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homepage		The Molecular Biophysics of Evolutionary and Physiological Adaptation	Griffin Chure | Ph.D. Thesis	title title_url description Summary # The ability to adapt is central to the definition of 'Life'. Adaptation can be found across the biological scales, governing the nanosecond-scale conformational switching of proteins to ecological dynamics. This website presents the text of my Ph.D. thesis in which I dissected adaptive processes at the molecular and organismal level. All research, unless otherwise stated, was performed at the California Institute of Technology under the guidance of <a href="http://rpgroup.caltech.edu/">Rob Phillips</a>.	title excerpt cta url Acknowledgements On the shoulders of giants. read acknowledgements title excerpt cta url Abstract The scope of adaptation in transcriptional regulation read abstract title excerpt cta url Chapter I: Introduction The ubiquity of adaptive behavior in biological matter. read chapter_01 title excerpt cta url Chapter II: Molecular Adaptation Signal processing within allosteric molecules read chapter_02 title excerpt cta url Chapter III: Evolutionary Adaptation Using the simple repression state variable to predict mutant phenotypes read chapter_03 title excerpt cta url Chapter IV: Physiological Adaptation On the physiological adaptability of a simple genetic circuit read chapter_04 title excerpt cta url Chapter V: Survival Adaptation where it counts: surviving environmental insults. read chapter_05 title excerpt cta url Chapter VI: Supplement to Chapter II Supplemental information and extended methods for Chapter II read chapter_06 title excerpt cta url Chapter VII: Supplement to Chapter III Supplemental information and extended methods for Chapter III read chapter_07 title excerpt cta url Chapter VIII: Supplement to Chapter IV Supplemental information and extended methods for Chapter IV read chapter_08 title excerpt cta url Chapter IX: Supplement to Chapter V Supplemental information and extended methods for Chapter V read chapter_09