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Update create-reference-panels.md
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lukfor authored Feb 26, 2020
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A legend file is a tab-delimited file consisting of 5 columns (`id`, `position`, `a0`, `a1`, `population.aaf`). It is used by Michigan Imputation Server to create QC Statistics.
`a0` and `a1` including the ref/alt alleles, `population.aaf` the alternate allele frequency.
Please note that `population` must be substituted by the actual population (e.g. eur). This population is then specified in the [minimac4.yaml file](https://github.com/genepi/imputationserver/blob/master/files/minimac4.yaml).
Please note that `population` must be substituted by the actual population (e.g. eur).
A legend file for chr20 can be found [here](https://github.com/genepi/imputationserver/blob/master/test-data/configs/hapmap-chr20/ref-panels/hapmap_r22.chr20.CEU.hg19_impute.legend.gz?raw=true).

Please execute the following commands (starting from vcf files) to create the legend files:
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