pole [GO:0060187]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cell death [GO:0008219] GO:0005886; GO:0008219; GO:0016020; GO:0016021; GO:0060187 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:24373067}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes to the cell pole. {ECO:0000269|PubMed:24373067}. +P0DQD7 GNDA_ECOLI Protein GndA gndA gndA 5,956 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:29039649}; Single-pass membrane protein {ECO:0000255}. +P0AER8 GLTS_ECOLI Sodium/glutamate symporter (Glutamate permease) gltS gltC b3653 JW3628 gltC gltS 42,425 L-glutamate transmembrane transport [GO:0015813] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; glutamate:sodium symporter activity [GO:0015501]; symporter activity [GO:0015293]; L-glutamate transmembrane transport [GO:0015813] glutamate:sodium symporter activity [GO:0015501]; symporter activity [GO:0015293] GO:0005886; GO:0015293; GO:0015501; GO:0015813; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02062, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:17269795, ECO:0000269|PubMed:17662058, ECO:0000269|PubMed:2537813}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02062, ECO:0000269|PubMed:17269795, ECO:0000269|PubMed:17662058}. +P0ACG4 HOKC_ECOLI Toxic protein HokC (Protein Gef) hokC gef b4412 JW5002 b0018.1 gef hokC 5,502 integral component of membrane [GO:0016021]; periplasmic space [GO:0042597]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; periplasmic space [GO:0042597]; plasma membrane [GO:0005886] GO:0005886; GO:0016021; GO:0042597 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:1943700}; Single-pass type II membrane protein. +P00547 KHSE_ECOLI Homoserine kinase (HK) (HSK) (EC 2.7.1.39) thrB b0003 JW0002 thrB 33,624 threonine biosynthetic process [GO:0009088] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; homoserine kinase activity [GO:0004413]; threonine biosynthetic process [GO:0009088] ATP binding [GO:0005524]; homoserine kinase activity [GO:0004413] GO:0004413; GO:0005524; GO:0005829; GO:0009088 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A9H3 LDCI_ECOLI Inducible lysine decarboxylase (LDCI) (EC 4.1.1.18) cadA ldcI b4131 JW4092 ldcI cadA 81,260 lysine catabolic process [GO:0006554] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; guanosine tetraphosphate binding [GO:0097216]; identical protein binding [GO:0042802]; lysine decarboxylase activity [GO:0008923]; lysine catabolic process [GO:0006554] guanosine tetraphosphate binding [GO:0097216]; identical protein binding [GO:0042802]; lysine decarboxylase activity [GO:0008923] GO:0005737; GO:0006554; GO:0008923; GO:0042802; GO:0097216 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AEK2 FABG_ECOLI 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Beta-Ketoacyl-acyl carrier protein reductase) (Beta-ketoacyl-ACP reductase) fabG b1093 JW1079 fabG 25,560 biotin biosynthetic process [GO:0009102]; fatty acid biosynthetic process [GO:0006633]; fatty acid elongation [GO:0030497]; lipid biosynthetic process [GO:0008610] cytosol [GO:0005829] cytosol [GO:0005829]; 3-oxo-glutaryl-[acp] methyl ester reductase activity [GO:0102131]; 3-oxo-pimeloyl-[acp] methyl ester reductase activity [GO:0102132]; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; biotin biosynthetic process [GO:0009102]; fatty acid biosynthetic process [GO:0006633]; fatty acid elongation [GO:0030497]; lipid biosynthetic process [GO:0008610] 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; 3-oxo-glutaryl-[acp] methyl ester reductase activity [GO:0102131]; 3-oxo-pimeloyl-[acp] methyl ester reductase activity [GO:0102132]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] GO:0004316; GO:0005829; GO:0006633; GO:0008610; GO:0009102; GO:0016616; GO:0030497; GO:0042802; GO:0046872; GO:0050661; GO:0051287; GO:0102131; GO:0102132 +P38134 ETK_ECOLI Tyrosine-protein kinase etk (EC 2.7.10.-) etk yccC b0981 JW0964 yccC etk 81,242 extracellular polysaccharide biosynthetic process [GO:0045226]; lipopolysaccharide biosynthetic process [GO:0009103]; peptidyl-tyrosine autophosphorylation [GO:0038083] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; extracellular polysaccharide biosynthetic process [GO:0045226]; lipopolysaccharide biosynthetic process [GO:0009103]; peptidyl-tyrosine autophosphorylation [GO:0038083] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714] GO:0004713; GO:0004714; GO:0005524; GO:0005886; GO:0009103; GO:0016021; GO:0038083; GO:0042802; GO:0045226 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. Note=When the protein is overexpressed. +P61949 FLAV_ECOLI Flavodoxin 1 (Flavodoxin A) fldA b0684 JW0671 fldA 19,737 cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; electron transfer activity [GO:0009055]; FMN binding [GO:0010181] electron transfer activity [GO:0009055]; FMN binding [GO:0010181] GO:0005737; GO:0005829; GO:0009055; GO:0010181 +P07822 FHUD_ECOLI Iron(3+)-hydroxamate-binding protein FhuD (Ferric hydroxamate uptake protein D) (Ferrichrome-binding periplasmic protein) (Iron(III)-hydroxamate-binding protein FhuD) fhuD b0152 JW0148 fhuD 32,998 ion transport [GO:0006811]; iron ion homeostasis [GO:0055072] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; ion transport [GO:0006811]; iron ion homeostasis [GO:0055072] GO:0006811; GO:0030288; GO:0055072 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:17218314}. +P45543 FRLD_ECOLI Fructoselysine 6-kinase (EC 2.7.1.218) frlD yhfQ b3374 JW3337 yhfQ frlD 28,332 ATP binding [GO:0005524]; carbohydrate kinase activity [GO:0019200]; phosphotransferase activity, alcohol group as acceptor [GO:0016773] ATP binding [GO:0005524]; carbohydrate kinase activity [GO:0019200]; phosphotransferase activity, alcohol group as acceptor [GO:0016773] GO:0005524; GO:0016773; GO:0019200 +P0AC19 FOLX_ECOLI Dihydroneopterin triphosphate 2'-epimerase (EC 5.1.99.7) (D-erythro-7,8-dihydroneopterin triphosphate epimerase) folX b2303 JW2300 folX 14,082 folic acid-containing compound metabolic process [GO:0006760] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dihydroneopterin aldolase activity [GO:0004150]; dihydroneopterin triphosphate 2'-epimerase activity [GO:0008719]; folic acid-containing compound metabolic process [GO:0006760] dihydroneopterin aldolase activity [GO:0004150]; dihydroneopterin triphosphate 2'-epimerase activity [GO:0008719] GO:0004150; GO:0005737; GO:0005829; GO:0006760; GO:0008719 +P17169 GLMS_ECOLI Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase) (GFAT) (Glucosamine-6-phosphate synthase) (Hexosephosphate aminotransferase) (L-glutamine--D-fructose-6-phosphate amidotransferase) glmS b3729 JW3707 glmS 66,894 carbohydrate metabolic process [GO:0005975]; fructose 6-phosphate metabolic process [GO:0006002]; glutamine metabolic process [GO:0006541]; protein N-linked glycosylation [GO:0006487]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]; UDP-N-acetylglucosamine metabolic process [GO:0006047] cytosol [GO:0005829] cytosol [GO:0005829]; carbohydrate derivative binding [GO:0097367]; glutamine-fructose-6-phosphate transaminase (isomerizing) activity [GO:0004360]; carbohydrate metabolic process [GO:0005975]; fructose 6-phosphate metabolic process [GO:0006002]; glutamine metabolic process [GO:0006541]; protein N-linked glycosylation [GO:0006487]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]; UDP-N-acetylglucosamine metabolic process [GO:0006047] carbohydrate derivative binding [GO:0097367]; glutamine-fructose-6-phosphate transaminase (isomerizing) activity [GO:0004360] GO:0004360; GO:0005829; GO:0005975; GO:0006002; GO:0006047; GO:0006048; GO:0006487; GO:0006541; GO:0097367 SUBCELLULAR LOCATION: Cytoplasm. +P0A9F6 GCVA_ECOLI Glycine cleavage system transcriptional activator (Gcv operon activator) gcvA b2808 JW2779 gcvA 34,402 regulation of transcription, DNA-templated [GO:0006355]; response to UV [GO:0009411]; transcription, DNA-templated [GO:0006351] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; regulation of transcription, DNA-templated [GO:0006355]; response to UV [GO:0009411]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0005737; GO:0006351; GO:0006355; GO:0009411; GO:0043565 SUBCELLULAR LOCATION: Cytoplasm. +P77182 MNMC_ECOLI tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC (tRNA mnm(5)s(2)U biosynthesis bifunctional protein) [Includes: tRNA (mnm(5)s(2)U34)-methyltransferase (EC 2.1.1.61); FAD-dependent cmnm(5)s(2)U34 oxidoreductase (EC 1.5.-.-)] mnmC yfcK b2324 JW5380 yfcK mnmC 74,434 tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on the CH-NH group of donors [GO:0016645]; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity [GO:0004808]; tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on the CH-NH group of donors [GO:0016645]; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity [GO:0004808] GO:0002098; GO:0004808; GO:0005737; GO:0016491; GO:0016645; GO:0030488; GO:0071949 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P32125 MOBB_ECOLI Molybdopterin-guanine dinucleotide biosynthesis adapter protein (MGD biosynthesis adapter protein) (Molybdenum cofactor biosynthesis adapter protein) (Moco biosynthesis adapter protein) (Molybdopterin-guanine dinucleotide biosynthesis protein B) mobB yihC b3856 JW5575 yihC mobB 19,363 Mo-molybdopterin cofactor biosynthetic process [GO:0006777] GTP binding [GO:0005525]; nucleotidyltransferase activity [GO:0016779]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777] GTP binding [GO:0005525]; nucleotidyltransferase activity [GO:0016779] GO:0005525; GO:0006777; GO:0016779 +P45756 GSPA_ECOLI Putative general secretion pathway protein A gspA yheD b3323 JW3285 yheD gspA 55,298 cytosol [GO:0005829]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524] ATP binding [GO:0005524] GO:0005524; GO:0005829; GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P69931 HDA_ECOLI DnaA regulatory inactivator Hda (DnaA paralog) (Dp) hda idaB yfgE b2496 JW5397 f248c idaB yfgE hda 26,633 DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; negative regulation of DNA-dependent DNA replication initiation [GO:0032297] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886] cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ADP binding [GO:0043531]; identical protein binding [GO:0042802]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; negative regulation of DNA-dependent DNA replication initiation [GO:0032297] ADP binding [GO:0043531]; identical protein binding [GO:0042802] GO:0005829; GO:0005886; GO:0006260; GO:0006270; GO:0016020; GO:0032297; GO:0042802; GO:0043531 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:12618445}. Note=More protein is found in the inner than outer membrane fractions. +P51020 HOA_ECOLI 4-hydroxy-2-oxovalerate aldolase (HOA) (EC 4.1.3.39) (4-hydroxy-2-keto-pentanoic acid aldolase) (4-hydroxy-2-oxopentanoate aldolase) mhpE b0352 JW0343 mhpE 36,470 3-phenylpropionate catabolic process [GO:0019380]; leucine biosynthetic process [GO:0009098] cytosol [GO:0005829] cytosol [GO:0005829]; 2-isopropylmalate synthase activity [GO:0003852]; 4-hydroxy-2-oxovalerate aldolase activity [GO:0008701]; manganese ion binding [GO:0030145]; 3-phenylpropionate catabolic process [GO:0019380]; leucine biosynthetic process [GO:0009098] 2-isopropylmalate synthase activity [GO:0003852]; 4-hydroxy-2-oxovalerate aldolase activity [GO:0008701]; manganese ion binding [GO:0030145] GO:0003852; GO:0005829; GO:0008701; GO:0009098; GO:0019380; GO:0030145 +P28905 HOLC_ECOLI DNA polymerase III subunit chi (EC 2.7.7.7) holC b4259 JW4216 holC 16,633 DNA replication [GO:0006260]; positive regulation of DNA-dependent DNA replication initiation [GO:0032298]; response to radiation [GO:0009314] DNA polymerase III, clamp loader chi/psi subcomplex [GO:0043847] DNA polymerase III, clamp loader chi/psi subcomplex [GO:0043847]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; DNA replication [GO:0006260]; positive regulation of DNA-dependent DNA replication initiation [GO:0032298]; response to radiation [GO:0009314] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887] GO:0003677; GO:0003887; GO:0006260; GO:0009314; GO:0032298; GO:0043847 +P0ACF8 HNS_ECOLI DNA-binding protein H-NS (Heat-stable nucleoid-structuring protein) (Histone-like protein HLP-II) (Protein B1) (Protein H1) hns bglY cur drdX hnsA msyA osmZ pilG topS b1237 JW1225 bglY cur drdX hnsA msyA osmZ pilG topS hns 15,540 gene silencing [GO:0016458]; negative regulation of single-species biofilm formation on inanimate substrate [GO:1900232]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of translation [GO:0006417] cytosol [GO:0005829]; membrane [GO:0016020]; nucleoid [GO:0009295]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; membrane [GO:0016020]; nucleoid [GO:0009295]; protein-DNA complex [GO:0032993]; bent DNA binding [GO:0003681]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein dimerization activity [GO:0046983]; RNA binding [GO:0003723]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; gene silencing [GO:0016458]; negative regulation of single-species biofilm formation on inanimate substrate [GO:1900232]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of translation [GO:0006417] bent DNA binding [GO:0003681]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein dimerization activity [GO:0046983]; RNA binding [GO:0003723]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0001217; GO:0003680; GO:0003681; GO:0003723; GO:0005829; GO:0006417; GO:0009295; GO:0016020; GO:0016458; GO:0032993; GO:0042802; GO:0045892; GO:0046983; GO:1900232 SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000269|PubMed:21903814, ECO:0000269|PubMed:333393}. Note=Forms 2 compact clusters per chromosome, located at one-quarter and three-quarter positions on the cell's long axis: 2 H-NS-repressed genes were closely associated with H-NS clusters while a non-H-NS-repressed gene was not substantially associated with the H-NS cluster (PubMed:21903814). {ECO:0000269|PubMed:21903814}. +P05791 ILVD_ECOLI Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) ilvD b3771 JW5605 ilvD 65,532 isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; dihydroxy-acid dehydratase activity [GO:0004160]; hydro-lyase activity [GO:0016836]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] 4 iron, 4 sulfur cluster binding [GO:0051539]; dihydroxy-acid dehydratase activity [GO:0004160]; hydro-lyase activity [GO:0016836]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872] GO:0004160; GO:0005829; GO:0009097; GO:0009099; GO:0016836; GO:0046872; GO:0051536; GO:0051539 +P0C058 IBPB_ECOLI Small heat shock protein IbpB (16 kDa heat shock protein B) ibpB hslS htpE b3686 JW3663 hslS htpE ibpB 16,093 protein stabilization [GO:0050821]; response to heat [GO:0009408]; stress response to copper ion [GO:1990169] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; protein stabilization [GO:0050821]; response to heat [GO:0009408]; stress response to copper ion [GO:1990169] identical protein binding [GO:0042802] GO:0005737; GO:0009408; GO:0042802; GO:0050821; GO:1990169 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14702418}. +P0A7A9 IPYR_ECOLI Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) ppa b4226 JW4185 ppa 19,704 phosphate-containing compound metabolic process [GO:0006796] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; inorganic diphosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287]; triphosphatase activity [GO:0050355]; zinc ion binding [GO:0008270]; phosphate-containing compound metabolic process [GO:0006796] inorganic diphosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287]; triphosphatase activity [GO:0050355]; zinc ion binding [GO:0008270] GO:0000287; GO:0004427; GO:0005829; GO:0006796; GO:0008270; GO:0016020; GO:0050355 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00209}. +P69451 LCFA_ECOLI Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) (Long-chain acyl-CoA synthetase) (Acyl-CoA synthetase) fadD oldD b1805 JW1794 oldD fadD 62,332 acyl-CoA metabolic process [GO:0006637]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; lipid metabolic process [GO:0006629]; phospholipid biosynthetic process [GO:0008654]; response to UV [GO:0009411] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; ATP binding [GO:0005524]; decanoate-CoA ligase activity [GO:0102391]; fatty acid binding [GO:0005504]; long-chain fatty acid-CoA ligase activity [GO:0004467]; oleic acid binding [GO:0070538]; acyl-CoA metabolic process [GO:0006637]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; lipid metabolic process [GO:0006629]; phospholipid biosynthetic process [GO:0008654]; response to UV [GO:0009411] ATP binding [GO:0005524]; decanoate-CoA ligase activity [GO:0102391]; fatty acid binding [GO:0005504]; long-chain fatty acid-CoA ligase activity [GO:0004467]; oleic acid binding [GO:0070538] GO:0004467; GO:0005504; GO:0005524; GO:0005737; GO:0005829; GO:0006629; GO:0006631; GO:0006635; GO:0006637; GO:0008654; GO:0009411; GO:0009898; GO:0015908; GO:0070538; GO:0102391 SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Partially membrane-associated. {ECO:0000250}. +P15977 MALQ_ECOLI 4-alpha-glucanotransferase (EC 2.4.1.25) (Amylomaltase) (Disproportionating enzyme) (D-enzyme) malQ malA b3416 JW3379 malA malQ 78,503 glycogen catabolic process [GO:0005980]; maltose catabolic process [GO:0000025] cytosol [GO:0005829] cytosol [GO:0005829]; 4-alpha-glucanotransferase activity [GO:0004134]; beta-maltose 4-alpha-glucanotransferase activity [GO:0102500]; glycogen catabolic process [GO:0005980]; maltose catabolic process [GO:0000025] 4-alpha-glucanotransferase activity [GO:0004134]; beta-maltose 4-alpha-glucanotransferase activity [GO:0102500] GO:0000025; GO:0004134; GO:0005829; GO:0005980; GO:0102500 SUBCELLULAR LOCATION: Cytoplasm. +P77781 MENI_ECOLI 1,4-dihydroxy-2-naphthoyl-CoA hydrolase (DHNA-CoA hydrolase) (EC 3.1.2.28) (DHNA-CoA thioesterase) menI ydiI b1686 JW1676 ydiI menI 14,945 menaquinone biosynthetic process [GO:0009234] cytosol [GO:0005829] cytosol [GO:0005829]; 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity [GO:0061522]; CoA hydrolase activity [GO:0016289]; hydrolase activity [GO:0016787]; menaquinone biosynthetic process [GO:0009234] 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity [GO:0061522]; CoA hydrolase activity [GO:0016289]; hydrolase activity [GO:0016787] GO:0005829; GO:0009234; GO:0016289; GO:0016787; GO:0061522 +P0AEB0 CYSW_ECOLI Sulfate transport system permease protein CysW cysW b2423 JW2416 cysW 32,538 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ABC-type sulfate transporter activity [GO:0015419] ABC-type sulfate transporter activity [GO:0015419] GO:0005886; GO:0015419; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P13518 CSRD_ECOLI RNase E specificity factor CsrD (Regulator of CsrB and CsrC decay CsrD) csrD yhdA b3252 JW3221 yhdA csrD 73,339 ncRNA catabolic process [GO:0034661]; regulation of RNA metabolic process [GO:0051252] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; ncRNA catabolic process [GO:0034661]; regulation of RNA metabolic process [GO:0051252] identical protein binding [GO:0042802] GO:0005886; GO:0016021; GO:0032991; GO:0034661; GO:0042802; GO:0051252 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P21156 CYSD_ECOLI Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) (ATP-sulfurylase small subunit) (Sulfate adenylate transferase) (SAT) cysD b2752 JW2722 cysD 35,188 hydrogen sulfide biosynthetic process [GO:0070814]; response to oxidative stress [GO:0006979]; sulfate assimilation [GO:0000103]; sulfate reduction [GO:0019419]; sulfur compound metabolic process [GO:0006790] ATP binding [GO:0005524]; sulfate adenylyltransferase (ATP) activity [GO:0004781]; hydrogen sulfide biosynthetic process [GO:0070814]; response to oxidative stress [GO:0006979]; sulfate assimilation [GO:0000103]; sulfate reduction [GO:0019419]; sulfur compound metabolic process [GO:0006790] ATP binding [GO:0005524]; sulfate adenylyltransferase (ATP) activity [GO:0004781] GO:0000103; GO:0004781; GO:0005524; GO:0006790; GO:0006979; GO:0019419; GO:0070814 +P0ABS5 DNAG_ECOLI DNA primase (EC 2.7.7.101) dnaG dnaP parB b3066 JW3038 dnaP parB dnaG 65,565 DNA replication, synthesis of RNA primer [GO:0006269] cytoplasm [GO:0005737]; primosome complex [GO:1990077] cytoplasm [GO:0005737]; primosome complex [GO:1990077]; DNA binding [GO:0003677]; DNA primase activity [GO:0003896]; zinc ion binding [GO:0008270]; DNA replication, synthesis of RNA primer [GO:0006269] DNA binding [GO:0003677]; DNA primase activity [GO:0003896]; zinc ion binding [GO:0008270] GO:0003677; GO:0003896; GO:0005737; GO:0006269; GO:0008270; GO:1990077 +P45522 KEFB_ECOLI Glutathione-regulated potassium-efflux system protein KefB (K(+)/H(+) antiporter) (NEM-activable K(+)/H(+) antiporter) kefB trkB b3350 JW3313 trkB kefB 66,411 potassium ion transport [GO:0006813] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; glutathione-regulated potassium exporter activity [GO:0015503]; solute:proton antiporter activity [GO:0015299]; potassium ion transport [GO:0006813] glutathione-regulated potassium exporter activity [GO:0015503]; solute:proton antiporter activity [GO:0015299] GO:0005886; GO:0005887; GO:0006813; GO:0015299; GO:0015503; GO:0016020 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01412, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01412, ECO:0000269|PubMed:15919996}. +P60785 LEPA_ECOLI Elongation factor 4 (EF-4) (EC 3.6.5.n1) (Ribosomal back-translocase LepA) lepA b2569 JW2553 lepA 66,570 positive regulation of translation [GO:0045727]; response to cold [GO:0009409]; response to pH [GO:0009268]; response to salt stress [GO:0009651]; ribosomal small subunit biogenesis [GO:0042274] cytosol [GO:0005829]; plasma membrane [GO:0005886] cytosol [GO:0005829]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanosine tetraphosphate binding [GO:0097216]; identical protein binding [GO:0042802]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; translation elongation factor activity [GO:0003746]; positive regulation of translation [GO:0045727]; response to cold [GO:0009409]; response to pH [GO:0009268]; response to salt stress [GO:0009651]; ribosomal small subunit biogenesis [GO:0042274] GTPase activity [GO:0003924]; GTP binding [GO:0005525]; guanosine tetraphosphate binding [GO:0097216]; identical protein binding [GO:0042802]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; translation elongation factor activity [GO:0003746] GO:0003746; GO:0003924; GO:0005525; GO:0005829; GO:0005886; GO:0009268; GO:0009409; GO:0009651; GO:0042274; GO:0042802; GO:0043022; GO:0043023; GO:0043024; GO:0045727; GO:0097216 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:2999765}; Peripheral membrane protein {ECO:0000305|PubMed:2999765}; Cytoplasmic side {ECO:0000305|PubMed:2999765}. +P0AD79 LPL_ECOLI leu operon leader peptide (leu operon attenuator peptide) leuL leuLP b0075 JW0074 leuLP leuL 3,146 branched-chain amino acid biosynthetic process [GO:0009082]; leucine biosynthetic process [GO:0009098] branched-chain amino acid biosynthetic process [GO:0009082]; leucine biosynthetic process [GO:0009098] GO:0009082; GO:0009098 +P0AD89 LPTN_ECOLI Tryptophanase operon leader peptide tnaC tnaL b3707 JW3685 tnaL tnaC 2,894 positive regulation of tryptophan metabolic process [GO:0090358]; transcriptional attenuation by ribosome [GO:0031556] positive regulation of tryptophan metabolic process [GO:0090358]; transcriptional attenuation by ribosome [GO:0031556] GO:0031556; GO:0090358 +P77265 MDLA_ECOLI Multidrug resistance-like ATP-binding protein MdlA (EC 7.6.2.2) mdlA mdl b0448 JW0438 mdl mdlA 66,017 transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; transmembrane transport [GO:0055085] ABC-type xenobiotic transporter activity [GO:0008559]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0008559; GO:0016021; GO:0042626; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:15919996}. +P00946 MANA_ECOLI Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphohexomutase) (Phosphomannose isomerase) (PMI) manA pmi b1613 JW1605 pmi manA 42,850 cell wall mannoprotein biosynthetic process [GO:0000032]; colanic acid biosynthetic process [GO:0009242]; GDP-mannose biosynthetic process [GO:0009298]; mannose catabolic process [GO:0019309]; protein glycosylation [GO:0006486] cytosol [GO:0005829] cytosol [GO:0005829]; mannose-6-phosphate isomerase activity [GO:0004476]; zinc ion binding [GO:0008270]; cell wall mannoprotein biosynthetic process [GO:0000032]; colanic acid biosynthetic process [GO:0009242]; GDP-mannose biosynthetic process [GO:0009298]; mannose catabolic process [GO:0019309]; protein glycosylation [GO:0006486] mannose-6-phosphate isomerase activity [GO:0004476]; zinc ion binding [GO:0008270] GO:0000032; GO:0004476; GO:0005829; GO:0006486; GO:0008270; GO:0009242; GO:0009298; GO:0019309 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P36554 MDTD_ECOLI Putative multidrug resistance protein MdtD mdtD yegB b2077 JW2062 yegB mdtD 50,901 transmembrane transport [GO:0055085] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; transmembrane transport [GO:0055085] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0022857; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P32166 MENA_ECOLI 1,4-dihydroxy-2-naphthoate octaprenyltransferase (DHNA-octaprenyltransferase) (EC 2.5.1.74) menA yiiW b3930 JW3901 yiiW menA 33,594 menaquinone biosynthetic process [GO:0009234]; ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate [GO:0032194]; vitamin K biosynthetic process [GO:0042371] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity [GO:0046428]; magnesium ion binding [GO:0000287]; prenyltransferase activity [GO:0004659]; menaquinone biosynthetic process [GO:0009234]; ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate [GO:0032194]; vitamin K biosynthetic process [GO:0042371] 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity [GO:0046428]; magnesium ion binding [GO:0000287]; prenyltransferase activity [GO:0004659] GO:0000287; GO:0004659; GO:0005886; GO:0005887; GO:0009234; GO:0016020; GO:0032194; GO:0042371; GO:0046428 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01937, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01937, ECO:0000269|PubMed:15919996}. +P0A9F1 MNTR_ECOLI Transcriptional regulator MntR (Manganese transport regulator) mntR ybiQ b0817 JW0801 ybiQ mntR 17,640 negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of DNA-templated transcription, initiation [GO:2000144] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983]; transition metal ion binding [GO:0046914]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of DNA-templated transcription, initiation [GO:2000144] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; protein dimerization activity [GO:0046983]; transition metal ion binding [GO:0046914] GO:0003677; GO:0003700; GO:0005737; GO:0045892; GO:0046914; GO:0046983; GO:2000144 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P33236 MOKC_ECOLI Regulatory protein MokC mokC gefL b0018 JW5879 gefL mokC 7,742 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:P0ACG4}; Single-pass membrane protein {ECO:0000305}. +P0AD65 MRDA_ECOLI Peptidoglycan D,D-transpeptidase MrdA (EC 3.4.16.4) (Penicillin-binding protein 2) (PBP-2) mrdA pbpA b0635 JW0630 pbpA mrdA 70,857 cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; penicillin binding [GO:0008658]; peptidoglycan L,D-transpeptidase activity [GO:0071972]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] penicillin binding [GO:0008658]; peptidoglycan L,D-transpeptidase activity [GO:0071972]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002] GO:0005886; GO:0005887; GO:0008360; GO:0008658; GO:0009002; GO:0009252; GO:0030288; GO:0046677; GO:0071555; GO:0071972 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02081, ECO:0000269|PubMed:1103132, ECO:0000269|PubMed:3009484}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02081}. Note=Localizes preferentially in the lateral wall and at mid-cell in comparison with the old cell pole. Localization at mid-cell is dependent on active FtsI. {ECO:0000269|PubMed:12519203}. +P08331 CPDB_ECOLI 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase (EC 3.1.3.6) (EC 3.1.4.16) cpdB b4213 JW4171 cpdB 70,832 cellular response to DNA damage stimulus [GO:0006974]; nucleotide catabolic process [GO:0009166] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity [GO:0008663]; 3'-nucleotidase activity [GO:0008254]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; cellular response to DNA damage stimulus [GO:0006974]; nucleotide catabolic process [GO:0009166] 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity [GO:0008663]; 3'-nucleotidase activity [GO:0008254]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166] GO:0000166; GO:0006974; GO:0008254; GO:0008663; GO:0009166; GO:0030288; GO:0042597; GO:0046872 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:3005231}. +P0ABE9 CYNT_ECOLI Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase 1) cynT b0339 JW0330 cynT 23,764 carbon utilization [GO:0015976]; cyanate catabolic process [GO:0009440] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; carbonate dehydratase activity [GO:0004089]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; carbon utilization [GO:0015976]; cyanate catabolic process [GO:0009440] carbonate dehydratase activity [GO:0004089]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] GO:0004089; GO:0005737; GO:0008270; GO:0009440; GO:0015976; GO:0042802 +P69488 CUTA_ECOLI Divalent-cation tolerance protein CutA (C-type cytochrome biogenesis protein CycY) cutA cutA1 cycY b4137 JW4097 cutA1 cycY cutA 12,331 response to copper ion [GO:0046688] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; copper ion binding [GO:0005507]; metal ion binding [GO:0046872]; response to copper ion [GO:0046688] copper ion binding [GO:0005507]; metal ion binding [GO:0046872] GO:0005507; GO:0005737; GO:0046688; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:7623666}. +P0AEE1 DCRB_ECOLI Protein DcrB dcrB yhhR b3472 JW5682 yhhR dcrB 19,787 periplasmic space [GO:0042597] periplasmic space [GO:0042597] GO:0042597 SUBCELLULAR LOCATION: Periplasm. +P0AEE5 DGAL_ECOLI D-galactose-binding periplasmic protein (GBP) (D-galactose/ D-glucose-binding protein) (GGBP) mglB b2150 JW2137 mglB 35,713 chemotaxis [GO:0006935]; galactose transmembrane transport [GO:0015757]; methylgalactoside transport [GO:0015765] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; chemotaxis [GO:0006935]; galactose transmembrane transport [GO:0015757]; methylgalactoside transport [GO:0015765] carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] GO:0006935; GO:0015757; GO:0015765; GO:0030246; GO:0030288; GO:0046872 SUBCELLULAR LOCATION: Periplasm. +P31125 EAMA_ECOLI Probable amino-acid metabolite efflux pump eamA ydeD b1533 JW5250 ydeD eamA 32,324 cellular response to hydrogen peroxide [GO:0070301]; cysteine export across plasma membrane [GO:0033228] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; efflux transmembrane transporter activity [GO:0015562]; cellular response to hydrogen peroxide [GO:0070301]; cysteine export across plasma membrane [GO:0033228] efflux transmembrane transporter activity [GO:0015562] GO:0005886; GO:0005887; GO:0015562; GO:0033228; GO:0070301 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P45762 GSPK_ECOLI Putative type II secretion system protein K (T2SS protein K) (Putative general secretion pathway protein K) gspK yheJ b3332 JW3294 yheJ gspK 37,647 protein secretion [GO:0009306] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein secretion [GO:0009306] GO:0005886; GO:0009306; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:Q00518}. +P13035 GLPD_ECOLI Aerobic glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) glpD glyD b3426 JW3389 glyD glpD 56,751 glycerol-3-phosphate catabolic process [GO:0046168]; glycerol catabolic process [GO:0019563] glycerol-3-phosphate dehydrogenase complex [GO:0009331]; integral component of plasma membrane [GO:0005887] glycerol-3-phosphate dehydrogenase complex [GO:0009331]; integral component of plasma membrane [GO:0005887]; electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368]; sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity [GO:0052590]; sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity [GO:0052591]; glycerol catabolic process [GO:0019563]; glycerol-3-phosphate catabolic process [GO:0046168] electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368]; sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity [GO:0052591]; sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity [GO:0052590] GO:0004368; GO:0005887; GO:0009055; GO:0009331; GO:0019563; GO:0046168; GO:0052590; GO:0052591; GO:0071949 SUBCELLULAR LOCATION: Cytoplasm. +P0ADC6 LPTG_ECOLI Lipopolysaccharide export system permease protein LptG lptG yjgQ b4262 JW5760 yjgQ lptG 39,619 lipopolysaccharide transport [GO:0015920]; transmembrane transport [GO:0055085] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transporter complex [GO:1990351] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transporter complex [GO:1990351]; lipopolysaccharide transport [GO:0015920]; transmembrane transport [GO:0055085] GO:0005886; GO:0015920; GO:0016021; GO:0043190; GO:0055085; GO:1990351 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AEX7 LIVH_ECOLI High-affinity branched-chain amino acid transport system permease protein LivH (LIV-I protein H) livH b3457 JW3422 livH 32,982 branched-chain amino acid transport [GO:0015803]; D-alanine transport [GO:0042941]; isoleucine transmembrane transport [GO:1903714]; L-alanine transport [GO:0015808]; leucine import across plasma membrane [GO:0098713]; L-isoleucine import across plasma membrane [GO:1903806]; L-valine transmembrane transport [GO:1903785]; phenylalanine transport [GO:0015823]; transmembrane transport [GO:0055085] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; branched-chain amino acid transmembrane transporter activity [GO:0015658]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-leucine transmembrane transporter activity [GO:0015190]; L-phenylalanine transmembrane transporter activity [GO:0015192]; L-valine transmembrane transporter activity [GO:0005304]; transmembrane transporter activity [GO:0022857]; branched-chain amino acid transport [GO:0015803]; D-alanine transport [GO:0042941]; isoleucine transmembrane transport [GO:1903714]; L-alanine transport [GO:0015808]; L-isoleucine import across plasma membrane [GO:1903806]; L-valine transmembrane transport [GO:1903785]; leucine import across plasma membrane [GO:0098713]; phenylalanine transport [GO:0015823]; transmembrane transport [GO:0055085] branched-chain amino acid transmembrane transporter activity [GO:0015658]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-leucine transmembrane transporter activity [GO:0015190]; L-phenylalanine transmembrane transporter activity [GO:0015192]; L-valine transmembrane transporter activity [GO:0005304]; transmembrane transporter activity [GO:0022857] GO:0005304; GO:0005886; GO:0005887; GO:0015188; GO:0015190; GO:0015192; GO:0015658; GO:0015803; GO:0015808; GO:0015823; GO:0022857; GO:0042941; GO:0055085; GO:0098713; GO:1903714; GO:1903785; GO:1903806 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +A8DYP9 LPFUR_ECOLI fur leader peptide uof b4637 uof 3,109 regulation of translation [GO:0006417] regulation of translation [GO:0006417] GO:0006417 +P75830 MACA_ECOLI Macrolide export protein MacA macA ybjY b0878 JW0862 ybjY macA 40,624 response to antibiotic [GO:0046677]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] efflux pump complex [GO:1990281]; extrinsic component of membrane [GO:0019898]; MacAB-TolC complex [GO:1990196]; plasma membrane [GO:0005886] efflux pump complex [GO:1990281]; extrinsic component of membrane [GO:0019898]; MacAB-TolC complex [GO:1990196]; plasma membrane [GO:0005886]; efflux transmembrane transporter activity [GO:0015562]; identical protein binding [GO:0042802]; response to antibiotic [GO:0046677]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] efflux transmembrane transporter activity [GO:0015562]; identical protein binding [GO:0042802] GO:0005886; GO:0015562; GO:0019898; GO:0042802; GO:0046677; GO:1990196; GO:1990281; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:11544226, ECO:0000269|PubMed:17214741}; Single-pass membrane protein {ECO:0000269|PubMed:11544226, ECO:0000269|PubMed:17214741}; Periplasmic side {ECO:0000269|PubMed:11544226, ECO:0000269|PubMed:17214741}. +P0A817 METK_ECOLI S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase) metK metX b2942 JW2909 metX metK 41,952 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556]; S-adenosylmethionine cycle [GO:0033353] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; methionine adenosyltransferase activity [GO:0004478]; potassium ion binding [GO:0030955]; one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556]; S-adenosylmethionine cycle [GO:0033353] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; methionine adenosyltransferase activity [GO:0004478]; potassium ion binding [GO:0030955] GO:0000287; GO:0004478; GO:0005524; GO:0005829; GO:0006556; GO:0006730; GO:0030955; GO:0033353; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00086}. +P76250 DMLR_ECOLI HTH-type transcriptional regulator DmlR (D-malate degradation protein R) dmlR yeaT b1799 JW1788 yeaT dmlR 34,631 malate metabolic process [GO:0006108]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; malate metabolic process [GO:0006108]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0006108; GO:0006351; GO:0043565; GO:0045892; GO:0045893 +P46139 DGCN_ECOLI Diguanylate cyclase DgcN (DGC) (EC 2.7.7.65) dgcN yfiN b2604 JW2585 yfiN dgcN 45,989 cell adhesion involved in single-species biofilm formation [GO:0043709]; cellular response to cell envelope stress [GO:0036460]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201]; signal transduction [GO:0007165] cell division site [GO:0032153]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] cell division site [GO:0032153]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; cell adhesion involved in single-species biofilm formation [GO:0043709]; cellular response to cell envelope stress [GO:0036460]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201]; signal transduction [GO:0007165] diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] GO:0005525; GO:0005886; GO:0007165; GO:0016021; GO:0032153; GO:0036460; GO:0042802; GO:0043709; GO:0046872; GO:0052621; GO:1902201 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the midcell in a Z ring-dependent manner in response to cell envelope stress. {ECO:0000269|PubMed:27507823}. +P38101 EAMB_ECOLI Cysteine/O-acetylserine efflux protein eamB yfiK b2578 JW2562 yfiK eamB 21,248 amino acid transport [GO:0006865]; cysteine export across plasma membrane [GO:0033228] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; efflux transmembrane transporter activity [GO:0015562]; amino acid transport [GO:0006865]; cysteine export across plasma membrane [GO:0033228] amino acid transmembrane transporter activity [GO:0015171]; efflux transmembrane transporter activity [GO:0015562] GO:0005886; GO:0005887; GO:0006865; GO:0015171; GO:0015562; GO:0033228 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:12562784}; Multi-pass membrane protein {ECO:0000269|PubMed:12562784}. +P0AA89 DOSC_ECOLI Diguanylate cyclase DosC (DGC) (EC 2.7.7.65) (Direct oxygen-sensing cyclase) dosC dgcO yddV b1490 JW5241 dgcO yddV dosC 53,178 cell adhesion involved in single-species biofilm formation [GO:0043709]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; carbon monoxide binding [GO:0070025]; diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825]; cell adhesion involved in single-species biofilm formation [GO:0043709]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201] carbon monoxide binding [GO:0070025]; diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; oxygen binding [GO:0019825] GO:0005525; GO:0005886; GO:0019825; GO:0020037; GO:0043709; GO:0046872; GO:0052621; GO:0070025; GO:1902201 +P52599 EMRK_ECOLI Probable multidrug resistance protein EmrK emrK b2368 JW2365 emrK 42,585 bile acid and bile salt transport [GO:0015721]; cellular response to DNA damage stimulus [GO:0006974]; response to antibiotic [GO:0046677]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; xenobiotic transmembrane transporter activity [GO:0042910]; bile acid and bile salt transport [GO:0015721]; cellular response to DNA damage stimulus [GO:0006974]; response to antibiotic [GO:0046677]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0006974; GO:0015721; GO:0016021; GO:0042910; GO:0046677; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}; Periplasmic side {ECO:0000305}. +P0ADC3 LOLC_ECOLI Lipoprotein-releasing system transmembrane protein LolC lolC ycfU b1116 JW5161 ycfU lolC 43,264 lipoprotein localization to outer membrane [GO:0044874]; lipoprotein transport [GO:0042953]; protein localization to outer membrane [GO:0089705] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; lipoprotein releasing activity [GO:0140306]; lipoprotein localization to outer membrane [GO:0044874]; lipoprotein transport [GO:0042953]; protein localization to outer membrane [GO:0089705] lipoprotein releasing activity [GO:0140306] GO:0005886; GO:0005887; GO:0030288; GO:0042953; GO:0044874; GO:0089705; GO:0098797; GO:0140306 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P31554 LPTD_ECOLI LPS-assembly protein LptD (Organic solvent tolerance protein) lptD imp ostA yabG b0054 JW0053 imp ostA yabG lptD 89,671 Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; lipopolysaccharide export [GO:0015921]; response to organic substance [GO:0010033] cell outer membrane [GO:0009279]; transporter complex [GO:1990351] cell outer membrane [GO:0009279]; transporter complex [GO:1990351]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; lipopolysaccharide export [GO:0015921]; response to organic substance [GO:0010033] GO:0009279; GO:0010033; GO:0015921; GO:0043165; GO:1990351 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_01411, ECO:0000269|PubMed:12207697, ECO:0000269|PubMed:12724388, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:20446753}. +P26616 MAO1_ECOLI NAD-dependent malic enzyme (NAD-ME) (EC 1.1.1.38) maeA sfcA b1479 JW5238 sfcA maeA 63,197 gluconeogenesis [GO:0006094]; malate metabolic process [GO:0006108]; pyruvate metabolic process [GO:0006090] cytosol [GO:0005829] cytosol [GO:0005829]; malate dehydrogenase (decarboxylating) (NAD+) activity [GO:0004471]; malic enzyme activity [GO:0004470]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; oxaloacetate decarboxylase activity [GO:0008948]; gluconeogenesis [GO:0006094]; malate metabolic process [GO:0006108]; pyruvate metabolic process [GO:0006090] malate dehydrogenase (decarboxylating) (NAD+) activity [GO:0004471]; malic enzyme activity [GO:0004470]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; oxaloacetate decarboxylase activity [GO:0008948] GO:0004470; GO:0004471; GO:0005829; GO:0006090; GO:0006094; GO:0006108; GO:0008948; GO:0046872; GO:0051287 +P69776 LPP_ECOLI Major outer membrane lipoprotein Lpp (Braun lipoprotein) (BLP) (Murein-lipoprotein) lpp mlpA mulI b1677 JW1667 mlpA mulI lpp 8,323 lipid modification [GO:0030258]; periplasmic space organization [GO:0043580] cell outer membrane [GO:0009279]; cell wall [GO:0005618]; extracellular region [GO:0005576]; integral component of cell outer membrane [GO:0045203]; intrinsic component of cell outer membrane [GO:0031230]; membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288] cell outer membrane [GO:0009279]; cell wall [GO:0005618]; extracellular region [GO:0005576]; integral component of cell outer membrane [GO:0045203]; intrinsic component of cell outer membrane [GO:0031230]; membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; peptidoglycan binding [GO:0042834]; lipid modification [GO:0030258]; periplasmic space organization [GO:0043580] identical protein binding [GO:0042802]; lipid binding [GO:0008289]; peptidoglycan binding [GO:0042834] GO:0005576; GO:0005618; GO:0008289; GO:0009279; GO:0016020; GO:0030258; GO:0030288; GO:0031230; GO:0042802; GO:0042834; GO:0043580; GO:0045203 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_00843, ECO:0000269|PubMed:3013869, ECO:0000305|PubMed:4245367}; Lipid-anchor {ECO:0000255|HAMAP-Rule:MF_00843, ECO:0000269|PubMed:3013869, ECO:0000269|PubMed:4245367, ECO:0000269|PubMed:4575979}; Periplasmic side {ECO:0000255|HAMAP-Rule:MF_00843, ECO:0000269|PubMed:4575979}. Secreted, cell wall {ECO:0000255|HAMAP-Rule:MF_00843, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:4245367, ECO:0000269|PubMed:4565677}; Peptidoglycan-anchor {ECO:0000255|HAMAP-Rule:MF_00843, ECO:0000269|PubMed:4245367, ECO:0000269|PubMed:4261992, ECO:0000269|PubMed:4565677, ECO:0000305|PubMed:16079137}. Cell outer membrane {ECO:0000269|PubMed:21219470}; Lipid-anchor {ECO:0000305|PubMed:21219470}; Extracellular side {ECO:0000269|PubMed:21219470}. Note=Attached via its lipidated N-terminus to the inner leaflet of the outer membrane (PubMed:4575979). Attached to the peptidoglycan network (PGN) via its C-terminus (PubMed:4261992, PubMed:4245367) (Probable). About one-third of the protein links the outer membrane and the PGN, the rest is not-linked to PGN. PGN-bound and non-bound forms can interconvert (PubMed:4565677). The C-terminus of the non-PGN-bound form is exposed on the cell surface; its N-terminus is probably anchored in the inner leaflet (PubMed:21219470). Targeted by the SRP/Sec/YidC pathway (PubMed:15140892). {ECO:0000269|PubMed:15140892, ECO:0000269|PubMed:21219470, ECO:0000269|PubMed:4245367, ECO:0000269|PubMed:4261992, ECO:0000269|PubMed:4565677, ECO:0000269|PubMed:4575979, ECO:0000305|PubMed:3013869, ECO:0000305|PubMed:4565677}. +P31547 METI_ECOLI D-methionine transport system permease protein MetI metI yaeE b0198 JW0194 yaeE metI 23,256 amino acid transport [GO:0006865]; D-methionine transport [GO:0048473] ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [GO:0055052]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; L-methionine transmembrane transporter activity [GO:0015191]; amino acid transport [GO:0006865]; D-methionine transport [GO:0048473] L-methionine transmembrane transporter activity [GO:0015191] GO:0005886; GO:0005887; GO:0006865; GO:0015191; GO:0048473; GO:0055052 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P0A744 MSRA_ECOLI Peptide methionine sulfoxide reductase MsrA (Protein-methionine-S-oxide reductase) (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) msrA pms b4219 JW4178 pms msrA 23,315 cellular protein modification process [GO:0006464]; cellular response to oxidative stress [GO:0034599]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; L-methionine-(S)-S-oxide reductase activity [GO:0036456]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; peptide-methionine (S)-S-oxide reductase activity [GO:0008113]; cellular protein modification process [GO:0006464]; cellular response to oxidative stress [GO:0034599]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979] L-methionine-(S)-S-oxide reductase activity [GO:0036456]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; peptide-methionine (S)-S-oxide reductase activity [GO:0008113] GO:0005737; GO:0005829; GO:0006464; GO:0006979; GO:0008113; GO:0016671; GO:0030091; GO:0034599; GO:0036456 +P15047 ENTA_ECOLI 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (DiDHB-DH) (EC 1.3.1.28) (Trans-2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase) entA b0596 JW0588 entA 26,250 enterobactin biosynthetic process [GO:0009239] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity [GO:0008667]; identical protein binding [GO:0042802]; enterobactin biosynthetic process [GO:0009239] 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity [GO:0008667]; identical protein binding [GO:0042802] GO:0005829; GO:0008667; GO:0009239; GO:0032991; GO:0042802 +P77399 FADJ_ECOLI Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase (EC 4.2.1.17) (EC 5.1.2.3); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)] fadJ yfcX b2341 JW2338 yfcX fadJ 77,072 fatty acid beta-oxidation [GO:0006635] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; 3-hydroxybutyryl-CoA epimerase activity [GO:0008692]; enoyl-CoA hydratase activity [GO:0004300]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; NAD+ binding [GO:0070403]; fatty acid beta-oxidation [GO:0006635] 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; 3-hydroxybutyryl-CoA epimerase activity [GO:0008692]; enoyl-CoA hydratase activity [GO:0004300]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; NAD+ binding [GO:0070403] GO:0003857; GO:0004300; GO:0005737; GO:0006635; GO:0008692; GO:0016509; GO:0070403 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P06616 ERA_ECOLI GTPase Era (ERA) (GTP-binding protein Era) era rbaA sdgE b2566 JW2550 rbaA sdgE era 33,810 protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; guanosine tetraphosphate binding [GO:0097216]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; small ribosomal subunit rRNA binding [GO:0070181]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274] GTPase activity [GO:0003924]; GTP binding [GO:0005525]; guanosine tetraphosphate binding [GO:0097216]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; small ribosomal subunit rRNA binding [GO:0070181] GO:0000028; GO:0003723; GO:0003924; GO:0005525; GO:0005737; GO:0005829; GO:0005886; GO:0006468; GO:0019843; GO:0031234; GO:0042274; GO:0043024; GO:0046777; GO:0070181; GO:0097216 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8282709}. Cell inner membrane {ECO:0000269|PubMed:8282709}; Peripheral membrane protein {ECO:0000269|PubMed:8282709}; Cytoplasmic side {ECO:0000269|PubMed:8282709}. Note=Binding is GDP or GTP-dependent, slightly more protein is bound in the presence of GTP than GDP. +P33650 FEOB_ECOLI Fe(2+) transporter FeoB (Ferrous iron transport protein B) feoB b3409 JW3372 feoB 84,474 cellular response to DNA damage stimulus [GO:0006974]; iron ion homeostasis [GO:0055072]; iron ion import across plasma membrane [GO:0098711] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ferrous iron transmembrane transporter activity [GO:0015093]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; cellular response to DNA damage stimulus [GO:0006974]; iron ion homeostasis [GO:0055072]; iron ion import across plasma membrane [GO:0098711] ferrous iron transmembrane transporter activity [GO:0015093]; GTP binding [GO:0005525]; identical protein binding [GO:0042802] GO:0005525; GO:0005886; GO:0005887; GO:0006974; GO:0015093; GO:0042802; GO:0055072; GO:0098711 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein. +P0A9A6 FTSZ_ECOLI Cell division protein FtsZ ftsZ sfiB sulB b0095 JW0093 sfiB sulB ftsZ 40,324 cell division [GO:0051301]; division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093]; protein polymerization [GO:0051258] cell division site [GO:0032153]; cytoplasm [GO:0005737] cell division site [GO:0032153]; cytoplasm [GO:0005737]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; cell division [GO:0051301]; division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093]; protein polymerization [GO:0051258] GTPase activity [GO:0003924]; GTP binding [GO:0005525]; identical protein binding [GO:0042802] GO:0000917; GO:0003924; GO:0005525; GO:0005737; GO:0032153; GO:0042802; GO:0043093; GO:0051258; GO:0051301 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00909, ECO:0000269|PubMed:1944597, ECO:0000269|PubMed:8917533}. Note=Assembles in a ring-like structure at midcell at the inner surface of the cytoplasmic membrane. {ECO:0000269|PubMed:14731269, ECO:0000269|PubMed:1944597, ECO:0000269|PubMed:30343895, ECO:0000269|PubMed:8917533}. +P33195 GCSP_ECOLI Glycine dehydrogenase (decarboxylating) (EC 1.4.4.2) (Glycine cleavage system P-protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring)) gcvP b2903 JW2871 gcvP 104,376 glycine decarboxylation via glycine cleavage system [GO:0019464] cytosol [GO:0005829]; glycine cleavage complex [GO:0005960] cytosol [GO:0005829]; glycine cleavage complex [GO:0005960]; glycine binding [GO:0016594]; glycine dehydrogenase (decarboxylating) activity [GO:0004375]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; glycine decarboxylation via glycine cleavage system [GO:0019464] glycine binding [GO:0016594]; glycine dehydrogenase (decarboxylating) activity [GO:0004375]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170] GO:0004375; GO:0005829; GO:0005960; GO:0016594; GO:0019464; GO:0030170; GO:0042802 +P0A6T5 GCH1_ECOLI GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I) folE b2153 JW2140 folE 24,831 7,8-dihydroneopterin 3'-triphosphate biosynthetic process [GO:0035998]; one-carbon metabolic process [GO:0006730]; queuosine biosynthetic process [GO:0008616]; tetrahydrobiopterin biosynthetic process [GO:0006729]; tetrahydrofolate biosynthetic process [GO:0046654] cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; GTP binding [GO:0005525]; GTP cyclohydrolase I activity [GO:0003934]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; 7,8-dihydroneopterin 3'-triphosphate biosynthetic process [GO:0035998]; one-carbon metabolic process [GO:0006730]; queuosine biosynthetic process [GO:0008616]; tetrahydrobiopterin biosynthetic process [GO:0006729]; tetrahydrofolate biosynthetic process [GO:0046654] GTP binding [GO:0005525]; GTP cyclohydrolase I activity [GO:0003934]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] GO:0003934; GO:0005525; GO:0005737; GO:0005829; GO:0006729; GO:0006730; GO:0008270; GO:0008616; GO:0032991; GO:0035998; GO:0042802; GO:0046654 +P39400 LGOD_ECOLI L-galactonate-5-dehydrogenase (EC 1.1.1.414) lgoD yjjN b4358 JW5793 yjjN lgoD 36,448 L-galactonate catabolic process [GO:0034195] oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; zinc ion binding [GO:0008270]; L-galactonate catabolic process [GO:0034195] oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; zinc ion binding [GO:0008270] GO:0008270; GO:0016616; GO:0034195 +P60716 LIPA_ECOLI Lipoyl synthase (EC 2.8.1.8) (Lip-syn) (LS) (Lipoate synthase) (Lipoic acid synthase) (Sulfur insertion protein LipA) lipA lip b0628 JW0623 lip lipA 36,072 lipoate biosynthetic process [GO:0009107]; protein lipoylation [GO:0009249] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; lipoate synthase activity [GO:0016992]; lipoyl synthase activity (acting on glycine-cleavage complex H protein [GO:0102552]; lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein) [GO:0102553]; metal ion binding [GO:0046872]; lipoate biosynthetic process [GO:0009107]; protein lipoylation [GO:0009249] 4 iron, 4 sulfur cluster binding [GO:0051539]; lipoate synthase activity [GO:0016992]; lipoyl synthase activity (acting on glycine-cleavage complex H protein [GO:0102552]; lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein) [GO:0102553]; metal ion binding [GO:0046872] GO:0005737; GO:0005829; GO:0009107; GO:0009249; GO:0016992; GO:0046872; GO:0051539; GO:0102552; GO:0102553 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00206}. +P77791 MAA_ECOLI Maltose O-acetyltransferase (MAT) (EC 2.3.1.79) (Maltose transacetylase) maa ylaD b0459 JW0448 ylaD maa 20,096 cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; maltose O-acetyltransferase activity [GO:0008925]; O-acyltransferase activity [GO:0008374] identical protein binding [GO:0042802]; maltose O-acetyltransferase activity [GO:0008925]; O-acyltransferase activity [GO:0008374] GO:0005829; GO:0008374; GO:0008925; GO:0032991; GO:0042802 +P0AEZ9 MOAB_ECOLI Molybdenum cofactor biosynthesis protein B moaB chlA2 b0782 JW0765 chlA2 moaB 18,665 Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; protein hexamerization [GO:0034214] cytosol [GO:0005829] cytosol [GO:0005829]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; protein hexamerization [GO:0034214] GTP binding [GO:0005525]; identical protein binding [GO:0042802] GO:0005525; GO:0005829; GO:0006777; GO:0034214; GO:0042802 +P0DKB3 MNTS_ECOLI Small protein MntS mntS rybA b4705 JW0800.1 rybA mntS 5,031 cellular manganese ion homeostasis [GO:0030026]; cellular response to manganese ion [GO:0071287] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; cellular manganese ion homeostasis [GO:0030026]; cellular response to manganese ion [GO:0071287] GO:0005737; GO:0030026; GO:0071287 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21778229}. Note=May be loosely associated with the inner membrane. +Q47141 HCAR_ECOLI Hca operon transcriptional activator HcaR hcaR phdR yfhT b2537 JW2521 phdR yfhT hcaR 32,838 negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] protein-DNA complex [GO:0032993] protein-DNA complex [GO:0032993]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0000986; GO:0003677; GO:0003700; GO:0006355; GO:0032993; GO:0045892; GO:0045893 +P38393 KILR_ECOLI Killing protein KilR (FtsZ inhibitor protein KilR) kilR kil ydaD b1352 JW1347 kil ydaD kilR 8,434 cell cycle [GO:0007049]; cell division [GO:0051301]; negative regulation of cell division [GO:0051782]; response to antibiotic [GO:0046677] cell cycle [GO:0007049]; cell division [GO:0051301]; negative regulation of cell division [GO:0051782]; response to antibiotic [GO:0046677] GO:0007049; GO:0046677; GO:0051301; GO:0051782 +P31474 HSRA_ECOLI Probable transport protein HsrA (High-copy suppressor of rspA) hsrA yieO b3754 JW3733 yieO hsrA 51,462 transmembrane transport [GO:0055085] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; transmembrane transport [GO:0055085] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0022857; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P76341 HIUH_ECOLI 5-hydroxyisourate hydrolase (HIU hydrolase) (HIUHase) (EC 3.5.2.17) (Transthyretin-like protein) (TLP) (Transthyretin-related protein) (TRP) hiuH yedX b1970 JW1953 yedX hiuH 15,460 protein homotetramerization [GO:0051289]; purine nucleobase metabolic process [GO:0006144] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; hydroxyisourate hydrolase activity [GO:0033971]; identical protein binding [GO:0042802]; protein homotetramerization [GO:0051289]; purine nucleobase metabolic process [GO:0006144] hydroxyisourate hydrolase activity [GO:0033971]; identical protein binding [GO:0042802] GO:0006144; GO:0033971; GO:0042597; GO:0042802; GO:0051289 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|Ref.3}. +P37595 IAAA_ECOLI Isoaspartyl peptidase (EC 3.4.19.5) (Beta-aspartyl-peptidase) (EcAIII) (Isoaspartyl dipeptidase) [Cleaved into: Isoaspartyl peptidase subunit alpha; Isoaspartyl peptidase subunit beta] iaaA spt ybiK b0828 JW0812 spt ybiK iaaA 33,394 protein autoprocessing [GO:0016540] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; asparaginase activity [GO:0004067]; beta-aspartyl-peptidase activity [GO:0008798]; hydrolase activity [GO:0016787]; protein autoprocessing [GO:0016540] asparaginase activity [GO:0004067]; beta-aspartyl-peptidase activity [GO:0008798]; hydrolase activity [GO:0016787] GO:0004067; GO:0005737; GO:0008798; GO:0016540; GO:0016787 +P62623 ISPH_ECOLI 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (HMBPP reductase) (EC 1.17.7.4) (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase) ispH lytB yaaE b0029 JW0027 lytB yaaE ispH 34,775 dimethylallyl diphosphate biosynthetic process [GO:0050992]; isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; terpenoid biosynthetic process [GO:0016114] cytosol [GO:0005829] cytosol [GO:0005829]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity [GO:0051745]; hydroxymethylbutenyl pyrophosphate reductase activity [GO:0042380]; metal ion binding [GO:0046872]; dimethylallyl diphosphate biosynthetic process [GO:0050992]; isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; terpenoid biosynthetic process [GO:0016114] 3 iron, 4 sulfur cluster binding [GO:0051538]; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity [GO:0051745]; 4 iron, 4 sulfur cluster binding [GO:0051539]; hydroxymethylbutenyl pyrophosphate reductase activity [GO:0042380]; metal ion binding [GO:0046872] GO:0005829; GO:0016114; GO:0019288; GO:0042380; GO:0046872; GO:0050992; GO:0051538; GO:0051539; GO:0051745 +P71298 INTF_ECOLI Prophage integrase IntF (Putative prophage CP4-6 integrase) intF yagO b0281 JW0275 yagO intF 53,074 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; response to X-ray [GO:0010165]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; response to X-ray [GO:0010165]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0010165; GO:0015074; GO:0044826; GO:0046718; GO:0075713 +P0CF83 INSF5_ECOLI Transposase InsF for insertion sequence IS3E insF5 b2089 JW2073 insF5 33,540 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0032196 +P0CF91 INSL1_ECOLI Putative transposase InsL for insertion sequence element IS186A insL1 b0016 JW0015 insL1 40,909 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P27294 INAA_ECOLI Protein InaA inaA yfaG b2237 JW2231 yfaG inaA 25,296 +P39212 INSN2_ECOLI Putative transposase InsN for insertion sequence element IS911B insN2 b4283 JW5771 insN2 10,344 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P75680 INSO1_ECOLI Putative transposase InsO for insertion sequence element IS911A insO1 b0257 JW0247 insO1 15,850 transposition [GO:0032196] transposition [GO:0032196] GO:0032196 +P0A6I0 KCY_ECOLI Cytidylate kinase (CK) (EC 2.7.4.25) (Cytidine monophosphate kinase) (CMP kinase) (Protein MssA) (p25) cmk mssA ycaF ycaG b0910 JW0893 mssA ycaF ycaG cmk 24,746 nucleobase-containing small molecule interconversion [GO:0015949]; pyrimidine nucleotide metabolic process [GO:0006220]; response to X-ray [GO:0010165] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; CMP kinase activity [GO:0036430]; cytidylate kinase activity [GO:0004127]; dCMP kinase activity [GO:0036431]; nucleobase-containing small molecule interconversion [GO:0015949]; pyrimidine nucleotide metabolic process [GO:0006220]; response to X-ray [GO:0010165] ATP binding [GO:0005524]; CMP kinase activity [GO:0036430]; cytidylate kinase activity [GO:0004127]; dCMP kinase activity [GO:0036431] GO:0004127; GO:0005524; GO:0005829; GO:0006220; GO:0010165; GO:0015949; GO:0036430; GO:0036431 SUBCELLULAR LOCATION: Cytoplasm. +P60720 LIPB_ECOLI Octanoyltransferase (EC 2.3.1.181) (Lipoate-protein ligase B) (Lipoyl/octanoyl transferase) (Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase) lipB b0630 JW5089 lipB 23,883 cellular protein modification process [GO:0006464]; lipoate biosynthetic process [GO:0009107]; lipoate metabolic process [GO:0009106]; negative regulation of gene expression [GO:0010629]; protein lipoylation [GO:0009249] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; catalytic activity [GO:0003824]; lipoyl(octanoyl) transferase activity [GO:0033819]; octanoyl transferase activity (acting on glycine-cleavage complex H protein) [GO:0102555]; octanoyltransferase activity [GO:0016415]; transferase activity [GO:0016740]; cellular protein modification process [GO:0006464]; lipoate biosynthetic process [GO:0009107]; lipoate metabolic process [GO:0009106]; negative regulation of gene expression [GO:0010629]; protein lipoylation [GO:0009249] catalytic activity [GO:0003824]; lipoyl(octanoyl) transferase activity [GO:0033819]; octanoyltransferase activity [GO:0016415]; octanoyl transferase activity (acting on glycine-cleavage complex H protein) [GO:0102555]; transferase activity [GO:0016740] GO:0003824; GO:0005737; GO:0006464; GO:0009106; GO:0009107; GO:0009249; GO:0010629; GO:0016415; GO:0016740; GO:0033819; GO:0102555 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00013}. +P0AD86 LPT_ECOLI thr operon leader peptide (thr operon attenuator) thrL b0001 JW4367 thrL 2,138 threonine biosynthetic process [GO:0009088]; transcriptional attenuation [GO:0031555]; transcriptional attenuation by ribosome [GO:0031556] threonine biosynthetic process [GO:0009088]; transcriptional attenuation [GO:0031555]; transcriptional attenuation by ribosome [GO:0031556] GO:0009088; GO:0031555; GO:0031556 +P75831 MACB_ECOLI Macrolide export ATP-binding/permease protein MacB (EC 7.6.2.-) macB ybjZ b0879 JW0863 ybjZ macB 70,702 response to antibiotic [GO:0046677]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; MacAB-TolC complex [GO:1990196]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; MacAB-TolC complex [GO:1990196]; plasma membrane [GO:0005886]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; efflux transmembrane transporter activity [GO:0015562]; identical protein binding [GO:0042802]; transmembrane transporter activity [GO:0022857]; response to antibiotic [GO:0046677]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; efflux transmembrane transporter activity [GO:0015562]; identical protein binding [GO:0042802]; transmembrane transporter activity [GO:0022857] GO:0005524; GO:0005886; GO:0005887; GO:0008559; GO:0015562; GO:0016021; GO:0022857; GO:0042802; GO:0046677; GO:1990196; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01720, ECO:0000269|PubMed:11544226, ECO:0000269|PubMed:17214741}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01720, ECO:0000269|PubMed:11544226, ECO:0000269|PubMed:17214741}. +P69739 MBHS_ECOLI Hydrogenase-1 small chain (HYD1) (EC 1.12.99.6) (Membrane-bound hydrogenase 1 small subunit) (NiFe hydrogenase) hyaA b0972 JW0954 hyaA 40,681 anaerobic respiration [GO:0009061]; fermentation [GO:0006113] [Ni-Fe] hydrogenase complex [GO:0044569]; ferredoxin hydrogenase complex [GO:0009375]; integral component of membrane [GO:0016021]; intrinsic component of periplasmic side of plasma membrane [GO:0031237]; membrane [GO:0016020] [Ni-Fe] hydrogenase complex [GO:0044569]; ferredoxin hydrogenase complex [GO:0009375]; integral component of membrane [GO:0016021]; intrinsic component of periplasmic side of plasma membrane [GO:0031237]; membrane [GO:0016020]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; ferredoxin hydrogenase activity [GO:0008901]; hydrogenase (acceptor) activity [GO:0033748]; metal ion binding [GO:0046872]; anaerobic respiration [GO:0009061]; fermentation [GO:0006113] 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; ferredoxin hydrogenase activity [GO:0008901]; hydrogenase (acceptor) activity [GO:0033748]; metal ion binding [GO:0046872] GO:0006113; GO:0008901; GO:0009055; GO:0009061; GO:0009375; GO:0016020; GO:0016021; GO:0031237; GO:0033748; GO:0044569; GO:0046872; GO:0051538; GO:0051539 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass type I membrane protein; Periplasmic side. +P64602 MLAB_ECOLI Intermembrane phospholipid transport system binding protein MlaB mlaB yrbB b3191 JW5535 yrbB mlaB 10,680 cellular response to DNA damage stimulus [GO:0006974]; response to antibiotic [GO:0046677] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; ATPase activity [GO:0016887]; cellular response to DNA damage stimulus [GO:0006974]; response to antibiotic [GO:0046677] ATPase activity [GO:0016887] GO:0005829; GO:0006974; GO:0016887; GO:0032991; GO:0046677 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:19383799}. +P03817 MIOC_ECOLI Protein MioC mioC yieB b3742 JW3720 yieB mioC 15,808 regulation of cell division [GO:0051302] cytosol [GO:0005829] cytosol [GO:0005829]; FMN binding [GO:0010181]; regulation of cell division [GO:0051302] FMN binding [GO:0010181] GO:0005829; GO:0010181; GO:0051302 +P38051 MENF_ECOLI Isochorismate synthase MenF (EC 5.4.4.2) (Isochorismate hydroxymutase) (Isochorismate mutase) menF yfbA b2265 JW2260 yfbA menF 48,765 menaquinone biosynthetic process [GO:0009234] isochorismate synthase activity [GO:0008909]; magnesium ion binding [GO:0000287]; menaquinone biosynthetic process [GO:0009234] isochorismate synthase activity [GO:0008909]; magnesium ion binding [GO:0000287] GO:0000287; GO:0008909; GO:0009234 +P0A769 MNTH_ECOLI Divalent metal cation transporter MntH mntH yfeP b2392 JW2388 yfeP mntH 44,194 cadmium ion transport [GO:0015691]; cellular response to iron ion [GO:0071281]; cobalt ion transport [GO:0006824]; iron ion transport [GO:0006826]; manganese ion transport [GO:0006828]; metal ion transport [GO:0030001] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cadmium ion transmembrane transporter activity [GO:0015086]; manganese ion transmembrane transporter activity [GO:0005384]; metal ion binding [GO:0046872]; proton transmembrane transporter activity [GO:0015078]; symporter activity [GO:0015293]; uniporter activity [GO:0015292]; cadmium ion transport [GO:0015691]; cellular response to iron ion [GO:0071281]; cobalt ion transport [GO:0006824]; iron ion transport [GO:0006826]; manganese ion transport [GO:0006828]; metal ion transport [GO:0030001] cadmium ion transmembrane transporter activity [GO:0015086]; manganese ion transmembrane transporter activity [GO:0005384]; metal ion binding [GO:0046872]; proton transmembrane transporter activity [GO:0015078]; symporter activity [GO:0015293]; uniporter activity [GO:0015292] GO:0005384; GO:0005886; GO:0006824; GO:0006826; GO:0006828; GO:0015078; GO:0015086; GO:0015292; GO:0015293; GO:0015691; GO:0016021; GO:0030001; GO:0046872; GO:0071281 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00221, ECO:0000269|PubMed:14607838}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00221, ECO:0000269|PubMed:14607838}. +P0A9G8 MODE_ECOLI DNA-binding transcriptional dual regulator ModE modE modR b0761 JW0744 modR modE 28,281 molybdate ion transport [GO:0015689] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; molybdenum ion binding [GO:0030151]; molybdate ion transport [GO:0015689] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; molybdenum ion binding [GO:0030151] GO:0003677; GO:0003700; GO:0005829; GO:0015689; GO:0030151 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:9210473}. +P76261 PDED_ECOLI Probable cyclic di-GMP phosphodiesterase PdeD (EC 3.1.4.52) pdeD adrB yoaD b1815 JW1804 adrB yoaD pdeD 59,711 cellular response to DNA damage stimulus [GO:0006974] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cyclic-guanylate-specific phosphodiesterase activity [GO:0071111]; cellular response to DNA damage stimulus [GO:0006974] cyclic-guanylate-specific phosphodiesterase activity [GO:0071111] GO:0005886; GO:0006974; GO:0016021; GO:0071111 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P0ABC3 HFLC_ECOLI Modulator of FtsH protease HflC hflC hflA b4175 JW4133 hflA hflC 37,650 negative regulation of catalytic activity [GO:0043086]; regulation of peptidase activity [GO:0052547]; response to heat [GO:0009408] integral component of external side of plasma membrane [GO:0071575]; membrane protein complex [GO:0098796] integral component of external side of plasma membrane [GO:0071575]; membrane protein complex [GO:0098796]; negative regulation of catalytic activity [GO:0043086]; regulation of peptidase activity [GO:0052547]; response to heat [GO:0009408] GO:0009408; GO:0043086; GO:0052547; GO:0071575; GO:0098796 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:8947034}; Single-pass type II membrane protein {ECO:0000269|PubMed:8947034}. +P0A6L9 HSCB_ECOLI Co-chaperone protein HscB (Hsc20) hscB yfhE b2527 JW2511 yfhE hscB 20,138 [2Fe-2S] cluster assembly [GO:0044571]; protein complex oligomerization [GO:0051259]; protein folding [GO:0006457]; protein maturation by iron-sulfur cluster transfer [GO:0097428] cytosol [GO:0005829]; iron-sulfur cluster transfer complex [GO:1990230] cytosol [GO:0005829]; iron-sulfur cluster transfer complex [GO:1990230]; ATPase activator activity [GO:0001671]; chaperone binding [GO:0051087]; [2Fe-2S] cluster assembly [GO:0044571]; protein complex oligomerization [GO:0051259]; protein folding [GO:0006457]; protein maturation by iron-sulfur cluster transfer [GO:0097428] ATPase activator activity [GO:0001671]; chaperone binding [GO:0051087] GO:0001671; GO:0005829; GO:0006457; GO:0044571; GO:0051087; GO:0051259; GO:0097428; GO:1990230 +P69441 KAD_ECOLI Adenylate kinase (AK) (EC 2.7.4.3) (ATP-AMP transphosphorylase) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) adk dnaW plsA b0474 JW0463 dnaW plsA adk 23,586 ADP biosynthetic process [GO:0006172]; AMP salvage [GO:0044209]; nucleoside diphosphate metabolic process [GO:0009132]; nucleoside monophosphate metabolic process [GO:0009123]; purine ribonucleotide interconversion [GO:0015951] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; adenylate kinase activity [GO:0004017]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; nucleoside diphosphate kinase activity [GO:0004550]; ADP biosynthetic process [GO:0006172]; AMP salvage [GO:0044209]; nucleoside diphosphate metabolic process [GO:0009132]; nucleoside monophosphate metabolic process [GO:0009123]; purine ribonucleotide interconversion [GO:0015951] adenylate kinase activity [GO:0004017]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; nucleoside diphosphate kinase activity [GO:0004550] GO:0000287; GO:0004017; GO:0004550; GO:0005524; GO:0005737; GO:0005829; GO:0006172; GO:0009123; GO:0009132; GO:0015951; GO:0016208; GO:0044209 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00235}. +P0DPD1 LDRC_ECOLI Small toxic polypeptide LdrC ldrC b4423 JW5959 ldrC 4,014 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:P0DPD0}; Single-pass membrane protein {ECO:0000255}. +P0A9M0 LON_ECOLI Lon protease (EC 3.4.21.53) (ATP-dependent protease La) lon capR deg lopA muc b0439 JW0429 capR deg lopA muc lon 87,438 cellular response to heat [GO:0034605]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; proteolysis [GO:0006508]; response to heat [GO:0009408]; response to X-ray [GO:0010165] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; ATP-dependent peptidase activity [GO:0004176]; ATPase activity [GO:0016887]; DNA binding [GO:0003677]; peptidase activity [GO:0008233]; sequence-specific DNA binding [GO:0043565]; serine-type endopeptidase activity [GO:0004252]; cellular response to heat [GO:0034605]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; proteolysis [GO:0006508]; response to heat [GO:0009408]; response to X-ray [GO:0010165] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; ATP-dependent peptidase activity [GO:0004176]; DNA binding [GO:0003677]; peptidase activity [GO:0008233]; sequence-specific DNA binding [GO:0043565]; serine-type endopeptidase activity [GO:0004252] GO:0003677; GO:0004176; GO:0004252; GO:0005524; GO:0005737; GO:0005829; GO:0006508; GO:0006515; GO:0008233; GO:0009408; GO:0010165; GO:0016887; GO:0034605; GO:0043565 SUBCELLULAR LOCATION: Cytoplasm. +P0ABU0 MENB_ECOLI 1,4-dihydroxy-2-naphthoyl-CoA synthase (DHNA-CoA synthase) (EC 4.1.3.36) menB b2262 JW2257 menB 31,633 menaquinone biosynthetic process [GO:0009234] cytosol [GO:0005829] cytosol [GO:0005829]; 1,4-dihydroxy-2-naphthoyl-CoA synthase activity [GO:0008935]; bicarbonate binding [GO:0071890]; menaquinone biosynthetic process [GO:0009234] 1,4-dihydroxy-2-naphthoyl-CoA synthase activity [GO:0008935]; bicarbonate binding [GO:0071890] GO:0005829; GO:0008935; GO:0009234; GO:0071890 +P12282 MOEB_ECOLI Molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) (MoaD protein adenylase) (Molybdopterin-converting factor subunit 1 adenylase) (Sulfur carrier protein MoaD adenylyltransferase) moeB chlN b0826 JW0810 chlN moeB 26,719 Mo-molybdopterin cofactor biosynthetic process [GO:0006777] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; molybdopterin-synthase adenylyltransferase activity [GO:0061605]; nucleotidyltransferase activity [GO:0016779]; ubiquitin-like modifier activating enzyme activity [GO:0008641]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; molybdopterin-synthase adenylyltransferase activity [GO:0061605]; nucleotidyltransferase activity [GO:0016779]; ubiquitin-like modifier activating enzyme activity [GO:0008641] GO:0005524; GO:0005737; GO:0005829; GO:0006777; GO:0008641; GO:0016779; GO:0046872; GO:0061605 +P0AF01 MODB_ECOLI Molybdenum transport system permease protein ModB modB chlJ b0764 JW0747 chlJ modB 24,939 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; molybdate ion transmembrane transporter activity [GO:0015098] molybdate ion transmembrane transporter activity [GO:0015098] GO:0005886; GO:0005887; GO:0015098 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P69856 NANC_ECOLI Probable N-acetylneuraminic acid outer membrane channel protein NanC (NanR-regulated channel) (Porin NanC) nanC yjhA b4311 JW5778 yjhA nanC 27,888 oligosaccharide transport [GO:0015772] integral component of cell outer membrane [GO:0045203]; pore complex [GO:0046930] integral component of cell outer membrane [GO:0045203]; pore complex [GO:0046930]; oligosaccharide transporting porin activity [GO:0015478]; porin activity [GO:0015288]; sialic acid transmembrane transporter activity [GO:0015136]; oligosaccharide transport [GO:0015772] oligosaccharide transporting porin activity [GO:0015478]; porin activity [GO:0015288]; sialic acid transmembrane transporter activity [GO:0015136] GO:0015136; GO:0015288; GO:0015478; GO:0015772; GO:0045203; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane. +P33920 NDPA_ECOLI Nucleoid-associated protein YejK yejK b2186 JW2174 yejK 37,823 bacterial nucleoid [GO:0043590]; cytoplasm [GO:0005737] bacterial nucleoid [GO:0043590]; cytoplasm [GO:0005737]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; single-stranded RNA binding [GO:0003727] double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; single-stranded RNA binding [GO:0003727] GO:0003690; GO:0003727; GO:0005737; GO:0042802; GO:0043590 SUBCELLULAR LOCATION: Cytoplasm, nucleoid. +P75796 GSIA_ECOLI Glutathione import ATP-binding protein GsiA (EC 7.4.2.10) gsiA yliA b0829 JW5897 yliA gsiA 69,114 peptide transport [GO:0015833] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; peptide transport [GO:0015833] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0005887; GO:0015833; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P06989 HIS2_ECOLI Histidine biosynthesis bifunctional protein HisIE [Includes: Phosphoribosyl-AMP cyclohydrolase (PRA-CH) (EC 3.5.4.19); Phosphoribosyl-ATP pyrophosphatase (PRA-PH) (EC 3.6.1.31)] hisI hisIE b2026 JW2008 hisIE hisI 22,756 histidine biosynthetic process [GO:0000105] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; phosphoribosyl-AMP cyclohydrolase activity [GO:0004635]; phosphoribosyl-ATP diphosphatase activity [GO:0004636]; histidine biosynthetic process [GO:0000105] ATP binding [GO:0005524]; phosphoribosyl-AMP cyclohydrolase activity [GO:0004635]; phosphoribosyl-ATP diphosphatase activity [GO:0004636] GO:0000105; GO:0004635; GO:0004636; GO:0005524; GO:0005829 SUBCELLULAR LOCATION: Cytoplasm. +P39208 IDNK_ECOLI Thermosensitive gluconokinase (EC 2.7.1.12) (Gluconate kinase 1) idnK gntV b4268 JW4225 gntV idnK 21,004 D-gluconate catabolic process [GO:0046177]; D-gluconate metabolic process [GO:0019521]; L-idonate catabolic process [GO:0046183] ATP binding [GO:0005524]; gluconokinase activity [GO:0046316]; D-gluconate catabolic process [GO:0046177]; D-gluconate metabolic process [GO:0019521]; L-idonate catabolic process [GO:0046183] ATP binding [GO:0005524]; gluconokinase activity [GO:0046316] GO:0005524; GO:0019521; GO:0046177; GO:0046183; GO:0046316 +P77247 HXPB_ECOLI Hexitol phosphatase B (2-deoxyglucose-6-phosphate phosphatase) (EC 3.1.3.68) (Mannitol-1-phosphatase) (EC 3.1.3.22) (Sorbitol-6-phosphatase) (EC 3.1.3.50) (Sugar-phosphatase) (EC 3.1.3.23) hxpB yniC b1727 JW1716 yniC hxpB 24,330 carbohydrate metabolic process [GO:0005975] cytosol [GO:0005829] cytosol [GO:0005829]; 2-deoxyglucose-6-phosphatase activity [GO:0003850]; glucose-6-phosphatase activity [GO:0004346]; magnesium ion binding [GO:0000287]; mannitol-1-phosphatase activity [GO:0050084]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; sorbitol-6-phosphatase activity [GO:0050286]; sugar-phosphatase activity [GO:0050308]; carbohydrate metabolic process [GO:0005975] 2-deoxyglucose-6-phosphatase activity [GO:0003850]; glucose-6-phosphatase activity [GO:0004346]; magnesium ion binding [GO:0000287]; mannitol-1-phosphatase activity [GO:0050084]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; sorbitol-6-phosphatase activity [GO:0050286]; sugar-phosphatase activity [GO:0050308] GO:0000287; GO:0003850; GO:0004346; GO:0005829; GO:0005975; GO:0016791; GO:0046872; GO:0050084; GO:0050286; GO:0050308 +P19930 HYAD_ECOLI Hydrogenase 1 maturation protease (EC 3.4.23.-) hyaD b0975 JW0957 hyaD 21,546 cellular protein modification process [GO:0006464]; protein processing [GO:0016485] aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872]; cellular protein modification process [GO:0006464]; protein processing [GO:0016485] aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872] GO:0004175; GO:0004190; GO:0006464; GO:0008047; GO:0016485; GO:0046872 +P19932 HYAF_ECOLI Hydrogenase-1 operon protein HyaF hyaF b0977 JW0959 hyaF 31,431 +P77423 HYFH_ECOLI Hydrogenase-4 component H hyfH b2488 JW2473 hyfH 20,159 aerobic respiration [GO:0009060] plasma membrane respiratory chain complex I [GO:0045272] plasma membrane respiratory chain complex I [GO:0045272]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]; aerobic respiration [GO:0009060] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on NAD(P)H [GO:0016651] GO:0009060; GO:0016651; GO:0045272; GO:0046872; GO:0051539 +P0AEW9 K1PF_ECOLI 1-phosphofructokinase (EC 2.7.1.56) (Fructose 1-phosphate kinase) fruK fpk b2168 JW2155 fpk fruK 33,756 fructose catabolic process [GO:0006001] cytosol [GO:0005829] cytosol [GO:0005829]; 1-phosphofructokinase activity [GO:0008662]; ATP binding [GO:0005524]; phosphofructokinase activity [GO:0008443]; fructose catabolic process [GO:0006001] 1-phosphofructokinase activity [GO:0008662]; ATP binding [GO:0005524]; phosphofructokinase activity [GO:0008443] GO:0005524; GO:0005829; GO:0006001; GO:0008443; GO:0008662 +P0CF08 INSA2_ECOLI Insertion element IS1 2 protein InsA (IS1b) insA2 b0265 JW0257 insA2 9,902 transposition, DNA-mediated [GO:0006313] transposition, DNA-mediated [GO:0006313] GO:0006313 +P0CF28 INSB5_ECOLI Insertion element IS1 5 protein InsB (IS1h) insB5 b1893 insB5 19,565 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CF79 INSF1_ECOLI Transposase InsF for insertion sequence IS3A insF1 b0299 JW0293 insF1 33,540 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0032196 +Q6BF25 LDRD_ECOLI Small toxic polypeptide LdrD ldrD b4453 JW5966 ldrD 3,917 cell death [GO:0008219] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cell death [GO:0008219] GO:0005886; GO:0008219; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. +P18811 MALI_ECOLI Maltose regulon regulatory protein MalI malI b1620 JW1612 malI 36,625 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] protein-DNA complex [GO:0032993] protein-DNA complex [GO:0032993]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity [GO:0001217]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity [GO:0001217]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0001217; GO:0003700; GO:0006355; GO:0032993; GO:0045892 +P19636 EUTC_ECOLI Ethanolamine ammonia-lyase small subunit (EAL small subunit) (EC 4.3.1.7) (Ethanolamine ammonia-lyase beta subunit) (Ethanolamine ammonia-lyase light chain) (Ethanolamine deaminase small subunit) eutC b2440 JW2433 eutC 31,782 cellular amino acid metabolic process [GO:0006520]; ethanolamine catabolic process [GO:0046336] ethanolamine ammonia-lyase complex [GO:0009350] ethanolamine ammonia-lyase complex [GO:0009350]; cobalamin binding [GO:0031419]; ethanolamine ammonia-lyase activity [GO:0008851]; cellular amino acid metabolic process [GO:0006520]; ethanolamine catabolic process [GO:0046336] cobalamin binding [GO:0031419]; ethanolamine ammonia-lyase activity [GO:0008851] GO:0006520; GO:0008851; GO:0009350; GO:0031419; GO:0046336 SUBCELLULAR LOCATION: Bacterial microcompartment {ECO:0000255|HAMAP-Rule:MF_00601}. +P69902 FCTA_ECOLI Formyl-CoA:oxalate CoA-transferase (FCOCT) (EC 2.8.3.16) (Formyl-coenzyme A transferase) (Formyl-CoA transferase) frc yfdW b2374 JW2371 yfdW frc 45,828 cellular response to acidic pH [GO:0071468]; oxalate catabolic process [GO:0033611] formyl-CoA transferase activity [GO:0033608]; cellular response to acidic pH [GO:0071468]; oxalate catabolic process [GO:0033611] formyl-CoA transferase activity [GO:0033608] GO:0033608; GO:0033611; GO:0071468 +P07658 FDHF_ECOLI Formate dehydrogenase H (EC 1.17.98.4) (Formate dehydrogenase-H subunit alpha) (FDH-H) (Formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide) fdhF b4079 JW4040 fdhF 79,374 cellular respiration [GO:0045333]; formate oxidation [GO:0015944]; urate catabolic process [GO:0019628] cytosol [GO:0005829]; plasma membrane respiratory chain complex I [GO:0045272] cytosol [GO:0005829]; plasma membrane respiratory chain complex I [GO:0045272]; 4 iron, 4 sulfur cluster binding [GO:0051539]; formate dehydrogenase (NAD+) activity [GO:0008863]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; cellular respiration [GO:0045333]; formate oxidation [GO:0015944]; urate catabolic process [GO:0019628] 4 iron, 4 sulfur cluster binding [GO:0051539]; formate dehydrogenase (NAD+) activity [GO:0008863]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546] GO:0005829; GO:0008863; GO:0015944; GO:0019628; GO:0030151; GO:0043546; GO:0045272; GO:0045333; GO:0051539 +P28861 FENR_ECOLI Flavodoxin/ferredoxin--NADP reductase (EC 1.18.1.2) (EC 1.19.1.1) (Ferredoxin (flavodoxin):NADP(+) oxidoreductase) (Ferredoxin--NADP reductase) (FNR) (Flavodoxin--NADP reductase) (FLDR) (Methyl viologen resistance protein A) (dA1) fpr mvrA b3924 JW3895 mvrA fpr 27,751 iron-sulfur cluster assembly [GO:0016226]; response to drug [GO:0042493]; response to superoxide [GO:0000303] cytosol [GO:0005829] cytosol [GO:0005829]; FAD binding [GO:0071949]; ferredoxin-NADP+ reductase activity [GO:0004324]; iron-sulfur cluster assembly [GO:0016226]; response to drug [GO:0042493]; response to superoxide [GO:0000303] FAD binding [GO:0071949]; ferredoxin-NADP+ reductase activity [GO:0004324] GO:0000303; GO:0004324; GO:0005829; GO:0016226; GO:0042493; GO:0071949 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7961651}. +P77279 FETA_ECOLI Probable iron export ATP-binding protein FetA (EC 7.2.2.-) fetA ybbL b0490 JW0479 ybbL fetA 25,382 cellular iron ion homeostasis [GO:0006879]; phosphate ion transmembrane transport [GO:0035435] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; inorganic phosphate transmembrane transporter activity [GO:0005315]; cellular iron ion homeostasis [GO:0006879]; phosphate ion transmembrane transport [GO:0035435] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; inorganic phosphate transmembrane transporter activity [GO:0005315] GO:0005315; GO:0005524; GO:0005886; GO:0006879; GO:0035435; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. +P06972 FHUB_ECOLI Iron(3+)-hydroxamate import system permease protein FhuB (Ferric hydroxamate uptake protein B) (Ferrichrome transport system permease protein FhuB) (Ferrichrome uptake protein FhuB) (Iron(III)-hydroxamate import system permease protein FhuB) fhuB b0153 JW0149 fhuB 70,423 siderophore-dependent iron import into cell [GO:0033214] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; siderophore-dependent iron import into cell [GO:0033214] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0022857; GO:0033214; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:15919996}. +P23485 FECR_ECOLI Protein FecR fecR b4292 JW4252 fecR 35,532 ion transport [GO:0006811]; iron ion homeostasis [GO:0055072]; response to stimulus [GO:0050896] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; sigma factor antagonist activity [GO:0016989]; ion transport [GO:0006811]; iron ion homeostasis [GO:0055072]; response to stimulus [GO:0050896] sigma factor antagonist activity [GO:0016989] GO:0006811; GO:0016989; GO:0042597; GO:0050896; GO:0055072 SUBCELLULAR LOCATION: Periplasm. +P39829 GARD_ECOLI Galactarate dehydratase (L-threo-forming) (GalcD) (EC 4.2.1.42) garD yhaG b3128 JW3097 yhaG garD 56,402 D-galacturonate catabolic process [GO:0019698]; galactarate catabolic process [GO:0046392] galactarate dehydratase activity [GO:0008867]; metal ion binding [GO:0046872]; D-galacturonate catabolic process [GO:0019698]; galactarate catabolic process [GO:0046392] galactarate dehydratase activity [GO:0008867]; metal ion binding [GO:0046872] GO:0008867; GO:0019698; GO:0046392; GO:0046872 +P32152 FRVR_ECOLI Putative frv operon regulatory protein [Includes: Putative phosphotransferase EIIA component (EC 2.7.1.-) (Putative PTS system EIIA component)] frvR yiiH b3897 JW3868 yiiH frvR 66,000 DNA binding [GO:0003677]; kinase activity [GO:0016301] DNA binding [GO:0003677]; kinase activity [GO:0016301] GO:0003677; GO:0016301 +P0AFS3 FOLM_ECOLI Dihydromonapterin reductase (H(2)-MPt reductase) (EC 1.5.1.50) (Dihydrofolate reductase) (DHFR) (EC 1.5.1.3) folM ydgB b1606 JW1598 ydgB folM 26,348 one-carbon metabolic process [GO:0006730] dihydrofolate reductase activity [GO:0004146]; dihydromonapterin reductase activity [GO:0071172]; one-carbon metabolic process [GO:0006730] dihydrofolate reductase activity [GO:0004146]; dihydromonapterin reductase activity [GO:0071172] GO:0004146; GO:0006730; GO:0071172 +P37747 GLF_ECOLI UDP-galactopyranose mutase (UGM) (EC 5.4.99.9) (UDP-GALP mutase) (Uridine 5-diphosphate galactopyranose mutase) glf yefE b2036 JW2021 yefE glf 42,966 lipopolysaccharide biosynthetic process [GO:0009103] cytosol [GO:0005829] cytosol [GO:0005829]; flavin adenine dinucleotide binding [GO:0050660]; UDP-galactopyranose mutase activity [GO:0008767]; lipopolysaccharide biosynthetic process [GO:0009103] flavin adenine dinucleotide binding [GO:0050660]; UDP-galactopyranose mutase activity [GO:0008767] GO:0005829; GO:0008767; GO:0009103; GO:0050660 +P0C8J6 GATY_ECOLI D-tagatose-1,6-bisphosphate aldolase subunit GatY (TBPA) (TagBP aldolase) (EC 4.1.2.40) (D-tagatose-bisphosphate aldolase class II) (Tagatose-bisphosphate aldolase) gatY yegF b2096 JW5343 yegF gatY 30,812 D-tagatose 6-phosphate catabolic process [GO:2001059]; galactitol catabolic process [GO:0019404] cytosol [GO:0005829] cytosol [GO:0005829]; tagatose-bisphosphate aldolase activity [GO:0009025]; zinc ion binding [GO:0008270]; D-tagatose 6-phosphate catabolic process [GO:2001059]; galactitol catabolic process [GO:0019404] tagatose-bisphosphate aldolase activity [GO:0009025]; zinc ion binding [GO:0008270] GO:0005829; GO:0008270; GO:0009025; GO:0019404; GO:2001059 +P37902 GLTI_ECOLI Glutamate/aspartate import solute-binding protein gltI ybeJ yzzK b0655 JW5092 ybeJ yzzK gltI 33,420 L-aspartate transmembrane transport [GO:0070778]; L-glutamate transmembrane transport [GO:0015813] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; aspartate binding [GO:0070335]; glutamate binding [GO:0016595]; L-aspartate transmembrane transport [GO:0070778]; L-glutamate transmembrane transport [GO:0015813] aspartate binding [GO:0070335]; glutamate binding [GO:0016595] GO:0015813; GO:0016595; GO:0030288; GO:0070335; GO:0070778 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:1091635}. +P45761 GSPJ_ECOLI Type II secretion system protein J (T2SS protein J) (Putative general secretion pathway protein J) gspJ yheI b3331 JW3293 yheI gspJ 22,231 protein secretion by the type II secretion system [GO:0015628] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627]; protein secretion by the type II secretion system [GO:0015628] GO:0005886; GO:0015627; GO:0015628; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:Q00517}; Single-pass membrane protein {ECO:0000255}. +P45758 GSPD_ECOLI Putative secretin GspD (Putative general secretion pathway protein D) (Putative type II secretion system protein D) (T2SS protein D) gspD yheF b3325 JW5707 yheF gspD 70,698 protein secretion [GO:0009306]; protein secretion by the type II secretion system [GO:0015628] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; type II protein secretion system complex [GO:0015627] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; type II protein secretion system complex [GO:0015627]; identical protein binding [GO:0042802]; protein secretion [GO:0009306]; protein secretion by the type II secretion system [GO:0015628] identical protein binding [GO:0042802] GO:0009279; GO:0009306; GO:0015627; GO:0015628; GO:0016021; GO:0042802 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305|PubMed:28067918}. Note=Most of the protein is in the periplasm which it traverses to contact proteins of the cell inner membrane. {ECO:0000305|PubMed:28067918}. +Q46916 GUDP_ECOLI Probable glucarate transporter (D-glucarate permease) gudP ygcZ b2789 JW2760 ygcZ gudP 49,142 D-glucarate metabolic process [GO:0042836]; galactarate metabolic process [GO:0019580]; inorganic anion transport [GO:0015698] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; D-glucarate metabolic process [GO:0042836]; galactarate metabolic process [GO:0019580]; inorganic anion transport [GO:0015698] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0015698; GO:0016021; GO:0019580; GO:0022857; GO:0042836 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P03959 KDPA_ECOLI Potassium-transporting ATPase potassium-binding subunit (ATP phosphohydrolase [potassium-transporting] A chain) (Potassium-binding and translocating subunit A) (Potassium-translocating ATPase A chain) kdpA b0698 JW0686 kdpA 59,189 cation transmembrane transport [GO:0098655]; potassium ion transmembrane transport [GO:0071805] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; potassium ion-transporting ATPase complex [GO:0031004]; P-type potassium transmembrane transporter activity [GO:0008556]; potassium ion binding [GO:0030955]; cation transmembrane transport [GO:0098655]; potassium ion transmembrane transport [GO:0071805] potassium ion binding [GO:0030955]; P-type potassium transmembrane transporter activity [GO:0008556] GO:0005886; GO:0005887; GO:0008556; GO:0030955; GO:0031004; GO:0071805; GO:0098655 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00275, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2849541, ECO:0000269|PubMed:7896809}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00275, ECO:0000269|PubMed:7896809}. +P21866 KDPE_ECOLI KDP operon transcriptional regulatory protein KdpE kdpE b0694 JW5096 kdpE 25,362 regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000976; GO:0000986; GO:0001216; GO:0003700; GO:0005829; GO:0006355; GO:0032993 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1532388}. +P0AC75 KDTA_ECOLI 3-deoxy-D-manno-octulosonic acid transferase (Kdo transferase) (EC 2.4.99.12) (EC 2.4.99.13) (Bifunctional Kdo transferase) (Kdo-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase) (Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase) waaA kdtA b3633 JW3608 kdtA waaA 47,291 Kdo2-lipid A biosynthetic process [GO:0036104]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide core region biosynthetic process [GO:0009244] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; Kdo transferase activity [GO:0043842]; transferase activity [GO:0016740]; Kdo2-lipid A biosynthetic process [GO:0036104]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide core region biosynthetic process [GO:0009244] Kdo transferase activity [GO:0043842]; transferase activity [GO:0016740] GO:0005886; GO:0009244; GO:0009245; GO:0016020; GO:0016021; GO:0016740; GO:0036104; GO:0043842 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:1577828}; Single-pass membrane protein {ECO:0000305|PubMed:1577828}; Cytoplasmic side {ECO:0000305|PubMed:1577828}. +P09151 LEU1_ECOLI 2-isopropylmalate synthase (EC 2.3.3.13) (Alpha-IPM synthase) (Alpha-isopropylmalate synthase) leuA b0074 JW0073 leuA 57,298 branched-chain amino acid biosynthetic process [GO:0009082]; leucine biosynthetic process [GO:0009098] cytosol [GO:0005829] cytosol [GO:0005829]; 2-isopropylmalate synthase activity [GO:0003852]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; branched-chain amino acid biosynthetic process [GO:0009082]; leucine biosynthetic process [GO:0009098] 2-isopropylmalate synthase activity [GO:0003852]; acetyl-CoA C-acetyltransferase activity [GO:0003985] GO:0003852; GO:0003985; GO:0005829; GO:0009082; GO:0009098 +P24200 MCRA_ECOLI 5-methylcytosine-specific restriction enzyme A (EC 3.1.21.-) (EcoKMcrA) mcrA rglA b1159 JW1145 rglA mcrA 31,390 DNA restriction-modification system [GO:0009307] endonuclease activity [GO:0004519]; methyl-CpG binding [GO:0008327]; DNA restriction-modification system [GO:0009307] endonuclease activity [GO:0004519]; methyl-CpG binding [GO:0008327] GO:0004519; GO:0008327; GO:0009307 +P23876 FEPD_ECOLI Ferric enterobactin transport system permease protein FepD fepD b0590 JW0582 fepD 33,871 ferric-enterobactin import into cell [GO:0015685]; siderophore-dependent iron import into cell [GO:0033214] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ferric-enterobactin transmembrane transporter activity [GO:0015620]; transmembrane transporter activity [GO:0022857]; ferric-enterobactin import into cell [GO:0015685]; siderophore-dependent iron import into cell [GO:0033214] ferric-enterobactin transmembrane transporter activity [GO:0015620]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0015620; GO:0015685; GO:0022857; GO:0033214 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P52612 FLII_ECOLI Flagellum-specific ATP synthase (EC 7.1.2.2) fliI fla AIII flaC b1941 JW1925 fla AIII flaC fliI 49,316 bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973]; protein secretion by the type III secretion system [GO:0030254] cytoplasm [GO:0005737]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; type III protein secretion system complex [GO:0030257] cytoplasm [GO:0005737]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; type III protein secretion system complex [GO:0030257]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973]; protein secretion by the type III secretion system [GO:0030254] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933] GO:0005524; GO:0005737; GO:0030254; GO:0030257; GO:0042802; GO:0044780; GO:0045261; GO:0046933; GO:0046961; GO:0071973 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AEM6 FLIA_ECOLI RNA polymerase sigma factor FliA (RNA polymerase sigma factor for flagellar operon) (Sigma F) (Sigma-27) (Sigma-28) fliA flaD rpoF b1922 JW1907 flaD rpoF fliA 27,521 regulation of transcription, DNA-templated [GO:0006355]; transcription initiation from bacterial-type RNA polymerase promoter [GO:0001123] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; sigma factor activity [GO:0016987]; regulation of transcription, DNA-templated [GO:0006355]; transcription initiation from bacterial-type RNA polymerase promoter [GO:0001123] DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; sigma factor activity [GO:0016987] GO:0001123; GO:0003677; GO:0003899; GO:0005829; GO:0006355; GO:0016987 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00962}. +P13039 FES_ECOLI Iron(III) enterobactin esterase (EC 3.1.1.108) (Enterochelin esterase) (Ferric enterobactin esterase) fes b0585 JW0576 fes 45,652 enterobactin catabolic process [GO:0046214]; siderophore-dependent iron import into cell [GO:0033214] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; enterochelin esterase activity [GO:0008849]; iron ion binding [GO:0005506]; enterobactin catabolic process [GO:0046214]; siderophore-dependent iron import into cell [GO:0033214] enterochelin esterase activity [GO:0008849]; iron ion binding [GO:0005506] GO:0005506; GO:0005737; GO:0008849; GO:0033214; GO:0046214 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:1534808}. +P15028 FECB_ECOLI Fe(3+) dicitrate-binding periplasmic protein (Iron(III) dicitrate-binding periplasmic protein) fecB b4290 JW4250 fecB 33,146 iron ion homeostasis [GO:0055072]; response to iron ion [GO:0010039]; siderophore-dependent iron import into cell [GO:0033214] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; iron ion homeostasis [GO:0055072]; response to iron ion [GO:0010039]; siderophore-dependent iron import into cell [GO:0033214] GO:0010039; GO:0030288; GO:0033214; GO:0055072 SUBCELLULAR LOCATION: Periplasm. +P31697 FIMC_ECOLI Chaperone protein FimC fimC b4316 JW4279 fimC 26,689 cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; protein folding chaperone [GO:0044183]; cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] protein folding chaperone [GO:0044183] GO:0030288; GO:0043711; GO:0044183; GO:0061077; GO:0071555 SUBCELLULAR LOCATION: Periplasm. +P0A9B2 G3P1_ECOLI Glyceraldehyde-3-phosphate dehydrogenase A (GAPDH-A) (EC 1.2.1.12) (NAD-dependent glyceraldehyde-3-phosphate dehydrogenase) gapA b1779 JW1768 gapA 35,532 glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [GO:0004365]; NAD binding [GO:0051287]; NADP binding [GO:0050661] GO:0004365; GO:0005829; GO:0006006; GO:0006096; GO:0016020; GO:0050661; GO:0051287 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P75883 GFCC_ECOLI Uncharacterized protein GfcC (Group 4 capsule protein C homolog) gfcC ymcB b0985 JW0968 ymcB gfcC 27,296 +P21345 GLTP_ECOLI Proton/glutamate-aspartate symporter (Glutamate-aspartate carrier protein) (Proton-glutamate-aspartate transport protein) gltP b4077 JW4038 gltP 47,159 dicarboxylic acid transport [GO:0006835] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; amino acid:proton symporter activity [GO:0005280]; transmembrane transporter activity [GO:0022857]; dicarboxylic acid transport [GO:0006835] amino acid:proton symporter activity [GO:0005280]; transmembrane transporter activity [GO:0022857] GO:0005280; GO:0005886; GO:0006835; GO:0016020; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02063, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:1971622, ECO:0000269|PubMed:2537813}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02063}. +P77293 GTRB_ECOLI Prophage bactoprenol glucosyl transferase homolog (EC 2.4.1.-) (Bactoprenol glucosyl transferase homolog from prophage CPS-53) yfdH b2351 JW2347 yfdH 34,635 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transferase activity, transferring glycosyl groups [GO:0016757] transferase activity, transferring glycosyl groups [GO:0016757] GO:0005886; GO:0016021; GO:0016757 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76641 GUAD_ECOLI Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) guaD ygfP b2883 JW5466 ygfP guaD 50,244 guanine catabolic process [GO:0006147]; guanine metabolic process [GO:0046098] cytosol [GO:0005829] cytosol [GO:0005829]; ammeline aminohydrolase activity [GO:0018756]; deaminase activity [GO:0019239]; guanine deaminase activity [GO:0008892]; zinc ion binding [GO:0008270]; guanine catabolic process [GO:0006147]; guanine metabolic process [GO:0046098] ammeline aminohydrolase activity [GO:0018756]; deaminase activity [GO:0019239]; guanine deaminase activity [GO:0008892]; zinc ion binding [GO:0008270] GO:0005829; GO:0006147; GO:0008270; GO:0008892; GO:0018756; GO:0019239; GO:0046098 +P76141 LSRR_ECOLI Transcriptional regulator LsrR lsrR ydeW b1512 JW1505 ydeW lsrR 33,797 regulation of DNA-templated transcription, initiation [GO:2000142]; response to heat [GO:0009408]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829] cytosol [GO:0005829]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; regulation of DNA-templated transcription, initiation [GO:2000142]; response to heat [GO:0009408]; transcription, DNA-templated [GO:0006351] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802] GO:0000986; GO:0005829; GO:0006351; GO:0009408; GO:0030246; GO:0042802; GO:2000142 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P39196 LPLT_ECOLI Lysophospholipid transporter LplT lplT ygeD b2835 JW2803 ygeD lplT 41,656 glycerophospholipid metabolic process [GO:0006650] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; lysophospholipid:sodium symporter activity [GO:0051978]; glycerophospholipid metabolic process [GO:0006650] lysophospholipid:sodium symporter activity [GO:0051978] GO:0005886; GO:0005887; GO:0006650; GO:0051978 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P60995 LPHI_ECOLI his operon leader peptide (his operon attenuator peptide) hisL b2018 JW2000 hisL 2,081 histidine biosynthetic process [GO:0000105] histidine biosynthetic process [GO:0000105] GO:0000105 +P69741 MBHT_ECOLI Hydrogenase-2 small chain (HYD2) (EC 1.12.99.6) (Membrane-bound hydrogenase 2 small subunit) (NiFe hydrogenase) hybO yghV b2997 JW2965 yghV hybO 39,652 anaerobic respiration [GO:0009061] [Ni-Fe] hydrogenase complex [GO:0044569]; extrinsic component of periplasmic side of plasma membrane [GO:0031236]; ferredoxin hydrogenase complex [GO:0009375]; membrane [GO:0016020]; periplasmic space [GO:0042597] [Ni-Fe] hydrogenase complex [GO:0044569]; extrinsic component of periplasmic side of plasma membrane [GO:0031236]; ferredoxin hydrogenase complex [GO:0009375]; membrane [GO:0016020]; periplasmic space [GO:0042597]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; ferredoxin hydrogenase activity [GO:0008901]; hydrogenase (acceptor) activity [GO:0033748]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; anaerobic respiration [GO:0009061] 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; ferredoxin hydrogenase activity [GO:0008901]; hydrogenase (acceptor) activity [GO:0033748]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872] GO:0008901; GO:0009055; GO:0009061; GO:0009375; GO:0016020; GO:0031236; GO:0033748; GO:0042597; GO:0044569; GO:0046872; GO:0051536; GO:0051538; GO:0051539 SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Periplasmic side. Periplasm. +P76159 LYSQ_ECOLI Probable prophage lysozyme (EC 3.2.1.17) (Endolysin) (Lysis protein) (Muramidase) (Probable lysozyme from lambdoid prophage Qin) rrrQ arrQ ydfQ b1554 JW1546 arrQ ydfQ rrrQ 19,663 cell wall macromolecule catabolic process [GO:0016998]; cytolysis [GO:0019835]; defense response to bacterium [GO:0042742]; peptidoglycan catabolic process [GO:0009253] lysozyme activity [GO:0003796]; cell wall macromolecule catabolic process [GO:0016998]; cytolysis [GO:0019835]; defense response to bacterium [GO:0042742]; peptidoglycan catabolic process [GO:0009253] lysozyme activity [GO:0003796] GO:0003796; GO:0009253; GO:0016998; GO:0019835; GO:0042742 +P24175 MANB_ECOLI Phosphomannomutase (PMM) (EC 5.4.2.8) manB cpsG rfbL b2048 JW2033 cpsG rfbL manB 50,463 GDP-mannose biosynthetic process [GO:0009298]; lipopolysaccharide biosynthetic process [GO:0009103] magnesium ion binding [GO:0000287]; phosphomannomutase activity [GO:0004615]; GDP-mannose biosynthetic process [GO:0009298]; lipopolysaccharide biosynthetic process [GO:0009103] magnesium ion binding [GO:0000287]; phosphomannomutase activity [GO:0004615] GO:0000287; GO:0004615; GO:0009103; GO:0009298 +P07623 METAS_ECOLI Homoserine O-succinyltransferase (HST) (EC 2.3.1.46) (Homoserine transsuccinylase) (HTS) metAS metA b4013 JW3973 metA metAS 35,727 L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine [GO:0019281] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; homoserine O-acetyltransferase activity [GO:0004414]; homoserine O-succinyltransferase activity [GO:0008899]; L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine [GO:0019281] homoserine O-acetyltransferase activity [GO:0004414]; homoserine O-succinyltransferase activity [GO:0008899] GO:0004414; GO:0005737; GO:0008899; GO:0019281 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00295, ECO:0000305}. +P0AEZ1 METF_ECOLI 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) metF b3941 JW3913 metF 33,103 methionine biosynthetic process [GO:0009086]; tetrahydrofolate biosynthetic process [GO:0046654]; tetrahydrofolate interconversion [GO:0035999] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; FAD binding [GO:0071949]; methylenetetrahydrofolate reductase (NAD(P)H) activity [GO:0004489]; methylenetetrahydrofolate reductase NADH activity [GO:0106312]; methylenetetrahydrofolate reductase NADPH activity [GO:0106313]; methionine biosynthetic process [GO:0009086]; tetrahydrofolate biosynthetic process [GO:0046654]; tetrahydrofolate interconversion [GO:0035999] FAD binding [GO:0071949]; methylenetetrahydrofolate reductase (NAD(P)H) activity [GO:0004489]; methylenetetrahydrofolate reductase NADH activity [GO:0106312]; methylenetetrahydrofolate reductase NADPH activity [GO:0106313] GO:0004489; GO:0005829; GO:0009086; GO:0032991; GO:0035999; GO:0046654; GO:0071949; GO:0106312; GO:0106313 +P18196 MINC_ECOLI Septum site-determining protein MinC minC b1176 JW1165 minC 24,776 cell division [GO:0051301]; cell morphogenesis [GO:0000902]; division septum assembly [GO:0000917]; regulation of cell division [GO:0051302]; regulation of division septum assembly [GO:0032955] cell pole [GO:0060187]; cytosol [GO:0005829] cell pole [GO:0060187]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; cell division [GO:0051301]; cell morphogenesis [GO:0000902]; division septum assembly [GO:0000917]; regulation of cell division [GO:0051302]; regulation of division septum assembly [GO:0032955] identical protein binding [GO:0042802] GO:0000902; GO:0000917; GO:0005829; GO:0032955; GO:0042802; GO:0051301; GO:0051302; GO:0060187 +Q46865 MQSR_ECOLI mRNA interferase toxin MqsR (EC 3.1.-.-) (Endoribonuclease MqsR) (Motility quorum-sensing regulator MqsR) (Toxin MqsR) mqsR ygiU b3022 JW2990 ygiU mqsR 11,232 negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation [GO:0017148]; quorum sensing [GO:0009372]; regulation of cell motility [GO:2000145]; regulation of mRNA stability [GO:0043488]; single-species biofilm formation [GO:0044010] endoribonuclease activity [GO:0004521]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation [GO:0017148]; quorum sensing [GO:0009372]; regulation of cell motility [GO:2000145]; regulation of mRNA stability [GO:0043488]; single-species biofilm formation [GO:0044010] endoribonuclease activity [GO:0004521] GO:0004521; GO:0009372; GO:0017148; GO:0043488; GO:0044010; GO:0045892; GO:2000145 +P30745 MOAA_ECOLI GTP 3',8-cyclase (EC 4.1.99.22) (Molybdenum cofactor biosynthesis protein A) moaA bisA chlA chlA1 narA b0781 JW0764 bisA chlA chlA1 narA moaA 37,346 Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; response to heat [GO:0009408] molybdopterin synthase complex [GO:0019008] molybdopterin synthase complex [GO:0019008]; 4 iron, 4 sulfur cluster binding [GO:0051539]; GTP 3',8'-cyclase activity [GO:0061798]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; response to heat [GO:0009408] 4 iron, 4 sulfur cluster binding [GO:0051539]; GTP 3',8'-cyclase activity [GO:0061798]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047] GO:0005525; GO:0006777; GO:0009408; GO:0019008; GO:0046872; GO:0051539; GO:0061798; GO:1904047 +P75825 HCP_ECOLI Hydroxylamine reductase (EC 1.7.99.1) (Hybrid-cluster protein) (HCP) (Prismane protein) hcp ybjW b0873 JW0857 ybjW hcp 60,064 nitric oxide catabolic process [GO:0046210]; nitrogen compound metabolic process [GO:0006807]; peptidyl-cysteine S-nitrosylation [GO:0018119]; peptidyl-cysteine S-trans-nitrosylation [GO:0035606]; response to hydrogen peroxide [GO:0042542] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 2 iron, 2 sulfur cluster binding [GO:0051537]; hydroxylamine reductase activity [GO:0050418]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; peroxidase activity [GO:0004601]; nitric oxide catabolic process [GO:0046210]; nitrogen compound metabolic process [GO:0006807]; peptidyl-cysteine S-nitrosylation [GO:0018119]; peptidyl-cysteine S-trans-nitrosylation [GO:0035606]; response to hydrogen peroxide [GO:0042542] 2 iron, 2 sulfur cluster binding [GO:0051537]; hydroxylamine reductase activity [GO:0050418]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; peroxidase activity [GO:0004601] GO:0004601; GO:0005737; GO:0006807; GO:0016491; GO:0018119; GO:0035606; GO:0042542; GO:0046210; GO:0046872; GO:0050418; GO:0051537 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00069}. +P0ACB2 HEM2_ECOLI Delta-aminolevulinic acid dehydratase (ALAD) (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase) hemB ncf b0369 JW0361 ncf hemB 35,625 heme biosynthetic process [GO:0006783]; protoporphyrinogen IX biosynthetic process [GO:0006782] cytosol [GO:0005829] cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; porphobilinogen synthase activity [GO:0004655]; zinc ion binding [GO:0008270]; heme biosynthetic process [GO:0006783]; protoporphyrinogen IX biosynthetic process [GO:0006782] magnesium ion binding [GO:0000287]; porphobilinogen synthase activity [GO:0004655]; zinc ion binding [GO:0008270] GO:0000287; GO:0004655; GO:0005829; GO:0006782; GO:0006783; GO:0008270 +P76056 INTR_ECOLI Prophage integrase IntR (Putative lambdoid prophage Rac integrase) intR ydaP b1345 JW1339 ydaP intR 47,539 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0044826; GO:0046718; GO:0075713 +P62620 ISPG_ECOLI 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (EC 1.17.7.3) (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase) (Protein GcpE) (Protein E) ispG gcpE b2515 JW2499 gcpE ispG 40,684 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; terpenoid biosynthetic process [GO:0016114] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity [GO:0046429]; iron ion binding [GO:0005506]; metal ion binding [GO:0046872]; isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; terpenoid biosynthetic process [GO:0016114] 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity [GO:0046429]; 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; metal ion binding [GO:0046872] GO:0005506; GO:0005829; GO:0016114; GO:0019288; GO:0046429; GO:0046872; GO:0051539 +P0CF58 INSD6_ECOLI Transposase InsD for insertion element IS2K insD6 b4273 JW4230 insD6 34,398 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0032196 +P75981 JAYE_ECOLI Putative protein JayE (Putative protein JayE from lambdoid prophage e14 region) jayE ymfP b1152 JW5170 ymfP jayE 28,233 +P30192 INSZ_ECOLI Putative transposase InsZ insZ ychG b4573 JW1227/JW5883 b1239/b1240 ychG insZ 33,808 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0A720 KTHY_ECOLI Thymidylate kinase (EC 2.7.4.9) (Thymidine monophosphate kinase) (dTMP kinase) (TMPK) tmk ycfG b1098 JW1084 ycfG tmk 23,783 dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]; dUDP biosynthetic process [GO:0006227]; nucleobase-containing small molecule interconversion [GO:0015949] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; thymidylate kinase activity [GO:0004798]; uridylate kinase activity [GO:0009041]; dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]; dUDP biosynthetic process [GO:0006227]; nucleobase-containing small molecule interconversion [GO:0015949] ATP binding [GO:0005524]; thymidylate kinase activity [GO:0004798]; uridylate kinase activity [GO:0009041] GO:0004798; GO:0005524; GO:0005737; GO:0005829; GO:0006227; GO:0006233; GO:0006235; GO:0009041; GO:0015949 +P39398 LGOT_ECOLI Probable L-galactonate transporter (Galactonate:H(+) symporter) lgoT yjiZ yjjL b4356 JW4319 yjiZ yjjL lgoT 49,440 aldonate transmembrane transport [GO:0042873]; carbohydrate transport [GO:0008643] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; aldonate transmembrane transport [GO:0042873]; carbohydrate transport [GO:0008643] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0008643; GO:0016021; GO:0022857; GO:0042873 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P75823 LTAE_ECOLI Low specificity L-threonine aldolase (Low specificity L-TA) (EC 4.1.2.48) ltaE ybjU b0870 JW0854 ybjU ltaE 36,495 glycine biosynthetic process [GO:0006545]; threonine catabolic process [GO:0006567] cytosol [GO:0005829] cytosol [GO:0005829]; identical protein binding [GO:0042802]; L-allo-threonine aldolase activity [GO:0008732]; phenylserine aldolase activity [GO:0050179]; pyridoxal phosphate binding [GO:0030170]; glycine biosynthetic process [GO:0006545]; threonine catabolic process [GO:0006567] identical protein binding [GO:0042802]; L-allo-threonine aldolase activity [GO:0008732]; phenylserine aldolase activity [GO:0050179]; pyridoxal phosphate binding [GO:0030170] GO:0005829; GO:0006545; GO:0006567; GO:0008732; GO:0030170; GO:0042802; GO:0050179 +P10441 LPXB_ECOLI Lipid-A-disaccharide synthase (EC 2.4.1.182) lpxB pgsB b0182 JW0177 pgsB lpxB 42,382 lipid A biosynthetic process [GO:0009245] cytoplasm [GO:0005737]; extrinsic component of plasma membrane [GO:0019897] cytoplasm [GO:0005737]; extrinsic component of plasma membrane [GO:0019897]; identical protein binding [GO:0042802]; lipid-A-disaccharide synthase activity [GO:0008915]; phospholipid binding [GO:0005543]; lipid A biosynthetic process [GO:0009245] identical protein binding [GO:0042802]; lipid-A-disaccharide synthase activity [GO:0008915]; phospholipid binding [GO:0005543] GO:0005543; GO:0005737; GO:0008915; GO:0009245; GO:0019897; GO:0042802 +P13009 METH_ECOLI Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Methionine synthase, vitamin-B12-dependent) (MS) metH b4019 JW3979 metH 135,997 homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; methylation [GO:0032259]; tetrahydrofolate interconversion [GO:0035999] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cobalamin binding [GO:0031419]; methionine synthase activity [GO:0008705]; zinc ion binding [GO:0008270]; homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; methylation [GO:0032259]; tetrahydrofolate interconversion [GO:0035999] cobalamin binding [GO:0031419]; methionine synthase activity [GO:0008705]; zinc ion binding [GO:0008270] GO:0005737; GO:0005829; GO:0008270; GO:0008705; GO:0009086; GO:0031419; GO:0032259; GO:0035999; GO:0050667 +P77338 MSCK_ECOLI Mechanosensitive channel MscK (Potassium efflux system KefA) mscK aefA kefA b0465 JW0454 aefA kefA mscK 127,215 cellular water homeostasis [GO:0009992]; potassium ion transport [GO:0006813]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cellular water homeostasis [GO:0009992]; potassium ion transport [GO:0006813]; transmembrane transport [GO:0055085] GO:0005886; GO:0006813; GO:0009992; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:11985727, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:11985727, ECO:0000269|PubMed:15919996}. +P0A742 MSCL_ECOLI Large-conductance mechanosensitive channel mscL yhdC b3291 JW3252 yhdC mscL 14,957 cellular water homeostasis [GO:0009992]; ion transmembrane transport [GO:0034220]; ion transport [GO:0006811] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; mechanosensitive ion channel activity [GO:0008381]; cellular water homeostasis [GO:0009992]; ion transmembrane transport [GO:0034220]; ion transport [GO:0006811] identical protein binding [GO:0042802]; mechanosensitive ion channel activity [GO:0008381] GO:0005886; GO:0005887; GO:0006811; GO:0008381; GO:0009992; GO:0016020; GO:0016021; GO:0034220; GO:0042802 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00115, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:23416054, ECO:0000269|PubMed:7511799, ECO:0000269|PubMed:8890153, ECO:0000269|PubMed:9632260, ECO:0000305|PubMed:21151884, ECO:0000305|PubMed:23875651}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00115, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:8890153}. +P13669 MNGR_ECOLI Mannosyl-D-glycerate transport/metabolism system repressor MngR (Fatty acyl-responsive regulator) (Protein P30) mngR farR g30 ybgB b0730 JW0719 farR g30 ybgB mngR 28,273 negative regulation of transcription, DNA-templated [GO:0045892]; response to heat [GO:0009408] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892]; response to heat [GO:0009408] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0009408; GO:0045892 +P0ABL3 NAPB_ECOLI Periplasmic nitrate reductase, electron transfer subunit (Diheme cytochrome c NapB) napB yejY b2203 JW5367 yejY napB 16,297 anaerobic respiration [GO:0009061] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; metal ion binding [GO:0046872]; anaerobic respiration [GO:0009061] metal ion binding [GO:0046872] GO:0009061; GO:0042597; GO:0046872 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:10234835, ECO:0000269|PubMed:10548535, ECO:0000269|PubMed:17130127}. +P0AFB1 NLPI_ECOLI Lipoprotein NlpI nlpI yhbM b3163 JW3132 yhbM nlpI 33,621 cell cycle [GO:0007049]; cell division [GO:0051301] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; protein-macromolecule adaptor activity [GO:0030674]; cell cycle [GO:0007049]; cell division [GO:0051301] protein-macromolecule adaptor activity [GO:0030674] GO:0005886; GO:0007049; GO:0030674; GO:0051301 SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. +P0ACU5 FABR_ECOLI HTH-type transcriptional repressor FabR fabR yijC b3963 JW3935 yijC fabR 26,553 fatty acid biosynthetic process [GO:0006633]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of transcription, DNA-templated [GO:0045892] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; fatty acid biosynthetic process [GO:0006633]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0005737; GO:0006633; GO:0045717; GO:0045892 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P09148 GAL7_ECOLI Galactose-1-phosphate uridylyltransferase (Gal-1-P uridylyltransferase) (EC 2.7.7.12) (UDP-glucose--hexose-1-phosphate uridylyltransferase) galT galB b0758 JW0741 galB galT 39,646 galactose catabolic process via UDP-galactose [GO:0033499] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ferrous iron binding [GO:0008198]; galactokinase activity [GO:0004335]; UDP-glucose:hexose-1-phosphate uridylyltransferase activity [GO:0008108]; zinc ion binding [GO:0008270]; galactose catabolic process via UDP-galactose [GO:0033499] ferrous iron binding [GO:0008198]; galactokinase activity [GO:0004335]; UDP-glucose:hexose-1-phosphate uridylyltransferase activity [GO:0008108]; zinc ion binding [GO:0008270] GO:0004335; GO:0005737; GO:0005829; GO:0008108; GO:0008198; GO:0008270; GO:0033499 +P45757 GSPC_ECOLI Putative type II secretion system protein C (T2SS protein C) (Putative general secretion pathway protein C) gspC yheE b3324 JW3286 yheE gspC 30,038 protein secretion by the type II secretion system [GO:0015628] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627]; protein secretion by the type II secretion system [GO:0015628] GO:0005886; GO:0015627; GO:0015628; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +Q46915 GUDX_ECOLI Glucarate dehydratase-related protein (GDH-RP) (GlucDRP) (EC 4.2.1.-) gudX ygcY b2788 JW2759 ygcY gudX 48,850 cellular amino acid catabolic process [GO:0009063]; cellular catabolic process [GO:0044248] lyase activity [GO:0016829]; metal ion binding [GO:0046872]; cellular amino acid catabolic process [GO:0009063]; cellular catabolic process [GO:0044248] lyase activity [GO:0016829]; metal ion binding [GO:0046872] GO:0009063; GO:0016829; GO:0044248; GO:0046872 +P30178 HCXB_ECOLI Hydroxycarboxylate dehydrogenase B (EC 1.1.1.-) (2-oxoglutarate reductase) (Hydroxyphenylpyruvate reductase) (EC 1.1.1.237) (Phenylpyruvate reductase) hcxB ybiC b0801 JW0786 ybiC hcxB 38,897 cytosol [GO:0005829] cytosol [GO:0005829]; hydroxyphenylpyruvate reductase activity [GO:0047995]; R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity [GO:0102742] hydroxyphenylpyruvate reductase activity [GO:0047995]; R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity [GO:0102742] GO:0005829; GO:0047995; GO:0102742 +P31069 KCH_ECOLI Voltage-gated potassium channel Kch kch b1250 JW1242 kch 46,063 potassium ion transport [GO:0006813] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; potassium ion transport [GO:0006813] identical protein binding [GO:0042802] GO:0005886; GO:0006813; GO:0016021; GO:0032991; GO:0042802 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:8824224}; Multi-pass membrane protein {ECO:0000269|PubMed:8824224}. +P11072 LIT_ECOLI Cell death peptidase (Bacteriophage T4 late gene expression-blocking protein) (GpLit) lit b1139 JW1125 lit 33,762 regulation of translational elongation [GO:0006448] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; peptidase activity [GO:0008233]; regulation of translational elongation [GO:0006448] peptidase activity [GO:0008233] GO:0005886; GO:0006448; GO:0008233; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0AEY3 MAZG_ECOLI Nucleoside triphosphate pyrophosphohydrolase (NTP-PPase) (EC 3.6.1.8) mazG b2781 JW2752 mazG 30,412 cellular response to starvation [GO:0009267]; dATP catabolic process [GO:0046061]; dGTP catabolic process [GO:0006203]; dTTP catabolic process [GO:0046076]; dUTP catabolic process [GO:0046081]; TTP catabolic process [GO:0046047]; UTP catabolic process [GO:0046052] ATP binding [GO:0005524]; ATP diphosphatase activity [GO:0047693]; metal ion binding [GO:0046872]; nucleoside-triphosphate diphosphatase activity [GO:0047429]; cellular response to starvation [GO:0009267]; dATP catabolic process [GO:0046061]; dGTP catabolic process [GO:0006203]; dTTP catabolic process [GO:0046076]; dUTP catabolic process [GO:0046081]; TTP catabolic process [GO:0046047]; UTP catabolic process [GO:0046052] ATP binding [GO:0005524]; ATP diphosphatase activity [GO:0047693]; metal ion binding [GO:0046872]; nucleoside-triphosphate diphosphatase activity [GO:0047429] GO:0005524; GO:0006203; GO:0009267; GO:0046047; GO:0046052; GO:0046061; GO:0046076; GO:0046081; GO:0046872; GO:0047429; GO:0047693 +P0AE18 MAP1_ECOLI Methionine aminopeptidase (MAP) (MetAP) (EC 3.4.11.18) (Peptidase M) map b0168 JW0163 map 29,331 protein initiator methionine removal [GO:0070084] cytosol [GO:0005829] cytosol [GO:0005829]; ferrous iron binding [GO:0008198]; metalloaminopeptidase activity [GO:0070006]; protein initiator methionine removal [GO:0070084] ferrous iron binding [GO:0008198]; metalloaminopeptidase activity [GO:0070006] GO:0005829; GO:0008198; GO:0070006; GO:0070084 +P41052 MLTB_ECOLI Membrane-bound lytic murein transglycosylase B (EC 4.2.2.n1) (35 kDa soluble lytic transglycosylase) (Murein hydrolase B) (Slt35) mltB b2701 JW2671 mltB 40,256 cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253] anchored component of cell outer membrane [GO:0036405]; cell outer membrane [GO:0009279]; outer membrane-bounded periplasmic space [GO:0030288] anchored component of cell outer membrane [GO:0036405]; cell outer membrane [GO:0009279]; outer membrane-bounded periplasmic space [GO:0030288]; calcium ion binding [GO:0005509]; lyase activity [GO:0016829]; lytic endotransglycosylase activity [GO:0008932]; lytic transglycosylase activity [GO:0008933]; sodium ion binding [GO:0031402]; cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253] calcium ion binding [GO:0005509]; lyase activity [GO:0016829]; lytic endotransglycosylase activity [GO:0008932]; lytic transglycosylase activity [GO:0008933]; sodium ion binding [GO:0031402] GO:0005509; GO:0008932; GO:0008933; GO:0009253; GO:0009279; GO:0016829; GO:0030288; GO:0031402; GO:0036405; GO:0071555 SUBCELLULAR LOCATION: Cell outer membrane; Lipid-anchor; Periplasmic side. +P77473 PDEB_ECOLI Probable cyclic di-GMP phosphodiesterase PdeB (EC 3.1.4.52) pdeB ylaB b0457 JW5062 ylaB pdeB 58,720 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cyclic-guanylate-specific phosphodiesterase activity [GO:0071111] cyclic-guanylate-specific phosphodiesterase activity [GO:0071111] GO:0005886; GO:0016021; GO:0071111 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P76086 PAAX_ECOLI Transcriptional repressor PaaX paaX ydbY b1399 JW1394 ydbY paaX 35,295 negative regulation of DNA-templated transcription, initiation [GO:2000143]; phenylacetate catabolic process [GO:0010124]; transcription, DNA-templated [GO:0006351] bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding [GO:0000984]; negative regulation of DNA-templated transcription, initiation [GO:2000143]; phenylacetate catabolic process [GO:0010124]; transcription, DNA-templated [GO:0006351] bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding [GO:0000984] GO:0000984; GO:0006351; GO:0010124; GO:2000143 +P27278 NADR_ECOLI Trifunctional NAD biosynthesis/regulator protein NadR [Includes: Transcriptional regulator NadR; Nicotinamide mononucleotide adenylyltransferase (NMN adenylyltransferase) (NMN-AT) (NMNAT) (EC 2.7.7.1) (Nicotinamide ribonucleotide adenylyltransferase) (Nicotinamide-nucleotide adenylyltransferase); Ribosylnicotinamide kinase (RNK) (EC 2.7.1.22) (Nicotinamide riboside kinase) (NRK) (NmR-K)] nadR nadI b4390 JW5800 nadI nadR 47,346 cellular response to metal ion [GO:0071248]; NAD biosynthetic process [GO:0009435]; response to alkaline pH [GO:0010446] catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886] catalytic complex [GO:1902494]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; ribosylnicotinamide kinase activity [GO:0050262]; cellular response to metal ion [GO:0071248]; NAD biosynthetic process [GO:0009435]; response to alkaline pH [GO:0010446] ATP binding [GO:0005524]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; ribosylnicotinamide kinase activity [GO:0050262] GO:0000287; GO:0000309; GO:0000986; GO:0005524; GO:0005737; GO:0005886; GO:0009435; GO:0010446; GO:0042802; GO:0050262; GO:0071248; GO:1902494 SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cytoplasm {ECO:0000250}. +P0ACP5 GNTR_ECOLI HTH-type transcriptional regulator GntR (Gluconate utilization system GNT-I transcriptional repressor) gntR b3438 JW5946 gntR 36,422 cellular response to DNA damage stimulus [GO:0006974]; D-gluconate catabolic process [GO:0046177]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; cellular response to DNA damage stimulus [GO:0006974]; D-gluconate catabolic process [GO:0046177]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0005829; GO:0006355; GO:0006974; GO:0045892; GO:0045893; GO:0046177 +P0A9D2 GSTA_ECOLI Glutathione S-transferase GstA (EC 2.5.1.18) (GST B1-1) gstA gst b1635 JW1627 gst gstA 22,868 glutathione metabolic process [GO:0006749]; response to hydrogen peroxide [GO:0042542] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; glutathione transferase activity [GO:0004364]; glutathione metabolic process [GO:0006749]; response to hydrogen peroxide [GO:0042542] glutathione transferase activity [GO:0004364] GO:0004364; GO:0005737; GO:0006749; GO:0042542 SUBCELLULAR LOCATION: Cytoplasm. +P0A6F3 GLPK_ECOLI Glycerol kinase (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase) (Glycerokinase) (GK) glpK b3926 JW3897 glpK 56,231 cellular response to DNA damage stimulus [GO:0006974]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerol catabolic process [GO:0019563]; glycerol metabolic process [GO:0006071]; phosphorylation [GO:0016310] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; glycerol kinase activity [GO:0004370]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]; cellular response to DNA damage stimulus [GO:0006974]; glycerol catabolic process [GO:0019563]; glycerol metabolic process [GO:0006071]; glycerol-3-phosphate metabolic process [GO:0006072]; phosphorylation [GO:0016310] ATP binding [GO:0005524]; glycerol kinase activity [GO:0004370]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] GO:0004370; GO:0005524; GO:0005829; GO:0006071; GO:0006072; GO:0006974; GO:0008270; GO:0016310; GO:0019563; GO:0042802; GO:0046872 +P33129 HTRE_ECOLI Outer membrane usher protein HtrE (Heat shock protein E) htrE b0139 JW0135 htrE 95,499 cell adhesion [GO:0007155]; pilus assembly [GO:0009297]; pilus organization [GO:0043711] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; fimbrial usher porin activity [GO:0015473]; cell adhesion [GO:0007155]; pilus assembly [GO:0009297]; pilus organization [GO:0043711] fimbrial usher porin activity [GO:0015473] GO:0007155; GO:0009279; GO:0009297; GO:0015473; GO:0016021; GO:0043711 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. +P39343 IDNR_ECOLI HTH-type transcriptional regulator IdnR (L-idonate regulatory protein) idnR yjgS b4264 JW4221 yjgS idnR 37,567 D-gluconate metabolic process [GO:0019521]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; D-gluconate metabolic process [GO:0019521]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355; GO:0019521 +P0AAT6 IOJAP_ECOLI Ribosomal silencing factor RsfS rsfS rsfA slm3 ybeB b0637 JW5090 rsfA slm3 ybeB rsfS 11,582 mature ribosome assembly [GO:0042256]; negative regulation of ribosome biogenesis [GO:0090071]; negative regulation of translation [GO:0017148] cytosol [GO:0005829] cytosol [GO:0005829]; ribosomal large subunit binding [GO:0043023]; mature ribosome assembly [GO:0042256]; negative regulation of ribosome biogenesis [GO:0090071]; negative regulation of translation [GO:0017148] ribosomal large subunit binding [GO:0043023] GO:0005829; GO:0017148; GO:0042256; GO:0043023; GO:0090071 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16980477}. Note=Comigrates with the 50S ribosomal subunit in sucrose gradients, specifically with ribosomal protein L14 (rplN). +P05704 MCP3_ECOLI Methyl-accepting chemotaxis protein III (MCP-III) (Ribose and galactose chemoreceptor protein) trg b1421 JW1417 trg 58,899 chemotaxis [GO:0006935]; signal transduction [GO:0007165] integral component of plasma membrane [GO:0005887]; methyl accepting chemotaxis protein complex [GO:0098561]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; methyl accepting chemotaxis protein complex [GO:0098561]; plasma membrane [GO:0005886]; protein homodimerization activity [GO:0042803]; transmembrane signaling receptor activity [GO:0004888]; chemotaxis [GO:0006935]; signal transduction [GO:0007165] protein homodimerization activity [GO:0042803]; transmembrane signaling receptor activity [GO:0004888] GO:0004888; GO:0005886; GO:0005887; GO:0006935; GO:0007165; GO:0042803; GO:0098561 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:22380631}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:22380631}. Note=Found predominantly at cell poles. +P62617 ISPF_ECOLI 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECDP-synthase) (MECPP-synthase) (MECPS) (EC 4.6.1.12) ispF mecS ygbB b2746 JW2716 mecS ygbB ispF 16,898 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; terpenoid biosynthetic process [GO:0016114]; ubiquinone biosynthetic process [GO:0006744] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity [GO:0008685]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]; isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]; terpenoid biosynthetic process [GO:0016114]; ubiquinone biosynthetic process [GO:0006744] 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity [GO:0008685]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] GO:0006744; GO:0008270; GO:0008685; GO:0016114; GO:0019288; GO:0030145; GO:0042802; GO:0046872 +P0AEW6 INGK_ECOLI Guanosine-inosine kinase (EC 2.7.1.73) gsk b0477 JW0466 gsk 48,449 IMP salvage [GO:0032264] ATP binding [GO:0005524]; inosine kinase activity [GO:0008906]; IMP salvage [GO:0032264] ATP binding [GO:0005524]; inosine kinase activity [GO:0008906] GO:0005524; GO:0008906; GO:0032264 +P39347 INTB_ECOLI Putative protein IntB (Int(P4)) (Putative prophage P4 integrase) intB b4271 JW4227 intB 45,582 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0044826; GO:0046718; GO:0075713 +P75679 INSN1_ECOLI Putative transposase InsN for insertion sequence element IS911A insN1 b0255 JW5024 insN1 15,250 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P13029 KATG_ECOLI Catalase-peroxidase (CP) (EC 1.11.1.21) (Hydroperoxidase I) (HPI) (Peroxidase/catalase) katG b3942 JW3914 katG 80,024 cellular response to hydrogen peroxide [GO:0070301]; hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] cytosol [GO:0005829] cytosol [GO:0005829]; catalase activity [GO:0004096]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; peroxidase activity [GO:0004601]; cellular response to hydrogen peroxide [GO:0070301]; hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] catalase activity [GO:0004096]; heme binding [GO:0020037]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; peroxidase activity [GO:0004601] GO:0004096; GO:0004601; GO:0005829; GO:0006979; GO:0016491; GO:0020037; GO:0042744; GO:0042802; GO:0046872; GO:0070301 +P76008 LDCA_ECOLI Murein tetrapeptide carboxypeptidase (EC 3.4.17.13) (LD-carboxypeptidase A) (Muramoyltetrapeptide carboxypeptidase) ldcA ycgQ b1192 JW1181 ycgQ ldcA 33,567 cell wall organization [GO:0071555]; glycopeptide catabolic process [GO:0009050]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan turnover [GO:0009254]; regulation of cell shape [GO:0008360] cytosol [GO:0005829] cytosol [GO:0005829]; carboxypeptidase activity [GO:0004180]; serine-type peptidase activity [GO:0008236]; cell wall organization [GO:0071555]; glycopeptide catabolic process [GO:0009050]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan turnover [GO:0009254]; regulation of cell shape [GO:0008360] carboxypeptidase activity [GO:0004180]; serine-type peptidase activity [GO:0008236] GO:0004180; GO:0005829; GO:0008236; GO:0008360; GO:0009050; GO:0009252; GO:0009254; GO:0071555 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10428950}. +P24205 LPXM_ECOLI Lipid A biosynthesis myristoyltransferase (EC 2.3.1.243) (Kdo(2)-lauroyl-lipid IV(A) myristoyltransferase) lpxM msbB b1855 JW1844 msbB lpxM 37,410 Kdo2-lipid A biosynthetic process [GO:0036104]; lipopolysaccharide biosynthetic process [GO:0009103] Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of plasma membrane [GO:0005887] Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of plasma membrane [GO:0005887]; myristoyltransferase activity [GO:0019107]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747]; Kdo2-lipid A biosynthetic process [GO:0036104]; lipopolysaccharide biosynthetic process [GO:0009103] myristoyltransferase activity [GO:0019107]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] GO:0005887; GO:0009103; GO:0009276; GO:0016747; GO:0019107; GO:0036104 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01944, ECO:0000269|PubMed:9099672}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01944}. +P76190 MEPH_ECOLI Murein DD-endopeptidase MepH (EC 3.4.-.-) (Murein hydrolase MepH) mepH ydhO b1655 JW5270 ydhO mepH 29,917 capsule polysaccharide biosynthetic process [GO:0045227]; cell wall organization [GO:0071555]; peptidoglycan metabolic process [GO:0000270] cysteine-type peptidase activity [GO:0008234]; endopeptidase activity [GO:0004175]; capsule polysaccharide biosynthetic process [GO:0045227]; cell wall organization [GO:0071555]; peptidoglycan metabolic process [GO:0000270] cysteine-type peptidase activity [GO:0008234]; endopeptidase activity [GO:0004175] GO:0000270; GO:0004175; GO:0008234; GO:0045227; GO:0071555 +P23200 MGLC_ECOLI Galactoside transport system permease protein MglC mglC b2148 JW2135 mglC 35,550 cellular response to DNA damage stimulus [GO:0006974]; galactose transmembrane transport [GO:0015757]; methylgalactoside transport [GO:0015765] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; galactose transmembrane transporter activity [GO:0005354]; methylgalactoside transmembrane transporter activity [GO:0015592]; cellular response to DNA damage stimulus [GO:0006974]; galactose transmembrane transport [GO:0015757]; methylgalactoside transport [GO:0015765] galactose transmembrane transporter activity [GO:0005354]; methylgalactoside transmembrane transporter activity [GO:0015592] GO:0005354; GO:0005886; GO:0006974; GO:0015592; GO:0015757; GO:0015765; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AEU3 HISM_ECOLI Histidine transport system permease protein HisM hisM b2307 JW2304 hisM 26,870 amino acid transport [GO:0006865] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; amino acid transport [GO:0006865] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0006865; GO:0022857; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:15919996}. +P07109 HISP_ECOLI Histidine transport ATP-binding protein HisP hisP b2306 JW2303 hisP 28,653 histidine transport [GO:0015817]; L-histidine import across plasma membrane [GO:1903810]; L-histidine transmembrane transport [GO:0089709] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; high-affinity L-histidine transmembrane transporter activity [GO:0005291]; histidine transport [GO:0015817]; L-histidine import across plasma membrane [GO:1903810]; L-histidine transmembrane transport [GO:0089709] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; high-affinity L-histidine transmembrane transporter activity [GO:0005291] GO:0005291; GO:0005524; GO:0005886; GO:0015817; GO:0042626; GO:0089709; GO:1903810 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. +P60757 HIS1_ECOLI ATP phosphoribosyltransferase (ATP-PRT) (ATP-PRTase) (EC 2.4.2.17) hisG b2019 JW2001 hisG 33,367 histidine biosynthetic process [GO:0000105] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; ATP phosphoribosyltransferase activity [GO:0003879]; magnesium ion binding [GO:0000287]; histidine biosynthetic process [GO:0000105] ATP binding [GO:0005524]; ATP phosphoribosyltransferase activity [GO:0003879]; magnesium ion binding [GO:0000287] GO:0000105; GO:0000287; GO:0003879; GO:0005524; GO:0005829 SUBCELLULAR LOCATION: Cytoplasm. +P23256 MALY_ECOLI Protein MalY [Includes: Cystathionine beta-lyase MalY (CBL) (EC 4.4.1.13) (Beta-cystathionase MalY) (Cysteine lyase MalY) (Cysteine-S-conjugate beta-lyase MalY); Maltose regulon modulator] malY b1622 JW1614 malY 43,642 methionine biosynthetic process [GO:0009086]; negative regulation of DNA-binding transcription factor activity [GO:0043433] cystathionine beta-lyase activity [GO:0004121]; cysteine-S-conjugate beta-lyase activity [GO:0047804]; DNA-binding transcription factor binding [GO:0140297]; L-cysteine desulfhydrase activity [GO:0080146]; pyridoxal phosphate binding [GO:0030170]; methionine biosynthetic process [GO:0009086]; negative regulation of DNA-binding transcription factor activity [GO:0043433] cystathionine beta-lyase activity [GO:0004121]; cysteine-S-conjugate beta-lyase activity [GO:0047804]; DNA-binding transcription factor binding [GO:0140297]; L-cysteine desulfhydrase activity [GO:0080146]; pyridoxal phosphate binding [GO:0030170] GO:0004121; GO:0009086; GO:0030170; GO:0043433; GO:0047804; GO:0080146; GO:0140297 +P10423 IAP_ECOLI Alkaline phosphatase isozyme conversion protein (EC 3.4.11.-) iap b2753 JW2723 iap 37,920 post-translational protein modification [GO:0043687]; proteolysis [GO:0006508] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; aminopeptidase activity [GO:0004177]; metal ion binding [GO:0046872]; metalloexopeptidase activity [GO:0008235]; post-translational protein modification [GO:0043687]; proteolysis [GO:0006508] aminopeptidase activity [GO:0004177]; metal ion binding [GO:0046872]; metalloexopeptidase activity [GO:0008235] GO:0004177; GO:0006508; GO:0008235; GO:0030288; GO:0043687; GO:0046872 +P05793 ILVC_ECOLI Ketol-acid reductoisomerase (NADP(+)) (KARI) (EC 1.1.1.86) (Acetohydroxy-acid isomeroreductase) (AHIR) (Alpha-keto-beta-hydroxylacyl reductoisomerase) (Ketol-acid reductoisomerase type 2) (Ketol-acid reductoisomerase type II) ilvC b3774 JW3747 ilvC 54,069 isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; ketol-acid reductoisomerase activity [GO:0004455]; magnesium ion binding [GO:0000287]; NADP binding [GO:0050661]; isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] identical protein binding [GO:0042802]; ketol-acid reductoisomerase activity [GO:0004455]; magnesium ion binding [GO:0000287]; NADP binding [GO:0050661] GO:0000287; GO:0004455; GO:0005829; GO:0009097; GO:0009099; GO:0032991; GO:0042802; GO:0050661 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:2653423}. +P0ACD4 ISCU_ECOLI Iron-sulfur cluster assembly scaffold protein IscU (Sulfur acceptor protein IscU) iscU nifU yfhN b2529 JW2513 nifU yfhN iscU 13,849 cellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; 2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; ferrous iron binding [GO:0008198]; identical protein binding [GO:0042802]; cellular iron ion homeostasis [GO:0006879]; iron-sulfur cluster assembly [GO:0016226] 2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; ferrous iron binding [GO:0008198]; identical protein binding [GO:0042802] GO:0005737; GO:0005829; GO:0006879; GO:0008198; GO:0016226; GO:0042802; GO:0051537; GO:0051539 +P05827 ILVY_ECOLI HTH-type transcriptional regulator IlvY ilvY b3773 JW3746 ilvY 33,204 branched-chain amino acid biosynthetic process [GO:0009082]; cellular amino acid biosynthetic process [GO:0008652]; regulation of transcription, DNA-templated [GO:0006355] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; branched-chain amino acid biosynthetic process [GO:0009082]; cellular amino acid biosynthetic process [GO:0008652]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0005737; GO:0006355; GO:0008652; GO:0009082 SUBCELLULAR LOCATION: Cytoplasm. +P0CF45 INSC6_ECOLI Transposase InsC for insertion element IS2K insC6 b4272 JW4229 insC6 13,452 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P76102 INSQ_ECOLI Putative transposase InsQ for insertion sequence element IS609 insQ tnpB ydcM b1432 JW5228 tnpB ydcM insQ 43,364 DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; metal ion binding [GO:0046872]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; metal ion binding [GO:0046872] GO:0003677; GO:0006310; GO:0032196; GO:0046872 +Q46938 KDUI_ECOLI 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (EC 5.3.1.17) (5-keto-4-deoxyuronate isomerase) (DKI isomerase) kduI yqeE b2843 JW2811 yqeE kduI 31,076 D-galacturonate catabolic process [GO:0019698]; D-glucuronate catabolic process [GO:0042840]; pectin catabolic process [GO:0045490] cytosol [GO:0005829] cytosol [GO:0005829]; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity [GO:0008697]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]; D-galacturonate catabolic process [GO:0019698]; D-glucuronate catabolic process [GO:0042840]; pectin catabolic process [GO:0045490] 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity [GO:0008697]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] GO:0005829; GO:0008270; GO:0008697; GO:0019698; GO:0042802; GO:0042840; GO:0045490; GO:0046872 +P00804 LSPA_ECOLI Lipoprotein signal peptidase (EC 3.4.23.36) (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II) lspA lsp b0027 JW0025 lsp lspA 18,156 lipoprotein biosynthetic process via signal peptide cleavage [GO:0097304] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175]; lipoprotein biosynthetic process via signal peptide cleavage [GO:0097304] aspartic-type endopeptidase activity [GO:0004190]; endopeptidase activity [GO:0004175] GO:0004175; GO:0004190; GO:0005886; GO:0005887; GO:0097304 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:6368552}; Multi-pass membrane protein {ECO:0000269|PubMed:6368552}. +P0AD83 LPPY_ECOLI pyr operon leader peptide (pyrBI operon attenuator) pyrL b4246 JW4205 pyrL 5,098 pyrimidine nucleobase biosynthetic process [GO:0019856]; pyrimidine nucleotide biosynthetic process [GO:0006221]; transcriptional attenuation [GO:0031555] pyrimidine nucleobase biosynthetic process [GO:0019856]; pyrimidine nucleotide biosynthetic process [GO:0006221]; transcriptional attenuation [GO:0031555] GO:0006221; GO:0019856; GO:0031555 +P75867 LONH_ECOLI Putative Lon protease homolog (EC 3.4.21.-) (ATP-dependent protease La homolog) ycbZ b0955 JW0938 ycbZ 65,819 protein catabolic process [GO:0030163] ATP binding [GO:0005524]; ATP-dependent peptidase activity [GO:0004176]; serine-type endopeptidase activity [GO:0004252]; protein catabolic process [GO:0030163] ATP binding [GO:0005524]; ATP-dependent peptidase activity [GO:0004176]; serine-type endopeptidase activity [GO:0004252] GO:0004176; GO:0004252; GO:0005524; GO:0030163 +P77044 MHPC_ECOLI 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase (EC 3.7.1.14) (2-hydroxy-6-ketonona-2,4-diene-1,9-dioic acid 5,6-hydrolase) (2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioic acid 5,6-hydrolase) (2-hydroxy-6-oxonona-2,4-diene-1,9-dioic acid 5,6-hydrolase) mhpC b0349 JW0340 mhpC 31,937 3-(3-hydroxy)phenylpropionate catabolic process [GO:0019622]; 3-phenylpropionate catabolic process [GO:0019380]; aromatic compound catabolic process [GO:0019439] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity [GO:0052823]; 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity [GO:0018771]; hydrolase activity [GO:0016787]; protein homodimerization activity [GO:0042803]; 3-(3-hydroxy)phenylpropionate catabolic process [GO:0019622]; 3-phenylpropionate catabolic process [GO:0019380]; aromatic compound catabolic process [GO:0019439] 2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity [GO:0052823]; 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity [GO:0018771]; hydrolase activity [GO:0016787]; protein homodimerization activity [GO:0042803] GO:0005737; GO:0016787; GO:0018771; GO:0019380; GO:0019439; GO:0019622; GO:0042803; GO:0052823 +P33940 MQO_ECOLI Malate:quinone oxidoreductase (EC 1.1.5.4) (MQO) (Malate dehydrogenase [quinone]) mqo yojH b2210 JW2198 yojH mqo 60,230 tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; flavin adenine dinucleotide binding [GO:0050660]; malate dehydrogenase (menaquinone) activity [GO:0052589]; malate dehydrogenase (quinone) activity [GO:0008924]; oxidoreductase activity [GO:0016491]; tricarboxylic acid cycle [GO:0006099] flavin adenine dinucleotide binding [GO:0050660]; malate dehydrogenase (menaquinone) activity [GO:0052589]; malate dehydrogenase (quinone) activity [GO:0008924]; oxidoreductase activity [GO:0016491] GO:0005737; GO:0005829; GO:0006099; GO:0008924; GO:0009898; GO:0016491; GO:0050660; GO:0052589 +P0A6U3 MNMG_ECOLI tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG (Glucose-inhibited division protein A) mnmG gidA trmF b3741 JW3719 gidA trmF mnmG 69,521 response to UV [GO:0009411]; tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] cytosol [GO:0005829] cytosol [GO:0005829]; flavin adenine dinucleotide binding [GO:0050660]; response to UV [GO:0009411]; tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] flavin adenine dinucleotide binding [GO:0050660] GO:0002098; GO:0005829; GO:0009411; GO:0030488; GO:0050660 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17062623}. +P77181 PAAY_ECOLI Phenylacetic acid degradation protein PaaY paaY ydbZ b1400 JW1395 ydbZ paaY 21,325 phenylacetate catabolic process [GO:0010124] CoA hydrolase activity [GO:0016289]; transferase activity [GO:0016740]; phenylacetate catabolic process [GO:0010124] CoA hydrolase activity [GO:0016289]; transferase activity [GO:0016740] GO:0010124; GO:0016289; GO:0016740 +P39371 NANM_ECOLI N-acetylneuraminate epimerase (EC 5.1.3.24) (N-acetylneuraminate mutarotase) (Neu5Ac mutarotase) (Sialic acid epimerase) nanM yjhT b4310 JW5777 yjhT nanM 39,572 carbohydrate metabolic process [GO:0005975] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857]; carbohydrate metabolic process [GO:0005975] racemase and epimerase activity, acting on carbohydrates and derivatives [GO:0016857] GO:0005975; GO:0016857; GO:0030288 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:18063573}. +P04425 GSHB_ECOLI Glutathione synthetase (EC 6.3.2.3) (GSH synthetase) (GSH-S) (GSHase) (Glutathione synthase) gshB gsh-II b2947 JW2914 gsh-II gshB 35,561 glutathione biosynthetic process [GO:0006750] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; glutathione synthase activity [GO:0004363]; ligase activity, forming carbon-nitrogen bonds [GO:0016879]; magnesium ion binding [GO:0000287]; glutathione biosynthetic process [GO:0006750] ATP binding [GO:0005524]; glutathione synthase activity [GO:0004363]; ligase activity, forming carbon-nitrogen bonds [GO:0016879]; magnesium ion binding [GO:0000287] GO:0000287; GO:0004363; GO:0005524; GO:0005737; GO:0005829; GO:0006750; GO:0016879 +P77329 HYFG_ECOLI Hydrogenase-4 component G (EC 1.-.-.-) hyfG b2487 JW2472 hyfG 63,383 4 iron, 4 sulfur cluster binding [GO:0051539]; metal cluster binding [GO:0051540]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; nickel cation binding [GO:0016151]; quinone binding [GO:0048038] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal cluster binding [GO:0051540]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; nickel cation binding [GO:0016151]; quinone binding [GO:0048038] GO:0008137; GO:0016151; GO:0048038; GO:0051287; GO:0051539; GO:0051540 +P0A9W6 IBAG_ECOLI Acid stress protein IbaG ibaG yrbA b3190 JW3157 yrbA ibaG 9,452 cytosol [GO:0005829] cytosol [GO:0005829]; 2 iron, 2 sulfur cluster binding [GO:0051537] 2 iron, 2 sulfur cluster binding [GO:0051537] GO:0005829; GO:0051537 +P23917 MAK_ECOLI Fructokinase (EC 2.7.1.4) (D-fructose kinase) (Manno(fructo)kinase) mak yajF b0394 JW0385 yajF mak 32,500 cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; fructokinase activity [GO:0008865]; hexokinase activity [GO:0004396]; mannokinase activity [GO:0019158] ATP binding [GO:0005524]; fructokinase activity [GO:0008865]; hexokinase activity [GO:0004396]; mannokinase activity [GO:0019158] GO:0004396; GO:0005524; GO:0005829; GO:0008865; GO:0019158 +P15006 MCRC_ECOLI Protein McrC mcrC b4345 JW5789 mcrC 40,590 DNA restriction-modification system [GO:0009307] DNA restriction-modification system [GO:0009307] GO:0009307 +C1P608 IBSB_ECOLI Small toxic protein IbsB ibsB b4668 JW2058.2 ibsB 2,064 +C1P615 IBSC_ECOLI Small toxic protein IbsC ibsC b4665 JW2879.1 ibsC 2,209 programmed cell death [GO:0012501] programmed cell death [GO:0012501] GO:0012501 +C1P616 IBSD_ECOLI Small toxic protein IbsD ibsD b4664 JW3023.1 ibsD 2,151 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021] GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +C1P617 IBSE_ECOLI Small toxic protein IbsE ibsE b4666 JW3023.2 ibsE 2,207 programmed cell death [GO:0012501] programmed cell death [GO:0012501] GO:0012501 +P37340 MDTK_ECOLI Multidrug resistance protein MdtK (Multidrug-efflux transporter) mdtK norE norM ydhE b1663 JW1655 norE norM ydhE mdtK 49,447 cellular response to reactive oxygen species [GO:0034614]; dipeptide transmembrane transport [GO:0035442]; drug transmembrane transport [GO:0006855]; protein transport [GO:0015031]; response to antibiotic [GO:0046677]; sodium ion transport [GO:0006814]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transport [GO:0042908] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; dipeptide transmembrane transporter activity [GO:0071916]; solute:cation antiporter activity [GO:0015298]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910]; cellular response to reactive oxygen species [GO:0034614]; dipeptide transmembrane transport [GO:0035442]; drug transmembrane transport [GO:0006855]; protein transport [GO:0015031]; response to antibiotic [GO:0046677]; sodium ion transport [GO:0006814]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]; xenobiotic transport [GO:0042908] dipeptide transmembrane transporter activity [GO:0071916]; solute:cation antiporter activity [GO:0015298]; transmembrane transporter activity [GO:0022857]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0005887; GO:0006814; GO:0006855; GO:0015031; GO:0015298; GO:0016020; GO:0022857; GO:0034614; GO:0035442; GO:0042908; GO:0042910; GO:0046677; GO:0071916; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P0A8N0 MATP_ECOLI Macrodomain Ter protein matP ycbG b0956 JW0939 ycbG matP 17,693 cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome organization [GO:0051276]; chromosome segregation [GO:0007059]; regulation of transcription, DNA-templated [GO:0006355] cytoplasm [GO:0005737]; DNA replication termination region [GO:0097047] cytoplasm [GO:0005737]; DNA replication termination region [GO:0097047]; sequence-specific DNA binding [GO:0043565]; cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome organization [GO:0051276]; chromosome segregation [GO:0007059]; regulation of transcription, DNA-templated [GO:0006355] sequence-specific DNA binding [GO:0043565] GO:0005737; GO:0006355; GO:0007049; GO:0007059; GO:0043565; GO:0051276; GO:0051301; GO:0097047 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01073, ECO:0000269|PubMed:18984159}. Note=Accumulates in the cell as a discrete focus that colocalizes with the Ter macrodomain. +P32053 INTA_ECOLI Prophage integrase IntA (Prophage CP4-57 integrase SlpA) intA intX slpA b2622 JW2602 intX slpA intA 46,652 provirus excision [GO:0032359]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA binding [GO:0003677]; prophage integrase activity [GO:0008979]; provirus excision [GO:0032359]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA binding [GO:0003677]; prophage integrase activity [GO:0008979] GO:0003677; GO:0008979; GO:0032359; GO:0044826; GO:0046718 +Q47718 INSO2_ECOLI Putative transposase InsO for insertion sequence element IS911B insO2 b4285 insO2 22,265 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0032196 +P0ABN1 KDGL_ECOLI Diacylglycerol kinase (DAGK) (EC 2.7.1.107) (Diglyceride kinase) (DGK) dgkA dgk b4042 JW4002 dgk dgkA 13,245 phosphatidic acid biosynthetic process [GO:0006654]; response to UV [GO:0009411] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; diacylglycerol kinase activity [GO:0004143]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phosphatidic acid biosynthetic process [GO:0006654]; response to UV [GO:0009411] ATP binding [GO:0005524]; diacylglycerol kinase activity [GO:0004143]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872] GO:0004143; GO:0005524; GO:0005886; GO:0006654; GO:0009411; GO:0016020; GO:0016021; GO:0042802; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:217867, ECO:0000269|PubMed:2984194, ECO:0000269|PubMed:8071224}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:8071224}. +P0AD59 IVY_ECOLI Inhibitor of vertebrate lysozyme ivy ykfE b0220 JW0210 ykfE ivy 16,872 chaperone-mediated protein folding [GO:0061077]; regulation of catalytic activity [GO:0050790] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; lysozyme inhibitor activity [GO:0060241]; chaperone-mediated protein folding [GO:0061077]; regulation of catalytic activity [GO:0050790] lysozyme inhibitor activity [GO:0060241] GO:0030288; GO:0050790; GO:0060241; GO:0061077 SUBCELLULAR LOCATION: Periplasm. +P0C8K0 KBAZ_ECOLI D-tagatose-1,6-bisphosphate aldolase subunit KbaZ kbaZ agaZ yhaX b3132 JW3101 agaZ yhaX kbaZ 47,192 carbohydrate metabolic process [GO:0005975]; D-tagatose 6-phosphate catabolic process [GO:2001059]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; catalytic activity [GO:0003824]; carbohydrate metabolic process [GO:0005975]; D-tagatose 6-phosphate catabolic process [GO:2001059]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] catalytic activity [GO:0003824] GO:0003824; GO:0005887; GO:0005975; GO:0009401; GO:2001059 +P45395 KDSD_ECOLI Arabinose 5-phosphate isomerase KdsD (API) (L-API) (EC 5.3.1.13) kdsD yrbH b3197 JW3164 yrbH kdsD 35,196 keto-3-deoxy-D-manno-octulosonic acid biosynthetic process [GO:0019294] arabinose-5-phosphate isomerase activity [GO:0019146]; carbohydrate derivative binding [GO:0097367]; metal ion binding [GO:0046872]; keto-3-deoxy-D-manno-octulosonic acid biosynthetic process [GO:0019294] arabinose-5-phosphate isomerase activity [GO:0019146]; carbohydrate derivative binding [GO:0097367]; metal ion binding [GO:0046872] GO:0019146; GO:0019294; GO:0046872; GO:0097367 +P09833 MODC_ECOLI Molybdenum import ATP-binding protein ModC (EC 7.3.2.5) modC chlD narD b0765 JW0748 chlD narD modC 39,102 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ABC-type molybdate transporter activity [GO:0015412]; ATP binding [GO:0005524]; molybdenum ion transmembrane transporter activity [GO:0042888] ABC-type molybdate transporter activity [GO:0015412]; ATP binding [GO:0005524]; molybdenum ion transmembrane transporter activity [GO:0042888] GO:0005524; GO:0005886; GO:0015412; GO:0042888 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. +P0A7B3 NADK_ECOLI NAD kinase (EC 2.7.1.23) (ATP-dependent NAD kinase) nadK yfjB yfjE b2615 JW2596 yfjB yfjE nadK 32,566 NAD metabolic process [GO:0019674]; NADP biosynthetic process [GO:0006741] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NAD+ kinase activity [GO:0003951]; NAD metabolic process [GO:0019674]; NADP biosynthetic process [GO:0006741] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; NAD+ kinase activity [GO:0003951]; NAD binding [GO:0051287] GO:0003951; GO:0005524; GO:0005829; GO:0006741; GO:0019674; GO:0046872; GO:0051287 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00361}. +P63386 MLAF_ECOLI Intermembrane phospholipid transport system ATP-binding protein MlaF (EC 7.6.2.-) mlaF yrbF b3195 JW3162 yrbF mlaF 29,097 plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626] ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0016887; GO:0032991; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:19383799}; Peripheral membrane protein {ECO:0000305|PubMed:19383799}; Cytoplasmic side {ECO:0000305|PubMed:19383799}. +P39370 NANS_ECOLI Probable 9-O-acetyl-N-acetylneuraminic acid deacetylase (Neu5,9Ac2 deacetylase) (EC 3.1.1.-) (Probable 9-O-acetyl-N-acetylneuraminate esterase) (Probable sialyl esterase NanS) nanS yjhS b4309 JW4272 yjhS nanS 36,878 carbohydrate metabolic process [GO:0005975]; carboxylic acid metabolic process [GO:0019752]; N-acetylneuraminate metabolic process [GO:0006054] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; sialate O-acetylesterase activity [GO:0001681]; carbohydrate metabolic process [GO:0005975]; carboxylic acid metabolic process [GO:0019752]; N-acetylneuraminate metabolic process [GO:0006054] sialate O-acetylesterase activity [GO:0001681] GO:0001681; GO:0005975; GO:0006054; GO:0019752; GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000305|PubMed:19749043}. +P77258 NEMA_ECOLI N-ethylmaleimide reductase (NEM reductase) (EC 1.3.1.-) (N-ethylmaleimide reducing enzyme) nemA ydhN b1650 JW1642 ydhN nemA 39,516 2,4,6-trinitrotoluene catabolic process [GO:0046256]; nitroglycerin metabolic process [GO:0018937]; xenobiotic metabolic process [GO:0006805] cytosol [GO:0005829] cytosol [GO:0005829]; chromate reductase activity [GO:0034567]; FMN binding [GO:0010181]; N-ethylmaleimide reductase activity [GO:0008748]; oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [GO:0046857]; 2,4,6-trinitrotoluene catabolic process [GO:0046256]; nitroglycerin metabolic process [GO:0018937]; xenobiotic metabolic process [GO:0006805] chromate reductase activity [GO:0034567]; FMN binding [GO:0010181]; N-ethylmaleimide reductase activity [GO:0008748]; oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [GO:0046857] GO:0005829; GO:0006805; GO:0008748; GO:0010181; GO:0018937; GO:0034567; GO:0046256; GO:0046857 +P04846 NLPA_ECOLI Lipoprotein 28 nlpA b3661 JW3635 nlpA 29,424 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell inner membrane; Lipid-anchor. +P77170 PINQ_ECOLI Serine recombinase PinQ (EC 3.1.22.-) (EC 6.5.1.-) (DNA-invertase PinQ) (Putative DNA-invertase from lambdoid prophage Qin) (Site-specific recombinase PinQ) pinQ ydfL b1545 JW1538 ydfL pinQ 21,852 DNA integration [GO:0015074]; DNA recombination [GO:0006310] DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; ligase activity [GO:0016874]; recombinase activity [GO:0000150]; DNA integration [GO:0015074]; DNA recombination [GO:0006310] DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; ligase activity [GO:0016874]; recombinase activity [GO:0000150] GO:0000150; GO:0003677; GO:0006310; GO:0015074; GO:0016787; GO:0016874 +P0ADI0 PINR_ECOLI Serine recombinase PinR (EC 3.1.22.-) (EC 6.5.1.-) (DNA-invertase PinR) (Putative DNA-invertase from lambdoid prophage Rac) (Site-specific recombinase PinR) pinR ynaD b1374 JW1368 ynaD pinR 21,908 DNA integration [GO:0015074]; DNA recombination [GO:0006310] DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; ligase activity [GO:0016874]; recombinase activity [GO:0000150]; DNA integration [GO:0015074]; DNA recombination [GO:0006310] DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; ligase activity [GO:0016874]; recombinase activity [GO:0000150] GO:0000150; GO:0003677; GO:0006310; GO:0015074; GO:0016787; GO:0016874 +P60782 PLSY_ECOLI Probable glycerol-3-phosphate acyltransferase (G3P acyltransferase) (GPAT) (EC 2.3.1.15) (EC 2.3.1.n5) (Lysophosphatidic acid synthase) (LPA synthase) plsY ygiH b3059 JW3031 ygiH plsY 22,193 phospholipid biosynthetic process [GO:0008654] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; acyl-phosphate glycerol-3-phosphate acyltransferase activity [GO:0043772]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity [GO:0102420]; phospholipid biosynthetic process [GO:0008654] acyl-phosphate glycerol-3-phosphate acyltransferase activity [GO:0043772]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity [GO:0102420] GO:0004366; GO:0005886; GO:0008654; GO:0016021; GO:0043772; GO:0102420 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A763 NDK_ECOLI Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (Nucleoside-2-P kinase) ndk b2518 JW2502 ndk 15,463 CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; purine nucleotide metabolic process [GO:0006163]; pyrimidine nucleotide metabolic process [GO:0006220]; UTP biosynthetic process [GO:0006228] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; purine nucleotide metabolic process [GO:0006163]; pyrimidine nucleotide metabolic process [GO:0006220]; UTP biosynthetic process [GO:0006228] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550] GO:0004550; GO:0005524; GO:0005829; GO:0006163; GO:0006183; GO:0006220; GO:0006228; GO:0006241; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00451, ECO:0000305}. +P0AFK6 POTC_ECOLI Spermidine/putrescine transport system permease protein PotC potC b1124 JW1110 potC 29,111 putrescine transport [GO:0015847]; spermidine transmembrane transport [GO:1903711] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ABC-type polyamine transporter activity [GO:0015417]; putrescine transport [GO:0015847]; spermidine transmembrane transport [GO:1903711] ABC-type polyamine transporter activity [GO:0015417] GO:0005886; GO:0005887; GO:0015417; GO:0015847; GO:0043190; GO:1903711 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:15919996}. +Q47013 ELAD_ECOLI Protease ElaD (EC 3.4.22.-) (Deubiquitinase) (Deubiquitinating enzyme) (DUB) (Deubiquitinating protease) elaD b2269 JW5840 elaD 46,078 protein deubiquitination [GO:0016579] cysteine-type peptidase activity [GO:0008234]; protein deubiquitination [GO:0016579] cysteine-type peptidase activity [GO:0008234] GO:0008234; GO:0016579 +P0ADI4 ENTB_ECOLI Enterobactin synthase component B (EC 6.3.2.14) (Enterobactin biosynthesis bifunctional protein EntB) (Enterochelin synthase B) [Includes: Isochorismatase (EC 3.3.2.1) (2,3-dihydro-2,3-dihydroxybenzoate synthase) (Isochorismate lyase); Aryl carrier protein (ArCP)] entB entG b0595 JW0587 entG entB 32,554 enterobactin biosynthetic process [GO:0009239] cytosol [GO:0005829]; plasma membrane [GO:0005886] cytosol [GO:0005829]; plasma membrane [GO:0005886]; 2,3-dihydroxybenzoate-serine ligase activity [GO:0047527]; identical protein binding [GO:0042802]; isochorismatase activity [GO:0008908]; magnesium ion binding [GO:0000287]; phosphopantetheine binding [GO:0031177]; transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765]; enterobactin biosynthetic process [GO:0009239] 2,3-dihydroxybenzoate-serine ligase activity [GO:0047527]; identical protein binding [GO:0042802]; isochorismatase activity [GO:0008908]; magnesium ion binding [GO:0000287]; phosphopantetheine binding [GO:0031177]; transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765] GO:0000287; GO:0005829; GO:0005886; GO:0008908; GO:0009239; GO:0016765; GO:0031177; GO:0042802; GO:0047527 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10692387}. +P32153 FRVX_ECOLI Putative aminopeptidase FrvX (EC 3.4.11.-) frvX yiiI b3898 JW3869 yiiI frvX 38,733 aminopeptidase activity [GO:0004177]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] aminopeptidase activity [GO:0004177]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] GO:0004177; GO:0008237; GO:0046872 +P76621 GLAH_ECOLI Glutarate 2-hydroxylase (G-2-H) (EC 1.14.11.64) (Carbon starvation induced protein D) glaH csiD gab ygaT b2659 JW5427 csiD gab ygaT glaH 37,360 L-lysine catabolic process [GO:0019477]; response to carbon starvation [GO:0090549] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; ferrous iron binding [GO:0008198]; glutarate dioxygenase activity [GO:0106343]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated [GO:0050498]; L-lysine catabolic process [GO:0019477]; response to carbon starvation [GO:0090549] ferrous iron binding [GO:0008198]; glutarate dioxygenase activity [GO:0106343]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [GO:0016709]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated [GO:0050498] GO:0005506; GO:0008198; GO:0016709; GO:0019477; GO:0032991; GO:0042802; GO:0050498; GO:0090549; GO:0106343 +P0A6V1 GLGC_ECOLI Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) (ADP-glucose pyrophosphorylase) (ADPGlc PPase) (ADP-glucose synthase) glgC b3430 JW3393 glgC 48,698 glycogen biosynthetic process [GO:0005978] glucose-1-phosphate adenylyltransferase complex [GO:0010170] glucose-1-phosphate adenylyltransferase complex [GO:0010170]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; glucose-1-phosphate adenylyltransferase activity [GO:0008878]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; glycogen biosynthetic process [GO:0005978] AMP binding [GO:0016208]; ATP binding [GO:0005524]; glucose-1-phosphate adenylyltransferase activity [GO:0008878]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287] GO:0000287; GO:0005524; GO:0005978; GO:0008878; GO:0010170; GO:0016208; GO:0042802 +P37689 GPMI_ECOLI 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (BPG-independent PGAM) (Phosphoglyceromutase) (iPGM) (EC 5.4.2.12) gpmI pgmI yibO b3612 JW3587 pgmI yibO gpmI 56,194 cellular carbohydrate metabolic process [GO:0044262]; glucose catabolic process [GO:0006007]; glycolytic process [GO:0006096]; response to oxidative stress [GO:0006979] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity [GO:0046537]; manganese ion binding [GO:0030145]; cellular carbohydrate metabolic process [GO:0044262]; glucose catabolic process [GO:0006007]; glycolytic process [GO:0006096]; response to oxidative stress [GO:0006979] 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity [GO:0046537]; manganese ion binding [GO:0030145] GO:0005737; GO:0005829; GO:0006007; GO:0006096; GO:0006979; GO:0030145; GO:0044262; GO:0046537 +P0AEQ6 GLNP_ECOLI Glutamine transport system permease protein GlnP glnP b0810 JW0795 glnP 24,364 amino acid transport [GO:0006865] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; amino acid transport [GO:0006865] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0006865; GO:0022857; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AET5 HDED_ECOLI Protein HdeD hdeD yhiA b3511 JW3479 yhiA hdeD 20,903 response to pH [GO:0009268] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; response to pH [GO:0009268] GO:0005886; GO:0009268; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A9P9 IDNO_ECOLI 5-keto-D-gluconate 5-reductase (EC 1.1.1.69) idnO yjgU b4266 JW4223 yjgU idnO 27,563 L-idonate catabolic process [GO:0046183] gluconate 5-dehydrogenase activity [GO:0008874]; L-idonate catabolic process [GO:0046183] gluconate 5-dehydrogenase activity [GO:0008874] GO:0008874; GO:0046183 +P52061 IXTPA_ECOLI dITP/XTP pyrophosphatase (EC 3.6.1.66) (Deoxyribonucleoside triphosphate pyrophosphohydrolase) (Inosine triphosphate pyrophosphatase) (ITPase) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) rdgB yggV b2954 JW2921 yggV rdgB 21,039 nucleoside triphosphate catabolic process [GO:0009143]; nucleotide metabolic process [GO:0009117]; purine nucleoside triphosphate catabolic process [GO:0009146] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; dITP diphosphatase activity [GO:0035870]; ITP diphosphatase activity [GO:0036220]; magnesium ion binding [GO:0000287]; nucleoside-triphosphatase activity [GO:0017111]; nucleoside-triphosphate diphosphatase activity [GO:0047429]; nucleotide binding [GO:0000166]; protein homodimerization activity [GO:0042803]; XTP diphosphatase activity [GO:0036222]; nucleoside triphosphate catabolic process [GO:0009143]; nucleotide metabolic process [GO:0009117]; purine nucleoside triphosphate catabolic process [GO:0009146] dITP diphosphatase activity [GO:0035870]; ITP diphosphatase activity [GO:0036220]; magnesium ion binding [GO:0000287]; nucleoside-triphosphatase activity [GO:0017111]; nucleoside-triphosphate diphosphatase activity [GO:0047429]; nucleotide binding [GO:0000166]; protein homodimerization activity [GO:0042803]; XTP diphosphatase activity [GO:0036222] GO:0000166; GO:0000287; GO:0005737; GO:0005829; GO:0009117; GO:0009143; GO:0009146; GO:0017111; GO:0035870; GO:0036220; GO:0036222; GO:0042803; GO:0047429 +P32664 NUDC_ECOLI NAD-capped RNA hydrolase NudC (DeNADding enzyme NudC) (EC 3.6.1.-) (NADH pyrophosphatase) (EC 3.6.1.22) nudC yjaD b3996 JW5548 yjaD nudC 29,689 mRNA catabolic process [GO:0006402]; mRNA stabilization [GO:0048255]; NAD-cap decapping [GO:0110155]; NAD catabolic process [GO:0019677]; NADH metabolic process [GO:0006734]; NADP catabolic process [GO:0006742]; ncRNA catabolic process [GO:0034661] cytosol [GO:0005829] cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; NAD+ diphosphatase activity [GO:0000210]; NADH pyrophosphatase activity [GO:0035529]; RNA NAD-cap (NMN-forming) hydrolase activity [GO:0110153]; zinc ion binding [GO:0008270]; mRNA catabolic process [GO:0006402]; mRNA stabilization [GO:0048255]; NAD catabolic process [GO:0019677]; NAD-cap decapping [GO:0110155]; NADH metabolic process [GO:0006734]; NADP catabolic process [GO:0006742]; ncRNA catabolic process [GO:0034661] magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; NAD+ diphosphatase activity [GO:0000210]; NADH pyrophosphatase activity [GO:0035529]; RNA NAD-cap (NMN-forming) hydrolase activity [GO:0110153]; zinc ion binding [GO:0008270] GO:0000210; GO:0000287; GO:0005829; GO:0006402; GO:0006734; GO:0006742; GO:0008270; GO:0019677; GO:0030145; GO:0034661; GO:0035529; GO:0048255; GO:0110153; GO:0110155 +P77324 PAOB_ECOLI Aldehyde oxidoreductase FAD-binding subunit PaoB (EC 1.2.99.6) paoB yagS b0285 JW0279 yagS paoB 33,858 periplasmic space [GO:0042597] periplasmic space [GO:0042597]; 4 iron, 4 sulfur cluster binding [GO:0051539]; carboxylate reductase activity [GO:0047770]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on the aldehyde or oxo group of donors [GO:0016903] 4 iron, 4 sulfur cluster binding [GO:0051539]; carboxylate reductase activity [GO:0047770]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on the aldehyde or oxo group of donors [GO:0016903] GO:0016903; GO:0042597; GO:0046872; GO:0047770; GO:0050660; GO:0051539; GO:0071949 SUBCELLULAR LOCATION: Periplasm {ECO:0000305|PubMed:19368556}. +P0A6X7 IHFA_ECOLI Integration host factor subunit alpha (IHF-alpha) ihfA hid himA b1712 JW1702 hid himA ihfA 11,354 conjugation [GO:0000746]; DNA recombination [GO:0006310]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829]; nucleoid [GO:0009295]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; nucleoid [GO:0009295]; protein-DNA complex [GO:0032993]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; conjugation [GO:0000746]; DNA recombination [GO:0006310]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000746; GO:0000976; GO:0001216; GO:0003677; GO:0005829; GO:0006310; GO:0006351; GO:0006417; GO:0009295; GO:0032993 SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000269|PubMed:21903814}. Note=Scattered throughout the nucleoid (PubMed:21903814). {ECO:0000269|PubMed:21903814}. +P02942 MCP1_ECOLI Methyl-accepting chemotaxis protein I (MCP-I) (Serine chemoreceptor protein) tsr cheD b4355 JW4318 cheD tsr 59,443 cell motility [GO:0048870]; cellular response to amino acid stimulus [GO:0071230]; chemotaxis [GO:0006935]; detection of chemical stimulus [GO:0009593]; receptor clustering [GO:0043113]; regulation of bacterial-type flagellum-dependent cell motility [GO:1902021]; regulation of chemotaxis [GO:0050920]; regulation of protein histidine kinase activity [GO:0032110]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165] integral component of plasma membrane [GO:0005887]; methyl accepting chemotaxis protein complex [GO:0098561] integral component of plasma membrane [GO:0005887]; methyl accepting chemotaxis protein complex [GO:0098561]; identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888]; cell motility [GO:0048870]; cellular response to amino acid stimulus [GO:0071230]; chemotaxis [GO:0006935]; detection of chemical stimulus [GO:0009593]; receptor clustering [GO:0043113]; regulation of bacterial-type flagellum-dependent cell motility [GO:1902021]; regulation of chemotaxis [GO:0050920]; regulation of protein histidine kinase activity [GO:0032110]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165] identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888] GO:0004888; GO:0005887; GO:0006935; GO:0007165; GO:0007172; GO:0009593; GO:0032110; GO:0042802; GO:0043113; GO:0048870; GO:0050920; GO:0071230; GO:0098561; GO:1902021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:22380631}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:22380631}. Note=Found predominantly at cell poles. +P0A6B7 ISCS_ECOLI Cysteine desulfurase IscS (EC 2.8.1.7) (NifS protein homolog) (ThiI transpersulfidase) (TusA transpersulfidase) iscS nuvC yfhO yzzO b2530 JW2514 nuvC yfhO yzzO iscS 45,090 [2Fe-2S] cluster assembly [GO:0044571]; iron-sulfur cluster assembly [GO:0016226]; oxazole or thiazole biosynthetic process [GO:0018131]; tRNA pseudouridine synthesis [GO:0031119] cytosol [GO:0005829] cytosol [GO:0005829]; 2 iron, 2 sulfur cluster binding [GO:0051537]; cysteine desulfurase activity [GO:0031071]; metal ion binding [GO:0046872]; pyridoxal phosphate binding [GO:0030170]; selenocysteine lyase activity [GO:0009000]; sulfur carrier activity [GO:0097163]; [2Fe-2S] cluster assembly [GO:0044571]; iron-sulfur cluster assembly [GO:0016226]; oxazole or thiazole biosynthetic process [GO:0018131]; tRNA pseudouridine synthesis [GO:0031119] 2 iron, 2 sulfur cluster binding [GO:0051537]; cysteine desulfurase activity [GO:0031071]; metal ion binding [GO:0046872]; pyridoxal phosphate binding [GO:0030170]; selenocysteine lyase activity [GO:0009000]; sulfur carrier activity [GO:0097163] GO:0005829; GO:0009000; GO:0016226; GO:0018131; GO:0030170; GO:0031071; GO:0031119; GO:0044571; GO:0046872; GO:0051537; GO:0097163 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00331, ECO:0000305}. +P0A715 KDSA_ECOLI 2-dehydro-3-deoxyphosphooctonate aldolase (EC 2.5.1.55) (3-deoxy-D-manno-octulosonic acid 8-phosphate synthase) (KDO-8-phosphate synthase) (KDO 8-P synthase) (KDOPS) (Phospho-2-dehydro-3-deoxyoctonate aldolase) kdsA b1215 JW1206 kdsA 30,833 keto-3-deoxy-D-manno-octulosonic acid biosynthetic process [GO:0019294] cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; 3-deoxy-8-phosphooctulonate synthase activity [GO:0008676]; identical protein binding [GO:0042802]; keto-3-deoxy-D-manno-octulosonic acid biosynthetic process [GO:0019294] 3-deoxy-8-phosphooctulonate synthase activity [GO:0008676]; identical protein binding [GO:0042802] GO:0005829; GO:0008676; GO:0019294; GO:0032991; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm. +P0A712 KDGT_ECOLI 2-keto-3-deoxygluconate permease (KDG permease) kdgT b3909 JW5560 kdgT 33,669 gluconate transmembrane transport [GO:0035429] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; 2-keto-3-deoxygluconate:proton symporter activity [GO:0015649]; gluconate transmembrane transport [GO:0035429] 2-keto-3-deoxygluconate:proton symporter activity [GO:0015649] GO:0005886; GO:0015649; GO:0016021; GO:0035429 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P21645 LPXD_ECOLI UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase (UDP-3-O-(3-OHC14)-GlcN N-acyltransferase) (EC 2.3.1.191) (Protein FirA) (Rifampicin resistance protein) (UDP-3-O-(3-hydroxytetradecanoyl)glucosamine N-acyltransferase) lpxD firA omsA b0179 JW0174 firA omsA lpxD 36,038 lipid A biosynthetic process [GO:0009245]; response to antibiotic [GO:0046677] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; N-acyltransferase activity [GO:0016410]; UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity [GO:0103118]; lipid A biosynthetic process [GO:0009245]; response to antibiotic [GO:0046677] identical protein binding [GO:0042802]; N-acyltransferase activity [GO:0016410]; UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity [GO:0103118] GO:0005737; GO:0005829; GO:0009245; GO:0016410; GO:0042802; GO:0046677; GO:0103118 +P0AF98 LPTF_ECOLI Lipopolysaccharide export system permease protein LptF lptF yjgP b4261 JW4218 yjgP lptF 40,358 lipopolysaccharide transport [GO:0015920]; transmembrane transport [GO:0055085] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transporter complex [GO:1990351] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transporter complex [GO:1990351]; lipopolysaccharide transport [GO:0015920]; transmembrane transport [GO:0055085] GO:0005886; GO:0015920; GO:0016021; GO:0043190; GO:0055085; GO:1990351 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AD72 LPF_ECOLI phe operon leader peptide (phe operon attenuator peptide) pheL pheAE b2598 JW2579 pheAE pheL 1,924 +P03030 LYSR_ECOLI Transcriptional activator protein LysR lysR b2839 JW2807 lysR 34,365 lysine biosynthetic process via diaminopimelate [GO:0009089]; positive regulation of gene expression [GO:0010628] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; lysine biosynthetic process via diaminopimelate [GO:0009089]; positive regulation of gene expression [GO:0010628] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0005737; GO:0009089; GO:0010628; GO:0043565 SUBCELLULAR LOCATION: Cytoplasm. +P0C0T5 MEPA_ECOLI Penicillin-insensitive murein endopeptidase (EC 3.4.24.-) (D-alanyl-D-alanine-endopeptidase) (DD-endopeptidase) mepA b2328 JW2325 mepA 30,137 peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan metabolic process [GO:0000270]; response to drug [GO:0042493] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan metabolic process [GO:0000270]; response to drug [GO:0042493] endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252] GO:0000270; GO:0004175; GO:0004222; GO:0004252; GO:0008233; GO:0009252; GO:0030288; GO:0042493; GO:0046872 SUBCELLULAR LOCATION: Periplasm {ECO:0000305|PubMed:15292190}. +P06721 METC_ECOLI Cystathionine beta-lyase MetC (CBL) (CL) (EC 4.4.1.13) (Beta-cystathionase MetC) (Cysteine desulfhydrase MetC) (CD) (EC 4.4.1.28) (Cysteine lyase MetC) (Cysteine-S-conjugate beta-lyase MetC) metC b3008 JW2975 metC 43,212 L-cysteine catabolic process to pyruvate [GO:0019450]; methionine biosynthetic process [GO:0009086]; protein homotetramerization [GO:0051289]; transsulfuration [GO:0019346] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; alanine racemase activity [GO:0008784]; cystathionine beta-lyase activity [GO:0004121]; cysteine-S-conjugate beta-lyase activity [GO:0047804]; identical protein binding [GO:0042802]; L-cysteine desulfhydrase activity [GO:0080146]; pyridoxal phosphate binding [GO:0030170]; L-cysteine catabolic process to pyruvate [GO:0019450]; methionine biosynthetic process [GO:0009086]; protein homotetramerization [GO:0051289]; transsulfuration [GO:0019346] alanine racemase activity [GO:0008784]; cystathionine beta-lyase activity [GO:0004121]; cysteine-S-conjugate beta-lyase activity [GO:0047804]; identical protein binding [GO:0042802]; L-cysteine desulfhydrase activity [GO:0080146]; pyridoxal phosphate binding [GO:0030170] GO:0004121; GO:0005737; GO:0008784; GO:0009086; GO:0019346; GO:0019450; GO:0030170; GO:0042802; GO:0047804; GO:0051289; GO:0080146 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P76270 MSRC_ECOLI Free methionine-R-sulfoxide reductase (fRMsr) (EC 1.8.4.14) msrC yebR b1832 JW1821 yebR msrC 18,122 cytosol [GO:0005829] cytosol [GO:0005829]; L-methionine-(R)-S-oxide reductase activity [GO:0033745]; methionine-R-sulfoxide reductase activity [GO:0070191] L-methionine-(R)-S-oxide reductase activity [GO:0033745]; methionine-R-sulfoxide reductase activity [GO:0070191] GO:0005829; GO:0033745; GO:0070191 +P32696 PSPG_ECOLI Phage shock protein G pspG yjbO b4050 JW5716 yjbO pspG 9,023 phage shock [GO:0009271] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; phage shock [GO:0009271] GO:0005886; GO:0009271; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:19555453}; Multi-pass membrane protein {ECO:0000269|PubMed:19555453}. Note=Localizes at both cell poles and along the length of the cell. +P0AFF6 NUSA_ECOLI Transcription termination/antitermination protein NusA (N utilization substance protein A) (Transcription termination/antitermination L factor) nusA b3169 JW3138 nusA 54,871 protein complex oligomerization [GO:0051259]; ribosome biogenesis [GO:0042254]; transcription antitermination [GO:0031564]; transcription termination from bacterial-type RNA polymerase promoter [GO:0001125] cytosol [GO:0005829] cytosol [GO:0005829]; bacterial-type RNA polymerase core enzyme binding [GO:0001000]; DNA-binding transcription factor activity [GO:0003700]; nucleotide binding [GO:0000166]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; protein complex oligomerization [GO:0051259]; ribosome biogenesis [GO:0042254]; transcription antitermination [GO:0031564]; transcription termination from bacterial-type RNA polymerase promoter [GO:0001125] bacterial-type RNA polymerase core enzyme binding [GO:0001000]; DNA-binding transcription factor activity [GO:0003700]; nucleotide binding [GO:0000166]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723] GO:0000166; GO:0001000; GO:0001125; GO:0003700; GO:0003723; GO:0005829; GO:0019904; GO:0031564; GO:0042254; GO:0051259 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00945, ECO:0000269|PubMed:17272300}. Note=Colocalizes with nucleoids. +P31663 PANC_ECOLI Pantothenate synthetase (PS) (EC 6.3.2.1) (Pantoate--beta-alanine ligase) (Pantoate-activating enzyme) panC b0133 JW0129 panC 31,598 pantothenate biosynthetic process [GO:0015940] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; pantoate-beta-alanine ligase activity [GO:0004592]; pantothenate biosynthetic process [GO:0015940] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; pantoate-beta-alanine ligase activity [GO:0004592] GO:0004592; GO:0005524; GO:0005829; GO:0015940; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +Q46790 PBL_ECOLI Putative peptidoglycan-binding-like protein pbl b2854 pbl 18,277 periplasmic space [GO:0042597] periplasmic space [GO:0042597] GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P0AEY5 MDAB_ECOLI NADPH:quinone oxidoreductase MdaB (EC 1.6.5.10) (Modulator of drug activity B) mdaB mda66 b3028 JW2996 mda66 mdaB 21,891 cytosol [GO:0005829] cytosol [GO:0005829]; flavin adenine dinucleotide binding [GO:0050660]; NADPH dehydrogenase (quinone) activity [GO:0008753] flavin adenine dinucleotide binding [GO:0050660]; NADPH dehydrogenase (quinone) activity [GO:0008753] GO:0005829; GO:0008753; GO:0050660 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8611590}. +P0C066 MLTC_ECOLI Membrane-bound lytic murein transglycosylase C (EC 4.2.2.n1) (Murein lyase C) mltC yggZ b2963 JW5481 yggZ mltC 40,113 cellular response to oxidative stress [GO:0034599]; cell wall macromolecule catabolic process [GO:0016998]; cell wall organization [GO:0071555]; peptidoglycan catabolic process [GO:0009253] anchored component of membrane [GO:0031225]; cell outer membrane [GO:0009279]; outer membrane-bounded periplasmic space [GO:0030288] anchored component of membrane [GO:0031225]; cell outer membrane [GO:0009279]; outer membrane-bounded periplasmic space [GO:0030288]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; lyase activity [GO:0016829]; lytic endotransglycosylase activity [GO:0008932]; lytic transglycosylase activity [GO:0008933]; cell wall macromolecule catabolic process [GO:0016998]; cell wall organization [GO:0071555]; cellular response to oxidative stress [GO:0034599]; peptidoglycan catabolic process [GO:0009253] hydrolase activity, acting on glycosyl bonds [GO:0016798]; lyase activity [GO:0016829]; lytic endotransglycosylase activity [GO:0008932]; lytic transglycosylase activity [GO:0008933] GO:0008932; GO:0008933; GO:0009253; GO:0009279; GO:0016798; GO:0016829; GO:0016998; GO:0030288; GO:0031225; GO:0034599; GO:0071555 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P37329 MODA_ECOLI Molybdate-binding protein ModA (Molybdate/tungstate-binding protein ModA) modA b0763 JW0746 modA 27,364 molybdate ion transport [GO:0015689]; response to chromate [GO:0046687] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; ABC-type molybdate transporter activity [GO:0015412]; molybdate ion binding [GO:0030973]; molybdenum ion binding [GO:0030151]; tungstate binding [GO:1901359]; molybdate ion transport [GO:0015689]; response to chromate [GO:0046687] ABC-type molybdate transporter activity [GO:0015412]; molybdate ion binding [GO:0030973]; molybdenum ion binding [GO:0030151]; tungstate binding [GO:1901359] GO:0015412; GO:0015689; GO:0030151; GO:0030288; GO:0030973; GO:0046687; GO:1901359 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:8409926, ECO:0000269|PubMed:8576221, ECO:0000269|PubMed:9545596}. +P0AFA2 NARX_ECOLI Nitrate/nitrite sensor protein NarX (EC 2.7.13.3) narX narR b1222 JW1213 narR narX 67,084 cellular response to DNA damage stimulus [GO:0006974]; cellular response to nitrate [GO:0071249]; cellular response to nitrite [GO:0071250]; nitrate assimilation [GO:0042128]; protein autophosphorylation [GO:0046777]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155]; protein dimerization activity [GO:0046983]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to nitrate [GO:0071249]; cellular response to nitrite [GO:0071250]; nitrate assimilation [GO:0042128]; protein autophosphorylation [GO:0046777]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] ATP binding [GO:0005524]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155]; protein dimerization activity [GO:0046983] GO:0000155; GO:0004721; GO:0005524; GO:0005886; GO:0005887; GO:0006470; GO:0006974; GO:0007165; GO:0030288; GO:0042128; GO:0046777; GO:0046983; GO:0071249; GO:0071250 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P75959 NAGK_ECOLI N-acetyl-D-glucosamine kinase (EC 2.7.1.59) (GlcNAc kinase) nagK ycfX b1119 JW1105 ycfX nagK 33,043 N-acetylglucosamine metabolic process [GO:0006044]; peptidoglycan turnover [GO:0009254] ATP binding [GO:0005524]; N-acetylglucosamine kinase activity [GO:0045127]; zinc ion binding [GO:0008270]; N-acetylglucosamine metabolic process [GO:0006044]; peptidoglycan turnover [GO:0009254] ATP binding [GO:0005524]; N-acetylglucosamine kinase activity [GO:0045127]; zinc ion binding [GO:0008270] GO:0005524; GO:0006044; GO:0008270; GO:0009254; GO:0045127 +Q47005 NAC_ECOLI Nitrogen assimilation regulatory protein nac (Nitrogen assimilation control protein) nac b1988 JW1967 nac 32,835 negative regulation of transcription, DNA-templated [GO:0045892]; nitrate assimilation [GO:0042128]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of DNA-templated transcription, initiation [GO:2000142] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892]; nitrate assimilation [GO:0042128]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of DNA-templated transcription, initiation [GO:2000142] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0042128; GO:0045892; GO:0045893; GO:2000142 +P0AC26 NIRC_ECOLI Nitrite transporter NirC nirC b3367 JW3330 nirC 28,563 formate transport [GO:0015724]; nitrate assimilation [GO:0042128] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; formate transmembrane transporter activity [GO:0015499]; formate transport [GO:0015724]; nitrate assimilation [GO:0042128] formate transmembrane transporter activity [GO:0015499] GO:0005886; GO:0005887; GO:0015499; GO:0015724; GO:0042128 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0A9G2 NHAR_ECOLI Transcriptional activator protein NhaR (Na(+)/H(+) antiporter regulatory protein) nhaR antO b0020 JW0019 antO nhaR 34,284 positive regulation of DNA-templated transcription, initiation [GO:2000144]; regulation of DNA-templated transcription, initiation [GO:2000142] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; regulation of DNA-templated transcription, initiation [GO:2000142] DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700] GO:0001216; GO:0003677; GO:0003700; GO:0005737; GO:2000142; GO:2000144 SUBCELLULAR LOCATION: Cytoplasm. +P52006 NUDI_ECOLI Nucleoside triphosphatase NudI (EC 3.6.1.9) (Nucleotide diphosphatase NudI) (Pyrimidine deoxynucleoside triphosphate diphosphatase) (dCTP diphosphatase) (EC 3.6.1.12) (dTTP diphosphatase) (EC 3.6.1.-) (dUTP diphosphatase) (EC 3.6.1.23) nudI yfaO b2251 JW2245 yfaO nudI 16,371 dCTP diphosphatase activity [GO:0047840]; dTTP diphosphatase activity [GO:0036218]; dUTP diphosphatase activity [GO:0004170]; magnesium ion binding [GO:0000287]; NADH pyrophosphatase activity [GO:0035529] dCTP diphosphatase activity [GO:0047840]; dTTP diphosphatase activity [GO:0036218]; dUTP diphosphatase activity [GO:0004170]; magnesium ion binding [GO:0000287]; NADH pyrophosphatase activity [GO:0035529] GO:0000287; GO:0004170; GO:0035529; GO:0036218; GO:0047840 +P0AFF0 NUON_ECOLI NADH-quinone oxidoreductase subunit N (EC 7.1.1.-) (NADH dehydrogenase I subunit N) (NDH-1 subunit N) (NUO14) nuoN b2276 JW2271 nuoN 52,044 aerobic respiration [GO:0009060]; ATP synthesis coupled electron transport [GO:0042773]; electron transport coupled proton transport [GO:0015990] integral component of plasma membrane [GO:0005887]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272] integral component of plasma membrane [GO:0005887]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038]; aerobic respiration [GO:0009060]; ATP synthesis coupled electron transport [GO:0042773]; electron transport coupled proton transport [GO:0015990] NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] GO:0005886; GO:0005887; GO:0008137; GO:0009060; GO:0015990; GO:0030964; GO:0042773; GO:0045272; GO:0048038 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76079 PAAC_ECOLI 1,2-phenylacetyl-CoA epoxidase, subunit C (1,2-phenylacetyl-CoA epoxidase, structural subunit beta) (1,2-phenylacetyl-CoA monooxygenase, subunit C) paaC ydbP b1390 JW1385 ydbP paaC 27,877 phenylacetate catabolic process [GO:0010124] cytosol [GO:0005829] cytosol [GO:0005829]; phenylacetate catabolic process [GO:0010124] GO:0005829; GO:0010124 +P77467 PAAG_ECOLI 1,2-epoxyphenylacetyl-CoA isomerase (EC 5.3.3.18) paaG ydbT b1394 JW1389 ydbT paaG 28,405 fatty acid beta-oxidation [GO:0006635]; phenylacetate catabolic process [GO:0010124] enoyl-CoA hydratase activity [GO:0004300]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]; fatty acid beta-oxidation [GO:0006635]; phenylacetate catabolic process [GO:0010124] enoyl-CoA hydratase activity [GO:0004300]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853] GO:0004300; GO:0006635; GO:0010124; GO:0016853; GO:0042802 +P0A790 PAND_ECOLI Aspartate 1-decarboxylase (EC 4.1.1.11) (Aspartate alpha-decarboxylase) [Cleaved into: Aspartate 1-decarboxylase beta chain; Aspartate 1-decarboxylase alpha chain] panD b0131 JW0127 panD 13,834 alanine biosynthetic process [GO:0006523]; pantothenate biosynthetic process [GO:0015940]; protein autoprocessing [GO:0016540] cytosol [GO:0005829] cytosol [GO:0005829]; aspartate 1-decarboxylase activity [GO:0004068]; alanine biosynthetic process [GO:0006523]; pantothenate biosynthetic process [GO:0015940]; protein autoprocessing [GO:0016540] aspartate 1-decarboxylase activity [GO:0004068] GO:0004068; GO:0005829; GO:0006523; GO:0015940; GO:0016540 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:6767707}. +P16684 PHNF_ECOLI Probable transcriptional regulator PhnF phnF b4102 JW4063 phnF 27,621 organic phosphonate transport [GO:0015716] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; organic phosphonate transport [GO:0015716] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0015716 +P16682 PHND_ECOLI Phosphonates-binding periplasmic protein phnD psiD b4105 JW4066 psiD phnD 37,371 organic phosphonate transport [GO:0015716]; transmembrane transport [GO:0055085] ATP-binding cassette (ABC) transporter complex [GO:0043190]; periplasmic space [GO:0042597] ATP-binding cassette (ABC) transporter complex [GO:0043190]; periplasmic space [GO:0042597]; organic phosphonate transport [GO:0015716]; transmembrane transport [GO:0055085] GO:0015716; GO:0042597; GO:0043190; GO:0055085 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P77528 PEAD_ECOLI Putative protein PeaD peaD ybcD b4508 ybcD peaD 8,493 DNA replication initiation [GO:0006270] DNA replication initiation [GO:0006270] GO:0006270 +P23873 HIPB_ECOLI Antitoxin HipB hipB b1508 JW1501 hipB 10,016 negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351] protein-DNA complex [GO:0032993] protein-DNA complex [GO:0032993]; bacterial-type RNA polymerase core promoter sequence-specific DNA binding [GO:0000985]; DNA-binding transcription repressor activity [GO:0001217]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351] bacterial-type RNA polymerase core promoter sequence-specific DNA binding [GO:0000985]; DNA-binding transcription repressor activity [GO:0001217]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0000985; GO:0001217; GO:0006351; GO:0032993; GO:0043565; GO:0045892 +P37305 HOKA_ECOLI Protein HokA hokA yiaZ b4455 JW3526 yiaZ hokA 5,998 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:P0ACG4, ECO:0000305}; Single-pass membrane protein {ECO:0000250|UniProtKB:P0ACG4}. +P0A707 IF3_ECOLI Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S] infC fit srjA b1718 JW5829 fit srjA infC 20,564 response to cold [GO:0009409]; ribosome disassembly [GO:0032790] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743]; response to cold [GO:0009409]; ribosome disassembly [GO:0032790] ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743] GO:0003743; GO:0005829; GO:0009409; GO:0016020; GO:0032790; GO:0043022 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:330233}. +P22939 ISPA_ECOLI Farnesyl diphosphate synthase (FPP synthase) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Geranyltranstransferase) ispA b0421 JW0411 ispA 32,160 farnesyl diphosphate biosynthetic process [GO:0045337]; geranyl diphosphate biosynthetic process [GO:0033384] cytosol [GO:0005829] cytosol [GO:0005829]; dimethylallyltranstransferase activity [GO:0004161]; geranyltranstransferase activity [GO:0004337]; metal ion binding [GO:0046872]; prenyltransferase activity [GO:0004659]; farnesyl diphosphate biosynthetic process [GO:0045337]; geranyl diphosphate biosynthetic process [GO:0033384] dimethylallyltranstransferase activity [GO:0004161]; geranyltranstransferase activity [GO:0004337]; metal ion binding [GO:0046872]; prenyltransferase activity [GO:0004659] GO:0004161; GO:0004337; GO:0004659; GO:0005829; GO:0033384; GO:0045337; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm. +P03819 KEFC_ECOLI Glutathione-regulated potassium-efflux system protein KefC (K(+)/H(+) antiporter) kefC trkC b0047 JW0046 trkC kefC 67,796 potassium ion transport [GO:0006813]; regulation of pH [GO:0006885]; response to methylglyoxal [GO:0051595]; response to toxic substance [GO:0009636] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; glutathione-regulated potassium exporter activity [GO:0015503]; nucleotide binding [GO:0000166]; solute:proton antiporter activity [GO:0015299]; toxic substance binding [GO:0015643]; potassium ion transport [GO:0006813]; regulation of pH [GO:0006885]; response to methylglyoxal [GO:0051595]; response to toxic substance [GO:0009636] enzyme binding [GO:0019899]; glutathione-regulated potassium exporter activity [GO:0015503]; nucleotide binding [GO:0000166]; solute:proton antiporter activity [GO:0015299]; toxic substance binding [GO:0015643] GO:0000166; GO:0005886; GO:0005887; GO:0006813; GO:0006885; GO:0009636; GO:0015299; GO:0015503; GO:0015643; GO:0016020; GO:0019899; GO:0051595 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01413, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2046548}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01413, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2046548}. +P10151 LEUO_ECOLI HTH-type transcriptional regulator LeuO leuO b0076 JW0075 leuO 35,695 regulation of transcription, DNA-templated [GO:0006355] protein-DNA complex [GO:0032993] protein-DNA complex [GO:0032993]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0006355; GO:0032993; GO:0043565 +Q6BF87 LDRB_ECOLI Small toxic polypeptide LdrB ldrB b4421 JW5958 ldrB 3,972 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:P0DPD0}; Single-pass membrane protein {ECO:0000255}. +P61320 LOLB_ECOLI Outer-membrane lipoprotein LolB lolB hemM ychC b1209 JW1200 hemM ychC lolB 23,551 lipoprotein localization to outer membrane [GO:0044874]; lipoprotein metabolic process [GO:0042157]; protein transport [GO:0015031] anchored component of periplasmic side of cell outer membrane [GO:0036406]; outer membrane-bounded periplasmic space [GO:0030288] anchored component of periplasmic side of cell outer membrane [GO:0036406]; outer membrane-bounded periplasmic space [GO:0030288]; lipoprotein localization to outer membrane [GO:0044874]; lipoprotein metabolic process [GO:0042157]; protein transport [GO:0015031] GO:0015031; GO:0030288; GO:0036406; GO:0042157; GO:0044874 SUBCELLULAR LOCATION: Cell outer membrane; Lipid-anchor. +P69367 MDTH_ECOLI Multidrug resistance protein MdtH mdtH yceL b1065 JW1052 yceL mdtH 44,363 response to antibiotic [GO:0046677] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; response to antibiotic [GO:0046677] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857; GO:0046677 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AAG5 MDLB_ECOLI Multidrug resistance-like ATP-binding protein MdlB (EC 7.6.2.2) mdlB mdl b0449 JW5061 mdl mdlB 65,222 transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ABC-type xenobiotic transporter activity [GO:0008559]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; transmembrane transport [GO:0055085] ABC-type xenobiotic transporter activity [GO:0008559]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0008559; GO:0016021; GO:0042626; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P08373 MURB_ECOLI UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.3.1.98) (UDP-N-acetylmuramate dehydrogenase) murB yijB b3972 JW3940 yijB murB 37,851 cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; UDP-N-acetylmuramate dehydrogenase activity [GO:0008762]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; UDP-N-acetylmuramate dehydrogenase activity [GO:0008762] GO:0005737; GO:0005829; GO:0007049; GO:0008360; GO:0008762; GO:0009252; GO:0050660; GO:0051301; GO:0071555; GO:0071949 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0ABK9 NRFA_ECOLI Cytochrome c-552 (EC 1.7.2.2) (Ammonia-forming cytochrome c nitrite reductase) (Cytochrome c nitrite reductase) nrfA b4070 JW4031 nrfA 53,703 anaerobic electron transport chain [GO:0019645]; nitrate assimilation [GO:0042128] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; calcium ion binding [GO:0005509]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; nitric oxide reductase activity [GO:0016966]; nitrite reductase (cytochrome, ammonia-forming) activity [GO:0042279]; anaerobic electron transport chain [GO:0019645]; nitrate assimilation [GO:0042128] calcium ion binding [GO:0005509]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; nitric oxide reductase activity [GO:0016966]; nitrite reductase (cytochrome, ammonia-forming) activity [GO:0042279] GO:0005506; GO:0005509; GO:0016966; GO:0019645; GO:0020037; GO:0030288; GO:0042128; GO:0042279 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:11863430, ECO:0000269|PubMed:7934939, ECO:0000269|PubMed:9593308}. +P77747 OMPN_ECOLI Outer membrane porin N (Outer membrane protein N) (Porin OmpN) ompN ynaG b1377 JW1371 ynaG ompN 41,220 carbohydrate transmembrane transport [GO:0034219] cell outer membrane [GO:0009279]; membrane [GO:0016020]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; membrane [GO:0016020]; pore complex [GO:0046930]; porin activity [GO:0015288]; carbohydrate transmembrane transport [GO:0034219] porin activity [GO:0015288] GO:0009279; GO:0015288; GO:0016020; GO:0034219; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein. +P16679 PHNL_ECOLI Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL (RPnTP synthase subunit PhnL) (EC 2.7.8.37) phnL b4096 JW4057 phnL 24,705 organic phosphonate catabolic process [GO:0019700] alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex [GO:0061694] alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex [GO:0061694]; alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity [GO:0061693]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; organic phosphonate catabolic process [GO:0019700] alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity [GO:0061693]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0019700; GO:0042626; GO:0061693; GO:0061694 +P77213 GCS2_ECOLI Putative glutamate--cysteine ligase 2 (EC 6.3.2.2) (Gamma-glutamylcysteine synthetase 2) (GCS 2) (Gamma-GCS 2) ybdK b0581 JW0570 ybdK 41,688 cellular modified amino acid biosynthetic process [GO:0042398] ATP binding [GO:0005524]; glutamate-cysteine ligase activity [GO:0004357]; ligase activity, forming carbon-nitrogen bonds [GO:0016879]; cellular modified amino acid biosynthetic process [GO:0042398] ATP binding [GO:0005524]; glutamate-cysteine ligase activity [GO:0004357]; ligase activity, forming carbon-nitrogen bonds [GO:0016879] GO:0004357; GO:0005524; GO:0016879; GO:0042398 +P0AEP7 GCL_ECOLI Glyoxylate carboligase (EC 4.1.1.47) (Tartronate-semialdehyde synthase) gcl b0507 JW0495 gcl 64,732 glycolate catabolic process [GO:0046296]; glyoxylate catabolic process [GO:0009436]; isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] acetolactate synthase complex [GO:0005948] acetolactate synthase complex [GO:0005948]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; tartronate-semialdehyde synthase activity [GO:0009028]; thiamine pyrophosphate binding [GO:0030976]; glycolate catabolic process [GO:0046296]; glyoxylate catabolic process [GO:0009436]; isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; tartronate-semialdehyde synthase activity [GO:0009028]; thiamine pyrophosphate binding [GO:0030976] GO:0000287; GO:0005948; GO:0009028; GO:0009097; GO:0009099; GO:0009436; GO:0030976; GO:0042802; GO:0046296; GO:0050660; GO:0071949 +P45579 HCXA_ECOLI Hydroxycarboxylate dehydrogenase A (EC 1.1.1.-) (2-oxobutanoate reductase) (2-oxoglutarate reductase) hcxA ybdH b0599 JW0592 ybdH hcxA 39,092 2-hydroxyglutarate dehydrogenase activity [GO:0047545]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] 2-hydroxyglutarate dehydrogenase activity [GO:0047545]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] GO:0016616; GO:0042802; GO:0046872; GO:0047545 +P37353 MENE_ECOLI 2-succinylbenzoate--CoA ligase (EC 6.2.1.26) (o-succinylbenzoyl-CoA synthetase) (OSB-CoA synthetase) menE b2260 JW2255 menE 50,185 menaquinone biosynthetic process [GO:0009234] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; CoA-ligase activity [GO:0016405]; identical protein binding [GO:0042802]; o-succinylbenzoate-CoA ligase activity [GO:0008756]; menaquinone biosynthetic process [GO:0009234] ATP binding [GO:0005524]; CoA-ligase activity [GO:0016405]; identical protein binding [GO:0042802]; o-succinylbenzoate-CoA ligase activity [GO:0008756] GO:0005524; GO:0008756; GO:0009234; GO:0016405; GO:0032991; GO:0042802 +P76264 MNTP_ECOLI Probable manganese efflux pump MntP mntP yebN b1821 JW5830 yebN mntP 20,117 manganese ion transmembrane transport [GO:0071421]; response to manganese ion [GO:0010042] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; manganese ion transmembrane transporter activity [GO:0005384]; manganese ion transmembrane transport [GO:0071421]; response to manganese ion [GO:0010042] manganese ion transmembrane transporter activity [GO:0005384] GO:0005384; GO:0005886; GO:0005887; GO:0010042; GO:0071421 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A9X4 MREB_ECOLI Cell shape-determining protein MreB (Actin-like MreB protein) (Rod shape-determining protein MreB) mreB envB rodY b3251 JW3220 envB rodY mreB 36,952 cell morphogenesis [GO:0000902]; FtsZ-dependent cytokinesis [GO:0043093]; negative regulation of cell division [GO:0051782]; regulation of cell shape [GO:0008360]; regulation of chromosome segregation [GO:0051983] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intrinsic component of plasma membrane [GO:0031226]; plasma membrane [GO:0005886]; polymeric cytoskeletal fiber [GO:0099513] cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intrinsic component of plasma membrane [GO:0031226]; plasma membrane [GO:0005886]; polymeric cytoskeletal fiber [GO:0099513]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; cell morphogenesis [GO:0000902]; FtsZ-dependent cytokinesis [GO:0043093]; negative regulation of cell division [GO:0051782]; regulation of cell shape [GO:0008360]; regulation of chromosome segregation [GO:0051983] ATP binding [GO:0005524]; identical protein binding [GO:0042802] GO:0000902; GO:0005524; GO:0005737; GO:0005856; GO:0005886; GO:0008360; GO:0031226; GO:0042802; GO:0043093; GO:0051782; GO:0051983; GO:0099513 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15612918}. Note=Membrane-associated (PubMed:15612918). Preferentially localizes to regions of negative curvature (PubMed:24550515). May associate with the membrane via MreC (PubMed:15612918). Localization depends on MreC, MreD and RodA (PubMed:15612918). {ECO:0000269|PubMed:15612918, ECO:0000269|PubMed:24550515}. +P0ABH4 MRED_ECOLI Rod shape-determining protein MreD mreD b3249 JW3218 mreD 18,788 regulation of cell shape [GO:0008360] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; regulation of cell shape [GO:0008360] GO:0005886; GO:0005887; GO:0008360 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P09424 MTLD_ECOLI Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17) mtlD b3600 JW3574 mtlD 41,139 mannitol catabolic process [GO:0019592] cytosol [GO:0005829] cytosol [GO:0005829]; mannitol-1-phosphate 5-dehydrogenase activity [GO:0008926]; mannitol catabolic process [GO:0019592] mannitol-1-phosphate 5-dehydrogenase activity [GO:0008926] GO:0005829; GO:0008926; GO:0019592 +P0A6L4 NANA_ECOLI N-acetylneuraminate lyase (NAL) (Neu5Ac lyase) (EC 4.1.3.3) (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (NALase) (Sialate lyase) (Sialic acid aldolase) (Sialic acid lyase) nanA npl b3225 JW3194 npl nanA 32,593 carbohydrate metabolic process [GO:0005975]; N-acetylneuraminate catabolic process [GO:0019262] cytosol [GO:0005829] cytosol [GO:0005829]; identical protein binding [GO:0042802]; N-acetylneuraminate lyase activity [GO:0008747]; carbohydrate metabolic process [GO:0005975]; N-acetylneuraminate catabolic process [GO:0019262] identical protein binding [GO:0042802]; N-acetylneuraminate lyase activity [GO:0008747] GO:0005829; GO:0005975; GO:0008747; GO:0019262; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm. +P31802 NARP_ECOLI Nitrate/nitrite response regulator protein NarP narP b2193 JW2181 narP 23,575 nitrate assimilation [GO:0042128]; phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] ATP binding [GO:0005524]; DNA binding [GO:0003677]; nitrate assimilation [GO:0042128]; phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] ATP binding [GO:0005524]; DNA binding [GO:0003677] GO:0000160; GO:0003677; GO:0005524; GO:0006355; GO:0042128 +P0A752 NADD_ECOLI Nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) (Deamido-NAD(+) diphosphorylase) (Deamido-NAD(+) pyrophosphorylase) (Nicotinate mononucleotide adenylyltransferase) (NaMN adenylyltransferase) nadD ybeN b0639 JW0634 ybeN nadD 24,528 'de novo' NAD biosynthetic process from aspartate [GO:0034628]; NAD biosynthetic process [GO:0009435]; NAD salvage [GO:0034355] ATP binding [GO:0005524]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]; 'de novo' NAD biosynthetic process from aspartate [GO:0034628]; NAD biosynthetic process [GO:0009435]; NAD salvage [GO:0034355] ATP binding [GO:0005524]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515] GO:0000309; GO:0004515; GO:0005524; GO:0009435; GO:0034355; GO:0034628 +P21420 NMPC_ECOLI Putative outer membrane porin protein NmpC nmpC phmA b0553 phmA nmpC 40,302 ion transmembrane transport [GO:0034220] cell outer membrane [GO:0009279]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; pore complex [GO:0046930]; porin activity [GO:0015288]; ion transmembrane transport [GO:0034220] porin activity [GO:0015288] GO:0009279; GO:0015288; GO:0034220; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein. Note=When expressed in mutant CS384. +P0AFG3 ODO1_ECOLI 2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase) sucA b0726 JW0715 sucA 105,062 tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829]; oxoglutarate dehydrogenase complex [GO:0045252] cytosol [GO:0005829]; oxoglutarate dehydrogenase complex [GO:0045252]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976]; tricarboxylic acid cycle [GO:0006099] identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976] GO:0000166; GO:0000287; GO:0004591; GO:0005829; GO:0006099; GO:0030976; GO:0042802; GO:0045252 +P37646 PDEH_ECOLI Cyclic di-GMP phosphodiesterase PdeH (EC 3.1.4.52) pdeH yhjH b3525 JW3493 yhjH pdeH 29,601 regulation of bacterial-type flagellum-dependent cell motility [GO:1902021] cyclic-guanylate-specific phosphodiesterase activity [GO:0071111]; nucleotide binding [GO:0000166]; regulation of bacterial-type flagellum-dependent cell motility [GO:1902021] cyclic-guanylate-specific phosphodiesterase activity [GO:0071111]; nucleotide binding [GO:0000166] GO:0000166; GO:0071111; GO:1902021 +P64461 LSRG_ECOLI (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase (EC 5.3.1.32) (Autoinducer 2-degrading protein LsrG) (AI-2-degrading protein LsrG) (Phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerase) (Phospho-AI-2 isomerase) lsrG yneC b1518 JW1511 yneC lsrG 11,255 cytosol [GO:0005829] cytosol [GO:0005829]; (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity [GO:0002952]; catalytic activity [GO:0003824]; intramolecular oxidoreductase activity, interconverting aldoses and ketoses [GO:0016861]; isomerase activity [GO:0016853]; oxidoreductase activity [GO:0016491] (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity [GO:0002952]; catalytic activity [GO:0003824]; intramolecular oxidoreductase activity, interconverting aldoses and ketoses [GO:0016861]; isomerase activity [GO:0016853]; oxidoreductase activity [GO:0016491] GO:0002952; GO:0003824; GO:0005829; GO:0016491; GO:0016853; GO:0016861 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02051}. +P0ACV0 LPXL_ECOLI Lipid A biosynthesis lauroyltransferase (EC 2.3.1.241) (Kdo(2)-lipid IV(A) lauroyltransferase) lpxL htrB waaM b1054 JW1041 htrB waaM lpxL 35,407 Kdo2-lipid A biosynthetic process [GO:0036104]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; lauroyltransferase activity [GO:0008913]; transferase activity [GO:0016740]; Kdo2-lipid A biosynthetic process [GO:0036104]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide biosynthetic process [GO:0009103] lauroyltransferase activity [GO:0008913]; transferase activity [GO:0016740] GO:0005886; GO:0005887; GO:0008913; GO:0009103; GO:0009245; GO:0016020; GO:0016740; GO:0036104 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01942, ECO:0000269|PubMed:1846149, ECO:0000269|PubMed:18656959, ECO:0000269|PubMed:8662613}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01942}. +P0AD92 LPW_ECOLI trp operon leader peptide trpL trpEE b1265 JW1257 trpEE trpL 1,723 regulation of tryptophan metabolic process [GO:0090357]; tryptophan biosynthetic process [GO:0000162] regulation of tryptophan metabolic process [GO:0090357]; tryptophan biosynthetic process [GO:0000162] GO:0000162; GO:0090357 +P37637 MDTF_ECOLI Multidrug resistance protein MdtF mdtF yhiV b3514 JW3482 yhiV mdtF 111,517 bile acid and bile salt transport [GO:0015721]; drug transmembrane transport [GO:0006855]; response to antibiotic [GO:0046677]; response to toxic substance [GO:0009636]; xenobiotic transport [GO:0042908] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; bile acid transmembrane transporter activity [GO:0015125]; efflux transmembrane transporter activity [GO:0015562]; identical protein binding [GO:0042802]; xenobiotic transmembrane transporter activity [GO:0042910]; bile acid and bile salt transport [GO:0015721]; drug transmembrane transport [GO:0006855]; response to antibiotic [GO:0046677]; response to toxic substance [GO:0009636]; xenobiotic transport [GO:0042908] bile acid transmembrane transporter activity [GO:0015125]; efflux transmembrane transporter activity [GO:0015562]; identical protein binding [GO:0042802]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0006855; GO:0009636; GO:0015125; GO:0015562; GO:0015721; GO:0016020; GO:0016021; GO:0042802; GO:0042908; GO:0042910; GO:0046677 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137}. +P64512 MGRB_ECOLI PhoP/PhoQ regulator MgrB mgrB yobG b1826 JW1815 yobG mgrB 5,552 cellular response to magnesium ion [GO:0071286]; negative regulation of molecular function [GO:0044092]; negative regulation of phosphorelay signal transduction system [GO:0070298]; response to acidic pH [GO:0010447] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cellular response to magnesium ion [GO:0071286]; negative regulation of molecular function [GO:0044092]; negative regulation of phosphorelay signal transduction system [GO:0070298]; response to acidic pH [GO:0010447] GO:0005886; GO:0010447; GO:0016021; GO:0044092; GO:0070298; GO:0071286 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:20041203}; Single-pass membrane protein {ECO:0000305|PubMed:20041203}. +P0AF06 MOTB_ECOLI Motility protein B (Chemotaxis protein MotB) motB b1889 JW1878 motB 34,186 archaeal or bacterial-type flagellum-dependent cell motility [GO:0097588]; chemotaxis [GO:0006935] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; archaeal or bacterial-type flagellum-dependent cell motility [GO:0097588]; chemotaxis [GO:0006935] GO:0005886; GO:0006935; GO:0016021; GO:0097588 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:2447650}; Single-pass type II membrane protein {ECO:0000269|PubMed:2447650}. Note=The OmpA-like domain probably functions to anchor the complex to the cell wall. +P0A8W0 NANR_ECOLI HTH-type transcriptional repressor NanR nanR yhcK b3226 JW3195 yhcK nanR 29,524 negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006351; GO:0045892 +P31600 NFRA_ECOLI Bacteriophage adsorption protein A (Bacteriophage N4 adsorption protein A) nfrA b0568 JW0557 nfrA 111,308 receptor-mediated virion attachment to host cell [GO:0046813] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; receptor-mediated virion attachment to host cell [GO:0046813] GO:0009279; GO:0046813 SUBCELLULAR LOCATION: Cell outer membrane. +P31062 NOHD_ECOLI DNA-packaging protein NU1 homolog nohD nohB b0560 JW0549 nohB nohD 20,428 +P32710 NRFE_ECOLI Probable cytochrome c-type biogenesis protein NrfE nrfE yjcL b4074 JW4035 yjcL nrfE 61,295 cytochrome c-heme linkage via heme-L-cysteine [GO:0018378] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232]; cytochrome c-heme linkage via heme-L-cysteine [GO:0018378] heme binding [GO:0020037]; heme transmembrane transporter activity [GO:0015232] GO:0005886; GO:0015232; GO:0016021; GO:0018378; GO:0020037 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P23843 OPPA_ECOLI Periplasmic oligopeptide-binding protein oppA b1243 JW1235 oppA 60,899 chaperone-mediated protein folding [GO:0061077]; oligopeptide transport [GO:0006857]; peptide transport [GO:0015833]; protein transport [GO:0015031]; response to heat [GO:0009408] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288]; oligopeptide binding [GO:1900750]; peptide transmembrane transporter activity [GO:1904680]; chaperone-mediated protein folding [GO:0061077]; oligopeptide transport [GO:0006857]; peptide transport [GO:0015833]; protein transport [GO:0015031]; response to heat [GO:0009408] oligopeptide binding [GO:1900750]; peptide transmembrane transporter activity [GO:1904680] GO:0006857; GO:0009408; GO:0015031; GO:0015833; GO:0030288; GO:0043190; GO:0061077; GO:1900750; GO:1904680 SUBCELLULAR LOCATION: Periplasm. +P77172 PDEF_ECOLI Cyclic di-GMP phosphodiesterase PdeF (EC 3.1.4.52) pdeF yfgF b2503 JW2488 yfgF pdeF 85,608 cellular response to anoxia [GO:0071454]; cellular response to hydrogen peroxide [GO:0070301]; regulation of single-species biofilm formation [GO:1900190] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cyclic-guanylate-specific phosphodiesterase activity [GO:0071111]; nucleotide binding [GO:0000166]; cellular response to anoxia [GO:0071454]; cellular response to hydrogen peroxide [GO:0070301]; regulation of single-species biofilm formation [GO:1900190] cyclic-guanylate-specific phosphodiesterase activity [GO:0071111]; nucleotide binding [GO:0000166] GO:0000166; GO:0005886; GO:0016021; GO:0070301; GO:0071111; GO:0071454; GO:1900190 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P0ACQ4 OXYR_ECOLI Hydrogen peroxide-inducible genes activator (Morphology and auto-aggregation control protein) oxyR momR mor b3961 JW3933 momR mor oxyR 34,276 cellular response to DNA damage stimulus [GO:0006974]; regulation of DNA-templated transcription, initiation [GO:2000142]; regulation of transcription, DNA-templated [GO:0006355]; response to nitrosative stress [GO:0051409]; response to oxidative stress [GO:0006979] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; cellular response to DNA damage stimulus [GO:0006974]; regulation of DNA-templated transcription, initiation [GO:2000142]; regulation of transcription, DNA-templated [GO:0006355]; response to nitrosative stress [GO:0051409]; response to oxidative stress [GO:0006979] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700] GO:0000986; GO:0003700; GO:0005829; GO:0006355; GO:0006974; GO:0006979; GO:0032993; GO:0051409; GO:2000142 +P02918 PBPA_ECOLI Penicillin-binding protein 1A (PBP-1a) (PBP1a) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)] mrcA ponA b3396 JW3359 ponA mrcA 93,636 cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; penicillin binding [GO:0008658]; peptidoglycan glycosyltransferase activity [GO:0008955]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] penicillin binding [GO:0008658]; peptidoglycan glycosyltransferase activity [GO:0008955]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002] GO:0005886; GO:0008360; GO:0008658; GO:0008955; GO:0009002; GO:0009252; GO:0016021; GO:0046677; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:7006606}; Single-pass type II membrane protein {ECO:0000255}. +P0AC23 FOCA_ECOLI Probable formate transporter 1 (Formate channel 1) focA ycaE b0904 JW0887 ycaE focA 30,991 formate transport [GO:0015724]; mixed acid fermentation [GO:0019664]; response to acidic pH [GO:0010447] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; formate transmembrane transporter activity [GO:0015499]; identical protein binding [GO:0042802]; formate transport [GO:0015724]; mixed acid fermentation [GO:0019664]; response to acidic pH [GO:0010447] formate transmembrane transporter activity [GO:0015499]; identical protein binding [GO:0042802] GO:0005886; GO:0005887; GO:0010447; GO:0015499; GO:0015724; GO:0019664; GO:0042802 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0ABQ2 GARR_ECOLI 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) (Tartronate semialdehyde reductase) (TSAR) garR yhaE b3125 JW5526 yhaE garR 30,427 D-glucarate catabolic process [GO:0042838]; galactarate catabolic process [GO:0046392]; glyoxylate metabolic process [GO:0046487] 2-hydroxy-3-oxopropionate reductase activity [GO:0008679]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; tartronate semialdehyde reductase activity [GO:0103032]; D-glucarate catabolic process [GO:0042838]; galactarate catabolic process [GO:0046392]; glyoxylate metabolic process [GO:0046487] 2-hydroxy-3-oxopropionate reductase activity [GO:0008679]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; tartronate semialdehyde reductase activity [GO:0103032] GO:0008679; GO:0042838; GO:0046392; GO:0046487; GO:0050661; GO:0051287; GO:0103032 +P0AC00 FRLB_ECOLI Fructoselysine 6-phosphate deglycase (EC 3.5.-.-) frlB yhfN b3371 JW5700 yhfN frlB 38,569 fructose 6-phosphate metabolic process [GO:0006002]; protein N-linked glycosylation [GO:0006487]; UDP-N-acetylglucosamine metabolic process [GO:0006047] cytosol [GO:0005829] cytosol [GO:0005829]; carbohydrate derivative binding [GO:0097367]; glutamine-fructose-6-phosphate transaminase (isomerizing) activity [GO:0004360]; hydro-lyase activity [GO:0016836]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; fructose 6-phosphate metabolic process [GO:0006002]; protein N-linked glycosylation [GO:0006487]; UDP-N-acetylglucosamine metabolic process [GO:0006047] carbohydrate derivative binding [GO:0097367]; glutamine-fructose-6-phosphate transaminase (isomerizing) activity [GO:0004360]; hydrolase activity [GO:0016787]; hydro-lyase activity [GO:0016836]; identical protein binding [GO:0042802] GO:0004360; GO:0005829; GO:0006002; GO:0006047; GO:0006487; GO:0016787; GO:0016836; GO:0042802; GO:0097367 +P0A6V8 GLK_ECOLI Glucokinase (EC 2.7.1.2) (Glucose kinase) glk b2388 JW2385 glk 34,723 glycolytic process [GO:0006096] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; glucokinase activity [GO:0004340]; glucose binding [GO:0005536]; glycolytic process [GO:0006096] ATP binding [GO:0005524]; glucokinase activity [GO:0004340]; glucose binding [GO:0005536] GO:0004340; GO:0005524; GO:0005536; GO:0005829; GO:0006096 SUBCELLULAR LOCATION: Cytoplasm. +P09372 GRPE_ECOLI Protein GrpE (HSP-70 cofactor) (HSP24) (Heat shock protein B25.3) grpE b2614 JW2594 grpE 21,798 protein-containing complex assembly [GO:0065003]; protein folding [GO:0006457]; response to heat [GO:0009408] cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; adenyl-nucleotide exchange factor activity [GO:0000774]; chaperone binding [GO:0051087]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; unfolded protein binding [GO:0051082]; protein folding [GO:0006457]; protein-containing complex assembly [GO:0065003]; response to heat [GO:0009408] adenyl-nucleotide exchange factor activity [GO:0000774]; chaperone binding [GO:0051087]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; unfolded protein binding [GO:0051082] GO:0000774; GO:0005737; GO:0005829; GO:0006457; GO:0009408; GO:0019904; GO:0032991; GO:0042803; GO:0051082; GO:0051087; GO:0065003 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P77650 HCAD_ECOLI 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component (EC 1.18.1.3) hcaD hcaA4 phdA yfhY b2542 JW2526 hcaA4 phdA yfhY hcaD 43,978 3-phenylpropionate catabolic process [GO:0019380] 3-phenylpropionate dioxygenase activity [GO:0008695]; ferredoxin-NAD+ reductase activity [GO:0008860]; flavin adenine dinucleotide binding [GO:0050660]; 3-phenylpropionate catabolic process [GO:0019380] 3-phenylpropionate dioxygenase activity [GO:0008695]; ferredoxin-NAD+ reductase activity [GO:0008860]; flavin adenine dinucleotide binding [GO:0050660] GO:0008695; GO:0008860; GO:0019380; GO:0050660 +P0CI31 HCAB_ECOLI 3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase (EC 1.3.1.87) (2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase) (3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase) (CI-dihydrodiol dehydrogenase) (Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase) (Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase) (PP-dihydrodiol dehydrogenase) hcaB phdD yfhX b2541 JW2525 phdD yfhX hcaB 28,500 3-phenylpropionate catabolic process [GO:0019380] 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity [GO:0018498]; 3-phenylpropionate catabolic process [GO:0019380] 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity [GO:0018498] GO:0018498; GO:0019380 +Q47142 HCAT_ECOLI Probable 3-phenylpropionic acid transporter hcaT yfhS b2536 JW2520 yfhS hcaT 41,593 organic substance transport [GO:0071702] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; lactose binding [GO:0030395]; lactose:proton symporter activity [GO:0015528]; organic substance transport [GO:0071702] lactose:proton symporter activity [GO:0015528]; lactose binding [GO:0030395] GO:0005886; GO:0005887; GO:0015528; GO:0030395; GO:0071702 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0ACB4 HEMG_ECOLI Protoporphyrinogen IX dehydrogenase [quinone] (EC 1.3.5.3) (Protoporphyrinogen IX dehydrogenase [menaquinone]) (Protoporphyrinogen IX dehydrogenase [ubiquinone]) (Protoporphyrinogen oxidase) (PPO) hemG yihB b3850 JW3827 yihB hemG 21,226 heme biosynthetic process [GO:0006783]; porphyrin-containing compound biosynthetic process [GO:0006779]; protoporphyrinogen IX biosynthetic process [GO:0006782] cytosol [GO:0005829]; plasma membrane [GO:0005886] cytosol [GO:0005829]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; FMN binding [GO:0010181]; menaquinone-dependent protoporphyrinogen oxidase activity [GO:0070819]; oxygen-dependent protoporphyrinogen oxidase activity [GO:0004729]; heme biosynthetic process [GO:0006783]; porphyrin-containing compound biosynthetic process [GO:0006779]; protoporphyrinogen IX biosynthetic process [GO:0006782] electron transfer activity [GO:0009055]; FMN binding [GO:0010181]; menaquinone-dependent protoporphyrinogen oxidase activity [GO:0070819]; oxygen-dependent protoporphyrinogen oxidase activity [GO:0004729] GO:0004729; GO:0005829; GO:0005886; GO:0006779; GO:0006782; GO:0006783; GO:0009055; GO:0010181; GO:0070819 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00853, ECO:0000305|PubMed:20484676}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00853, ECO:0000305|PubMed:20484676}. +P77682 GTRA_ECOLI Prophage bactoprenol-linked glucose translocase homolog (Bactoprenol-linked glucose translocase homolog from prophage CPS-53) yfdG b2350 JW2346 yfdG 13,226 heme biosynthetic process [GO:0006783]; polysaccharide biosynthetic process [GO:0000271] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; glutamyl-tRNA reductase activity [GO:0008883]; NADP binding [GO:0050661]; heme biosynthetic process [GO:0006783]; polysaccharide biosynthetic process [GO:0000271] glutamyl-tRNA reductase activity [GO:0008883]; NADP binding [GO:0050661] GO:0000271; GO:0005886; GO:0006783; GO:0008883; GO:0016021; GO:0050661 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P63183 KUP_ECOLI Low affinity potassium transport system protein kup (Kup system potassium uptake protein) kup trkD b3747 JW5609 trkD kup 69,294 cellular response to cesium ion [GO:0071278]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; potassium ion transmembrane transporter activity [GO:0015079]; potassium:proton symporter activity [GO:0015387]; cellular response to cesium ion [GO:0071278]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813] potassium:proton symporter activity [GO:0015387]; potassium ion transmembrane transporter activity [GO:0015079] GO:0005886; GO:0005887; GO:0006813; GO:0015079; GO:0015387; GO:0016020; GO:0071278; GO:0071805 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P52095 LDCC_ECOLI Constitutive lysine decarboxylase (LDCC) (EC 4.1.1.18) ldcC ldc ldcH b0186 JW0181 ldc ldcH ldcC 80,590 lysine catabolic process [GO:0006554] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; lysine decarboxylase activity [GO:0008923]; lysine catabolic process [GO:0006554] identical protein binding [GO:0042802]; lysine decarboxylase activity [GO:0008923] GO:0005737; GO:0006554; GO:0008923; GO:0042802 +P52643 LDHD_ECOLI D-lactate dehydrogenase (D-LDH) (EC 1.1.1.28) (Fermentative lactate dehydrogenase) ldhA hslI htpH b1380 JW1375 hslI htpH ldhA 36,535 mixed acid fermentation [GO:0019664]; response to heat [GO:0009408] cytosol [GO:0005829] cytosol [GO:0005829]; D-lactate dehydrogenase activity [GO:0008720]; NADH binding [GO:0070404]; mixed acid fermentation [GO:0019664]; response to heat [GO:0009408] D-lactate dehydrogenase activity [GO:0008720]; NADH binding [GO:0070404] GO:0005829; GO:0008720; GO:0009408; GO:0019664; GO:0070404 +P03061 LPIV_ECOLI ilv operon leader peptide (ilvBN operon attenuator peptide) ivbL b3672 JW3647 ivbL 3,206 branched-chain amino acid biosynthetic process [GO:0009082]; valine biosynthetic process [GO:0009099] branched-chain amino acid biosynthetic process [GO:0009082]; valine biosynthetic process [GO:0009099] GO:0009082; GO:0009099 +P02916 MALF_ECOLI Maltose/maltodextrin transport system permease protein MalF malF b4033 JW3993 malF 57,013 cellular response to DNA damage stimulus [GO:0006974]; maltodextrin transport [GO:0042956]; maltose transport [GO:0015768] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; maltose transport complex [GO:1990060]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; maltose transport complex [GO:1990060]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ABC-type maltose transporter activity [GO:0015423]; cellular response to DNA damage stimulus [GO:0006974]; maltodextrin transport [GO:0042956]; maltose transport [GO:0015768] ABC-type maltose transporter activity [GO:0015423] GO:0005886; GO:0005887; GO:0006974; GO:0015423; GO:0015768; GO:0016020; GO:0042956; GO:0043190; GO:1990060 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:18456666}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:18456666}; Periplasmic side {ECO:0000269|PubMed:18456666}. Note=A substantial portion of it protrudes into the periplasmic space; inserts in an SRP- and Sec-dependent, YidC-independent fashion into the membrane. +P76397 MDTA_ECOLI Multidrug resistance protein MdtA (Multidrug transporter MdtA) mdtA yegM b2074 JW5338 yegM mdtA 44,464 bile acid and bile salt transport [GO:0015721]; xenobiotic transport [GO:0042908] efflux pump complex [GO:1990281]; plasma membrane [GO:0005886] efflux pump complex [GO:1990281]; plasma membrane [GO:0005886]; bile acid transmembrane transporter activity [GO:0015125]; efflux transmembrane transporter activity [GO:0015562]; xenobiotic transmembrane transporter activity [GO:0042910]; bile acid and bile salt transport [GO:0015721]; xenobiotic transport [GO:0042908] bile acid transmembrane transporter activity [GO:0015125]; efflux transmembrane transporter activity [GO:0015562]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0015125; GO:0015562; GO:0015721; GO:0042908; GO:0042910; GO:1990281 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P37330 MASZ_ECOLI Malate synthase G (MSG) (EC 2.3.3.9) glcB glc b2976 JW2943 glc glcB 80,489 glyoxylate catabolic process [GO:0009436]; glyoxylate cycle [GO:0006097]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829] cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; malate synthase activity [GO:0004474]; glyoxylate catabolic process [GO:0009436]; glyoxylate cycle [GO:0006097]; tricarboxylic acid cycle [GO:0006099] magnesium ion binding [GO:0000287]; malate synthase activity [GO:0004474] GO:0000287; GO:0004474; GO:0005829; GO:0006097; GO:0006099; GO:0009436 SUBCELLULAR LOCATION: Cytoplasm. +P0ACH5 MARA_ECOLI Multiple antibiotic resistance protein MarA marA b1531 JW5249 marA 15,184 negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; response to antibiotic [GO:0046677] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; response to antibiotic [GO:0046677] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003677; GO:0003700; GO:0043565; GO:0045892; GO:0045893; GO:0046677 +P37355 MENH_ECOLI 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (SHCHC synthase) (EC 4.2.99.20) menH yfbB b2263 JW2258 yfbB menH 27,682 menaquinone biosynthetic process [GO:0009234] cytosol [GO:0005829] cytosol [GO:0005829]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity [GO:0070205]; menaquinone biosynthetic process [GO:0009234] 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity [GO:0070205] GO:0005829; GO:0009234; GO:0070205 +P0A794 PDXJ_ECOLI Pyridoxine 5'-phosphate synthase (PNP synthase) (EC 2.6.99.2) pdxJ b2564 JW2548 pdxJ 26,384 pyridoxine biosynthetic process [GO:0008615] cytosol [GO:0005829] cytosol [GO:0005829]; identical protein binding [GO:0042802]; pyridoxine 5'-phosphate synthase activity [GO:0033856]; pyridoxine biosynthetic process [GO:0008615] identical protein binding [GO:0042802]; pyridoxine 5'-phosphate synthase activity [GO:0033856] GO:0005829; GO:0008615; GO:0033856; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm. +Q46888 LTND_ECOLI L-threonate dehydrogenase (EC 1.1.1.411) ltnD ygbJ b2736 JW2706 ygbJ ltnD 30,751 carbohydrate metabolic process [GO:0005975] NAD binding [GO:0051287]; NADP binding [GO:0050661]; oxidoreductase activity [GO:0016491]; carbohydrate metabolic process [GO:0005975] NAD binding [GO:0051287]; NADP binding [GO:0050661]; oxidoreductase activity [GO:0016491] GO:0005975; GO:0016491; GO:0050661; GO:0051287 +P0AD96 LIVJ_ECOLI Leu/Ile/Val-binding protein (LIV-BP) livJ b3460 JW3425 livJ 39,076 isoleucine transport [GO:0015818]; leucine transport [GO:0015820]; valine transport [GO:0015829] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; isoleucine transport [GO:0015818]; leucine transport [GO:0015820]; valine transport [GO:0015829] GO:0015818; GO:0015820; GO:0015829; GO:0030288 SUBCELLULAR LOCATION: Periplasm. +P0A9V1 LPTB_ECOLI Lipopolysaccharide export system ATP-binding protein LptB (EC 7.5.2.-) lptB yhbG b3201 JW3168 yhbG lptB 26,801 lipopolysaccharide transport [GO:0015920] ATP-binding cassette (ABC) transporter complex [GO:0043190]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; transporter complex [GO:1990351] ATP-binding cassette (ABC) transporter complex [GO:0043190]; cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; transporter complex [GO:1990351]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipopolysaccharide transport [GO:0015920] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005737; GO:0005886; GO:0015920; GO:0042626; GO:0043190; GO:1990351 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16079137}. Cell inner membrane {ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000269|PubMed:16079137}; Cytoplasmic side {ECO:0000269|PubMed:16079137}. +P0AEZ7 MLTD_ECOLI Membrane-bound lytic murein transglycosylase D (EC 4.2.2.n1) (Murein hydrolase D) (Regulatory protein DniR) mltD dniR yafG b0211 JW5018 dniR yafG mltD 49,417 cell wall organization [GO:0071555]; peptidoglycan metabolic process [GO:0000270]; positive regulation of oxidoreductase activity [GO:0051353] membrane [GO:0016020]; plasma membrane [GO:0005886] membrane [GO:0016020]; plasma membrane [GO:0005886]; lyase activity [GO:0016829]; lytic endotransglycosylase activity [GO:0008932]; lytic transglycosylase activity [GO:0008933]; cell wall organization [GO:0071555]; peptidoglycan metabolic process [GO:0000270]; positive regulation of oxidoreductase activity [GO:0051353] lyase activity [GO:0016829]; lytic endotransglycosylase activity [GO:0008932]; lytic transglycosylase activity [GO:0008933] GO:0000270; GO:0005886; GO:0008932; GO:0008933; GO:0016020; GO:0016829; GO:0051353; GO:0071555 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P11350 NARI_ECOLI Respiratory nitrate reductase 1 gamma chain (EC 1.7.5.1) (Cytochrome B-NR) (Nitrate reductase A subunit gamma) (Quinol-nitrate oxidoreductase subunit gamma) narI chlI b1227 JW1218 chlI narI 25,497 anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061]; nitrate assimilation [GO:0042128] integral component of plasma membrane [GO:0005887]; NarGHI complex [GO:0044799]; nitrate reductase complex [GO:0009325]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; NarGHI complex [GO:0044799]; nitrate reductase complex [GO:0009325]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; nitrate reductase activity [GO:0008940]; anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061]; nitrate assimilation [GO:0042128] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; nitrate reductase activity [GO:0008940] GO:0005886; GO:0005887; GO:0008940; GO:0009055; GO:0009061; GO:0009325; GO:0019645; GO:0020037; GO:0042128; GO:0044799; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P19317 NARW_ECOLI Probable nitrate reductase molybdenum cofactor assembly chaperone NarW (Redox enzyme maturation protein NarW) narW b1466 JW1461 narW 26,161 chaperone-mediated protein complex assembly [GO:0051131]; nitrate assimilation [GO:0042128] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; metallochaperone activity [GO:0016530]; unfolded protein binding [GO:0051082]; chaperone-mediated protein complex assembly [GO:0051131]; nitrate assimilation [GO:0042128] metallochaperone activity [GO:0016530]; unfolded protein binding [GO:0051082] GO:0005737; GO:0016530; GO:0042128; GO:0051082; GO:0051131 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P33934 NAPH_ECOLI Ferredoxin-type protein NapH (Ubiquinol--[NapC cytochrome c] reductase NapH subunit) napH yejZ b2204 JW2192 yejZ napH 31,874 integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0005886; GO:0016020; GO:0016021; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:14674886, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:14674886}. +P13738 NHAA_ECOLI Na(+)/H(+) antiporter NhaA (Sodium/proton antiporter NhaA) nhaA ant b0019 JW0018 ant nhaA 41,356 cellular sodium ion homeostasis [GO:0006883]; regulation of intracellular pH [GO:0051453]; response to cation stress [GO:0043157]; sodium ion export across plasma membrane [GO:0036376] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cardiolipin binding [GO:1901612]; sodium:proton antiporter activity [GO:0015385]; cellular sodium ion homeostasis [GO:0006883]; regulation of intracellular pH [GO:0051453]; response to cation stress [GO:0043157]; sodium ion export across plasma membrane [GO:0036376] cardiolipin binding [GO:1901612]; sodium:proton antiporter activity [GO:0015385] GO:0005886; GO:0005887; GO:0006883; GO:0015385; GO:0036376; GO:0043157; GO:0051453; GO:1901612 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P33602 NUOG_ECOLI NADH-quinone oxidoreductase subunit G (EC 7.1.1.-) (NADH dehydrogenase I subunit G) (NDH-1 subunit G) (NUO7) nuoG b2283 JW2278 nuoG 100,299 aerobic respiration [GO:0009060]; ATP synthesis coupled electron transport [GO:0042773]; cellular respiration [GO:0045333] cytoplasm [GO:0005737]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272] cytoplasm [GO:0005737]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272]; 2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; molybdopterin cofactor binding [GO:0043546]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038]; aerobic respiration [GO:0009060]; ATP synthesis coupled electron transport [GO:0042773]; cellular respiration [GO:0045333] 2 iron, 2 sulfur cluster binding [GO:0051537]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; molybdopterin cofactor binding [GO:0043546]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] GO:0005737; GO:0005886; GO:0008137; GO:0009060; GO:0030964; GO:0042773; GO:0043546; GO:0045272; GO:0045333; GO:0046872; GO:0048038; GO:0051537; GO:0051539 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16079137}. Cell inner membrane {ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000269|PubMed:16079137}. +P0AFD1 NUOE_ECOLI NADH-quinone oxidoreductase subunit E (EC 7.1.1.-) (NADH dehydrogenase I subunit E) (NDH-1 subunit E) (NUO5) nuoE b2285 JW2280 nuoE 18,590 NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272] NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272]; 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; quinone binding [GO:0048038] 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; quinone binding [GO:0048038] GO:0005886; GO:0016491; GO:0030964; GO:0045272; GO:0046872; GO:0048038; GO:0051537 +P64453 ORTT_ECOLI Orphan toxin OrtT ortT ydcX b1445 JW5232 ydcX ortT 6,646 autolysis [GO:0001896] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; autolysis [GO:0001896] GO:0001896; GO:0005887 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:25643179}; Multi-pass membrane protein {ECO:0000305}. +P0A9M2 HPRT_ECOLI Hypoxanthine phosphoribosyltransferase (HPRT) (EC 2.4.2.8) (6-oxopurine phosphoribosyltransferase) (6-oxopurine PRTase) hpt b0125 JW5009 hpt 20,115 adenine salvage [GO:0006168]; GMP salvage [GO:0032263]; guanine salvage [GO:0006178]; hypoxanthine metabolic process [GO:0046100]; IMP salvage [GO:0032264]; protein homotetramerization [GO:0051289] cytosol [GO:0005829] cytosol [GO:0005829]; guanine phosphoribosyltransferase activity [GO:0052657]; guanosine tetraphosphate binding [GO:0097216]; hypoxanthine phosphoribosyltransferase activity [GO:0004422]; magnesium ion binding [GO:0000287]; adenine salvage [GO:0006168]; GMP salvage [GO:0032263]; guanine salvage [GO:0006178]; hypoxanthine metabolic process [GO:0046100]; IMP salvage [GO:0032264]; protein homotetramerization [GO:0051289] guanine phosphoribosyltransferase activity [GO:0052657]; guanosine tetraphosphate binding [GO:0097216]; hypoxanthine phosphoribosyltransferase activity [GO:0004422]; magnesium ion binding [GO:0000287] GO:0000287; GO:0004422; GO:0005829; GO:0006168; GO:0006178; GO:0032263; GO:0032264; GO:0046100; GO:0051289; GO:0052657; GO:0097216 SUBCELLULAR LOCATION: Cytoplasm. +P24232 HMP_ECOLI Flavohemoprotein (Flavohemoglobin) (HMP) (Hemoglobin-like protein) (Nitric oxide dioxygenase) (NO oxygenase) (NOD) (EC 1.14.12.17) hmp fsrB hmpA b2552 JW2536 fsrB hmpA hmp 43,868 cellular response to nitrosative stress [GO:0071500]; nitric oxide catabolic process [GO:0046210]; response to nitrosative stress [GO:0051409]; response to toxic substance [GO:0009636] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; heme binding [GO:0020037]; hydroperoxide reductase activity [GO:0032843]; metal ion binding [GO:0046872]; nitric oxide dioxygenase activity [GO:0008941]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344]; cellular response to nitrosative stress [GO:0071500]; nitric oxide catabolic process [GO:0046210]; response to nitrosative stress [GO:0051409]; response to toxic substance [GO:0009636] FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; heme binding [GO:0020037]; hydroperoxide reductase activity [GO:0032843]; metal ion binding [GO:0046872]; nitric oxide dioxygenase activity [GO:0008941]; oxygen binding [GO:0019825]; oxygen carrier activity [GO:0005344] GO:0005344; GO:0005504; GO:0005737; GO:0008941; GO:0009636; GO:0019825; GO:0020037; GO:0032843; GO:0046210; GO:0046872; GO:0051409; GO:0071500; GO:0071949 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7875569}. Note=Has also been found to localize into the periplasm, but spectral analysis revealed that biochemically active HMP is exclusively found in the cytoplasmic fraction. +Q46822 IDI_ECOLI Isopentenyl-diphosphate Delta-isomerase (IPP isomerase) (EC 5.3.3.2) (IPP:DMAPP isomerase) (Isopentenyl pyrophosphate isomerase) idi ygfV b2889 JW2857 ygfV idi 20,508 cellular response to DNA damage stimulus [GO:0006974]; dimethylallyl diphosphate biosynthetic process [GO:0050992]; isoprenoid biosynthetic process [GO:0008299] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; hydrolase activity [GO:0016787]; isopentenyl-diphosphate delta-isomerase activity [GO:0004452]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270]; cellular response to DNA damage stimulus [GO:0006974]; dimethylallyl diphosphate biosynthetic process [GO:0050992]; isoprenoid biosynthetic process [GO:0008299] hydrolase activity [GO:0016787]; isopentenyl-diphosphate delta-isomerase activity [GO:0004452]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270] GO:0000287; GO:0004452; GO:0005737; GO:0006974; GO:0008270; GO:0008299; GO:0016787; GO:0050992 SUBCELLULAR LOCATION: Cytoplasm. +P0AAC8 ISCA_ECOLI Iron-binding protein IscA (Iron-sulfur cluster assembly protein) iscA yfhF b2528 JW2512 yfhF iscA 11,556 iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; 2 iron, 2 sulfur cluster binding [GO:0051537]; ferrous iron binding [GO:0008198]; iron chaperone activity [GO:0034986]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428] 2 iron, 2 sulfur cluster binding [GO:0051537]; ferrous iron binding [GO:0008198]; iron chaperone activity [GO:0034986] GO:0005737; GO:0005829; GO:0008198; GO:0016226; GO:0034986; GO:0051537; GO:0097428 +P39375 IRAD_ECOLI Anti-adapter protein IraD iraD yjiD b4326 JW5782 yjiD iraD 14,747 cellular response to DNA damage stimulus [GO:0006974]; cellular response to oxidative stress [GO:0034599]; negative regulation of protein catabolic process [GO:0042177] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; anti-sigma factor antagonist activity [GO:0043856]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to oxidative stress [GO:0034599]; negative regulation of protein catabolic process [GO:0042177] anti-sigma factor antagonist activity [GO:0043856] GO:0005737; GO:0006974; GO:0034599; GO:0042177; GO:0043856 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P76323 INTG_ECOLI Putative protein IntG (Putative lambdoid prophage defective integrase) intG b1936 intG 10,732 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] GO:0006310; GO:0015074; GO:0044826; GO:0046718; GO:0075713 +P00803 LEP_ECOLI Signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I) lepB b2568 JW2552 lepB 35,960 protein processing [GO:0016485]; proteolysis [GO:0006508]; signal peptide processing [GO:0006465] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; toxic substance binding [GO:0015643]; protein processing [GO:0016485]; proteolysis [GO:0006508]; signal peptide processing [GO:0006465] endopeptidase activity [GO:0004175]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; toxic substance binding [GO:0015643] GO:0004175; GO:0004252; GO:0005886; GO:0005887; GO:0006465; GO:0006508; GO:0008233; GO:0015643; GO:0016021; GO:0016485 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:21778229}; Multi-pass membrane protein {ECO:0000269|PubMed:21778229}. +P0A7C2 LEXA_ECOLI LexA repressor (EC 3.4.21.88) lexA exrA spr tsl umuA b4043 JW4003 exrA spr tsl umuA lexA 22,358 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; negative regulation of transcription, DNA-templated [GO:0045892]; SOS response [GO:0009432]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; negative regulation of transcription, DNA-templated [GO:0045892]; SOS response [GO:0009432]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0001217; GO:0003677; GO:0004252; GO:0005829; GO:0006260; GO:0006281; GO:0006351; GO:0006974; GO:0009432; GO:0032993; GO:0042802; GO:0045892 +P75957 LOLD_ECOLI Lipoprotein-releasing system ATP-binding protein LolD (EC 7.6.2.-) lolD ycfV b1117 JW5162 ycfV lolD 25,438 lipoprotein localization to outer membrane [GO:0044874]; lipoprotein transport [GO:0042953]; protein localization to outer membrane [GO:0089705]; transmembrane transport [GO:0055085] plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797] plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipoprotein releasing activity [GO:0140306]; transmembrane transporter activity [GO:0022857]; lipoprotein localization to outer membrane [GO:0044874]; lipoprotein transport [GO:0042953]; protein localization to outer membrane [GO:0089705]; transmembrane transport [GO:0055085] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; lipoprotein releasing activity [GO:0140306]; transmembrane transporter activity [GO:0022857] GO:0005524; GO:0005886; GO:0022857; GO:0042626; GO:0042953; GO:0044874; GO:0055085; GO:0089705; GO:0098797; GO:0140306 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. +P0ADV1 LPTA_ECOLI Lipopolysaccharide export system protein LptA lptA yhbN b3200 JW3167 yhbN lptA 20,127 Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; lipopolysaccharide transport [GO:0015920] cell outer membrane [GO:0009279]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; transporter complex [GO:1990351] cell outer membrane [GO:0009279]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; transporter complex [GO:1990351]; glycolipid transfer activity [GO:0017089]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; Gram-negative-bacterium-type cell outer membrane assembly [GO:0043165]; lipopolysaccharide transport [GO:0015920] glycolipid transfer activity [GO:0017089]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530] GO:0001530; GO:0009279; GO:0015920; GO:0017089; GO:0030288; GO:0042597; GO:0042802; GO:0043165; GO:1990351 SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_01914, ECO:0000269|PubMed:17056748, ECO:0000269|PubMed:18480051, ECO:0000269|PubMed:20446753}. Note=Associates with both the inner membrane and the outer membrane. +P0ADF0 LPFS_ECOLI Putative fruR/shl operon leader peptide fruL b0079 fruL 3,291 +P28224 MLIC_ECOLI Membrane-bound lysozyme inhibitor of C-type lysozyme mliC ydhA b1639 JW1631 ydhA mliC 12,568 cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; lysozyme inhibitor activity [GO:0060241] lysozyme inhibitor activity [GO:0060241] GO:0009279; GO:0060241 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:18369469}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000269|PubMed:18369469}. Note=Anchored to the periplasmic side. {ECO:0000269|PubMed:18369469}. +P17109 MEND_ECOLI 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (SEPHCHC synthase) (EC 2.2.1.9) (Menaquinone biosynthesis protein MenD) menD b2264 JW5374 menD 61,367 menaquinone biosynthetic process [GO:0009234] 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity [GO:0070204]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; thiamine pyrophosphate binding [GO:0030976]; menaquinone biosynthetic process [GO:0009234] 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity [GO:0070204]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; thiamine pyrophosphate binding [GO:0030976] GO:0000287; GO:0009234; GO:0030145; GO:0030976; GO:0070204 +P09348 MOTA_ECOLI Motility protein A (Chemotaxis protein MotA) motA flaJ b1890 JW1879 flaJ motA 32,011 bacterial-type flagellum-dependent cell motility [GO:0071973]; bacterial-type flagellum-dependent swarming motility [GO:0071978]; chemotaxis [GO:0006935]; ion transport [GO:0006811] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; bacterial-type flagellum-dependent cell motility [GO:0071973]; bacterial-type flagellum-dependent swarming motility [GO:0071978]; chemotaxis [GO:0006935]; ion transport [GO:0006811] GO:0005886; GO:0006811; GO:0006935; GO:0016021; GO:0071973; GO:0071978 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0ACV6 MPAA_ECOLI Murein peptide amidase A (EC 3.4.17.-) (Gamma-D-Glu-Dap amidase) (Zinc metallocarboxypeptidase MpaA) mpaA ycjI b1326 JW1319 ycjI mpaA 26,558 cell wall macromolecule catabolic process [GO:0016998]; cell wall organization [GO:0071555]; glycopeptide catabolic process [GO:0009050]; peptidoglycan catabolic process [GO:0009253] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; amidase activity [GO:0004040]; murein tripeptide carboxypeptidase activity [GO:0061473]; zinc ion binding [GO:0008270]; cell wall macromolecule catabolic process [GO:0016998]; cell wall organization [GO:0071555]; glycopeptide catabolic process [GO:0009050]; peptidoglycan catabolic process [GO:0009253] amidase activity [GO:0004040]; murein tripeptide carboxypeptidase activity [GO:0061473]; zinc ion binding [GO:0008270] GO:0004040; GO:0005737; GO:0008270; GO:0009050; GO:0009253; GO:0016998; GO:0061473; GO:0071555 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02211, ECO:0000305|PubMed:12511517}. +P0ACR9 MPRA_ECOLI Transcriptional repressor MprA (Protein EmrR) mprA emrR b2684 JW2659 emrR mprA 20,563 negative regulation of transcription, DNA-templated [GO:0045892]; response to antibiotic [GO:0046677]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; response to antibiotic [GO:0046677]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003677; GO:0003700; GO:0005829; GO:0006351; GO:0045892; GO:0046677 +P31060 MODF_ECOLI ABC transporter ATP-binding protein ModF (Photorepair protein PhrA) modF ORF6 phrA b0760 JW0743 ORF6 phrA modF 54,536 DNA repair [GO:0006281] ATP-binding cassette (ABC) transporter complex [GO:0043190] ATP-binding cassette (ABC) transporter complex [GO:0043190]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; DNA repair [GO:0006281] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0006281; GO:0042626; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. +P19624 PDXA_ECOLI 4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262) (4-(phosphohydroxy)-L-threonine dehydrogenase) pdxA b0052 JW0051 pdxA 35,114 pyridoxal phosphate biosynthetic process [GO:0042823]; pyridoxine biosynthetic process [GO:0008615] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 4-hydroxythreonine-4-phosphate dehydrogenase activity [GO:0050570]; cobalt ion binding [GO:0050897]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; zinc ion binding [GO:0008270]; pyridoxal phosphate biosynthetic process [GO:0042823]; pyridoxine biosynthetic process [GO:0008615] 4-hydroxythreonine-4-phosphate dehydrogenase activity [GO:0050570]; cobalt ion binding [GO:0050897]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; NAD binding [GO:0051287]; zinc ion binding [GO:0008270] GO:0000287; GO:0005737; GO:0008270; GO:0008615; GO:0042802; GO:0042823; GO:0050570; GO:0050897; GO:0051287 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00536}. +P09126 HEM4_ECOLI Uroporphyrinogen-III synthase (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) hemD b3804 JW3776 hemD 27,798 protoporphyrinogen IX biosynthetic process [GO:0006782]; uroporphyrinogen III biosynthetic process [GO:0006780] uroporphyrinogen-III synthase activity [GO:0004852]; protoporphyrinogen IX biosynthetic process [GO:0006782]; uroporphyrinogen III biosynthetic process [GO:0006780] uroporphyrinogen-III synthase activity [GO:0004852] GO:0004852; GO:0006780; GO:0006782 +P0ACJ0 LRP_ECOLI Leucine-responsive regulatory protein lrp alsB ihb livR oppI b0889 JW0872 alsB ihb livR oppI lrp 18,887 alanine catabolic process [GO:0006524]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; response to amino acid [GO:0043200]; response to leucine [GO:0043201] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; alanine catabolic process [GO:0006524]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; response to amino acid [GO:0043200]; response to leucine [GO:0043201] DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0001216; GO:0001217; GO:0005829; GO:0006355; GO:0006524; GO:0032993; GO:0042802; GO:0043200; GO:0043201; GO:0043565; GO:0045892 +P27300 LPXK_ECOLI Tetraacyldisaccharide 4'-kinase (EC 2.7.1.130) (Lipid A 4'-kinase) lpxK ycaH b0915 JW0898 ycaH lpxK 35,589 lipid A biosynthetic process [GO:0009245]; lipopolysaccharide core region biosynthetic process [GO:0009244] membrane [GO:0016020]; plasma membrane [GO:0005886] membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; tetraacyldisaccharide 4'-kinase activity [GO:0009029]; lipid A biosynthetic process [GO:0009245]; lipopolysaccharide core region biosynthetic process [GO:0009244] ATP binding [GO:0005524]; kinase activity [GO:0016301]; tetraacyldisaccharide 4'-kinase activity [GO:0009029] GO:0005524; GO:0005886; GO:0009029; GO:0009244; GO:0009245; GO:0016020; GO:0016301 +P0AB38 LPOB_ECOLI Penicillin-binding protein activator LpoB (PBP activator LpoB) (Lipoprotein activator of PBP from the outer membrane B) lpoB ycfM b1105 JW5157 ycfM lpoB 22,516 peptidoglycan biosynthetic process [GO:0009252]; positive regulation of catalytic activity [GO:0043085]; regulation of cell shape [GO:0008360] cell outer membrane [GO:0009279]; periplasmic side of cell outer membrane [GO:0031241] cell outer membrane [GO:0009279]; periplasmic side of cell outer membrane [GO:0031241]; enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; enzyme regulator activity [GO:0030234]; peptidoglycan biosynthetic process [GO:0009252]; positive regulation of catalytic activity [GO:0043085]; regulation of cell shape [GO:0008360] enzyme activator activity [GO:0008047]; enzyme binding [GO:0019899]; enzyme regulator activity [GO:0030234] GO:0008047; GO:0008360; GO:0009252; GO:0009279; GO:0019899; GO:0030234; GO:0031241; GO:0043085 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:21183073, ECO:0000269|PubMed:21183074}; Lipid-anchor {ECO:0000269|PubMed:21183073, ECO:0000269|PubMed:21183074}; Periplasmic side {ECO:0000269|PubMed:21183073, ECO:0000269|PubMed:21183074}. Note=Localizes to the divisome and to the lateral wall. +P61889 MDH_ECOLI Malate dehydrogenase (EC 1.1.1.37) mdh b3236 JW3205 mdh 32,337 anaerobic respiration [GO:0009061]; fermentation [GO:0006113]; glycolytic process [GO:0006096]; malate metabolic process [GO:0006108]; tricarboxylic acid cycle [GO:0006099] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; membrane [GO:0016020] cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; membrane [GO:0016020]; L-malate dehydrogenase activity [GO:0030060]; malate dehydrogenase activity [GO:0016615]; oxidoreductase activity [GO:0016491]; anaerobic respiration [GO:0009061]; fermentation [GO:0006113]; glycolytic process [GO:0006096]; malate metabolic process [GO:0006108]; tricarboxylic acid cycle [GO:0006099] L-malate dehydrogenase activity [GO:0030060]; malate dehydrogenase activity [GO:0016615]; oxidoreductase activity [GO:0016491] GO:0005737; GO:0005829; GO:0006096; GO:0006099; GO:0006108; GO:0006113; GO:0009061; GO:0016020; GO:0016491; GO:0016615; GO:0019898; GO:0030060 +P39285 MSCM_ECOLI Miniconductance mechanosensitive channel MscM mscM yjeP b4159 JW4120 yjeP mscM 123,968 ion transport [GO:0006811]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ion transport [GO:0006811]; transmembrane transport [GO:0055085] GO:0005886; GO:0006811; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:22874652}; Multi-pass membrane protein {ECO:0000269|PubMed:22874652}. +P54746 MNGB_ECOLI Mannosylglycerate hydrolase (EC 3.2.1.-) (2-O-(6-phospho-mannosyl)-D-glycerate hydrolase) (Alpha-mannosidase mngB) mngB ybgG b0732 JW0721 ybgG mngB 100,015 mannose metabolic process [GO:0006013]; oligosaccharide catabolic process [GO:0009313] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; mannose metabolic process [GO:0006013]; oligosaccharide catabolic process [GO:0009313] alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872] GO:0004559; GO:0006013; GO:0009313; GO:0030246; GO:0046872 +P54745 MNGA_ECOLI PTS system 2-O-alpha-mannosyl-D-glycerate-specific EIIABC component (2-O-alpha-mannosyl-D-glycerate-specific phosphotransferase enzyme MngA) (Protein-Npi-phosphohistidine--2-O-alpha-mannosyl-D-glycerate phosphotransferase) [Includes: 2-O-alpha-mannosyl-D-glycerate-specific phosphotransferase enzyme IIA component (PTS system EIIA component); 2-O-alpha-mannosyl-D-glycerate-specific phosphotransferase enzyme IIB component (EC 2.7.1.195) (PTS system EIIB component); 2-O-alpha-mannosyl-D-glycerate-specific permease IIC component (PTS system EIIC component)] mngA hrsA b0731 JW0720 hrsA mngA 69,668 mannosylglycerate transport [GO:0051476]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; carbohydrate:proton symporter activity [GO:0005351]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity [GO:0022877]; protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity [GO:0090581]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; mannosylglycerate transport [GO:0051476]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] carbohydrate:proton symporter activity [GO:0005351]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity [GO:0022877]; protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity [GO:0090581]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005351; GO:0005886; GO:0005887; GO:0009401; GO:0016301; GO:0022877; GO:0051476; GO:0090563; GO:0090581 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00427, ECO:0000305|PubMed:14645248}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00427, ECO:0000305|PubMed:14645248}. +P32701 PDEC_ECOLI Probable cyclic di-GMP phosphodiesterase PdeC (EC 3.1.4.52) pdeC yjcC b4061 JW4022 yjcC pdeC 60,801 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cyclic-guanylate-specific phosphodiesterase activity [GO:0071111] cyclic-guanylate-specific phosphodiesterase activity [GO:0071111] GO:0005886; GO:0016021; GO:0071111 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P76346 MTFA_ECOLI Protein MtfA (Mlc titration factor A) mtfA yeeI b1976 JW1958 yeeI mtfA 30,279 negative regulation of DNA-binding transcription factor activity [GO:0043433]; regulation of DNA-binding transcription factor activity [GO:0051090] cytosol [GO:0005829] cytosol [GO:0005829]; aminopeptidase activity [GO:0004177]; metallopeptidase activity [GO:0008237]; transcription factor binding [GO:0008134]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; regulation of DNA-binding transcription factor activity [GO:0051090] aminopeptidase activity [GO:0004177]; metallopeptidase activity [GO:0008237]; transcription factor binding [GO:0008134] GO:0004177; GO:0005829; GO:0008134; GO:0008237; GO:0043433; GO:0051090 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16855233}. +P14900 MURD_ECOLI UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamic acid-adding enzyme) (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase) murD b0088 JW0086 murD 46,974 cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; UDP-N-acetylmuramoylalanine-D-glutamate ligase activity [GO:0008764]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; UDP-N-acetylmuramoylalanine-D-glutamate ligase activity [GO:0008764] GO:0005524; GO:0005737; GO:0007049; GO:0008360; GO:0008764; GO:0009252; GO:0042802; GO:0051301; GO:0071555 SUBCELLULAR LOCATION: Cytoplasm. +P0AF18 NAGA_ECOLI N-acetylglucosamine-6-phosphate deacetylase (GlcNAc 6-P deacetylase) (EC 3.5.1.25) nagA b0677 JW0663 nagA 40,949 carbohydrate metabolic process [GO:0005975]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; protein homotetramerization [GO:0051289] N-acetylgalactosamine-6-phosphate deacetylase activity [GO:0047419]; N-acetylglucosamine-6-phosphate deacetylase activity [GO:0008448]; zinc ion binding [GO:0008270]; carbohydrate metabolic process [GO:0005975]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; protein homotetramerization [GO:0051289] N-acetylgalactosamine-6-phosphate deacetylase activity [GO:0047419]; N-acetylglucosamine-6-phosphate deacetylase activity [GO:0008448]; zinc ion binding [GO:0008270] GO:0005975; GO:0006046; GO:0008270; GO:0008448; GO:0019262; GO:0047419; GO:0051289 +P33594 NIKE_ECOLI Nickel import ATP-binding protein NikE (EC 7.2.2.11) nikE b3480 JW3445 nikE 29,722 cellular response to DNA damage stimulus [GO:0006974]; nickel cation transmembrane transport [GO:0035444] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ABC-type nickel transporter activity [GO:0015413]; ATP binding [GO:0005524]; nickel cation binding [GO:0016151]; cellular response to DNA damage stimulus [GO:0006974]; nickel cation transmembrane transport [GO:0035444] ABC-type nickel transporter activity [GO:0015413]; ATP binding [GO:0005524]; nickel cation binding [GO:0016151] GO:0005524; GO:0005886; GO:0006974; GO:0015413; GO:0016151; GO:0035444 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01712}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01712}. +P0AFB8 NTRC_ECOLI DNA-binding transcriptional regulator NtrC (Nitrogen regulation protein NR(I)) (Nitrogen regulator I) (NRI) glnG glnT ntrC b3868 JW3839 glnT ntrC glnG 52,255 nitrogen fixation [GO:0009399]; regulation of nitrogen utilization [GO:0006808]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; phosphorelay response regulator activity [GO:0000156]; sequence-specific DNA binding [GO:0043565]; transcription factor binding [GO:0008134]; nitrogen fixation [GO:0009399]; regulation of nitrogen utilization [GO:0006808]; regulation of transcription, DNA-templated [GO:0006355] ATP binding [GO:0005524]; phosphorelay response regulator activity [GO:0000156]; sequence-specific DNA binding [GO:0043565]; transcription factor binding [GO:0008134] GO:0000156; GO:0005524; GO:0005829; GO:0006355; GO:0006808; GO:0008134; GO:0009399; GO:0043565 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P31979 NUOF_ECOLI NADH-quinone oxidoreductase subunit F (EC 7.1.1.-) (NADH dehydrogenase I subunit F) (NDH-1 subunit F) (NUO6) nuoF b2284 JW2279 nuoF 49,292 aerobic respiration [GO:0009060]; cellular respiration [GO:0045333] NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272] NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272]; 4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038]; aerobic respiration [GO:0009060]; cellular respiration [GO:0045333] 4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; NAD binding [GO:0051287]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] GO:0005886; GO:0008137; GO:0009060; GO:0010181; GO:0030964; GO:0045272; GO:0045333; GO:0046872; GO:0048038; GO:0051287; GO:0051539 +P0AFG8 ODP1_ECOLI Pyruvate dehydrogenase E1 component (PDH E1 component) (EC 1.2.4.1) aceE b0114 JW0110 aceE 99,668 glycolytic process [GO:0006096] cytosol [GO:0005829]; cytosolic pyruvate dehydrogenase complex [GO:0045250]; membrane [GO:0016020] cytosol [GO:0005829]; cytosolic pyruvate dehydrogenase complex [GO:0045250]; membrane [GO:0016020]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739]; pyruvate dehydrogenase activity [GO:0004738]; thiamine pyrophosphate binding [GO:0030976]; glycolytic process [GO:0006096] identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739]; pyruvate dehydrogenase activity [GO:0004738]; thiamine pyrophosphate binding [GO:0030976] GO:0000287; GO:0004738; GO:0004739; GO:0005829; GO:0006096; GO:0016020; GO:0030976; GO:0042802; GO:0042803; GO:0045250 +P31057 PANB_ECOLI 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) (Ketopantoate hydroxymethyltransferase) (KPHMT) panB b0134 JW0130 panB 28,237 pantothenate biosynthetic process [GO:0015940] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; 3-methyl-2-oxobutanoate hydroxymethyltransferase activity [GO:0003864]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; pantothenate biosynthetic process [GO:0015940] 3-methyl-2-oxobutanoate hydroxymethyltransferase activity [GO:0003864]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287] GO:0000287; GO:0003864; GO:0005737; GO:0005829; GO:0015940; GO:0016020; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P36678 GSPM_ECOLI Putative type II secretion system protein M (T2SS protein M) (Putative general secretion pathway protein M) (Transport protein PshM) gspM hopZ pshM b3334 JW5704 hopZ pshM gspM 17,234 protein secretion by the type II secretion system [GO:0015628] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627]; protein secretion by the type II secretion system [GO:0015628] GO:0005886; GO:0015627; GO:0015628; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:P25061}; Single-pass membrane protein {ECO:0000250|UniProtKB:P25061}. +P0A6V5 GLPE_ECOLI Thiosulfate sulfurtransferase GlpE (EC 2.8.1.1) glpE b3425 JW3388 glpE 12,082 glycerol metabolic process [GO:0006071] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; thiosulfate sulfurtransferase activity [GO:0004792]; glycerol metabolic process [GO:0006071] thiosulfate sulfurtransferase activity [GO:0004792] GO:0004792; GO:0005737; GO:0006071 SUBCELLULAR LOCATION: Cytoplasm. +P23893 GSA_ECOLI Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (EC 5.4.3.8) (Glutamate-1-semialdehyde aminotransferase) (GSA-AT) hemL gsa popC b0154 JW0150 gsa popC hemL 45,366 porphyrin-containing compound biosynthetic process [GO:0006779]; protoporphyrinogen IX biosynthetic process [GO:0006782]; tetrapyrrole biosynthetic process [GO:0033014] cytosol [GO:0005829] cytosol [GO:0005829]; glutamate-1-semialdehyde 2,1-aminomutase activity [GO:0042286]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]; porphyrin-containing compound biosynthetic process [GO:0006779]; protoporphyrinogen IX biosynthetic process [GO:0006782]; tetrapyrrole biosynthetic process [GO:0033014] glutamate-1-semialdehyde 2,1-aminomutase activity [GO:0042286]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] GO:0005829; GO:0006779; GO:0006782; GO:0008483; GO:0030170; GO:0033014; GO:0042286; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P23331 KITH_ECOLI Thymidine kinase (EC 2.7.1.21) tdk b1238 JW1226 tdk 23,457 DNA biosynthetic process [GO:0071897]; dTMP salvage [GO:0036198]; thymidine metabolic process [GO:0046104] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; thymidine kinase activity [GO:0004797]; zinc ion binding [GO:0008270]; DNA biosynthetic process [GO:0071897]; dTMP salvage [GO:0036198]; thymidine metabolic process [GO:0046104] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; thymidine kinase activity [GO:0004797]; zinc ion binding [GO:0008270] GO:0004797; GO:0005524; GO:0005829; GO:0008270; GO:0036198; GO:0042802; GO:0046104; GO:0071897 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00124}. +P22731 LIVF_ECOLI High-affinity branched-chain amino acid transport ATP-binding protein LivF (LIV-I protein F) livF b3454 JW3419 livF 26,310 branched-chain amino acid transport [GO:0015803]; isoleucine transmembrane transport [GO:1903714]; L-amino acid transport [GO:0015807]; L-valine transmembrane transport [GO:1903785]; phenylalanine transport [GO:0015823] ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; branched-chain amino acid transmembrane transporter activity [GO:0015658]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-valine transmembrane transporter activity [GO:0005304]; branched-chain amino acid transport [GO:0015803]; isoleucine transmembrane transport [GO:1903714]; L-amino acid transport [GO:0015807]; L-valine transmembrane transport [GO:1903785]; phenylalanine transport [GO:0015823] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; branched-chain amino acid transmembrane transporter activity [GO:0015658]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-valine transmembrane transporter activity [GO:0005304] GO:0005304; GO:0005524; GO:0015188; GO:0015658; GO:0015803; GO:0015807; GO:0015823; GO:0042626; GO:1903714; GO:1903785 +P0ACL7 LLDR_ECOLI Putative L-lactate dehydrogenase operon regulatory protein lldR lctR b3604 JW3579 lctR lldR 29,166 cellular response to DNA damage stimulus [GO:0006974] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; cellular response to DNA damage stimulus [GO:0006974] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0006974; GO:0043565 +P0AE72 MAZE_ECOLI Antitoxin MazE mazE chpAI chpR b2783 JW2754 chpAI chpR mazE 9,356 protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; double-stranded DNA binding [GO:0003690]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; toxin-antitoxin pair type II binding [GO:0097351] double-stranded DNA binding [GO:0003690]; protein-containing complex binding [GO:0044877]; protein homodimerization activity [GO:0042803]; toxin-antitoxin pair type II binding [GO:0097351] GO:0003690; GO:0032991; GO:0042803; GO:0044877; GO:0097351 +P02921 MELB_ECOLI Melibiose carrier protein (Melibiose permease) (Melibiose transporter) (Na+ (Li+)/melibiose symporter) (Thiomethylgalactoside permease II) melB mel-4 b4120 JW4081 mel-4 melB 52,636 melibiose transport [GO:0015769]; methylgalactoside transport [GO:0015765]; organic substance transport [GO:0071702] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; melibiose:cation symporter activity [GO:0015487]; melibiose:sodium symporter activity [GO:0043887]; methylgalactoside transmembrane transporter activity [GO:0015592]; melibiose transport [GO:0015769]; methylgalactoside transport [GO:0015765]; organic substance transport [GO:0071702] melibiose:cation symporter activity [GO:0015487]; melibiose:sodium symporter activity [GO:0043887]; methylgalactoside transmembrane transporter activity [GO:0015592] GO:0005886; GO:0005887; GO:0015487; GO:0015592; GO:0015765; GO:0015769; GO:0043887; GO:0071702 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:7703254}; Multi-pass membrane protein {ECO:0000269|PubMed:7703254}. +P30749 MOAE_ECOLI Molybdopterin synthase catalytic subunit (EC 2.8.1.12) (MPT synthase subunit 2) (Molybdenum cofactor biosynthesis protein E) (Molybdopterin-converting factor large subunit) (Molybdopterin-converting factor subunit 2) moaE chlA5 b0785 JW0768 chlA5 moaE 16,981 Mo-molybdopterin cofactor biosynthetic process [GO:0006777] cytosol [GO:0005829] cytosol [GO:0005829]; molybdopterin synthase activity [GO:0030366]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777] molybdopterin synthase activity [GO:0030366] GO:0005829; GO:0006777; GO:0030366 +P32173 MOBA_ECOLI Molybdenum cofactor guanylyltransferase (MoCo guanylyltransferase) (EC 2.7.7.77) (GTP:molybdopterin guanylyltransferase) (Mo-MPT guanylyltransferase) (Molybdopterin guanylyltransferase) (Molybdopterin-guanine dinucleotide biosynthesis protein A) (Molybdopterin-guanine dinucleotide synthase) (MGD synthase) (Protein FA) mobA chlB mob narB b3857 JW3829 chlB mob narB mobA 21,643 bis(molybdopterin guanine dinucleotide)molybdenum biosynthetic process [GO:1902758] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; molybdenum cofactor guanylyltransferase activity [GO:0061603]; nucleotidyltransferase activity [GO:0016779]; bis(molybdopterin guanine dinucleotide)molybdenum biosynthetic process [GO:1902758] GTP binding [GO:0005525]; magnesium ion binding [GO:0000287]; molybdenum cofactor guanylyltransferase activity [GO:0061603]; nucleotidyltransferase activity [GO:0016779] GO:0000287; GO:0005525; GO:0005737; GO:0016779; GO:0061603; GO:1902758 SUBCELLULAR LOCATION: Cytoplasm. +P24202 MRR_ECOLI Mrr restriction system protein (EcoKMrr) mrr b4351 JW4314 mrr 33,520 DNA restriction-modification system [GO:0009307]; response to hydrostatic pressure [GO:0051599] bacterial nucleoid [GO:0043590] bacterial nucleoid [GO:0043590]; DNA binding [GO:0003677]; restriction endodeoxyribonuclease activity [GO:0015666]; type IV site-specific deoxyribonuclease activity [GO:0032067]; DNA restriction-modification system [GO:0009307]; response to hydrostatic pressure [GO:0051599] DNA binding [GO:0003677]; restriction endodeoxyribonuclease activity [GO:0015666]; type IV site-specific deoxyribonuclease activity [GO:0032067] GO:0003677; GO:0009307; GO:0015666; GO:0032067; GO:0043590; GO:0051599 +P45425 NANK_ECOLI N-acetylmannosamine kinase (EC 2.7.1.60) (ManNAc kinase) (N-acetyl-D-mannosamine kinase) nanK yhcI b3222 JW5538 yhcI nanK 29,644 cellular response to DNA damage stimulus [GO:0006974]; N-acetylmannosamine metabolic process [GO:0006051]; N-acetylneuraminate catabolic process [GO:0019262] ATP binding [GO:0005524]; N-acylmannosamine kinase activity [GO:0009384]; zinc ion binding [GO:0008270]; cellular response to DNA damage stimulus [GO:0006974]; N-acetylmannosamine metabolic process [GO:0006051]; N-acetylneuraminate catabolic process [GO:0019262] ATP binding [GO:0005524]; N-acylmannosamine kinase activity [GO:0009384]; zinc ion binding [GO:0008270] GO:0005524; GO:0006051; GO:0006974; GO:0008270; GO:0009384; GO:0019262 +P0AAL3 NAPG_ECOLI Ferredoxin-type protein NapG (Ubiquinol--[NapC cytochrome c] reductase NapG subunit) napG yojA yojB b2205 JW2193 yojA yojB napG 24,925 periplasmic space [GO:0042597]; plasma membrane [GO:0005886] periplasmic space [GO:0042597]; plasma membrane [GO:0005886]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0005886; GO:0042597; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:14674886}. +P0AAL0 NAPF_ECOLI Ferredoxin-type protein NapF napF yojG b2208 JW2196 yojG napF 18,047 response to oxidative stress [GO:0006979] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; response to oxidative stress [GO:0006979] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0005737; GO:0006979; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17074894}. Note=Loosely attached to the inner side of the membrane. {ECO:0000269|PubMed:17074894}. +P06722 MUTH_ECOLI DNA mismatch repair protein MutH (Methyl-directed mismatch repair protein) mutH mutR prv b2831 JW2799 mutR prv mutH 25,527 DNA modification [GO:0006304]; mismatch repair [GO:0006298]; regulation of DNA recombination [GO:0000018] cytoplasm [GO:0005737]; mismatch repair complex [GO:0032300] cytoplasm [GO:0005737]; mismatch repair complex [GO:0032300]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; T/G mismatch-specific endonuclease activity [GO:0043765]; DNA modification [GO:0006304]; mismatch repair [GO:0006298]; regulation of DNA recombination [GO:0000018] DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; T/G mismatch-specific endonuclease activity [GO:0043765] GO:0000018; GO:0003677; GO:0004519; GO:0005737; GO:0006298; GO:0006304; GO:0032300; GO:0043765 SUBCELLULAR LOCATION: Cytoplasm. +P76007 NHAP2_ECOLI K(+)/H(+) antiporter NhaP2 (Potassium/proton antiporter NhaP2) cvrA nhaP2 ycgO b1191 JW5184 nhaP2 ycgO cvrA 62,285 cell volume homeostasis [GO:0006884] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; flavin adenine dinucleotide binding [GO:0050660]; potassium:proton antiporter activity [GO:0015386]; cell volume homeostasis [GO:0006884] flavin adenine dinucleotide binding [GO:0050660]; potassium:proton antiporter activity [GO:0015386] GO:0005886; GO:0005887; GO:0006884; GO:0015386; GO:0050660 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01075}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01075}. +P23898 NLPC_ECOLI Probable endopeptidase NlpC (EC 3.4.-.-) (ORF-17) (Probable lipoprotein NlpC) nlpC b1708 JW1698 nlpC 17,283 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; cysteine-type peptidase activity [GO:0008234] cysteine-type peptidase activity [GO:0008234] GO:0005886; GO:0008234 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P03014 PINE_ECOLI Serine recombinase PinE (EC 3.1.22.-) (EC 6.5.1.-) (DNA-invertase PinE) (DNA-invertase from lambdoid prophage e14) (Site-specific recombinase PinE) pinE pin b1158 JW1144 pin pinE 20,573 DNA integration [GO:0015074]; DNA recombination [GO:0006310] DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; ligase activity [GO:0016874]; recombinase activity [GO:0000150]; DNA integration [GO:0015074]; DNA recombination [GO:0006310] DNA binding [GO:0003677]; hydrolase activity [GO:0016787]; ligase activity [GO:0016874]; recombinase activity [GO:0000150] GO:0000150; GO:0003677; GO:0006310; GO:0015074; GO:0016787; GO:0016874 +P76611 PINH_ECOLI Putative protein PinH (Putative DNA-invertase from prophage CP4-44) pinH b2648 JW5423 pinH 5,438 DNA integration [GO:0015074] DNA binding [GO:0003677]; recombinase activity [GO:0000150]; DNA integration [GO:0015074] DNA binding [GO:0003677]; recombinase activity [GO:0000150] GO:0000150; GO:0003677; GO:0015074 +P0A8G6 NQOR_ECOLI NAD(P)H dehydrogenase (quinone) (EC 1.6.5.2) (Flavoprotein WrbA) (NAD(P)H:quinone oxidoreductase) (NQO) wrbA b1004 JW0989 wrbA 20,846 response to oxidative stress [GO:0006979] cytosol [GO:0005829]; membrane [GO:0016020]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; NADH dehydrogenase (quinone) activity [GO:0050136]; NADP binding [GO:0050661]; NADPH dehydrogenase (quinone) activity [GO:0008753]; response to oxidative stress [GO:0006979] flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; identical protein binding [GO:0042802]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955]; NAD binding [GO:0051287]; NADH dehydrogenase (quinone) activity [GO:0050136]; NADP binding [GO:0050661]; NADPH dehydrogenase (quinone) activity [GO:0008753] GO:0003955; GO:0005829; GO:0006979; GO:0008753; GO:0010181; GO:0016020; GO:0032991; GO:0042802; GO:0050136; GO:0050660; GO:0050661; GO:0051287 +P0AFJ7 PITA_ECOLI Low-affinity inorganic phosphate transporter 1 pitA pit b3493 JW3460 pit pitA 53,389 magnesium ion homeostasis [GO:0010960]; phosphate ion transmembrane transport [GO:0035435]; tellurite transport [GO:0015710] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; inorganic phosphate transmembrane transporter activity [GO:0005315]; solute:proton symporter activity [GO:0015295]; tellurite transmembrane transporter activity [GO:0015654]; zinc ion transmembrane transporter activity [GO:0005385]; magnesium ion homeostasis [GO:0010960]; phosphate ion transmembrane transport [GO:0035435]; tellurite transport [GO:0015710] inorganic phosphate transmembrane transporter activity [GO:0005315]; solute:proton symporter activity [GO:0015295]; tellurite transmembrane transporter activity [GO:0015654]; zinc ion transmembrane transporter activity [GO:0005385] GO:0005315; GO:0005385; GO:0005886; GO:0005887; GO:0010960; GO:0015295; GO:0015654; GO:0015710; GO:0035435 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P43676 PITB_ECOLI Probable low-affinity inorganic phosphate transporter 2 pitB b2987 JW2955 pitB 53,809 phosphate ion transmembrane transport [GO:0035435] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; inorganic phosphate transmembrane transporter activity [GO:0005315]; phosphate ion transmembrane transport [GO:0035435] inorganic phosphate transmembrane transporter activity [GO:0005315] GO:0005315; GO:0005886; GO:0005887; GO:0016021; GO:0035435 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P07000 PLDB_ECOLI Lysophospholipase L2 (EC 3.1.1.5) (Lecithinase B) pldB b3825 JW5584 pldB 38,978 lipid metabolic process [GO:0006629] membrane [GO:0016020]; plasma membrane [GO:0005886] membrane [GO:0016020]; plasma membrane [GO:0005886]; lipase activity [GO:0016298]; lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747]; lipid metabolic process [GO:0006629] lipase activity [GO:0016298]; lysophospholipase activity [GO:0004622]; phosphatidyl phospholipase B activity [GO:0102545]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] GO:0004622; GO:0005886; GO:0006629; GO:0016020; GO:0016298; GO:0016747; GO:0102545 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. +P0ABC7 HFLK_ECOLI Modulator of FtsH protease HflK hflK hflA b4174 JW4132 hflA hflK 45,545 negative regulation of catalytic activity [GO:0043086]; response to heat [GO:0009408] cytosol [GO:0005829]; integral component of external side of plasma membrane [GO:0071575]; membrane protein complex [GO:0098796] cytosol [GO:0005829]; integral component of external side of plasma membrane [GO:0071575]; membrane protein complex [GO:0098796]; negative regulation of catalytic activity [GO:0043086]; response to heat [GO:0009408] GO:0005829; GO:0009408; GO:0043086; GO:0071575; GO:0098796 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:8947034}; Single-pass type II membrane protein {ECO:0000269|PubMed:8947034}. +P60664 HIS6_ECOLI Imidazole glycerol phosphate synthase subunit HisF (EC 4.3.2.10) (IGP synthase cyclase subunit) (IGP synthase subunit HisF) (ImGP synthase subunit HisF) (IGPS subunit HisF) hisF b2025 JW2007 hisF 28,454 histidine biosynthetic process [GO:0000105] cytosol [GO:0005829]; imidazoleglycerol-phosphate synthase complex [GO:0009382] cytosol [GO:0005829]; imidazoleglycerol-phosphate synthase complex [GO:0009382]; imidazoleglycerol-phosphate synthase activity [GO:0000107]; lyase activity [GO:0016829]; histidine biosynthetic process [GO:0000105] imidazoleglycerol-phosphate synthase activity [GO:0000107]; lyase activity [GO:0016829] GO:0000105; GO:0000107; GO:0005829; GO:0009382; GO:0016829 SUBCELLULAR LOCATION: Cytoplasm. +P25666 HTRL_ECOLI Protein HtrL htrL yibB b3618 JW5644 yibB htrL 33,458 +P08142 ILVB_ECOLI Acetolactate synthase isozyme 1 large subunit (AHAS-I) (EC 2.2.1.6) (Acetohydroxy-acid synthase I large subunit) (ALS-I) ilvB b3671 JW3646 ilvB 60,441 isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] acetolactate synthase complex [GO:0005948] acetolactate synthase complex [GO:0005948]; acetolactate synthase activity [GO:0003984]; flavin adenine dinucleotide binding [GO:0050660]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976]; isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] acetolactate synthase activity [GO:0003984]; flavin adenine dinucleotide binding [GO:0050660]; magnesium ion binding [GO:0000287]; thiamine pyrophosphate binding [GO:0030976] GO:0000287; GO:0003984; GO:0005948; GO:0009097; GO:0009099; GO:0030976; GO:0050660 +A0A385XJE6 INH21_ECOLI Transposase InsH for insertion sequence element IS5U insH21 b4711 insH21 37,851 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P76542 INTZ_ECOLI Prophage integrase IntZ (Putative prophage CPZ-55 integrase) intZ b2442 intZ 45,382 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0044826; GO:0046718; GO:0075713 +P0ADF8 ILVN_ECOLI Acetolactate synthase isozyme 1 small subunit (EC 2.2.1.6) (Acetohydroxy-acid synthase I small subunit) (AHAS-I) (ALS-I) ilvN b3670 JW3645 ilvN 11,106 isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] acetolactate synthase complex [GO:0005948] acetolactate synthase complex [GO:0005948]; acetolactate synthase activity [GO:0003984]; acetolactate synthase regulator activity [GO:1990610]; isoleucine biosynthetic process [GO:0009097]; valine biosynthetic process [GO:0009099] acetolactate synthase activity [GO:0003984]; acetolactate synthase regulator activity [GO:1990610] GO:0003984; GO:0005948; GO:0009097; GO:0009099; GO:1990610 +P0CE52 INSH4_ECOLI Transposase InsH for insertion sequence element IS5F insH4 b1331 JW1324 insH4 37,851 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CF82 INSF4_ECOLI Transposase InsF for insertion sequence IS3D insF4 b1026 JW1012 insF4 33,540 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0032196 +P28306 MLTG_ECOLI Endolytic murein transglycosylase (EC 4.2.2.-) (Peptidoglycan polymerization terminase) mltG yceG b1097 JW1083 yceG mltG 38,247 cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan metabolic process [GO:0000270] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; lyase activity [GO:0016829]; lytic endotransglycosylase activity [GO:0008932]; lytic transglycosylase activity [GO:0008933]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan metabolic process [GO:0000270] lyase activity [GO:0016829]; lytic endotransglycosylase activity [GO:0008932]; lytic transglycosylase activity [GO:0008933] GO:0000270; GO:0005886; GO:0005887; GO:0008932; GO:0008933; GO:0009252; GO:0016829; GO:0030288; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02065, ECO:0000269|PubMed:26507882}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02065, ECO:0000269|PubMed:26507882}. +P37773 MPL_ECOLI UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase (EC 6.3.2.45) (Murein peptide ligase) (UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase) mpl yjfG b4233 JW4192 yjfG mpl 49,874 cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan turnover [GO:0009254]; regulation of cell shape [GO:0008360] cytoplasm [GO:0005737]; extracellular region [GO:0005576] cytoplasm [GO:0005737]; extracellular region [GO:0005576]; acid-amino acid ligase activity [GO:0016881]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan turnover [GO:0009254]; regulation of cell shape [GO:0008360] acid-amino acid ligase activity [GO:0016881]; ATP binding [GO:0005524]; identical protein binding [GO:0042802] GO:0005524; GO:0005576; GO:0005737; GO:0007049; GO:0008360; GO:0009252; GO:0009254; GO:0016881; GO:0042802; GO:0051301; GO:0071555 SUBCELLULAR LOCATION: Secreted. +P77348 MPPA_ECOLI Periplasmic murein peptide-binding protein mppA ynaH b1329 JW1322 ynaH mppA 59,900 peptide transport [GO:0015833]; protein transport [GO:0015031]; tripeptide transport [GO:0042939] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; oligopeptide binding [GO:1900750]; peptide transmembrane transporter activity [GO:1904680]; peptide transport [GO:0015833]; protein transport [GO:0015031]; tripeptide transport [GO:0042939] oligopeptide binding [GO:1900750]; peptide transmembrane transporter activity [GO:1904680] GO:0015031; GO:0015833; GO:0030288; GO:0042597; GO:0042939; GO:0043190; GO:1900750; GO:1904680 SUBCELLULAR LOCATION: Periplasm. +Q46810 MOCA_ECOLI Molybdenum cofactor cytidylyltransferase (MoCo cytidylyltransferase) (EC 2.7.7.76) (CTP:molybdopterin cytidylyltransferase) (Mo-MPT cytidylyltransferase) (Molybdopterin cytidylyltransferase) (Molybdopterin-cytosine dinucleotide synthase) (MCD synthase) mocA ygfJ b2877 JW2845 ygfJ mocA 21,514 Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process [GO:1902760]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777] magnesium ion binding [GO:0000287]; molybdenum cofactor cytidylyltransferase activity [GO:0061602]; nucleotide binding [GO:0000166]; Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process [GO:1902760]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777] magnesium ion binding [GO:0000287]; molybdenum cofactor cytidylyltransferase activity [GO:0061602]; nucleotide binding [GO:0000166] GO:0000166; GO:0000287; GO:0006777; GO:0061602; GO:1902760 +P10903 NARK_ECOLI Nitrate/nitrite transporter NarK (Nitrite extrusion protein 1) (Nitrite facilitator 1) narK b1223 JW1214 narK 49,693 nitrate assimilation [GO:0042128]; nitrate transport [GO:0015706]; nitrite transport [GO:0015707] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; inorganic anion exchanger activity [GO:0005452]; nitrate transmembrane transporter activity [GO:0015112]; nitrite efflux transmembrane transporter activity [GO:0015514]; nitrate assimilation [GO:0042128]; nitrate transport [GO:0015706]; nitrite transport [GO:0015707] inorganic anion exchanger activity [GO:0005452]; nitrate transmembrane transporter activity [GO:0015112]; nitrite efflux transmembrane transporter activity [GO:0015514] GO:0005452; GO:0005886; GO:0005887; GO:0015112; GO:0015514; GO:0015706; GO:0015707; GO:0042128 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0ABL5 NAPC_ECOLI Cytochrome c-type protein NapC napC yejX b2202 JW2190 yejX napC 23,101 anaerobic respiration [GO:0009061]; denitrification pathway [GO:0019333] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; anaerobic respiration [GO:0009061]; denitrification pathway [GO:0019333] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872] GO:0005886; GO:0009055; GO:0009061; GO:0016021; GO:0019333; GO:0020037; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein. +P0ADL1 NEPI_ECOLI Purine ribonucleoside efflux pump NepI nepI yicM b3662 JW5938 yicM nepI 41,842 purine nucleoside transmembrane transport [GO:0015860] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; purine nucleoside transmembrane transporter activity [GO:0015211]; purine nucleoside transmembrane transport [GO:0015860] purine nucleoside transmembrane transporter activity [GO:0015211] GO:0005886; GO:0015211; GO:0015860; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A6X3 HFQ_ECOLI RNA-binding protein Hfq (HF-1) (Host factor-I protein) (HF-I) hfq b4172 JW4130 hfq 11,166 negative regulation of translation, ncRNA-mediated [GO:0040033]; positive regulation of translation, ncRNA-mediated [GO:0045975]; regulation of RNA stability [GO:0043487]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation, ncRNA-mediated [GO:0045974] cytosol [GO:0005829] cytosol [GO:0005829]; bent DNA binding [GO:0003681]; RNA binding [GO:0003723]; negative regulation of translation, ncRNA-mediated [GO:0040033]; positive regulation of translation, ncRNA-mediated [GO:0045975]; regulation of RNA stability [GO:0043487]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation, ncRNA-mediated [GO:0045974] bent DNA binding [GO:0003681]; RNA binding [GO:0003723] GO:0003681; GO:0003723; GO:0005829; GO:0006355; GO:0040033; GO:0043487; GO:0045974; GO:0045975 +P19931 HYAE_ECOLI Hydrogenase-1 operon protein HyaE hyaE b0976 JW0958 hyaE 14,890 signal sequence binding [GO:0005048] signal sequence binding [GO:0005048] GO:0005048 +P77668 HYFI_ECOLI Hydrogenase-4 component I (EC 1.-.-.-) hyfI b2489 JW5805 hyfI 28,101 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] GO:0008137; GO:0046872; GO:0048038; GO:0051539 +P0AAP5 IPRA_ECOLI Inhibitor of hydrogen peroxide resistance iprA yaiV b0375 JW0366 yaiV iprA 23,956 response to oxidative stress [GO:0006979] response to oxidative stress [GO:0006979] GO:0006979 +P24218 INTD_ECOLI Prophage integrase IntD (Prophage DLP12 integrase) (Prophage QSR' integrase) intD int b0537 JW0525 int intD 45,090 viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; prophage integrase activity [GO:0008979]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA binding [GO:0003677]; prophage integrase activity [GO:0008979] GO:0003677; GO:0005829; GO:0008979; GO:0044826; GO:0046718 +P0CF27 INSB3_ECOLI Insertion element IS1 3 protein InsB (IS1c) insB3 b0274 JW0268 insB3 19,758 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CE51 INSH3_ECOLI Transposase InsH for insertion sequence element IS5D insH3 b0656 JW0652 insH3 37,851 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CF66 INSE1_ECOLI Transposase InsE for insertion sequence IS3A insE1 b0298 JW5036 insE1 11,543 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +A0A385XJ53 INSA9_ECOLI Insertion element IS1 9 protein InsA (IS1 repressor TnpA) insA9 b4709 insA9 9,868 transposition, DNA-mediated [GO:0006313] transposition, DNA-mediated [GO:0006313] GO:0006313 +P0CF67 INSE2_ECOLI Transposase InsE for insertion sequence IS3B insE2 b0373 JW5050 insE2 11,543 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CE53 INSH6_ECOLI Transposase InsH for insertion sequence element IS5H insH6 b1994 JW1972 insH6 37,823 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CF25 INSB1_ECOLI Insertion element IS1 1 protein InsB (IS1a) insB1 b0021 JW0020 insB1 19,565 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P03835 INSG_ECOLI Transposase InsG for insertion sequence element IS4 insG b4278 JW5767 insG 50,386 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CE50 INSH2_ECOLI Transposase InsH for insertion sequence element IS5B insH2 b0552 JW0540 insH2 37,851 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P21599 KPYK2_ECOLI Pyruvate kinase II (EC 2.7.1.40) (PK-2) pykA b1854 JW1843 pykA 51,357 glycolytic process [GO:0006096] cytoplasm [GO:0005737]; cytosol [GO:0005829]; pyruvate kinase complex [GO:1902912] cytoplasm [GO:0005737]; cytosol [GO:0005829]; pyruvate kinase complex [GO:1902912]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743]; glycolytic process [GO:0006096] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; potassium ion binding [GO:0030955]; pyruvate kinase activity [GO:0004743] GO:0000287; GO:0004743; GO:0005524; GO:0005737; GO:0005829; GO:0006096; GO:0016301; GO:0030955; GO:0042802; GO:1902912 +P0AFB5 NTRB_ECOLI Sensory histidine kinase/phosphatase NtrB (EC 2.7.13.3) (EC 3.1.3.-) (Nitrogen regulation protein NR(II)) (Nitrogen regulator II) (NRII) glnL glnR ntrB b3869 JW3840 glnR ntrB glnL 38,556 nitrogen fixation [GO:0009399]; protein autophosphorylation [GO:0046777]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155]; nitrogen fixation [GO:0009399]; protein autophosphorylation [GO:0046777]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155] GO:0000155; GO:0004721; GO:0005524; GO:0005737; GO:0006355; GO:0007165; GO:0009399; GO:0042802; GO:0046777; GO:0051171 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:15157101}. +P0A772 NRDI_ECOLI Protein NrdI nrdI ygaO b2674 JW2649 ygaO nrdI 15,340 cellular protein modification process [GO:0006464] FMN binding [GO:0010181]; cellular protein modification process [GO:0006464] FMN binding [GO:0010181] GO:0006464; GO:0010181 +P45799 NUDE_ECOLI ADP compounds hydrolase NudE (EC 3.6.1.-) nudE yrfE b3397 JW3360 yrfE nudE 21,153 nucleoside phosphate metabolic process [GO:0006753]; ribose phosphate metabolic process [GO:0019693] cytosol [GO:0005829] cytosol [GO:0005829]; ADP-ribose diphosphatase activity [GO:0047631]; ADP-sugar diphosphatase activity [GO:0019144]; magnesium ion binding [GO:0000287]; nucleoside phosphate metabolic process [GO:0006753]; ribose phosphate metabolic process [GO:0019693] ADP-ribose diphosphatase activity [GO:0047631]; ADP-sugar diphosphatase activity [GO:0019144]; magnesium ion binding [GO:0000287] GO:0000287; GO:0005829; GO:0006753; GO:0019144; GO:0019693; GO:0047631 +P75920 OPGC_ECOLI Glucans biosynthesis protein C (EC 2.1.-.-) mdoC opgC ymdD b1047 JW1034 opgC ymdD mdoC 44,690 glucan biosynthetic process [GO:0009250]; oligosaccharide metabolic process [GO:0009311] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; succinyltransferase activity [GO:0016748]; transferase activity, transferring one-carbon groups [GO:0016741]; glucan biosynthetic process [GO:0009250]; oligosaccharide metabolic process [GO:0009311] succinyltransferase activity [GO:0016748]; transferase activity, transferring one-carbon groups [GO:0016741] GO:0005886; GO:0009250; GO:0009311; GO:0016021; GO:0016741; GO:0016748 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0AFG6 ODO2_ECOLI Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) sucB b0727 JW0716 sucB 44,011 L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829]; oxoglutarate dehydrogenase complex [GO:0045252] cytosol [GO:0005829]; oxoglutarate dehydrogenase complex [GO:0045252]; dihydrolipoyllysine-residue succinyltransferase activity [GO:0004149]; lipoic acid binding [GO:0031405]; L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; tricarboxylic acid cycle [GO:0006099] dihydrolipoyllysine-residue succinyltransferase activity [GO:0004149]; lipoic acid binding [GO:0031405] GO:0004149; GO:0005829; GO:0006099; GO:0031405; GO:0033512; GO:0045252 +P0AEH5 ELAB_ECOLI Protein ElaB elaB yfbD b2266 JW2261 yfbD elaB 11,306 cellular response to DNA damage stimulus [GO:0006974] cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887] cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; ribosome binding [GO:0043022]; cellular response to DNA damage stimulus [GO:0006974] ribosome binding [GO:0043022] GO:0005829; GO:0005887; GO:0006974; GO:0043022 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P25552 GPPA_ECOLI Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC 3.6.1.40) (Guanosine pentaphosphate phosphohydrolase) (pppGpp-5'-phosphohydrolase) gppA gpp b3779 JW5603 gpp gppA 54,871 guanosine pentaphosphate catabolic process [GO:0015974]; guanosine tetraphosphate biosynthetic process [GO:0015970]; nucleobase-containing small molecule interconversion [GO:0015949]; phosphorus metabolic process [GO:0006793]; response to starvation [GO:0042594] guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity [GO:0008894]; pyrophosphatase activity [GO:0016462]; guanosine pentaphosphate catabolic process [GO:0015974]; guanosine tetraphosphate biosynthetic process [GO:0015970]; nucleobase-containing small molecule interconversion [GO:0015949]; phosphorus metabolic process [GO:0006793]; response to starvation [GO:0042594] guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity [GO:0008894]; pyrophosphatase activity [GO:0016462] GO:0006793; GO:0008894; GO:0015949; GO:0015970; GO:0015974; GO:0016462; GO:0042594 +P0AEQ3 GLNH_ECOLI Glutamine-binding periplasmic protein (GlnBP) glnH b0811 JW0796 glnH 27,190 amino acid transport [GO:0006865] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; ligand-gated ion channel activity [GO:0015276]; amino acid transport [GO:0006865] ligand-gated ion channel activity [GO:0015276] GO:0006865; GO:0015276; GO:0016020; GO:0030288 SUBCELLULAR LOCATION: Periplasm {ECO:0000305|PubMed:3027504}. +P0AC55 GLNK_ECOLI Nitrogen regulatory protein GlnK (Nitrogen regulatory protein P-II 2) (PII-like protein) glnK ybaI b0450 JW0440 ybaI glnK 12,259 positive regulation of nitrogen utilization [GO:0045848]; regulation of nitrogen utilization [GO:0006808] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; enzyme regulator activity [GO:0030234]; identical protein binding [GO:0042802]; positive regulation of nitrogen utilization [GO:0045848]; regulation of nitrogen utilization [GO:0006808] ATP binding [GO:0005524]; enzyme regulator activity [GO:0030234]; identical protein binding [GO:0042802] GO:0005524; GO:0005829; GO:0006808; GO:0030234; GO:0042802; GO:0045848 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11847102, ECO:0000269|PubMed:14668330, ECO:0000269|PubMed:16864585}. Cell inner membrane {ECO:0000269|PubMed:11847102, ECO:0000269|PubMed:14668330, ECO:0000269|PubMed:16864585}. Note=During nitrogen limitation, GlnK is predominantly in its fully uridylylated state in the cytoplasmic fraction. In response to nitrogen shock, GlnK is deuridylylated rapidly and associates tightly with AmtB in the inner membrane. {ECO:0000269|PubMed:11847102, ECO:0000269|PubMed:14668330, ECO:0000269|PubMed:16864585}. +P0AER0 GLPF_ECOLI Glycerol uptake facilitator protein (Aquaglyceroporin) glpF b3927 JW3898 glpF 29,780 cellular response to mercury ion [GO:0071288]; glycerol transport [GO:0015793]; water transport [GO:0006833] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; glycerol channel activity [GO:0015254]; glycerol transmembrane transporter activity [GO:0015168]; metal ion binding [GO:0046872]; cellular response to mercury ion [GO:0071288]; glycerol transport [GO:0015793]; water transport [GO:0006833] glycerol channel activity [GO:0015254]; glycerol transmembrane transporter activity [GO:0015168]; metal ion binding [GO:0046872] GO:0005886; GO:0006833; GO:0015168; GO:0015254; GO:0015793; GO:0016021; GO:0046872; GO:0071288 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P03825 GSPB_ECOLI Putative general secretion pathway protein B gspB pinO pioO pno b3322 JW3284 pinO pioO pno gspB 15,876 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. +P03023 LACI_ECOLI Lactose operon repressor lacI b0345 JW0336 lacI 38,590 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription repressor activity [GO:0001217]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0000986; GO:0001217; GO:0003700; GO:0005829; GO:0006355; GO:0042802; GO:0045892 +P0ABR9 MHPB_ECOLI 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase (EC 1.13.11.16) (3-carboxyethylcatechol 2,3-dioxygenase) mhpB b0348 JW0339 mhpB 34,196 3-(3-hydroxy)phenylpropionate catabolic process [GO:0019622]; 3-phenylpropionate catabolic process [GO:0019380]; phenylpropanoid catabolic process [GO:0046271] 3-carboxyethylcatechol 2,3-dioxygenase activity [GO:0047070]; ferrous iron binding [GO:0008198]; 3-(3-hydroxy)phenylpropionate catabolic process [GO:0019622]; 3-phenylpropionate catabolic process [GO:0019380]; phenylpropanoid catabolic process [GO:0046271] 3-carboxyethylcatechol 2,3-dioxygenase activity [GO:0047070]; ferrous iron binding [GO:0008198] GO:0008198; GO:0019380; GO:0019622; GO:0046271; GO:0047070 +P76506 MLAA_ECOLI Intermembrane phospholipid transport system lipoprotein MlaA mlaA vacJ b2346 JW2343 vacJ mlaA 28,042 intermembrane phospholipid transfer [GO:0120010] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; intermembrane phospholipid transfer [GO:0120010] GO:0009279; GO:0120010 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305|PubMed:19383799}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000305|PubMed:19383799}. +P64606 MLAE_ECOLI Intermembrane phospholipid transport system permease protein MlaE mlaE yrbE b3194 JW3161 yrbE mlaE 27,863 phospholipid transport [GO:0015914] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; phospholipid transporter activity [GO:0005548]; phospholipid transport [GO:0015914] phospholipid transporter activity [GO:0005548] GO:0005548; GO:0005886; GO:0015914; GO:0032991; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000305|PubMed:19383799}; Multi-pass membrane protein {ECO:0000255, ECO:0000305|PubMed:19383799}. +P33358 MLRA_ECOLI HTH-type transcriptional regulator MlrA (MerR-like regulator A) mlrA yehV b2127 JW2115 yehV mlrA 28,046 DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700 +P41036 NANT_ECOLI Sialic acid transporter NanT (Sialic acid permease) (Sialic acid/H(+) symporter) nanT b3224 JW3193 nanT 53,551 carboxylic acid transport [GO:0046942]; sialic acid transport [GO:0015739] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; carbohydrate:proton symporter activity [GO:0005351]; carboxylic acid transmembrane transporter activity [GO:0046943]; sialic acid transmembrane transporter activity [GO:0015136]; sialic acid:proton symporter activity [GO:0015538]; carboxylic acid transport [GO:0046942]; sialic acid transport [GO:0015739] carbohydrate:proton symporter activity [GO:0005351]; carboxylic acid transmembrane transporter activity [GO:0046943]; sialic acid:proton symporter activity [GO:0015538]; sialic acid transmembrane transporter activity [GO:0015136] GO:0005351; GO:0005886; GO:0005887; GO:0015136; GO:0015538; GO:0015739; GO:0046942; GO:0046943 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01238, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01238}. +P09152 NARG_ECOLI Respiratory nitrate reductase 1 alpha chain (EC 1.7.5.1) (Nitrate reductase A subunit alpha) (Quinol-nitrate oxidoreductase subunit alpha) narG bisD narC b1224 JW1215 bisD narC narG 140,489 anaerobic respiration [GO:0009061]; nitrate assimilation [GO:0042128]; nitrate metabolic process [GO:0042126] intrinsic component of membrane [GO:0031224]; intrinsic component of the cytoplasmic side of the plasma membrane [GO:0031235]; membrane [GO:0016020]; NarGHI complex [GO:0044799] intrinsic component of membrane [GO:0031224]; intrinsic component of the cytoplasmic side of the plasma membrane [GO:0031235]; membrane [GO:0016020]; NarGHI complex [GO:0044799]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; molybdopterin cofactor binding [GO:0043546]; nitrate reductase activity [GO:0008940]; anaerobic respiration [GO:0009061]; nitrate assimilation [GO:0042128]; nitrate metabolic process [GO:0042126] 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; molybdopterin cofactor binding [GO:0043546]; nitrate reductase activity [GO:0008940] GO:0008940; GO:0009055; GO:0009061; GO:0016020; GO:0031224; GO:0031235; GO:0042126; GO:0042128; GO:0043546; GO:0044799; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. +P23367 MUTL_ECOLI DNA mismatch repair protein MutL mutL b4170 JW4128 mutL 67,924 mismatch repair [GO:0006298]; regulation of DNA recombination [GO:0000018] mismatch repair complex [GO:0032300] mismatch repair complex [GO:0032300]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mismatched DNA binding [GO:0030983]; mismatch repair [GO:0006298]; regulation of DNA recombination [GO:0000018] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; mismatched DNA binding [GO:0030983] GO:0000018; GO:0003677; GO:0005524; GO:0006298; GO:0016887; GO:0030983; GO:0032300; GO:0042802 +P17117 NFSA_ECOLI Oxygen-insensitive NADPH nitroreductase (EC 1.-.-.-) (Modulator of drug activity A) nfsA mda18 mdaA ybjB b0851 JW0835 mda18 mdaA ybjB nfsA 26,801 cytosol [GO:0005829] cytosol [GO:0005829]; chromate reductase activity [GO:0034567]; FMN binding [GO:0010181]; oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [GO:0016657] chromate reductase activity [GO:0034567]; FMN binding [GO:0010181]; oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [GO:0016657] GO:0005829; GO:0010181; GO:0016657; GO:0034567 +P31450 GLVG_ECOLI Putative inactive 6-phospho-alpha-glucosidase glvG b4556 b3681 glvG 23,724 carbohydrate metabolic process [GO:0005975] hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; carbohydrate metabolic process [GO:0005975] hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] GO:0004553; GO:0005975; GO:0016616; GO:0046872 +P77161 GLXR_ECOLI 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) (Tartronate semialdehyde reductase) (TSAR) glxR glxB1 ybbQ b0509 JW0497 glxB1 ybbQ glxR 30,801 allantoin assimilation pathway [GO:0009442]; cellular response to DNA damage stimulus [GO:0006974]; glycolate catabolic process [GO:0046296]; glyoxylate catabolic process [GO:0009436] 2-hydroxy-3-oxopropionate reductase activity [GO:0008679]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; tartronate semialdehyde reductase activity [GO:0103032]; allantoin assimilation pathway [GO:0009442]; cellular response to DNA damage stimulus [GO:0006974]; glycolate catabolic process [GO:0046296]; glyoxylate catabolic process [GO:0009436] 2-hydroxy-3-oxopropionate reductase activity [GO:0008679]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; tartronate semialdehyde reductase activity [GO:0103032] GO:0006974; GO:0008679; GO:0009436; GO:0009442; GO:0046296; GO:0050661; GO:0051287; GO:0103032 +P52101 GLRK_ECOLI Sensor histidine kinase GlrK (EC 2.7.13.3) glrK yfhK b2556 JW5407 yfhK glrK 53,330 osmosensory signaling via phosphorelay pathway [GO:0007234]; protein autophosphorylation [GO:0046777]; response to epinephrine [GO:0071871]; signal transduction [GO:0007165] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphorelay response regulator activity [GO:0000156]; phosphorelay sensor kinase activity [GO:0000155]; protein kinase activator activity [GO:0030295]; osmosensory signaling via phosphorelay pathway [GO:0007234]; protein autophosphorylation [GO:0046777]; response to epinephrine [GO:0071871]; signal transduction [GO:0007165] ATP binding [GO:0005524]; phosphorelay response regulator activity [GO:0000156]; phosphorelay sensor kinase activity [GO:0000155]; protein kinase activator activity [GO:0030295] GO:0000155; GO:0000156; GO:0005524; GO:0005886; GO:0007165; GO:0007234; GO:0016021; GO:0030295; GO:0046777; GO:0071871 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A6W0 GLSA2_ECOLI Glutaminase 2 (EC 3.5.1.2) glsA2 yneH b1524 JW1517 yneH glsA2 33,516 glutamate biosynthetic process [GO:0006537]; glutamine catabolic process [GO:0006543]; negative regulation of growth [GO:0045926] glutaminase activity [GO:0004359]; glutamate biosynthetic process [GO:0006537]; glutamine catabolic process [GO:0006543]; negative regulation of growth [GO:0045926] glutaminase activity [GO:0004359] GO:0004359; GO:0006537; GO:0006543; GO:0045926 +P77454 GLSA1_ECOLI Glutaminase 1 (EC 3.5.1.2) glsA1 ybaS b0485 JW0474 ybaS glsA1 32,903 glutamate biosynthetic process [GO:0006537]; glutamine catabolic process [GO:0006543]; negative regulation of growth [GO:0045926]; response to acidic pH [GO:0010447] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; glutaminase activity [GO:0004359]; glutamate biosynthetic process [GO:0006537]; glutamine catabolic process [GO:0006543]; negative regulation of growth [GO:0045926]; response to acidic pH [GO:0010447] glutaminase activity [GO:0004359] GO:0004359; GO:0006537; GO:0006543; GO:0010447; GO:0032991; GO:0045926 +P17115 GUTQ_ECOLI Arabinose 5-phosphate isomerase GutQ (API) (G-API) (EC 5.3.1.13) (Phosphosugar aldol-ketol isomerase) gutQ srlQ b2708 JW5431 srlQ gutQ 34,031 keto-3-deoxy-D-manno-octulosonic acid biosynthetic process [GO:0019294] arabinose-5-phosphate isomerase activity [GO:0019146]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; keto-3-deoxy-D-manno-octulosonic acid biosynthetic process [GO:0019294] arabinose-5-phosphate isomerase activity [GO:0019146]; ATP binding [GO:0005524]; metal ion binding [GO:0046872] GO:0005524; GO:0019146; GO:0019294; GO:0046872 +P37651 GUN_ECOLI Endoglucanase (EC 3.2.1.4) (Carboxymethylcellulase) (CMCase) (Cellulase) (Endo-1,4-beta-glucanase) bcsZ bcsC yhjM b3531 JW3499 bcsC yhjM bcsZ 41,700 cellulose catabolic process [GO:0030245] extracellular region [GO:0005576] extracellular region [GO:0005576]; cellulase activity [GO:0008810]; cellulose catabolic process [GO:0030245] cellulase activity [GO:0008810] GO:0005576; GO:0008810; GO:0030245 SUBCELLULAR LOCATION: Secreted. +P21865 KDPD_ECOLI Sensor protein KdpD (EC 2.7.13.3) kdpD b0695 JW0683 kdpD 98,718 cellular response to extracellular stimulus [GO:0031668]; cellular response to salt stress [GO:0071472]; detection of chemical stimulus [GO:0009593]; protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphatase activity [GO:0016791]; phosphorelay sensor kinase activity [GO:0000155]; transcription factor binding [GO:0008134]; cellular response to extracellular stimulus [GO:0031668]; cellular response to salt stress [GO:0071472]; detection of chemical stimulus [GO:0009593]; protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165] ATP binding [GO:0005524]; phosphatase activity [GO:0016791]; phosphorelay sensor kinase activity [GO:0000155]; transcription factor binding [GO:0008134] GO:0000155; GO:0005524; GO:0005886; GO:0005887; GO:0007165; GO:0008134; GO:0009593; GO:0016791; GO:0031668; GO:0046777; GO:0071472 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:1532388}; Multi-pass membrane protein {ECO:0000269|PubMed:1532388}. +P77154 KOJP_ECOLI Kojibiose phosphorylase (EC 2.4.1.230) ycjT b1316 JW1309 ycjT 84,867 carbohydrate metabolic process [GO:0005975] carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; kojibiose phosphorylase activity [GO:0033831]; carbohydrate metabolic process [GO:0005975] carbohydrate binding [GO:0030246]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; kojibiose phosphorylase activity [GO:0033831] GO:0004553; GO:0005975; GO:0030246; GO:0033831 +P77672 LSRC_ECOLI Autoinducer 2 import system permease protein LsrC (AI-2 import system permease protein LsrC) lsrC ydeY b1514 JW1507 ydeY lsrC 36,395 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P33231 LLDP_ECOLI L-lactate permease lldP lctP b3603 JW3578 lctP lldP 59,168 cellular response to DNA damage stimulus [GO:0006974] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; lactate transmembrane transporter activity [GO:0015129]; solute:proton symporter activity [GO:0015295]; cellular response to DNA damage stimulus [GO:0006974] lactate transmembrane transporter activity [GO:0015129]; solute:proton symporter activity [GO:0015295] GO:0005886; GO:0005887; GO:0006974; GO:0015129; GO:0015295 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P37636 MDTE_ECOLI Multidrug resistance protein MdtE mdtE yhiU b3513 JW3481 yhiU mdtE 41,191 bile acid and bile salt transport [GO:0015721]; response to antibiotic [GO:0046677]; response to toxic substance [GO:0009636]; xenobiotic transport [GO:0042908] intrinsic component of plasma membrane [GO:0031226]; plasma membrane [GO:0005886] intrinsic component of plasma membrane [GO:0031226]; plasma membrane [GO:0005886]; bile acid transmembrane transporter activity [GO:0015125]; identical protein binding [GO:0042802]; xenobiotic transmembrane transporter activity [GO:0042910]; bile acid and bile salt transport [GO:0015721]; response to antibiotic [GO:0046677]; response to toxic substance [GO:0009636]; xenobiotic transport [GO:0042908] bile acid transmembrane transporter activity [GO:0015125]; identical protein binding [GO:0042802]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0009636; GO:0015125; GO:0015721; GO:0031226; GO:0042802; GO:0042908; GO:0042910; GO:0046677 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P03841 MALM_ECOLI Maltose operon periplasmic protein malM molA b4037 JW3997 molA malM 31,943 carbohydrate transport [GO:0008643] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; carbohydrate transport [GO:0008643] GO:0008643; GO:0030288 SUBCELLULAR LOCATION: Periplasm. +P0DSF3 MGTT_ECOLI Protein MgtT mgtT b4775 mgtT 3,858 +P0A731 MGSA_ECOLI Methylglyoxal synthase (MGS) (EC 4.2.3.3) mgsA yccG b0963 JW5129 yccG mgsA 16,919 methylglyoxal biosynthetic process [GO:0019242] cytosol [GO:0005829] cytosol [GO:0005829]; methylglyoxal synthase activity [GO:0008929]; methylglyoxal biosynthetic process [GO:0019242] methylglyoxal synthase activity [GO:0008929] GO:0005829; GO:0008929; GO:0019242 SUBCELLULAR LOCATION: Cytoplasm. +P77608 MHPD_ECOLI 2-keto-4-pentenoate hydratase (EC 4.2.1.80) (2-hydroxypentadienoic acid hydratase) mhpD b0350 JW0341 mhpD 28,890 3-phenylpropionate catabolic process [GO:0019380]; aromatic compound catabolic process [GO:0019439] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 2-oxopent-4-enoate hydratase activity [GO:0008684]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; 3-phenylpropionate catabolic process [GO:0019380]; aromatic compound catabolic process [GO:0019439] 2-oxopent-4-enoate hydratase activity [GO:0008684]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145] GO:0005737; GO:0008684; GO:0019380; GO:0019439; GO:0030145; GO:0042802 +P76342 MSRP_ECOLI Protein-methionine-sulfoxide reductase catalytic subunit MsrP (EC 1.8.5.-) msrP yedY b1971 JW1954 yedY msrP 37,369 protein repair [GO:0030091]; response to hypochlorite [GO:1901530]; response to oxidative stress [GO:0006979] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; metal ion binding [GO:0046872]; molybdopterin cofactor binding [GO:0043546]; oxidoreductase activity, acting on a heme group of donors [GO:0016675]; oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor [GO:0016672]; protein repair [GO:0030091]; response to hypochlorite [GO:1901530]; response to oxidative stress [GO:0006979] metal ion binding [GO:0046872]; molybdopterin cofactor binding [GO:0043546]; oxidoreductase activity, acting on a heme group of donors [GO:0016675]; oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor [GO:0016672] GO:0006979; GO:0016672; GO:0016675; GO:0030091; GO:0030288; GO:0043546; GO:0046872; GO:1901530 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:16042411}. Note=Is attached to the inner membrane when interacting with the MsrQ subunit. +P32712 NRFG_ECOLI Formate-dependent nitrite reductase complex subunit NrfG nrfG yjcN b4076 JW4037 yjcN nrfG 22,784 cytochrome c-heme linkage via heme-L-cysteine [GO:0018378] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; cytochrome c-heme linkage via heme-L-cysteine [GO:0018378] GO:0005886; GO:0018378 +P0AES0 GSP_ECOLI Bifunctional glutathionylspermidine synthetase/amidase (GspSA) [Includes: Glutathionylspermidine amidase (Gsp amidase) (EC 3.5.1.78) (Glutathionylspermidine amidohydrolase [spermidine-forming]); Glutathionylspermidine synthetase (Gsp synthetase) (EC 6.3.1.8) (Glutathione:spermidine ligase [ADP-forming]) (Gsp synthase)] gss gsp b2988 JW2956 gsp gss 70,532 glutathione metabolic process [GO:0006749]; spermidine metabolic process [GO:0008216] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; glutathionylspermidine amidase activity [GO:0008884]; glutathionylspermidine synthase activity [GO:0008885]; ligase activity [GO:0016874]; metal ion binding [GO:0046872]; glutathione metabolic process [GO:0006749]; spermidine metabolic process [GO:0008216] ATP binding [GO:0005524]; glutathionylspermidine amidase activity [GO:0008884]; glutathionylspermidine synthase activity [GO:0008885]; ligase activity [GO:0016874]; metal ion binding [GO:0046872] GO:0005524; GO:0005829; GO:0006749; GO:0008216; GO:0008884; GO:0008885; GO:0016874; GO:0046872 +P45759 GSPE_ECOLI Putative type II secretion system protein E (T2SS protein E) (EC 7.4.2.8) (Putative general secretion pathway protein E) (Type II traffic warden ATPase) gspE yheG b3326 JW3288 yheG gspE 54,611 protein secretion by the type II secretion system [GO:0015628] plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627] plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein secretion by the type II secretion system [GO:0015628] ATP binding [GO:0005524]; metal ion binding [GO:0046872] GO:0005524; GO:0005886; GO:0015627; GO:0015628; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250|UniProtKB:Q00512}. Note=Membrane association is not an intrinsic property but requires the GspL gene product. {ECO:0000250|UniProtKB:Q00512}. +P75824 HCR_ECOLI NADH oxidoreductase HCR (EC 1.-.-.-) hcr ybjV b0872 JW5117 ybjV hcr 35,740 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on NAD(P)H [GO:0016651] 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on NAD(P)H [GO:0016651] GO:0009055; GO:0016651; GO:0046872; GO:0050660; GO:0051537 +P09127 HEMX_ECOLI Protein HemX (ORF X) hemX b3803 JW3775 hemX 42,963 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137}; Single-pass membrane protein {ECO:0000255}. +P06987 HIS7_ECOLI Histidine biosynthesis bifunctional protein HisB [Includes: Histidinol-phosphatase (EC 3.1.3.15); Imidazoleglycerol-phosphate dehydratase (IGPD) (EC 4.2.1.19)] hisB b2022 JW2004 hisB 40,278 histidine biosynthetic process [GO:0000105] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; histidinol-phosphatase activity [GO:0004401]; identical protein binding [GO:0042802]; imidazoleglycerol-phosphate dehydratase activity [GO:0004424]; metal ion binding [GO:0046872]; histidine biosynthetic process [GO:0000105] histidinol-phosphatase activity [GO:0004401]; identical protein binding [GO:0042802]; imidazoleglycerol-phosphate dehydratase activity [GO:0004424]; metal ion binding [GO:0046872] GO:0000105; GO:0004401; GO:0004424; GO:0005737; GO:0042802; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01022}. +P77319 HSCC_ECOLI Chaperone protein HscC (Hsc62) hscC ybeW b0650 JW0645 ybeW hscC 61,986 cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; ATPase activity [GO:0016887] ATPase activity [GO:0016887]; ATP binding [GO:0005524] GO:0005524; GO:0005829; GO:0016887 +P0ABS8 HOLE_ECOLI DNA polymerase III subunit theta (EC 2.7.7.7) holE b1842 JW1831 holE 8,846 DNA replication [GO:0006260] cytosol [GO:0005829]; DNA polymerase III, core complex [GO:0044776] cytosol [GO:0005829]; DNA polymerase III, core complex [GO:0044776]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; DNA replication [GO:0006260] DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887] GO:0003677; GO:0003887; GO:0005829; GO:0006260; GO:0044776 +P0AD57 ISPB_ECOLI Octaprenyl diphosphate synthase (EC 2.5.1.90) (All-trans-octaprenyl-diphosphate synthase) (Octaprenyl pyrophosphate synthase) (OPP synthase) ispB cel yhbD b3187 JW3154 cel yhbD ispB 35,217 isoprenoid biosynthetic process [GO:0008299]; polyprenol biosynthetic process [GO:0016094]; ubiquinone biosynthetic process [GO:0006744] cytosol [GO:0005829] cytosol [GO:0005829]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; octaprenyl pyrophosphate synthase activity [GO:0106350]; prenyltransferase activity [GO:0004659]; isoprenoid biosynthetic process [GO:0008299]; polyprenol biosynthetic process [GO:0016094]; ubiquinone biosynthetic process [GO:0006744] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; octaprenyl pyrophosphate synthase activity [GO:0106350]; prenyltransferase activity [GO:0004659] GO:0004659; GO:0005829; GO:0006744; GO:0008299; GO:0016094; GO:0042802; GO:0046872; GO:0106350 +P37326 INTS_ECOLI Prophage integrase IntS (Putative prophage CPS-53 integrase) intS intC yfdB b2349 JW2345 intC yfdB intS 44,061 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; provirus excision [GO:0032359]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; provirus excision [GO:0032359]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] identical protein binding [GO:0042802]; sequence-specific DNA binding [GO:0043565] GO:0006310; GO:0015074; GO:0032359; GO:0042802; GO:0043565; GO:0044826; GO:0046718; GO:0075713 +P0CF56 INSD4_ECOLI Transposase InsD for insertion element IS2H insD4 b2860 JW2826 insD4 34,398 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0032196 +P0CF12 INSA6_ECOLI Insertion element IS1 6 protein InsA (IS1e) insA6 b3444 JW3408 insA6 9,868 transposition, DNA-mediated [GO:0006313] transposition, DNA-mediated [GO:0006313] GO:0006313 +P0CF80 INSF2_ECOLI Transposase InsF for insertion sequence IS3B insF2 b0372 JW0363 insF2 33,540 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0032196 +P0CF81 INSF3_ECOLI Transposase InsF for insertion sequence IS3C insF3 b0541 JW0529 insF3 33,540 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition [GO:0032196] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0032196 +P0CE55 INSH8_ECOLI Transposase InsH for insertion sequence element IS5K insH8 b2192 JW2179 insH8 37,851 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CE56 INSH9_ECOLI Transposase InsH for insertion sequence element IS5LO insH9 b2982 JW2949 insH9 37,851 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P19768 INSJ_ECOLI Insertion element IS150 protein InsJ (ORFA) insJ b3557 JW3527 insJ 19,725 sequence-specific DNA binding [GO:0043565] sequence-specific DNA binding [GO:0043565] GO:0043565 +P0AEX5 KPPR_ECOLI Probable phosphoribulokinase (PRK) (PRKase) (EC 2.7.1.19) (Phosphopentokinase) prkB yhfF b3355 JW3318 yhfF prkB 32,344 carbohydrate metabolic process [GO:0005975] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; phosphoribulokinase activity [GO:0008974]; carbohydrate metabolic process [GO:0005975] ATP binding [GO:0005524]; phosphoribulokinase activity [GO:0008974] GO:0005524; GO:0005737; GO:0005975; GO:0008974 +P40874 MTOX_ECOLI N-methyl-L-tryptophan oxidase (MTOX) (EC 1.5.3.-) solA b1059 JW1046 solA 40,902 cellular response to DNA damage stimulus [GO:0006974] cytosol [GO:0005829] cytosol [GO:0005829]; flavin adenine dinucleotide binding [GO:0050660]; N-methyl-L-amino-acid oxidase activity [GO:0050131]; sarcosine oxidase activity [GO:0008115]; cellular response to DNA damage stimulus [GO:0006974] flavin adenine dinucleotide binding [GO:0050660]; N-methyl-L-amino-acid oxidase activity [GO:0050131]; sarcosine oxidase activity [GO:0008115] GO:0005829; GO:0006974; GO:0008115; GO:0050131; GO:0050660 +P52647 NIFJ_ECOLI Probable pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) ydbK b1378 JW1372 ydbK 128,824 electron transport chain [GO:0022900]; response to oxidative stress [GO:0006979] 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; pyruvate-flavodoxin oxidoreductase activity [GO:0043873]; thiamine pyrophosphate binding [GO:0030976]; electron transport chain [GO:0022900]; response to oxidative stress [GO:0006979] 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; pyruvate-flavodoxin oxidoreductase activity [GO:0043873]; thiamine pyrophosphate binding [GO:0030976] GO:0005506; GO:0006979; GO:0022900; GO:0030976; GO:0043873; GO:0051539 +P0AFA7 NHAB_ECOLI Na(+)/H(+) antiporter NhaB (Sodium/proton antiporter NhaB) nhaB b1186 JW1175 nhaB 56,728 intracellular pH reduction [GO:0051452]; proton transmembrane transport [GO:1902600]; response to lithium ion [GO:0010226]; sodium ion transport [GO:0006814] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cation:cation antiporter activity [GO:0015491]; sodium:proton antiporter activity [GO:0015385]; intracellular pH reduction [GO:0051452]; proton transmembrane transport [GO:1902600]; response to lithium ion [GO:0010226]; sodium ion transport [GO:0006814] cation:cation antiporter activity [GO:0015491]; sodium:proton antiporter activity [GO:0015385] GO:0005886; GO:0005887; GO:0006814; GO:0010226; GO:0015385; GO:0015491; GO:0016021; GO:0051452; GO:1902600 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0ABU5 ELBB_ECOLI Glyoxalase ElbB (EC 4.2.1.-) (Sigma cross-reacting protein 27A) (SCRP-27A) elbB elb2 yzzB b3209 JW3176 elb2 yzzB elbB 22,982 isoprenoid biosynthetic process [GO:0008299]; positive regulation of isoprenoid metabolic process [GO:0045828] cytosol [GO:0005829] cytosol [GO:0005829]; lyase activity [GO:0016829]; isoprenoid biosynthetic process [GO:0008299]; positive regulation of isoprenoid metabolic process [GO:0045828] lyase activity [GO:0016829] GO:0005829; GO:0008299; GO:0016829; GO:0045828 +P65643 EUTT_ECOLI EutT adenosyltransferase (ATP:co(I)rrinoid adenosyltransferase) (ACAT) (Cob(II)alamin adenosyltransferase EutT) (Ethanolamine utilization cobalamin adenosyltransferase) (Ethanolamine utilization corrinoid adenosyltransferase) eutT ypfB b2459 JW2443 ypfB eutT 30,172 cobalamin biosynthetic process [GO:0009236]; ethanolamine catabolic process [GO:0046336] ATP binding [GO:0005524]; cob(I)yrinic acid a,c-diamide adenosyltransferase activity [GO:0008817]; cobalamin biosynthetic process [GO:0009236]; ethanolamine catabolic process [GO:0046336] ATP binding [GO:0005524]; cob(I)yrinic acid a,c-diamide adenosyltransferase activity [GO:0008817] GO:0005524; GO:0008817; GO:0009236; GO:0046336 SUBCELLULAR LOCATION: Bacterial microcompartment {ECO:0000305}. +P0AEK0 EXOX_ECOLI Exodeoxyribonuclease 10 (EC 3.1.11.-) (Exodeoxyribonuclease X) (Exo X) (Exonuclease X) exoX yobC b1844 JW1833 yobC exoX 25,133 DNA replication proofreading [GO:0045004]; mismatch repair [GO:0006298] cytosol [GO:0005829] cytosol [GO:0005829]; 3'-5' exonuclease activity [GO:0008408]; nucleic acid binding [GO:0003676]; DNA replication proofreading [GO:0045004]; mismatch repair [GO:0006298] 3'-5' exonuclease activity [GO:0008408]; nucleic acid binding [GO:0003676] GO:0003676; GO:0005829; GO:0006298; GO:0008408; GO:0045004 +P38135 FADK_ECOLI Medium-chain fatty-acid--CoA ligase (EC 6.2.1.-) (Acyl-CoA synthetase) (ACS) (Fatty acyl-CoA synthetase FadK) fadK ydiD b1701 JW5910 ydiD fadK 62,759 fatty acid beta-oxidation [GO:0006635] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; medium-chain fatty acid-CoA ligase activity [GO:0031956]; fatty acid beta-oxidation [GO:0006635] ATP binding [GO:0005524]; medium-chain fatty acid-CoA ligase activity [GO:0031956] GO:0005524; GO:0005886; GO:0006635; GO:0031956 SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Note=Partially membrane-associated. {ECO:0000305|PubMed:15213221}. +P0ACK8 FUCR_ECOLI L-fucose operon activator fucR b2805 JW2776 fucR 27,362 fucose metabolic process [GO:0006004]; regulation of fucose catabolic process [GO:0043468] DNA binding [GO:0003677]; ligand-activated transcription factor activity [GO:0098531]; fucose metabolic process [GO:0006004]; regulation of fucose catabolic process [GO:0043468] DNA binding [GO:0003677]; ligand-activated transcription factor activity [GO:0098531] GO:0003677; GO:0006004; GO:0043468; GO:0098531 +P25527 GABP_ECOLI GABA permease (4-amino butyrate transport carrier) (Gamma-aminobutyrate permease) gabP b2663 JW2638 gabP 51,080 cellular response to DNA damage stimulus [GO:0006974]; cellular response to nitrogen starvation [GO:0006995]; gamma-aminobutyric acid catabolic process [GO:0009450]; gamma-aminobutyric acid transport [GO:0015812]; response to carbon starvation [GO:0090549] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; secondary active transmembrane transporter activity [GO:0015291]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to nitrogen starvation [GO:0006995]; gamma-aminobutyric acid catabolic process [GO:0009450]; gamma-aminobutyric acid transport [GO:0015812]; response to carbon starvation [GO:0090549] gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; secondary active transmembrane transporter activity [GO:0015291] GO:0005886; GO:0006974; GO:0006995; GO:0009450; GO:0015185; GO:0015291; GO:0015812; GO:0016021; GO:0090549 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P37639 GADX_ECOLI HTH-type transcriptional regulator GadX gadX yhiX b3516 JW3484 yhiX gadX 31,563 cellular response to DNA damage stimulus [GO:0006974]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; cellular response to DNA damage stimulus [GO:0006974]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription activator activity [GO:0001216]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0000986; GO:0001216; GO:0003700; GO:0006351; GO:0006974; GO:0045893 +P0A8Q3 FRDD_ECOLI Fumarate reductase subunit D (Fumarate reductase 13 kDa hydrophobic protein) (Quinol-fumarate reductase subunit D) (QFR subunit D) frdD b4151 JW4112 frdD 13,107 anaerobic respiration [GO:0009061]; bacterial-type flagellum assembly [GO:0044780]; fermentation [GO:0006113]; fumarate metabolic process [GO:0006106] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; plasma membrane fumarate reductase complex [GO:0045284] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; plasma membrane fumarate reductase complex [GO:0045284]; fumarate reductase (menaquinone) [GO:0102040]; succinate dehydrogenase activity [GO:0000104]; anaerobic respiration [GO:0009061]; bacterial-type flagellum assembly [GO:0044780]; fermentation [GO:0006113]; fumarate metabolic process [GO:0006106] fumarate reductase (menaquinone) [GO:0102040]; succinate dehydrogenase activity [GO:0000104] GO:0000104; GO:0005886; GO:0005887; GO:0006106; GO:0006113; GO:0009061; GO:0044780; GO:0045284; GO:0102040 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00709, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00709, ECO:0000269|PubMed:10373108}. +P31120 GLMM_ECOLI Phosphoglucosamine mutase (EC 5.4.2.10) glmM mrsA yhbF b3176 JW3143 mrsA yhbF glmM 47,544 carbohydrate metabolic process [GO:0005975]; peptidoglycan biosynthetic process [GO:0009252]; protein autophosphorylation [GO:0046777]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] cytosol [GO:0005829] cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; phosphoglucosamine mutase activity [GO:0008966]; phosphomannomutase activity [GO:0004615]; carbohydrate metabolic process [GO:0005975]; peptidoglycan biosynthetic process [GO:0009252]; protein autophosphorylation [GO:0046777]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] magnesium ion binding [GO:0000287]; phosphoglucosamine mutase activity [GO:0008966]; phosphomannomutase activity [GO:0004615] GO:0000287; GO:0004615; GO:0005829; GO:0005975; GO:0006048; GO:0008966; GO:0009252; GO:0046777 +P75797 GSIB_ECOLI Glutathione-binding protein GsiB gsiB yliB b0830 JW5111 yliB gsiB 56,470 cellular response to DNA damage stimulus [GO:0006974]; dipeptide transport [GO:0042938]; peptide transport [GO:0015833] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288]; peptide transmembrane transporter activity [GO:1904680]; cellular response to DNA damage stimulus [GO:0006974]; dipeptide transport [GO:0042938]; peptide transport [GO:0015833] peptide transmembrane transporter activity [GO:1904680] GO:0006974; GO:0015833; GO:0030288; GO:0042938; GO:0043190; GO:1904680 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P75793 GRE2_ECOLI Probable dehydratase YbiW (EC 4.2.1.-) ybiW b0823 JW0807 ybiW 90,125 cytosol [GO:0005829] cytosol [GO:0005829]; lyase activity [GO:0016829] lyase activity [GO:0016829] GO:0005829; GO:0016829 +P0AES4 GYRA_ECOLI DNA gyrase subunit A (EC 5.6.2.2) gyrA hisW nalA parD b2231 JW2225 hisW nalA parD gyrA 96,964 DNA-dependent DNA replication [GO:0006261]; DNA topological change [GO:0006265]; response to antibiotic [GO:0046677]; response to drug [GO:0042493]; transcription, DNA-templated [GO:0006351] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex [GO:0009330]; membrane [GO:0016020] chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex [GO:0009330]; membrane [GO:0016020]; ATP binding [GO:0005524]; ATPase activity, acting on DNA [GO:0008094]; DNA binding [GO:0003677]; DNA negative supercoiling activity [GO:0034335]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; identical protein binding [GO:0042802]; DNA topological change [GO:0006265]; DNA-dependent DNA replication [GO:0006261]; response to antibiotic [GO:0046677]; response to drug [GO:0042493]; transcription, DNA-templated [GO:0006351] ATPase activity, acting on DNA [GO:0008094]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA negative supercoiling activity [GO:0034335]; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO:0003918]; identical protein binding [GO:0042802] GO:0003677; GO:0003918; GO:0005524; GO:0005694; GO:0005737; GO:0005829; GO:0006261; GO:0006265; GO:0006351; GO:0008094; GO:0009330; GO:0016020; GO:0034335; GO:0042493; GO:0042802; GO:0046677 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01897}. +P06983 HEM3_ECOLI Porphobilinogen deaminase (PBG) (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) hemC popE b3805 JW5932 popE hemC 33,852 heme biosynthetic process [GO:0006783]; peptidyl-pyrromethane cofactor linkage [GO:0018160]; protoporphyrinogen IX biosynthetic process [GO:0006782]; tetrapyrrole biosynthetic process [GO:0033014] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; hydroxymethylbilane synthase activity [GO:0004418]; heme biosynthetic process [GO:0006783]; peptidyl-pyrromethane cofactor linkage [GO:0018160]; protoporphyrinogen IX biosynthetic process [GO:0006782]; tetrapyrrole biosynthetic process [GO:0033014] hydroxymethylbilane synthase activity [GO:0004418] GO:0004418; GO:0005737; GO:0005829; GO:0006782; GO:0006783; GO:0018160; GO:0033014 +P0AEU0 HISJ_ECOLI Histidine-binding periplasmic protein (HBP) hisJ b2309 JW2306 hisJ 28,483 amino acid transport [GO:0006865] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; amino acid binding [GO:0016597]; amino acid transport [GO:0006865] amino acid binding [GO:0016597] GO:0006865; GO:0016597; GO:0030288 SUBCELLULAR LOCATION: Periplasm. +P0A6Z3 HTPG_ECOLI Chaperone protein HtpG (Heat shock protein C62.5) (Heat shock protein HtpG) (High temperature protein G) htpG b0473 JW0462 htpG 71,423 ATP-dependent chaperone mediated protein folding [GO:0061992]; cellular response to DNA damage stimulus [GO:0006974]; FtsZ-dependent cytokinesis [GO:0043093]; protein folding [GO:0006457]; response to heat [GO:0009408] cytosol [GO:0005829]; plasma membrane [GO:0005886] cytosol [GO:0005829]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; chaperone binding [GO:0051087]; identical protein binding [GO:0042802]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082]; ATP-dependent chaperone mediated protein folding [GO:0061992]; cellular response to DNA damage stimulus [GO:0006974]; FtsZ-dependent cytokinesis [GO:0043093]; protein folding [GO:0006457]; response to heat [GO:0009408] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; chaperone binding [GO:0051087]; identical protein binding [GO:0042802]; protein folding chaperone [GO:0044183]; unfolded protein binding [GO:0051082] GO:0005524; GO:0005829; GO:0005886; GO:0006457; GO:0006974; GO:0009408; GO:0016887; GO:0042802; GO:0043093; GO:0044183; GO:0051082; GO:0051087; GO:0061992 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16079137}. Cell inner membrane {ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000269|PubMed:16079137}. +P36645 HOFB_ECOLI Protein transport protein HofB homolog hofB hopB b0107 JW0103 hopB hofB 50,615 ATP binding [GO:0005524] ATP binding [GO:0005524] GO:0005524 +P76168 INTQ_ECOLI Putative defective protein IntQ (Putative lambdoid prophage Qin defective integrase) intQ b1579 JW1571 intQ 45,262 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA binding [GO:0003677]; DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral genome integration into host DNA [GO:0044826] DNA binding [GO:0003677] GO:0003677; GO:0006310; GO:0015074; GO:0044826; GO:0046718; GO:0075713 +P0CF10 INSA4_ECOLI Insertion element IS1 4 protein InsA (IS1d) insA4 b4516 JW0971 insA4 9,902 transposition, DNA-mediated [GO:0006313] transposition, DNA-mediated [GO:0006313] GO:0006313 +P0CF11 INSA5_ECOLI Insertion element IS1 5 protein InsA (IS1h) insA5 b1894 insA5 9,868 transposition, DNA-mediated [GO:0006313] transposition, DNA-mediated [GO:0006313] GO:0006313 +P0CF88 INSI1_ECOLI Transposase InsI for insertion sequence element IS30A insI1 b0256 JW0246 insI1 44,267 DNA integration [GO:0015074]; transposition [GO:0032196]; transposition, DNA-mediated [GO:0006313] protein-DNA complex [GO:0032993] protein-DNA complex [GO:0032993]; DNA insertion or deletion binding [GO:0032135]; sequence-specific DNA binding [GO:0043565]; transposase activity [GO:0004803]; DNA integration [GO:0015074]; transposition [GO:0032196]; transposition, DNA-mediated [GO:0006313] DNA insertion or deletion binding [GO:0032135]; sequence-specific DNA binding [GO:0043565]; transposase activity [GO:0004803] GO:0004803; GO:0006313; GO:0015074; GO:0032135; GO:0032196; GO:0032993; GO:0043565 +P0CF70 INSE5_ECOLI Transposase InsE for insertion sequence IS3E insE5 b2088 JW5341 insE5 11,543 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P0CF90 INSI4_ECOLI Transposase InsI for insertion sequence element IS30D insI4 b4284 JW4244 insI4 44,281 DNA integration [GO:0015074]; transposition [GO:0032196]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; DNA integration [GO:0015074]; transposition [GO:0032196]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313; GO:0015074; GO:0032196 +P0ADG7 IMDH_ECOLI Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC 1.1.1.205) guaB guaR b2508 JW5401 guaR guaB 52,022 GMP biosynthetic process [GO:0006177]; GTP biosynthetic process [GO:0006183]; protein homotetramerization [GO:0051289]; response to UV [GO:0009411] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; C-rich single-stranded DNA binding [GO:1990829]; identical protein binding [GO:0042802]; IMP dehydrogenase activity [GO:0003938]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]; GMP biosynthetic process [GO:0006177]; GTP biosynthetic process [GO:0006183]; protein homotetramerization [GO:0051289]; response to UV [GO:0009411] ATP binding [GO:0005524]; C-rich single-stranded DNA binding [GO:1990829]; identical protein binding [GO:0042802]; IMP dehydrogenase activity [GO:0003938]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697] GO:0003697; GO:0003938; GO:0005524; GO:0005829; GO:0006177; GO:0006183; GO:0009411; GO:0042802; GO:0046872; GO:0051289; GO:1990829 +P30126 LEUD_ECOLI 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase) leuD b0071 JW0070 leuD 22,487 branched-chain amino acid biosynthetic process [GO:0009082]; leucine biosynthetic process [GO:0009098] 3-isopropylmalate dehydratase complex [GO:0009316]; cytosol [GO:0005829] 3-isopropylmalate dehydratase complex [GO:0009316]; cytosol [GO:0005829]; 3-isopropylmalate dehydratase activity [GO:0003861]; branched-chain amino acid biosynthetic process [GO:0009082]; leucine biosynthetic process [GO:0009098] 3-isopropylmalate dehydratase activity [GO:0003861] GO:0003861; GO:0005829; GO:0009082; GO:0009098; GO:0009316 +P76399 MDTC_ECOLI Multidrug resistance protein MdtC (Multidrug transporter MdtC) mdtC yegO b2076 JW2061 yegO mdtC 111,010 bile acid and bile salt transport [GO:0015721]; proton transmembrane transport [GO:1902600]; xenobiotic transport [GO:0042908] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; bile acid transmembrane transporter activity [GO:0015125]; xenobiotic transmembrane transporter activity [GO:0042910]; bile acid and bile salt transport [GO:0015721]; proton transmembrane transport [GO:1902600]; xenobiotic transport [GO:0042908] bile acid transmembrane transporter activity [GO:0015125]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0005887; GO:0015125; GO:0015721; GO:0042908; GO:0042910; GO:1902600 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P78285 LYSD_ECOLI Lysozyme RrrD (EC 3.2.1.17) (Endolysin) (Lysis protein) (Muramidase) rrrD arrD ybcS b0555 JW0544 arrD ybcS rrrD 17,972 cell wall macromolecule catabolic process [GO:0016998]; cytolysis [GO:0019835]; defense response to bacterium [GO:0042742]; peptidoglycan catabolic process [GO:0009253]; viral release from host cell by cytolysis [GO:0044659] lysozyme activity [GO:0003796]; cell wall macromolecule catabolic process [GO:0016998]; cytolysis [GO:0019835]; defense response to bacterium [GO:0042742]; peptidoglycan catabolic process [GO:0009253]; viral release from host cell by cytolysis [GO:0044659] lysozyme activity [GO:0003796] GO:0003796; GO:0009253; GO:0016998; GO:0019835; GO:0042742; GO:0044659 +P0A908 MIPA_ECOLI MltA-interacting protein mipA yeaF b1782 JW1771 yeaF mipA 27,831 peptidoglycan biosynthetic process [GO:0009252] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; protein-macromolecule adaptor activity [GO:0030674]; peptidoglycan biosynthetic process [GO:0009252] protein-macromolecule adaptor activity [GO:0030674] GO:0009252; GO:0009279; GO:0030674 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:16079137}. +P76096 MOKB_ECOLI Regulatory protein MokB mokB b1420 JW5882 mokB 5,894 +P33607 NUOL_ECOLI NADH-quinone oxidoreductase subunit L (EC 7.1.1.-) (NADH dehydrogenase I subunit L) (NDH-1 subunit L) (NUO12) nuoL b2278 JW2273 nuoL 66,438 ATP synthesis coupled electron transport [GO:0042773]; electron transport coupled proton transport [GO:0015990] integral component of plasma membrane [GO:0005887]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272] integral component of plasma membrane [GO:0005887]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038]; ATP synthesis coupled electron transport [GO:0042773]; electron transport coupled proton transport [GO:0015990] NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] GO:0005886; GO:0005887; GO:0008137; GO:0015990; GO:0030964; GO:0042773; GO:0045272; GO:0048038 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P23849 TRKG_ECOLI Trk system potassium uptake protein TrkG trkG b1363 JW1358 trkG 53,944 potassium ion transmembrane transport [GO:0071805] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; potassium channel activity [GO:0005267]; potassium ion binding [GO:0030955]; potassium ion transmembrane transporter activity [GO:0015079]; potassium:chloride symporter activity [GO:0015379]; potassium ion transmembrane transport [GO:0071805] potassium:chloride symporter activity [GO:0015379]; potassium channel activity [GO:0005267]; potassium ion binding [GO:0030955]; potassium ion transmembrane transporter activity [GO:0015079] GO:0005267; GO:0005886; GO:0005887; GO:0015079; GO:0015379; GO:0030955; GO:0071805 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2022616}; Multi-pass membrane protein {ECO:0000269|PubMed:2022616}. +P00895 TRPE_ECOLI Anthranilate synthase component 1 (AS) (ASI) (EC 4.1.3.27) trpE b1264 JW1256 trpE 57,494 tryptophan biosynthetic process [GO:0000162] cytosol [GO:0005829] cytosol [GO:0005829]; anthranilate synthase activity [GO:0004049]; metal ion binding [GO:0046872]; tryptophan biosynthetic process [GO:0000162] anthranilate synthase activity [GO:0004049]; metal ion binding [GO:0046872] GO:0000162; GO:0004049; GO:0005829; GO:0046872 +P0A879 TRPB_ECOLI Tryptophan synthase beta chain (EC 4.2.1.20) trpB b1261 JW1253 trpB 42,983 aromatic amino acid family biosynthetic process [GO:0009073]; tryptophan biosynthetic process [GO:0000162] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; tryptophan synthase activity [GO:0004834]; aromatic amino acid family biosynthetic process [GO:0009073]; tryptophan biosynthetic process [GO:0000162] identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; tryptophan synthase activity [GO:0004834] GO:0000162; GO:0004834; GO:0005737; GO:0005829; GO:0009073; GO:0030170; GO:0042802 +P39301 ULAA_ECOLI Ascorbate-specific PTS system EIIC component (Ascorbate-specific permease IIC component UlaA) ulaA sgaT yjfS b4193 JW5744 sgaT yjfS ulaA 50,737 L-ascorbic acid transmembrane transport [GO:0015882]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity [GO:0090585]; L-ascorbic acid transmembrane transport [GO:0015882]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] identical protein binding [GO:0042802]; protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity [GO:0090585] GO:0005886; GO:0009401; GO:0015882; GO:0016020; GO:0016021; GO:0042802; GO:0090585 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0AED0 USPA_ECOLI Universal stress protein A uspA b3495 JW3462 uspA 16,066 cytoplasm [GO:0005737]; membrane [GO:0016020] cytoplasm [GO:0005737]; membrane [GO:0016020]; identical protein binding [GO:0042802] identical protein binding [GO:0042802] GO:0005737; GO:0016020; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm. +P09836 UHPC_ECOLI Membrane sensor protein UhpC uhpC b3667 JW3642 uhpC 48,257 phosphorelay signal transduction system [GO:0000160] integral component of plasma membrane [GO:0005887]; intrinsic component of plasma membrane [GO:0031226]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; intrinsic component of plasma membrane [GO:0031226]; membrane [GO:0016020]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; phosphorelay signal transduction system [GO:0000160] transmembrane transporter activity [GO:0022857] GO:0000160; GO:0005886; GO:0005887; GO:0016020; GO:0022857; GO:0031226 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P37751 WBBK_ECOLI Putative glycosyltransferase WbbK wbbK yefI b2032 JW2017 yefI wbbK 43,188 lipopolysaccharide biosynthetic process [GO:0009103] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; transferase activity, transferring glycosyl groups [GO:0016757]; lipopolysaccharide biosynthetic process [GO:0009103] transferase activity, transferring glycosyl groups [GO:0016757] GO:0005886; GO:0009103; GO:0016757 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P0AGA6 UHPA_ECOLI Transcriptional regulatory protein UhpA uhpA b3669 JW3644 uhpA 20,889 phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677] GO:0000160; GO:0003677; GO:0005737; GO:0006355 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AED5 UVRY_ECOLI Response regulator UvrY uvrY yecB b1914 JW1899 yecB uvrY 23,893 phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; phosphorelay response regulator activity [GO:0000156]; phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; phosphorelay response regulator activity [GO:0000156] GO:0000156; GO:0000160; GO:0003677; GO:0005737; GO:0006355 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AAC0 USPE_ECOLI Universal stress protein E uspE ydaA b1333 JW1327 ydaA uspE 35,707 bacterial-type flagellum-dependent cell motility [GO:0071973]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to UV [GO:0034644]; single-species biofilm formation [GO:0044010] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; bacterial-type flagellum-dependent cell motility [GO:0071973]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to UV [GO:0034644]; single-species biofilm formation [GO:0044010] GO:0005737; GO:0034644; GO:0044010; GO:0070301; GO:0071973 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P0AGC0 UHPT_ECOLI Hexose-6-phosphate:phosphate antiporter uhpT b3666 JW3641 uhpT 50,607 carbohydrate transport [GO:0008643]; glucose-6-phosphate transport [GO:0015760]; hexose phosphate transport [GO:0015712] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; hexose-phosphate:inorganic phosphate antiporter activity [GO:0015526]; carbohydrate transport [GO:0008643]; glucose-6-phosphate transport [GO:0015760]; hexose phosphate transport [GO:0015712] hexose-phosphate:inorganic phosphate antiporter activity [GO:0015526] GO:0005886; GO:0008643; GO:0015526; GO:0015712; GO:0015760; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2156798, ECO:0000269|PubMed:8402899}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:2156798}. +Q46868 UBIK_ECOLI Ubiquinone biosynthesis accessory factor UbiK ubiK yqiC b3042 JW5505 yqiC ubiK 11,276 ubiquinone biosynthetic process [GO:0006744] cytosol [GO:0005829]; membrane [GO:0016020]; ubiquinone biosynthesis complex [GO:0110142] cytosol [GO:0005829]; membrane [GO:0016020]; ubiquinone biosynthesis complex [GO:0110142]; identical protein binding [GO:0042802]; ubiquinone biosynthetic process [GO:0006744] identical protein binding [GO:0042802] GO:0005829; GO:0006744; GO:0016020; GO:0042802; GO:0110142 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02216, ECO:0000269|PubMed:30686758}. +P0AAB8 USPD_ECOLI Universal stress protein D uspD yiiT b3923 JW3894 yiiT uspD 16,293 response to starvation [GO:0042594]; response to superoxide [GO:0000303]; response to UV [GO:0009411] cytosol [GO:0005829] cytosol [GO:0005829]; response to starvation [GO:0042594]; response to superoxide [GO:0000303]; response to UV [GO:0009411] GO:0000303; GO:0005829; GO:0009411; GO:0042594 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P0AG80 UGPB_ECOLI sn-glycerol-3-phosphate-binding periplasmic protein UgpB ugpB b3453 JW3418 ugpB 48,449 glycerol-3-phosphate transmembrane transport [GO:0015794]; glycerophosphodiester transmembrane transport [GO:0001407] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; glycerol-3-phosphate transmembrane transport [GO:0015794]; glycerophosphodiester transmembrane transport [GO:0001407] GO:0001407; GO:0015794; GO:0030288 SUBCELLULAR LOCATION: Periplasm. +P0AGK1 UBIA_ECOLI 4-hydroxybenzoate octaprenyltransferase (EC 2.5.1.39) (4-HB polyprenyltransferase) (PHB octaprenyl transferase) ubiA cyr b4040 JW4000 cyr ubiA 32,512 ubiquinone biosynthetic process [GO:0006744] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; 4-hydroxybenzoate decaprenyltransferase activity [GO:0002083]; 4-hydroxybenzoate nonaprenyltransferase activity [GO:0047293]; 4-hydroxybenzoate octaprenyltransferase activity [GO:0008412]; transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765]; ubiquinone biosynthetic process [GO:0006744] 4-hydroxybenzoate decaprenyltransferase activity [GO:0002083]; 4-hydroxybenzoate nonaprenyltransferase activity [GO:0047293]; 4-hydroxybenzoate octaprenyltransferase activity [GO:0008412]; transferase activity, transferring alkyl or aryl (other than methyl) groups [GO:0016765] GO:0002083; GO:0005886; GO:0006744; GO:0008412; GO:0016021; GO:0016765; GO:0047293 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01635, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:4552989, ECO:0000269|PubMed:8155731}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01635}. +P0A927 TSX_ECOLI Nucleoside-specific channel-forming protein Tsx tsx nupA b0411 JW0401 nupA tsx 33,589 nucleoside transport [GO:0015858]; viral entry into host cell [GO:0046718] cell outer membrane [GO:0009279]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; pore complex [GO:0046930]; nucleoside-specific channel forming porin activity [GO:0015471]; nucleoside transport [GO:0015858]; viral entry into host cell [GO:0046718] nucleoside-specific channel forming porin activity [GO:0015471] GO:0009279; GO:0015471; GO:0015858; GO:0046718; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:3276691, ECO:0000269|PubMed:791677}; Multi-pass membrane protein {ECO:0000305|PubMed:2458926, ECO:0000305|PubMed:3276691}. +P39305 ULAE_ECOLI L-ribulose-5-phosphate 3-epimerase UlaE (EC 5.1.3.22) (L-ascorbate utilization protein E) (L-xylulose-5-phosphate 3-epimerase) ulaE sgaU yjfW b4197 JW4155 sgaU yjfW ulaE 32,007 L-ascorbic acid catabolic process [GO:0019854]; L-ascorbic acid metabolic process [GO:0019852] intramolecular oxidoreductase activity, interconverting aldoses and ketoses [GO:0016861]; L-ribulose-5-phosphate 3-epimerase activity [GO:0034015]; L-ascorbic acid catabolic process [GO:0019854]; L-ascorbic acid metabolic process [GO:0019852] intramolecular oxidoreductase activity, interconverting aldoses and ketoses [GO:0016861]; L-ribulose-5-phosphate 3-epimerase activity [GO:0034015] GO:0016861; GO:0019852; GO:0019854; GO:0034015 +P0ADP7 UBIJ_ECOLI Ubiquinone biosynthesis accessory factor UbiJ ubiJ yigP b3834 JW3811 yigP ubiJ 22,153 ubiquinone biosynthetic process [GO:0006744]; ubiquinone biosynthetic process from chorismate [GO:0032150] cytoplasm [GO:0005737]; ubiquinone biosynthesis complex [GO:0110142] cytoplasm [GO:0005737]; ubiquinone biosynthesis complex [GO:0110142]; identical protein binding [GO:0042802]; ubiquinone biosynthetic process [GO:0006744]; ubiquinone biosynthetic process from chorismate [GO:0032150] identical protein binding [GO:0042802] GO:0005737; GO:0006744; GO:0032150; GO:0042802; GO:0110142 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02215, ECO:0000269|PubMed:30686758}. +P28634 TRMO_ECOLI tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA (m6t6A37) methyltransferase) (tRNA methyltransferase O) trmO tsaA yaeB b0195 JW0191 tsaA yaeB trmO 26,362 tRNA methylation [GO:0030488] tRNA binding [GO:0000049]; tRNA m6t6A37 methyltransferase activity [GO:0089715]; tRNA methylation [GO:0030488] tRNA binding [GO:0000049]; tRNA m6t6A37 methyltransferase activity [GO:0089715] GO:0000049; GO:0030488; GO:0089715 +P0A6L7 UXAB_ECOLI Altronate oxidoreductase (EC 1.1.1.58) (Tagaturonate dehydrogenase) (Tagaturonate reductase) uxaB b1521 JW1514 uxaB 54,808 D-galacturonate catabolic process [GO:0019698]; mannitol catabolic process [GO:0019592] cytosol [GO:0005829] cytosol [GO:0005829]; mannitol-1-phosphate 5-dehydrogenase activity [GO:0008926]; tagaturonate reductase activity [GO:0009026]; D-galacturonate catabolic process [GO:0019698]; mannitol catabolic process [GO:0019592] mannitol-1-phosphate 5-dehydrogenase activity [GO:0008926]; tagaturonate reductase activity [GO:0009026] GO:0005829; GO:0008926; GO:0009026; GO:0019592; GO:0019698 +P45527 UBIU_ECOLI Ubiquinone biosynthesis protein UbiU ubiU yhbU b3158 JW3127 yhbU ubiU 37,047 ubiquinone biosynthetic process from chorismate [GO:0032150] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; ubiquinone biosynthetic process from chorismate [GO:0032150] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0032150; GO:0046872; GO:0051539 +P0A8G0 UVRC_ECOLI UvrABC system protein C (Protein UvrC) (Excinuclease ABC subunit C) uvrC b1913 JW1898 uvrC 68,188 cellular response to DNA damage stimulus [GO:0006974]; nucleotide-excision repair [GO:0006289]; response to radiation [GO:0009314]; SOS response [GO:0009432] cytoplasm [GO:0005737]; excinuclease repair complex [GO:0009380] cytoplasm [GO:0005737]; excinuclease repair complex [GO:0009380]; DNA binding [GO:0003677]; excinuclease ABC activity [GO:0009381]; cellular response to DNA damage stimulus [GO:0006974]; nucleotide-excision repair [GO:0006289]; response to radiation [GO:0009314]; SOS response [GO:0009432] DNA binding [GO:0003677]; excinuclease ABC activity [GO:0009381] GO:0003677; GO:0005737; GO:0006289; GO:0006974; GO:0009314; GO:0009380; GO:0009381; GO:0009432 SUBCELLULAR LOCATION: Cytoplasm. +P00904 TRPGD_ECOLI Bifunctional protein TrpGD [Includes: Anthranilate synthase component 2 (AS) (ASII) (EC 4.1.3.27) (Anthranilate synthase, glutamine amidotransferase component); Anthranilate phosphoribosyltransferase (EC 2.4.2.18)] trpGD trpD b1263 JW1255 trpD trpGD 56,870 glutamine metabolic process [GO:0006541]; phenazine biosynthetic process [GO:0002047]; tryptophan biosynthetic process [GO:0000162] anthranilate phosphoribosyltransferase activity [GO:0004048]; anthranilate synthase activity [GO:0004049]; magnesium ion binding [GO:0000287]; glutamine metabolic process [GO:0006541]; phenazine biosynthetic process [GO:0002047]; tryptophan biosynthetic process [GO:0000162] anthranilate phosphoribosyltransferase activity [GO:0004048]; anthranilate synthase activity [GO:0004049]; magnesium ion binding [GO:0000287] GO:0000162; GO:0000287; GO:0002047; GO:0004048; GO:0004049; GO:0006541 +P07604 TYRR_ECOLI Transcriptional regulatory protein TyrR tyrR b1323 JW1316 tyrR 57,656 aromatic compound catabolic process [GO:0019439]; negative regulation of transcription, DNA-templated [GO:0045892]; phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; transcription factor binding [GO:0008134]; aromatic compound catabolic process [GO:0019439]; negative regulation of transcription, DNA-templated [GO:0045892]; phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] ATP binding [GO:0005524]; DNA binding [GO:0003677]; transcription factor binding [GO:0008134] GO:0000160; GO:0003677; GO:0005524; GO:0005829; GO:0006355; GO:0008134; GO:0019439; GO:0045892 +P07913 TDH_ECOLI L-threonine 3-dehydrogenase (TDH) (EC 1.1.1.103) (L-threonine dehydrogenase) tdh b3616 JW3591 tdh 37,239 L-serine biosynthetic process [GO:0006564]; L-threonine catabolic process to glycine [GO:0019518]; threonine catabolic process [GO:0006567] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; cadmium ion binding [GO:0046870]; ferrous iron binding [GO:0008198]; L-threonine 3-dehydrogenase activity [GO:0008743]; manganese ion binding [GO:0030145]; oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270]; L-serine biosynthetic process [GO:0006564]; L-threonine catabolic process to glycine [GO:0019518]; threonine catabolic process [GO:0006567] cadmium ion binding [GO:0046870]; ferrous iron binding [GO:0008198]; L-threonine 3-dehydrogenase activity [GO:0008743]; manganese ion binding [GO:0030145]; oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] GO:0005737; GO:0005829; GO:0006564; GO:0006567; GO:0008198; GO:0008270; GO:0008743; GO:0016491; GO:0019518; GO:0030145; GO:0046870 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00627}. +P60778 TSGA_ECOLI Protein TsgA tsgA gutS yhfC yhfH b3364 JW3327 gutS yhfC yhfH tsgA 43,166 response to selenite ion [GO:0072714] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; response to selenite ion [GO:0072714] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0022857; GO:0072714 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AAB4 UBID_ECOLI 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (EC 4.1.1.98) (Polyprenyl p-hydroxybenzoate decarboxylase) ubiD yigC yigY b3843 JW3819 yigC yigY ubiD 55,604 protein hexamerization [GO:0034214]; ubiquinone biosynthetic process [GO:0006744]; ubiquinone biosynthetic process from chorismate [GO:0032150] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity [GO:0008694]; carboxy-lyase activity [GO:0016831]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145]; protein hexamerization [GO:0034214]; ubiquinone biosynthetic process [GO:0006744]; ubiquinone biosynthetic process from chorismate [GO:0032150] 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity [GO:0008694]; carboxy-lyase activity [GO:0016831]; identical protein binding [GO:0042802]; manganese ion binding [GO:0030145] GO:0005737; GO:0005829; GO:0005886; GO:0006744; GO:0008694; GO:0016831; GO:0030145; GO:0032150; GO:0034214; GO:0042802 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01636, ECO:0000305|PubMed:782527}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01636, ECO:0000305|PubMed:782527}. +P17993 UBIG_ECOLI Ubiquinone biosynthesis O-methyltransferase (2-octaprenyl-6-hydroxyphenol methylase) (EC 2.1.1.222) (3-demethylubiquinone-8 3-O-methyltransferase) (EC 2.1.1.64) ubiG pufX yfaB b2232 JW2226 pufX yfaB ubiG 26,555 hyperosmotic salinity response [GO:0042538]; methylation [GO:0032259]; ubiquinone biosynthetic process [GO:0006744] cytosol [GO:0005829]; ubiquinone biosynthesis complex [GO:0110142] cytosol [GO:0005829]; ubiquinone biosynthesis complex [GO:0110142]; 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity [GO:0043431]; 2-polyprenyl-6-hydroxyphenol methylase activity [GO:0102208]; 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [GO:0008425]; 3-demethylubiquinol-8 3-O-methyltransferase activity [GO:0099119]; 3-demethylubiquinone-9 3-O-methyltransferase activity [GO:0008689]; phosphatidylglycerol binding [GO:1901611]; hyperosmotic salinity response [GO:0042538]; methylation [GO:0032259]; ubiquinone biosynthetic process [GO:0006744] 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity [GO:0043431]; 2-polyprenyl-6-hydroxyphenol methylase activity [GO:0102208]; 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [GO:0008425]; 3-demethylubiquinol-8 3-O-methyltransferase activity [GO:0099119]; 3-demethylubiquinone-9 3-O-methyltransferase activity [GO:0008689]; phosphatidylglycerol binding [GO:1901611] GO:0005829; GO:0006744; GO:0008425; GO:0008689; GO:0032259; GO:0042538; GO:0043431; GO:0099119; GO:0102208; GO:0110142; GO:1901611 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30686758}. +P0A870 TALB_ECOLI Transaldolase B (EC 2.2.1.2) talB yaaK b0008 JW0007 yaaK talB 35,219 carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt, non-oxidative branch [GO:0009052] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity [GO:0004801]; transferase activity, transferring aldehyde or ketonic groups [GO:0016744]; carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt, non-oxidative branch [GO:0009052] sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity [GO:0004801]; transferase activity, transferring aldehyde or ketonic groups [GO:0016744] GO:0004801; GO:0005829; GO:0005975; GO:0009052; GO:0016020; GO:0016744 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P23003 TRMA_ECOLI tRNA/tmRNA (uracil-C(5))-methyltransferase (EC 2.1.1.-) (EC 2.1.1.35) (tRNA (uracil(54)-C(5))-methyltransferase) (tRNA(m5U54)-methyltransferase) (RUMT) (tmRNA (uracil(341)-C(5))-methyltransferase) trmA b3965 JW3937 trmA 41,967 tRNA methylation [GO:0030488] cytosol [GO:0005829] cytosol [GO:0005829]; rRNA binding [GO:0019843]; S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity [GO:0030697]; tRNA binding [GO:0000049]; tRNA methylation [GO:0030488] rRNA binding [GO:0019843]; S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity [GO:0030697]; tRNA binding [GO:0000049] GO:0000049; GO:0005829; GO:0019843; GO:0030488; GO:0030697 +P25396 TEHA_ECOLI Tellurite resistance protein TehA tehA b1429 JW1425 tehA 35,932 cation transport [GO:0006812]; response to antibiotic [GO:0046677]; response to tellurium ion [GO:0046690]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cation efflux transmembrane transporter activity [GO:0046583]; identical protein binding [GO:0042802]; cation transport [GO:0006812]; response to antibiotic [GO:0046677]; response to tellurium ion [GO:0046690]; transmembrane transport [GO:0055085] cation efflux transmembrane transporter activity [GO:0046583]; identical protein binding [GO:0042802] GO:0005886; GO:0006812; GO:0016021; GO:0042802; GO:0046583; GO:0046677; GO:0046690; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A9W0 ULAR_ECOLI HTH-type transcriptional regulator UlaR ulaR yjfQ b4191 JW4149 yjfQ ulaR 27,602 negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; L-ascorbic acid binding [GO:0031418]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; L-ascorbic acid binding [GO:0031418] GO:0003677; GO:0003700; GO:0005737; GO:0006351; GO:0031418; GO:0045892 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A847 TGT_ECOLI Queuine tRNA-ribosyltransferase (EC 2.4.2.29) (Guanine insertion enzyme) (tRNA-guanine transglycosylase) tgt b0406 JW0396 tgt 42,594 queuosine biosynthetic process [GO:0008616]; tRNA-guanine transglycosylation [GO:0101030]; tRNA wobble guanine modification [GO:0002099] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; queuine tRNA-ribosyltransferase activity [GO:0008479]; zinc ion binding [GO:0008270]; queuosine biosynthetic process [GO:0008616]; tRNA wobble guanine modification [GO:0002099]; tRNA-guanine transglycosylation [GO:0101030] queuine tRNA-ribosyltransferase activity [GO:0008479]; zinc ion binding [GO:0008270] GO:0002099; GO:0005737; GO:0005829; GO:0008270; GO:0008479; GO:0008616; GO:0101030 +P45748 TSAC_ECOLI Threonylcarbamoyl-AMP synthase (TC-AMP synthase) (EC 2.7.7.87) (L-threonylcarbamoyladenylate synthase) (Ribosome maturation factor TsaC) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC) (tRNA threonylcarbamoyladenosine biosynthesis protein TsaC) tsaC rimN yrdC b3282 JW3243 rimN yrdC tsaC 20,768 regulation of translational fidelity [GO:0006450]; rRNA processing [GO:0006364]; tRNA threonylcarbamoyladenosine modification [GO:0002949] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; L-threonylcarbamoyladenylate synthase [GO:0061710]; nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049]; regulation of translational fidelity [GO:0006450]; rRNA processing [GO:0006364]; tRNA threonylcarbamoyladenosine modification [GO:0002949] ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; L-threonylcarbamoyladenylate synthase [GO:0061710]; nucleotidyltransferase activity [GO:0016779]; tRNA binding [GO:0000049] GO:0000049; GO:0002949; GO:0003725; GO:0005524; GO:0005737; GO:0005829; GO:0006364; GO:0006450; GO:0016779; GO:0061710 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01852}. +P30138 THIF_ECOLI Sulfur carrier protein ThiS adenylyltransferase (EC 2.7.7.73) thiF b3992 JW3956 thiF 26,970 thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; nucleotidyltransferase activity [GO:0016779]; ubiquitin-like modifier activating enzyme activity [GO:0008641]; zinc ion binding [GO:0008270]; thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; metal ion binding [GO:0046872]; nucleotidyltransferase activity [GO:0016779]; ubiquitin-like modifier activating enzyme activity [GO:0008641]; zinc ion binding [GO:0008270] GO:0000287; GO:0005524; GO:0005737; GO:0005829; GO:0008270; GO:0008641; GO:0009228; GO:0009229; GO:0016779; GO:0046872 +P30136 THIC_ECOLI Phosphomethylpyrimidine synthase (EC 4.1.99.17) (Hydroxymethylpyrimidine phosphate synthase) (HMP-P synthase) (HMP-phosphate synthase) (HMPP synthase) (Thiamine biosynthesis protein ThiC) thiC b3994 JW3958 thiC 70,850 thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; carbon-carbon lyase activity [GO:0016830]; zinc ion binding [GO:0008270]; thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] 4 iron, 4 sulfur cluster binding [GO:0051539]; carbon-carbon lyase activity [GO:0016830]; zinc ion binding [GO:0008270] GO:0005829; GO:0008270; GO:0009228; GO:0009229; GO:0016830; GO:0051539 +P27302 TKT1_ECOLI Transketolase 1 (TK 1) (EC 2.2.1.1) tktA tkt b2935 JW5478 tkt tktA 72,212 pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052] cytosol [GO:0005829] cytosol [GO:0005829]; manganese ion binding [GO:0030145]; thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052] manganese ion binding [GO:0030145]; thiamine pyrophosphate binding [GO:0030976]; transketolase activity [GO:0004802] GO:0004802; GO:0005829; GO:0006098; GO:0009052; GO:0030145; GO:0030976 +P0A873 TRMD_ECOLI tRNA (guanine-N(1)-)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) trmD b2607 JW2588 trmD 28,422 tRNA methylation [GO:0030488]; tRNA N1-guanine methylation [GO:0002939] cytosol [GO:0005829] cytosol [GO:0005829]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; tRNA (guanine(37)-N(1))-methyltransferase activity [GO:0052906]; tRNA (guanine-N1-)-methyltransferase activity [GO:0009019]; tRNA methylation [GO:0030488]; tRNA N1-guanine methylation [GO:0002939] identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; tRNA (guanine(37)-N(1))-methyltransferase activity [GO:0052906]; tRNA (guanine-N1-)-methyltransferase activity [GO:0009019] GO:0000287; GO:0002939; GO:0005829; GO:0009019; GO:0030488; GO:0042802; GO:0052906 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P38684 TORR_ECOLI TorCAD operon transcriptional regulatory protein TorR torR b0995 JW0980 torR 26,233 regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000976; GO:0001216; GO:0005829; GO:0006355; GO:0032993 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P05852 TSAD_ECOLI tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD) (tRNA threonylcarbamoyladenosine biosynthesis protein TsaD) tsaD gcp ygjD b3064 JW3036 gcp ygjD tsaD 36,008 tRNA threonylcarbamoyladenosine modification [GO:0002949] cytosol [GO:0005829] cytosol [GO:0005829]; glycosylation-dependent protein binding [GO:0140032]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; magnesium ion binding [GO:0000287]; N(6)-L-threonylcarbamoyladenine synthase activity [GO:0061711]; tRNA threonylcarbamoyladenosine modification [GO:0002949] glycosylation-dependent protein binding [GO:0140032]; identical protein binding [GO:0042802]; iron ion binding [GO:0005506]; magnesium ion binding [GO:0000287]; N(6)-L-threonylcarbamoyladenine synthase activity [GO:0061711] GO:0000287; GO:0002949; GO:0005506; GO:0005829; GO:0042802; GO:0061711; GO:0140032 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01445, ECO:0000269|PubMed:19376873}. +P07118 SYV_ECOLI Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) valS b4258 JW4215 valS 108,192 cytosolic valyl-tRNA aminoacylation [GO:0061475]; positive regulation of translational fidelity [GO:0045903]; valyl-tRNA aminoacylation [GO:0006438] cytosol [GO:0005829] cytosol [GO:0005829]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; valine-tRNA ligase activity [GO:0004832]; cytosolic valyl-tRNA aminoacylation [GO:0061475]; positive regulation of translational fidelity [GO:0045903]; valyl-tRNA aminoacylation [GO:0006438] aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; valine-tRNA ligase activity [GO:0004832] GO:0000287; GO:0002161; GO:0004832; GO:0005524; GO:0005829; GO:0006438; GO:0045903; GO:0061475 SUBCELLULAR LOCATION: Cytoplasm. +P00962 SYQ_ECOLI Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) glnS b0680 JW0666 glnS 63,478 glutaminyl-tRNA aminoacylation [GO:0006425]; glutamyl-tRNA aminoacylation [GO:0006424] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; glutaminyl-tRNA aminoacylation [GO:0006425]; glutamyl-tRNA aminoacylation [GO:0006424] ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819] GO:0004819; GO:0005524; GO:0005829; GO:0006424; GO:0006425 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00126}. +P46923 TORZ_ECOLI Trimethylamine-N-oxide reductase 2 (TMAO reductase 2) (Trimethylamine oxidase 2) (EC 1.7.2.3) torZ bisZ b1872 JW1861 bisZ torZ 88,964 anaerobic respiration [GO:0009061] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; electron transfer activity [GO:0009055]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; trimethylamine-N-oxide reductase (cytochrome c) activity [GO:0050626]; anaerobic respiration [GO:0009061] electron transfer activity [GO:0009055]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; trimethylamine-N-oxide reductase (cytochrome c) activity [GO:0050626] GO:0009055; GO:0009061; GO:0030151; GO:0030288; GO:0043546; GO:0050626 SUBCELLULAR LOCATION: Periplasm. +P38683 TORT_ECOLI Periplasmic protein TorT torT yccH b0994 JW0979 yccH torT 37,865 anaerobic respiration [GO:0009061]; regulation of transcription, DNA-templated [GO:0006355] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; anaerobic respiration [GO:0009061]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355; GO:0009061; GO:0042597 SUBCELLULAR LOCATION: Periplasm. +P0A853 TNAA_ECOLI Tryptophanase (EC 4.1.99.1) (L-tryptophan indole-lyase) (TNase) tnaA ind b3708 JW3686 ind tnaA 52,773 tryptophan catabolic process [GO:0006569] cell pole [GO:0060187]; cytosol [GO:0005829]; membrane [GO:0016020]; protein-containing complex [GO:0032991] cell pole [GO:0060187]; cytosol [GO:0005829]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; L-cysteine desulfhydrase activity [GO:0080146]; potassium ion binding [GO:0030955]; pyridoxal phosphate binding [GO:0030170]; tryptophanase activity [GO:0009034]; tryptophan catabolic process [GO:0006569] identical protein binding [GO:0042802]; L-cysteine desulfhydrase activity [GO:0080146]; potassium ion binding [GO:0030955]; pyridoxal phosphate binding [GO:0030170]; tryptophanase activity [GO:0009034] GO:0005829; GO:0006569; GO:0009034; GO:0016020; GO:0030170; GO:0030955; GO:0032991; GO:0042802; GO:0060187; GO:0080146 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:22380631}. Note=Almost exclusively localized in foci near 1 cell pole in mid-to-late exponential phase, fewer cells have foci at stationary phase; polar localization depends on the minCDE operon. +P09153 TFAE_ECOLI Prophage tail fiber assembly protein homolog TfaE (Tail fiber assembly protein homolog from lambdoid prophage e14) tfaE ycfA b1156 JW1142 ycfA tfaE 21,662 +P76155 TFAQ_ECOLI Prophage tail fiber assembly protein homolog TfaQ (Tail fiber assembly protein homolog from lambdoid prophage Qin) tfaQ ydfM b1546 JW1539 ydfM tfaQ 21,338 +P37025 THPR_ECOLI RNA 2',3'-cyclic phosphodiesterase (RNA 2',3'-CPDase) (EC 3.1.4.58) (Two-histidine 2',3'-cyclic phosphodiesterase acting on RNA) thpR ligT yadP b0147 JW5011 ligT yadP thpR 19,934 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [GO:0004113]; 2'-5'-RNA ligase activity [GO:0008664] 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [GO:0004113]; 2'-5'-RNA ligase activity [GO:0008664] GO:0004113; GO:0008664 +P0AEM9 TCYJ_ECOLI L-cystine-binding protein TcyJ (CBP) (Protein FliY) (Sulfate starvation-induced protein 7) (SSI7) tcyJ fliY yzzR b1920 JW1905 fliY yzzR tcyJ 29,039 L-cystine transport [GO:0015811]; sulfur utilization [GO:0006791] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288] membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; amino acid binding [GO:0016597]; L-cystine transmembrane transporter activity [GO:0015184]; ligand-gated ion channel activity [GO:0015276]; L-cystine transport [GO:0015811]; sulfur utilization [GO:0006791] amino acid binding [GO:0016597]; L-cystine transmembrane transporter activity [GO:0015184]; ligand-gated ion channel activity [GO:0015276] GO:0006791; GO:0015184; GO:0015276; GO:0015811; GO:0016020; GO:0016597; GO:0030288 SUBCELLULAR LOCATION: Periplasm {ECO:0000305|PubMed:20351115}. +Q46821 UACT_ECOLI Uric acid transporter UacT uacT ygfU b2888 JW5470 ygfU uacT 51,758 urate transport [GO:0015747]; xanthine transport [GO:0042906] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; symporter activity [GO:0015293]; urate transmembrane transporter activity [GO:0015143]; xanthine transmembrane transporter activity [GO:0042907]; urate transport [GO:0015747]; xanthine transport [GO:0042906] symporter activity [GO:0015293]; urate transmembrane transporter activity [GO:0015143]; xanthine transmembrane transporter activity [GO:0042907] GO:0005886; GO:0005887; GO:0015143; GO:0015293; GO:0015747; GO:0042906; GO:0042907 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:22437829}; Multi-pass membrane protein {ECO:0000269|PubMed:22437829}. +P29018 CYDD_ECOLI ATP-binding/permease protein CydD cydD htrD b0887 JW0870 htrD cydD 65,056 cell redox homeostasis [GO:0045454]; cysteine export across plasma membrane [GO:0033228]; glutathione transmembrane transport [GO:0034775]; transmembrane transport [GO:0055085] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; cell redox homeostasis [GO:0045454]; cysteine export across plasma membrane [GO:0033228]; glutathione transmembrane transport [GO:0034775]; transmembrane transport [GO:0055085] ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0005887; GO:0016020; GO:0016887; GO:0033228; GO:0034775; GO:0042626; GO:0043190; GO:0045454; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:15919996}. +P24171 DCP_ECOLI Dipeptidyl carboxypeptidase (EC 3.4.15.5) (Peptidyl-dipeptidase Dcp) dcp b1538 JW1531 dcp 77,516 proteolysis [GO:0006508] cytoplasm [GO:0005737]; cytosol [GO:0005829]; outer membrane-bounded periplasmic space [GO:0030288] cytoplasm [GO:0005737]; cytosol [GO:0005829]; outer membrane-bounded periplasmic space [GO:0030288]; carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; proteolysis [GO:0006508] carboxypeptidase activity [GO:0004180]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] GO:0004180; GO:0004222; GO:0005737; GO:0005829; GO:0006508; GO:0008237; GO:0030288; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:8226676}. +P0AEB2 DACA_ECOLI D-alanyl-D-alanine carboxypeptidase DacA (DD-carboxypeptidase) (DD-peptidase) (EC 3.4.16.4) (Beta-lactamase) (EC 3.5.2.6) (Penicillin-binding protein 5) (PBP-5) dacA pfv b0632 JW0627 pfv dacA 44,444 cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan metabolic process [GO:0000270]; regulation of cell shape [GO:0008360] integral component of periplasmic side of plasma membrane [GO:1990914]; integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] integral component of periplasmic side of plasma membrane [GO:1990914]; integral component of plasma membrane [GO:0005887]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; beta-lactamase activity [GO:0008800]; carboxypeptidase activity [GO:0004180]; penicillin binding [GO:0008658]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan metabolic process [GO:0000270]; regulation of cell shape [GO:0008360] beta-lactamase activity [GO:0008800]; carboxypeptidase activity [GO:0004180]; penicillin binding [GO:0008658]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002] GO:0000270; GO:0004180; GO:0005886; GO:0005887; GO:0008360; GO:0008658; GO:0008800; GO:0009002; GO:0009252; GO:0030288; GO:0071555; GO:1990914 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=N-terminal lies in the periplasmic space. +P77381 DJLB_ECOLI Uncharacterized J domain-containing protein DjlB djlB ybeS b0646 JW0641 ybeS djlB 55,256 +P69054 DHSC_ECOLI Succinate dehydrogenase cytochrome b556 subunit (Cytochrome b-556) sdhC cybA b0721 JW0711 cybA sdhC 14,299 aerobic respiration [GO:0009060]; cytochrome complex assembly [GO:0017004]; tricarboxylic acid cycle [GO:0006099] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; succinate dehydrogenase complex [GO:0045281] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; succinate dehydrogenase complex [GO:0045281]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; succinate dehydrogenase (ubiquinone) activity [GO:0008177]; ubiquinone binding [GO:0048039]; aerobic respiration [GO:0009060]; cytochrome complex assembly [GO:0017004]; tricarboxylic acid cycle [GO:0006099] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; succinate dehydrogenase (ubiquinone) activity [GO:0008177]; ubiquinone binding [GO:0048039] GO:0005886; GO:0006099; GO:0008177; GO:0009055; GO:0009060; GO:0016021; GO:0017004; GO:0020037; GO:0045281; GO:0046872; GO:0048039 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0ABP8 DEOD_ECOLI Purine nucleoside phosphorylase DeoD-type (PNP) (EC 2.4.2.1) deoD pup b4384 JW4347 pup deoD 25,950 cellular response to DNA damage stimulus [GO:0006974]; purine nucleoside catabolic process [GO:0006152]; purine nucleoside interconversion [GO:0019686] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; guanosine phosphorylase activity [GO:0047975]; identical protein binding [GO:0042802]; purine-nucleoside phosphorylase activity [GO:0004731]; cellular response to DNA damage stimulus [GO:0006974]; purine nucleoside catabolic process [GO:0006152]; purine nucleoside interconversion [GO:0019686] guanosine phosphorylase activity [GO:0047975]; identical protein binding [GO:0042802]; purine-nucleoside phosphorylase activity [GO:0004731] GO:0004731; GO:0005829; GO:0006152; GO:0006974; GO:0016020; GO:0019686; GO:0042802; GO:0047975 +Q6BF16 DGOA_ECOLI 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (EC 4.1.2.21) (2-oxo-3-deoxygalactonate 6-phosphate aldolase) (6-phospho-2-dehydro-3-deoxygalactonate aldolase) (6-phospho-2-keto-3-deoxygalactonate aldolase) (KDPGal) dgoA yidU b4477 JW5628 yidU dgoA 21,391 D-galactonate catabolic process [GO:0034194] 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity [GO:0008674]; D-galactonate catabolic process [GO:0034194] 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity [GO:0008674] GO:0008674; GO:0034194 +P76129 DOSP_ECOLI Oxygen sensor protein DosP (EC 3.1.4.52) (Direct oxygen-sensing phosphodiesterase) (Direct oxygen sensor protein) (Ec DOS) (Heme-regulated cyclic di-GMP phosphodiesterase) dosP dos pdeO yddU b1489 JW1484 dos pdeO yddU dosP 90,260 response to oxygen levels [GO:0070482] cyclic-guanylate-specific phosphodiesterase activity [GO:0071111]; heme binding [GO:0020037]; magnesium ion binding [GO:0000287]; oxygen sensor activity [GO:0019826]; response to oxygen levels [GO:0070482] cyclic-guanylate-specific phosphodiesterase activity [GO:0071111]; heme binding [GO:0020037]; magnesium ion binding [GO:0000287]; oxygen sensor activity [GO:0019826] GO:0000287; GO:0019826; GO:0020037; GO:0070482; GO:0071111 +P0AEG1 DPPC_ECOLI Dipeptide transport system permease protein DppC dppC b3542 JW3511 dppC 32,308 protein transport [GO:0015031] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; dipeptide transmembrane transporter activity [GO:0071916]; protein transport [GO:0015031] dipeptide transmembrane transporter activity [GO:0071916] GO:0005886; GO:0015031; GO:0016021; GO:0071916 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein. +P75942 FLGJ_ECOLI Peptidoglycan hydrolase FlgJ (EC 3.2.1.-) (Muramidase FlgJ) flgJ fla FX flaZ b1081 JW1068 fla FX flaZ flgJ 34,475 bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973]; cell wall organization [GO:0071555]; metabolic process [GO:0008152] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; amidase activity [GO:0004040]; hydrolase activity, acting on glycosyl bonds [GO:0016798]; bacterial-type flagellum assembly [GO:0044780]; bacterial-type flagellum-dependent cell motility [GO:0071973]; cell wall organization [GO:0071555]; metabolic process [GO:0008152] amidase activity [GO:0004040]; hydrolase activity, acting on glycosyl bonds [GO:0016798] GO:0004040; GO:0008152; GO:0016798; GO:0042597; GO:0044780; GO:0071555; GO:0071973 SUBCELLULAR LOCATION: Periplasm {ECO:0000250}. +P0ABY7 FLHC_ECOLI Flagellar transcriptional regulator FlhC flhC flaI b1891 JW1880 flaI flhC 21,566 bacterial-type flagellum organization [GO:0044781]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of bacterial-type flagellum assembly [GO:1902208]; transcription, DNA-templated [GO:0006351] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; bacterial-type flagellum organization [GO:0044781]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of bacterial-type flagellum assembly [GO:1902208]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; zinc ion binding [GO:0008270] GO:0003677; GO:0005737; GO:0006351; GO:0008270; GO:0044781; GO:0045893; GO:1902208 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P80668 FEAB_ECOLI Phenylacetaldehyde dehydrogenase (PAD) (EC 1.2.1.39) feaB maoB padA ydbG b1385 JW1380 maoB padA ydbG feaB 53,699 4-nitrophenol catabolic process [GO:0046196]; L-phenylalanine catabolic process [GO:0006559]; NAD biosynthetic process [GO:0009435]; phenylethylamine catabolic process [GO:0019607] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; 4-hydroxyphenylacetaldehyde dehydrogenase activity [GO:0047106]; oxidoreductase activity [GO:0016491]; phenylacetaldehyde dehydrogenase activity [GO:0008957]; 4-nitrophenol catabolic process [GO:0046196]; L-phenylalanine catabolic process [GO:0006559]; NAD biosynthetic process [GO:0009435]; phenylethylamine catabolic process [GO:0019607] 4-hydroxyphenylacetaldehyde dehydrogenase activity [GO:0047106]; oxidoreductase activity [GO:0016491]; phenylacetaldehyde dehydrogenase activity [GO:0008957] GO:0006559; GO:0008957; GO:0009435; GO:0016491; GO:0019607; GO:0032991; GO:0046196; GO:0047106 +P63235 GADC_ECOLI Glutamate/gamma-aminobutyrate antiporter (Glu/GABA antiporter) (Extreme acid sensitivity protein) gadC acsA xasA b1492 JW1487 acsA xasA gadC 55,077 amino acid transport [GO:0006865]; intracellular pH elevation [GO:0051454] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297]; amino acid transport [GO:0006865]; intracellular pH elevation [GO:0051454] antiporter activity [GO:0015297] GO:0005886; GO:0006865; GO:0015297; GO:0016021; GO:0051454 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:22407317}; Multi-pass membrane protein {ECO:0000269|PubMed:22407317}. +P0AEN1 FRE_ECOLI NAD(P)H-flavin reductase (EC 1.5.1.41) (FMN reductase) (Ferrisiderophore reductase C) (NAD(P)H:flavin oxidoreductase) (Riboflavin reductase [NAD(P)H]) fre fadI flrD fsrC ubiB b3844 JW3820 fadI flrD fsrC ubiB fre 26,242 ion transport [GO:0006811]; iron ion homeostasis [GO:0055072]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979] cytosol [GO:0005829] cytosol [GO:0005829]; enzyme activator activity [GO:0008047]; riboflavin reductase (NADH) activity [GO:0052875]; riboflavin reductase (NADPH) activity [GO:0042602]; ion transport [GO:0006811]; iron ion homeostasis [GO:0055072]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979] enzyme activator activity [GO:0008047]; riboflavin reductase (NADH) activity [GO:0052875]; riboflavin reductase (NADPH) activity [GO:0042602] GO:0005829; GO:0006811; GO:0006979; GO:0008047; GO:0030091; GO:0042602; GO:0052875; GO:0055072 +P29131 FTSN_ECOLI Cell division protein FtsN ftsN msgA b3933 JW3904 msgA ftsN 35,793 cell division [GO:0051301]; division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093] cell septum [GO:0030428]; division septum [GO:0000935]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cell septum [GO:0030428]; division septum [GO:0000935]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; peptidoglycan binding [GO:0042834]; cell division [GO:0051301]; division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093] peptidoglycan binding [GO:0042834] GO:0000917; GO:0000935; GO:0005886; GO:0005887; GO:0030428; GO:0042834; GO:0043093; GO:0051301 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:8631709}; Single-pass type II membrane protein {ECO:0000269|PubMed:8631709}. Note=Localizes to the septum (PubMed:9282742, PubMed:19684127, PubMed:24750258). Localizes to the midcell via interaction with the early cell division protein FtsA and via the periplasmic SPOR domain (PubMed:9282742, PubMed:19684127, PubMed:24750258). FtsA-dependent localization precedes SPOR-dependent localization, and both are needed for efficient localization (PubMed:24750258). Localization depends upon FtsZ, FtsA, ZipA, FtsQ and FtsI (PubMed:9282742, PubMed:11948172). {ECO:0000269|PubMed:11948172, ECO:0000269|PubMed:19684127, ECO:0000269|PubMed:24750258, ECO:0000269|PubMed:9282742}. +P52074 GLCF_ECOLI Glycolate oxidase iron-sulfur subunit (EC 1.1.99.14) (Glycolate dehydrogenase subunit GlcF) (Glycolate oxidase subunit GlcF) glcF gox yghL b4467 JW5486 gox yghL glcF 45,110 glycolate catabolic process [GO:0046296] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; 4 iron, 4 sulfur cluster binding [GO:0051539]; D-2-hydroxy-acid dehydrogenase activity [GO:0047809]; glycolate dehydrogenase activity [GO:0019154]; metal ion binding [GO:0046872]; glycolate catabolic process [GO:0046296] 4 iron, 4 sulfur cluster binding [GO:0051539]; D-2-hydroxy-acid dehydrogenase activity [GO:0047809]; glycolate dehydrogenase activity [GO:0019154]; metal ion binding [GO:0046872] GO:0005886; GO:0019154; GO:0046296; GO:0046872; GO:0047809; GO:0051539 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:2689218, ECO:0000305|PubMed:8606183}. Note=Glycolate oxidoreductase activity was shown to be firmly associated with the cytoplasmic membranes (PubMed:2689218). And the GlcF subunit itself could only be detected in the membrane fraction (PubMed:8606183). {ECO:0000269|PubMed:2689218, ECO:0000269|PubMed:8606183}. +P0A9I3 GCVR_ECOLI Glycine cleavage system transcriptional repressor (gcv operon repressor) gcvR yffD b2479 JW2464 yffD gcvR 20,769 regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] cytosol [GO:0005829] cytosol [GO:0005829]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] GO:0005829; GO:0006351; GO:0006355 SUBCELLULAR LOCATION: Cytoplasm. +P21437 GLPX2_ECOLI Fructose-1,6-bisphosphatase 2 class 2 (FBPase 2 class 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 2 class 2) yggF yggK b2930 JW2897 yggK yggF 34,323 fructose 1,6-bisphosphate metabolic process [GO:0030388]; gluconeogenesis [GO:0006094]; glycerol metabolic process [GO:0006071] fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; manganese ion binding [GO:0030145]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; gluconeogenesis [GO:0006094]; glycerol metabolic process [GO:0006071] fructose 1,6-bisphosphate 1-phosphatase activity [GO:0042132]; manganese ion binding [GO:0030145] GO:0006071; GO:0006094; GO:0030145; GO:0030388; GO:0042132 +P0A9C0 GLPA_ECOLI Anaerobic glycerol-3-phosphate dehydrogenase subunit A (G-3-P dehydrogenase) (EC 1.1.5.3) glpA b2241 JW2235 glpA 58,958 anaerobic respiration [GO:0009061]; glycerol-3-phosphate catabolic process [GO:0046168]; glycerol catabolic process [GO:0019563] cytosol [GO:0005829]; glycerol-3-phosphate dehydrogenase complex [GO:0009331]; plasma membrane [GO:0005886] cytosol [GO:0005829]; glycerol-3-phosphate dehydrogenase complex [GO:0009331]; plasma membrane [GO:0005886]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368]; sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity [GO:0052591]; anaerobic respiration [GO:0009061]; glycerol catabolic process [GO:0019563]; glycerol-3-phosphate catabolic process [GO:0046168] flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; glycerol-3-phosphate dehydrogenase (quinone) activity [GO:0004368]; sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity [GO:0052591] GO:0004368; GO:0005829; GO:0005886; GO:0009061; GO:0009331; GO:0010181; GO:0019563; GO:0046168; GO:0050660; GO:0052591 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase. +P77335 HLYE_ECOLI Hemolysin E, chromosomal (Cytotoxin ClyA) (Hemolysis-inducing protein) (Latent pore-forming 34 kDa hemolysin) (Silent hemolysin SheA) hlyE clyA hpr sheA ycgD b1182 JW5181 clyA hpr sheA ycgD hlyE 33,759 cytolysis by symbiont of host cells [GO:0001897]; hemolysis in other organism [GO:0044179]; modulation of apoptotic process in other organism [GO:0044532]; pathogenesis [GO:0009405] extracellular region [GO:0005576]; host cell plasma membrane [GO:0020002]; integral component of membrane [GO:0016021]; periplasmic space [GO:0042597] extracellular region [GO:0005576]; host cell plasma membrane [GO:0020002]; integral component of membrane [GO:0016021]; periplasmic space [GO:0042597]; identical protein binding [GO:0042802]; toxin activity [GO:0090729]; cytolysis by symbiont of host cells [GO:0001897]; hemolysis in other organism [GO:0044179]; modulation of apoptotic process in other organism [GO:0044532]; pathogenesis [GO:0009405] identical protein binding [GO:0042802]; toxin activity [GO:0090729] GO:0001897; GO:0005576; GO:0009405; GO:0016021; GO:0020002; GO:0042597; GO:0042802; GO:0044179; GO:0044532; GO:0090729 SUBCELLULAR LOCATION: Secreted. Periplasm. Host cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Exported from the cell by outer membrane vesicles. Also found in the periplasmic space. +P39346 IDND_ECOLI L-idonate 5-dehydrogenase (NAD(P)(+)) (EC 1.1.1.264) idnD yjgV b4267 JW4224 yjgV idnD 37,147 D-gluconate metabolic process [GO:0019521]; L-idonate catabolic process [GO:0046183] L-idonate 5-dehydrogenase activity [GO:0050572]; L-idonate 5-dehydrogenase activity (NAD-dependent) [GO:0102198]; metal ion binding [GO:0046872]; D-gluconate metabolic process [GO:0019521]; L-idonate catabolic process [GO:0046183] L-idonate 5-dehydrogenase activity [GO:0050572]; L-idonate 5-dehydrogenase activity (NAD-dependent) [GO:0102198]; metal ion binding [GO:0046872] GO:0019521; GO:0046183; GO:0046872; GO:0050572; GO:0102198 +U3PVA8 IROK_ECOLI Protein IroK (3-hydroxypropionic acid resistance peptide) iroK b4706 iroK 2,330 +P07017 MCP2_ECOLI Methyl-accepting chemotaxis protein II (MCP-II) (Aspartate chemoreceptor protein) tar cheM b1886 JW1875 cheM tar 59,944 cellular response to amino acid stimulus [GO:0071230]; chemotaxis [GO:0006935]; detection of chemical stimulus [GO:0009593]; positive regulation of post-translational protein modification [GO:1901875]; regulation of chemotaxis [GO:0050920]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165] cell tip [GO:0051286]; integral component of plasma membrane [GO:0005887]; methyl accepting chemotaxis protein complex [GO:0098561] cell tip [GO:0051286]; integral component of plasma membrane [GO:0005887]; methyl accepting chemotaxis protein complex [GO:0098561]; identical protein binding [GO:0042802]; protein histidine kinase binding [GO:0043424]; protein homodimerization activity [GO:0042803]; transmembrane signaling receptor activity [GO:0004888]; cellular response to amino acid stimulus [GO:0071230]; chemotaxis [GO:0006935]; detection of chemical stimulus [GO:0009593]; positive regulation of post-translational protein modification [GO:1901875]; regulation of chemotaxis [GO:0050920]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165] identical protein binding [GO:0042802]; protein histidine kinase binding [GO:0043424]; protein homodimerization activity [GO:0042803]; transmembrane signaling receptor activity [GO:0004888] GO:0004888; GO:0005887; GO:0006935; GO:0007165; GO:0007172; GO:0009593; GO:0042802; GO:0042803; GO:0043424; GO:0050920; GO:0051286; GO:0071230; GO:0098561; GO:1901875 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:22380631}; Multi-pass membrane protein {ECO:0000269|PubMed:22380631}. Note=Found predominantly at cell poles. +P60546 KGUA_ECOLI Guanylate kinase (EC 2.7.4.8) (GMP kinase) gmk spoR b3648 JW3623 spoR gmk 23,593 cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385]; identical protein binding [GO:0042802] ATP binding [GO:0005524]; guanylate kinase activity [GO:0004385]; identical protein binding [GO:0042802] GO:0004385; GO:0005524; GO:0005829; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm. +P0CF42 INSC3_ECOLI Transposase InsC for insertion element IS2F insC3 b1997 JW1978 insC3 13,452 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P46130 YBHC_ECOLI Putative acyl-CoA thioester hydrolase YbhC (EC 3.1.2.-) ybhC b0772 JW0755 ybhC 46,082 cell wall modification [GO:0042545] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; aspartyl esterase activity [GO:0045330]; carboxylic ester hydrolase activity [GO:0052689]; pectinesterase activity [GO:0030599]; cell wall modification [GO:0042545] aspartyl esterase activity [GO:0045330]; carboxylic ester hydrolase activity [GO:0052689]; pectinesterase activity [GO:0030599] GO:0009279; GO:0030599; GO:0042545; GO:0045330; GO:0052689 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P0AAY6 YBJN_ECOLI Uncharacterized protein YbjN ybjN b0853 JW0837 ybjN 17,666 negative regulation of bacterial-type flagellum assembly [GO:1902209]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201]; negative regulation of cell growth [GO:0030308]; negative regulation of single-species biofilm formation on inanimate substrate [GO:1900232]; pilus assembly [GO:0009297]; response to ionizing radiation [GO:0010212] negative regulation of bacterial-type flagellum assembly [GO:1902209]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201]; negative regulation of cell growth [GO:0030308]; negative regulation of single-species biofilm formation on inanimate substrate [GO:1900232]; pilus assembly [GO:0009297]; response to ionizing radiation [GO:0010212] GO:0009297; GO:0010212; GO:0030308; GO:1900232; GO:1902201; GO:1902209 +P75691 YAHK_ECOLI Aldehyde reductase YahK (EC 1.1.1.2) (Zinc-dependent alcohol dehydrogenase YahK) yahK b0325 JW0317 yahK 37,978 alcohol dehydrogenase (NADP+) activity [GO:0008106]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; zinc ion binding [GO:0008270] alcohol dehydrogenase (NADP+) activity [GO:0008106]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; zinc ion binding [GO:0008270] GO:0008106; GO:0008270; GO:0016616 +P51024 YAIL_ECOLI Uncharacterized protein YaiL yaiL b0354 JW0345 yaiL 19,923 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +Q2EEQ8 YBFQ_ECOLI Inactive transposase YbfQ ybfQ b4514 JW0694 ybfQ 9,555 +P0AFP4 YBBO_ECOLI Uncharacterized oxidoreductase YbbO (EC 1.-.-.-) ybbO b0493 JW0482 ybbO 29,410 alcohol dehydrogenase (NADP+) activity [GO:0008106] alcohol dehydrogenase (NADP+) activity [GO:0008106] GO:0008106 +Q47269 YBCN_ECOLI Uncharacterized protein YbcN ybcN b0547 JW0535 ybcN 17,433 bubble DNA binding [GO:0000405]; single-stranded DNA binding [GO:0003697] bubble DNA binding [GO:0000405]; single-stranded DNA binding [GO:0003697] GO:0000405; GO:0003697 +P76201 YDIQ_ECOLI Putative electron transfer flavoprotein subunit YdiQ ydiQ b1697 JW5276 ydiQ 27,470 cellular response to DNA damage stimulus [GO:0006974] electron transfer activity [GO:0009055]; cellular response to DNA damage stimulus [GO:0006974] electron transfer activity [GO:0009055] GO:0006974; GO:0009055 +P76481 YFBK_ECOLI Uncharacterized protein YfbK yfbK b2270 JW2265 yfbK 63,634 +P76097 YDCJ_ECOLI Uncharacterized protein YdcJ ydcJ b1423 JW1419 ydcJ 51,043 +P11864 YHAC_ECOLI Uncharacterized protein YhaC (ORF B') (ORFX) yhaC b3121 JW3092 yhaC 45,251 cellular response to DNA damage stimulus [GO:0006974] cellular response to DNA damage stimulus [GO:0006974] GO:0006974 +P33362 YEHZ_ECOLI Glycine betaine-binding protein YehZ yehZ osmF b2131 JW2119 osmF yehZ 32,609 amino acid transport [GO:0006865]; cellular hyperosmotic response [GO:0071474]; glycine betaine transport [GO:0031460] ATP-binding cassette (ABC) transporter complex [GO:0043190]; periplasmic space [GO:0042597] ATP-binding cassette (ABC) transporter complex [GO:0043190]; periplasmic space [GO:0042597]; transmembrane transporter activity [GO:0022857]; amino acid transport [GO:0006865]; cellular hyperosmotic response [GO:0071474]; glycine betaine transport [GO:0031460] transmembrane transporter activity [GO:0022857] GO:0006865; GO:0022857; GO:0031460; GO:0042597; GO:0043190; GO:0071474 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P52135 YFJT_ECOLI Uncharacterized protein YfjT yfjT b2637 JW2618 yfjT 17,099 +P33355 YEHS_ECOLI Uncharacterized protein YehS yehS b2124 JW2112 yehS 17,973 +P31470 YIEK_ECOLI Uncharacterized protein YieK yieK b3718 JW5613 yieK 26,279 carbohydrate metabolic process [GO:0005975]; glucosamine catabolic process [GO:0006043]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glucosamine-6-phosphate deaminase activity [GO:0004342]; identical protein binding [GO:0042802]; carbohydrate metabolic process [GO:0005975]; glucosamine catabolic process [GO:0006043]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] glucosamine-6-phosphate deaminase activity [GO:0004342]; identical protein binding [GO:0042802] GO:0004342; GO:0005737; GO:0005829; GO:0005975; GO:0006043; GO:0006046; GO:0006048; GO:0019262; GO:0042802 +P0CF86 YFJU_ECOLI Putative arsenate reductase-like protein yfjU b2638 yfjU 11,824 response to arsenic-containing substance [GO:0046685] oxidoreductase activity [GO:0016491]; response to arsenic-containing substance [GO:0046685] oxidoreductase activity [GO:0016491] GO:0016491; GO:0046685 +P52131 YFJP_ECOLI Uncharacterized protein YfjP yfjP b2632 JW5419 yfjP 32,094 tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTP binding [GO:0005525]; tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] GTP binding [GO:0005525] GO:0002098; GO:0005525; GO:0005737; GO:0005829; GO:0030488 +P46136 YDDG_ECOLI Aromatic amino acid exporter YddG yddG b1473 JW1469 yddG 31,539 amino acid export across plasma membrane [GO:0032973] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; amino acid transmembrane transporter activity [GO:0015171]; aromatic amino acid transmembrane transporter activity [GO:0015173]; amino acid export across plasma membrane [GO:0032973] amino acid transmembrane transporter activity [GO:0015171]; aromatic amino acid transmembrane transporter activity [GO:0015173] GO:0005887; GO:0015171; GO:0015173; GO:0032973 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:21042032}; Multi-pass membrane protein {ECO:0000269|PubMed:21042032}. +P0ADP0 YIGB_ECOLI 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB (EC 3.1.3.104) yigB b3812 JW3785 yigB 27,122 dormancy process [GO:0022611]; riboflavin biosynthetic process [GO:0009231] 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity [GO:0043726]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; dormancy process [GO:0022611]; riboflavin biosynthetic process [GO:0009231] 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity [GO:0043726]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791] GO:0000287; GO:0009231; GO:0016791; GO:0022611; GO:0043726 +P76359 YEEP_ECOLI Putative uncharacterized protein YeeP yeeP b1999 JW5327 yeeP 27,074 +P39173 YEAD_ECOLI Putative glucose-6-phosphate 1-epimerase (EC 5.1.3.15) (Putative D-hexose-6-phosphate mutarotase) (Unknown protein from 2D-page spots T26/PR37) yeaD yzzQ b1780 JW1769 yzzQ yeaD 32,666 carbohydrate metabolic process [GO:0005975]; cellular response to DNA damage stimulus [GO:0006974] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; carbohydrate binding [GO:0030246]; glucose-6-phosphate 1-epimerase activity [GO:0047938]; carbohydrate metabolic process [GO:0005975]; cellular response to DNA damage stimulus [GO:0006974] carbohydrate binding [GO:0030246]; glucose-6-phosphate 1-epimerase activity [GO:0047938] GO:0005737; GO:0005829; GO:0005975; GO:0006974; GO:0030246; GO:0047938 +P46855 YHHZ_ECOLI Uncharacterized protein YhhZ yhhZ b3442 JW3406 yhhZ 44,231 +P0DP21 YJIP_ECOLI Putative inactive recombination-promoting nuclease-like protein YjiP yjiP rpnD b4338 JW5953 rpnD yjiP 12,078 +P36680 ZAPD_ECOLI Cell division protein ZapD (Z ring-associated protein D) zapD yacF b0102 JW0099 yacF zapD 28,292 division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093] cell division site [GO:0032153]; cytosol [GO:0005829] cell division site [GO:0032153]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093] identical protein binding [GO:0042802] GO:0000917; GO:0005829; GO:0032153; GO:0042802; GO:0043093 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01092, ECO:0000269|PubMed:22505682}. Note=Localizes to mid-cell in an FtsZ-dependent manner. Localization does not require FtsA, ZipA, ZapA or ZapC. +P75862 ZAPC_ECOLI Cell division protein ZapC (FtsZ-associated protein C) (Z-ring-associated protein C) zapC ycbW b0946 JW5125 ycbW zapC 20,589 contractile ring maintenance [GO:0036212]; division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093]; regulation of cell division [GO:0051302] cell division site [GO:0032153]; cytoplasm [GO:0005737] cell division site [GO:0032153]; cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; contractile ring maintenance [GO:0036212]; division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093]; regulation of cell division [GO:0051302] identical protein binding [GO:0042802] GO:0000917; GO:0005737; GO:0032153; GO:0036212; GO:0042802; GO:0043093; GO:0051302 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00906, ECO:0000269|PubMed:21216995, ECO:0000269|PubMed:21216997}. Note=Colocalizes with FtsZ at division sites. Localization to the Z ring is dependent on FtsZ and independent of FtsA, ZipA, ZapA or ZapB. +P67338 YOAH_ECOLI UPF0181 protein YoaH yoaH b1811 JW1800 yoaH 6,554 +P0AE42 YQAE_ECOLI UPF0057 membrane protein YqaE yqaE b2666 JW2641 yqaE 5,865 response to antibiotic [GO:0046677] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; response to antibiotic [GO:0046677] GO:0005886; GO:0016021; GO:0046677 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +A5A618 YNHF_ECOLI Uncharacterized protein YnhF ynhF b4602 JW1649.1 ynhF 2,998 cellular response to hypoxia [GO:0071456] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cellular response to hypoxia [GO:0071456] GO:0005886; GO:0016020; GO:0016021; GO:0071456 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:19121005, ECO:0000305|PubMed:21778229}; Single-pass membrane protein {ECO:0000269|PubMed:19121005, ECO:0000269|PubMed:21778229}. Note=May be able to insert into the membrane in both orientations. +Q46939 YQEF_ECOLI Probable acetyl-CoA acetyltransferase (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) yqeF b2844 JW5453 yqeF 41,019 1-butanol biosynthetic process [GO:0071271]; fatty acid beta-oxidation [GO:0006635] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; acetyl-CoA C-acyltransferase activity [GO:0003988]; 1-butanol biosynthetic process [GO:0071271]; fatty acid beta-oxidation [GO:0006635] acetyl-CoA C-acetyltransferase activity [GO:0003985]; acetyl-CoA C-acyltransferase activity [GO:0003988] GO:0003985; GO:0003988; GO:0005737; GO:0006635; GO:0071271 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P76193 YNHG_ECOLI Probable L,D-transpeptidase YnhG (EC 2.-.-.-) ynhG b1678 JW1668 ynhG 36,082 cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan-protein cross-linking [GO:0018104]; regulation of cell shape [GO:0008360] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; peptidoglycan L,D-transpeptidase activity [GO:0071972]; transferase activity, transferring glycosyl groups [GO:0016757]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan-protein cross-linking [GO:0018104]; regulation of cell shape [GO:0008360] peptidoglycan L,D-transpeptidase activity [GO:0071972]; transferase activity, transferring glycosyl groups [GO:0016757] GO:0008360; GO:0009252; GO:0016757; GO:0018104; GO:0042597; GO:0071555; GO:0071972 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P0DPC9 YNFQ_ECOLI Protein YnfQ ynfQ b4724 ynfQ 7,141 +P64448 YNBE_ECOLI Uncharacterized protein YnbE ynbE b1382 JW1377 ynbE 6,840 +P76146 YNEE_ECOLI UPF0187 protein YneE yneE b1520 JW5245 yneE 34,809 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; chloride channel activity [GO:0005254] chloride channel activity [GO:0005254] GO:0005254; GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P64459 YNCJ_ECOLI Uncharacterized protein YncJ yncJ b1436 JW1432 yncJ 8,709 +P0A8M0 SYN_ECOLI Asparagine--tRNA ligase (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS) asnS tss b0930 JW0913 tss asnS 52,570 asparaginyl-tRNA aminoacylation [GO:0006421]; tRNA aminoacylation for protein translation [GO:0006418] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; asparagine-tRNA ligase activity [GO:0004816]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676]; asparaginyl-tRNA aminoacylation [GO:0006421]; tRNA aminoacylation for protein translation [GO:0006418] asparagine-tRNA ligase activity [GO:0004816]; ATP binding [GO:0005524]; nucleic acid binding [GO:0003676] GO:0003676; GO:0004816; GO:0005524; GO:0005737; GO:0006418; GO:0006421 SUBCELLULAR LOCATION: Cytoplasm. +P0AGG2 TESB_ECOLI Acyl-CoA thioesterase 2 (EC 3.1.2.20) (Thioesterase II) (TEII) tesB b0452 JW0442 tesB 31,966 acyl-CoA metabolic process [GO:0006637]; fatty acid catabolic process [GO:0009062] cytosol [GO:0005829] cytosol [GO:0005829]; acyl-CoA hydrolase activity [GO:0047617]; identical protein binding [GO:0042802]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290]; acyl-CoA metabolic process [GO:0006637]; fatty acid catabolic process [GO:0009062] acyl-CoA hydrolase activity [GO:0047617]; identical protein binding [GO:0042802]; myristoyl-CoA hydrolase activity [GO:0102991]; palmitoyl-CoA hydrolase activity [GO:0016290] GO:0005829; GO:0006637; GO:0009062; GO:0016290; GO:0042802; GO:0047617; GO:0102991 +P77529 TCYP_ECOLI L-cystine transporter TcyP (S-sulfocysteine transporter) tcyP ydjN b1729 JW1718 ydjN tcyP 48,662 L-cystine transport [GO:0015811]; sulfur amino acid transport [GO:0000101]; sulfur utilization [GO:0006791] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; L-cystine transmembrane transporter activity [GO:0015184]; sulfur amino acid transmembrane transporter activity [GO:0000099]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857]; L-cystine transport [GO:0015811]; sulfur amino acid transport [GO:0000101]; sulfur utilization [GO:0006791] L-cystine transmembrane transporter activity [GO:0015184]; sulfur amino acid transmembrane transporter activity [GO:0000099]; symporter activity [GO:0015293]; transmembrane transporter activity [GO:0022857] GO:0000099; GO:0000101; GO:0005886; GO:0006791; GO:0015184; GO:0015293; GO:0015811; GO:0016020; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +Q47537 TAUA_ECOLI Taurine-binding periplasmic protein (Sulfate starvation-induced protein 1) (SSI1) tauA ssiA yaiR b0365 JW0357 ssiA yaiR tauA 34,266 alkanesulfonate transport [GO:0042918]; cellular response to sulfate starvation [GO:0009970]; sulfur compound metabolic process [GO:0006790]; taurine transport [GO:0015734] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288]; alkanesulfonate transmembrane transporter activity [GO:0042959]; transmembrane transporter activity [GO:0022857]; alkanesulfonate transport [GO:0042918]; cellular response to sulfate starvation [GO:0009970]; sulfur compound metabolic process [GO:0006790]; taurine transport [GO:0015734] alkanesulfonate transmembrane transporter activity [GO:0042959]; transmembrane transporter activity [GO:0022857] GO:0006790; GO:0009970; GO:0015734; GO:0022857; GO:0030288; GO:0042918; GO:0042959; GO:0043190 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P05719 T1SK_ECOLI Type-1 restriction enzyme EcoKI specificity protein (S.EcoKI) (Type I restriction enzyme EcoKI specificity protein) (S protein) hsdS hss b4348 JW4311 hss hsdS 51,395 DNA restriction-modification system [GO:0009307] DNA binding [GO:0003677]; DNA restriction-modification system [GO:0009307] DNA binding [GO:0003677] GO:0003677; GO:0009307 +P36662 TORD_ECOLI Chaperone protein TorD torD b0998 JW0983 torD 22,574 protein complex oligomerization [GO:0051259]; protein folding [GO:0006457]; protein maturation [GO:0051604] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; identical protein binding [GO:0042802]; molybdopterin cofactor binding [GO:0043546]; peptide binding [GO:0042277]; protein complex oligomerization [GO:0051259]; protein folding [GO:0006457]; protein maturation [GO:0051604] identical protein binding [GO:0042802]; molybdopterin cofactor binding [GO:0043546]; peptide binding [GO:0042277] GO:0005737; GO:0006457; GO:0042277; GO:0042802; GO:0043546; GO:0051259; GO:0051604 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9632735}. +P45475 UBIV_ECOLI Ubiquinone biosynthesis protein UbiV ubiV yhbV b3159 JW5530 yhbV ubiV 32,535 ubiquinone biosynthetic process from chorismate [GO:0032150] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; ubiquinone biosynthetic process from chorismate [GO:0032150] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0032150; GO:0046872; GO:0051539 +P10908 UGPQ_ECOLI Glycerophosphodiester phosphodiesterase, cytoplasmic (Glycerophosphoryl diester phosphodiesterase, cytoplasmic) (EC 3.1.4.46) ugpQ b3449 JW3414 ugpQ 27,410 glycerol metabolic process [GO:0006071]; lipid metabolic process [GO:0006629] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; glycerophosphocholine phosphodiesterase activity [GO:0047389]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; glycerophosphoinositol glycerophosphodiesterase activity [GO:0047395]; magnesium ion binding [GO:0000287]; glycerol metabolic process [GO:0006071]; lipid metabolic process [GO:0006629] glycerophosphocholine phosphodiesterase activity [GO:0047389]; glycerophosphodiester phosphodiesterase activity [GO:0008889]; glycerophosphoinositol glycerophosphodiesterase activity [GO:0047395]; magnesium ion binding [GO:0000287] GO:0000287; GO:0005737; GO:0006071; GO:0006629; GO:0008889; GO:0047389; GO:0047395 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18083802}. +P27835 WZYE_ECOLI Probable ECA polymerase wzyE wzy b3793 JW3769 wzy wzyE 51,517 enterobacterial common antigen biosynthetic process [GO:0009246] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; enterobacterial common antigen biosynthetic process [GO:0009246] GO:0005886; GO:0005887; GO:0009246 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01003, ECO:0000305}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01003}. +P71238 WCAD_ECOLI Putative colanic acid polymerase wcaD b2056 JW2041 wcaD 45,409 colanic acid metabolic process [GO:0046377]; lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; colanic acid metabolic process [GO:0046377]; lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] GO:0005886; GO:0009103; GO:0016021; GO:0045228; GO:0046377 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0DSE7 YBIE_ECOLI Protein YbiE ybiE b4769 ybiE 2,006 +Q2EEQ3 YAHH_ECOLI Putative uncharacterized protein YahH yahH b0322 JW5893 yahH 10,634 +P30149 YABI_ECOLI Inner membrane protein YabI yabI b0065 JW5005 yabI 28,244 FtsZ-dependent cytokinesis [GO:0043093]; response to ionizing radiation [GO:0010212] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; FtsZ-dependent cytokinesis [GO:0043093]; response to ionizing radiation [GO:0010212] GO:0005886; GO:0010212; GO:0016021; GO:0043093 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P71311 YAIS_ECOLI Uncharacterized deacetylase YaiS (EC 3.-.-.-) yaiS b0364 JW0356 yaiS 20,487 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811] GO:0016811 +P0AD53 YGAC_ECOLI Uncharacterized protein YgaC ygaC b2671 JW2646 ygaC 13,066 +P76406 YEGR_ECOLI Uncharacterized protein YegR yegR b2085 JW5837 yegR 11,465 +P0DSG1 YFIS_ECOLI Protein YfiS yfiS b4783 yfiS 2,162 +Q46905 YGCO_ECOLI Ferredoxin-like protein YgcO ygcO b2767 JW2737 ygcO 9,662 DNA mediated transformation [GO:0009294] iron ion binding [GO:0005506]; iron-sulfur cluster binding [GO:0051536]; DNA mediated transformation [GO:0009294] iron ion binding [GO:0005506]; iron-sulfur cluster binding [GO:0051536] GO:0005506; GO:0009294; GO:0051536 +P65292 YGDI_ECOLI Uncharacterized lipoprotein YgdI ygdI b2809 JW5448 ygdI 8,174 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P39353 YJHC_ECOLI Uncharacterized oxidoreductase YjhC (EC 1.-.-.-) yjhC b4280 JW5769 yjhC 41,384 cellular response to DNA damage stimulus [GO:0006974] nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491]; cellular response to DNA damage stimulus [GO:0006974] nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491] GO:0000166; GO:0006974; GO:0016491 +P32051 YDEK_ECOLI Uncharacterized lipoprotein YdeK (ORFT) ydeK orfT b1510 JW1503 orfT ydeK 136,515 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P0AD03 YEBS_ECOLI Intermembrane transport protein YebS yebS b1833 JW1822 yebS 48,273 response to heat [GO:0009408] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; response to heat [GO:0009408] GO:0005886; GO:0005887; GO:0009408 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:27795327}; Multi-pass membrane protein {ECO:0000269|PubMed:27795327}. +P76219 YDJX_ECOLI TVP38/TMEM64 family membrane protein YdjX ydjX b1750 JW1739 ydjX 26,058 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0AF43 YJBB_ECOLI Uncharacterized protein YjbB yjbB b4020 JW3980 yjbB 59,467 phosphate ion transmembrane transport [GO:0035435]; sodium-dependent phosphate transport [GO:0044341] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; inorganic phosphate transmembrane transporter activity [GO:0005315]; sodium:phosphate symporter activity [GO:0005436]; phosphate ion transmembrane transport [GO:0035435]; sodium-dependent phosphate transport [GO:0044341] inorganic phosphate transmembrane transporter activity [GO:0005315]; sodium:phosphate symporter activity [GO:0005436] GO:0005315; GO:0005436; GO:0005886; GO:0016021; GO:0035435; GO:0044341 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P32108 YIBI_ECOLI Uncharacterized protein YibI yibI b3598 JW3572 yibI 13,866 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 +P32687 YJBF_ECOLI Uncharacterized lipoprotein YjbF yjbF b4027 JW5711 yjbF 23,755 extracellular polysaccharide biosynthetic process [GO:0045226] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; extracellular polysaccharide biosynthetic process [GO:0045226] GO:0005886; GO:0045226 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P45549 YHFW_ECOLI Uncharacterized protein YhfW yhfW b3380 JW3343 yhfW 44,560 cellular metabolic compound salvage [GO:0043094]; nucleotide metabolic process [GO:0009117] cytosol [GO:0005829] cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; phosphopentomutase activity [GO:0008973]; cellular metabolic compound salvage [GO:0043094]; nucleotide metabolic process [GO:0009117] magnesium ion binding [GO:0000287]; phosphopentomutase activity [GO:0008973] GO:0000287; GO:0005829; GO:0008973; GO:0009117; GO:0043094 +P0AFJ1 YJDM_ECOLI Protein YjdM yjdM phnA b4108 JW4069 phnA yjdM 12,345 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P39332 YJGH_ECOLI RutC family protein YjgH yjgH b4248 JW4206 yjgH 14,590 +P76090 YNBA_ECOLI Inner membrane protein YnbA ynbA b1408 JW1405 ynbA 22,524 phospholipid biosynthetic process [GO:0008654] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; phospholipid biosynthetic process [GO:0008654] phosphotransferase activity, for other substituted phosphate groups [GO:0016780] GO:0005886; GO:0008654; GO:0016021; GO:0016780 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0DSF2 YNCP_ECOLI Protein YncP yncP b4774 yncP 2,400 +P0A9X1 ZNUC_ECOLI Zinc import ATP-binding protein ZnuC (EC 7.2.2.20) znuC yebM b1858 JW1847 yebM znuC 27,867 response to zinc ion [GO:0010043] ATP-binding cassette (ABC) transporter complex [GO:0043190] ATP-binding cassette (ABC) transporter complex [GO:0043190]; ABC-type zinc transporter activity [GO:0015633]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626]; response to zinc ion [GO:0010043] ABC-type zinc transporter activity [GO:0015633]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0010043; GO:0015633; GO:0042626; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01725}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01725}. +P33226 TORC_ECOLI Cytochrome c-type protein TorC torC b0996 JW0981 torC 43,607 aerobic respiration [GO:0009060]; anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061]; negative regulation of signal transduction [GO:0009968] Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; iron ion binding [GO:0005506]; aerobic respiration [GO:0009060]; anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061]; negative regulation of signal transduction [GO:0009968] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; iron ion binding [GO:0005506] GO:0005506; GO:0005886; GO:0009055; GO:0009060; GO:0009061; GO:0009276; GO:0009968; GO:0016020; GO:0016021; GO:0019645; GO:0020037; GO:0030288 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass type II membrane protein. +P69822 ULAB_ECOLI Ascorbate-specific PTS system EIIB component (EC 2.7.1.194) (Ascorbate-specific phosphotransferase enzyme IIB component) ulaB sgaB yjfT b4194 JW4152 sgaB yjfT ulaB 10,896 L-ascorbic acid transmembrane transport [GO:0015882]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity [GO:0090585]; L-ascorbic acid transmembrane transport [GO:0015882]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity [GO:0090585] GO:0005737; GO:0008982; GO:0009401; GO:0015882; GO:0016301; GO:0090585 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P31434 XYLS_ECOLI Alpha-xylosidase (EC 3.2.1.177) yicI b3656 JW3631 yicI 88,079 carbohydrate metabolic process [GO:0005975] alpha-D-xyloside xylohydrolase [GO:0061634]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; xyloglucan 1,6-alpha-xylosidase activity [GO:0080176]; carbohydrate metabolic process [GO:0005975] alpha-D-xyloside xylohydrolase [GO:0061634]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; xyloglucan 1,6-alpha-xylosidase activity [GO:0080176] GO:0005975; GO:0030246; GO:0042802; GO:0061634; GO:0080176 +P77596 YAGF_ECOLI D-xylonate dehydratase YagF (EC 4.2.1.82) yagF b0269 JW0262 yagF 69,399 aldonic acid catabolic process [GO:0046176] cytosol [GO:0005829] cytosol [GO:0005829]; hydro-lyase activity [GO:0016836]; xylonate dehydratase activity [GO:0050401]; aldonic acid catabolic process [GO:0046176] hydro-lyase activity [GO:0016836]; xylonate dehydratase activity [GO:0050401] GO:0005829; GO:0016836; GO:0046176; GO:0050401 +P37443 YCAI_ECOLI Uncharacterized protein YcaI ycaI b0913 JW5120 ycaI 84,474 establishment of competence for transformation [GO:0030420] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; establishment of competence for transformation [GO:0030420] GO:0005886; GO:0016021; GO:0030420 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P77187 YAHF_ECOLI Uncharacterized protein YahF yahF b0320 JW0312 yahF 55,581 tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829]; succinate-CoA ligase complex (ADP-forming) [GO:0009361] cytosol [GO:0005829]; succinate-CoA ligase complex (ADP-forming) [GO:0009361]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]; succinate-CoA ligase (GDP-forming) activity [GO:0004776]; tricarboxylic acid cycle [GO:0006099] succinate-CoA ligase (ADP-forming) activity [GO:0004775]; succinate-CoA ligase (GDP-forming) activity [GO:0004776] GO:0004775; GO:0004776; GO:0005829; GO:0006099; GO:0009361 +P75916 YCDZ_ECOLI Inner membrane protein YcdZ ycdZ b1036 JW5147 ycdZ 17,074 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P39901 YBFI_ECOLI Putative uncharacterized protein YbfI ybfI b4636 b0691.1 ybfI 7,821 phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677] GO:0000160; GO:0003677; GO:0006355 +P77216 YBDN_ECOLI Uncharacterized protein YbdN ybdN b0602 JW0595 ybdN 47,827 catalytic activity [GO:0003824]; transcription regulatory region sequence-specific DNA binding [GO:0000976] catalytic activity [GO:0003824]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003824 +P27238 YFED_ECOLI Uncharacterized protein YfeD yfeD b2399 JW2394 yfeD 14,910 DNA binding [GO:0003677] DNA binding [GO:0003677] GO:0003677 +P76069 YDAY_ECOLI Protein YdaY ydaY b1366 JW1360 ydaY 13,473 +A5A612 YMGJ_ECOLI Uncharacterized protein YmgJ ymgJ b4594 ymgJ 7,362 +P77252 YKGE_ECOLI Uncharacterized protein YkgE ykgE b0306 JW5041 ykgE 26,004 cytosol [GO:0005829] cytosol [GO:0005829]; L-lactate dehydrogenase activity [GO:0004459] L-lactate dehydrogenase activity [GO:0004459] GO:0004459; GO:0005829 +P37675 YIAN_ECOLI 2,3-diketo-L-gulonate TRAP transporter large permease protein YiaN yiaN b3578 JW5651 yiaN 45,368 carbohydrate transmembrane transport [GO:0034219] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; carbohydrate transmembrane transporter activity [GO:0015144]; transmembrane transporter activity [GO:0022857]; carbohydrate transmembrane transport [GO:0034219] carbohydrate transmembrane transporter activity [GO:0015144]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0015144; GO:0016021; GO:0022857; GO:0034219 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P76278 YEBZ_ECOLI Inner membrane protein YebZ yebZ b1840 JW1829 yebZ 32,526 copper ion transport [GO:0006825] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; copper ion transport [GO:0006825] GO:0005886; GO:0006825; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0ADP9 YIHD_ECOLI Protein YihD yihD b3858 JW3830 yihD 10,273 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P31467 YIEH_ECOLI 6-phosphogluconate phosphatase (EC 3.1.3.-) yieH b3715 JW3693 yieH 24,664 magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; phosphatase activity [GO:0016791] magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; phosphatase activity [GO:0016791] GO:0000287; GO:0016791; GO:0030145 +P77692 YKFI_ECOLI Toxin YkfI ykfI b0245 JW0234 ykfI 12,905 negative regulation of cell growth [GO:0030308] negative regulation of cell growth [GO:0030308] GO:0030308 +P37673 YIAL_ECOLI Protein YiaL yiaL b3576 JW3548 yiaL 17,549 response to radiation [GO:0009314] cytosol [GO:0005829] cytosol [GO:0005829]; response to radiation [GO:0009314] GO:0005829; GO:0009314 +P32688 YJBG_ECOLI Uncharacterized protein YjbG yjbG b4028 JW3988 yjbG 26,281 extracellular polysaccharide biosynthetic process [GO:0045226] extracellular polysaccharide biosynthetic process [GO:0045226] GO:0045226 +P76585 YPHG_ECOLI Uncharacterized protein YphG yphG b2549 JW5405 yphG 123,832 cell division [GO:0051301] cell division [GO:0051301] GO:0051301 +P0AE48 YTFP_ECOLI Gamma-glutamylcyclotransferase family protein YtfP ytfP b4222 JW4181 ytfP 12,866 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +A0A385XJK5 YPAB_ECOLI Protein YpaB ypaB b4605 ypaB 5,325 +P0DPP1 YNFP_ECOLI Protein YnfP ynfP ydfJ_1 b4534 ydfJ_1 ynfP 4,039 +P39172 ZNUA_ECOLI High-affinity zinc uptake system protein ZnuA znuA yebL yzzP b1857 JW5831 yebL yzzP znuA 33,777 cell adhesion [GO:0007155]; zinc ion transport [GO:0006829] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; zinc ion binding [GO:0008270]; cell adhesion [GO:0007155]; zinc ion transport [GO:0006829] zinc ion binding [GO:0008270] GO:0006829; GO:0007155; GO:0008270; GO:0042597 SUBCELLULAR LOCATION: Periplasm. +P76150 YNEK_ECOLI Uncharacterized protein YneK yneK b1527 JW1520 yneK 42,841 +P0CE44 UIDB_ECOLI Glucuronide carrier protein homolog uidB gusB uidP b1616 JW1608 gusB uidP uidB 49,908 carbohydrate transport [GO:0008643]; organic substance transport [GO:0071702]; sodium ion transport [GO:0006814] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; symporter activity [GO:0015293]; carbohydrate transport [GO:0008643]; organic substance transport [GO:0071702]; sodium ion transport [GO:0006814] symporter activity [GO:0015293] GO:0005886; GO:0005887; GO:0006814; GO:0008643; GO:0015293; GO:0071702 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P30177 YBIB_ECOLI Uncharacterized protein YbiB ybiB b0800 JW0785 ybiB 35,049 tryptophan biosynthetic process [GO:0000162] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; transferase activity, transferring glycosyl groups [GO:0016757]; tryptophan biosynthetic process [GO:0000162] DNA binding [GO:0003677]; RNA binding [GO:0003723]; transferase activity, transferring glycosyl groups [GO:0016757] GO:0000162; GO:0003677; GO:0003723; GO:0005829; GO:0016757 +P43674 YCAL_ECOLI Metalloprotease YcaL (EC 3.4.-.-) ycaL b0909 JW0892 ycaL 26,740 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237] GO:0004222; GO:0005886; GO:0008237; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P37018 YADM_ECOLI Uncharacterized fimbrial-like protein YadM yadM b0138 JW0134 yadM 20,307 cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0007155; GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. +P77775 YFCH_ECOLI Epimerase family protein YfcH yfcH b2304 JW2301 yfcH 32,699 catalytic activity [GO:0003824] catalytic activity [GO:0003824] GO:0003824 +P37597 YDHC_ECOLI Inner membrane transport protein YdhC ydhC b1660 JW1652 ydhC 43,367 xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; xenobiotic transmembrane transporter activity [GO:0042910]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0016021; GO:0042910; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P45423 YHCG_ECOLI Putative nuclease YhcG (EC 3.1.-.-) yhcG b3220 JW3189 yhcG 43,293 DNA binding [GO:0003677]; nuclease activity [GO:0004518] DNA binding [GO:0003677]; nuclease activity [GO:0004518] GO:0003677; GO:0004518 +P42590 YGJI_ECOLI Inner membrane transporter YgjI ygjI b3078 JW5512 ygjI 52,147 amino acid transport [GO:0006865] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; amino acid transport [GO:0006865] amino acid transmembrane transporter activity [GO:0015171] GO:0005886; GO:0006865; GO:0015171; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P64474 YDHL_ECOLI Uncharacterized protein YdhL ydhL b1648 JW5827 ydhL 9,359 +P45505 YFAH_ECOLI Putative protein YfaH yfaH b2238 JW2232 yfaH 7,517 +P77714 YDIT_ECOLI Ferredoxin-like protein YdiT ydiT b1700 JW1690 ydiT 10,724 iron ion binding [GO:0005506]; iron-sulfur cluster binding [GO:0051536] iron ion binding [GO:0005506]; iron-sulfur cluster binding [GO:0051536] GO:0005506; GO:0051536 +P75962 YMFA_ECOLI Inner membrane protein YmfA ymfA b1122 JW5164 ymfA 17,416 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P52126 YFJK_ECOLI Uncharacterized protein YfjK yfjK b2627 JW2608 yfjK 83,062 defense response to virus [GO:0051607]; response to ionizing radiation [GO:0010212] defense response to virus [GO:0051607]; response to ionizing radiation [GO:0010212] GO:0010212; GO:0051607 +P0DPO2 YMJE_ECOLI Protein YmjE ymjE b4742 ymjE 5,971 +P77730 YDCR_ECOLI Uncharacterized HTH-type transcriptional regulator YdcR ydcR b1439 JW1434 ydcR 52,793 alpha-amino acid metabolic process [GO:1901605]; biosynthetic process [GO:0009058] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483]; alpha-amino acid metabolic process [GO:1901605]; biosynthetic process [GO:0009058] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; pyridoxal phosphate binding [GO:0030170]; transaminase activity [GO:0008483] GO:0003677; GO:0003700; GO:0008483; GO:0009058; GO:0030170; GO:1901605 +Q7DFV3 YMGG_ECOLI UPF0757 protein YmgG ymgG b1172 JW5178 ymgG 10,807 +Q47688 YKFC_ECOLI Protein YkfC ykfC b0258 JW5813 ykfC 43,739 +P0AA70 YEDA_ECOLI Uncharacterized inner membrane transporter YedA yedA b1959 JW1942 yedA 32,194 response to toxic substance [GO:0009636] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; response to toxic substance [GO:0009636] GO:0005887; GO:0009636 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76419 YEGV_ECOLI Uncharacterized sugar kinase YegV (EC 2.7.1.-) yegV b2100 JW2087 yegV 34,385 kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773] kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773] GO:0016301; GO:0016773 +P0A8A0 YEBC_ECOLI Probable transcriptional regulatory protein YebC yebC b1864 JW1853 yebC 26,423 regulation of transcription, DNA-templated [GO:0006355]; response to ionizing radiation [GO:0010212] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; regulation of transcription, DNA-templated [GO:0006355]; response to ionizing radiation [GO:0010212] DNA binding [GO:0003677] GO:0003677; GO:0005829; GO:0006355; GO:0010212 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00693}. +C1P5Z9 YMIB_ECOLI Putative protein YmiB ymiB b4672 JW1278.1 ymiB 4,122 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021] GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P77433 YKGG_ECOLI Uncharacterized protein YkgG ykgG b0308 JW5042 ykgG 25,213 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P27840 YIGE_ECOLI Uncharacterized protein YigE yigE b4482 JW5591 yigE 27,908 +P76296 YECT_ECOLI Uncharacterized protein YecT yecT b1877 JW5310 yecT 18,885 +P32680 YJAG_ECOLI Uncharacterized protein YjaG yjaG b3999 JW3963 yjaG 22,613 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P76234 YEAE_ECOLI Uncharacterized protein YeaE yeaE b1781 JW1770 yeaE 30,987 methylglyoxal catabolic process [GO:0051596] D-threo-aldose 1-dehydrogenase activity [GO:0047834]; oxidoreductase activity [GO:0016491]; methylglyoxal catabolic process [GO:0051596] D-threo-aldose 1-dehydrogenase activity [GO:0047834]; oxidoreductase activity [GO:0016491] GO:0016491; GO:0047834; GO:0051596 +P37642 YHJD_ECOLI Inner membrane protein YhjD yhjD b3522 JW3490 yhjD 37,911 lipopolysaccharide transport [GO:0015920] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; lipopolysaccharide transport [GO:0015920] GO:0005886; GO:0005887; GO:0015920 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P28912 YHHI_ECOLI H repeat-associated putative transposase YhhI (ORF-H) yhhI b3484 JW3451 yhhI 43,146 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P11291 YZCX_ECOLI Protein YzcX (CyaX) (O161) yzcX cyaX b3808 JW3780 cyaX yzcX 17,342 cell outer membrane [GO:0009279] cell outer membrane [GO:0009279] GO:0009279 +Q46953 YPJF_ECOLI Toxin YpjF ypjF b2646 JW2627 ypjF 12,308 +P67553 YNFC_ECOLI UPF0257 lipoprotein YnfC ynfC b1585 JW5258 ynfC 26,507 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P76118 YNCH_ECOLI Uncharacterized protein YncH yncH b1455 JW5235 yncH 8,270 +P0DSG5 YQIM_ECOLI Protein YqiM yqiM b4787 yqiM 3,305 +P77087 TFAX_ECOLI Protein TfaX tfaX ylcE b0563 JW0552 ylcE tfaX 7,088 +P08956 T1RK_ECOLI Type I restriction enzyme EcoKI R protein (R.EcoKI) (EC 3.1.21.3) hsdR hsr b4350 JW4313 hsr hsdR 134,095 DNA restriction-modification system [GO:0009307]; viral process [GO:0016032] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; type I site-specific deoxyribonuclease activity [GO:0009035]; DNA restriction-modification system [GO:0009307]; viral process [GO:0016032] ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; type I site-specific deoxyribonuclease activity [GO:0009035] GO:0003677; GO:0004386; GO:0005524; GO:0005829; GO:0009035; GO:0009307; GO:0016032 +P30139 THIG_ECOLI Thiazole synthase (EC 2.8.1.10) thiG b3991 JW5549 thiG 26,896 thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] cytosol [GO:0005829] cytosol [GO:0005829]; thiazole synthase activity [GO:1990107]; thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229] thiazole synthase activity [GO:1990107] GO:0005829; GO:0009228; GO:0009229; GO:1990107 SUBCELLULAR LOCATION: Cytoplasm. +P42630 TDCG_ECOLI L-serine dehydratase TdcG (SDH) (EC 4.3.1.17) (L-serine deaminase) tdcG yhaP yhaQ b4471 JW5520 yhaP yhaQ tdcG 48,522 cellular amino acid catabolic process [GO:0009063]; gluconeogenesis [GO:0006094]; L-threonine catabolic process to propionate [GO:0070689] 4 iron, 4 sulfur cluster binding [GO:0051539]; L-serine ammonia-lyase activity [GO:0003941]; metal ion binding [GO:0046872]; cellular amino acid catabolic process [GO:0009063]; gluconeogenesis [GO:0006094]; L-threonine catabolic process to propionate [GO:0070689] 4 iron, 4 sulfur cluster binding [GO:0051539]; L-serine ammonia-lyase activity [GO:0003941]; metal ion binding [GO:0046872] GO:0003941; GO:0006094; GO:0009063; GO:0046872; GO:0051539; GO:0070689 +P0ABV6 TOLR_ECOLI Tol-Pal system protein TolR tolR b0738 JW0728 tolR 15,383 bacteriocin transport [GO:0043213]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein transport [GO:0015031] cell division site [GO:0032153]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cell division site [GO:0032153]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; bacteriocin transport [GO:0043213]; cell cycle [GO:0007049]; cell division [GO:0051301]; protein transport [GO:0015031] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0007049; GO:0015031; GO:0016021; GO:0022857; GO:0032153; GO:0043213; GO:0051301 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02203, ECO:0000269|PubMed:8331075, ECO:0000269|PubMed:8376353}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02203, ECO:0000269|PubMed:8376353, ECO:0000305|PubMed:8331075}. Note=Accumulates at cell constriction sites. Recruitment to the division site is dependent on FtsN activity. {ECO:0000269|PubMed:17233825}. +P37387 XYLF_ECOLI D-xylose-binding periplasmic protein xylF xylT b3566 JW3538 xylT xylF 35,734 D-xylose metabolic process [GO:0042732]; D-xylose transmembrane transport [GO:0015753] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; carbohydrate binding [GO:0030246]; monosaccharide binding [GO:0048029]; D-xylose metabolic process [GO:0042732]; D-xylose transmembrane transport [GO:0015753] carbohydrate binding [GO:0030246]; monosaccharide binding [GO:0048029] GO:0015753; GO:0030246; GO:0030288; GO:0042732; GO:0048029 SUBCELLULAR LOCATION: Periplasm. +P00944 XYLA_ECOLI Xylose isomerase (EC 5.3.1.5) (D-xylulose keto-isomerase) xylA b3565 JW3537 xylA 49,742 D-xylose catabolic process [GO:0042843] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; magnesium ion binding [GO:0000287]; xylose isomerase activity [GO:0009045]; D-xylose catabolic process [GO:0042843] magnesium ion binding [GO:0000287]; xylose isomerase activity [GO:0009045] GO:0000287; GO:0005737; GO:0009045; GO:0042843 SUBCELLULAR LOCATION: Cytoplasm. +P0A8P6 XERC_ECOLI Tyrosine recombinase XerC xerC b3811 JW3784 xerC 33,868 cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; plasmid maintenance [GO:0006276]; plasmid recombination [GO:0042150]; resolution of recombination intermediates [GO:0071139]; transposition, DNA-mediated [GO:0006313] cytoplasm [GO:0005737]; Holliday junction resolvase complex [GO:0048476] cytoplasm [GO:0005737]; Holliday junction resolvase complex [GO:0048476]; DNA binding [GO:0003677]; site-specific recombinase activity [GO:0009009]; tyrosine-based site-specific recombinase activity [GO:0009037]; cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; plasmid maintenance [GO:0006276]; plasmid recombination [GO:0042150]; resolution of recombination intermediates [GO:0071139]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; site-specific recombinase activity [GO:0009009]; tyrosine-based site-specific recombinase activity [GO:0009037] GO:0003677; GO:0005737; GO:0006276; GO:0006313; GO:0007049; GO:0007059; GO:0009009; GO:0009037; GO:0042150; GO:0048476; GO:0051301; GO:0071139 SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with DNA. +P75970 VXIS_ECOLI Prophage excisionase-like protein (Excisionase-like protein from lambdoid prophage 14) xisE vxis ymfG b1141 JW1127 vxis ymfG xisE 9,287 DNA recombination [GO:0006310] DNA binding [GO:0003677]; DNA recombination [GO:0006310] DNA binding [GO:0003677] GO:0003677; GO:0006310 +P71242 WCAK_ECOLI Colanic acid biosynthesis protein WcaK (EC 2.-.-.-) wcaK b2045 JW2030 wcaK 47,344 lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] transferase activity [GO:0016740]; lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] transferase activity [GO:0016740] GO:0009103; GO:0016740; GO:0045228 +P0AB28 YCED_ECOLI Large ribosomal RNA subunit accumulation protein YceD (23S rRNA accumulation protein YceD) (G30K) yceD g30k b1088 JW1074 g30k yceD 19,315 ribosome biogenesis [GO:0042254] cytosol [GO:0005829] cytosol [GO:0005829]; ribosome biogenesis [GO:0042254] GO:0005829; GO:0042254 +P75697 YAIX_ECOLI Putative uncharacterized acetyltransferase YaiX (EC 2.3.1.-) yaiX yaiF b4579 JW0350/JW5814 b0359 b0362 yaiF yaiX 24,932 transferase activity, transferring acyl groups [GO:0016746] transferase activity, transferring acyl groups [GO:0016746] GO:0016746 +P77717 YBAY_ECOLI Uncharacterized lipoprotein YbaY ybaY b0453 JW0443 ybaY 19,431 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P0ADE8 YGFZ_ECOLI tRNA-modifying protein YgfZ ygfZ yzzW b2898 JW2866 yzzW ygfZ 36,094 iron-sulfur cluster assembly [GO:0016226]; RNA modification [GO:0009451]; tRNA processing [GO:0008033] cytosol [GO:0005829] cytosol [GO:0005829]; folic acid binding [GO:0005542]; iron-sulfur cluster assembly [GO:0016226]; RNA modification [GO:0009451]; tRNA processing [GO:0008033] folic acid binding [GO:0005542] GO:0005542; GO:0005829; GO:0008033; GO:0009451; GO:0016226 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P77688 YLBG_ECOLI Protein YlbG ylbG b0502 JW5880 ylbG 13,916 +P31449 YIDL_ECOLI Uncharacterized HTH-type transcriptional regulator YidL yidL b3680 JW3656 yidL 33,958 DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0043565 +P45424 YHCH_ECOLI Uncharacterized protein YhcH yhcH b3221 JW3190 yhcH 17,038 cellular response to DNA damage stimulus [GO:0006974] cytosol [GO:0005829] cytosol [GO:0005829]; cellular response to DNA damage stimulus [GO:0006974] GO:0005829; GO:0006974 +P52124 YFJI_ECOLI Protein YfjI yfjI b2625 JW2605 yfjI 54,027 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P45768 YHDY_ECOLI Inner membrane amino-acid ABC transporter permease protein YhdY yhdY b3270 JW5545 yhdY 41,484 amino acid transport [GO:0006865] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; amino acid transport [GO:0006865] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0006865; GO:0022857; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0DPN7 YMDG_ECOLI Protein YmdG ymdG b4737 ymdG 915 +P64506 YEBY_ECOLI Uncharacterized protein YebY yebY b1839 JW1828 yebY 12,378 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P33219 YEBF_ECOLI Protein YebF yebF b1847 JW1836 yebF 12,962 extracellular region [GO:0005576] extracellular region [GO:0005576] GO:0005576 SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16369539}. +P0ADL3 YICN_ECOLI Uncharacterized protein YicN yicN b3663 JW5637 yicN 17,219 +P39356 YJHU_ECOLI Uncharacterized transcriptional regulator YjhU yjhU b4295 JW5952 yjhU 36,112 cytosol [GO:0005829] cytosol [GO:0005829]; carbohydrate binding [GO:0030246]; DNA binding [GO:0003677] carbohydrate binding [GO:0030246]; DNA binding [GO:0003677] GO:0003677; GO:0005829; GO:0030246 +P32690 YJBI_ECOLI Putative protein YjbI yjbI b4038 JW3998 yjbI 51,708 +P64521 YEET_ECOLI Uncharacterized protein YeeT yeeT b2003 JW1985 yeeT 8,411 +P0AF82 YJFN_ECOLI Uncharacterized protein YjfN yjfN b4188 JW5742 yjfN 9,949 periplasmic space [GO:0042597] periplasmic space [GO:0042597]; endopeptidase activator activity [GO:0061133] endopeptidase activator activity [GO:0061133] GO:0042597; GO:0061133 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P0ADQ5 YIIE_ECOLI Uncharacterized protein YiiE yiiE b3889 JW5929 yiiE 8,408 regulation of transcription, DNA-templated [GO:0006355] regulation of transcription, DNA-templated [GO:0006355] GO:0006355 +P0ACY3 YEAG_ECOLI Uncharacterized protein YeaG yeaG b1783 JW1772 yeaG 74,480 cellular response to nitrogen starvation [GO:0006995] protein kinase activity [GO:0004672]; cellular response to nitrogen starvation [GO:0006995] protein kinase activity [GO:0004672] GO:0004672; GO:0006995 +P76138 YNEL_ECOLI Putative HTH-type transcriptional regulator YneL yneL b1506 JW5244 yneL 6,880 DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0043565 +P0AAD8 TDCC_ECOLI Threonine/serine transporter TdcC (H(+)/threonine-serine symporter) tdcC b3116 JW3087 tdcC 48,879 amino acid transport [GO:0006865]; L-serine transport [GO:0015825]; threonine transport [GO:0015826] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; L-serine transmembrane transporter activity [GO:0015194]; L-threonine transmembrane transporter activity [GO:0015195]; solute:proton symporter activity [GO:0015295]; threonine efflux transmembrane transporter activity [GO:0015565]; amino acid transport [GO:0006865]; L-serine transport [GO:0015825]; threonine transport [GO:0015826] L-serine transmembrane transporter activity [GO:0015194]; L-threonine transmembrane transporter activity [GO:0015195]; solute:proton symporter activity [GO:0015295]; threonine efflux transmembrane transporter activity [GO:0015565] GO:0005886; GO:0005887; GO:0006865; GO:0015194; GO:0015195; GO:0015295; GO:0015565; GO:0015825; GO:0015826; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01583, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01583, ECO:0000269|PubMed:15919996}. +P39414 TTDT_ECOLI L-tartrate/succinate antiporter (Tartrate carrier) (Tartrate transporter) ttdT ygjC ygjE b3063 JW3035 ygjC ygjE ttdT 52,906 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297] antiporter activity [GO:0015297] GO:0005886; GO:0015297; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A8F0 UPP_ECOLI Uracil phosphoribosyltransferase (EC 2.4.2.9) (UMP pyrophosphorylase) (UPRTase) upp uraP b2498 JW2483 uraP upp 22,533 nucleoside metabolic process [GO:0009116]; UMP salvage [GO:0044206]; uracil salvage [GO:0006223] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; uracil phosphoribosyltransferase activity [GO:0004845]; nucleoside metabolic process [GO:0009116]; UMP salvage [GO:0044206]; uracil salvage [GO:0006223] GTP binding [GO:0005525]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; uracil phosphoribosyltransferase activity [GO:0004845] GO:0000287; GO:0004845; GO:0005525; GO:0005737; GO:0005829; GO:0006223; GO:0009116; GO:0016020; GO:0042802; GO:0044206 +P60932 UPPP_ECOLI Undecaprenyl-diphosphatase (EC 3.6.1.27) (Bacitracin resistance protein) (Undecaprenyl pyrophosphate phosphatase) uppP bacA upk b3057 JW3029 bacA upk uppP 29,759 cell wall organization [GO:0071555]; dephosphorylation [GO:0016311]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; pyrophosphatase activity [GO:0016462]; undecaprenyl-diphosphatase activity [GO:0050380]; cell wall organization [GO:0071555]; dephosphorylation [GO:0016311]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] pyrophosphatase activity [GO:0016462]; undecaprenyl-diphosphatase activity [GO:0050380] GO:0005886; GO:0005887; GO:0008360; GO:0009252; GO:0016311; GO:0016462; GO:0046677; GO:0050380; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15138271, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15138271, ECO:0000269|PubMed:15919996}. +P0AAV6 YBGS_ECOLI Uncharacterized protein YbgS ybgS b0753 JW0736 ybgS 12,872 +P75783 YBIO_ECOLI Moderate conductance mechanosensitive channel YbiO ybiO b0808 JW5108 ybiO 81,904 cellular response to osmotic stress [GO:0071470] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; mechanosensitive ion channel activity [GO:0008381]; cellular response to osmotic stress [GO:0071470] mechanosensitive ion channel activity [GO:0008381] GO:0005886; GO:0008381; GO:0016021; GO:0071470 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:22874652}; Multi-pass membrane protein {ECO:0000269|PubMed:22874652}. +P60869 YBJL_ECOLI Putative transport protein YbjL ybjL b0847 JW0831 ybjL 60,351 potassium ion transport [GO:0006813] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cation transmembrane transporter activity [GO:0008324]; potassium ion transport [GO:0006813] cation transmembrane transporter activity [GO:0008324] GO:0005886; GO:0006813; GO:0008324; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01015}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01015}. +P0A8J4 YBED_ECOLI UPF0250 protein YbeD ybeD b0631 JW0626 ybeD 9,827 cellular response to heat [GO:0034605] cytosol [GO:0005829] cytosol [GO:0005829]; cellular response to heat [GO:0034605] GO:0005829; GO:0034605 +P76407 YEGS_ECOLI Lipid kinase YegS (EC 2.7.1.-) yegS b2086 JW2070 yegS 32,039 phospholipid biosynthetic process [GO:0008654] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; lipid kinase activity [GO:0001727]; magnesium ion binding [GO:0000287]; NAD+ kinase activity [GO:0003951]; phospholipid biosynthetic process [GO:0008654] ATP binding [GO:0005524]; lipid kinase activity [GO:0001727]; magnesium ion binding [GO:0000287]; NAD+ kinase activity [GO:0003951] GO:0000287; GO:0001727; GO:0003951; GO:0005524; GO:0005737; GO:0008654 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17351295}. +P03813 YGEA_ECOLI Broad specificity amino-acid racemase YgeA (EC 5.1.1.10) ygeA b2840 JW2808 ygeA 25,248 nitrogen compound metabolic process [GO:0006807] amino-acid racemase activity [GO:0047661]; nitrogen compound metabolic process [GO:0006807] amino-acid racemase activity [GO:0047661] GO:0006807; GO:0047661 +P33344 YEHE_ECOLI Uncharacterized protein YehE yehE b2112 JW2099 yehE 10,137 +P76616 YGAQ_ECOLI Putative uncharacterized protein YgaQ ygaQ ygaR yqaC yqaD b4462 JW2631/JW2633/JW5425/JW5426 b2654/b2657/b2658 ygaR yqaC yqaD ygaQ 85,227 carbohydrate metabolic process [GO:0005975] catalytic activity [GO:0003824]; carbohydrate metabolic process [GO:0005975] catalytic activity [GO:0003824] GO:0003824; GO:0005975 +P0DSF0 YMID_ECOLI Protein YmiD ymiD b4772 ymiD 4,937 +Q46863 YGIS_ECOLI Probable deoxycholate-binding periplasmic protein YgiS ygiS b3020 JW2988 ygiS 60,694 bile acid and bile salt transport [GO:0015721]; peptide transport [GO:0015833] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288] ATP-binding cassette (ABC) transporter complex [GO:0043190]; outer membrane-bounded periplasmic space [GO:0030288]; peptide transmembrane transporter activity [GO:1904680]; bile acid and bile salt transport [GO:0015721]; peptide transport [GO:0015833] peptide transmembrane transporter activity [GO:1904680] GO:0015721; GO:0015833; GO:0030288; GO:0043190; GO:1904680 SUBCELLULAR LOCATION: Periplasm {ECO:0000305|PubMed:25534751}. +P0ACW0 YDAF_ECOLI Uncharacterized protein YdaF ydaF b4527 JW1349 b1353.1 ydaF 5,769 +P25728 YGBA_ECOLI Uncharacterized protein YgbA ygbA b2732 JW2702 ygbA 13,940 +P64536 YEIS_ECOLI Uncharacterized protein YeiS yeiS b2145 JW5359 yeiS 9,264 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021] GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P0ADN2 YIFE_ECOLI UPF0438 protein YifE yifE b3764 JW3737 yifE 13,134 chromosome organization [GO:0051276]; chromosome segregation [GO:0007059] cytosol [GO:0005829] cytosol [GO:0005829]; chromosome organization [GO:0051276]; chromosome segregation [GO:0007059] GO:0005829; GO:0007059; GO:0051276 +P31471 YIEL_ECOLI Uncharacterized protein YieL yieL b3719 JW5612 yieL 42,755 carbohydrate metabolic process [GO:0005975] hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; carbohydrate metabolic process [GO:0005975] hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553] GO:0004553; GO:0005975 +P32129 YIHG_ECOLI Probable acyltransferase YihG (EC 2.3.-.-) yihG b3862 JW3834 yihG 36,289 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transferase activity, transferring acyl groups [GO:0016746] transferase activity, transferring acyl groups [GO:0016746] GO:0005886; GO:0016021; GO:0016746 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AB46 YMGD_ECOLI Uncharacterized protein YmgD ymgD b1171 JW5177 ymgD 11,852 outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288] GO:0030288 +P0AA31 YEDF_ECOLI Putative sulfur carrier protein YedF yedF b1930 JW1915 yedF 8,639 cellular response to DNA damage stimulus [GO:0006974] cellular response to DNA damage stimulus [GO:0006974] GO:0006974 +P31063 YEDD_ECOLI Uncharacterized lipoprotein YedD yedD b1928 JW1913 yedD 14,983 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P37681 YIAT_ECOLI Putative outer membrane protein YiaT yiaT b3584 JW3556 yiaT 27,414 peptidoglycan biosynthetic process [GO:0009252] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; protein-macromolecule adaptor activity [GO:0030674]; peptidoglycan biosynthetic process [GO:0009252] protein-macromolecule adaptor activity [GO:0030674] GO:0009252; GO:0009279; GO:0030674 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P0ABD1 YEAV_ECOLI Uncharacterized transporter YeaV yeaV b1801 JW5293 yeaV 52,881 nitrogen compound transport [GO:0071705] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; nitrogen compound transport [GO:0071705] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857; GO:0071705 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P39360 YJHI_ECOLI Uncharacterized HTH-type transcriptional regulator YjhI yjhI b4299 JW4261 yjhI 29,877 negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0045892 +P39337 YJGM_ECOLI Uncharacterized N-acetyltransferase YjgM (EC 2.3.1.-) yjgM b4256 JW5758 yjgM 18,622 N-acetyltransferase activity [GO:0008080] N-acetyltransferase activity [GO:0008080] GO:0008080 +P39298 YJFP_ECOLI Esterase YjfP (EC 3.1.-.-) yjfP b4190 JW4148 yjfP 27,588 hydrolase activity [GO:0016787]; serine-type peptidase activity [GO:0008236]; short-chain carboxylesterase activity [GO:0034338] hydrolase activity [GO:0016787]; serine-type peptidase activity [GO:0008236]; short-chain carboxylesterase activity [GO:0034338] GO:0008236; GO:0016787; GO:0034338 +P0ADX5 YHFG_ECOLI Uncharacterized protein YhfG yhfG b3362 JW3325 yhfG 6,599 +P0AF70 YJEI_ECOLI Uncharacterized protein YjeI yjeI b4144 JW5736 yjeI 11,958 cellular response to DNA damage stimulus [GO:0006974] cellular response to DNA damage stimulus [GO:0006974] GO:0006974 +P37772 YJFF_ECOLI Inner membrane ABC transporter permease protein YjfF yjfF b4231 JW5754 yjfF 34,978 carbohydrate transport [GO:0008643] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; carbohydrate transport [GO:0008643] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0008643; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P76001 YCGJ_ECOLI Uncharacterized protein YcgJ ycgJ b1177 JW1166 ycgJ 13,414 +P0ABU2 YCHF_ECOLI Ribosome-binding ATPase YchF ychF engD gtp1 b1203 JW1194 engD gtp1 ychF 39,667 response to oxidative stress [GO:0006979] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; enzyme inhibitor activity [GO:0004857]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022]; response to oxidative stress [GO:0006979] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; enzyme inhibitor activity [GO:0004857]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022] GO:0004857; GO:0005524; GO:0005525; GO:0005737; GO:0006979; GO:0016887; GO:0043022; GO:0043023; GO:0046872 +P76612 YPJB_ECOLI Protein YpjB ypjB b2649 JW2629 ypjB 29,787 +P45771 YRDD_ECOLI Uncharacterized protein YrdD yrdD b3283 JW5949 yrdD 19,871 DNA topological change [GO:0006265] chromosome [GO:0005694] chromosome [GO:0005694]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; iron ion binding [GO:0005506]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270]; DNA topological change [GO:0006265] DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; iron ion binding [GO:0005506]; single-stranded DNA binding [GO:0003697]; zinc ion binding [GO:0008270] GO:0003697; GO:0003917; GO:0005506; GO:0005694; GO:0006265; GO:0008270 +P64493 YOAF_ECOLI Uncharacterized protein YoaF yoaF b1793 JW1782 yoaF 8,942 +P0ADE2 YTFK_ECOLI Uncharacterized protein YtfK ytfK b4217 JW5749 ytfK 8,072 response to oxidative stress [GO:0006979] response to oxidative stress [GO:0006979] GO:0006979 +P0DN74 YTIA_ECOLI Uncharacterized protein YtiA ytiA b4715 ytiA 9,556 +C1P612 YQCG_ECOLI Uncharacterized protein YqcG yqcG b4682 JW2748.1 yqcG 5,383 cellular response to cell envelope stress [GO:0036460] cellular response to cell envelope stress [GO:0036460] GO:0036460 +C1P600 YNBG_ECOLI Uncharacterized protein YnbG ynbG b4674 JW1395.1 ynbG 2,657 +P0AFP9 YBHR_ECOLI Probable multidrug ABC transporter permease YbhR ybhR b0792 JW5803 ybhR 41,566 cellular response to DNA damage stimulus [GO:0006974]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; efflux transmembrane transporter activity [GO:0015562]; transmembrane transporter activity [GO:0022857]; cellular response to DNA damage stimulus [GO:0006974]; transmembrane transport [GO:0055085]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961] efflux transmembrane transporter activity [GO:0015562]; transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0006974; GO:0015562; GO:0022857; GO:0043190; GO:0055085; GO:1990961 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P0DSE6 YBGV_ECOLI Protein YbgV ybgV b4768 ybgV 1,172 +P30864 YAFC_ECOLI Uncharacterized HTH-type transcriptional regulator YafC yafC b0208 JW0198 yafC 33,776 regulation of transcription, DNA-templated [GO:0006355]; response to ionizing radiation [GO:0010212] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355]; response to ionizing radiation [GO:0010212] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355; GO:0010212 +P37008 YAGB_ECOLI Orphan antitoxin YagB yagB b0266 JW0259 yagB 13,184 positive regulation of cytoskeleton organization [GO:0051495] positive regulation of cytoskeleton organization [GO:0051495] GO:0051495 +P75829 YBJX_ECOLI Uncharacterized protein YbjX ybjX b0877 JW0861 ybjX 38,358 cellular response to DNA damage stimulus [GO:0006974] cellular response to DNA damage stimulus [GO:0006974] GO:0006974 +Q47536 YAIP_ECOLI Uncharacterized glycosyltransferase YaiP (EC 2.4.-.-) yaiP b0363 JW0355 yaiP 44,708 cellular response to DNA damage stimulus [GO:0006974] ligase activity [GO:0016874]; transferase activity, transferring glycosyl groups [GO:0016757]; cellular response to DNA damage stimulus [GO:0006974] ligase activity [GO:0016874]; transferase activity, transferring glycosyl groups [GO:0016757] GO:0006974; GO:0016757; GO:0016874 +P77806 YBDL_ECOLI Methionine aminotransferase (EC 2.6.1.88) (Methionine-oxo-acid transaminase) ybdL b0600 JW0593 ybdL 42,963 biosynthetic process [GO:0009058] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; kynurenine-oxoglutarate transaminase activity [GO:0016212]; methionine-oxo-acid transaminase activity [GO:0010326]; pyridoxal phosphate binding [GO:0030170]; biosynthetic process [GO:0009058] kynurenine-oxoglutarate transaminase activity [GO:0016212]; methionine-oxo-acid transaminase activity [GO:0010326]; pyridoxal phosphate binding [GO:0030170] GO:0005737; GO:0009058; GO:0010326; GO:0016212; GO:0030170 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P75711 YBBV_ECOLI Uncharacterized protein YbbV ybbV b0510 JW0498 ybbV 10,844 +P77174 YBDM_ECOLI Uncharacterized protein YbdM ybdM b0601 JW0594 ybdM 23,943 transcription regulatory region sequence-specific DNA binding [GO:0000976] transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976 +P76521 YFDY_ECOLI Uncharacterized protein YfdY yfdY b2377 JW2374 yfdY 8,874 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P37327 YFDC_ECOLI Inner membrane protein YfdC yfdC b2347 JW2344 yfdC 34,503 formate transport [GO:0015724] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; formate transmembrane transporter activity [GO:0015499]; formate transport [GO:0015724] formate transmembrane transporter activity [GO:0015499] GO:0005887; GO:0015499; GO:0015724 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A8D9 YFBV_ECOLI UPF0208 membrane protein YfbV yfbV b2295 JW2292 yfbV 17,213 negative regulation of chromosome organization [GO:2001251] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; negative regulation of chromosome organization [GO:2001251] GO:0005886; GO:0016021; GO:2001251 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77544 YFCF_ECOLI Glutathione S-transferase YfcF (EC 2.5.1.18) yfcF b2301 JW2298 yfcF 24,326 glutathione metabolic process [GO:0006749]; L-phenylalanine catabolic process [GO:0006559]; response to hydrogen peroxide [GO:0042542] glutathione transferase activity [GO:0004364]; maleylacetoacetate isomerase activity [GO:0016034]; peroxidase activity [GO:0004601]; glutathione metabolic process [GO:0006749]; L-phenylalanine catabolic process [GO:0006559]; response to hydrogen peroxide [GO:0042542] glutathione transferase activity [GO:0004364]; maleylacetoacetate isomerase activity [GO:0016034]; peroxidase activity [GO:0004601] GO:0004364; GO:0004601; GO:0006559; GO:0006749; GO:0016034; GO:0042542 +Q46795 YGEO_ECOLI Putative uncharacterized protein YgeO ygeO b2859 JW5846 ygeO 16,403 pathogenesis [GO:0009405] pathogenesis [GO:0009405] GO:0009405 +P76482 YFBL_ECOLI Uncharacterized protein YfbL yfbL b2271 JW2266 yfbL 35,931 proteolysis [GO:0006508] integral component of membrane [GO:0016021] integral component of membrane [GO:0016021]; metalloexopeptidase activity [GO:0008235]; proteolysis [GO:0006508] metalloexopeptidase activity [GO:0008235] GO:0006508; GO:0008235; GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +Q46908 YGCR_ECOLI Putative electron transfer flavoprotein subunit YgcR ygcR b2770 JW5441 ygcR 28,720 electron transfer activity [GO:0009055] electron transfer activity [GO:0009055] GO:0009055 +P0AFR7 YCJO_ECOLI Inner membrane ABC transporter permease protein YcjO ycjO b1311 JW1304 ycjO 33,225 transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transport [GO:0055085] GO:0005886; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76639 YGEH_ECOLI Uncharacterized protein YgeH ygeH b2852 JW2820 ygeH 52,753 phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677] GO:0000160; GO:0003677; GO:0005829; GO:0006355 +P33915 YEJE_ECOLI Inner membrane ABC transporter permease protein YejE yejE b2179 JW2167 yejE 38,092 microcin transport [GO:0042884]; oligopeptide transmembrane transport [GO:0035672] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; microcin transport [GO:0042884]; oligopeptide transmembrane transport [GO:0035672] GO:0005886; GO:0016021; GO:0035672; GO:0042884 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P33359 YEHW_ECOLI Glycine betaine uptake system permease protein YehW yehW b2128 JW2116 yehW 25,515 amino acid transport [GO:0006865]; glycine betaine transport [GO:0031460]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; amino acid transport [GO:0006865]; glycine betaine transport [GO:0031460]; transmembrane transport [GO:0055085] GO:0005886; GO:0006865; GO:0016021; GO:0031460; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P39342 YJGR_ECOLI Uncharacterized protein YjgR yjgR b4263 JW4220 yjgR 54,332 +P32136 YIHO_ECOLI Putative sulfoquinovose importer yihO b3876 JW5852 yihO 51,574 carbohydrate transport [GO:0008643]; organic substance transport [GO:0071702]; sodium ion transport [GO:0006814]; sulfur compound transport [GO:0072348] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; solute:cation symporter activity [GO:0015294]; sulfur compound transmembrane transporter activity [GO:1901682]; carbohydrate transport [GO:0008643]; organic substance transport [GO:0071702]; sodium ion transport [GO:0006814]; sulfur compound transport [GO:0072348] solute:cation symporter activity [GO:0015294]; sulfur compound transmembrane transporter activity [GO:1901682] GO:0005886; GO:0005887; GO:0006814; GO:0008643; GO:0015294; GO:0071702; GO:0072348; GO:1901682 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P31433 YICH_ECOLI AsmA family protein YicH yicH b3655 JW3630 yicH 62,272 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P46887 YECH_ECOLI Uncharacterized protein YecH yecH b1906 JW1894 yecH 8,629 +P39374 YJIC_ECOLI Uncharacterized protein YjiC yjiC b4325 JW4288 yjiC 30,593 +P0AF50 YJBR_ECOLI Uncharacterized protein YjbR yjbR b4057 JW4018 yjbR 13,519 +P39270 YJDF_ECOLI Inner membrane protein YjdF yjdF b4121 JW4082 yjdF 23,442 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A8M6 YEEX_ECOLI UPF0265 protein YeeX yeeX b2007 JW1989 yeeX 12,778 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P0ADC8 YJIX_ECOLI Uncharacterized protein YjiX yjiX b4353 JW4316 yjiX 7,729 cellular response to DNA damage stimulus [GO:0006974] cellular response to DNA damage stimulus [GO:0006974] GO:0006974 +P32167 YIIX_ECOLI Uncharacterized protein YiiX yiiX b3937 JW3908 yiiX 23,140 +P39283 YJEN_ECOLI Uncharacterized protein YjeN yjeN b4157 JW4118 yjeN 11,819 +P0AF73 YJET_ECOLI Uncharacterized protein YjeT yjeT b4176 JW4134 yjeT 7,166 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P75955 YCFT_ECOLI Inner membrane protein YcfT ycfT b1115 JW1101 ycfT 40,834 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] transferase activity, transferring acyl groups other than amino-acyl groups [GO:0016747] GO:0005886; GO:0016021; GO:0016747 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P39282 YJEM_ECOLI Inner membrane transporter YjeM yjeM b4156 JW5739 yjeM 54,725 amino acid transport [GO:0006865] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; amino acid transport [GO:0006865] amino acid transmembrane transporter activity [GO:0015171] GO:0005886; GO:0006865; GO:0015171; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AD17 YOHC_ECOLI Inner membrane protein YohC yohC b2135 JW5356 yohC 21,691 cellular response to DNA damage stimulus [GO:0006974] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cellular response to DNA damage stimulus [GO:0006974] GO:0005886; GO:0006974; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P39309 YTFA_ECOLI Putative uncharacterized protein YtfA ytfA b4205 JW4163 ytfA 12,247 +P43319 YRAK_ECOLI Uncharacterized fimbrial-like protein YraK yraK b3145 JW3114 yraK 38,535 cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. +P39314 YTFF_ECOLI Inner membrane protein YtfF ytfF b4210 JW4168 ytfF 35,208 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +Q6BEX0 YTFR_ECOLI Galactofuranose transporter ATP-binding protein YtfR (EC 7.5.2.9) ytfR ytfS b4485 JW5752 ytfS ytfR 55,260 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ABC-type D-galactofuranose transporter [GO:0103116]; ATP binding [GO:0005524] ABC-type D-galactofuranose transporter [GO:0103116]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0103116 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P0DSF7 YOAM_ECOLI Protein YoaM yoaM b4779 yoaM 1,230 +P41039 YBII_ECOLI Uncharacterized protein YbiI ybiI b0803 JW0788 ybiI 9,756 positive regulation of secondary metabolite biosynthetic process [GO:1900378] zinc ion binding [GO:0008270]; positive regulation of secondary metabolite biosynthetic process [GO:1900378] zinc ion binding [GO:0008270] GO:0008270; GO:1900378 +P75836 YCAN_ECOLI Uncharacterized HTH-type transcriptional regulator YcaN ycaN b0900 JW0883 ycaN 34,294 transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0006351; GO:0043565 +P75672 YAFS_ECOLI Uncharacterized protein YafS yafS b0213 JW0203 yafS 27,244 methyltransferase activity [GO:0008168] methyltransferase activity [GO:0008168] GO:0008168 +P75931 YCEM_ECOLI Putative oxidoreductase YceM (EC 1.-.-.-) yceM mviM b1068 JW1055 mviM yceM 33,682 nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491] nucleotide binding [GO:0000166]; oxidoreductase activity [GO:0016491] GO:0000166; GO:0016491 +Q47157 YAFO_ECOLI mRNA interferase toxin YafO (EC 3.1.-.-) (Endoribonuclease YafO) (Toxin YafO) yafO b0233 JW0223 yafO 15,488 DNA repair [GO:0006281]; negative regulation of translation [GO:0017148]; SOS response [GO:0009432] endoribonuclease activity [GO:0004521]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]; DNA repair [GO:0006281]; negative regulation of translation [GO:0017148]; SOS response [GO:0009432] endoribonuclease activity [GO:0004521]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723] GO:0003723; GO:0004521; GO:0006281; GO:0009432; GO:0017148; GO:0043023 +P75863 YCBX_ECOLI Uncharacterized protein YcbX ycbX b0947 JW5126 ycbX 40,644 response to toxic substance [GO:0009636]; toxin catabolic process [GO:0009407] 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; molybdenum ion binding [GO:0030151]; pyridoxal phosphate binding [GO:0030170]; response to toxic substance [GO:0009636]; toxin catabolic process [GO:0009407] 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; molybdenum ion binding [GO:0030151]; pyridoxal phosphate binding [GO:0030170] GO:0009055; GO:0009407; GO:0009636; GO:0030151; GO:0030170; GO:0051537 +P45807 YBAM_ECOLI Uncharacterized protein YbaM ybaM b0466 JW0455 ybaM 6,025 cellular response to cell envelope stress [GO:0036460] cellular response to cell envelope stress [GO:0036460] GO:0036460 +P0AAS7 YBCJ_ECOLI Uncharacterized protein YbcJ ybcJ b0528 JW5070 ybcJ 7,390 translation [GO:0006412] cytosol [GO:0005829] cytosol [GO:0005829]; RNA binding [GO:0003723]; translation [GO:0006412] RNA binding [GO:0003723] GO:0003723; GO:0005829; GO:0006412 +P67762 YHBP_ECOLI UPF0306 protein YhbP yhbP b3154 JW3123 yhbP 16,776 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P52052 YGGR_ECOLI Uncharacterized protein YggR yggR b2950 JW2917 yggR 35,994 cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524] ATP binding [GO:0005524] GO:0005524; GO:0005829 +P77318 YDEN_ECOLI Uncharacterized sulfatase YdeN (EC 3.1.6.-) ydeN b1498 JW5243 ydeN 62,802 outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872] GO:0004065; GO:0030288; GO:0046872 +P38521 YGGL_ECOLI Uncharacterized protein YggL yggL b2959 JW2926 yggL 12,881 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P76462 YFAP_ECOLI Uncharacterized protein YfaP yfaP b2225 JW2219 yfaP 28,304 +P77389 YDHP_ECOLI Inner membrane transport protein YdhP ydhP b1657 JW1649 ydhP 40,064 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77759 YLBH_ECOLI Putative uncharacterized protein YlbH ylbH b0499 JW0488 ylbH 26,960 +P64479 YDIZ_ECOLI Uncharacterized protein YdiZ ydiZ b1724 JW1713 ydiZ 10,865 cellular response to DNA damage stimulus [GO:0006974] endoribonuclease activity [GO:0004521]; cellular response to DNA damage stimulus [GO:0006974] endoribonuclease activity [GO:0004521] GO:0004521; GO:0006974 +P0ABW3 YFAE_ECOLI Uncharacterized ferredoxin-like protein YfaE yfaE b2236 JW2230 yfaE 9,293 cellular protein modification process [GO:0006464]; ferredoxin metabolic process [GO:0006124]; protein repair [GO:0030091] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; cellular protein modification process [GO:0006464]; ferredoxin metabolic process [GO:0006124]; protein repair [GO:0030091] 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] GO:0005737; GO:0006124; GO:0006464; GO:0009055; GO:0030091; GO:0046872; GO:0051537 +P0A8C8 YIDD_ECOLI Putative membrane protein insertion efficiency factor yidD b4557 JW3682 yidD 9,381 protein insertion into membrane [GO:0051205] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; membrane insertase activity [GO:0032977]; protein insertion into membrane [GO:0051205] membrane insertase activity [GO:0032977] GO:0005887; GO:0032977; GO:0051205 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00386, ECO:0000269|PubMed:21803992}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00386, ECO:0000269|PubMed:21803992}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_00386, ECO:0000269|PubMed:21803992}. Note=Associated with the inner membrane via a putative N-terminal amphipathic helix. +P07021 YFIB_ECOLI Putative lipoprotein YfiB yfiB b2605 JW2586 yfiB 17,245 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P31130 YDEI_ECOLI Uncharacterized protein YdeI ydeI b1536 JW1529 ydeI 14,121 cellular response to hydrogen peroxide [GO:0070301]; single-species biofilm formation on inanimate substrate [GO:0044011] cellular response to hydrogen peroxide [GO:0070301]; single-species biofilm formation on inanimate substrate [GO:0044011] GO:0044011; GO:0070301 +P0ACW6 YDCH_ECOLI Uncharacterized protein YdcH ydcH b1426 JW5823 ydcH 8,878 +P0ADN6 YIFL_ECOLI Uncharacterized lipoprotein YifL yifL b4558 JW3781 yifL 7,177 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P27837 YIFK_ECOLI Probable transport protein YifK yifK b3795 JW5595 yifK 50,399 amino acid transport [GO:0006865]; transmembrane transport [GO:0055085] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; amino acid transport [GO:0006865]; transmembrane transport [GO:0055085] GO:0005887; GO:0006865; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P39351 YJGZ_ECOLI Uncharacterized protein YjgZ yjgZ b4277 JW4236 yjgZ 12,161 +P0A8X0 YJGA_ECOLI UPF0307 protein YjgA (x96 protein) yjgA b4234 JW4193 yjgA 21,359 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16980477}. Note=Has been seen to comigrate with the 50S ribosomal subunit in sucrose gradients. +P45551 YHFY_ECOLI Uncharacterized protein YhfY yhfY b3382 JW5696 yhfY 13,528 regulation of transcription, DNA-templated [GO:0006355] regulation of transcription, DNA-templated [GO:0006355] GO:0006355 +P37663 YHJY_ECOLI Uncharacterized protein YhjY yhjY b3548 JW5659 yhjY 25,951 outer membrane [GO:0019867] outer membrane [GO:0019867] GO:0019867 +P0A8L5 YCGN_ECOLI UPF0260 protein YcgN ycgN b1181 JW5180 ycgN 17,910 +P77493 YDJH_ECOLI Uncharacterized sugar kinase YdjH (EC 2.7.1.-) ydjH b1772 JW5289 ydjH 34,121 kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773] kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773] GO:0016301; GO:0016773 +A5A621 YPFM_ECOLI Uncharacterized protein YpfM ypfM b4606 JW2454.1 ypfM 2,408 cytoplasm [GO:0005737] cytoplasm [GO:0005737] GO:0005737 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19121005}. +P76613 YPJC_ECOLI Protein YpjC ypjC b2650 JW5424 ypjC 18,024 +P77269 YPHF_ECOLI ABC transporter periplasmic-binding protein YphF yphF b2548 JW2532 yphF 35,058 outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; carbohydrate binding [GO:0030246] carbohydrate binding [GO:0030246] GO:0030246; GO:0030288 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P76239 YOAI_ECOLI Uncharacterized protein YoaI yoaI b1788 JW5885 yoaI 3,772 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021] GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +Q46919 YQCC_ECOLI Uncharacterized protein YqcC yqcC b2792 JW2763 yqcC 12,787 single-species biofilm formation [GO:0044010] single-species biofilm formation [GO:0044010] GO:0044010 +P77585 YPDE_ECOLI Aminopeptidase YpdE (EC 3.4.11.-) ypdE b2384 JW2381 ypdE 37,409 aminopeptidase activity [GO:0004177]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]; metallopeptidase activity [GO:0008237] aminopeptidase activity [GO:0004177]; metal ion binding [GO:0046872]; metalloaminopeptidase activity [GO:0070006]; metallopeptidase activity [GO:0008237] GO:0004177; GO:0008237; GO:0046872; GO:0070006 +P76356 YOEA_ECOLI Protein YoeA yoeA b4582 JW1980 b1995 b1998 yoeA 14,467 siderophore transmembrane transport [GO:0044718] intrinsic component of cell outer membrane [GO:0031230] intrinsic component of cell outer membrane [GO:0031230]; siderophore uptake transmembrane transporter activity [GO:0015344]; siderophore transmembrane transport [GO:0044718] siderophore uptake transmembrane transporter activity [GO:0015344] GO:0015344; GO:0031230; GO:0044718 +P76656 YQII_ECOLI Uncharacterized protein YqiI yqiI b3048 JW5509 yqiI 38,555 response to methylglyoxal [GO:0051595] response to methylglyoxal [GO:0051595] GO:0051595 +P77306 YQIK_ECOLI Inner membrane protein YqiK yqiK b3051 JW3023 yqiK 60,700 protein localization to plasma membrane [GO:0072659] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] cytosol [GO:0005829]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein localization to plasma membrane [GO:0072659] GO:0005829; GO:0005886; GO:0016021; GO:0072659 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein. +P37909 YBGD_ECOLI Uncharacterized fimbrial-like protein YbgD ybgD b0719 JW0709 ybgD 19,838 cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. +P37050 YADN_ECOLI Uncharacterized fimbrial-like protein YadN yadN b0141 JW0137 yadN 20,118 cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0007155; GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. +Q46844 YGHT_ECOLI Uncharacterized ATP-binding protein YghT yghT b2986 JW2954 yghT 25,356 ATP binding [GO:0005524] ATP binding [GO:0005524] GO:0005524 +P0ADS6 YGGE_ECOLI Uncharacterized protein YggE yggE b2922 JW2889 yggE 26,635 cellular response to DNA damage stimulus [GO:0006974]; cellular response to heat [GO:0034605]; cellular response to reactive oxygen species [GO:0034614] integral component of external side of plasma membrane [GO:0071575] integral component of external side of plasma membrane [GO:0071575]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to heat [GO:0034605]; cellular response to reactive oxygen species [GO:0034614] GO:0006974; GO:0034605; GO:0034614; GO:0071575 +P76505 YFDF_ECOLI Uncharacterized protein YfdF yfdF b2345 JW2342 yfdF 40,249 +P77561 YDEP_ECOLI Protein YdeP ydeP b1501 JW1495 ydeP 83,495 response to acidic pH [GO:0010447] 4 iron, 4 sulfur cluster binding [GO:0051539]; formate dehydrogenase (NAD+) activity [GO:0008863]; molybdenum ion binding [GO:0030151]; response to acidic pH [GO:0010447] 4 iron, 4 sulfur cluster binding [GO:0051539]; formate dehydrogenase (NAD+) activity [GO:0008863]; molybdenum ion binding [GO:0030151] GO:0008863; GO:0010447; GO:0030151; GO:0051539 +P76500 YFCQ_ECOLI Uncharacterized fimbrial-like protein YfcQ yfcQ b2334 JW2331 yfcQ 17,890 cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0007155; GO:0009289; GO:0043709; GO:0043711 +P76186 YDHK_ECOLI Uncharacterized transporter YdhK ydhK b1645 JW1637 ydhK 75,267 transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; transmembrane transport [GO:0055085] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857; GO:0055085 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P39836 YFEH_ECOLI Putative symporter YfeH yfeH b2410 JW5876 yfeH 36,406 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; symporter activity [GO:0015293] symporter activity [GO:0015293] GO:0005886; GO:0015293 +Q47702 YFEK_ECOLI Uncharacterized protein YfeK yfeK b2419 JW2412 yfeK 13,732 +Q46906 YGCP_ECOLI Uncharacterized protein YgcP ygcP b2768 JW2738 ygcP 20,786 glycerol metabolic process [GO:0006071] transcription antitermination factor activity, RNA binding [GO:0001072]; glycerol metabolic process [GO:0006071] transcription antitermination factor activity, RNA binding [GO:0001072] GO:0001072; GO:0006071 +P64622 YHDV_ECOLI Uncharacterized protein YhdV yhdV b3267 JW3235 yhdV 7,452 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Multi-pass membrane protein {ECO:0000305}. +P77795 YDCT_ECOLI Uncharacterized ABC transporter ATP-binding protein YdcT ydcT b1441 JW1436 ydcT 37,041 ATP-binding cassette (ABC) transporter complex [GO:0043190] ATP-binding cassette (ABC) transporter complex [GO:0043190]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0042626; GO:0043190 +P77295 YGAV_ECOLI Probable HTH-type transcriptional regulator YgaV ygaV b2667 JW2642 ygaV 10,596 regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355 +P76061 YDAG_ECOLI Uncharacterized protein YdaG ydaG b1355 JW5210 ydaG 5,194 +P0ADM6 YIDX_ECOLI Uncharacterized protein YidX yidX b3696 JW5858 yidX 24,170 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021] GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P75967 YMFD_ECOLI Uncharacterized protein YmfD ymfD b1137 JW1123 ymfD 25,147 +P33347 YEHK_ECOLI Uncharacterized protein YehK yehK b4541 JW2106 yehK 12,603 +P52645 YDBH_ECOLI Uncharacterized protein YdbH ydbH b1381 JW1376 ydbH 96,835 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 +Q9Z3A0 YJGW_ECOLI Putative uncharacterized protein YjgW yjgW b4274 JW4233 yjgW 13,085 +P32693 YJBL_ECOLI Uncharacterized protein YjbL yjbL b4047 JW4007 yjbL 9,749 +P76319 YEDL_ECOLI Uncharacterized N-acetyltransferase YedL (EC 2.3.1.-) yedL b1932 JW1917 yedL 17,891 N-acetyltransferase activity [GO:0008080] N-acetyltransferase activity [GO:0008080] GO:0008080 +P0A8A2 YEEN_ECOLI Probable transcriptional regulatory protein YeeN yeeN b1983 JW1964 yeeN 25,867 regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677] GO:0003677; GO:0005829; GO:0006355 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00918}. +P0ADX1 YHFA_ECOLI Protein YhfA yhfA b3356 JW3319 yhfA 14,517 +P37635 YHIS_ECOLI Putative uncharacterized protein YhiS yhiS b3504 JW3471 yhiS 29,450 +P39410 YJJJ_ECOLI Toxin YjjJ (Putative DNA-binding transcriptional regulator YjjJ) (Putative serine/threonine kinase toxin YjjJ) (EC 2.-.-.-) yjjJ b4385 JW4348 yjjJ 49,757 cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; protein serine/threonine kinase activity [GO:0004674]; toxin activity [GO:0090729] DNA binding [GO:0003677]; protein serine/threonine kinase activity [GO:0004674]; toxin activity [GO:0090729] GO:0003677; GO:0004674; GO:0005829; GO:0090729 +P39391 YJIT_ECOLI Protein YjiT yjiT b4342 JW5787 yjiT 58,553 +P77704 YDJI_ECOLI Uncharacterized protein YdjI ydjI b1773 JW1762 ydjI 30,810 carbohydrate metabolic process [GO:0005975] cytosol [GO:0005829] cytosol [GO:0005829]; tagatose-bisphosphate aldolase activity [GO:0009025]; zinc ion binding [GO:0008270]; carbohydrate metabolic process [GO:0005975] tagatose-bisphosphate aldolase activity [GO:0009025]; zinc ion binding [GO:0008270] GO:0005829; GO:0005975; GO:0008270; GO:0009025 +P0AF56 YJCO_ECOLI Sel1-repeat-containing protein YjcO yjcO b4078 JW4039 yjcO 25,079 enzyme activator activity [GO:0008047] enzyme activator activity [GO:0008047] GO:0008047 +Q2EET2 YPFN_ECOLI UPF0370 protein YpfN ypfN b4547 JW2457 ypfN 8,071 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01566}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01566}. +P76586 YPHH_ECOLI Uncharacterized protein YphH yphH b2550 JW5406 yphH 44,521 +P76344 ZINT_ECOLI Metal-binding protein ZinT (Cadmium-induced protein ZinT) zinT yodA b1973 JW1956 yodA zinT 24,762 cellular response to cadmium ion [GO:0071276]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to zinc ion starvation [GO:0034224]; cellular zinc ion homeostasis [GO:0006882] cytosol [GO:0005829]; outer membrane-bounded periplasmic space [GO:0030288] cytosol [GO:0005829]; outer membrane-bounded periplasmic space [GO:0030288]; cadmium ion binding [GO:0046870]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270]; cellular response to cadmium ion [GO:0071276]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to zinc ion starvation [GO:0034224]; cellular zinc ion homeostasis [GO:0006882] cadmium ion binding [GO:0046870]; metal ion binding [GO:0046872]; zinc ion binding [GO:0008270] GO:0005829; GO:0006882; GO:0008270; GO:0030288; GO:0034224; GO:0046870; GO:0046872; GO:0070301; GO:0071276 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12480884}. Periplasm {ECO:0000269|PubMed:12480884}. Note=Cytoplasmic in nonstressed cells, and exported to the periplasm upon exposure to cadmium. +P46856 YRHA_ECOLI Putative uncharacterized protein YrhA yrhA b3443 JW5864 yrhA 15,950 +P77173 ZIPA_ECOLI Cell division protein ZipA (FtsZ interacting protein A) zipA b2412 JW2404 zipA 36,475 division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093] cell division site [GO:0032153]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cell division site [GO:0032153]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; division septum assembly [GO:0000917]; FtsZ-dependent cytokinesis [GO:0043093] GO:0000917; GO:0005886; GO:0005887; GO:0032153; GO:0043093 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:9008158}; Single-pass type I membrane protein {ECO:0000269|PubMed:9008158}. Note=Localizes to the Z ring in an FtsZ-dependent manner (PubMed:9008158, PubMed:9864327, PubMed:10209756). Localization does not depend upon FtsA or FtsI (PubMed:9864327, PubMed:10209756). {ECO:0000269|PubMed:10209756, ECO:0000269|PubMed:9008158, ECO:0000269|PubMed:9864327}. +P0DPC4 YTIC_ECOLI Protein YtiC ytiC ytiB b4720 ytiB ytiC 3,949 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. +C1P604 YOBI_ECOLI Uncharacterized protein YobI yobI b4677 JW1850.1 yobI 2,665 +C1P620 YSHB_ECOLI Uncharacterized protein YshB yshB b4686 JW3839.1 yshB 3,618 +P0AD40 YPEB_ECOLI Uncharacterized protein YpeB ypeB b4546 JW5877 ypeB 8,415 +P76657 YQIJ_ECOLI Inner membrane protein YqiJ yqiJ b3050 JW3022 yqiJ 23,087 cellular response to DNA damage stimulus [GO:0006974] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cellular response to DNA damage stimulus [GO:0006974] GO:0005886; GO:0006974; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76116 YNCE_ECOLI Uncharacterized protein YncE yncE b1452 JW1447 yncE 38,613 outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; DNA binding [GO:0003677] DNA binding [GO:0003677] GO:0003677; GO:0030288 +P76148 YNEG_ECOLI Uncharacterized protein YneG yneG b1523 JW1516 yneG 13,544 +P46888 USPC_ECOLI Universal stress protein C uspC yecG b1895 JW1884 yecG uspC 15,633 cellular response to starvation [GO:0009267]; cellular response to UV [GO:0034644]; response to salt stress [GO:0009651] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; molecular adaptor activity [GO:0060090]; cellular response to starvation [GO:0009267]; cellular response to UV [GO:0034644]; response to salt stress [GO:0009651] molecular adaptor activity [GO:0060090] GO:0005737; GO:0009267; GO:0009651; GO:0034644; GO:0060090 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P36667 WBBL_ECOLI Rhamnosyltransferase WbbL (EC 2.4.1.-) wbbL b4571 JW2016 b2031 wbbL 31,061 extracellular polysaccharide biosynthetic process [GO:0045226]; lipopolysaccharide biosynthetic process [GO:0009103] transferase activity, transferring hexosyl groups [GO:0016758]; extracellular polysaccharide biosynthetic process [GO:0045226]; lipopolysaccharide biosynthetic process [GO:0009103] transferase activity, transferring hexosyl groups [GO:0016758] GO:0009103; GO:0016758; GO:0045226 +P0AAQ2 YAJD_ECOLI Putative HNH nuclease YajD (EC 3.1.-.-) yajD b0410 JW0400 yajD 13,364 cytosol [GO:0005829] cytosol [GO:0005829]; endonuclease activity [GO:0004519]; nucleic acid binding [GO:0003676] endonuclease activity [GO:0004519]; nucleic acid binding [GO:0003676] GO:0003676; GO:0004519; GO:0005829 +P0AB31 YCEK_ECOLI Uncharacterized protein YceK yceK b1050 JW5151 yceK 8,443 cellular response to DNA damage stimulus [GO:0006974] intrinsic component of periplasmic side of cell outer membrane [GO:0031246] intrinsic component of periplasmic side of cell outer membrane [GO:0031246]; cellular response to DNA damage stimulus [GO:0006974] GO:0006974; GO:0031246 +P75870 YCCS_ECOLI Inner membrane protein YccS yccS b0960 JW5128 yccS 81,668 transmembrane transport [GO:0055085] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; transmembrane transport [GO:0055085] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0022857; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AB14 YCCJ_ECOLI Uncharacterized protein YccJ yccJ b1003 JW0988 yccJ 8,524 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P75741 YBFL_ECOLI Putative protein YbfL (H repeat-associated protein in rhsC-phrB intergenic region) (ORF-H2) ybfL b0705 JW0695 ybfL 43,161 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P76134 YDEM_ECOLI Anaerobic sulfatase-maturating enzyme homolog YdeM (AnSME homolog) ydeM b1497 JW1492 ydeM 44,518 cellular response to DNA damage stimulus [GO:0006974]; protein maturation [GO:0051604] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; cellular response to DNA damage stimulus [GO:0006974]; protein maturation [GO:0051604] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] GO:0006974; GO:0016491; GO:0046872; GO:0051539; GO:0051604 +P0A6D5 YDIB_ECOLI Quinate/shikimate dehydrogenase (EC 1.1.1.282) (NAD-dependent shikimate 5-dehydrogenase) ydiB ydiB 31,228 aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423]; shikimate metabolic process [GO:0019632] quinate 3-dehydrogenase (NAD+) activity [GO:0030266]; quinate 3-dehydrogenase (NADP+) activity [GO:0052733]; shikimate 3-dehydrogenase (NAD+) activity [GO:0052734]; shikimate 3-dehydrogenase (NADP+) activity [GO:0004764]; aromatic amino acid family biosynthetic process [GO:0009073]; cellular amino acid biosynthetic process [GO:0008652]; chorismate biosynthetic process [GO:0009423]; shikimate metabolic process [GO:0019632] quinate 3-dehydrogenase (NAD+) activity [GO:0030266]; quinate 3-dehydrogenase (NADP+) activity [GO:0052733]; shikimate 3-dehydrogenase (NAD+) activity [GO:0052734]; shikimate 3-dehydrogenase (NADP+) activity [GO:0004764] GO:0004764; GO:0008652; GO:0009073; GO:0009423; GO:0019632; GO:0030266; GO:0052733; GO:0052734 +P76180 YDGK_ECOLI Inner membrane protein YdgK ydgK b1626 JW1618 ydgK 16,319 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P64624 YHEO_ECOLI Uncharacterized protein YheO yheO b3346 JW5703 yheO 26,821 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P64592 YHAI_ECOLI Inner membrane protein YhaI yhaI b3104 JW3075 yhaI 13,456 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76185 YDHJ_ECOLI Uncharacterized protein YdhJ ydhJ b1644 JW1636 ydhJ 31,496 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P42625 YHAL_ECOLI Uncharacterized protein YhaL yhaL b3107 JW5517 yhaL 5,961 +P76046 YCJX_ECOLI Uncharacterized protein YcjX ycjX b1321 JW1314 ycjX 52,609 ATP binding [GO:0005524] ATP binding [GO:0005524] GO:0005524 +P21362 YCIF_ECOLI Protein YciF yciF b1258 JW1250 yciF 18,597 cellular response to DNA damage stimulus [GO:0006974] cellular response to DNA damage stimulus [GO:0006974] GO:0006974 +P46141 YGBE_ECOLI Inner membrane protein YgbE ygbE b2749 JW2719 ygbE 12,017 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AA91 YEAY_ECOLI Uncharacterized lipoprotein YeaY yeaY b1806 JW1795 yeaY 20,921 outer membrane [GO:0019867]; plasma membrane [GO:0005886] outer membrane [GO:0019867]; plasma membrane [GO:0005886] GO:0005886; GO:0019867 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P76418 YEGU_ECOLI Uncharacterized protein YegU (EC 3.2.2.-) yegU b2099 JW2086 yegU 35,621 hydrolase activity [GO:0016787] hydrolase activity [GO:0016787] GO:0016787 +P0CB62 YMIA_ECOLI Protein YmiA ymiA b4522 JW1267.1 ymiA 5,337 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P67699 YDDM_ECOLI Uncharacterized HTH-type transcriptional regulator YddM yddM b1477 JW5908 yddM 10,401 DNA binding [GO:0003677] DNA binding [GO:0003677] GO:0003677 +P76308 YECR_ECOLI Uncharacterized protein YecR yecR b1904 JW1892 yecR 11,741 +P38055 YDJE_ECOLI Inner membrane metabolite transport protein YdjE ydjE b1769 JW1758 ydjE 50,318 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AFV2 YHID_ECOLI Putative magnesium transporter YhiD yhiD yhhE b3508 JW5670 yhhE yhiD 23,213 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P77539 YDJL_ECOLI Uncharacterized zinc-type alcohol dehydrogenase-like protein YdjL (EC 1.-.-.-) ydjL b1776 JW1765 ydjL 38,732 oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] GO:0008270; GO:0016491 +P0A8Z0 YCIA_ECOLI Acyl-CoA thioester hydrolase YciA (EC 3.1.2.-) (Protein P14) yciA b1253 JW1245 yciA 14,231 acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631] cytosol [GO:0005829] cytosol [GO:0005829]; acyl-CoA hydrolase activity [GO:0047617]; long-chain fatty acyl-CoA binding [GO:0036042]; acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631] acyl-CoA hydrolase activity [GO:0047617]; long-chain fatty acyl-CoA binding [GO:0036042] GO:0005829; GO:0006631; GO:0006637; GO:0036042; GO:0047617 +P25743 YCHE_ECOLI UPF0056 membrane protein YhcE ychE b1242 JW1229 ychE 23,521 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] GO:0005886; GO:0005887 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P64570 YQGC_ECOLI Protein YqgC yqgC b2940 JW2907 yqgC 8,114 +P0AD21 YEJG_ECOLI Uncharacterized protein YejG yejG b2181 JW2169 yejG 12,525 +P58033 YPJJ_ECOLI Uncharacterized protein YpjJ ypjJ b4548 JW5421 ypjJ 7,861 +P39310 YTFB_ECOLI Cell division protein YtfB ytfB b4206 JW5745 ytfB 23,505 FtsZ-dependent cytokinesis [GO:0043093]; septum digestion after cytokinesis [GO:0000920] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; metalloendopeptidase activity [GO:0004222]; peptidoglycan binding [GO:0042834]; FtsZ-dependent cytokinesis [GO:0043093]; septum digestion after cytokinesis [GO:0000920] metalloendopeptidase activity [GO:0004222]; peptidoglycan binding [GO:0042834] GO:0000920; GO:0004222; GO:0005886; GO:0016021; GO:0042834; GO:0043093 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to the septal ring prior to the onset of constriction and remains at the midcell throughout cytokinesis. Recruitment to the septal ring requires FtsZ, but not downstream division proteins. {ECO:0000269|PubMed:29686141}. +P64432 YPJD_ECOLI Inner membrane protein YpjD ypjD b2611 JW2592 ypjD 29,262 cytochrome complex assembly [GO:0017004] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; heme binding [GO:0020037]; cytochrome complex assembly [GO:0017004] heme binding [GO:0020037] GO:0005886; GO:0016021; GO:0017004; GO:0020037 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0DPC5 YTID_ECOLI Protein YtiD ytiD b4721 ytiD 5,511 +C1P603 YOAJ_ECOLI Uncharacterized protein YoaJ yoaJ b4675 JW5292.2 yoaJ 2,691 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:19121005, ECO:0000305|PubMed:21778229}; Single-pass membrane protein {ECO:0000269|PubMed:19121005, ECO:0000269|PubMed:21778229}. Note=Some protein is also seen in the soluble fraction of the cell extracts. +P0AAA9 ZRAP_ECOLI Zinc resistance-associated protein zraP yjaI zra b4002 JW5546 yjaI zra zraP 15,199 cellular response to cell envelope stress [GO:0036460] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; cobalt ion binding [GO:0050897]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270]; cellular response to cell envelope stress [GO:0036460] cobalt ion binding [GO:0050897]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270] GO:0005507; GO:0008270; GO:0016151; GO:0030288; GO:0036460; GO:0042802; GO:0050897 SUBCELLULAR LOCATION: Periplasm. +P0A890 TUSA_ECOLI Sulfur carrier protein TusA (Sulfur mediator TusA) (Sulfur transfer protein TusA) (tRNA 2-thiouridine synthesizing protein A) tusA sirA yhhP b3470 JW3435 sirA yhhP tusA 9,095 Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; tRNA wobble position uridine thiolation [GO:0002143] cytosol [GO:0005829] cytosol [GO:0005829]; sulfur carrier activity [GO:0097163]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; tRNA wobble position uridine thiolation [GO:0002143] sulfur carrier activity [GO:0097163] GO:0002143; GO:0005829; GO:0006777; GO:0097163 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00413, ECO:0000269|PubMed:10830496}. +P0ADN0 VIAA_ECOLI Protein ViaA (VWA domain protein interacting with AAA ATPase) viaA yieD yieM b3745 JW5610 yieD yieM viaA 55,907 positive regulation of ATPase activity [GO:0032781] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; positive regulation of ATPase activity [GO:0032781] GO:0005829; GO:0016020; GO:0032781 +P62066 YCEQ_ECOLI Uncharacterized protein YceQ yceQ b1085 JW5154 yceQ 12,100 +P21503 YCAD_ECOLI Uncharacterized MFS-type transporter YcaD ycaD b0898 JW0881 ycaD 41,432 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P30143 YAAJ_ECOLI Uncharacterized transporter YaaJ yaaJ b0007 JW0006 yaaJ 51,663 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; alanine:sodium symporter activity [GO:0015655] alanine:sodium symporter activity [GO:0015655] GO:0005886; GO:0015655; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P77169 YAGJ_ECOLI Protein YagJ yagJ b0276 JW0270 yagJ 27,859 response to X-ray [GO:0010165] response to X-ray [GO:0010165] GO:0010165 +P76135 YDEO_ECOLI HTH-type transcriptional regulator YdeO ydeO b1499 JW1494 ydeO 28,725 positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0006351; GO:0043565; GO:0045893 +P76544 YFFM_ECOLI Uncharacterized protein YffM yffM b2444 yffM 9,206 +P0AD33 YFCZ_ECOLI UPF0381 protein YfcZ yfcZ b2343 JW2340 yfcZ 10,318 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P76483 YFBM_ECOLI Protein YfbM yfbM b2272 JW2267 yfbM 19,019 +P31455 YIDR_ECOLI Uncharacterized protein YidR yidR b3689 JW5860 yidR 46,187 galacturonate catabolic process [GO:0046397] galacturonate catabolic process [GO:0046397] GO:0046397 +P64619 YHDU_ECOLI Inner membrane protein YhdU yhdU b3263 JW3231 yhdU 7,204 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P33634 YFIE_ECOLI Uncharacterized HTH-type transcriptional regulator YfiE yfiE b2577 JW2561 yfiE 33,243 regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355 +P36677 YHDN_ECOLI Uncharacterized protein YhdN yhdN b3293 JW3255 yhdN 13,945 +P0AGJ5 YFIF_ECOLI Uncharacterized tRNA/rRNA methyltransferase YfiF (EC 2.1.1.-) yfiF b2581 JW2565 yfiF 37,784 RNA methylation [GO:0001510]; RNA processing [GO:0006396] cytosol [GO:0005829] cytosol [GO:0005829]; RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173]; RNA methylation [GO:0001510]; RNA processing [GO:0006396] RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173] GO:0001510; GO:0003723; GO:0005829; GO:0006396; GO:0008173 +P67127 YGDQ_ECOLI UPF0053 inner membrane protein YgdQ ygdQ b2832 JW2800 ygdQ 26,157 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +A5A611 YMGI_ECOLI Uncharacterized protein YmgI ymgI b4593 ymgI 6,518 +P0DPN8 YMGK_ECOLI Protein YmgK ymgK b4738 ymgK 1,589 +P0ADK0 YIAF_ECOLI Uncharacterized protein YiaF yiaF b3554 JW5655 yiaF 25,663 multi-organism cellular process [GO:0044764] multi-organism cellular process [GO:0044764] GO:0044764 +P33342 YEHC_ECOLI Probable fimbrial chaperone YehC yehC b2110 JW2097 yehC 26,589 cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] GO:0030288; GO:0043711; GO:0061077; GO:0071555 SUBCELLULAR LOCATION: Periplasm {ECO:0000250}. +P31463 YIDZ_ECOLI HTH-type transcriptional regulator YidZ yidZ b3711 JW3689 yidZ 36,882 regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006351; GO:0006355 +P33011 YEEA_ECOLI Inner membrane protein YeeA yeeA b2008 JW1990 yeeA 39,955 transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; transmembrane transport [GO:0055085] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0DSH9 YKIE_ECOLI Protein YkiE ykiE b4801 ykiE 2,720 +P33218 YEBE_ECOLI Inner membrane protein YebE yebE b1846 JW1835 yebE 23,687 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane protein. +P23839 YICC_ECOLI UPF0701 protein YicC yicC b3644 JW3619 yicC 33,175 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P0AD05 YECA_ECOLI Uncharacterized protein YecA yecA b1908 JW1896 yecA 25,039 +P21365 YCIC_ECOLI UPF0259 membrane protein YciC yciC b1255 JW1247 yciC 26,419 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P52134 YPJK_ECOLI Uncharacterized protein YpjK ypjK b2635 JW5888 ypjK 7,703 +C1P602 YOAK_ECOLI Uncharacterized membrane protein YoaK yoaK b4676 JW5292.1 yoaK 3,458 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:19121005, ECO:0000305|PubMed:21778229}; Single-pass membrane protein {ECO:0000269|PubMed:19121005, ECO:0000269|PubMed:21778229}. Note=May be able to insert into the membrane in both orientations. Relies on YidC for insertion. +Q2M5U1 YTJA_ECOLI UPF0391 membrane protein YtjA ytjA b4568 JW5891 ytjA 5,536 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01361}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01361}. +Q2MB16 YOBH_ECOLI Uncharacterized protein YobH yobH b4536 JW5298 yobH 8,514 +P69348 YOEB_ECOLI Toxin YoeB (EC 3.1.-.-) (Putative endoribonuclease YoeB) (Putative mRNA interferase Yoeb) yoeB b4539 JW5331 yoeB 10,216 mRNA catabolic process [GO:0006402]; mRNA cleavage involved in gene silencing [GO:0098795]; negative regulation of nucleic acid-templated transcription [GO:1903507]; negative regulation of translational initiation [GO:0045947]; response to heat [GO:0009408]; RNA catabolic process [GO:0006401]; single-species biofilm formation [GO:0044010] endoribonuclease activity [GO:0004521]; endoribonuclease activity, producing 3'-phosphomonoesters [GO:0016892]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; mRNA catabolic process [GO:0006402]; mRNA cleavage involved in gene silencing [GO:0098795]; negative regulation of nucleic acid-templated transcription [GO:1903507]; negative regulation of translational initiation [GO:0045947]; response to heat [GO:0009408]; RNA catabolic process [GO:0006401]; single-species biofilm formation [GO:0044010] endoribonuclease activity [GO:0004521]; endoribonuclease activity, producing 3'-phosphomonoesters [GO:0016892]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723] GO:0003723; GO:0004521; GO:0006401; GO:0006402; GO:0009408; GO:0016892; GO:0043024; GO:0044010; GO:0045947; GO:0098795; GO:1903507 +P76909 YNJD_ECOLI Uncharacterized ABC transporter ATP-binding protein YnjD ynjD b1756 JW5286 ynjD 24,017 ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0042626 +P42619 YQJF_ECOLI Inner membrane protein YqjF yqjF b3101 JW5850 yqjF 14,102 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76115 YNCD_ECOLI Probable TonB-dependent receptor YncD yncD b1451 JW1446 yncD 77,261 siderophore transmembrane transport [GO:0044718] integral component of membrane [GO:0016021]; intrinsic component of cell outer membrane [GO:0031230] integral component of membrane [GO:0016021]; intrinsic component of cell outer membrane [GO:0031230]; siderophore uptake transmembrane transporter activity [GO:0015344]; signaling receptor activity [GO:0038023]; siderophore transmembrane transport [GO:0044718] siderophore uptake transmembrane transporter activity [GO:0015344]; signaling receptor activity [GO:0038023] GO:0015344; GO:0016021; GO:0031230; GO:0038023; GO:0044718 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P0AA63 YQJA_ECOLI Inner membrane protein YqjA yqjA b3095 JW3066 yqjA 24,585 FtsZ-dependent cytokinesis [GO:0043093]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; FtsZ-dependent cytokinesis [GO:0043093]; transmembrane transport [GO:0055085] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857; GO:0043093; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P64599 UBIT_ECOLI Ubiquinone biosynthesis accessory factor UbiT ubiT yhbT b3157 JW3126 yhbT ubiT 19,672 ubiquinone biosynthetic process from chorismate [GO:0032150] cytosol [GO:0005829] cytosol [GO:0005829]; ubiquinone biosynthetic process from chorismate [GO:0032150] GO:0005829; GO:0032150 +P39177 USPG_ECOLI Universal stress protein UP12 (Universal stress protein G) uspG ybdQ yzzU b0607 JW0600 ybdQ yzzU uspG 15,935 protein adenylylation [GO:0018117]; protein autophosphorylation [GO:0046777]; regulation of cell motility [GO:2000145] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; adenylate kinase activity [GO:0004017]; protein adenylylation [GO:0018117]; protein autophosphorylation [GO:0046777]; regulation of cell motility [GO:2000145] adenylate kinase activity [GO:0004017] GO:0004017; GO:0005737; GO:0018117; GO:0046777; GO:2000145 +P0AC78 WECA_ECOLI Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.33) (UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase) (Undecaprenyl-phosphate GlcNAc-1-phosphate transferase) wecA rfe b3784 JW3758 rfe wecA 40,957 cell wall macromolecule biosynthetic process [GO:0044038]; cell wall organization [GO:0071555]; enterobacterial common antigen biosynthetic process [GO:0009246]; lipopolysaccharide biosynthetic process [GO:0009103]; O antigen biosynthetic process [GO:0009243] Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; drug binding [GO:0008144]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; phospho-N-acetylmuramoyl-pentapeptide-transferase activity [GO:0008963]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; transferase activity, transferring glycosyl groups [GO:0016757]; UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity [GO:0036380]; cell wall macromolecule biosynthetic process [GO:0044038]; cell wall organization [GO:0071555]; enterobacterial common antigen biosynthetic process [GO:0009246]; lipopolysaccharide biosynthetic process [GO:0009103]; O antigen biosynthetic process [GO:0009243] drug binding [GO:0008144]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; phospho-N-acetylmuramoyl-pentapeptide-transferase activity [GO:0008963]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; transferase activity, transferring glycosyl groups [GO:0016757]; UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity [GO:0036380] GO:0000287; GO:0005886; GO:0005887; GO:0008144; GO:0008963; GO:0009103; GO:0009243; GO:0009246; GO:0009276; GO:0016020; GO:0016021; GO:0016757; GO:0016780; GO:0030145; GO:0036380; GO:0042802; GO:0044038; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02030, ECO:0000269|PubMed:11700352, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:17237164}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02030}. Note=Localizes to discrete regions in the plasma membrane. {ECO:0000269|PubMed:17237164}. +P0A8I3 YAAA_ECOLI Peroxide stress resistance protein YaaA (UPF0246 protein YaaA) yaaA b0006 JW0005 yaaA 29,586 response to hydroperoxide [GO:0033194] cytosol [GO:0005829] cytosol [GO:0005829]; response to hydroperoxide [GO:0033194] GO:0005829; GO:0033194 +P0AAU2 YBFA_ECOLI Uncharacterized protein YbfA ybfA b0699 JW0688 ybfA 8,275 response to radiation [GO:0009314] response to radiation [GO:0009314] GO:0009314 +P77506 YBDJ_ECOLI Uncharacterized protein YbdJ ybdJ b0580 JW0569 ybdJ 9,404 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P33668 YBBC_ECOLI Uncharacterized protein YbbC ybbC b0498 JW0487 ybbC 14,152 +P76156 YDFO_ECOLI Uncharacterized protein YdfO ydfO b1549 JW5252 ydfO 16,497 +P77228 YDFJ_ECOLI Putative transporter YdfJ ydfJ b1543 JW1536 b4600 ydfJ 46,267 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; potassium channel activity [GO:0005267]; symporter activity [GO:0015293] potassium channel activity [GO:0005267]; symporter activity [GO:0015293] GO:0005267; GO:0005886; GO:0015293; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein. Note=When overexpressed using vectors that provide a promoter and ribosome binding site (PubMed:15919996). {ECO:0000269|PubMed:15919996}. +Q46833 YGHE_ECOLI Putative type II secretion system L-type protein YghE (Putative general secretion pathway L-type protein YghE) yghE b2969 yghE 32,058 protein secretion by the type II secretion system [GO:0015628] Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627] Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627]; protein secretion by the type II secretion system [GO:0015628] GO:0005886; GO:0009276; GO:0015627; GO:0015628; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}. +P0A9U8 YDIO_ECOLI Probable acyl-CoA dehydrogenase YdiO (EC 1.3.-.-) ydiO b1695 JW5275 ydiO 43,002 1-butanol biosynthetic process [GO:0071271] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660]; 1-butanol biosynthetic process [GO:0071271] acyl-CoA dehydrogenase activity [GO:0003995]; flavin adenine dinucleotide binding [GO:0050660] GO:0003995; GO:0050660; GO:0071271 +P76520 YFDX_ECOLI Protein YfdX yfdX b2375 JW2372 yfdX 22,977 +P55734 YGAP_ECOLI Inner membrane protein YgaP ygaP b2668 JW2643 ygaP 18,639 integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; thiosulfate sulfurtransferase activity [GO:0004792] thiosulfate sulfurtransferase activity [GO:0004792] GO:0004792; GO:0005887 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +Q46892 YGBN_ECOLI Inner membrane permease YgbN ygbN b2740 JW2710 ygbN 46,770 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; gluconate transmembrane transporter activity [GO:0015128] gluconate transmembrane transporter activity [GO:0015128] GO:0005886; GO:0005887; GO:0015128 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P42626 YHAM_ECOLI UPF0597 protein YhaM yhaM yhaN b4470 JW5518 yhaN yhaM 45,361 cysteine catabolic process [GO:0009093]; L-cysteine catabolic process to pyruvate [GO:0019450]; response to L-cysteine [GO:1901367] L-cysteine desulfhydrase activity [GO:0080146]; cysteine catabolic process [GO:0009093]; L-cysteine catabolic process to pyruvate [GO:0019450]; response to L-cysteine [GO:1901367] L-cysteine desulfhydrase activity [GO:0080146] GO:0009093; GO:0019450; GO:0080146; GO:1901367 +P64545 YFGG_ECOLI Protein YfgG yfgG b2504 JW5399 yfgG 7,462 stress response to metal ion [GO:0097501]; stress response to nickel ion [GO:1990532] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; stress response to metal ion [GO:0097501]; stress response to nickel ion [GO:1990532] GO:0005886; GO:0016021; GO:0097501; GO:1990532 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P21363 YCIE_ECOLI Protein YciE yciE b1257 JW1249 yciE 18,961 +P33345 YEHF_ECOLI Protein YehF yehF dinO molR sosF b2115 b2116/b2117 b4499 dinO molR sosF yehF 30,613 +P62723 YEIH_ECOLI UPF0324 inner membrane protein YeiH yeiH b2158 JW2145 yeiH 36,882 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AD27 YEJM_ECOLI Inner membrane protein YejM yejM yejN b2188 JW2176 yejN yejM 67,296 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; sulfuric ester hydrolase activity [GO:0008484] sulfuric ester hydrolase activity [GO:0008484] GO:0005886; GO:0008484; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0DPN2 YKID_ECOLI Protein YkiD ykiD b4732 ykiD 3,234 +P76352 YEEO_ECOLI Probable FMN/FAD exporter YeeO yeeO b1985 JW1965 yeeO 60,061 dipeptide transmembrane transport [GO:0035442]; FAD transmembrane transport [GO:0035350]; protein transport [GO:0015031] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; antiporter activity [GO:0015297]; dipeptide transmembrane transporter activity [GO:0071916]; FAD transmembrane transporter activity [GO:0015230]; FMN transmembrane transporter activity [GO:0044610]; xenobiotic transmembrane transporter activity [GO:0042910]; dipeptide transmembrane transport [GO:0035442]; FAD transmembrane transport [GO:0035350]; protein transport [GO:0015031] antiporter activity [GO:0015297]; dipeptide transmembrane transporter activity [GO:0071916]; FAD transmembrane transporter activity [GO:0015230]; FMN transmembrane transporter activity [GO:0044610]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0005886; GO:0015031; GO:0015230; GO:0015297; GO:0016020; GO:0016021; GO:0035350; GO:0035442; GO:0042910; GO:0044610; GO:0071916 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +Q47719 YJHV_ECOLI Putative protein YjhV yjhV b4286 JW4246 yjhV 15,067 +P46837 YHGF_ECOLI Protein YhgF yhgF b3407 JW3370 yhgF 85,120 nucleobase-containing compound metabolic process [GO:0006139]; response to ionizing radiation [GO:0010212]; translation [GO:0006412] cytosol [GO:0005829] cytosol [GO:0005829]; mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735]; nucleobase-containing compound metabolic process [GO:0006139]; response to ionizing radiation [GO:0010212]; translation [GO:0006412] mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735] GO:0003729; GO:0003735; GO:0005829; GO:0006139; GO:0006412; GO:0010212 +P67153 YQFA_ECOLI UPF0073 inner membrane protein YqfA yqfA b2899 JW2867 yqfA 23,847 cytolysis [GO:0019835] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cytolysis [GO:0019835] GO:0005886; GO:0016021; GO:0019835 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76068 YNAK_ECOLI Uncharacterized protein YnaK ynaK b1365 JW1359 ynaK 9,787 +P76091 YNBB_ECOLI Uncharacterized protein YnbB ynbB b1409 JW1406 ynbB 33,054 peptidoglycan-based cell wall biogenesis [GO:0009273] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transferase activity, transferring phosphorus-containing groups [GO:0016772]; peptidoglycan-based cell wall biogenesis [GO:0009273] transferase activity, transferring phosphorus-containing groups [GO:0016772] GO:0005886; GO:0009273; GO:0016021; GO:0016772 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0A8P8 XERD_ECOLI Tyrosine recombinase XerD xerD xprB b2894 JW2862 xprB xerD 34,246 cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; plasmid maintenance [GO:0006276]; resolution of recombination intermediates [GO:0071139]; response to radiation [GO:0009314]; transposition, DNA-mediated [GO:0006313] cytoplasm [GO:0005737]; Holliday junction resolvase complex [GO:0048476] cytoplasm [GO:0005737]; Holliday junction resolvase complex [GO:0048476]; DNA binding [GO:0003677]; site-specific recombinase activity [GO:0009009]; tyrosine-based site-specific recombinase activity [GO:0009037]; cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; plasmid maintenance [GO:0006276]; resolution of recombination intermediates [GO:0071139]; response to radiation [GO:0009314]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; site-specific recombinase activity [GO:0009009]; tyrosine-based site-specific recombinase activity [GO:0009037] GO:0003677; GO:0005737; GO:0006276; GO:0006313; GO:0007049; GO:0007059; GO:0009009; GO:0009037; GO:0009314; GO:0048476; GO:0051301; GO:0071139 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P27242 WAAU_ECOLI Lipopolysaccharide 1,2-N-acetylglucosaminetransferase (EC 2.4.1.56) waaU rfaK waaK b3623 JW3598 rfaK waaK waaU 41,729 lipopolysaccharide biosynthetic process [GO:0009103]; lipopolysaccharide core region biosynthetic process [GO:0009244] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; ADP-heptose-lipopolysaccharide heptosyltransferase activity [GO:0008713]; lipopolysaccharide N-acetylglucosaminyltransferase activity [GO:0008917]; lipopolysaccharide biosynthetic process [GO:0009103]; lipopolysaccharide core region biosynthetic process [GO:0009244] ADP-heptose-lipopolysaccharide heptosyltransferase activity [GO:0008713]; lipopolysaccharide N-acetylglucosaminyltransferase activity [GO:0008917] GO:0005829; GO:0008713; GO:0008917; GO:0009103; GO:0009244; GO:0016020 SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. +P76372 WZZB_ECOLI Chain length determinant protein (Polysaccharide antigen chain regulator) wzzB cld rol wzz b2027 JW5836 cld rol wzz wzzB 36,455 lipopolysaccharide biosynthetic process [GO:0009103] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein tyrosine kinase activity [GO:0004713]; lipopolysaccharide biosynthetic process [GO:0009103] protein tyrosine kinase activity [GO:0004713] GO:0004713; GO:0005886; GO:0009103; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:16079137}. +P75777 YBHG_ECOLI UPF0194 membrane protein YbhG ybhG b0795 JW0779 ybhG 36,416 response to antibiotic [GO:0046677] periplasmic space [GO:0042597]; plasma membrane [GO:0005886] periplasmic space [GO:0042597]; plasma membrane [GO:0005886]; response to antibiotic [GO:0046677] GO:0005886; GO:0042597; GO:0046677 SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_01304, ECO:0000305}. +Q47156 YAFN_ECOLI Antitoxin YafN yafN b0232 JW0222 yafN 11,234 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; negative regulation of molecular function [GO:0044092]; regulation of transcription, DNA-templated [GO:0006355]; SOS response [GO:0009432] DNA binding [GO:0003677]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; negative regulation of molecular function [GO:0044092]; regulation of transcription, DNA-templated [GO:0006355]; SOS response [GO:0009432] DNA binding [GO:0003677] GO:0003677; GO:0006281; GO:0006355; GO:0006974; GO:0009432; GO:0044092 +P28696 YAAI_ECOLI UPF0412 protein YaaI yaaI b0013 JW0012 yaaI 14,482 +P75835 YCAM_ECOLI Inner membrane transporter YcaM ycaM b0899 JW5119 ycaM 52,496 amino acid transport [GO:0006865] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; amino acid transport [GO:0006865] amino acid transmembrane transporter activity [GO:0015171] GO:0005886; GO:0006865; GO:0015171; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77296 YBET_ECOLI Sel1-repeat-containing protein YbeT ybeT b0647 JW0642 ybeT 20,915 protein ubiquitination [GO:0016567]; ubiquitin-dependent ERAD pathway [GO:0030433] protein ubiquitination [GO:0016567]; ubiquitin-dependent ERAD pathway [GO:0030433] GO:0016567; GO:0030433 +P30979 YBEF_ECOLI Uncharacterized HTH-type transcriptional regulator YbeF ybeF b0629 JW0624 ybeF 35,960 regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006355 +P77588 YDEQ_ECOLI Uncharacterized fimbrial-like protein YdeQ ydeQ b1502 JW1496 ydeQ 32,070 cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0009289; GO:0043709; GO:0043711 SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. +P52037 YGFF_ECOLI Uncharacterized oxidoreductase YgfF (EC 1.-.-.-) ygfF yqfD b2902 JW2870 yqfD ygfF 25,938 oxidoreductase activity [GO:0016491] oxidoreductase activity [GO:0016491] GO:0016491 +P76164 YDFW_ECOLI Protein YdfW ydfW intK b1567 JW1559 intK ydfW 5,881 +P60872 YIDE_ECOLI Putative transport protein YidE yidE yibE b3685 JW3662 yibE yidE 58,939 potassium ion transport [GO:0006813] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cation transmembrane transporter activity [GO:0008324]; potassium ion transport [GO:0006813] cation transmembrane transporter activity [GO:0008324] GO:0005886; GO:0006813; GO:0008324; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01016}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01016}. +P76176 YDGD_ECOLI Uncharacterized serine protease YdgD (EC 3.4.21.-) ydgD b1598 JW1590 ydgD 29,277 serine-type endopeptidase activity [GO:0004252] serine-type endopeptidase activity [GO:0004252] GO:0004252 +P76545 YFFN_ECOLI Uncharacterized protein YffN yffN b2445 yffN 13,778 +P76501 YFCR_ECOLI Uncharacterized fimbrial-like protein YfcR yfcR b2335 JW2332 yfcR 17,890 cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0007155; GO:0009289; GO:0043709; GO:0043711 +P31447 YIDJ_ECOLI Uncharacterized sulfatase YidJ (EC 3.1.6.-) yidJ b3678 JW3654 yidJ 57,295 arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872] arylsulfatase activity [GO:0004065]; metal ion binding [GO:0046872] GO:0004065; GO:0046872 +P0ADW3 YHCB_ECOLI Inner membrane protein YhcB yhcB b3233 JW5539 yhcB 14,961 cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] GO:0005829; GO:0005886; GO:0005887 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:21210718}; Single-pass membrane protein {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:21210718}. +P0AF40 YIJD_ECOLI Inner membrane protein YijD yijD b3964 JW3936 yijD 13,024 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305}. +P0ACX9 YDIE_ECOLI Uncharacterized protein YdiE ydiE b1705 JW1695 ydiE 7,117 +P0ACR2 YDHB_ECOLI Uncharacterized HTH-type transcriptional regulator YdhB ydhB b1659 JW1651 ydhB 35,250 regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006355 +P76011 YMGE_ECOLI UPF0410 protein YmgE (Transglycosylase-associated gene protein) ymgE tag b1195 JW1184 tag ymgE 8,775 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P09996 YIDB_ECOLI Uncharacterized protein YidB yidB b3698 JW3675 yidB 13,787 +P76417 YEGT_ECOLI Putative nucleoside transporter YegT yegT b2098 JW2085 yegT 47,359 organic substance transport [GO:0071702] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cytidine transmembrane transporter activity [GO:0015212]; uridine transmembrane transporter activity [GO:0015213]; organic substance transport [GO:0071702] cytidine transmembrane transporter activity [GO:0015212]; uridine transmembrane transporter activity [GO:0015213] GO:0005886; GO:0005887; GO:0015212; GO:0015213; GO:0071702 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76396 YEGL_ECOLI Uncharacterized protein YegL yegL b2073 JW2058 yegL 24,218 +P31826 YDDA_ECOLI Inner membrane ABC transporter ATP-binding protein YddA (CDS102) yddA b1496 JW5242 yddA 64,985 integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626] ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0005887; GO:0016021; GO:0016887; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76063 YDAS_ECOLI Uncharacterized protein YdaS ydaS b1357 JW1352 ydaS 10,976 cell death [GO:0008219] DNA binding [GO:0003677]; cell death [GO:0008219] DNA binding [GO:0003677] GO:0003677; GO:0008219 +P77503 YCJS_ECOLI D-glucoside 3-dehydrogenase (EC 1.1.1.-) ycjS b1315 JW1308 ycjS 38,652 carbohydrate metabolic process [GO:0005975] nucleotide binding [GO:0000166]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; carbohydrate metabolic process [GO:0005975] nucleotide binding [GO:0000166]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] GO:0000166; GO:0005975; GO:0016616 +P0DPM9 YKGV_ECOLI Protein YkgV ykgV b4729 ykgV 8,638 +P52007 YECM_ECOLI Protein YecM yecM yecL b1875 JW5309 yecL yecM 21,205 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P0ADK8 YIBL_ECOLI Uncharacterized protein YibL yibL b3602 JW3577 yibL 13,696 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16980477}. Note=Has been seen to comigrate with the 50S ribosomal subunit in sucrose gradients. +P25714 YIDC_ECOLI Membrane protein insertase YidC (Foldase YidC) (Inner membrane protein YidC) (Membrane integrase YidC) (Oxa1Ec) yidC b3705 JW3683 yidC 61,526 protein-containing complex assembly [GO:0065003]; protein folding [GO:0006457]; protein insertion into membrane [GO:0051205]; protein transport [GO:0015031] cell envelope Sec protein transport complex [GO:0031522]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] cell envelope Sec protein transport complex [GO:0031522]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; membrane insertase activity [GO:0032977]; protein folding [GO:0006457]; protein insertion into membrane [GO:0051205]; protein transport [GO:0015031]; protein-containing complex assembly [GO:0065003] membrane insertase activity [GO:0032977] GO:0005886; GO:0005887; GO:0006457; GO:0015031; GO:0016021; GO:0031522; GO:0032977; GO:0051205; GO:0065003 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:11821429, ECO:0000269|PubMed:16079137}; Multi-pass membrane protein {ECO:0000269|PubMed:11821429, ECO:0000269|PubMed:16079137}. Note=Predominantly localized at cell poles at all stages of cell growth. +P0A710 YCIB_ECOLI Probable intracellular septation protein A yciB ispZ b1254 JW1246 ispZ yciB 20,790 division septum assembly [GO:0000917] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; division septum assembly [GO:0000917] GO:0000917; GO:0005886; GO:0005887 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P0DP22 YJIQ_ECOLI Putative inactive recombination-promoting nuclease-like protein YjiQ yjiQ rpnD b4339 JW4302 rpnD yjiQ 21,769 +P45530 TUSB_ECOLI Protein TusB (tRNA 2-thiouridine synthesizing protein B) tusB yheL b3343 JW3305 yheL tusB 10,718 tRNA wobble position uridine thiolation [GO:0002143] sulfurtransferase complex [GO:1990228] sulfurtransferase complex [GO:1990228]; tRNA wobble position uridine thiolation [GO:0002143] GO:0002143; GO:1990228 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P16525 TUS_ECOLI DNA replication terminus site-binding protein (Ter-binding protein) tus tau b1610 JW1602 tau tus 35,783 DNA replication termination [GO:0006274]; replication fork arrest involved in DNA replication termination [GO:0071807] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; sequence-specific DNA binding [GO:0043565]; DNA replication termination [GO:0006274]; replication fork arrest involved in DNA replication termination [GO:0071807] sequence-specific DNA binding [GO:0043565] GO:0005737; GO:0006274; GO:0043565; GO:0071807 SUBCELLULAR LOCATION: Cytoplasm. +P0AA97 YAEQ_ECOLI Uncharacterized protein YaeQ yaeQ b0190 JW0186 yaeQ 20,877 +P0AB06 YCBK_ECOLI Uncharacterized protein YcbK ycbK b0926 JW0909 ycbK 20,354 peptidoglycan turnover [GO:0009254] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; endopeptidase activity [GO:0004175]; peptidoglycan turnover [GO:0009254] endopeptidase activity [GO:0004175] GO:0004175; GO:0009254; GO:0030288 +P77354 YAFU_ECOLI Putative inner membrane protein YafU yafU b0218 JW0207 yafU 12,136 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein. Note=When overexpressed using vectors that provide a promoter and ribosome binding site (PubMed:15919996). {ECO:0000269|PubMed:15919996}. +P0AAN5 YAIA_ECOLI Uncharacterized protein YaiA yaiA b0389 JW0380 yaiA 7,281 +P39830 YBAL_ECOLI Putative cation/proton antiporter YbaL ybaL ylaA b0478 JW0467 ylaA ybaL 59,424 potassium ion transport [GO:0006813] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; nucleotide binding [GO:0000166]; solute:proton antiporter activity [GO:0015299]; potassium ion transport [GO:0006813] nucleotide binding [GO:0000166]; solute:proton antiporter activity [GO:0015299] GO:0000166; GO:0005886; GO:0006813; GO:0015299; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000305|PubMed:15919996}. +P0DP63 YBEH_ECOLI Putative protein YbeH ybeH b4581 JW0620 b0625 ybeH 7,969 +P0A8H8 YACG_ECOLI DNA gyrase inhibitor YacG yacG b0101 JW5008 yacG 7,306 regulation of transcription, DNA-templated [GO:0006355] DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity [GO:0008657]; zinc ion binding [GO:0008270]; regulation of transcription, DNA-templated [GO:0006355] DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity [GO:0008657]; zinc ion binding [GO:0008270] GO:0006355; GO:0008270; GO:0008657 +P37325 YBCH_ECOLI Uncharacterized protein YbcH ybcH b0567 JW0556 ybcH 33,057 +P24178 YFFB_ECOLI Protein YffB yffB b2471 JW2455 yffB 13,601 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P77375 YDHX_ECOLI Uncharacterized ferredoxin-like protein YdhX ydhX b1671 JW5271 ydhX 25,093 outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0030288; GO:0046872; GO:0051539 +P52127 YFJL_ECOLI Uncharacterized protein YfjL yfjL b2628 JW2609 yfjL 62,007 defense response to virus [GO:0051607] nuclease activity [GO:0004518]; nucleotide binding [GO:0000166]; defense response to virus [GO:0051607] nuclease activity [GO:0004518]; nucleotide binding [GO:0000166] GO:0000166; GO:0004518; GO:0051607 +P76035 YCIW_ECOLI Uncharacterized protein YciW yciW b1287 JW5200 yciW 42,220 +P08245 YCIH_ECOLI Uncharacterized protein YciH yciH b1282 JW1274 yciH 11,396 formation of translation preinitiation complex [GO:0001731]; translation reinitiation [GO:0002188] mRNA binding [GO:0003729]; ribosomal small subunit binding [GO:0043024]; translation initiation factor activity [GO:0003743]; formation of translation preinitiation complex [GO:0001731]; translation reinitiation [GO:0002188] mRNA binding [GO:0003729]; ribosomal small subunit binding [GO:0043024]; translation initiation factor activity [GO:0003743] GO:0001731; GO:0002188; GO:0003729; GO:0003743; GO:0043024 +Q46796 YGEP_ECOLI Putative protein YgeP ygeP b2862 JW2831 ygeP 11,291 +P76076 YDBL_ECOLI Uncharacterized protein YdbL ydbL b1383 JW5216 ydbL 11,878 +P0AFR4 YCIO_ECOLI Uncharacterized protein YciO yciO b1267 JW5196 yciO 23,212 cytosol [GO:0005829] cytosol [GO:0005829]; double-stranded RNA binding [GO:0003725] double-stranded RNA binding [GO:0003725] GO:0003725; GO:0005829 +P77716 YCJP_ECOLI Inner membrane ABC transporter permease protein YcjP ycjP b1312 JW1305 ycjP 31,250 transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transport [GO:0055085] GO:0005886; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AAL9 YKGJ_ECOLI Uncharacterized protein YkgJ ykgJ b0288 JW0282 ykgJ 11,798 iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872] iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872] GO:0046872; GO:0051536 +P64490 YOAC_ECOLI Uncharacterized protein YoaC yoaC b1810 JW5296 yoaC 10,835 +P56256 YSAA_ECOLI Putative electron transport protein YsaA ysaA b3573 JW3545 ysaA 17,459 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] GO:0009055; GO:0046872; GO:0051539 +P76208 YNIB_ECOLI Uncharacterized protein YniB yniB b1726 JW1715 yniB 20,367 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P76093 YNBD_ECOLI Uncharacterized protein YnbD ynbD b1411 JW1408 ynbD 49,563 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138] protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein tyrosine phosphatase activity [GO:0004725] GO:0004725; GO:0005886; GO:0008138; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +Q47710 YQJK_ECOLI Uncharacterized protein YqjK yqjK b3100 JW3071 yqjK 11,811 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P22524 MUKE_ECOLI Chromosome partition protein MukE (Protein KicA) mukE kicA ycbA b0923 JW0906 kicA ycbA mukE 26,974 cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome condensation [GO:0030261]; chromosome segregation [GO:0007059]; DNA replication [GO:0006260] cytoplasm [GO:0005737]; nucleoid [GO:0009295] cytoplasm [GO:0005737]; nucleoid [GO:0009295]; cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome condensation [GO:0030261]; chromosome segregation [GO:0007059]; DNA replication [GO:0006260] GO:0005737; GO:0006260; GO:0007049; GO:0007059; GO:0009295; GO:0030261; GO:0051301 SUBCELLULAR LOCATION: Cytoplasm, nucleoid. Note=Restricted to the nucleoid region. +P43337 NUDL_ECOLI Uncharacterized Nudix hydrolase NudL (EC 3.6.1.-) nudL yeaB b1813 JW1802 yeaB nudL 21,436 nucleoside diphosphate metabolic process [GO:0009132] hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nucleoside diphosphate metabolic process [GO:0009132] hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145] GO:0000287; GO:0009132; GO:0016818; GO:0030145 +P0A9N8 NRDG_ECOLI Anaerobic ribonucleoside-triphosphate reductase-activating protein (EC 1.97.1.-) (Class III anaerobic ribonucleotide reductase small component) nrdG yjgE b4237 JW4196 yjgE nrdG 17,446 nucleobase-containing small molecule interconversion [GO:0015949] anaerobic ribonucleoside-triphosphate reductase complex [GO:0031250] anaerobic ribonucleoside-triphosphate reductase complex [GO:0031250]; 4 iron, 4 sulfur cluster binding [GO:0051539]; [formate-C-acetyltransferase]-activating enzyme activity [GO:0043365]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; nucleobase-containing small molecule interconversion [GO:0015949] [formate-C-acetyltransferase]-activating enzyme activity [GO:0043365]; 4 iron, 4 sulfur cluster binding [GO:0051539]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872] GO:0015949; GO:0031250; GO:0043365; GO:0046872; GO:0051536; GO:0051539 SUBCELLULAR LOCATION: Cytoplasm. +P0A7A7 PLSB_ECOLI Glycerol-3-phosphate acyltransferase (GPAT) (EC 2.3.1.15) plsB b4041 JW4001 plsB 91,381 CDP-diacylglycerol biosynthetic process [GO:0016024]; fatty acid metabolic process [GO:0006631]; glycerol-3-phosphate metabolic process [GO:0006072]; phospholipid biosynthetic process [GO:0008654]; triglyceride biosynthetic process [GO:0019432] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity [GO:0102420]; CDP-diacylglycerol biosynthetic process [GO:0016024]; fatty acid metabolic process [GO:0006631]; glycerol-3-phosphate metabolic process [GO:0006072]; phospholipid biosynthetic process [GO:0008654]; triglyceride biosynthetic process [GO:0019432] glycerol-3-phosphate O-acyltransferase activity [GO:0004366]; sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity [GO:0102420] GO:0004366; GO:0005886; GO:0005887; GO:0006072; GO:0006631; GO:0008654; GO:0016024; GO:0019432; GO:0102420 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16294310, ECO:0000269|PubMed:4943977}; Peripheral membrane protein {ECO:0000269|PubMed:16294310, ECO:0000269|PubMed:4943977}; Cytoplasmic side {ECO:0000269|PubMed:16294310, ECO:0000269|PubMed:4943977}. +P37619 QPTR_ECOLI Queuosine precursor transporter (Q precursor transporter) yhhQ b3471 JW3436 yhhQ 25,269 pyrimidine-containing compound transmembrane transport [GO:0072531]; queuosine salvage [GO:1990397] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; pyrimidine-containing compound transmembrane transport [GO:0072531]; queuosine salvage [GO:1990397] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0022857; GO:0072531; GO:1990397 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02088, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02088}. +P04993 RECD_ECOLI RecBCD enzyme subunit RecD (EC 3.1.11.5) (Exodeoxyribonuclease V 67 kDa polypeptide) (Exodeoxyribonuclease V alpha chain) (Exonuclease V subunit RecD) (ExoV subunit RecD) (Helicase/nuclease RecBCD subunit RecD) recD hopE b2819 JW2787 hopE recD 66,902 cellular response to DNA damage stimulus [GO:0006974]; DNA recombination [GO:0006310]; double-strand break repair via homologous recombination [GO:0000724] exodeoxyribonuclease V complex [GO:0009338] exodeoxyribonuclease V complex [GO:0009338]; 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; exodeoxyribonuclease V activity [GO:0008854]; helicase activity [GO:0004386]; single-stranded DNA helicase activity [GO:0017116]; cellular response to DNA damage stimulus [GO:0006974]; DNA recombination [GO:0006310]; double-strand break repair via homologous recombination [GO:0000724] 5'-3' DNA helicase activity [GO:0043139]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; exodeoxyribonuclease V activity [GO:0008854]; helicase activity [GO:0004386]; single-stranded DNA helicase activity [GO:0017116] GO:0000724; GO:0003677; GO:0004386; GO:0005524; GO:0006310; GO:0006974; GO:0008854; GO:0009338; GO:0017116; GO:0043139 +P37624 RBBA_ECOLI Ribosome-associated ATPase (Ribosomal bound ATPase) rbbA yhiG yhiH b3486 JW5676 yhiG yhiH rbbA 100,785 positive regulation of translation [GO:0045727] ATP-binding cassette (ABC) transporter complex [GO:0043190]; cell pole [GO:0060187]; cytosolic small ribosomal subunit [GO:0022627]; membrane [GO:0016020]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; cell pole [GO:0060187]; cytosolic small ribosomal subunit [GO:0022627]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ribosomal small subunit binding [GO:0043024]; positive regulation of translation [GO:0045727] ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; ribosomal small subunit binding [GO:0043024] GO:0005524; GO:0005886; GO:0016020; GO:0016887; GO:0022627; GO:0042626; GO:0043024; GO:0043190; GO:0045727; GO:0060187 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:21556145}; Multi-pass membrane protein {ECO:0000255}. +P13857 RIML_ECOLI Ribosomal-protein-serine acetyltransferase (EC 2.3.1.-) (Acetylating enzyme for N-terminal of ribosomal protein L7/L12) rimL b1427 JW1423 rimL 20,681 cellular protein modification process [GO:0006464]; N-terminal peptidyl-serine acetylation [GO:0017198]; N-terminal protein amino acid acetylation [GO:0006474] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; N-acetyltransferase activity [GO:0008080]; peptide alpha-N-acetyltransferase activity [GO:0004596]; peptide-serine-N-acetyltransferase activity [GO:1990189]; ribosomal-protein-alanine N-acetyltransferase activity [GO:0008999]; cellular protein modification process [GO:0006464]; N-terminal peptidyl-serine acetylation [GO:0017198]; N-terminal protein amino acid acetylation [GO:0006474] N-acetyltransferase activity [GO:0008080]; peptide alpha-N-acetyltransferase activity [GO:0004596]; peptide-serine-N-acetyltransferase activity [GO:1990189]; ribosomal-protein-alanine N-acetyltransferase activity [GO:0008999] GO:0004596; GO:0005737; GO:0006464; GO:0006474; GO:0008080; GO:0008999; GO:0017198; GO:1990189 SUBCELLULAR LOCATION: Cytoplasm. +P77732 RHMR_ECOLI Uncharacterized HTH-type transcriptional regulator RhmR rhmR yfaX b2248 JW2242 yfaX rhmR 28,904 negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0045892 +P75864 RLMKL_ECOLI Ribosomal RNA large subunit methyltransferase K/L [Includes: 23S rRNA m2G2445 methyltransferase (EC 2.1.1.173) (rRNA (guanine-N(2)-)-methyltransferase RlmL); 23S rRNA m7G2069 methyltransferase (EC 2.1.1.264) (rRNA (guanine-N(7)-)-methyltransferase RlmK)] rlmL rlmK rlmKL ycbY b0948 JW0931 rlmK rlmKL ycbY rlmL 78,854 rRNA base methylation [GO:0070475]; rRNA methylation [GO:0031167] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 23S rRNA (guanine(2445)-N(2))-methyltransferase activity [GO:0052915]; RNA binding [GO:0003723]; rRNA (guanine-N2-)-methyltransferase activity [GO:0008990]; rRNA (guanine-N7-)-methyltransferase activity [GO:0070043]; rRNA base methylation [GO:0070475]; rRNA methylation [GO:0031167] 23S rRNA (guanine(2445)-N(2))-methyltransferase activity [GO:0052915]; RNA binding [GO:0003723]; rRNA (guanine-N2-)-methyltransferase activity [GO:0008990]; rRNA (guanine-N7-)-methyltransferase activity [GO:0070043] GO:0003723; GO:0005737; GO:0008990; GO:0031167; GO:0052915; GO:0070043; GO:0070475 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AG71 RMUC_ECOLI DNA recombination protein RmuC rmuC yigN b3832 JW3809 yigN rmuC 54,764 DNA recombination [GO:0006310] DNA recombination [GO:0006310] GO:0006310 +P61887 RMLA2_ECOLI Glucose-1-phosphate thymidylyltransferase 2 (G1P-TT 2) (EC 2.7.7.24) (dTDP-glucose pyrophosphorylase 2) (dTDP-glucose synthase 2) rffH rmlA2 yifG b3789 JW3763 rmlA2 yifG rffH 32,734 enterobacterial common antigen biosynthetic process [GO:0009246]; extracellular polysaccharide biosynthetic process [GO:0045226] cytosol [GO:0005829] cytosol [GO:0005829]; glucose-1-phosphate thymidylyltransferase activity [GO:0008879]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; enterobacterial common antigen biosynthetic process [GO:0009246]; extracellular polysaccharide biosynthetic process [GO:0045226] glucose-1-phosphate thymidylyltransferase activity [GO:0008879]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287] GO:0000287; GO:0005829; GO:0008879; GO:0009246; GO:0042802; GO:0045226 +P15288 PEPD_ECOLI Cytosol non-specific dipeptidase (EC 3.4.13.18) (Aminoacyl-histidine dipeptidase) (Beta-alanyl-histidine dipeptidase) (Carnosinase) (Cysteinylglycinase) (Peptidase D) (Xaa-His dipeptidase) (X-His dipeptidase) pepD pepH b0237 JW0227 pepH pepD 52,915 peptide catabolic process [GO:0043171] cytosol [GO:0005829] cytosol [GO:0005829]; alanylglutamate dipeptidase activity [GO:0103046]; dipeptidase activity [GO:0016805]; metallodipeptidase activity [GO:0070573]; zinc ion binding [GO:0008270]; peptide catabolic process [GO:0043171] alanylglutamate dipeptidase activity [GO:0103046]; dipeptidase activity [GO:0016805]; metallodipeptidase activity [GO:0070573]; zinc ion binding [GO:0008270] GO:0005829; GO:0008270; GO:0016805; GO:0043171; GO:0070573; GO:0103046 +G3MTW7 PMRR_ECOLI Putative membrane protein PmrR pmrR b4703 JW4072.1 pmrR 3,465 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P21165 PEPQ_ECOLI Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Proline dipeptidase) (Prolidase) pepQ b3847 JW3823 pepQ 50,176 peptide catabolic process [GO:0043171] cytosol [GO:0005829] cytosol [GO:0005829]; aminopeptidase activity [GO:0004177]; dipeptidase activity [GO:0016805]; manganese ion binding [GO:0030145]; metallodipeptidase activity [GO:0070573]; peptidase activity [GO:0008233]; phosphoric triester hydrolase activity [GO:0016795]; proline dipeptidase activity [GO:0102009]; peptide catabolic process [GO:0043171] aminopeptidase activity [GO:0004177]; dipeptidase activity [GO:0016805]; manganese ion binding [GO:0030145]; metallodipeptidase activity [GO:0070573]; peptidase activity [GO:0008233]; phosphoric triester hydrolase activity [GO:0016795]; proline dipeptidase activity [GO:0102009] GO:0004177; GO:0005829; GO:0008233; GO:0016795; GO:0016805; GO:0030145; GO:0043171; GO:0070573; GO:0102009 +P09378 RHAR_ECOLI HTH-type transcriptional activator RhaR (L-rhamnose operon transcriptional activator RhaR) rhaR rhaC1 b3906 JW3877 rhaC1 rhaR 32,373 positive regulation of transcription, DNA-templated [GO:0045893]; rhamnose metabolic process [GO:0019299]; transcription, DNA-templated [GO:0006351] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; positive regulation of transcription, DNA-templated [GO:0045893]; rhamnose metabolic process [GO:0019299]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0005737; GO:0006351; GO:0019299; GO:0043565; GO:0045893 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01533}. +P0A8J8 RHLB_ECOLI ATP-dependent RNA helicase RhlB (EC 3.6.4.13) rhlB mmrA b3780 JW3753 mmrA rhlB 47,126 RNA catabolic process [GO:0006401] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; disordered domain specific binding [GO:0097718]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724]; RNA catabolic process [GO:0006401] ATP binding [GO:0005524]; disordered domain specific binding [GO:0097718]; RNA binding [GO:0003723]; RNA helicase activity [GO:0003724] GO:0003723; GO:0003724; GO:0005524; GO:0005829; GO:0006401; GO:0097718 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00661, ECO:0000269|PubMed:18337249}. Note=Forms a cytoskeletal-like coiled structure that extends along the length of the cell. Formation of this structure does not require the presence of RNase E, MinD and/or MreB. +P0C077 RELE_ECOLI mRNA interferase toxin RelE (EC 3.1.-.-) (Endoribonuclease RelE) (Toxin RelE) relE b1563 JW1555 relE 11,225 cellular response to amino acid starvation [GO:0034198]; mRNA catabolic process [GO:0006402]; negative regulation of translation [GO:0017148]; response to antibiotic [GO:0046677] protein-DNA complex [GO:0032993] protein-DNA complex [GO:0032993]; DNA-binding transcription repressor activity [GO:0001217]; endoribonuclease activity [GO:0004521]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; cellular response to amino acid starvation [GO:0034198]; mRNA catabolic process [GO:0006402]; negative regulation of translation [GO:0017148]; response to antibiotic [GO:0046677] DNA-binding transcription repressor activity [GO:0001217]; endoribonuclease activity [GO:0004521]; ribosome binding [GO:0043022]; rRNA binding [GO:0019843]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0001217; GO:0004521; GO:0006402; GO:0017148; GO:0019843; GO:0032993; GO:0034198; GO:0043022; GO:0046677 +P08372 PPDC_ECOLI Prepilin peptidase-dependent protein C ppdC ygdA b2823 JW2791 ygdA ppdC 12,004 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021] GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. +P0AFL6 PPX_ECOLI Exopolyphosphatase (ExopolyPase) (EC 3.6.1.11) (Metaphosphatase) ppx b2502 JW2487 ppx 58,136 phosphorus metabolic process [GO:0006793]; polyphosphate catabolic process [GO:0006798] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; exopolyphosphatase activity [GO:0004309]; identical protein binding [GO:0042802]; pyrophosphatase activity [GO:0016462]; phosphorus metabolic process [GO:0006793]; polyphosphate catabolic process [GO:0006798] exopolyphosphatase activity [GO:0004309]; identical protein binding [GO:0042802]; pyrophosphatase activity [GO:0016462] GO:0004309; GO:0005886; GO:0006793; GO:0006798; GO:0016462; GO:0042802 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:8380170}; Peripheral membrane protein {ECO:0000305|PubMed:8380170}. +P0ADY1 PPID_ECOLI Periplasmic chaperone PpiD (Periplasmic folding chaperone) ppiD ybaU b0441 JW0431 ybaU ppiD 68,150 chaperone-mediated protein folding [GO:0061077] integral component of external side of plasma membrane [GO:0071575] integral component of external side of plasma membrane [GO:0071575]; identical protein binding [GO:0042802]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; chaperone-mediated protein folding [GO:0061077] identical protein binding [GO:0042802]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755] GO:0003755; GO:0042802; GO:0061077; GO:0071575 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:21210718, ECO:0000269|PubMed:9670013}; Single-pass type II membrane protein {ECO:0000269|PubMed:21210718, ECO:0000269|PubMed:9670013}; Periplasmic side {ECO:0000269|PubMed:21210718, ECO:0000269|PubMed:9670013}. Note=Located at the lateral gate of SecY. {ECO:0000269|PubMed:24951590}. +P19642 PTOCB_ECOLI PTS system maltose-specific EIICB component [Includes: Maltose permease IIC component (PTS system maltose-specific EIIC component); Maltose-specific phosphotransferase enzyme IIB component (EC 2.7.1.208) (PTS system maltose-specific EIIB component)] malX b1621 JW1613 malX 56,627 carbohydrate utilization [GO:0009758]; glucose transmembrane transport [GO:1904659]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-glucose phosphotransferase system transporter activity [GO:0090564]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; carbohydrate utilization [GO:0009758]; glucose transmembrane transport [GO:1904659]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-glucose phosphotransferase system transporter activity [GO:0090564]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005886; GO:0005887; GO:0008982; GO:0009401; GO:0009758; GO:0016301; GO:0090563; GO:0090564; GO:1904659 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00426, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00426, ECO:0000269|PubMed:15919996}. +P0A9J6 RBSK_ECOLI Ribokinase (RK) (EC 2.7.1.15) rbsK b3752 JW3731 rbsK 32,291 D-ribose catabolic process [GO:0019303] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; ribokinase activity [GO:0004747]; D-ribose catabolic process [GO:0019303] ATP binding [GO:0005524]; metal ion binding [GO:0046872]; ribokinase activity [GO:0004747] GO:0004747; GO:0005524; GO:0005829; GO:0019303; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01987, ECO:0000305}. +P0AG20 RELA_ECOLI GTP pyrophosphokinase (EC 2.7.6.5) ((p)ppGpp synthase) (ATP:GTP 3'-pyrophosphotransferase) (ppGpp synthase I) relA b2784 JW2755 relA 83,876 guanosine tetraphosphate biosynthetic process [GO:0015970]; guanosine tetraphosphate metabolic process [GO:0015969]; nucleobase-containing small molecule interconversion [GO:0015949]; response to starvation [GO:0042594] ATP binding [GO:0005524]; GTP binding [GO:0005525]; GTP diphosphokinase activity [GO:0008728]; guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity [GO:0008893]; kinase activity [GO:0016301]; guanosine tetraphosphate biosynthetic process [GO:0015970]; guanosine tetraphosphate metabolic process [GO:0015969]; nucleobase-containing small molecule interconversion [GO:0015949]; response to starvation [GO:0042594] ATP binding [GO:0005524]; GTP binding [GO:0005525]; GTP diphosphokinase activity [GO:0008728]; guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity [GO:0008893]; kinase activity [GO:0016301] GO:0005524; GO:0005525; GO:0008728; GO:0008893; GO:0015949; GO:0015969; GO:0015970; GO:0016301; GO:0042594 +P30015 LHR_ECOLI Probable ATP-dependent helicase lhr (EC 3.6.4.-) (Large helicase-related protein) lhr rhlF b1653 JW1645 rhlF lhr 169,381 ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; nucleic acid binding [GO:0003676] ATP binding [GO:0005524]; helicase activity [GO:0004386]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; nucleic acid binding [GO:0003676] GO:0003676; GO:0004386; GO:0005524; GO:0016818 +P0A734 MINE_ECOLI Cell division topological specificity factor minE b1174 JW1163 minE 10,235 division septum site selection [GO:0000918]; regulation of cell division [GO:0051302]; regulation of division septum assembly [GO:0032955] cytosol [GO:0005829]; plasma membrane [GO:0005886] cytosol [GO:0005829]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; division septum site selection [GO:0000918]; regulation of cell division [GO:0051302]; regulation of division septum assembly [GO:0032955] identical protein binding [GO:0042802] GO:0000918; GO:0005829; GO:0005886; GO:0032955; GO:0042802; GO:0051302 +P77567 NHOA_ECOLI Arylamine N-acetyltransferase (EC 2.3.1.5) (Arylhydroxamate N,O-acetyltransferase) (N-hydroxyarylamine O-acetyltransferase) (EC 2.3.1.118) nhoA yddI b1463 JW1458 yddI nhoA 32,275 cytoplasm [GO:0005737] cytoplasm [GO:0005737]; arylamine N-acetyltransferase activity [GO:0004060]; N-hydroxyarylamine O-acetyltransferase activity [GO:0046990] arylamine N-acetyltransferase activity [GO:0004060]; N-hydroxyarylamine O-acetyltransferase activity [GO:0046990] GO:0004060; GO:0005737; GO:0046990 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q00267}. +Q46891 OTNI_ECOLI 2-oxo-tetronate isomerase (EC 5.3.1.35) (2-dehydrotetronate isomerase) (Glyoxylate-induced protein YgbM) otnI ygbM b2739 JW2709 ygbM otnI 29,217 carbohydrate metabolic process [GO:0005975]; glyoxylate metabolic process [GO:0046487] hydroxypyruvate isomerase activity [GO:0008903]; metal ion binding [GO:0046872]; carbohydrate metabolic process [GO:0005975]; glyoxylate metabolic process [GO:0046487] hydroxypyruvate isomerase activity [GO:0008903]; metal ion binding [GO:0046872] GO:0005975; GO:0008903; GO:0046487; GO:0046872 +P00490 PHSM_ECOLI Maltodextrin phosphorylase (EC 2.4.1.1) malP b3417 JW5689 malP 90,522 alpha-glucan catabolic process [GO:0030980]; glycogen catabolic process [GO:0005980] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; glycogen phosphorylase activity [GO:0008184]; linear malto-oligosaccharide phosphorylase activity [GO:0102250]; maltodextrin phosphorylase activity [GO:0031220]; pyridoxal phosphate binding [GO:0030170]; SHG alpha-glucan phosphorylase activity [GO:0102499]; alpha-glucan catabolic process [GO:0030980]; glycogen catabolic process [GO:0005980] glycogen phosphorylase activity [GO:0008184]; linear malto-oligosaccharide phosphorylase activity [GO:0102250]; maltodextrin phosphorylase activity [GO:0031220]; pyridoxal phosphate binding [GO:0030170]; SHG alpha-glucan phosphorylase activity [GO:0102499] GO:0005737; GO:0005829; GO:0005980; GO:0008184; GO:0030170; GO:0030980; GO:0031220; GO:0102250; GO:0102499 +P0A7N9 RL33_ECOLI 50S ribosomal protein L33 (Large ribosomal subunit protein bL33) rpmG b3636 JW3611 rpmG 6,372 response to antibiotic [GO:0046677]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934] cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit [GO:0015934]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049]; response to antibiotic [GO:0046677]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049] GO:0000027; GO:0000049; GO:0003735; GO:0005829; GO:0006412; GO:0015934; GO:0022625; GO:0046677 +P0ADR6 RLMM_ECOLI Ribosomal RNA large subunit methyltransferase M (EC 2.1.1.186) (23S rRNA (cytidine2498-2'-O)-methyltransferase) (23S rRNA 2'-O-ribose methyltransferase RlmM) rlmM ygdE b2806 JW2777 b1976 ygdE rlmM 41,905 enzyme-directed rRNA 2'-O-methylation [GO:0000453] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; rRNA (cytosine-2'-O-)-methyltransferase activity [GO:0070677]; enzyme-directed rRNA 2'-O-methylation [GO:0000453] rRNA (cytosine-2'-O-)-methyltransferase activity [GO:0070677] GO:0000453; GO:0005737; GO:0070677 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0ACI0 ROB_ECOLI Right origin-binding protein rob b4396 JW4359 rob 33,145 cytosol [GO:0005829] cytosol [GO:0005829]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0005829; GO:0043565 +P12281 MOEA_ECOLI Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) moeA bisB chlE narE b0827 JW0811 bisB chlE narE moeA 44,067 molybdenum incorporation into molybdenum-molybdopterin complex [GO:0018315]; molybdopterin cofactor biosynthetic process [GO:0032324]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molybdopterin adenylyltransferase activity [GO:0061598]; molybdopterin molybdotransferase activity [GO:0061599]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdenum incorporation into molybdenum-molybdopterin complex [GO:0018315]; molybdopterin cofactor biosynthetic process [GO:0032324] identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; molybdopterin adenylyltransferase activity [GO:0061598]; molybdopterin molybdotransferase activity [GO:0061599] GO:0005737; GO:0005829; GO:0006777; GO:0018315; GO:0032324; GO:0042802; GO:0046872; GO:0061598; GO:0061599 +P23842 PDEA_ECOLI Probable cyclic di-GMP phosphodiesterase PdeA (EC 3.1.4.52) pdeA yfeA b2395 JW5391 yfeA pdeA 83,524 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cyclic-guanylate-specific phosphodiesterase activity [GO:0071111] cyclic-guanylate-specific phosphodiesterase activity [GO:0071111] GO:0005886; GO:0016021; GO:0071111 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P37649 PDEK_ECOLI Probable cyclic di-GMP phosphodiesterase PdeK (EC 3.1.4.52) pdeK yhjK b3529 JW5943 yhjK pdeK 74,381 signal transduction [GO:0007165] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cyclic-guanylate-specific phosphodiesterase activity [GO:0071111]; signal transduction [GO:0007165] cyclic-guanylate-specific phosphodiesterase activity [GO:0071111] GO:0005886; GO:0007165; GO:0016021; GO:0071111 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P42588 PAT_ECOLI Putrescine aminotransferase (PAT) (PATase) (EC 2.6.1.82) (Cadaverine transaminase) (Diamine transaminase) (EC 2.6.1.29) (Putrescine transaminase) (Putrescine--2-oxoglutaric acid transaminase) (Putrescine:2-OG aminotransferase) patA ygjG b3073 JW5510 ygjG patA 49,661 L-lysine catabolic process [GO:0019477]; putrescine catabolic process [GO:0009447] cytosol [GO:0005829] cytosol [GO:0005829]; butane-1,4-diamine:2-oxoglutarate aminotransferase activity [GO:0033094]; diamine transaminase activity [GO:0019161]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170]; L-lysine catabolic process [GO:0019477]; putrescine catabolic process [GO:0009447] butane-1,4-diamine:2-oxoglutarate aminotransferase activity [GO:0033094]; diamine transaminase activity [GO:0019161]; identical protein binding [GO:0042802]; pyridoxal phosphate binding [GO:0030170] GO:0005829; GO:0009447; GO:0019161; GO:0019477; GO:0030170; GO:0033094; GO:0042802 +P32169 RHAD_ECOLI Rhamnulose-1-phosphate aldolase (EC 4.1.2.19) rhaD rhuA b3902 JW3873 rhuA rhaD 30,145 pentose catabolic process [GO:0019323]; rhamnose catabolic process [GO:0019301] cytosol [GO:0005829] cytosol [GO:0005829]; aldehyde-lyase activity [GO:0016832]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; rhamnulose-1-phosphate aldolase activity [GO:0008994]; pentose catabolic process [GO:0019323]; rhamnose catabolic process [GO:0019301] aldehyde-lyase activity [GO:0016832]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; rhamnulose-1-phosphate aldolase activity [GO:0008994] GO:0005829; GO:0008994; GO:0016832; GO:0019301; GO:0019323; GO:0042802; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm. +P08371 PPDB_ECOLI Prepilin peptidase-dependent protein B ppdB ygdC b2825 JW5451 ygdC ppdB 20,520 protein secretion by the type II secretion system [GO:0015628] integral component of membrane [GO:0016021] integral component of membrane [GO:0016021]; protein secretion by the type II secretion system [GO:0015628] GO:0015628; GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. +P0ADR8 PPNN_ECOLI Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase (EC 3.2.2.-) (EC 3.2.2.10) (AMP nucleosidase) (EC 3.2.2.4) (CMP nucleosidase) (GMP nucleosidase) (IMP nucleosidase) (UMP nucleosidase) (dTMP nucleosidase) ppnN ygdH b2795 JW2766 ygdH ppnN 50,972 protein homotetramerization [GO:0051289] cytosol [GO:0005829] cytosol [GO:0005829]; AMP nucleosidase activity [GO:0008714]; guanosine tetraphosphate binding [GO:0097216]; identical protein binding [GO:0042802]; inosinate nucleosidase activity [GO:0047723]; pyrimidine-5'-nucleotide nucleosidase activity [GO:0047405]; protein homotetramerization [GO:0051289] AMP nucleosidase activity [GO:0008714]; guanosine tetraphosphate binding [GO:0097216]; identical protein binding [GO:0042802]; inosinate nucleosidase activity [GO:0047723]; pyrimidine-5'-nucleotide nucleosidase activity [GO:0047405] GO:0005829; GO:0008714; GO:0042802; GO:0047405; GO:0047723; GO:0051289; GO:0097216 +P64578 HIGB_ECOLI mRNA interferase toxin HigB (EC 3.1.-.-) (Endoribonuclease HigB) (Toxin HigB) higB ygjN b3083 JW3054 ygjN higB 12,103 negative regulation of translation [GO:0017148]; regulation of mRNA stability [GO:0043488] endoribonuclease activity [GO:0004521]; RNA binding [GO:0003723]; negative regulation of translation [GO:0017148]; regulation of mRNA stability [GO:0043488] endoribonuclease activity [GO:0004521]; RNA binding [GO:0003723] GO:0003723; GO:0004521; GO:0017148; GO:0043488 +P22729 LIVM_ECOLI High-affinity branched-chain amino acid transport system permease protein LivM (LIV-I protein M) livM b3456 JW3421 livM 46,269 branched-chain amino acid transport [GO:0015803]; isoleucine transmembrane transport [GO:1903714]; L-valine transmembrane transport [GO:1903785]; phenylalanine transport [GO:0015823] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; branched-chain amino acid transmembrane transporter activity [GO:0015658]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-phenylalanine transmembrane transporter activity [GO:0015192]; L-valine transmembrane transporter activity [GO:0005304]; branched-chain amino acid transport [GO:0015803]; isoleucine transmembrane transport [GO:1903714]; L-valine transmembrane transport [GO:1903785]; phenylalanine transport [GO:0015823] branched-chain amino acid transmembrane transporter activity [GO:0015658]; L-isoleucine transmembrane transporter activity [GO:0015188]; L-phenylalanine transmembrane transporter activity [GO:0015192]; L-valine transmembrane transporter activity [GO:0005304] GO:0005304; GO:0005886; GO:0005887; GO:0015188; GO:0015192; GO:0015658; GO:0015803; GO:0015823; GO:1903714; GO:1903785 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P25772 LIGB_ECOLI DNA ligase B (EC 6.5.1.2) (Polydeoxyribonucleotide synthase [NAD(+)] B) ligB yicF b3647 JW3622 yicF ligB 63,179 base-excision repair, DNA ligation [GO:0006288]; DNA ligation [GO:0006266]; DNA ligation involved in DNA repair [GO:0051103]; DNA replication [GO:0006260] cytosol [GO:0005829] cytosol [GO:0005829]; DNA ligase (NAD+) activity [GO:0003911]; base-excision repair, DNA ligation [GO:0006288]; DNA ligation [GO:0006266]; DNA ligation involved in DNA repair [GO:0051103]; DNA replication [GO:0006260] DNA ligase (NAD+) activity [GO:0003911] GO:0003911; GO:0005829; GO:0006260; GO:0006266; GO:0006288; GO:0051103 +P37677 LYXK_ECOLI L-xylulose/3-keto-L-gulonate kinase (L-xylulokinase) (EC 2.7.1.-) (EC 2.7.1.53) (3-dehydro-L-gulonate kinase) lyx lyxK sgbK xylK yiaP b3580 JW3552 lyxK sgbK xylK yiaP lyx 55,155 L-lyxose metabolic process [GO:0019324] ATP binding [GO:0005524]; L-xylulokinase activity [GO:0008744]; L-lyxose metabolic process [GO:0019324] ATP binding [GO:0005524]; L-xylulokinase activity [GO:0008744] GO:0005524; GO:0008744; GO:0019324 +P0AAX6 MCBA_ECOLI Uncharacterized protein McbA (MqsR-controlled colanic acid and biofilm protein A) mcbA ybiM b0806 JW5106 ybiM mcbA 8,896 colanic acid biosynthetic process [GO:0009242] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; colanic acid biosynthetic process [GO:0009242] GO:0009242; GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P30958 MFD_ECOLI Transcription-repair-coupling factor (TRCF) (EC 3.6.4.-) mfd b1114 JW1100 mfd 129,983 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription-coupled nucleotide-excision repair, DNA damage recognition [GO:0000716] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA translocase activity [GO:0015616]; RNA polymerase core enzyme binding [GO:0043175]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription-coupled nucleotide-excision repair, DNA damage recognition [GO:0000716] ATP binding [GO:0005524]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA translocase activity [GO:0015616]; RNA polymerase core enzyme binding [GO:0043175] GO:0000716; GO:0003677; GO:0003684; GO:0005524; GO:0005829; GO:0006281; GO:0006283; GO:0006355; GO:0006974; GO:0015616; GO:0043175 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00969}. +P22259 PCKA_ECOLI Phosphoenolpyruvate carboxykinase (ATP) (PCK) (PEP carboxykinase) (PEPCK) (EC 4.1.1.49) pckA pck b3403 JW3366 pck pckA 59,643 gluconeogenesis [GO:0006094] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]; phosphoenolpyruvate carboxykinase (ATP) activity [GO:0004612]; gluconeogenesis [GO:0006094] ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]; phosphoenolpyruvate carboxykinase (ATP) activity [GO:0004612] GO:0000287; GO:0004612; GO:0005509; GO:0005524; GO:0005829; GO:0006094 SUBCELLULAR LOCATION: Cytoplasm. +P32676 PTFB3_ECOLI PTS system fructose-like EIIB component 3 (EC 2.7.1.202) (Fructose-like phosphotransferase enzyme IIB component 3) frwD yijN b3953 JW3925 yijN frwD 12,637 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737]; plasma membrane [GO:0005886] cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity [GO:0022877]; protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity [GO:0090582]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity [GO:0022877]; protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity [GO:0090582]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005737; GO:0005886; GO:0009401; GO:0016301; GO:0022877; GO:0090563; GO:0090582 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P69789 PTXB_ECOLI Phosphotransferase enzyme IIB component GlvB (EC 2.7.1.-) (PTS system EIIB component) glvB glvC yidN b3682 JW3659 glvC yidN glvB 17,626 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982] GO:0005886; GO:0008982; GO:0009401; GO:0016021; GO:0016301 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P36979 RLMN_ECOLI Dual-specificity RNA methyltransferase RlmN (EC 2.1.1.192) (23S rRNA (adenine(2503)-C(2))-methyltransferase) (23S rRNA m2A2503 methyltransferase) (Ribosomal RNA large subunit methyltransferase N) (tRNA (adenine(37)-C(2))-methyltransferase) (tRNA m2A37 methyltransferase) rlmN yfgB b2517 JW2501 yfgB rlmN 43,086 response to antibiotic [GO:0046677]; rRNA base methylation [GO:0070475]; tRNA methylation [GO:0030488] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; rRNA (adenine-C2-)-methyltransferase activity [GO:0070040]; rRNA binding [GO:0019843]; tRNA (adenine-C2-)-methyltransferase activity [GO:0002935]; tRNA binding [GO:0000049]; response to antibiotic [GO:0046677]; rRNA base methylation [GO:0070475]; tRNA methylation [GO:0030488] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; rRNA (adenine-C2-)-methyltransferase activity [GO:0070040]; rRNA binding [GO:0019843]; tRNA (adenine-C2-)-methyltransferase activity [GO:0002935]; tRNA binding [GO:0000049] GO:0000049; GO:0002935; GO:0005829; GO:0019843; GO:0030488; GO:0046677; GO:0046872; GO:0051539; GO:0070040; GO:0070475 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A9H1 MUG_ECOLI G/U mismatch-specific DNA glycosylase (EC 3.2.2.28) (Double-strand-specific uracil glycosylase) (Mismatch-specific uracil DNA-glycosylase) (MUG) mug ygjF b3068 JW3040 ygjF mug 18,673 base-excision repair, AP site formation [GO:0006285] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; DNA binding [GO:0003677]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263]; base-excision repair, AP site formation [GO:0006285] DNA binding [GO:0003677]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263] GO:0003677; GO:0005737; GO:0006285; GO:0008263 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P11458 NADA_ECOLI Quinolinate synthase A (EC 2.5.1.72) nadA nicA b0750 JW0733 nicA nadA 38,241 'de novo' NAD biosynthetic process from aspartate [GO:0034628] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; quinolinate synthetase A activity [GO:0008987]; 'de novo' NAD biosynthetic process from aspartate [GO:0034628] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; quinolinate synthetase A activity [GO:0008987] GO:0005829; GO:0008987; GO:0034628; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Cytoplasm. +Q47270 NINE_ECOLI Prophage NinE homolog (Protein NinE homolog from lambdoid prophage DLP12) ninE b0548 JW0536 ninE 6,494 +P0AAK7 NRFC_ECOLI Protein NrfC nrfC yjcJ b4072 JW4033 yjcJ nrfC 24,567 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; nitrite reductase (cytochrome, ammonia-forming) activity [GO:0042279] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; nitrite reductase (cytochrome, ammonia-forming) activity [GO:0042279] GO:0042279; GO:0046872; GO:0051539 +P16256 PANF_ECOLI Sodium/pantothenate symporter (Pantothenate permease) panF b3258 JW3226 panF 51,717 pantothenate transmembrane transport [GO:0015887]; sodium ion export across plasma membrane [GO:0036376] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; pantothenate transmembrane transporter activity [GO:0015233]; sodium ion transmembrane transporter activity [GO:0015081]; symporter activity [GO:0015293]; pantothenate transmembrane transport [GO:0015887]; sodium ion export across plasma membrane [GO:0036376] pantothenate transmembrane transporter activity [GO:0015233]; sodium ion transmembrane transporter activity [GO:0015081]; symporter activity [GO:0015293] GO:0005886; GO:0015081; GO:0015233; GO:0015293; GO:0015887; GO:0016021; GO:0036376 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P75906 PGAB_ECOLI Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase (PGA N-deacetylase) (Poly-beta-1,6-GlcNAc N-deacetylase) (EC 3.5.1.-) pgaB ycdR b1023 JW5142 ycdR pgaB 77,413 carbohydrate metabolic process [GO:0005975]; cell adhesion involved in biofilm formation [GO:0043708]; macromolecule deacylation [GO:0098732] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; carbohydrate metabolic process [GO:0005975]; cell adhesion involved in biofilm formation [GO:0043708]; macromolecule deacylation [GO:0098732] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553] GO:0004553; GO:0005975; GO:0009279; GO:0016810; GO:0043708; GO:0098732 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305|PubMed:18359807}; Lipid-anchor {ECO:0000305|PubMed:18359807}; Periplasmic side {ECO:0000305|PubMed:18359807}. +P0AFC3 NUOA_ECOLI NADH-quinone oxidoreductase subunit A (EC 7.1.1.-) (NADH dehydrogenase I subunit A) (NDH-1 subunit A) (NUO1) nuoA b2288 JW2283 nuoA 16,457 integral component of plasma membrane [GO:0005887]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272] integral component of plasma membrane [GO:0005887]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] GO:0005886; GO:0005887; GO:0008137; GO:0030964; GO:0045272; GO:0048038 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01394, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01394, ECO:0000269|PubMed:15919996}. +P76045 OMPG_ECOLI Outer membrane porin G (Outer membrane protein G) ompG b1319 JW1312 ompG 34,913 carbohydrate transmembrane transport [GO:0034219] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; pore complex [GO:0046930]; maltose transporting porin activity [GO:0015481]; oligosaccharide transporting porin activity [GO:0015478]; porin activity [GO:0015288]; carbohydrate transmembrane transport [GO:0034219] maltose transporting porin activity [GO:0015481]; oligosaccharide transporting porin activity [GO:0015478]; porin activity [GO:0015288] GO:0009279; GO:0015288; GO:0015478; GO:0015481; GO:0034219; GO:0045203; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein. +P0A6G3 PNCC_ECOLI Nicotinamide-nucleotide amidohydrolase PncC (NMN amidohydrolase PncC) (EC 3.5.1.42) (NMN deamidase) (Nicotinamide-nucleotide amidase) pncC ygaD b2700 JW2670 ygaD pncC 17,582 pyridine nucleotide biosynthetic process [GO:0019363] nicotinamide-nucleotide amidase activity [GO:0019159]; pyridine nucleotide biosynthetic process [GO:0019363] nicotinamide-nucleotide amidase activity [GO:0019159] GO:0019159; GO:0019363 +P0C0L7 PROP_ECOLI Proline/betaine transporter (Proline porter II) (PPII) proP b4111 JW4072 proP 54,846 amino acid transport [GO:0006865]; cellular hyperosmotic response [GO:0071474]; cellular hyperosmotic salinity response [GO:0071475]; glycine betaine transport [GO:0031460]; osmosensory signaling pathway [GO:0007231]; proline import across plasma membrane [GO:1905647] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; proline:proton symporter activity [GO:0005297]; amino acid transport [GO:0006865]; cellular hyperosmotic response [GO:0071474]; cellular hyperosmotic salinity response [GO:0071475]; glycine betaine transport [GO:0031460]; osmosensory signaling pathway [GO:0007231]; proline import across plasma membrane [GO:1905647] proline:proton symporter activity [GO:0005297] GO:0005297; GO:0005886; GO:0006865; GO:0007231; GO:0016021; GO:0031460; GO:0071474; GO:0071475; GO:1905647 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:10026245, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P31992 PPTA_ECOLI Tautomerase PptA (EC 5.3.2.-) pptA ydcE b1461 JW1456 ydcE pptA 8,673 cellular aromatic compound metabolic process [GO:0006725] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; intramolecular oxidoreductase activity, interconverting keto- and enol-groups [GO:0016862]; cellular aromatic compound metabolic process [GO:0006725] intramolecular oxidoreductase activity, interconverting keto- and enol-groups [GO:0016862] GO:0005737; GO:0006725; GO:0016862 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A7D7 PUR7_ECOLI Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase) purC b2476 JW2461 purC 26,995 'de novo' IMP biosynthetic process [GO:0006189]; cobalamin biosynthetic process [GO:0009236] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [GO:0004639]; 'de novo' IMP biosynthetic process [GO:0006189]; cobalamin biosynthetic process [GO:0009236] ATP binding [GO:0005524]; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [GO:0004639] GO:0004639; GO:0005524; GO:0005829; GO:0006189; GO:0009236; GO:0016020 +P37758 NARU_ECOLI Nitrate/nitrite transporter NarU (Nitrite extrusion protein 2) (Nitrite facilitator 2) narU yddF b1469 JW1464 yddF narU 49,890 nitrate assimilation [GO:0042128]; nitrate transport [GO:0015706]; nitrite transport [GO:0015707] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; nitrate transmembrane transporter activity [GO:0015112]; nitrite efflux transmembrane transporter activity [GO:0015514]; nitrate assimilation [GO:0042128]; nitrate transport [GO:0015706]; nitrite transport [GO:0015707] nitrate transmembrane transporter activity [GO:0015112]; nitrite efflux transmembrane transporter activity [GO:0015514] GO:0005886; GO:0005887; GO:0015112; GO:0015514; GO:0015706; GO:0015707; GO:0042128 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:18691156}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:18691156}. +P19318 NARY_ECOLI Respiratory nitrate reductase 2 beta chain (EC 1.7.5.1) narY b1467 JW1462 narY 58,558 anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061]; cellular response to DNA damage stimulus [GO:0006974]; nitrate assimilation [GO:0042128] membrane [GO:0016020]; nitrate reductase complex [GO:0009325]; plasma membrane [GO:0005886] membrane [GO:0016020]; nitrate reductase complex [GO:0009325]; plasma membrane [GO:0005886]; 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; nitrate reductase activity [GO:0008940]; anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061]; cellular response to DNA damage stimulus [GO:0006974]; nitrate assimilation [GO:0042128] 3 iron, 4 sulfur cluster binding [GO:0051538]; 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; nitrate reductase activity [GO:0008940] GO:0005886; GO:0006974; GO:0008940; GO:0009055; GO:0009061; GO:0009325; GO:0016020; GO:0019645; GO:0042128; GO:0046872; GO:0051536; GO:0051538; GO:0051539 SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. +P0A9I8 NIRD_ECOLI Nitrite reductase (NADH) small subunit (EC 1.7.1.15) nirD b3366 JW3329 nirD 12,284 anaerobic respiration [GO:0009061]; nitrate assimilation [GO:0042128] cytoplasm [GO:0005737]; nitrite reductase complex [NAD(P)H] [GO:0009344] cytoplasm [GO:0005737]; nitrite reductase complex [NAD(P)H] [GO:0009344]; 2 iron, 2 sulfur cluster binding [GO:0051537]; nitrite reductase [NAD(P)H] activity [GO:0008942]; nitrite reductase NADH activity [GO:0106316]; anaerobic respiration [GO:0009061]; nitrate assimilation [GO:0042128] 2 iron, 2 sulfur cluster binding [GO:0051537]; nitrite reductase [NAD(P)H] activity [GO:0008942]; nitrite reductase NADH activity [GO:0106316] GO:0005737; GO:0008942; GO:0009061; GO:0009344; GO:0042128; GO:0051537; GO:0106316 SUBCELLULAR LOCATION: Cytoplasm. +P06996 OMPC_ECOLI Outer membrane porin C (Outer membrane protein 1B) (Outer membrane protein C) (Porin OmpC) ompC meoA par b2215 JW2203 meoA par ompC 40,368 cellular response to DNA damage stimulus [GO:0006974]; ion transmembrane transport [GO:0034220]; phospholipid transport [GO:0015914]; receptor-mediated virion attachment to host cell [GO:0046813] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; integral component of cell outer membrane [GO:0045203]; pore complex [GO:0046930]; metal ion binding [GO:0046872]; porin activity [GO:0015288]; virus receptor activity [GO:0001618]; cellular response to DNA damage stimulus [GO:0006974]; ion transmembrane transport [GO:0034220]; phospholipid transport [GO:0015914]; receptor-mediated virion attachment to host cell [GO:0046813] metal ion binding [GO:0046872]; porin activity [GO:0015288]; virus receptor activity [GO:0001618] GO:0001618; GO:0006974; GO:0009279; GO:0015288; GO:0015914; GO:0034220; GO:0045203; GO:0046813; GO:0046872; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:2464593}; Multi-pass membrane protein {ECO:0000269|PubMed:16949612}. +P37001 PAGP_ECOLI Lipid A palmitoyltransferase PagP (EC 2.3.1.251) (Lipid A acylation protein) pagP crcA ybeG b0622 JW0617 crcA ybeG pagP 21,770 lipid A biosynthetic process [GO:0009245] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; O-palmitoyltransferase activity [GO:0016416]; lipid A biosynthetic process [GO:0009245] O-palmitoyltransferase activity [GO:0016416] GO:0009245; GO:0009279; GO:0016416 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_00837, ECO:0000269|PubMed:11013210}. +P07001 PNTA_ECOLI NAD(P) transhydrogenase subunit alpha (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase subunit alpha) (Pyridine nucleotide transhydrogenase subunit alpha) pntA b1603 JW1595 pntA 54,623 NADPH regeneration [GO:0006740]; proton transmembrane transport [GO:1902600] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; NAD binding [GO:0051287]; NAD(P)+ transhydrogenase (AB-specific) activity [GO:0008750]; NAD(P)+ transhydrogenase activity [GO:0008746]; NADP binding [GO:0050661]; protein dimerization activity [GO:0046983]; NADPH regeneration [GO:0006740]; proton transmembrane transport [GO:1902600] NAD(P)+ transhydrogenase (AB-specific) activity [GO:0008750]; NAD(P)+ transhydrogenase activity [GO:0008746]; NAD binding [GO:0051287]; NADP binding [GO:0050661]; protein dimerization activity [GO:0046983] GO:0005886; GO:0005887; GO:0006740; GO:0008746; GO:0008750; GO:0046983; GO:0050661; GO:0051287; GO:1902600 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P39199 PRMB_ECOLI 50S ribosomal protein L3 glutamine methyltransferase (L3 MTase) (EC 2.1.1.298) (N5-glutamine methyltransferase PrmB) prmB yfcB b2330 JW5841 yfcB prmB 35,002 peptidyl-glutamine methylation [GO:0018364]; protein methylation [GO:0006479] cytosol [GO:0005829] cytosol [GO:0005829]; nucleic acid binding [GO:0003676]; protein methyltransferase activity [GO:0008276]; protein-glutamine N-methyltransferase activity [GO:0036009]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007]; peptidyl-glutamine methylation [GO:0018364]; protein methylation [GO:0006479] nucleic acid binding [GO:0003676]; protein-glutamine N-methyltransferase activity [GO:0036009]; protein methyltransferase activity [GO:0008276]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007] GO:0003676; GO:0005829; GO:0006479; GO:0008276; GO:0008757; GO:0009007; GO:0018364; GO:0036009 +P05706 PTHA_ECOLI PTS system glucitol/sorbitol-specific EIIA component (EIIA-Gut) (EIII-Gut) (Glucitol/sorbitol-specific phosphotransferase enzyme IIA component) srlB gutB b2704 JW2673 gutB srlB 13,304 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] kinase activity [GO:0016301]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982] GO:0005737; GO:0008982; GO:0009401; GO:0016301; GO:0016773 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:3553176}. +P0AF32 NARV_ECOLI Respiratory nitrate reductase 2 gamma chain (EC 1.7.5.1) narV b1465 JW1460 narV 26,018 anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061]; nitrate assimilation [GO:0042128] integral component of membrane [GO:0016021]; nitrate reductase complex [GO:0009325]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; nitrate reductase complex [GO:0009325]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; nitrate reductase activity [GO:0008940]; anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061]; nitrate assimilation [GO:0042128] electron transfer activity [GO:0009055]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; nitrate reductase activity [GO:0008940] GO:0005886; GO:0008940; GO:0009055; GO:0009061; GO:0009325; GO:0016021; GO:0019645; GO:0020037; GO:0042128; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P37128 NUDK_ECOLI GDP-mannose pyrophosphatase (EC 3.6.1.-) (GDP-mannose hydrolase) (GDPMK) nudK yffH b2467 JW2451 yffH nudK 21,749 nucleoside phosphate metabolic process [GO:0006753]; ribose phosphate metabolic process [GO:0019693] cytosol [GO:0005829] cytosol [GO:0005829]; GDP-mannose hydrolase activity [GO:0052751]; magnesium ion binding [GO:0000287]; nucleoside phosphate metabolic process [GO:0006753]; ribose phosphate metabolic process [GO:0019693] GDP-mannose hydrolase activity [GO:0052751]; magnesium ion binding [GO:0000287] GO:0000287; GO:0005829; GO:0006753; GO:0019693; GO:0052751 +P0AFC7 NUOB_ECOLI NADH-quinone oxidoreductase subunit B (EC 7.1.1.-) (NADH dehydrogenase I subunit B) (NDH-1 subunit B) (NUO2) nuoB b2287 JW5875 nuoB 25,056 aerobic respiration [GO:0009060]; electron transport coupled proton transport [GO:0015990] membrane [GO:0016020]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272] membrane [GO:0016020]; NADH dehydrogenase complex [GO:0030964]; plasma membrane [GO:0005886]; plasma membrane respiratory chain complex I [GO:0045272]; 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038]; aerobic respiration [GO:0009060]; electron transport coupled proton transport [GO:0015990] 4 iron, 4 sulfur cluster binding [GO:0051539]; iron ion binding [GO:0005506]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; quinone binding [GO:0048038] GO:0005506; GO:0005886; GO:0008137; GO:0009060; GO:0015990; GO:0016020; GO:0030964; GO:0045272; GO:0048038; GO:0051539 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. +P23857 PSPE_ECOLI Thiosulfate sulfurtransferase PspE (TST) (EC 2.8.1.1) (Phage shock protein E) pspE b1308 JW1301 pspE 11,475 outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; thiosulfate sulfurtransferase activity [GO:0004792] thiosulfate sulfurtransferase activity [GO:0004792] GO:0004792; GO:0030288; GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:1712397}. +P06959 ODP2_ECOLI Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (E2) aceF b0115 JW0111 aceF 66,096 acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glycolytic process [GO:0006096]; pyruvate metabolic process [GO:0006090] cytoplasm [GO:0005737]; pyruvate dehydrogenase complex [GO:0045254] cytoplasm [GO:0005737]; pyruvate dehydrogenase complex [GO:0045254]; acetyltransferase activity [GO:0016407]; dihydrolipoyllysine-residue acetyltransferase activity [GO:0004742]; lipoic acid binding [GO:0031405]; acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glycolytic process [GO:0006096]; pyruvate metabolic process [GO:0006090] acetyltransferase activity [GO:0016407]; dihydrolipoyllysine-residue acetyltransferase activity [GO:0004742]; lipoic acid binding [GO:0031405] GO:0004742; GO:0005737; GO:0006086; GO:0006090; GO:0006096; GO:0016407; GO:0031405; GO:0045254 +Q46889 OTNK_ECOLI 3-oxo-tetronate kinase (EC 2.7.1.217) (3-dehydrotetronate 4-kinase) otnK ygbK b2737 JW2707 ygbK otnK 41,339 carbohydrate metabolic process [GO:0005975] ATP binding [GO:0005524]; kinase activity [GO:0016301]; carbohydrate metabolic process [GO:0005975] ATP binding [GO:0005524]; kinase activity [GO:0016301] GO:0005524; GO:0005975; GO:0016301 +P0AFI5 PBP7_ECOLI D-alanyl-D-alanine endopeptidase (DD-endopeptidase) (EC 3.4.21.-) (Penicillin-binding protein 7) (PBP-7) pbpG yohB b2134 JW5355 yohB pbpG 33,887 cell wall organization [GO:0071555]; FtsZ-dependent cytokinesis [GO:0043093]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan metabolic process [GO:0000270]; regulation of cell shape [GO:0008360]; response to drug [GO:0042493] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; endopeptidase activity [GO:0004175]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002]; cell wall organization [GO:0071555]; FtsZ-dependent cytokinesis [GO:0043093]; peptidoglycan biosynthetic process [GO:0009252]; peptidoglycan metabolic process [GO:0000270]; regulation of cell shape [GO:0008360]; response to drug [GO:0042493] endopeptidase activity [GO:0004175]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002] GO:0000270; GO:0004175; GO:0008360; GO:0009002; GO:0009252; GO:0042493; GO:0042597; GO:0043093; GO:0071555 SUBCELLULAR LOCATION: Periplasm. +P0A9K3 PHOL_ECOLI PhoH-like protein ybeZ b0660 JW0657 ybeZ 39,039 cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524] ATP binding [GO:0005524] GO:0005524; GO:0005829 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P77366 PGMB_ECOLI Beta-phosphoglucomutase (Beta-PGM) (EC 5.4.2.6) ycjU pgmB b1317 JW1310 pgmB ycjU 23,565 carbohydrate metabolic process [GO:0005975]; cellular response to DNA damage stimulus [GO:0006974]; DNA mediated transformation [GO:0009294]; response to antibiotic [GO:0046677] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; beta-phosphoglucomutase activity [GO:0008801]; hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287]; carbohydrate metabolic process [GO:0005975]; cellular response to DNA damage stimulus [GO:0006974]; DNA mediated transformation [GO:0009294]; response to antibiotic [GO:0046677] beta-phosphoglucomutase activity [GO:0008801]; hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287] GO:0000287; GO:0005737; GO:0005975; GO:0006974; GO:0008801; GO:0009294; GO:0016787; GO:0046677 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:20128927}. +P0AFK2 PNUC_ECOLI Nicotinamide riboside transporter PnuC pnuC b0751 JW0734 pnuC 26,996 nicotinamide riboside transport [GO:0034258] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; nicotinamide riboside transmembrane transporter activity [GO:0034257]; nicotinamide riboside transport [GO:0034258] nicotinamide riboside transmembrane transporter activity [GO:0034257] GO:0005886; GO:0016021; GO:0034257; GO:0034258 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15561822}; Multi-pass membrane protein {ECO:0000305|PubMed:15561822, ECO:0000305|PubMed:15919996}. +P05055 PNP_ECOLI Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (Polynucleotide phosphorylase) (PNPase) pnp b3164 JW5851 pnp 77,101 mRNA catabolic process [GO:0006402]; response to heat [GO:0009408]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; 3'-5'-exoribonuclease activity [GO:0000175]; cyclic-di-GMP binding [GO:0035438]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; polyribonucleotide nucleotidyltransferase activity [GO:0004654]; RNA binding [GO:0003723]; mRNA catabolic process [GO:0006402]; response to heat [GO:0009408]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396] 3'-5'-exoribonuclease activity [GO:0000175]; cyclic-di-GMP binding [GO:0035438]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; polyribonucleotide nucleotidyltransferase activity [GO:0004654]; RNA binding [GO:0003723] GO:0000175; GO:0000287; GO:0003723; GO:0004654; GO:0005829; GO:0006396; GO:0006401; GO:0006402; GO:0009408; GO:0016020; GO:0035438; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01595, ECO:0000269|PubMed:16079137}. Note=Has also been isolated in association with the inner membrane. +P43671 PQIB_ECOLI Intermembrane transport protein PqiB (Paraquat-inducible protein B) pqiB pqi5B b0951 JW0934 pqi5B pqiB 60,520 intermembrane lipid transfer [GO:0120009] integral component of membrane [GO:0016021]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; intermembrane lipid transfer [GO:0120009] identical protein binding [GO:0042802] GO:0005886; GO:0016021; GO:0030288; GO:0042802; GO:0120009 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:27795327}; Single-pass membrane protein {ECO:0000255}; Periplasmic side {ECO:0000269|PubMed:27795327}. +P0A722 LPXA_ECOLI Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (UDP-N-acetylglucosamine acyltransferase) (EC 2.3.1.129) lpxA b0181 JW0176 lpxA 28,080 lipid A biosynthetic process [GO:0009245] cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity [GO:0008780]; identical protein binding [GO:0042802]; lipid A biosynthetic process [GO:0009245] acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity [GO:0008780]; identical protein binding [GO:0042802] GO:0005737; GO:0005829; GO:0008780; GO:0009245; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm. +P0ACD8 MBHL_ECOLI Hydrogenase-1 large chain (HYD1) (EC 1.12.99.6) (Membrane-bound hydrogenase 1 large subunit) (NiFe hydrogenase) hyaB b0973 JW0955 hyaB 66,253 anaerobic respiration [GO:0009061]; fermentation [GO:0006113] [Ni-Fe] hydrogenase complex [GO:0044569]; membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886] [Ni-Fe] hydrogenase complex [GO:0044569]; membrane [GO:0016020]; outer membrane-bounded periplasmic space [GO:0030288]; plasma membrane [GO:0005886]; electron transfer activity [GO:0009055]; ferredoxin hydrogenase activity [GO:0008901]; hydrogenase (acceptor) activity [GO:0033748]; nickel cation binding [GO:0016151]; anaerobic respiration [GO:0009061]; fermentation [GO:0006113] electron transfer activity [GO:0009055]; ferredoxin hydrogenase activity [GO:0008901]; hydrogenase (acceptor) activity [GO:0033748]; nickel cation binding [GO:0016151] GO:0005886; GO:0006113; GO:0008901; GO:0009055; GO:0009061; GO:0016020; GO:0016151; GO:0030288; GO:0033748; GO:0044569 SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. +P0A9F9 METR_ECOLI HTH-type transcriptional regulator MetR metR b3828 JW3804 metR 35,629 methionine biosynthetic process [GO:0009086]; regulation of transcription, DNA-templated [GO:0006355] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; amino acid binding [GO:0016597]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; methionine biosynthetic process [GO:0009086]; regulation of transcription, DNA-templated [GO:0006355] amino acid binding [GO:0016597]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003677; GO:0003700; GO:0005737; GO:0006355; GO:0009086; GO:0016597 SUBCELLULAR LOCATION: Cytoplasm. +P77397 MHPA_ECOLI 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase (3-HCI hydroxylase) (3-HPP hydroxylase) (EC 1.14.13.127) mhpA b0347 JW0338 mhpA 62,186 3-(3-hydroxy)phenylpropionate catabolic process [GO:0019622]; 3-phenylpropionate catabolic process [GO:0019380] 3-(3-hydroxyphenyl)propionate hydroxylase activity [GO:0008688]; FAD binding [GO:0071949]; 3-(3-hydroxy)phenylpropionate catabolic process [GO:0019622]; 3-phenylpropionate catabolic process [GO:0019380] 3-(3-hydroxyphenyl)propionate hydroxylase activity [GO:0008688]; FAD binding [GO:0071949] GO:0008688; GO:0019380; GO:0019622; GO:0071949 +P27245 MARR_ECOLI Multiple antibiotic resistance protein MarR marR cfxB inaR soxQ b1530 JW5248 cfxB inaR soxQ marR 16,065 cellular response to antibiotic [GO:0071236]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; response to heat [GO:0009408] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; cellular response to antibiotic [GO:0071236]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; response to heat [GO:0009408] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003677; GO:0003700; GO:0006355; GO:0009408; GO:0045892; GO:0071236 +P75995 PDEG_ECOLI Probable cyclic di-GMP phosphodiesterase PdeG (EC 3.1.4.52) pdeG ycgG b1168 JW5174 ycgG pdeG 56,906 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cyclic-guanylate-specific phosphodiesterase activity [GO:0071111] cyclic-guanylate-specific phosphodiesterase activity [GO:0071111] GO:0005886; GO:0016021; GO:0071111 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Note=Found associated with the RNA degradosome. {ECO:0000269|PubMed:16139413}. +P75905 PGAC_ECOLI Poly-beta-1,6-N-acetyl-D-glucosamine synthase (PGA synthase) (Poly-beta-1,6-GlcNAc synthase) (EC 2.4.1.-) (Biofilm PGA synthesis protein PgaC) (N-acetylglucosaminyltransferase PgaC) pgaC ycdQ b1022 JW1007 ycdQ pgaC 50,766 cell adhesion involved in biofilm formation [GO:0043708] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; acetylglucosaminyltransferase activity [GO:0008375]; cell adhesion involved in biofilm formation [GO:0043708] acetylglucosaminyltransferase activity [GO:0008375] GO:0005886; GO:0008375; GO:0016021; GO:0043708 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P32672 PTFC2_ECOLI Fructose-like permease IIC component 2 (PTS system fructose-like EIIC component 2) frwC yijJ b3949 JW3921 yijJ frwC 37,086 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; carbohydrate:proton symporter activity [GO:0005351]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401] carbohydrate:proton symporter activity [GO:0005351]; protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [GO:0008982]; protein-phosphocysteine-sugar phosphotransferase activity [GO:0090563] GO:0005351; GO:0005886; GO:0005887; GO:0008982; GO:0009401; GO:0090563 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00427, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00427, ECO:0000269|PubMed:15919996}. +P37177 PT1P_ECOLI Phosphoenolpyruvate-dependent phosphotransferase system (EC 2.7.3.9) (Enzyme I-Ntr) (EINtr) (Phosphotransferase system, enzyme I) ptsP ygdF ygdO b2829 JW2797 ygdF ygdO ptsP 83,716 phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; protein phosphorylation [GO:0006468]; response to organonitrogen compound [GO:0010243] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphoenolpyruvate-protein phosphotransferase activity [GO:0008965]; phosphoenolpyruvate-dependent sugar phosphotransferase system [GO:0009401]; protein phosphorylation [GO:0006468]; response to organonitrogen compound [GO:0010243] kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphoenolpyruvate-protein phosphotransferase activity [GO:0008965] GO:0005737; GO:0006468; GO:0008965; GO:0009401; GO:0010243; GO:0016301; GO:0046872 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0AAH0 PSTB_ECOLI Phosphate import ATP-binding protein PstB (EC 7.3.2.1) (ABC phosphate transporter) (Phosphate-transporting ATPase) pstB phoT b3725 JW3703 phoT pstB 29,027 phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; regulation of phosphatase activity [GO:0010921] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase-coupled phosphate ion transmembrane transporter activity [GO:0015415]; inorganic phosphate transmembrane transporter activity [GO:0005315]; phosphate ion transmembrane transport [GO:0035435]; phosphate ion transport [GO:0006817]; regulation of phosphatase activity [GO:0010921] ATPase-coupled phosphate ion transmembrane transporter activity [GO:0015415]; ATP binding [GO:0005524]; inorganic phosphate transmembrane transporter activity [GO:0005315] GO:0005315; GO:0005524; GO:0005886; GO:0006817; GO:0010921; GO:0015415; GO:0035435 SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. +P31550 THIB_ECOLI Thiamine-binding periplasmic protein thiB tbpA yabL b0068 JW0067 tbpA yabL thiB 36,163 thiamine transport [GO:0015888]; transmembrane transport [GO:0055085] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; thiamine binding [GO:0030975]; thiamine pyrophosphate binding [GO:0030976]; thiamine transport [GO:0015888]; transmembrane transport [GO:0055085] thiamine binding [GO:0030975]; thiamine pyrophosphate binding [GO:0030976] GO:0015888; GO:0030288; GO:0030975; GO:0030976; GO:0055085 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:12182833}. +P52097 TILS_ECOLI tRNA(Ile)-lysidine synthase (EC 6.3.4.19) (tRNA(Ile)-2-lysyl-cytidine synthase) (tRNA(Ile)-lysidine synthetase) tilS mesJ yaeN b0188 JW0183 mesJ yaeN tilS 48,204 tRNA modification [GO:0006400]; tRNA wobble base lysidine biosynthesis [GO:0002136] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; tRNA(Ile)-lysidine synthase activity [GO:0032267]; tRNA modification [GO:0006400]; tRNA wobble base lysidine biosynthesis [GO:0002136] ATP binding [GO:0005524]; identical protein binding [GO:0042802]; tRNA(Ile)-lysidine synthase activity [GO:0032267] GO:0002136; GO:0005524; GO:0005829; GO:0006400; GO:0032267; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P00934 THRC_ECOLI Threonine synthase (TS) (EC 4.2.3.1) thrC b0004 JW0003 thrC 47,114 threonine biosynthetic process [GO:0009088] cytosol [GO:0005829] cytosol [GO:0005829]; pyridoxal phosphate binding [GO:0030170]; threonine synthase activity [GO:0004795]; threonine biosynthetic process [GO:0009088] pyridoxal phosphate binding [GO:0030170]; threonine synthase activity [GO:0004795] GO:0004795; GO:0005829; GO:0009088; GO:0030170 +P14294 TOP3_ECOLI DNA topoisomerase 3 (EC 5.6.2.1) (DNA topoisomerase III) topB b1763 JW1752 topB 73,217 chromosome separation [GO:0051304]; DNA-dependent DNA replication [GO:0006261]; DNA recombination [GO:0006310]; DNA topological change [GO:0006265] cytoplasmic replication fork [GO:0043597] cytoplasmic replication fork [GO:0043597]; DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; magnesium ion binding [GO:0000287]; sequence-specific single stranded DNA binding [GO:0098847]; chromosome separation [GO:0051304]; DNA recombination [GO:0006310]; DNA topological change [GO:0006265]; DNA-dependent DNA replication [GO:0006261] DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO:0003917]; magnesium ion binding [GO:0000287]; sequence-specific single stranded DNA binding [GO:0098847] GO:0000287; GO:0003917; GO:0006261; GO:0006265; GO:0006310; GO:0043597; GO:0051304; GO:0098847 +P76256 TSAB_ECOLI tRNA threonylcarbamoyladenosine biosynthesis protein TsaB (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaB) tsaB yeaZ b1807 JW1796 yeaZ tsaB 25,181 tRNA threonylcarbamoyladenosine modification [GO:0002949] cytosol [GO:0005829] cytosol [GO:0005829]; identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237]; tRNA threonylcarbamoyladenosine modification [GO:0002949] identical protein binding [GO:0042802]; metallopeptidase activity [GO:0008237] GO:0002949; GO:0005829; GO:0008237; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19376873}. +P0AGJ7 TRML_ECOLI tRNA (cytidine(34)-2'-O)-methyltransferase (EC 2.1.1.207) (tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL) trmL yibK b3606 JW3581 yibK trmL 17,726 wobble position cytosine ribose methylation [GO:0002131]; wobble position uridine ribose methylation [GO:0002132] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; RNA binding [GO:0003723]; tRNA (cytosine-2'-O-)-methyltransferase activity [GO:0052666]; tRNA (uracil-2'-O-)-methyltransferase activity [GO:0052665]; wobble position cytosine ribose methylation [GO:0002131]; wobble position uridine ribose methylation [GO:0002132] RNA binding [GO:0003723]; tRNA (cytosine-2'-O-)-methyltransferase activity [GO:0052666]; tRNA (uracil-2'-O-)-methyltransferase activity [GO:0052665] GO:0002131; GO:0002132; GO:0003723; GO:0005737; GO:0052665; GO:0052666 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01885}. +P52696 YBHD_ECOLI Uncharacterized HTH-type transcriptional regulator YbhD ybhD b0768 JW5896 ybhD 36,058 regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700] GO:0000986; GO:0003700; GO:0005829; GO:0006355 +P75764 YBHJ_ECOLI Uncharacterized protein YbhJ ybhJ b0771 JW5103 ybhJ 81,505 response to oxidative stress [GO:0006979]; tricarboxylic acid cycle [GO:0006099] cytosol [GO:0005829] cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; metal ion binding [GO:0046872]; response to oxidative stress [GO:0006979]; tricarboxylic acid cycle [GO:0006099] 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; metal ion binding [GO:0046872] GO:0003994; GO:0005829; GO:0006099; GO:0006979; GO:0046872; GO:0051539 +P77221 YAHG_ECOLI Uncharacterized protein YahG yahG b0321 JW0313 yahG 50,374 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P71297 YAGN_ECOLI Uncharacterized protein YagN yagN b0280 JW0274 yagN 15,815 +P0AB12 YCCF_ECOLI Inner membrane protein YccF yccF b0961 JW0944 yccF 16,275 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P52636 YCCM_ECOLI Putative electron transport protein YccM yccM b0992 JW0977 yccM 40,097 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0005886; GO:0016021; GO:0046872; GO:0051539 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77504 YBBP_ECOLI Uncharacterized ABC transporter permease YbbP ybbP b0496 JW0485 ybbP 89,332 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P75737 YBFP_ECOLI Uncharacterized lipoprotein YbfP ybfP b0689 JW0676 ybfP 18,282 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P76162 YDFU_ECOLI Uncharacterized protein YdfU ydfU b1560 JW5909 ydfU 39,260 +Q46824 YGFX_ECOLI Inner membrane protein YgfX (Toxin CptA) ygfX cptA b2896 JW2864 cptA ygfX 16,064 negative regulation of protein binding [GO:0032091]; regulation of cell shape [GO:0008360] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; negative regulation of protein binding [GO:0032091]; regulation of cell shape [GO:0008360] GO:0005887; GO:0008360; GO:0032091 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:22239607}; Multi-pass membrane protein {ECO:0000269|PubMed:22239607}. +P76512 YFDP_ECOLI Uncharacterized protein YfdP yfdP b2359 JW2356 yfdP 13,102 +P45421 YHCE_ECOLI Putative uncharacterized protein YhcE yhcE b4569 b3217 yhcE 19,193 +P45767 YHDX_ECOLI Putative amino-acid ABC transporter permease protein YhdX yhdX b3269 JW5544 yhdX 43,261 amino acid transport [GO:0006865] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; amino acid transport [GO:0006865] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0006865; GO:0022857; GO:0043190 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. +P52133 YFJR_ECOLI Uncharacterized HTH-type transcriptional regulator YfjR yfjR b2634 JW2615 yfjR 26,606 regulation of single-species biofilm formation [GO:1900190] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; regulation of single-species biofilm formation [GO:1900190] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:1900190 +P76389 YEGH_ECOLI UPF0053 protein YegH yegH b2063 JW5336 yegH 59,450 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; flavin adenine dinucleotide binding [GO:0050660] flavin adenine dinucleotide binding [GO:0050660] GO:0005886; GO:0016021; GO:0050660 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0A8C4 YGFB_ECOLI UPF0149 protein YgfB ygfB b2909 JW5473 ygfB 21,230 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P75977 YMFM_ECOLI Uncharacterized protein YmfM ymfM b1148 JW1134 ymfM 12,156 +P76043 YCJQ_ECOLI D-guloside 3-dehydrogenase (EC 1.1.1.-) ycjQ b1313 JW1306 ycjQ 38,217 carbohydrate metabolic process [GO:0005975] oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; zinc ion binding [GO:0008270]; carbohydrate metabolic process [GO:0005975] oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; zinc ion binding [GO:0008270] GO:0005975; GO:0008270; GO:0016616 +Q46797 YGEQ_ECOLI Uncharacterized lipoprotein YgeQ ygeQ b2863 JW5461 ygeQ 29,513 carbohydrate metabolic process [GO:0005975] plasma membrane [GO:0005886] plasma membrane [GO:0005886]; carbohydrate metabolic process [GO:0005975] GO:0005886; GO:0005975 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000305}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P0ACY9 YEBG_ECOLI Uncharacterized protein YebG yebG b1848 JW1837 yebG 10,717 DNA repair [GO:0006281]; response to X-ray [GO:0010165]; SOS response [GO:0009432] cytosol [GO:0005829] cytosol [GO:0005829]; DNA repair [GO:0006281]; response to X-ray [GO:0010165]; SOS response [GO:0009432] GO:0005829; GO:0006281; GO:0009432; GO:0010165 +P67624 YHEU_ECOLI UPF0270 protein YheU yheU b3354 JW3317 yheU 8,470 +P45804 YHGE_ECOLI Uncharacterized protein YhgE yhgE b3402 JW3365 yhgE 64,637 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P39382 YJIK_ECOLI Uncharacterized protein YjiK yjiK b4333 JW5869 yjiK 31,956 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Single-pass membrane protein {ECO:0000305}. +P27375 YJAZ_ECOLI Protein YjaZ (Heat shock protein C) yjaZ htrC b3989 JW3952 htrC yjaZ 21,131 +P0AF80 YJFL_ECOLI UPF0719 inner membrane protein YjfL yjfL b4184 JW4142 yjfL 14,224 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P37631 YHIN_ECOLI Uncharacterized protein YhiN yhiN b3492 JW3459 yhiN 43,741 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P76010 YCGR_ECOLI Flagellar brake protein YcgR (Cyclic di-GMP binding protein YcgR) ycgR b1194 JW1183 ycgR 27,857 bacterial-type flagellum-dependent cell motility [GO:0071973]; regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed [GO:0071945] bacterial-type flagellum basal body [GO:0009425] bacterial-type flagellum basal body [GO:0009425]; cyclic-di-GMP binding [GO:0035438]; bacterial-type flagellum-dependent cell motility [GO:0071973]; regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed [GO:0071945] cyclic-di-GMP binding [GO:0035438] GO:0009425; GO:0035438; GO:0071945; GO:0071973 SUBCELLULAR LOCATION: Bacterial flagellum basal body {ECO:0000269|PubMed:20303158}. +P76584 YPHB_ECOLI Uncharacterized protein YphB yphB b2544 JW2528 yphB 32,716 cellular response to DNA damage stimulus [GO:0006974]; galactose catabolic process via UDP-galactose [GO:0033499]; glucose metabolic process [GO:0006006] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; aldose 1-epimerase activity [GO:0004034]; carbohydrate binding [GO:0030246]; cellular response to DNA damage stimulus [GO:0006974]; galactose catabolic process via UDP-galactose [GO:0033499]; glucose metabolic process [GO:0006006] aldose 1-epimerase activity [GO:0004034]; carbohydrate binding [GO:0030246] GO:0004034; GO:0005737; GO:0006006; GO:0006974; GO:0030246; GO:0033499 +P46857 YRHB_ECOLI Uncharacterized protein YrhB yrhB b3446 JW3411 yrhB 10,613 +P76073 YNAE_ECOLI Uncharacterized protein YnaE ynaE b1375 JW1369 ynaE 8,751 response to cold [GO:0009409] response to cold [GO:0009409] GO:0009409 +P0AE39 YPDB_ECOLI Transcriptional regulatory protein YpdB ypdB b2381 JW2378 ypdB 28,721 regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829]; protein-DNA complex [GO:0032993] cytosol [GO:0005829]; protein-DNA complex [GO:0032993]; DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription activator activity [GO:0001216]; phosphorelay response regulator activity [GO:0000156]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000156; GO:0000976; GO:0001216; GO:0003677; GO:0005829; GO:0006355; GO:0032993 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P77699 TFAD_ECOLI Protein TfaD (Tail fiber assembly protein homolog from lambdoid prophage DLP12) tfaD ybcX b0561 ybcX tfaD 21,203 +P0AFZ7 TRKH_ECOLI Trk system potassium uptake protein TrkH trkH b3849 JW5576 trkH 52,960 potassium ion transmembrane transport [GO:0071805] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; potassium channel activity [GO:0005267]; potassium ion binding [GO:0030955]; potassium ion transmembrane transporter activity [GO:0015079]; potassium:chloride symporter activity [GO:0015379]; potassium ion transmembrane transport [GO:0071805] potassium:chloride symporter activity [GO:0015379]; potassium channel activity [GO:0005267]; potassium ion binding [GO:0030955]; potassium ion transmembrane transporter activity [GO:0015079] GO:0005267; GO:0005887; GO:0015079; GO:0015379; GO:0030955; GO:0071805 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996}. +P0AAD4 TYRP_ECOLI Tyrosine-specific transport protein (Tyrosine permease) tyrP b1907 JW1895 tyrP 42,819 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; aromatic amino acid transmembrane transporter activity [GO:0015173] aromatic amino acid transmembrane transporter activity [GO:0015173] GO:0005886; GO:0005887; GO:0015173 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P09835 UHPB_ECOLI Signal transduction histidine-protein kinase/phosphatase UhpB (EC 2.7.13.3) (EC 3.1.3.-) uhpB b3668 JW3643 uhpB 56,306 protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155]; protein dimerization activity [GO:0046983]; protein autophosphorylation [GO:0046777]; signal transduction [GO:0007165] ATP binding [GO:0005524]; phosphoprotein phosphatase activity [GO:0004721]; phosphorelay sensor kinase activity [GO:0000155]; protein dimerization activity [GO:0046983] GO:0000155; GO:0004721; GO:0005524; GO:0005886; GO:0007165; GO:0016021; GO:0046777; GO:0046983 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P0A698 UVRA_ECOLI UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A) uvrA dinE b4058 JW4019 dinE uvrA 103,868 DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; response to radiation [GO:0009314]; SOS response [GO:0009432] cytosol [GO:0005829]; excinuclease repair complex [GO:0009380] cytosol [GO:0005829]; excinuclease repair complex [GO:0009380]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; DNA binding [GO:0003677]; excinuclease ABC activity [GO:0009381]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; response to radiation [GO:0009314]; SOS response [GO:0009432] ATPase activity [GO:0016887]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; excinuclease ABC activity [GO:0009381]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270] GO:0003677; GO:0005524; GO:0005829; GO:0006281; GO:0006289; GO:0008270; GO:0009314; GO:0009380; GO:0009381; GO:0009432; GO:0016887; GO:0042626; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}. +P77726 YAJR_ECOLI Inner membrane transport protein YajR yajR b0427 JW5059 yajR 48,810 transmembrane transport [GO:0055085] integral component of plasma membrane [GO:0005887] integral component of plasma membrane [GO:0005887]; transmembrane transporter activity [GO:0022857]; transmembrane transport [GO:0055085] transmembrane transporter activity [GO:0022857] GO:0005887; GO:0022857; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P75750 YBGQ_ECOLI Uncharacterized outer membrane usher protein YbgQ ybgQ b0718 JW5099 ybgQ 90,128 pilus assembly [GO:0009297] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; fimbrial usher porin activity [GO:0015473]; pilus assembly [GO:0009297] fimbrial usher porin activity [GO:0015473] GO:0009279; GO:0009297; GO:0015473; GO:0016021 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. +P75874 YCCU_ECOLI Uncharacterized protein YccU yccU b0965 JW5130 yccU 14,701 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P77199 YAIT_ECOLI Putative uncharacterized protein YaiT yaiT b4580 JW0362/JW5051 b0371 b0374 yaiT 104,725 outer membrane [GO:0019867] outer membrane [GO:0019867] GO:0019867 +P0DPM5 YABR_ECOLI Protein YabR yabR b4726 yabR 1,758 +Q46819 YGFS_ECOLI Putative electron transport protein YgfS ygfS b2886 JW5468 ygfS 17,513 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0046872; GO:0051539 +P45472 YHBQ_ECOLI UPF0213 protein YhbQ yhbQ b3155 JW3124 yhbQ 11,270 nucleic acid phosphodiester bond hydrolysis [GO:0090305] 3'-5'-exodeoxyribonuclease activity [GO:0008296]; endodeoxyribonuclease activity [GO:0004520]; nucleic acid phosphodiester bond hydrolysis [GO:0090305] 3'-5'-exodeoxyribonuclease activity [GO:0008296]; endodeoxyribonuclease activity [GO:0004520] GO:0004520; GO:0008296; GO:0090305 +P76192 YDHV_ECOLI Uncharacterized oxidoreductase YdhV (EC 1.-.-.-) ydhV b1673 JW5272 ydhV 77,877 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; molybdopterin cofactor binding [GO:0043546]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [GO:0016625] 4 iron, 4 sulfur cluster binding [GO:0051539]; electron transfer activity [GO:0009055]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; molybdopterin cofactor binding [GO:0043546]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [GO:0016625] GO:0009055; GO:0016625; GO:0043546; GO:0046872; GO:0051536; GO:0051539 +P77748 YDIJ_ECOLI Uncharacterized protein YdiJ ydiJ b1687 JW1677 ydiJ 113,248 lactate catabolic process [GO:1903457] 4 iron, 4 sulfur cluster binding [GO:0051539]; D-lactate dehydrogenase (cytochrome) activity [GO:0004458]; D-lactate dehydrogenase activity [GO:0008720]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; lactate catabolic process [GO:1903457] 4 iron, 4 sulfur cluster binding [GO:0051539]; D-lactate dehydrogenase (cytochrome) activity [GO:0004458]; D-lactate dehydrogenase activity [GO:0008720]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872] GO:0004458; GO:0008720; GO:0046872; GO:0050660; GO:0051539; GO:0071949; GO:1903457 +P33349 YEHM_ECOLI Uncharacterized protein YehM yehM yehN yehO b2120 JW2108 yehN yehO yehM 83,390 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P11865 YHAB_ECOLI Uncharacterized protein YhaB yhaB b3120 JW3091 yhaB 20,577 +P42592 YGJK_ECOLI Glucosidase YgjK (EC 3.2.1.-) ygjK b3080 JW3051 ygjK 88,321 cellular response to DNA damage stimulus [GO:0006974]; trehalose metabolic process [GO:0005991] alpha,alpha-trehalase activity [GO:0004555]; glucosidase activity [GO:0015926]; metal ion binding [GO:0046872]; cellular response to DNA damage stimulus [GO:0006974]; trehalose metabolic process [GO:0005991] alpha,alpha-trehalase activity [GO:0004555]; glucosidase activity [GO:0015926]; metal ion binding [GO:0046872] GO:0004555; GO:0005991; GO:0006974; GO:0015926; GO:0046872 +P0A8L7 YCIU_ECOLI UPF0263 protein YciU yciU b1248 JW1240 yciU 12,687 +P56614 YMDF_ECOLI Uncharacterized protein YmdF ymdF b4518 JW5136 ymdF 5,883 +P0AFU0 YEJB_ECOLI Inner membrane ABC transporter permease protein YejB yejB b2178 JW2166 yejB 40,360 microcin transport [GO:0042884]; oligopeptide transmembrane transport [GO:0035672] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; microcin transport [GO:0042884]; oligopeptide transmembrane transport [GO:0035672] GO:0005886; GO:0016021; GO:0035672; GO:0042884 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +Q46787 YGEG_ECOLI Uncharacterized protein YgeG ygeG b2851 JW2819 ygeG 19,093 +P75994 YMGC_ECOLI Uncharacterized protein YmgC ymgC b1167 JW1154 ymgC 9,701 +P33014 YEED_ECOLI Putative sulfur carrier protein YeeD yeeD b2012 JW1994 yeeD 8,148 +P76004 YCGM_ECOLI Uncharacterized protein YcgM ycgM b1180 JW1169 ycgM 23,711 acetylpyruvate hydrolase activity [GO:0018773]; metal ion binding [GO:0046872] acetylpyruvate hydrolase activity [GO:0018773]; metal ion binding [GO:0046872] GO:0018773; GO:0046872 +Q46831 YQGA_ECOLI Uncharacterized protein YqgA yqgA b2966 JW2934 yqgA 24,614 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +Q46858 YQHG_ECOLI Uncharacterized protein YqhG yqhG yqhF b3013 JW5500 yqhF yqhG 34,983 +P0DPP5 YQFI_ECOLI Protein YqfI yqfI b4754 yqfI 3,191 +P46879 YQGD_ECOLI Protein YqgD yqgD b2941 JW2908 yqgD 9,519 +P0DPP6 YQHI_ECOLI Protein YqhI yqhI b4755 yqhI 5,465 +P0DSG4 YQHJ_ECOLI Protein YqhJ yqhJ b4786 yqhJ 2,198 +P64567 YQGB_ECOLI Uncharacterized protein YqgB yqgB b2939 JW2906 yqgB 4,859 response to acidic pH [GO:0010447] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; response to acidic pH [GO:0010447] GO:0005737; GO:0010447 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19121005}. +P64596 YRAP_ECOLI Uncharacterized protein YraP yraP b3150 JW3119 yraP 20,028 response to osmotic stress [GO:0006970] cell division site [GO:0032153]; cell outer membrane [GO:0009279]; outer membrane-bounded periplasmic space [GO:0030288] cell division site [GO:0032153]; cell outer membrane [GO:0009279]; outer membrane-bounded periplasmic space [GO:0030288]; response to osmotic stress [GO:0006970] GO:0006970; GO:0009279; GO:0030288; GO:0032153 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P45795 YRDB_ECOLI Uncharacterized protein YrdB yrdB b3280 JW3241 yrdB 10,007 +P64636 YRFG_ECOLI GMP/IMP nucleotidase YrfG (EC 3.1.3.5) yrfG b3399 JW5865 yrfG 25,399 dephosphorylation [GO:0016311]; DNA repair [GO:0006281] cytosol [GO:0005829] cytosol [GO:0005829]; GMP 5'-nucleotidase activity [GO:0050484]; IMP 5'-nucleotidase activity [GO:0050483]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; phosphoglycolate phosphatase activity [GO:0008967]; purine nucleosidase activity [GO:0008477]; dephosphorylation [GO:0016311]; DNA repair [GO:0006281] GMP 5'-nucleotidase activity [GO:0050484]; IMP 5'-nucleotidase activity [GO:0050483]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; phosphoglycolate phosphatase activity [GO:0008967]; purine nucleosidase activity [GO:0008477] GO:0000287; GO:0005829; GO:0006281; GO:0008477; GO:0008967; GO:0016311; GO:0030145; GO:0050483; GO:0050484 +P58095 YPJI_ECOLI Putative UPF0401 protein YpjI ypjI b4644 JW2623.1 b2641.1 ypjI 10,073 +P65367 YQCA_ECOLI Flavodoxin YqcA yqcA b2790 JW2761 yqcA 16,274 FMN binding [GO:0010181] FMN binding [GO:0010181] GO:0010181 +P76280 YOBB_ECOLI Uncharacterized protein YobB yobB b1843 JW1832 yobB 24,395 nitrogen compound metabolic process [GO:0006807] nitrogen compound metabolic process [GO:0006807] GO:0006807 +P76222 YNJA_ECOLI Uncharacterized protein YnjA ynjA b1753 JW1742 ynjA 20,533 peroxiredoxin activity [GO:0051920] peroxiredoxin activity [GO:0051920] GO:0051920 +C1P610 YPDK_ECOLI Uncharacterized membrane protein YpdK ypdK b4680 JW2375.1 ypdK 2,704 integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] GO:0005886; GO:0016020; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:19121005, ECO:0000305|PubMed:21778229}; Single-pass membrane protein {ECO:0000269|PubMed:19121005, ECO:0000269|PubMed:21778229}. +P42620 YQJG_ECOLI Glutathionyl-hydroquinone reductase YqjG (GS-HQR) (EC 1.8.5.7) yqjG b3102 JW3073 yqjG 37,386 glutathione metabolic process [GO:0006749] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; glutathione transferase activity [GO:0004364]; oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor [GO:0016672]; glutathione metabolic process [GO:0006749] glutathione transferase activity [GO:0004364]; oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor [GO:0016672] GO:0004364; GO:0005737; GO:0006749; GO:0016672 +P77559 YNFL_ECOLI Uncharacterized HTH-type transcriptional regulator YnfL ynfL b1595 JW1587 ynfL 33,281 regulation of transcription, DNA-templated [GO:0006355] protein-DNA complex [GO:0032993] protein-DNA complex [GO:0032993]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700] GO:0000986; GO:0003700; GO:0006355; GO:0032993 +P64581 YQJD_ECOLI Uncharacterized protein YqjD yqjD b3098 JW3069 yqjD 11,051 cell pole [GO:0060187]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] cell pole [GO:0060187]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022] ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022] GO:0005886; GO:0016021; GO:0043022; GO:0043024; GO:0060187 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:22380631, ECO:0000269|PubMed:22661687}; Single-pass membrane protein {ECO:0000269|PubMed:22380631, ECO:0000269|PubMed:22661687}. Note=Predominantly localized to 1 cell pole in stationary phase, with a few smaller foci elsewhere in the cell; polar localization depends on the minCDE operon. +P77718 THII_ECOLI tRNA sulfurtransferase (EC 2.8.1.4) (Sulfur carrier protein ThiS sulfurtransferase) (Thiamine biosynthesis protein ThiI) (tRNA 4-thiouridine synthase) thiI yajK b0423 JW0413 yajK thiI 54,973 thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229]; thiazole biosynthetic process [GO:0052837]; tRNA 4-thiouridine biosynthesis [GO:0002937] cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; sulfurtransferase activity [GO:0016783]; tRNA adenylyltransferase activity [GO:0004810]; tRNA binding [GO:0000049]; thiamine biosynthetic process [GO:0009228]; thiamine diphosphate biosynthetic process [GO:0009229]; thiazole biosynthetic process [GO:0052837]; tRNA 4-thiouridine biosynthesis [GO:0002937] ATP binding [GO:0005524]; sulfurtransferase activity [GO:0016783]; tRNA adenylyltransferase activity [GO:0004810]; tRNA binding [GO:0000049] GO:0000049; GO:0002937; GO:0004810; GO:0005524; GO:0005829; GO:0009228; GO:0009229; GO:0016783; GO:0052837 SUBCELLULAR LOCATION: Cytoplasm. +P42632 TDCE_ECOLI PFL-like enzyme TdcE (Keto-acid formate acetyltransferase) (Keto-acid formate-lyase) (Ketobutyrate formate-lyase) (KFL) (EC 2.3.1.-) (Pyruvate formate-lyase) (PFL) (EC 2.3.1.54) tdcE yhaS b3114 JW5522 yhaS tdcE 85,936 carbohydrate metabolic process [GO:0005975]; L-threonine catabolic process to propionate [GO:0070689]; threonine catabolic process [GO:0006567] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020] cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; 2-ketobutyrate formate-lyase activity [GO:0043875]; formate C-acetyltransferase activity [GO:0008861]; carbohydrate metabolic process [GO:0005975]; L-threonine catabolic process to propionate [GO:0070689]; threonine catabolic process [GO:0006567] 2-ketobutyrate formate-lyase activity [GO:0043875]; formate C-acetyltransferase activity [GO:0008861] GO:0005737; GO:0005829; GO:0005975; GO:0006567; GO:0008861; GO:0016020; GO:0043875; GO:0070689 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. +P0AGG8 TLDD_ECOLI Metalloprotease TldD (EC 3.4.-.-) tldD yhdO b3244 JW3213 yhdO tldD 51,364 proteolysis [GO:0006508] cytosol [GO:0005829] cytosol [GO:0005829]; metallopeptidase activity [GO:0008237]; proteolysis [GO:0006508] metallopeptidase activity [GO:0008237] GO:0005829; GO:0006508; GO:0008237 +P37903 USPF_ECOLI Universal stress protein F uspF ynaF yzzL b1376 JW1370 ynaF yzzL uspF 16,017 cell adhesion [GO:0007155]; response to oxidative stress [GO:0006979] ATP binding [GO:0005524]; cell adhesion [GO:0007155]; response to oxidative stress [GO:0006979] ATP binding [GO:0005524] GO:0005524; GO:0006979; GO:0007155 +Q46814 XDHD_ECOLI Probable hypoxanthine oxidase XdhD (EC 1.-.-.-) xdhD ygfN b2881 JW2849 ygfN xdhD 103,519 purine nucleobase metabolic process [GO:0006144]; purine ribonucleoside salvage [GO:0006166] 2 iron, 2 sulfur cluster binding [GO:0051537]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491]; purine nucleobase metabolic process [GO:0006144]; purine ribonucleoside salvage [GO:0006166] 2 iron, 2 sulfur cluster binding [GO:0051537]; iron ion binding [GO:0005506]; oxidoreductase activity [GO:0016491] GO:0005506; GO:0006144; GO:0006166; GO:0016491; GO:0051537 +P27832 WECD_ECOLI dTDP-fucosamine acetyltransferase (EC 2.3.1.210) (TDP-fucosamine acetyltransferase) (dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase) wecD rffC yifH b3790 JW5597 rffC yifH wecD 24,220 enterobacterial common antigen biosynthetic process [GO:0009246] N-acetyltransferase activity [GO:0008080]; enterobacterial common antigen biosynthetic process [GO:0009246] N-acetyltransferase activity [GO:0008080] GO:0008080; GO:0009246 +P27828 WECB_ECOLI UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) (Bacteriophage N4 adsorption protein C) (UDP-GlcNAc-2-epimerase) wecB nfrC rffE yifF b3786 JW5600 nfrC rffE yifF wecB 42,245 enterobacterial common antigen biosynthetic process [GO:0009246] cytosol [GO:0005829] cytosol [GO:0005829]; identical protein binding [GO:0042802]; UDP-N-acetylglucosamine 2-epimerase activity [GO:0008761]; enterobacterial common antigen biosynthetic process [GO:0009246] identical protein binding [GO:0042802]; UDP-N-acetylglucosamine 2-epimerase activity [GO:0008761] GO:0005829; GO:0008761; GO:0009246; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02028, ECO:0000269|PubMed:8226648}. +Q47684 YAFW_ECOLI Antitoxin YafW yafW b0246 JW0235 yafW 11,940 positive regulation of cytoskeleton organization [GO:0051495] positive regulation of cytoskeleton organization [GO:0051495] GO:0051495 +P71296 YAGM_ECOLI Uncharacterized protein YagM yagM b0279 JW0273 yagM 32,679 +P77297 YAHE_ECOLI Uncharacterized protein YahE yahE b0319 JW0311 yahE 32,266 +P0A8X4 YCCT_ECOLI UPF0319 protein YccT yccT b0964 JW0947 yccT 24,594 +P75839 YCAP_ECOLI UPF0702 transmembrane protein YcaP ycaP b0906 JW0889 ycaP 26,282 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0AFP0 YADS_ECOLI UPF0126 inner membrane protein YadS yadS b0157 JW0153 yadS 22,128 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P64557 YGFM_ECOLI Uncharacterized protein YgfM ygfM b2880 JW2848 ygfM 28,650 FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491] FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491] GO:0016491; GO:0071949 +P0ADS9 YGGN_ECOLI Uncharacterized protein YggN yggN b2958 JW2925 yggN 26,429 +P31443 YIDF_ECOLI Uncharacterized protein YidF yidF b3674 JW3650 yidF 19,188 oxidoreductase activity [GO:0016491] oxidoreductase activity [GO:0016491] GO:0016491 +P77552 YDHQ_ECOLI Uncharacterized protein YdhQ ydhQ b1664 JW1656 ydhQ 42,876 cellular response to DNA damage stimulus [GO:0006974] cellular response to DNA damage stimulus [GO:0006974] GO:0006974 +P76402 YEGP_ECOLI UPF0339 protein YegP yegP b2080 JW5339 yegP 12,024 double-strand break repair [GO:0006302] double-strand break repair [GO:0006302] GO:0006302 +P77337 YDIS_ECOLI Probable electron transfer flavoprotein-quinone oxidoreductase YdiS (EC 1.5.5.-) ydiS b1699 JW1689 ydiS 45,923 FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491] FAD binding [GO:0071949]; oxidoreductase activity [GO:0016491] GO:0016491; GO:0071949 +P0ACR4 YEIE_ECOLI Uncharacterized HTH-type transcriptional regulator YeiE yeiE b2157 JW2144 yeiE 32,724 regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351] DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003700; GO:0006351; GO:0006355 +P0A8Y5 YIDA_ECOLI Sugar phosphatase YidA (EC 3.1.3.23) yidA b3697 JW3674 yidA 29,721 cytosol [GO:0005829] cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; sugar-phosphatase activity [GO:0050308] magnesium ion binding [GO:0000287]; phosphatase activity [GO:0016791]; sugar-phosphatase activity [GO:0050308] GO:0000287; GO:0005829; GO:0016791; GO:0050308 +P37662 YHJX_ECOLI Uncharacterized MFS-type transporter YhjX yhjX b3547 JW3516 yhjX 42,951 cellular response to nutrient levels [GO:0031669] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; cellular response to nutrient levels [GO:0031669] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857; GO:0031669 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:23222720}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:23222720}. +P37626 YHII_ECOLI Uncharacterized protein YhiI yhiI b3487 JW3454 yhiI 38,828 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 +P39390 YJIS_ECOLI Uncharacterized protein YjiS yjiS b4341 JW4304 yjiS 6,709 +P37621 YHHS_ECOLI Uncharacterized MFS-type transporter YhhS yhhS b3473 JW5945 yhhS 42,156 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01118, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01118, ECO:0000305|PubMed:15919996}. +P39338 YJGN_ECOLI Inner membrane protein YjgN yjgN b4257 JW5759 yjgN 44,900 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P37660 YHJV_ECOLI Inner membrane transport protein YhjV yhjV b3539 JW3508 yhjV 47,258 amino acid transmembrane transport [GO:0003333]; response to radiation [GO:0009314] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; amino acid transmembrane transport [GO:0003333]; response to radiation [GO:0009314] GO:0003333; GO:0005886; GO:0009314; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P37617 ZNTA_ECOLI Zinc/cadmium/lead-transporting P-type ATPase (EC 7.2.2.-) (EC 7.2.2.12) (EC 7.2.2.21) (Pb(II)/Cd(II)/Zn(II)-translocating ATPase) (Zn(2+)/Cd(2+)/Pb(2+) export ATPase) zntA yhhO b3469 JW3434 yhhO zntA 76,840 cobalt ion transport [GO:0006824]; detoxification of zinc ion [GO:0010312]; lead ion transport [GO:0015692]; response to cadmium ion [GO:0046686]; zinc ion transport [GO:0006829] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; cadmium ion transmembrane transporter activity [GO:0015086]; cobalt ion transmembrane transporter activity [GO:0015087]; lead ion transmembrane transporter activity [GO:0015094]; metal ion binding [GO:0046872]; nickel cation transmembrane transporter activity [GO:0015099]; P-type cadmium transporter activity [GO:0008551]; P-type zinc transporter activity [GO:0016463]; zinc ion transmembrane transporter activity [GO:0005385]; cobalt ion transport [GO:0006824]; detoxification of zinc ion [GO:0010312]; lead ion transport [GO:0015692]; response to cadmium ion [GO:0046686]; zinc ion transport [GO:0006829] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; cadmium ion transmembrane transporter activity [GO:0015086]; cobalt ion transmembrane transporter activity [GO:0015087]; lead ion transmembrane transporter activity [GO:0015094]; metal ion binding [GO:0046872]; nickel cation transmembrane transporter activity [GO:0015099]; P-type cadmium transporter activity [GO:0008551]; P-type zinc transporter activity [GO:0016463]; zinc ion transmembrane transporter activity [GO:0005385] GO:0005385; GO:0005524; GO:0005886; GO:0006824; GO:0006829; GO:0008551; GO:0010312; GO:0015086; GO:0015087; GO:0015094; GO:0015099; GO:0015692; GO:0016021; GO:0016463; GO:0016887; GO:0046686; GO:0046872 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:10660539, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:16411752, ECO:0000269|PubMed:16890908}; Multi-pass membrane protein {ECO:0000255}. +P64429 YPFJ_ECOLI Uncharacterized protein YpfJ ypfJ b2475 JW2460 ypfJ 31,460 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021] GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +A0A385XJL2 YGDT_ECOLI Protein YgdT ygdT b4610 ygdT 5,231 +P63340 YQEG_ECOLI Inner membrane transport protein YqeG yqeG b2845 JW2813 yqeG 45,099 amino acid transmembrane transport [GO:0003333] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; amino acid transmembrane transport [GO:0003333] GO:0003333; GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76224 YNJC_ECOLI Inner membrane ABC transporter permease protein YnjC ynjC b1755 JW5285 ynjC 56,243 transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transport [GO:0055085] GO:0005886; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0DPP0 YNFS_ECOLI Protein YnfS ynfS b4750 ynfS 3,193 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. +P64585 YQJE_ECOLI Inner membrane protein YqjE yqjE b3099 JW3070 yqjE 15,147 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76119 YNCI_ECOLI Putative transposase YncI yncI yncM b1459 JW1453/JW5237 b1458 yncM yncI 27,838 transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313] DNA binding [GO:0003677]; transposase activity [GO:0004803] GO:0003677; GO:0004803; GO:0006313 +P39832 ZNUB_ECOLI High-affinity zinc uptake system membrane protein ZnuB znuB yebI b1859 JW1848 yebI znuB 27,729 response to zinc ion [GO:0010043]; zinc ion import across plasma membrane [GO:0071578] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; ATPase-coupled transmembrane transporter activity [GO:0042626]; high-affinity zinc transmembrane transporter activity [GO:0000006]; response to zinc ion [GO:0010043]; zinc ion import across plasma membrane [GO:0071578] ATPase-coupled transmembrane transporter activity [GO:0042626]; high-affinity zinc transmembrane transporter activity [GO:0000006] GO:0000006; GO:0005886; GO:0005887; GO:0010043; GO:0042626; GO:0043190; GO:0071578 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0A8Z7 YQIA_ECOLI Esterase YqiA (EC 3.1.-.-) yqiA yzzI b3031 JW2999 yzzI yqiA 21,642 carboxylic ester hydrolase activity [GO:0052689]; hydrolase activity, acting on ester bonds [GO:0016788] carboxylic ester hydrolase activity [GO:0052689]; hydrolase activity, acting on ester bonds [GO:0016788] GO:0016788; GO:0052689 +P0A8F8 UVRB_ECOLI UvrABC system protein B (Protein UvrB) (Excinuclease ABC subunit B) uvrB b0779 JW0762 uvrB 76,226 nucleotide-excision repair [GO:0006289]; response to radiation [GO:0009314]; SOS response [GO:0009432] cytoplasm [GO:0005737]; excinuclease repair complex [GO:0009380] cytoplasm [GO:0005737]; excinuclease repair complex [GO:0009380]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; DNA binding [GO:0003677]; excinuclease ABC activity [GO:0009381]; identical protein binding [GO:0042802]; nucleotide-excision repair [GO:0006289]; response to radiation [GO:0009314]; SOS response [GO:0009432] ATPase activity [GO:0016887]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; excinuclease ABC activity [GO:0009381]; identical protein binding [GO:0042802] GO:0003677; GO:0005524; GO:0005737; GO:0006289; GO:0009314; GO:0009380; GO:0009381; GO:0009432; GO:0016887; GO:0042802 SUBCELLULAR LOCATION: Cytoplasm. +P77300 XYNR_ECOLI HTH-type transcriptional regulator XynR (Regulator of xylonate catabolism) xynR yagI b0272 JW0265 yagI xynR 27,838 negative regulation of transcription, DNA-templated [GO:0045892]; single-species biofilm formation [GO:0044010] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; negative regulation of transcription, DNA-templated [GO:0045892]; single-species biofilm formation [GO:0044010] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0003677; GO:0003700; GO:0044010; GO:0045892 +P0ACD2 WCAF_ECOLI Putative colanic acid biosynthesis acetyltransferase WcaF (EC 2.3.1.-) wcaF b2054 JW2039 wcaF 19,962 colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103]; single-species biofilm formation [GO:0044010]; slime layer polysaccharide biosynthetic process [GO:0045228] O-acetyltransferase activity [GO:0016413]; O-acyltransferase activity [GO:0008374]; colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103]; single-species biofilm formation [GO:0044010]; slime layer polysaccharide biosynthetic process [GO:0045228] O-acetyltransferase activity [GO:0016413]; O-acyltransferase activity [GO:0008374] GO:0008374; GO:0009103; GO:0009242; GO:0016413; GO:0044010; GO:0045228 +P77414 WCAA_ECOLI Putative colanic acid biosynthesis glycosyl transferase WcaA wcaA b2059 JW2044 wcaA 33,035 colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] glucuronosyltransferase activity [GO:0015020]; transferase activity, transferring glycosyl groups [GO:0016757]; colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103]; slime layer polysaccharide biosynthetic process [GO:0045228] glucuronosyltransferase activity [GO:0015020]; transferase activity, transferring glycosyl groups [GO:0016757] GO:0009103; GO:0009242; GO:0015020; GO:0016757; GO:0045228 +P75810 YBJJ_ECOLI Inner membrane protein YbjJ ybjJ b0845 JW0829 ybjJ 41,852 integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016020; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P0AB03 YCBJ_ECOLI Uncharacterized protein YcbJ ycbJ b0919 JW0902 ycbJ 34,488 +P77554 YAHJ_ECOLI Uncharacterized protein YahJ yahJ b0324 JW0316 yahJ 50,549 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [GO:0016814] hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [GO:0016814] GO:0016814 +P75617 YAAW_ECOLI UPF0174 protein YaaW yaaW b0011 JW0010 yaaW 26,665 +P21367 YCAC_ECOLI Probable hydrolase YcaC (EC 4.-.-.-) ycaC b0897 JW0880 ycaC 23,100 cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; lyase activity [GO:0016829] hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; lyase activity [GO:0016829] GO:0005829; GO:0016020; GO:0016787; GO:0016829; GO:0042802 +P0AAC6 YCCA_ECOLI Modulator of FtsH protease YccA yccA b0970 JW0953 yccA 23,363 negative regulation of apoptotic process [GO:0043066]; regulation of proteolysis [GO:0030162] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; negative regulation of apoptotic process [GO:0043066]; regulation of proteolysis [GO:0030162] GO:0005886; GO:0016021; GO:0030162; GO:0043066 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. Note=There are conflicting results regarding the localization of the C-terminus of this protein: According to a report, the C-terminus localizes in the periplasm (PubMed:10357810). Another report gives the C-terminus in the cytoplasm (PubMed:15919996). We show the periplasmic location. {ECO:0000269|PubMed:10357810, ECO:0000269|PubMed:15919996}. +P77301 YBAP_ECOLI Uncharacterized protein YbaP ybaP b0482 JW0471 ybaP 29,902 +P33669 YBBD_ECOLI Putative uncharacterized protein YbbD ybbD b0501 JW0489 ybbD 10,052 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021] GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P77656 YFDK_ECOLI Uncharacterized protein YfdK yfdK b2354 JW2350 yfdK 16,408 response to oxidative stress [GO:0006979] response to oxidative stress [GO:0006979] GO:0006979 +Q46835 YGHG_ECOLI Lipoprotein YghG (Putative pilotin YghG) yghG b2971 JW2938 yghG 14,670 cellular response to DNA damage stimulus [GO:0006974] cell outer membrane [GO:0009279] cell outer membrane [GO:0009279]; cellular response to DNA damage stimulus [GO:0006974] GO:0006974; GO:0009279 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250|UniProtKB:E3PJ88}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P64471 YDHI_ECOLI Uncharacterized protein YdhI ydhI b1643 JW1635 ydhI 8,891 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0ACY1 YDJA_ECOLI Putative NAD(P)H nitroreductase YdjA (EC 1.-.-.-) ydjA b1765 JW1754 ydjA 20,059 cytosol [GO:0005829] cytosol [GO:0005829]; FMN binding [GO:0010181]; oxidoreductase activity [GO:0016491] FMN binding [GO:0010181]; oxidoreductase activity [GO:0016491] GO:0005829; GO:0010181; GO:0016491 +P33343 YEHD_ECOLI Uncharacterized fimbrial-like protein YehD yehD b2111 JW2098 yehD 19,061 cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0007155; GO:0009289; GO:0043709; GO:0043711 +P45848 YCIQ_ECOLI Uncharacterized protein YciQ yciQ yciP b1268 JW5197 yciP yciQ 71,289 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 +P77171 YDCI_ECOLI Uncharacterized HTH-type transcriptional regulator YdcI ydcI b1422 JW5226 ydcI 33,402 negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] cytosol [GO:0005829] cytosol [GO:0005829]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0000986; GO:0003677; GO:0003700; GO:0005829; GO:0006355; GO:0043565; GO:0045892 +P33353 YEHQ_ECOLI Protein YehQ yehQ b2122 JW2110 yehQ 67,730 cytosol [GO:0005829] cytosol [GO:0005829]; zinc ion binding [GO:0008270] zinc ion binding [GO:0008270] GO:0005829; GO:0008270 +O52982 YFJS_ECOLI Lipoprotein YfjS yfjS b2636 JW5921 yfjS 16,735 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305|PubMed:15252048}; Lipid-anchor {ECO:0000305|PubMed:15252048}. +P65807 YGEY_ECOLI Uncharacterized protein YgeY ygeY b2872 JW2840 ygeY 44,804 metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] GO:0008237; GO:0046872 +P64483 YEAK_ECOLI Uncharacterized protein YeaK yeaK b1787 JW1776 yeaK 17,851 positive regulation of translational fidelity [GO:0045903] aminoacyl-tRNA editing activity [GO:0002161]; Ser-tRNA(Ala) hydrolase activity [GO:0002196]; positive regulation of translational fidelity [GO:0045903] aminoacyl-tRNA editing activity [GO:0002161]; Ser-tRNA(Ala) hydrolase activity [GO:0002196] GO:0002161; GO:0002196; GO:0045903 +P76057 YDAQ_ECOLI Uncharacterized protein YdaQ ydaQ b1346 JW5207 ydaQ 8,456 provirus excision [GO:0032359] sequence-specific double-stranded DNA binding [GO:1990837]; provirus excision [GO:0032359] sequence-specific double-stranded DNA binding [GO:1990837] GO:0032359; GO:1990837 +P0DSH4 YIBY_ECOLI Protein YibY yibY b4796 yibY 4,027 +P37348 YECE_ECOLI UPF0759 protein YecE yecE b1868 JW1857 yecE 31,479 +P24238 YEBB_ECOLI Uncharacterized protein YebB yebB b1862 JW5306 yebB 22,704 +P77601 YKGA_ECOLI Putative HTH-type transcriptional regulator YkgA ykgA b0300 JW5037 ykgA 28,475 DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0043565 +P39359 YJHH_ECOLI Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhH (EC 4.1.2.28) yjhH b4298 JW5775 yjhH 32,722 aldonic acid catabolic process [GO:0046176] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 2-dehydro-3-deoxy-D-pentonate aldolase activity [GO:0047440]; aldonic acid catabolic process [GO:0046176] 2-dehydro-3-deoxy-D-pentonate aldolase activity [GO:0047440] GO:0005737; GO:0046176; GO:0047440 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +Q2M7X4 YICS_ECOLI Uncharacterized protein YicS yicS b4555 JW5965 yicS 11,070 +P76335 YEDS_ECOLI Putative outer membrane protein YedS yedS b4496 JW5319/JW1948/JW1949 b1964/b1965/b1966 yedS 17,296 ion transmembrane transport [GO:0034220] cell outer membrane [GO:0009279]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; pore complex [GO:0046930]; porin activity [GO:0015288]; ion transmembrane transport [GO:0034220] porin activity [GO:0015288] GO:0009279; GO:0015288; GO:0034220; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. +P0ADX7 YHHA_ECOLI Uncharacterized protein YhhA (ORFQ) yhhA b3448 JW3413 yhhA 16,624 +P18390 YJJA_ECOLI Uncharacterized protein YjjA (Protein P-18) yjjA b4360 JW5795 yjjA 17,353 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P76230 YDJK_ECOLI Putative metabolite transport protein YdjK ydjK b1775 JW5290 ydjK 49,602 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0AB35 YCFJ_ECOLI Uncharacterized protein YcfJ ycfJ b1110 JW1096 ycfJ 18,920 regulation of single-species biofilm formation [GO:1900190] integral component of membrane [GO:0016021]; outer membrane [GO:0019867] integral component of membrane [GO:0016021]; outer membrane [GO:0019867]; regulation of single-species biofilm formation [GO:1900190] GO:0016021; GO:0019867; GO:1900190 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P45537 YHFK_ECOLI Uncharacterized protein YhfK yhfK b3358 JW5701 yhfK 79,972 transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; transmembrane transport [GO:0055085] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0016021; GO:0022857; GO:0055085 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P64542 YPEC_ECOLI Uncharacterized protein YpeC ypeC b2390 JW2387 ypeC 13,263 +P76173 YNFH_ECOLI Anaerobic dimethyl sulfoxide reductase chain YnfH (DMSO reductase anchor subunit YnfH) ynfH b1590 JW5261 ynfH 30,524 anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061] dimethyl sulfoxide reductase complex [GO:0009390]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] dimethyl sulfoxide reductase complex [GO:0009390]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; dimethyl sulfoxide reductase activity [GO:0009389]; anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061] dimethyl sulfoxide reductase activity [GO:0009389] GO:0005886; GO:0009061; GO:0009389; GO:0009390; GO:0016021; GO:0019645 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. +P76172 YNFD_ECOLI Uncharacterized protein YnfD ynfD b1586 JW5259 ynfD 10,477 +P76655 YQIG_ECOLI Putative outer membrane usher protein YqiG yqiG b3046 JW5507 yqiG 91,792 pilus assembly [GO:0009297] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; fimbrial usher porin activity [GO:0015473]; pilus assembly [GO:0009297] fimbrial usher porin activity [GO:0015473] GO:0009279; GO:0009297; GO:0015473; GO:0016021 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. +P0A862 TPX_ECOLI Thiol peroxidase (Tpx) (EC 1.11.1.24) (Peroxiredoxin tpx) (Prx) (Scavengase p20) (Thioredoxin peroxidase) (Thioredoxin-dependent peroxiredoxin) tpx yzzJ b1324 JW1317 yzzJ tpx 17,835 cellular response to oxidative stress [GO:0034599] cytoplasm [GO:0005737]; cytosol [GO:0005829]; periplasmic space [GO:0042597] cytoplasm [GO:0005737]; cytosol [GO:0005829]; periplasmic space [GO:0042597]; hydroperoxide reductase activity [GO:0032843]; thioredoxin peroxidase activity [GO:0008379]; cellular response to oxidative stress [GO:0034599] hydroperoxide reductase activity [GO:0032843]; thioredoxin peroxidase activity [GO:0008379] GO:0005737; GO:0005829; GO:0008379; GO:0032843; GO:0034599; GO:0042597 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:7499381}. Cytoplasm {ECO:0000269|PubMed:19054092}. Note=Forms a mixed disulfide with cytoplasmic thioredoxin (trx1). {ECO:0000269|PubMed:19054092}. +P26602 UBIC_ECOLI Chorismate pyruvate-lyase (CL) (CPL) (EC 4.1.3.40) ubiC b4039 JW5713 ubiC 18,777 pyruvate biosynthetic process [GO:0042866]; ubiquinone biosynthetic process [GO:0006744] cytosol [GO:0005829] cytosol [GO:0005829]; chorismate lyase activity [GO:0008813]; pyruvate biosynthetic process [GO:0042866]; ubiquinone biosynthetic process [GO:0006744] chorismate lyase activity [GO:0008813] GO:0005829; GO:0006744; GO:0008813; GO:0042866 SUBCELLULAR LOCATION: Cytoplasm. +P39161 UXUR_ECOLI Uxu operon transcriptional regulator uxuR b4324 JW4287 uxuR 29,308 transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; transcription, DNA-templated [GO:0006351] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006351 +P0AAV8 YBHH_ECOLI Putative isomerase YbhH (EC 5.-.-.-) ybhH b0769 JW0752 ybhH 37,060 isomerase activity [GO:0016853] isomerase activity [GO:0016853] GO:0016853 +P75770 YBHN_ECOLI Inner membrane protein YbhN ybhN b0788 JW0771 ybhN 35,860 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +Q47147 YAFJ_ECOLI Putative glutamine amidotransferase YafJ (EC 2.4.2.-) yafJ b0223 JW0213 yafJ 28,636 glutamine metabolic process [GO:0006541] transferase activity [GO:0016740]; glutamine metabolic process [GO:0006541] transferase activity [GO:0016740] GO:0006541; GO:0016740 +P36661 YCCE_ECOLI Uncharacterized protein YccE (ORF-D) yccE b1001 JW0986 yccE 48,355 +P77219 YAHC_ECOLI Uncharacterized protein YahC yahC b0317 JW0309 yahC 17,311 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0AAU5 YBFB_ECOLI Uncharacterized protein YbfB ybfB b0702 JW0691 ybfB 12,557 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0A898 YBEY_ECOLI Endoribonuclease YbeY (EC 3.1.-.-) ybeY b0659 JW0656 ybeY 17,526 endonucleolytic cleavage involved in rRNA processing [GO:0000478]; maturation of SSU-rRNA [GO:0030490]; response to heat [GO:0009408]; ribosomal small subunit biogenesis [GO:0042274]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; transcription antitermination [GO:0031564]; translation [GO:0006412] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; endoribonuclease activity, producing 3'-phosphomonoesters [GO:0016892]; metalloendopeptidase activity [GO:0004222]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270]; endonucleolytic cleavage involved in rRNA processing [GO:0000478]; maturation of SSU-rRNA [GO:0030490]; response to heat [GO:0009408]; ribosomal small subunit biogenesis [GO:0042274]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; transcription antitermination [GO:0031564]; translation [GO:0006412] endoribonuclease activity, producing 3'-phosphomonoesters [GO:0016892]; metalloendopeptidase activity [GO:0004222]; nickel cation binding [GO:0016151]; zinc ion binding [GO:0008270] GO:0000478; GO:0004222; GO:0005737; GO:0006364; GO:0006412; GO:0008270; GO:0009408; GO:0016151; GO:0016892; GO:0030490; GO:0031564; GO:0042254; GO:0042274 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00009, ECO:0000269|PubMed:20639334}. +P33128 YADV_ECOLI Probable fimbrial chaperone YadV yadV ecpD b0140 JW0136 ecpD yadV 27,054 cell adhesion [GO:0007155]; cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; cell adhesion [GO:0007155]; cell wall organization [GO:0071555]; chaperone-mediated protein folding [GO:0061077]; pilus organization [GO:0043711] GO:0007155; GO:0030288; GO:0043711; GO:0061077; GO:0071555 SUBCELLULAR LOCATION: Periplasm {ECO:0000250}. +P67729 YFEO_ECOLI Putative ion-transport protein YfeO yfeO b2389 JW2386 yfeO 43,574 chloride transport [GO:0006821] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; voltage-gated chloride channel activity [GO:0005247]; chloride transport [GO:0006821] voltage-gated chloride channel activity [GO:0005247] GO:0005247; GO:0005886; GO:0006821; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P76514 YFDR_ECOLI Uncharacterized protein YfdR yfdR b2361 JW2358 yfdR 20,255 5'-deoxynucleotidase activity [GO:0002953]; cobalt ion binding [GO:0050897] 5'-deoxynucleotidase activity [GO:0002953]; cobalt ion binding [GO:0050897] GO:0002953; GO:0050897 +P76515 YFDS_ECOLI Uncharacterized protein YfdS yfdS b2362 JW2359 yfdS 13,672 response to oxidative stress [GO:0006979] response to oxidative stress [GO:0006979] GO:0006979 +P0ADM4 YIDQ_ECOLI Uncharacterized protein YidQ yidQ b3688 JW5633 yidQ 11,826 cellular response to DNA damage stimulus [GO:0006974] cellular response to DNA damage stimulus [GO:0006974] GO:0006974 +P45769 YHDZ_ECOLI Uncharacterized amino-acid ABC transporter ATP-binding protein YhdZ yhdZ b3271 JW3239 yhdZ 28,574 plasma membrane [GO:0005886] plasma membrane [GO:0005886]; ABC-type amino acid transporter activity [GO:0015424]; ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626] ABC-type amino acid transporter activity [GO:0015424]; ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0005886; GO:0015424; GO:0042626 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +A5A614 YCIZ_ECOLI UPF0509 protein YciZ yciZ b4596 JW1277 yciZ 6,441 +P0AFV0 YIBH_ECOLI Inner membrane protein YibH yibH b3597 JW3571 yibH 41,988 cellular response to DNA damage stimulus [GO:0006974]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cellular response to DNA damage stimulus [GO:0006974]; transmembrane transport [GO:0055085] GO:0005886; GO:0006974; GO:0016021; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P75991 YCGZ_ECOLI Probable two-component-system connector protein YcgZ ycgZ b1164 JW1151 ycgZ 8,769 cellular response to acidic pH [GO:0071468]; negative regulation of transcription, DNA-templated [GO:0045892] cellular response to acidic pH [GO:0071468]; negative regulation of transcription, DNA-templated [GO:0045892] GO:0045892; GO:0071468 +P76692 YZGL_ECOLI Protein YzgL yzgL b3427 JW3390 yzgL 10,129 +P39325 YTFQ_ECOLI Galactofuranose-binding protein YtfQ ytfQ b4227 JW4186 ytfQ 34,345 galactose transmembrane transport [GO:0015757] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; galactose binding [GO:0005534]; galactose transmembrane transport [GO:0015757] galactose binding [GO:0005534] GO:0005534; GO:0015757; GO:0030288 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:19744923}. +P0DSH0 YRIB_ECOLI Protein YriB yriB b4792 yriB 2,925 +P77396 YPDC_ECOLI Uncharacterized HTH-type transcriptional regulator YpdC ypdC b2382 JW2379 ypdC 32,356 DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] DNA-binding transcription factor activity [GO:0003700]; sequence-specific DNA binding [GO:0043565] GO:0003700; GO:0043565 +Q46941 YQEH_ECOLI Uncharacterized protein YqeH yqeH b2846 JW5454 yqeH 24,287 regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677] GO:0003677; GO:0006355 +P0DSF1 YNAN_ECOLI Protein YnaN ynaN b4773 ynaN 1,992 +P64588 YQJI_ECOLI Transcriptional regulator YqjI yqjI b3071 JW3042 yqjI 23,401 cellular response to DNA damage stimulus [GO:0006974]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; cellular response to DNA damage stimulus [GO:0006974]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0005829; GO:0006974; GO:0045892; GO:0045893 +P33225 TORA_ECOLI Trimethylamine-N-oxide reductase 1 (TMAO reductase 1) (Trimethylamine oxidase 1) (EC 1.7.2.3) torA b0997 JW0982 torA 94,456 aerobic respiration [GO:0009060]; anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; electron transfer activity [GO:0009055]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; trimethylamine-N-oxide reductase (cytochrome c) activity [GO:0050626]; aerobic respiration [GO:0009060]; anaerobic electron transport chain [GO:0019645]; anaerobic respiration [GO:0009061] electron transfer activity [GO:0009055]; molybdenum ion binding [GO:0030151]; molybdopterin cofactor binding [GO:0043546]; trimethylamine-N-oxide reductase (cytochrome c) activity [GO:0050626] GO:0009055; GO:0009060; GO:0009061; GO:0019645; GO:0030151; GO:0030288; GO:0043546; GO:0050626 SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:2512991}. +P23173 TNAB_ECOLI Low affinity tryptophan permease tnaB trpP b3709 JW5619/JW5622 trpP tnaB 45,211 amino acid transmembrane transport [GO:0003333]; tryptophan catabolic process [GO:0006569] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; aromatic amino acid transmembrane transporter activity [GO:0015173]; symporter activity [GO:0015293]; amino acid transmembrane transport [GO:0003333]; tryptophan catabolic process [GO:0006569] aromatic amino acid transmembrane transporter activity [GO:0015173]; symporter activity [GO:0015293] GO:0003333; GO:0005886; GO:0005887; GO:0006569; GO:0015173; GO:0015293 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P00909 TRPC_ECOLI Tryptophan biosynthesis protein TrpCF [Includes: Indole-3-glycerol phosphate synthase (IGPS) (EC 4.1.1.48); N-(5'-phospho-ribosyl)anthranilate isomerase (PRAI) (EC 5.3.1.24)] trpC trpF b1262 JW1254 trpF trpC 49,492 tryptophan biosynthetic process [GO:0000162] indole-3-glycerol-phosphate synthase activity [GO:0004425]; phosphoribosylanthranilate isomerase activity [GO:0004640]; tryptophan biosynthetic process [GO:0000162] indole-3-glycerol-phosphate synthase activity [GO:0004425]; phosphoribosylanthranilate isomerase activity [GO:0004640] GO:0000162; GO:0004425; GO:0004640 +P07649 TRUA_ECOLI tRNA pseudouridine synthase A (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (PSU-I) (tRNA-uridine isomerase I) truA asuC hisT leuK b2318 JW2315 asuC hisT leuK truA 30,400 tRNA pseudouridine synthesis [GO:0031119] pseudouridine synthase activity [GO:0009982]; tRNA binding [GO:0000049]; tRNA pseudouridine synthase activity [GO:0106029]; tRNA pseudouridine synthesis [GO:0031119] pseudouridine synthase activity [GO:0009982]; tRNA binding [GO:0000049]; tRNA pseudouridine synthase activity [GO:0106029] GO:0000049; GO:0009982; GO:0031119; GO:0106029 +P39306 ULAF_ECOLI L-ribulose-5-phosphate 4-epimerase UlaF (EC 5.1.3.4) (L-ascorbate utilization protein F) (Phosphoribulose isomerase) ulaF sgaE yjfX b4198 JW4156 sgaE yjfX ulaF 25,278 L-ascorbic acid catabolic process [GO:0019854]; L-ascorbic acid metabolic process [GO:0019852]; pentose catabolic process [GO:0019323] cytosol [GO:0005829] cytosol [GO:0005829]; aldehyde-lyase activity [GO:0016832]; L-ribulose-phosphate 4-epimerase activity [GO:0008742]; zinc ion binding [GO:0008270]; L-ascorbic acid catabolic process [GO:0019854]; L-ascorbic acid metabolic process [GO:0019852]; pentose catabolic process [GO:0019323] aldehyde-lyase activity [GO:0016832]; L-ribulose-phosphate 4-epimerase activity [GO:0008742]; zinc ion binding [GO:0008270] GO:0005829; GO:0008270; GO:0008742; GO:0016832; GO:0019323; GO:0019852; GO:0019854 +P0A9M5 XGPT_ECOLI Xanthine-guanine phosphoribosyltransferase (XGPRT) (EC 2.4.2.-) (EC 2.4.2.22) (Xanthine phosphoribosyltransferase) gpt gpp gxu b0238 JW0228 gpp gxu gpt 16,971 GMP salvage [GO:0032263]; IMP salvage [GO:0032264]; protein homotetramerization [GO:0051289]; XMP salvage [GO:0032265] cytosol [GO:0005829]; plasma membrane [GO:0005886] cytosol [GO:0005829]; plasma membrane [GO:0005886]; guanine phosphoribosyltransferase activity [GO:0052657]; guanosine tetraphosphate binding [GO:0097216]; hypoxanthine phosphoribosyltransferase activity [GO:0004422]; magnesium ion binding [GO:0000287]; xanthine phosphoribosyltransferase activity [GO:0000310]; GMP salvage [GO:0032263]; IMP salvage [GO:0032264]; protein homotetramerization [GO:0051289]; XMP salvage [GO:0032265] guanine phosphoribosyltransferase activity [GO:0052657]; guanosine tetraphosphate binding [GO:0097216]; hypoxanthine phosphoribosyltransferase activity [GO:0004422]; magnesium ion binding [GO:0000287]; xanthine phosphoribosyltransferase activity [GO:0000310] GO:0000287; GO:0000310; GO:0004422; GO:0005829; GO:0005886; GO:0032263; GO:0032264; GO:0032265; GO:0051289; GO:0052657; GO:0097216 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P09099 XYLB_ECOLI Xylulose kinase (XK) (Xylulokinase) (EC 2.7.1.17) (1-deoxy-D-xylulokinase) (EC 2.7.1.-) xylB b3564 JW3536 xylB 52,618 D-xylose catabolic process [GO:0042843]; xylulose catabolic process [GO:0005998] 1-deoxy-D-xylulose kinase activity [GO:0103020]; ATP binding [GO:0005524]; xylulokinase activity [GO:0004856]; D-xylose catabolic process [GO:0042843]; xylulose catabolic process [GO:0005998] 1-deoxy-D-xylulose kinase activity [GO:0103020]; ATP binding [GO:0005524]; xylulokinase activity [GO:0004856] GO:0004856; GO:0005524; GO:0005998; GO:0042843; GO:0103020 +P0AAB2 WZB_ECOLI Low molecular weight protein-tyrosine-phosphatase Wzb (EC 3.1.3.48) wzb b2061 JW2046 wzb 16,709 colanic acid biosynthetic process [GO:0009242] protein tyrosine phosphatase activity [GO:0004725]; colanic acid biosynthetic process [GO:0009242] protein tyrosine phosphatase activity [GO:0004725] GO:0004725; GO:0009242 +P08957 T1MK_ECOLI Type I restriction enzyme EcoKI M protein (M.EcoKI) (EC 2.1.1.72) hsdM hsm b4349 JW4312 hsm hsdM 59,307 DNA restriction-modification system [GO:0009307]; viral process [GO:0016032] cytosol [GO:0005829] cytosol [GO:0005829]; DNA binding [GO:0003677]; N-methyltransferase activity [GO:0008170]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007]; DNA restriction-modification system [GO:0009307]; viral process [GO:0016032] DNA binding [GO:0003677]; N-methyltransferase activity [GO:0008170]; site-specific DNA-methyltransferase (adenine-specific) activity [GO:0009007] GO:0003677; GO:0005829; GO:0008170; GO:0009007; GO:0009307; GO:0016032 +P13482 TREA_ECOLI Periplasmic trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase) (Tre37A) treA osmA b1197 JW1186 osmA treA 63,637 cellular hyperosmotic response [GO:0071474]; cellular response to DNA damage stimulus [GO:0006974]; trehalose catabolic process [GO:0005993] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; alpha,alpha-trehalase activity [GO:0004555]; cellular hyperosmotic response [GO:0071474]; cellular response to DNA damage stimulus [GO:0006974]; trehalose catabolic process [GO:0005993] alpha,alpha-trehalase activity [GO:0004555] GO:0004555; GO:0005993; GO:0006974; GO:0030288; GO:0071474 SUBCELLULAR LOCATION: Periplasm. +P0AC35 TTDB_ECOLI L(+)-tartrate dehydratase subunit beta (L-TTD beta) (EC 4.2.1.32) ttdB ygjB b3062 JW3034 ygjB ttdB 22,679 response to heat [GO:0009408] L(+)-tartrate dehydratase activity [GO:0008730]; response to heat [GO:0009408] L(+)-tartrate dehydratase activity [GO:0008730] GO:0008730; GO:0009408 +P07650 TYPH_ECOLI Thymidine phosphorylase (EC 2.4.2.4) (TdRPase) deoA tpp ttg b4382 JW4345 tpp ttg deoA 47,207 cellular response to DNA damage stimulus [GO:0006974]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside metabolic process [GO:0006213]; thymidine metabolic process [GO:0046104] cytosol [GO:0005829]; membrane [GO:0016020] cytosol [GO:0005829]; membrane [GO:0016020]; 1,4-alpha-oligoglucan phosphorylase activity [GO:0004645]; pyrimidine-nucleoside phosphorylase activity [GO:0016154]; thymidine phosphorylase activity [GO:0009032]; cellular response to DNA damage stimulus [GO:0006974]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside metabolic process [GO:0006213]; thymidine metabolic process [GO:0046104] 1,4-alpha-oligoglucan phosphorylase activity [GO:0004645]; pyrimidine-nucleoside phosphorylase activity [GO:0016154]; thymidine phosphorylase activity [GO:0009032] GO:0004645; GO:0005829; GO:0006206; GO:0006213; GO:0006974; GO:0009032; GO:0016020; GO:0016154; GO:0046104 +P45570 YBCI_ECOLI Inner membrane protein YbcI ybcI b0527 JW0516 ybcI 19,530 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P64435 YBCW_ECOLI Uncharacterized protein YbcW ybcW b0559 JW0548 ybcW 7,624 +P76510 YFDN_ECOLI Uncharacterized protein YfdN yfdN yzyA b2357 JW5385 yzyA yfdN 18,766 +P0ACW8 YDFA_ECOLI Uncharacterized protein YdfA ydfA b1571 JW1563 ydfA 5,792 +P77196 YFCU_ECOLI Putative outer membrane usher protein YfcU yfcU yfcT b4661 JW2334/JW2335 b2337 b2338 yfcT yfcU 97,490 pilus assembly [GO:0009297] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; fimbrial usher porin activity [GO:0015473]; pilus assembly [GO:0009297] fimbrial usher porin activity [GO:0015473] GO:0009279; GO:0009297; GO:0015473; GO:0016021 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. +P76160 YDFR_ECOLI Uncharacterized protein YdfR ydfR b1555 JW1547 ydfR 12,091 +P77260 YDFI_ECOLI Uncharacterized oxidoreductase YdfI (EC 1.-.-.-) ydfI b1542 JW1535 ydfI 53,685 mannitol metabolic process [GO:0019594] oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; mannitol metabolic process [GO:0019594] oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] GO:0016616; GO:0019594 +A5A617 YDGU_ECOLI Uncharacterized protein YdgU ydgU b4601 JW1589 ydgU 3,236 +P0ADM0 YIDH_ECOLI Inner membrane protein YidH yidH b3676 JW3652 yidH 12,779 response to oxidative stress [GO:0006979] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; response to oxidative stress [GO:0006979] GO:0005886; GO:0006979; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76547 YFFP_ECOLI Uncharacterized protein YffP yffP b2447 yffP 22,907 +P64614 YHCN_ECOLI Uncharacterized protein YhcN yhcN b3238 JW5540 yhcN 9,196 cellular response to acidic pH [GO:0071468]; cellular response to hydrogen peroxide [GO:0070301]; single-species biofilm formation on inanimate substrate [GO:0044011] periplasmic space [GO:0042597] periplasmic space [GO:0042597]; cellular response to acidic pH [GO:0071468]; cellular response to hydrogen peroxide [GO:0070301]; single-species biofilm formation on inanimate substrate [GO:0044011] GO:0042597; GO:0044011; GO:0070301; GO:0071468 SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. +P42624 YHAK_ECOLI Pirin-like protein YhaK yhaK b3106 JW3077 yhaK 25,895 cytoplasm [GO:0005737] cytoplasm [GO:0005737] GO:0005737 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:18561187}. +P76485 YFBO_ECOLI Uncharacterized protein YfbO yfbO b2274 JW2269 yfbO 16,163 +P76471 YFAZ_ECOLI Outer membrane protein YfaZ yfaZ b2250 JW5371 yfaZ 18,610 cell outer membrane [GO:0009279] cell outer membrane [GO:0009279] GO:0009279 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:16522795}. +P0AFU2 YFBS_ECOLI Uncharacterized transporter YfbS yfbS b2292 JW2289 yfbS 65,872 potassium ion transport [GO:0006813] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cation transmembrane transporter activity [GO:0008324]; potassium ion transport [GO:0006813] cation transmembrane transporter activity [GO:0008324] GO:0005886; GO:0006813; GO:0008324; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P52140 YFJY_ECOLI UPF0758 protein YfjY yfjY b2644 JW2625 yfjY 17,964 metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] GO:0008237; GO:0046872 +P0DSH5 YICU_ECOLI Protein YicU yicU b4797 yicU 2,183 +P33924 YEJO_ECOLI Putative uncharacterized outer membrane protein YejO yejO b2190 JW5839 yejO 91,202 cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] GO:0009279; GO:0016021 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. +P75992 YMGA_ECOLI Probable two-component-system connector protein YmgA ymgA b1165 JW1152 ymgA 10,345 negative regulation of single-species biofilm formation [GO:1900191] negative regulation of single-species biofilm formation [GO:1900191] GO:1900191 +P33346 YEHI_ECOLI Uncharacterized protein YehI yehI b2118 JW2105 yehI 138,068 +Q46789 YGEI_ECOLI Uncharacterized protein YgeI ygeI b2853 JW5456 ygeI 8,055 +P31808 YCIK_ECOLI Uncharacterized oxidoreductase YciK (EC 1.-.-.-) yciK b1271 JW1263 yciK 27,933 cytosol [GO:0005829] cytosol [GO:0005829]; oxidoreductase activity [GO:0016491] oxidoreductase activity [GO:0016491] GO:0005829; GO:0016491 +P27843 YIGG_ECOLI Inner membrane protein YigG yigG b3818 JW5590 yigG 14,408 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] GO:0005886; GO:0005887 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:11867724}; Multi-pass membrane protein {ECO:0000269|PubMed:11867724}. +P0DPO0 YMGM_ECOLI Protein YmgM ymgM b4740 ymgM 7,677 +P39358 YJHG_ECOLI D-xylonate dehydratase YjhG (EC 4.2.1.82) yjhG b4297 JW4259 yjhG 70,017 aldonic acid catabolic process [GO:0046176] cytosol [GO:0005829] cytosol [GO:0005829]; hydro-lyase activity [GO:0016836]; xylonate dehydratase activity [GO:0050401]; aldonic acid catabolic process [GO:0046176] hydro-lyase activity [GO:0016836]; xylonate dehydratase activity [GO:0050401] GO:0005829; GO:0016836; GO:0046176; GO:0050401 +P25531 YICR_ECOLI UPF0758 protein YicR yicR b3638 JW5643 yicR 25,343 metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237] GO:0008237; GO:0046872 +P32160 YIIQ_ECOLI Uncharacterized protein YiiQ yiiQ b3920 JW3891 yiiQ 21,763 +P75675 YKFJ_ECOLI Putative uncharacterized protein YkfJ ykfJ b0235 JW0225 ykfJ 9,820 RNA processing [GO:0006396] RNA ligase activity [GO:0008452]; RNA processing [GO:0006396] RNA ligase activity [GO:0008452] GO:0006396; GO:0008452 +P46852 YHHW_ECOLI Quercetin 2,3-dioxygenase (Quercetinase) (EC 1.13.11.24) (Pirin-like protein YhhW) yhhW b3439 JW3402 yhhW 26,279 metal ion binding [GO:0046872]; quercetin 2,3-dioxygenase activity [GO:0008127] metal ion binding [GO:0046872]; quercetin 2,3-dioxygenase activity [GO:0008127] GO:0008127; GO:0046872 +P39376 YJIE_ECOLI HTH-type transcriptional regulator YjiE (Hypochlorite-response regulator protein YjiE) (Quorum-sensing regulator protein D) yjiE qseD b4327 JW4290 qseD yjiE 34,711 regulation of transcription, DNA-templated [GO:0006355] bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding [GO:0000984]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; regulation of transcription, DNA-templated [GO:0006355] bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding [GO:0000984]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; transcription regulatory region sequence-specific DNA binding [GO:0000976] GO:0000976; GO:0000984; GO:0003700; GO:0006355; GO:0042802 +P0ADW8 YHEV_ECOLI Uncharacterized protein YheV yheV b4551 JW3312 yheV 7,599 +P0AB52 YCHN_ECOLI Protein YchN ychN b1219 JW1210 ychN 12,693 cytosol [GO:0005829]; protein-containing complex [GO:0032991] cytosol [GO:0005829]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802] identical protein binding [GO:0042802] GO:0005829; GO:0032991; GO:0042802 +P39408 YJJV_ECOLI Uncharacterized metal-dependent hydrolase YjjV (EC 3.1.-.-) yjjV b4378 JW4341 yjjV 28,909 cytosol [GO:0005829] cytosol [GO:0005829]; endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888]; metal ion binding [GO:0046872] endodeoxyribonuclease activity, producing 5'-phosphomonoesters [GO:0016888]; metal ion binding [GO:0046872] GO:0005829; GO:0016888; GO:0046872 +P0A930 WZA_ECOLI Putative polysaccharide export protein Wza wza b2062 JW2047 wza 41,910 colanic acid metabolic process [GO:0046377]; polysaccharide biosynthetic process [GO:0000271] cell outer membrane [GO:0009279]; pore complex [GO:0046930] cell outer membrane [GO:0009279]; pore complex [GO:0046930]; polysaccharide transmembrane transporter activity [GO:0015159]; porin activity [GO:0015288]; colanic acid metabolic process [GO:0046377]; polysaccharide biosynthetic process [GO:0000271] polysaccharide transmembrane transporter activity [GO:0015159]; porin activity [GO:0015288] GO:0000271; GO:0009279; GO:0015159; GO:0015288; GO:0046377; GO:0046930 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. +P29217 YCEH_ECOLI UPF0502 protein YceH (G20.3) yceH b1067 JW1054 yceH 24,177 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P75828 YBJD_ECOLI Uncharacterized protein YbjD ybjD b0876 JW0860 ybjD 63,589 DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302] ATP binding [GO:0005524]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302] ATP binding [GO:0005524] GO:0000731; GO:0005524; GO:0006302 +P75806 YBJG_ECOLI Putative undecaprenyl-diphosphatase YbjG (EC 3.6.1.27) (Undecaprenyl pyrophosphate phosphatase) ybjG b0841 JW5112 ybjG 22,399 cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; undecaprenyl-diphosphatase activity [GO:0050380]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] undecaprenyl-diphosphatase activity [GO:0050380] GO:0005886; GO:0008360; GO:0009252; GO:0016021; GO:0046677; GO:0050380; GO:0071555 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P75818 YBJP_ECOLI Uncharacterized lipoprotein YbjP ybjP b0865 JW0849 ybjP 18,991 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. +P0AFN6 YADH_ECOLI Inner membrane transport permease YadH yadH b0128 JW0124 yadH 28,516 transmembrane transport [GO:0055085] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886] ATP-binding cassette (ABC) transporter complex [GO:0043190]; plasma membrane [GO:0005886]; transmembrane transport [GO:0055085] GO:0005886; GO:0043190; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76163 YDFV_ECOLI Uncharacterized protein YdfV ydfV b1565 JW1557 ydfV 11,308 +P77288 YFCV_ECOLI Uncharacterized fimbrial-like protein YfcV yfcV b2339 JW2336 yfcV 19,851 cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] pilus [GO:0009289] pilus [GO:0009289]; cell adhesion [GO:0007155]; cell adhesion involved in single-species biofilm formation [GO:0043709]; pilus organization [GO:0043711] GO:0007155; GO:0009289; GO:0043709; GO:0043711 +P65290 YFGH_ECOLI Uncharacterized lipoprotein YfgH yfgH b2505 JW5400 yfgH 17,705 cell outer membrane [GO:0009279]; plasma membrane [GO:0005886] cell outer membrane [GO:0009279]; plasma membrane [GO:0005886] GO:0005886; GO:0009279 SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. +P64616 YHCO_ECOLI Uncharacterized protein YhcO yhcO b3239 JW3208 yhcO 10,796 +P0AAL6 YDHY_ECOLI Uncharacterized ferredoxin-like protein YdhY ydhY b1674 JW1664 ydhY 22,367 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0046872; GO:0051539 +P64574 YGHW_ECOLI Uncharacterized protein YghW yghW b2998 JW2966 yghW 10,945 response to butan-1-ol [GO:1901422] response to butan-1-ol [GO:1901422] GO:1901422 +P0ADU2 YGIN_ECOLI Probable quinol monooxygenase YgiN (QuMo) (EC 1.-.-.-) ygiN b3029 JW2997 ygiN 11,532 response to acidic pH [GO:0010447] cytosol [GO:0005829] cytosol [GO:0005829]; catalytic activity [GO:0003824]; oxidoreductase activity [GO:0016491]; response to acidic pH [GO:0010447] catalytic activity [GO:0003824]; oxidoreductase activity [GO:0016491] GO:0003824; GO:0005829; GO:0010447; GO:0016491 +Q46841 YGHQ_ECOLI Inner membrane protein YghQ yghQ b2983 JW5490 yghQ 38,533 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76206 YDIY_ECOLI Uncharacterized protein YdiY ydiY b1722 JW1711 ydiY 27,607 +P75917 YMDA_ECOLI Uncharacterized protein YmdA ymdA b1044 JW1031 ymdA 11,194 +P09162 YJAA_ECOLI Uncharacterized protein YjaA yjaA b4011 JW3971 yjaA 14,447 cellular response to acidic pH [GO:0071468]; cellular response to hydrogen peroxide [GO:0070301]; single-species biofilm formation on inanimate substrate [GO:0044011] cellular response to acidic pH [GO:0071468]; cellular response to hydrogen peroxide [GO:0070301]; single-species biofilm formation on inanimate substrate [GO:0044011] GO:0044011; GO:0070301; GO:0071468 +P45550 YHFX_ECOLI Uncharacterized protein YhfX yhfX b3381 JW3344 yhfX 42,294 +P76220 YDJY_ECOLI Uncharacterized protein YdjY ydjY b1751 JW5283 ydjY 24,125 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P39379 YJIH_ECOLI Uncharacterized protein YjiH yjiH b4330 JW5783 yjiH 23,793 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0DSE9 YCHT_ECOLI Protein YchT ychT b4771 ychT 1,882 +P64610 YRBL_ECOLI Uncharacterized protein YrbL yrbL b3207 JW3174 yrbL 24,345 +P42915 YRAJ_ECOLI Outer membrane usher protein YraJ yraJ b3144 JW3113 yraJ 93,616 cellular response to DNA damage stimulus [GO:0006974]; pilus assembly [GO:0009297]; pilus organization [GO:0043711] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021] cell outer membrane [GO:0009279]; integral component of membrane [GO:0016021]; fimbrial usher porin activity [GO:0015473]; cellular response to DNA damage stimulus [GO:0006974]; pilus assembly [GO:0009297]; pilus organization [GO:0043711] fimbrial usher porin activity [GO:0015473] GO:0006974; GO:0009279; GO:0009297; GO:0015473; GO:0016021; GO:0043711 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. +P0DSE5 YTIB_ECOLI Protein YtiB ytiB b4767 ytiB 2,019 +P0DSH8 YTGA_ECOLI Protein YtgA ytgA b4800 ytgA 1,763 +Q46943 YQEJ_ECOLI Uncharacterized protein YqeJ yqeJ b2848 JW5455 yqeJ 18,720 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021] GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +Q2EES1 YNID_ECOLI Uncharacterized protein YniD yniD b4535 JW5911 yniD 4,115 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021] GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. +P64508 YOBF_ECOLI Protein YobF yobF b1824 JW1813 yobF 5,212 cellular response to cell envelope stress [GO:0036460]; cellular response to heat [GO:0034605]; cellular stress response to acid chemical [GO:0097533] cellular response to cell envelope stress [GO:0036460]; cellular response to heat [GO:0034605]; cellular stress response to acid chemical [GO:0097533] GO:0034605; GO:0036460; GO:0097533 +Q2EET0 YPDJ_ECOLI Protein YpdJ ypdJ b4545 JW5386 ypdJ 5,315 +P0AAJ1 YNFG_ECOLI Probable anaerobic dimethyl sulfoxide reductase chain YnfG (DMSO reductase iron-sulfur subunit YnfG) ynfG b1589 JW1581 ynfG 22,752 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872] GO:0046872; GO:0051539 +P76227 YNJH_ECOLI Uncharacterized protein YnjH ynjH b1760 JW1749 ynjH 9,947 +P42604 UXAA_ECOLI Altronate dehydratase (EC 4.2.1.7) (D-altronate hydro-lyase) uxaA ygjW b3091 JW3062 ygjW uxaA 54,093 D-galacturonate catabolic process [GO:0019698] altronate dehydratase activity [GO:0008789]; ferrous iron binding [GO:0008198]; D-galacturonate catabolic process [GO:0019698] altronate dehydratase activity [GO:0008789]; ferrous iron binding [GO:0008198] GO:0008198; GO:0008789; GO:0019698 +P43340 YCAK_ECOLI Uncharacterized NAD(P)H oxidoreductase YcaK (EC 1.6.99.-) ycaK b0901 JW0884 ycaK 23,036 cytosol [GO:0005829] cytosol [GO:0005829]; FMN binding [GO:0010181]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955] FMN binding [GO:0010181]; NAD(P)H dehydrogenase (quinone) activity [GO:0003955] GO:0003955; GO:0005829; GO:0010181 +P0A9U3 YBIT_ECOLI Probable ATP-binding protein YbiT ybiT b0820 JW0804 ybiT 59,858 ATP binding [GO:0005524] ATP binding [GO:0005524] GO:0005524 +P31679 YAAU_ECOLI Putative metabolite transport protein YaaU yaaU yabE b0045 JW0044 yabE yaaU 48,667 response to oxidative stress [GO:0006979] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; response to oxidative stress [GO:0006979] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0006979; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P52096 YAER_ECOLI Uncharacterized protein YaeR yaeR b0187 JW0182 yaeR 14,737 metal ion binding [GO:0046872] metal ion binding [GO:0046872] GO:0046872 +P0DPN0 YAHV_ECOLI Protein YahV yahV b4730 yahV 2,629 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. +P77206 YAFZ_ECOLI UPF0380 protein YafZ yafZ b0252 JW0242 yafZ 31,051 +P52044 YGFI_ECOLI Uncharacterized HTH-type transcriptional regulator YgfI ygfI b2921 JW5476 ygfI 34,674 cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0006355; GO:0006974 +P0ADL6 YIDG_ECOLI Inner membrane protein YidG yidG b3675 JW3651 yidG 13,768 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76177 YDGH_ECOLI Protein YdgH ydgH b1604 JW1596 ydgH 33,903 +P76463 YFAQ_ECOLI Uncharacterized protein YfaQ yfaQ b2226 JW2220 yfaQ 61,476 +P64572 YGHR_ECOLI Uncharacterized ATP-binding protein YghR yghR b2984 JW2952 yghR 28,151 ATP binding [GO:0005524] ATP binding [GO:0005524] GO:0005524 +P76421 YEGX_ECOLI Uncharacterized protein YegX yegX b2102 JW5345 yegX 31,604 cellular carbohydrate catabolic process [GO:0044275]; cell wall macromolecule catabolic process [GO:0016998]; peptidoglycan catabolic process [GO:0009253] lysozyme activity [GO:0003796]; cell wall macromolecule catabolic process [GO:0016998]; cellular carbohydrate catabolic process [GO:0044275]; peptidoglycan catabolic process [GO:0009253] lysozyme activity [GO:0003796] GO:0003796; GO:0009253; GO:0016998; GO:0044275 +P33015 YEEE_ECOLI UPF0394 inner membrane protein YeeE yeeE b2013 JW1995 yeeE 38,100 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76318 YEDK_ECOLI Abasic site processing protein YedK (EC 3.4.-.-) yedK yedG b1931 JW1916 yedG yedK 24,979 cellular response to DNA damage stimulus [GO:0006974]; protein-DNA covalent cross-linking [GO:0018142]; SOS response [GO:0009432] peptidase activity [GO:0008233]; single-stranded DNA binding [GO:0003697]; cellular response to DNA damage stimulus [GO:0006974]; protein-DNA covalent cross-linking [GO:0018142]; SOS response [GO:0009432] peptidase activity [GO:0008233]; single-stranded DNA binding [GO:0003697] GO:0003697; GO:0006974; GO:0008233; GO:0009432; GO:0018142 +P37671 YIAJ_ECOLI DNA-binding transcriptional repressor YiaJ (YiaKLMNOPQRS operon repressor) (YiaK-S operon repressor) yiaJ b3574 JW3546 yiaJ 31,067 negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; negative regulation of transcription, DNA-templated [GO:0045892] DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700] GO:0003677; GO:0003700; GO:0045892 +P45546 YHFT_ECOLI Uncharacterized protein YhfT yhfT b3377 JW3340 yhfT 46,516 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0DSF6 YECV_ECOLI Protein YecV yecV b4778 yecV 1,630 +P0A8Y1 YJJG_ECOLI Pyrimidine 5'-nucleotidase YjjG (EC 3.1.3.5) (House-cleaning nucleotidase) (Non-canonical pyrimidine nucleotide phosphatase) (Nucleoside 5'-monophosphate phosphohydrolase) (dUMP phosphatase) yjjG b4374 JW4336 yjjG 25,301 pyrimidine nucleobase salvage [GO:0043100]; response to xenobiotic stimulus [GO:0009410]; thymine metabolic process [GO:0019859] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; 5'-nucleotidase activity [GO:0008253]; manganese ion binding [GO:0030145]; nucleotide binding [GO:0000166]; phosphatase activity [GO:0016791]; pyrimidine nucleobase salvage [GO:0043100]; response to xenobiotic stimulus [GO:0009410]; thymine metabolic process [GO:0019859] 5'-nucleotidase activity [GO:0008253]; manganese ion binding [GO:0030145]; nucleotide binding [GO:0000166]; phosphatase activity [GO:0016791] GO:0000166; GO:0005737; GO:0008253; GO:0009410; GO:0016791; GO:0019859; GO:0030145; GO:0043100 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P0A8Y3 YIHX_ECOLI Alpha-D-glucose 1-phosphate phosphatase YihX (Alpha-D-glucose-1-P phosphatase) (EC 3.1.3.10) (Alpha-D-glucose-1-phosphatase) (Haloacid dehalogenase-like phosphatase 4) (HAD4) yihX b3885 JW5566 yihX 22,732 glucose-1-phosphatase activity [GO:0008877]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145] glucose-1-phosphatase activity [GO:0008877]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145] GO:0000287; GO:0008877; GO:0030145 +P37627 YHIJ_ECOLI Uncharacterized protein YhiJ yhiJ b3488 JW3455 yhiJ 61,164 +P45552 YHFZ_ECOLI Uncharacterized protein YhfZ yhfZ b3383 JW5948 yhfZ 33,504 +P45469 YRAR_ECOLI Putative NAD(P)-binding protein YraR yraR b3152 JW5528 yraR 23,198 NAD binding [GO:0051287]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620] NAD binding [GO:0051287]; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620] GO:0016620; GO:0051287 +Q46808 YQEB_ECOLI Uncharacterized protein YqeB yqeB b2875 JW2843 yqeB 57,682 +P0DSH1 YSAE_ECOLI Protein YsaE ysaE b4793 ysaE 2,605 +P0DSF4 YNFU_ECOLI Putative zinc-binding protein YnfU ynfU b4776 ynfU 6,371 metal ion binding [GO:0046872] metal ion binding [GO:0046872] GO:0046872 +Q46871 YQJH_ECOLI NADPH-dependent ferric-chelate reductase (EC 1.16.1.9) (Ferric siderophore reductase) yqjH b3070 JW3041 yqjH 28,872 cellular response to iron ion starvation [GO:0010106]; cellular response to nickel ion [GO:0071289]; iron import into cell [GO:0033212]; siderophore-dependent iron import into cell [GO:0033214]; siderophore transport [GO:0015891] cytosol [GO:0005829] cytosol [GO:0005829]; FAD binding [GO:0071949]; ferric-chelate reductase (NADPH) activity [GO:0052851]; flavin adenine dinucleotide binding [GO:0050660]; cellular response to iron ion starvation [GO:0010106]; cellular response to nickel ion [GO:0071289]; iron import into cell [GO:0033212]; siderophore transport [GO:0015891]; siderophore-dependent iron import into cell [GO:0033214] FAD binding [GO:0071949]; ferric-chelate reductase (NADPH) activity [GO:0052851]; flavin adenine dinucleotide binding [GO:0050660] GO:0005829; GO:0010106; GO:0015891; GO:0033212; GO:0033214; GO:0050660; GO:0052851; GO:0071289; GO:0071949 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P76214 VES_ECOLI Protein Ves (Various environmental stresses-induced protein) ves ydjR b1742 JW1731 ydjR ves 21,577 cellular response to cold [GO:0070417] cellular response to cold [GO:0070417] GO:0070417 +P77377 WZXC_ECOLI Lipopolysaccharide biosynthesis protein WzxC wzxC wzx b2046 JW2031 wzx wzxC 53,693 colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103] GO:0005886; GO:0005887; GO:0009103; GO:0009242 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +Q46801 XDHC_ECOLI Putative xanthine dehydrogenase iron-sulfur-binding subunit XdhC xdhC ygeU b2868 JW2836 ygeU xdhC 16,922 hypoxanthine catabolic process [GO:0009114]; purine ribonucleoside salvage [GO:0006166] 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; hypoxanthine catabolic process [GO:0009114]; purine ribonucleoside salvage [GO:0006166] 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872] GO:0006166; GO:0009055; GO:0009114; GO:0046872; GO:0051537 +P71241 WCAJ_ECOLI UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase (UDP-Glc:Und-P Glc-1-P transferase) (EC 2.7.8.31) (Colanic acid biosynthesis UDP-glucose lipid carrier transferase) (Glucosyl-P-P-undecaprenol synthase) wcaJ b2047 JW2032 wcaJ 52,408 colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; transferase activity, transferring glycosyl groups [GO:0016757]; undecaprenyl-phosphate glucose phosphotransferase activity [GO:0089702]; colanic acid biosynthetic process [GO:0009242]; lipopolysaccharide biosynthetic process [GO:0009103] phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; transferase activity, transferring glycosyl groups [GO:0016757]; undecaprenyl-phosphate glucose phosphotransferase activity [GO:0089702] GO:0005886; GO:0005887; GO:0009103; GO:0009242; GO:0016757; GO:0016780; GO:0089702 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:22408159}; Multi-pass membrane protein {ECO:0000269|PubMed:22408159}. +P24252 YBGA_ECOLI Uncharacterized protein YbgA (ORF169) (TKP) ybgA b0707 JW0697 ybgA 20,211 +P0AAW1 YBHP_ECOLI Uncharacterized protein YbhP ybhP b0790 JW0773 ybhP 28,790 +P75779 YBIX_ECOLI PKHD-type hydroxylase YbiX (EC 1.14.11.-) ybiX b0804 JW5105 ybiX 25,529 cellular iron ion homeostasis [GO:0006879]; cellular response to DNA damage stimulus [GO:0006974] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; cellular iron ion homeostasis [GO:0006879]; cellular response to DNA damage stimulus [GO:0006974] 2-oxoglutarate-dependent dioxygenase activity [GO:0016706]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418] GO:0005506; GO:0006879; GO:0006974; GO:0016706; GO:0031418 +Q47534 YAIO_ECOLI Outer membrane protein YaiO yaiO b0358 JW0349 yaiO 29,040 cell outer membrane [GO:0009279] cell outer membrane [GO:0009279] GO:0009279 SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:16522795}. +P77365 YAFY_ECOLI Lipoprotein YafY yafY b0251 JW0240 yafY 16,815 plasma membrane [GO:0005886] plasma membrane [GO:0005886] GO:0005886 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000269|PubMed:15252048}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000305|PubMed:15252048}. +P0A9T8 YBBA_ECOLI Uncharacterized ABC transporter ATP-binding protein YbbA ybbA b0495 JW0484 ybbA 24,533 ATP binding [GO:0005524]; ATPase-coupled transmembrane transporter activity [GO:0042626] ATPase-coupled transmembrane transporter activity [GO:0042626]; ATP binding [GO:0005524] GO:0005524; GO:0042626 +P77460 YBCY_ECOLI Putative uncharacterized protein YbcY ybcY b0562 JW0551 ybcY 21,121 methyltransferase activity [GO:0008168] methyltransferase activity [GO:0008168] GO:0008168 +P77316 YBDR_ECOLI Uncharacterized zinc-type alcohol dehydrogenase-like protein YbdR (EC 1.-.-.-) ybdR b0608 JW0601 ybdR 44,176 oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] oxidoreductase activity [GO:0016491]; zinc ion binding [GO:0008270] GO:0008270; GO:0016491 +P0DSE3 YADX_ECOLI Protein YadX yadX b4765 yadX 1,806 +P45470 YHBO_ECOLI Protein/nucleic acid deglycase 2 (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase) yhbO b3153 JW5529 yhbO 18,858 DNA repair [GO:0006281]; guanine deglycation [GO:0106044]; protein deglycation [GO:0036525]; protein repair [GO:0030091]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]; response to pH [GO:0009268]; response to UV [GO:0009411] cytosol [GO:0005829] cytosol [GO:0005829]; glyoxalase III activity [GO:0019172]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; protein deglycase activity [GO:0036524]; DNA repair [GO:0006281]; guanine deglycation [GO:0106044]; protein deglycation [GO:0036525]; protein repair [GO:0030091]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]; response to pH [GO:0009268]; response to UV [GO:0009411] glyoxalase III activity [GO:0019172]; hydrolase activity [GO:0016787]; identical protein binding [GO:0042802]; protein deglycase activity [GO:0036524] GO:0005829; GO:0006281; GO:0006979; GO:0009268; GO:0009408; GO:0009411; GO:0016787; GO:0019172; GO:0030091; GO:0036524; GO:0036525; GO:0042802; GO:0106044 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:16380269}. +P21418 YDFC_ECOLI Uncharacterized protein YdfC ydfC rzpQ b1573 JW1565 rzpQ ydfC 8,350 +P0AD35 YFDO_ECOLI Protein YfdO yfdO oweS b2358 JW2355 oweS yfdO 14,401 response to oxidative stress [GO:0006979] response to oxidative stress [GO:0006979] GO:0006979 +Q46845 YGHU_ECOLI Disulfide-bond oxidoreductase YghU (EC 1.8.4.-) (GSH-dependent disulfide-bond oxidoreductase YghU) (GST N2-2) (Organic hydroperoxidase) (EC 1.11.1.-) yghU b2989 JW5492 yghU 32,392 glutathione metabolic process [GO:0006749] disulfide oxidoreductase activity [GO:0015036]; peroxidase activity [GO:0004601]; glutathione metabolic process [GO:0006749] disulfide oxidoreductase activity [GO:0015036]; peroxidase activity [GO:0004601] GO:0004601; GO:0006749; GO:0015036 +P77549 YFCJ_ECOLI Uncharacterized MFS-type transporter YfcJ yfcJ b2322 JW2319 yfcJ 40,465 integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_02091, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_02091}. +P0A8W8 YFBU_ECOLI UPF0304 protein YfbU yfbU b2294 JW2291 yfbU 19,536 cellular response to DNA damage stimulus [GO:0006974] cytosol [GO:0005829] cytosol [GO:0005829]; cellular response to DNA damage stimulus [GO:0006974] GO:0005829; GO:0006974 +P64564 YGGT_ECOLI Uncharacterized protein YggT yggT b2952 JW2919 yggT 21,167 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P36928 YEGD_ECOLI Uncharacterized chaperone protein YegD yegD b2069 JW2054 yegD 49,371 cytosol [GO:0005829] cytosol [GO:0005829]; ATP binding [GO:0005524]; ATPase activity [GO:0016887] ATPase activity [GO:0016887]; ATP binding [GO:0005524] GO:0005524; GO:0005829; GO:0016887 +P52123 YFJH_ECOLI Uncharacterized protein YfjH yfjH b2623 JW2603 yfjH 37,139 +P33030 YEIR_ECOLI Zinc-binding GTPase YeiR (EC 3.6.-.-) yeiR b2173 JW2161 yeiR 36,113 GTP binding [GO:0005525]; GTPase activity [GO:0003924]; zinc ion binding [GO:0008270] GTPase activity [GO:0003924]; GTP binding [GO:0005525]; zinc ion binding [GO:0008270] GO:0003924; GO:0005525; GO:0008270 +P75971 YMFH_ECOLI Putative protein YmfH ymfH b1142 JW1128 ymfH 10,963 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P33361 YEHY_ECOLI Glycine betaine uptake system permease protein YehY yehY b2130 JW2118 yehY 41,139 amino acid transport [GO:0006865]; glycine betaine transport [GO:0031460]; transmembrane transport [GO:0055085] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; amino acid transport [GO:0006865]; glycine betaine transport [GO:0031460]; transmembrane transport [GO:0055085] GO:0005886; GO:0006865; GO:0016021; GO:0031460; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +P0AAS5 YLBF_ECOLI Uncharacterized protein YlbF ylbF b0520 JW0509 ylbF 29,597 +P0DPN1 YKIC_ECOLI Protein YkiC ykiC b4731 ykiC 4,432 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. +P0ADM8 YIEE_ECOLI Uncharacterized protein YieE yieE b3712 JW3690 yieE 27,647 lysine biosynthetic process via aminoadipic acid [GO:0019878] cytosol [GO:0005829] cytosol [GO:0005829]; holo-[acyl-carrier-protein] synthase activity [GO:0008897]; magnesium ion binding [GO:0000287]; lysine biosynthetic process via aminoadipic acid [GO:0019878] holo-[acyl-carrier-protein] synthase activity [GO:0008897]; magnesium ion binding [GO:0000287] GO:0000287; GO:0005829; GO:0008897; GO:0019878 +Q2EER5 YMJC_ECOLI Protein YmjC ymjC b4525 JW5960 ymjC 6,725 +P39354 YJHD_ECOLI Putative uncharacterized protein YjhD yjhD b4281 yjhD 8,821 +P37664 YIAC_ECOLI Peptidyl-lysine N-acetyltransferase YiaC (EC 2.3.1.-) (KAT) yiaC b3550 JW3519 yiaC 17,104 internal peptidyl-lysine acetylation [GO:0018393] peptide-lysine-N-acetyltransferase activity [GO:0061733]; internal peptidyl-lysine acetylation [GO:0018393] peptide-lysine-N-acetyltransferase activity [GO:0061733] GO:0018393; GO:0061733 +P64627 YHFL_ECOLI Uncharacterized protein YhfL yhfL b3369 JW3332 yhfL 5,819 integral component of membrane [GO:0016021] integral component of membrane [GO:0016021] GO:0016021 SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Has been predicted to be a lipoprotein, the lipid is predicted to attach to Cys-20 (PubMed:12876315). {ECO:0000305|PubMed:12876315}. +P76269 YEBQ_ECOLI Uncharacterized transporter YebQ yebQ b1828 JW5299 yebQ 48,152 transmembrane transport [GO:0055085] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; transmembrane transport [GO:0055085] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0022857; GO:0055085 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P39409 YJJW_ECOLI Putative glycyl-radical enzyme activating enzyme YjjW (GRE activating enzyme YjjW) (EC 1.97.1.-) yjjW b4379 JW4342 yjjW 31,491 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] 4 iron, 4 sulfur cluster binding [GO:0051539]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491] GO:0016491; GO:0046872; GO:0051539 +P32717 YJCS_ECOLI Putative alkyl/aryl-sulfatase YjcS (EC 3.1.6.-) yjcS b4083 JW5721 yjcS 73,151 dodecyl sulfate metabolic process [GO:0018909] outer membrane-bounded periplasmic space [GO:0030288] outer membrane-bounded periplasmic space [GO:0030288]; alkyl sulfatase activity [GO:0018741]; protein dimerization activity [GO:0046983]; dodecyl sulfate metabolic process [GO:0018909] alkyl sulfatase activity [GO:0018741]; protein dimerization activity [GO:0046983] GO:0018741; GO:0018909; GO:0030288; GO:0046983 +P32109 YIBJ_ECOLI Putative uncharacterized protein YibJ yibJ rhsJ b3595 JW5647 rhsJ yibJ 26,447 +P39279 YJEJ_ECOLI Uncharacterized protein YjeJ yjeJ b4145 JW4105 yjeJ 32,947 +P64612 ZAPE_ECOLI Cell division protein ZapE (Z ring-associated protein ZapE) zapE yhcM b3232 JW3201 yhcM zapE 43,064 cell cycle [GO:0007049]; cell division [GO:0051301] cell division site [GO:0032153]; cytoplasm [GO:0005737] cell division site [GO:0032153]; cytoplasm [GO:0005737]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; cell cycle [GO:0007049]; cell division [GO:0051301] ATPase activity [GO:0016887]; ATP binding [GO:0005524] GO:0005524; GO:0005737; GO:0007049; GO:0016887; GO:0032153; GO:0051301 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01919, ECO:0000269|PubMed:24595368}. Note=Localizes to the constricting Z-ring during late stages of the cell division process. +P33366 YOHD_ECOLI Inner membrane protein YohD yohD b2136 JW2124 yohD 21,445 FtsZ-dependent cytokinesis [GO:0043093] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; FtsZ-dependent cytokinesis [GO:0043093] GO:0005886; GO:0016021; GO:0043093 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P33368 YOHF_ECOLI Uncharacterized oxidoreductase YohF (EC 1.-.-.-) yohF yohE b2137 JW2125 yohE yohF 26,951 oxidoreductase activity [GO:0016491] oxidoreductase activity [GO:0016491] GO:0016491 +P60632 YOHJ_ECOLI UPF0299 membrane protein YohJ yohJ b2141 JW2129 yohJ 14,579 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P67244 YQHA_ECOLI UPF0114 protein YqhA yqhA b3002 JW2971 yqhA 18,641 integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] GO:0005886; GO:0016021 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P0DSG3 YQGH_ECOLI Protein YqgH yqgH b4785 yqgH 3,188 +P0A8W5 YQGE_ECOLI UPF0301 protein YqgE yqgE b2948 JW2915 yqgE 20,686 cytosol [GO:0005829] cytosol [GO:0005829] GO:0005829 +P0DSG9 YRIA_ECOLI Protein YriA yriA b4791 yriA 2,925 +P76561 YPFH_ECOLI Esterase YpfH (EC 3.1.-.-) ypfH b2473 JW5396 ypfH 24,855 carboxylic ester hydrolase activity [GO:0052689]; hydrolase activity, acting on ester bonds [GO:0016788] carboxylic ester hydrolase activity [GO:0052689]; hydrolase activity, acting on ester bonds [GO:0016788] GO:0016788; GO:0052689 +P45394 YRBG_ECOLI Inner membrane protein YrbG yrbG b3196 JW3163 yrbG 34,741 calcium ion transmembrane transport [GO:0070588]; cellular calcium ion homeostasis [GO:0006874] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; calcium ion transmembrane transport [GO:0070588]; cellular calcium ion homeostasis [GO:0006874] calcium, potassium:sodium antiporter activity [GO:0008273]; calcium channel activity [GO:0005262] GO:0005262; GO:0005886; GO:0005887; GO:0006874; GO:0008273; GO:0070588 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P39328 YTFT_ECOLI Galactofuranose transporter permease protein YtfT ytfT b4230 JW5753 ytfT 35,659 carbohydrate transport [GO:0008643] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; transmembrane transporter activity [GO:0022857]; carbohydrate transport [GO:0008643] transmembrane transporter activity [GO:0022857] GO:0005886; GO:0005887; GO:0008643; GO:0016021; GO:0022857 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255}. +Q46942 YQEI_ECOLI Uncharacterized protein YqeI yqeI b2847 JW2815 yqeI 30,850 phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677]; phosphorelay signal transduction system [GO:0000160]; regulation of transcription, DNA-templated [GO:0006355] DNA binding [GO:0003677] GO:0000160; GO:0003677; GO:0006355 +P76092 YNBC_ECOLI Uncharacterized protein YnbC ynbC b1410 JW1407 ynbC 65,456 membrane [GO:0016020] membrane [GO:0016020]; lipase activity [GO:0016298] lipase activity [GO:0016298] GO:0016020; GO:0016298 +P0AE06 ACRA_ECOLI Multidrug efflux pump subunit AcrA (AcrAB-TolC multidrug efflux pump subunit AcrA) (Acridine resistance protein A) acrA lir mtcA b0463 JW0452 lir mtcA acrA 42,197 bile acid and bile salt transport [GO:0015721]; response to antibiotic [GO:0046677]; xenobiotic transport [GO:0042908] efflux pump complex [GO:1990281]; intrinsic component of plasma membrane [GO:0031226]; outer membrane-bounded periplasmic space [GO:0030288] efflux pump complex [GO:1990281]; intrinsic component of plasma membrane [GO:0031226]; outer membrane-bounded periplasmic space [GO:0030288]; identical protein binding [GO:0042802]; xenobiotic transmembrane transporter activity [GO:0042910]; bile acid and bile salt transport [GO:0015721]; response to antibiotic [GO:0046677]; xenobiotic transport [GO:0042908] identical protein binding [GO:0042802]; xenobiotic transmembrane transporter activity [GO:0042910] GO:0015721; GO:0030288; GO:0031226; GO:0042802; GO:0042908; GO:0042910; GO:0046677; GO:1990281 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000269|PubMed:15228545, ECO:0000269|PubMed:16079137}. Note=An unlipidated version of this protein (directed to the periplasm by the OmpA signal sequence) functions normally. +P0A6D0 ARGR_ECOLI Arginine repressor argR xerA b3237 JW3206 xerA argR 16,995 arginine biosynthetic process [GO:0006526]; negative regulation of DNA-templated transcription, initiation [GO:2000143]; plasmid recombination [GO:0042150]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; protein complex oligomerization [GO:0051259]; regulation of arginine biosynthetic process [GO:1900079]; regulation of arginine catabolic process [GO:1900081] cytoplasm [GO:0005737]; transcription regulator complex [GO:0005667] cytoplasm [GO:0005737]; transcription regulator complex [GO:0005667]; arginine binding [GO:0034618]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; arginine biosynthetic process [GO:0006526]; negative regulation of DNA-templated transcription, initiation [GO:2000143]; plasmid recombination [GO:0042150]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; protein complex oligomerization [GO:0051259]; regulation of arginine biosynthetic process [GO:1900079]; regulation of arginine catabolic process [GO:1900081] arginine binding [GO:0034618]; bacterial-type cis-regulatory region sequence-specific DNA binding [GO:0000986]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802] GO:0000986; GO:0003700; GO:0005667; GO:0005737; GO:0006526; GO:0034618; GO:0042150; GO:0042802; GO:0051259; GO:1900079; GO:1900081; GO:2000143; GO:2000144 SUBCELLULAR LOCATION: Cytoplasm. +P25718 AMY1_ECOLI Periplasmic alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase) malS b3571 JW3543 malS 75,713 alpha-glucan catabolic process [GO:0030980]; cellular oligosaccharide catabolic process [GO:0051692] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; alpha-amylase activity [GO:0004556]; alpha-amylase activity (releasing maltohexaose) [GO:0103025]; calcium ion binding [GO:0005509]; alpha-glucan catabolic process [GO:0030980]; cellular oligosaccharide catabolic process [GO:0051692] alpha-amylase activity [GO:0004556]; alpha-amylase activity (releasing maltohexaose) [GO:0103025]; calcium ion binding [GO:0005509] GO:0004556; GO:0005509; GO:0030288; GO:0030980; GO:0042597; GO:0051692; GO:0103025 SUBCELLULAR LOCATION: Periplasm. +P0AA84 CLSB_ECOLI Cardiolipin synthase B (CL synthase) (EC 2.7.8.-) clsB ybhO b0789 JW0772 ybhO clsB 47,634 cardiolipin biosynthetic process [GO:0032049] membrane [GO:0016020]; plasma membrane [GO:0005886] membrane [GO:0016020]; plasma membrane [GO:0005886]; cardiolipin synthase activity [GO:0008808]; phospholipase D activity [GO:0004630]; cardiolipin biosynthetic process [GO:0032049] cardiolipin synthase activity [GO:0008808]; phospholipase D activity [GO:0004630] GO:0004630; GO:0005886; GO:0008808; GO:0016020; GO:0032049 SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:10634942}; Peripheral membrane protein {ECO:0000305|PubMed:10634942}. +P0A9J8 CMPDT_ECOLI Bifunctional chorismate mutase/prephenate dehydratase (Chorismate mutase-prephenate dehydratase) (P-protein) [Includes: Chorismate mutase (CM) (EC 5.4.99.5); Prephenate dehydratase (PDT) (EC 4.2.1.51)] pheA b2599 JW2580 pheA 43,111 chorismate metabolic process [GO:0046417]; L-phenylalanine biosynthetic process [GO:0009094]; tyrosine biosynthetic process [GO:0006571] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; chorismate mutase activity [GO:0004106]; prephenate dehydratase activity [GO:0004664]; chorismate metabolic process [GO:0046417]; L-phenylalanine biosynthetic process [GO:0009094]; tyrosine biosynthetic process [GO:0006571] chorismate mutase activity [GO:0004106]; prephenate dehydratase activity [GO:0004664] GO:0004106; GO:0004664; GO:0005737; GO:0006571; GO:0009094; GO:0046417 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. +P76632 CSE2_ECOLI CRISPR system Cascade subunit CasB casB cse2 ygcK b2759 JW2729 cse2 ygcK casB 18,702 defense response to virus [GO:0051607] protein-containing complex [GO:0032991] protein-containing complex [GO:0032991]; DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723]; defense response to virus [GO:0051607] DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; RNA binding [GO:0003723] GO:0003676; GO:0003677; GO:0003723; GO:0032991; GO:0051607 +P24077 ENTS_ECOLI Enterobactin exporter EntS (Protein p43) entS ybdA b0591 JW0583 ybdA entS 43,282 cellular response to DNA damage stimulus [GO:0006974]; enterobactin transport [GO:0042930]; response to antibiotic [GO:0046677] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; enterobactin transmembrane transporter activity [GO:0042931]; cellular response to DNA damage stimulus [GO:0006974]; enterobactin transport [GO:0042930]; response to antibiotic [GO:0046677] enterobactin transmembrane transporter activity [GO:0042931] GO:0005886; GO:0005887; GO:0006974; GO:0042930; GO:0042931; GO:0046677 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01436, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01436}. +P16676 CYSA_ECOLI Sulfate/thiosulfate import ATP-binding protein CysA (EC 7.3.2.3) (Sulfate-transporting ATPase) cysA b2422 JW2415 cysA 41,059 sulfate transport [GO:0008272] ATP-binding cassette (ABC) transporter complex [GO:0043190] ATP-binding cassette (ABC) transporter complex [GO:0043190]; ABC-type sulfate transporter activity [GO:0015419]; ABC-type thiosulfate transporter activity [GO:0102025]; ATP binding [GO:0005524]; sulfate transport [GO:0008272] ABC-type sulfate transporter activity [GO:0015419]; ABC-type thiosulfate transporter activity [GO:0102025]; ATP binding [GO:0005524] GO:0005524; GO:0008272; GO:0015419; GO:0043190; GO:0102025 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01701}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01701}. +P77214 CUSF_ECOLI Cation efflux system protein CusF cusF cusX ylcC b0573 JW0562 cusX ylcC cusF 12,251 cellular copper ion homeostasis [GO:0006878]; detoxification of copper ion [GO:0010273]; response to copper ion [GO:0046688]; response to silver ion [GO:0010272]; response to zinc ion [GO:0010043] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597] outer membrane-bounded periplasmic space [GO:0030288]; periplasmic space [GO:0042597]; copper chaperone activity [GO:0016531]; copper ion binding [GO:0005507]; metallochaperone activity [GO:0016530]; transition metal ion binding [GO:0046914]; cellular copper ion homeostasis [GO:0006878]; detoxification of copper ion [GO:0010273]; response to copper ion [GO:0046688]; response to silver ion [GO:0010272]; response to zinc ion [GO:0010043] copper chaperone activity [GO:0016531]; copper ion binding [GO:0005507]; metallochaperone activity [GO:0016530]; transition metal ion binding [GO:0046914] GO:0005507; GO:0006878; GO:0010043; GO:0010272; GO:0010273; GO:0016530; GO:0016531; GO:0030288; GO:0042597; GO:0046688; GO:0046914 SUBCELLULAR LOCATION: Periplasm. +P0ABN9 DCUB_ECOLI Anaerobic C4-dicarboxylate transporter DcuB dcuB genF b4123 JW4084 genF dcuB 47,935 C4-dicarboxylate transport [GO:0015740] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; C4-dicarboxylate transmembrane transporter activity [GO:0015556]; succinate:fumarate antiporter activity [GO:0005469]; C4-dicarboxylate transport [GO:0015740] C4-dicarboxylate transmembrane transporter activity [GO:0015556]; succinate:fumarate antiporter activity [GO:0005469] GO:0005469; GO:0005886; GO:0005887; GO:0015556; GO:0015740 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P76330 DGCQ_ECOLI Probable diguanylate cyclase DgcQ (DGC) (EC 2.7.7.65) (Cellulose synthesis regulatory protein) dgcQ yedQ b1956 JW5832 yedQ dgcQ 64,283 cell adhesion involved in single-species biofilm formation [GO:0043709]; cellulose biosynthetic process [GO:0030244]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; cell adhesion involved in single-species biofilm formation [GO:0043709]; cellulose biosynthetic process [GO:0030244]; negative regulation of bacterial-type flagellum-dependent cell motility [GO:1902201] diguanylate cyclase activity [GO:0052621]; GTP binding [GO:0005525]; metal ion binding [GO:0046872] GO:0005525; GO:0005886; GO:0016021; GO:0030244; GO:0043709; GO:0046872; GO:0052621; GO:1902201 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. +P36655 DSBD_ECOLI Thiol:disulfide interchange protein DsbD (EC 1.8.1.8) (C-type cytochrome biogenesis protein CycZ) (Inner membrane copper tolerance protein) (Protein-disulfide reductase) (Disulfide reductase) dsbD cutA2 cycZ dipZ b4136 JW5734 cutA2 cycZ dipZ dsbD 61,795 cell redox homeostasis [GO:0045454]; cytochrome complex assembly [GO:0017004]; response to copper ion [GO:0046688] cytoplasmic side of plasma membrane [GO:0009898]; integral component of plasma membrane [GO:0005887] cytoplasmic side of plasma membrane [GO:0009898]; integral component of plasma membrane [GO:0005887]; electron transfer activity [GO:0009055]; protein disulfide oxidoreductase activity [GO:0015035]; protein-disulfide reductase activity [GO:0047134]; cell redox homeostasis [GO:0045454]; cytochrome complex assembly [GO:0017004]; response to copper ion [GO:0046688] electron transfer activity [GO:0009055]; protein disulfide oxidoreductase activity [GO:0015035]; protein-disulfide reductase activity [GO:0047134] GO:0005887; GO:0009055; GO:0009898; GO:0015035; GO:0017004; GO:0045454; GO:0046688; GO:0047134 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P36837 DTPB_ECOLI Dipeptide and tripeptide permease B dtpB yhiP b3496 JW3463 yhiP dtpB 53,575 dipeptide transmembrane transport [GO:0035442]; protein transport [GO:0015031]; proton transmembrane transport [GO:1902600]; tripeptide transmembrane transport [GO:0035443] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; proton transmembrane transporter activity [GO:0015078]; tripeptide transmembrane transporter activity [GO:0042937]; dipeptide transmembrane transport [GO:0035442]; protein transport [GO:0015031]; proton transmembrane transport [GO:1902600]; tripeptide transmembrane transport [GO:0035443] dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; proton transmembrane transporter activity [GO:0015078]; tripeptide transmembrane transporter activity [GO:0042937] GO:0005886; GO:0005887; GO:0015031; GO:0015078; GO:0015333; GO:0035442; GO:0035443; GO:0042937; GO:0071916; GO:1902600 SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. +P77304 DTPA_ECOLI Dipeptide and tripeptide permease A dtpA tppB ydgR b1634 JW1626 tppB ydgR dtpA 53,991 dipeptide transmembrane transport [GO:0035442]; protein transport [GO:0015031]; proton transmembrane transport [GO:1902600]; tripeptide transmembrane transport [GO:0035443] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886] integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; proton transmembrane transporter activity [GO:0015078]; tripeptide transmembrane transporter activity [GO:0042937]; dipeptide transmembrane transport [GO:0035442]; protein transport [GO:0015031]; proton transmembrane transport [GO:1902600]; tripeptide transmembrane transport [GO:0035443] dipeptide transmembrane transporter activity [GO:0071916]; peptide:proton symporter activity [GO:0015333]; proton transmembrane transporter activity [GO:0015078]; tripeptide transmembrane transporter activity [GO:0042937] GO:0005886; GO:0005887; GO:0015031; GO:0015078; GO:0015333; GO:0035442; GO:0035443; GO:0042937; GO:0071916; GO:1902600 SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. +P27248 GCST_ECOLI Aminomethyltransferase (EC 2.1.2.10) (Glycine cleavage system T protein) gcvT b2905 JW2873 gcvT 40,147 glycine decarboxylation via glycine cleavage system [GO:0019464] cytosol [GO:0005829] cytosol [GO:0005829]; aminomethyltransferase activity [GO:0004047]; transaminase activity [GO:0008483]; glycine decarboxylation via glycine cleavage system [GO:0019464] aminomethyltransferase activity [GO:0004047]; transaminase activity [GO:0008483] GO:0004047; GO:0005829; GO:0008483; GO:0019464 +P0AC88 GM4D_ECOLI GDP-mannose 4,6-dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) gmd yefA yefN b2053 JW2038 yefA yefN gmd 42,047 'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; colanic acid biosynthetic process [GO:0009242]; GDP-mannose metabolic process [GO:0019673] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; GDP-mannose 4,6-dehydratase activity [GO:0008446]; NADP+ binding [GO:0070401]; 'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; colanic acid biosynthetic process [GO:0009242]; GDP-mannose metabolic process [GO:0019673] GDP-mannose 4,6-dehydratase activity [GO:0008446]; NADP+ binding [GO:0070401] GO:0005737; GO:0008446; GO:0009242; GO:0019673; GO:0042351; GO:0070401 +P0A6N8 EFPL_ECOLI Elongation factor P-like protein yeiP b2171 JW5362 yeiP 21,533 cytoplasm [GO:0005737]; cytosol [GO:0005829] cytoplasm [GO:0005737]; cytosol [GO:0005829]; translation elongation factor activity [GO:0003746] translation elongation factor activity [GO:0003746] GO:0003746; GO:0005737; GO:0005829 +A0A7H2C781 A0A7H2C781_ECOLI Protein MgtT mgtT ECK4632 b4775 ECK4632 mgtT 3,858 +A0A7H2C771 A0A7H2C771_ECOLI Protein YadX yadX ECK4622 b4765 ECK4622 yadX 1,806 +A0A7H2C788 A0A7H2C788_ECOLI Protein PssL pssL ECK4639 b4782 ECK4639 pssL 1,604 +A0A7H2C7A6 A0A7H2C7A6_ECOLI Protein YsgD ysgD ECK4656 b4799 ECK4656 ysgD 2,140 +A0A7H2C7A7 A0A7H2C7A7_ECOLI Protein YtgA ytgA ECK4657 b4800 ECK4657 ytgA 1,763 +A0A7H2C7A0 A0A7H2C7A0_ECOLI Putative translational regulatory protein BaxL baxL ECK4651 b4794 ECK4651 baxL 951 +A0A7H2C797 A0A7H2C797_ECOLI Protein YriA yriA ECK4648 b4791 ECK4648 yriA 2,925 +A0A7H2C775 A0A7H2C775_ECOLI Protein YbiE ybiE ECK4626 b4769 ECK4626 ybiE 2,006 +A0A7H2C792 A0A7H2C792_ECOLI Protein YqhJ yqhJ ECK4643 b4786 ECK4643 yqhJ 2,198 +A0A7H2C789 A0A7H2C789_ECOLI Protein YfiS yfiS ECK4639 b4783 ECK4639 yfiS 2,162 +A0A7H2C794 A0A7H2C794_ECOLI Protein YhgO yhgO ECK4645 b4788 ECK4645 yhgO 1,576 +A0A7H2C7A9 A0A7H2C7A9_ECOLI Protein YthB ythB ECK4659 b4802 ECK4659 ythB 3,574 +A0A7H2C773 A0A7H2C773_ECOLI Protein YtiB ytiB ECK4624 b4767 ECK4624 ytiB 2,019 +A0A7H2C777 A0A7H2C777_ECOLI Protein YchT ychT ECK4627 b4771 ECK4627 ychT 1,882 +A0A7H2C780 A0A7H2C780_ECOLI Protein YncP yncP ECK4631 b4774 ECK4631 yncP 2,400 +A0A7H2C778 A0A7H2C778_ECOLI Protein YmiD ymiD ECK4629 b4772 ECK4629 ymiD 4,937 +A0A7H2C799 A0A7H2C799_ECOLI Protein YsaE ysaE ECK4650 b4793 ECK4650 ysaE 2,605 +A0A7H2C776 A0A7H2C776_ECOLI Protein YljB yljB ECK4627 b4770 ECK4627 yljB 2,707 +A0A7H2C7A1 A0A7H2C7A1_ECOLI Protein YibX-S yibX ECK4652 b4795 ECK4652 yibX 2,660 +A0A7H2C798 A0A7H2C798_ECOLI Protein YriB yriB ECK4649 b4792 ECK4649 yriB 1,904 +A0A385XJN2 A0A385XJN2_ECOLI Uncharacterized protein ygiA ECK3027 b3036 ECK3027 ygiA 9,916 +A0A7H2C785 A0A7H2C785_ECOLI Protein YoaM yoaM ECK4636 b4779 ECK4636 yoaM 1,230 +A0A7H2C796 A0A7H2C796_ECOLI Protein YhiY yhiY ECK4647 b4790 ECK4647 yhiY 4,153 +A0A7H2C795 A0A7H2C795_ECOLI Protein YhgP yhgP ECK4646 b4789 ECK4646 yhgP 1,043 +A0A7H2C774 A0A7H2C774_ECOLI Protein YbgV ybgV ECK4625 b4768 ECK4625 ybgV 1,172 +A0A7H2C786 A0A7H2C786_ECOLI Protein YodE yodE ECK4637 b4780 ECK4637 yodE 5,068 +A0A7H2C7A5 A0A7H2C7A5_ECOLI Protein YsdE ysdE ECK4655 b4798 ECK4655 ysdE 2,827 +A0A7H2C7A3 A0A7H2C7A3_ECOLI Protein YibY yibY ECK4653 b4796 ECK4653 yibY 4,027 +A0A7H2C793 A0A7H2C793_ECOLI Protein YqiM yqiM ECK4644 b4787 ECK4644 yqiM 3,305 +A0A7H2C783 A0A7H2C783_ECOLI Protein YdgV ydgV ECK4634 b4777 ECK4634 ydgV 3,906 +A0A7H2C782 A0A7H2C782_ECOLI Qin prophage putative zinc-binding protein YnfU ynfU ECK4633 b4776 ECK4633 ynfU 6,371 +A0A7H2C787 A0A7H2C787_ECOLI Protein EvgL evgL ECK4638 b4781 ECK4638 evgL 1,029 +A0A7H2C784 A0A7H2C784_ECOLI Protein YecV yecV ECK4635 b4778 ECK4635 yecV 1,630 +A0A7H2C7A8 A0A7H2C7A8_ECOLI Protein YkiE ykiE ECK4658 b4801 ECK4658 ykiE 2,720 +A0A7H2C791 A0A7H2C791_ECOLI Protein YqgH yqgH ECK4642 b4785 ECK4642 yqgH 3,188 +A0A7H2C772 A0A7H2C772_ECOLI Putative translational regulatory protein ArgL argL ECK4623 b4766 ECK4623 argL 3,681 +A0A7H2C765 A0A7H2C765_ECOLI Penicillin-binding protein 1B (PBP-1b) (PBP1b) (Murein polymerase) mrcB ECK0148 pbpF ponB b0149 ECK0148 pbpF ponB mrcB 88,890 cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] integral component of membrane [GO:0016021]; peptidoglycan-based cell wall [GO:0009274] integral component of membrane [GO:0016021]; peptidoglycan-based cell wall [GO:0009274]; penicillin binding [GO:0008658]; peptidoglycan glycosyltransferase activity [GO:0008955]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002]; cell wall organization [GO:0071555]; peptidoglycan biosynthetic process [GO:0009252]; regulation of cell shape [GO:0008360]; response to antibiotic [GO:0046677] penicillin binding [GO:0008658]; peptidoglycan glycosyltransferase activity [GO:0008955]; serine-type D-Ala-D-Ala carboxypeptidase activity [GO:0009002] GO:0008360; GO:0008658; GO:0008955; GO:0009002; GO:0009252; GO:0009274; GO:0016021; GO:0046677; GO:0071555 +A0A7H2C7A2 A0A7H2C7A2_ECOLI Protein YibX yibX ECK4652 b4795 ECK4652 yibX 8,757 +A0A7H2C7B0 A0A7H2C7B0_ECOLI Leader peptide SpeFL (Arrest peptide SpeFL) speFL ECK4660 b4803 ECK4660 speFL 4,249 regulation of translational elongation [GO:0006448]; transcriptional attenuation by ribosome [GO:0031556] rRNA binding [GO:0019843]; regulation of translational elongation [GO:0006448]; transcriptional attenuation by ribosome [GO:0031556] rRNA binding [GO:0019843] GO:0006448; GO:0019843; GO:0031556 +A0A7H2C769 A0A7H2C769_ECOLI Putative type II secretion system C-type protein YghF yghF ecfA ECK2965 b2970 ecfA ECK2965 yghF 37,349 protein secretion by the type II secretion system [GO:0015628] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627] integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627]; protein secretion by the type II secretion system [GO:0015628] GO:0005886; GO:0015627; GO:0015628; GO:0016021 +A0A7H2C768 A0A7H2C768_ECOLI Putative type II secretion system L-type protein YghE yghE ecfB ECK2964 b2969 ecfB ECK2964 yghE 32,058 protein secretion by the type II secretion system [GO:0015628] Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627] Gram-negative-bacterium-type cell wall [GO:0009276]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; type II protein secretion system complex [GO:0015627]; protein secretion by the type II secretion system [GO:0015628] GO:0005886; GO:0009276; GO:0015627; GO:0015628; GO:0016021 +A0A7H2C7A4 A0A7H2C7A4_ECOLI Protein YicU yicU ECK4654 b4797 ECK4654 yicU 2,183 +A0A7H2C779 A0A7H2C779_ECOLI Protein YnaN ynaN ECK4630 b4773 ECK4630 ynaN 1,992 +A0A7H2C770 A0A7H2C770_ECOLI McrBS mcrB ECK4336 rglB b4346 ECK4336 rglB mcrB 34,660 ATP binding [GO:0005524]; ATPase activity [GO:0016887] ATPase activity [GO:0016887]; ATP binding [GO:0005524] GO:0005524; GO:0016887 +A0A7H2C766 A0A7H2C766_ECOLI NAD-dependent protein deacylase (EC 2.3.1.286) (Regulatory protein SIR2 homolog) cobB ECK1106 ycfY b1120 ECK1106 ycfY cobB 26,716 cytoplasm [GO:0005737] cytoplasm [GO:0005737]; NAD+ binding [GO:0070403]; NAD-dependent protein deacetylase activity [GO:0034979]; protein-malonyllysine demalonylase activity [GO:0036054]; protein-succinyllysine desuccinylase activity [GO:0036055]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270] NAD+ binding [GO:0070403]; NAD-dependent protein deacetylase activity [GO:0034979]; protein-malonyllysine demalonylase activity [GO:0036054]; protein-succinyllysine desuccinylase activity [GO:0036055]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270] GO:0005737; GO:0008270; GO:0016740; GO:0034979; GO:0036054; GO:0036055; GO:0070403 SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01121}. +A0A385XK32 A0A385XK32_ECOLI Putative YjfA yzfA ECK4219 ileR yjfA b4223 ECK4219 ileR yjfA yzfA 10,585 +A0A7H2C790 A0A7H2C790_ECOLI Protein YqgG yqgG ECK4641 b4784 ECK4641 yqgG 5,220 +A0A7H2C767 A0A7H2C767_ECOLI Chaperone protein ClpB clpB ECK2590 htpM b2592 ECK2590 htpM clpB 79,870 protein refolding [GO:0042026]; response to heat [GO:0009408] cytoplasm [GO:0005737] cytoplasm [GO:0005737]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; protein refolding [GO:0042026]; response to heat [GO:0009408] ATPase activity [GO:0016887]; ATP binding [GO:0005524] GO:0005524; GO:0005737; GO:0009408; GO:0016887; GO:0042026 diff --git a/data/ecoli_annotation_description.txt b/data/ecoli_annotation_description.txt new file mode 100644 index 0000000..f635448 --- /dev/null +++ b/data/ecoli_annotation_description.txt @@ -0,0 +1,9 @@ +Proteome annotation of Escherichia coli (strain K12). + +Information taken from https://www.uniprot.org/proteomes/UP000000625 +Last modified March 7, 2021 + +"The complete genome sequence of Escherichia coli K-12." +Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. +Science 277:1453-1462(1997) +