diff --git a/src/gleam/regex.gleam b/src/gleam/regex.gleam
index d1f8ef0a..a849ed68 100644
--- a/src/gleam/regex.gleam
+++ b/src/gleam/regex.gleam
@@ -214,3 +214,27 @@ pub fn replace(
   in string: String,
   with substitute: String,
 ) -> String
+
+/// Creates a new `String` by replacing the first substring that matches the regular
+/// expression.
+///
+/// ## Examples
+///
+/// ```gleam
+/// let assert Ok(re) = regex.from_string("^https://")
+/// replace_first(one_of: re, in: "https://example.com", with: "www.")
+/// // -> "www.example.com"
+/// ```
+///
+/// ```gleam
+/// let assert Ok(re) = regex.from_string("[, +-]")
+/// replace_first(one_of: re, in: "a,b-c d+e", with: "/")
+/// // -> "a/b-c d+e"
+/// ```
+@external(erlang, "gleam_stdlib", "regex_replace_first")
+@external(javascript, "../gleam_stdlib.mjs", "regex_replace_first")
+pub fn replace_first(
+  one_of pattern: Regex,
+  in string: String,
+  with substitute: String,
+) -> String
diff --git a/src/gleam/string.gleam b/src/gleam/string.gleam
index e530c8fa..e6d69f5e 100644
--- a/src/gleam/string.gleam
+++ b/src/gleam/string.gleam
@@ -103,6 +103,31 @@ pub fn replace(
   |> string_builder.to_string
 }
 
+/// Creates a new `String` by replacing the first occurrence of a given substring.
+///
+/// ## Examples
+///
+/// ```gleam
+/// replace_first("www.example.com", each: ".", with: "-")
+/// // -> "www-example.com"
+/// ```
+///
+/// ```gleam
+/// replace_first("a,b,c,d,e", each: ",", with: "/")
+/// // -> "a/b,c,d,e"
+/// ```
+///
+pub fn replace_first(
+  in string: String,
+  one_of pattern: String,
+  with substitute: String,
+) -> String {
+  string
+  |> string_builder.from_string
+  |> string_builder.replace_first(one_of: pattern, with: substitute)
+  |> string_builder.to_string
+}
+
 /// Creates a new `String` with all the graphemes in the input `String` converted to
 /// lowercase.
 ///
diff --git a/src/gleam/string_builder.gleam b/src/gleam/string_builder.gleam
index 24445a20..8c538f2f 100644
--- a/src/gleam/string_builder.gleam
+++ b/src/gleam/string_builder.gleam
@@ -205,6 +205,16 @@ pub fn replace(
   with substitute: String,
 ) -> StringBuilder
 
+/// Replaces the first instance of a pattern with a given string substitute.
+///
+@external(erlang, "gleam_stdlib", "string_replace_first")
+@external(javascript, "../gleam_stdlib.mjs", "string_replace_first")
+pub fn replace_first(
+  in builder: StringBuilder,
+  one_of pattern: String,
+  with substitute: String,
+) -> StringBuilder
+
 /// Compares two builders to determine if they have the same textual content.
 ///
 /// Comparing two iodata using the `==` operator may return `False` even if they
diff --git a/src/gleam_stdlib.erl b/src/gleam_stdlib.erl
index 1fc15b2d..df33c7cf 100644
--- a/src/gleam_stdlib.erl
+++ b/src/gleam_stdlib.erl
@@ -14,7 +14,8 @@
     decode_tuple5/1, decode_tuple6/1, tuple_get/2, classify_dynamic/1, print/1,
     println/1, print_error/1, println_error/1, inspect/1, float_to_string/1,
     int_from_base_string/2, utf_codepoint_list_to_string/1, contains_string/2,
-    crop_string/2, base16_decode/1, string_replace/3, regex_replace/3, slice/3, bit_array_to_int_and_size/1
+    crop_string/2, base16_decode/1, string_replace/3, regex_replace/3, slice/3,
+    bit_array_to_int_and_size/1, string_replace_first/3, regex_replace_first/3
 ]).
 
 %% Taken from OTP's uri_string module
@@ -266,6 +267,9 @@ regex_scan(Regex, String) ->
 regex_replace(Regex, Subject, Replacement) ->
     re:replace(Subject, Regex, Replacement, [global, {return, binary}]).
 
+regex_replace_first(Regex, Subject, Replacement) ->
+    re:replace(Subject, Regex, Replacement, [{return, binary}]).
+
 base_decode64(S) ->
     try {ok, base64:decode(S)}
     catch error:_ -> {error, nil}
@@ -553,6 +557,9 @@ base16_decode(String) ->
 string_replace(String, Pattern, Replacement) ->
     string:replace(String, Pattern, Replacement, all).
 
+string_replace_first(String, Pattern, Replacement) ->
+    string:replace(String, Pattern, Replacement).
+
 slice(String, Index, Length) ->
     case string:slice(String, Index, Length) of
         X when is_binary(X) -> X;
diff --git a/src/gleam_stdlib.mjs b/src/gleam_stdlib.mjs
index 50ebb46f..0ee2370e 100644
--- a/src/gleam_stdlib.mjs
+++ b/src/gleam_stdlib.mjs
@@ -127,6 +127,10 @@ export function string_replace(string, target, substitute) {
   );
 }
 
+export function string_replace_first(string, target, substitute) {
+  return string.replace(target, substitute);
+}
+
 export function string_reverse(string) {
   return [...string].reverse().join("");
 }
@@ -451,6 +455,13 @@ export function regex_replace(regex, original_string, replacement) {
   return original_string.replaceAll(regex, replacement);
 }
 
+export function regex_replace_first(regex, original_string, replacement) {
+  // Forcibly strip the g flag from the regex, if it's present
+  let flags = regex.toString().split("/").pop().replace("g", "");
+  let match = new RegExp(regex, flags);
+  return original_string.replace(match, replacement);
+}
+
 export function new_map() {
   return Dict.new();
 }
diff --git a/test/gleam/regex_test.gleam b/test/gleam/regex_test.gleam
index e5175779..136ecd3d 100644
--- a/test/gleam/regex_test.gleam
+++ b/test/gleam/regex_test.gleam
@@ -185,3 +185,15 @@ pub fn replace_3_test() {
   regex.replace(re, "🐈🐈 are great!", "🐕")
   |> should.equal("🐕🐕 are great!")
 }
+
+pub fn replace_first_test() {
+  let assert Ok(re) = regex.from_string("🐈")
+  regex.replace_first(in: "🐈🐈 are great!", one_of: re, with: "🐕")
+  |> should.equal("🐕🐈 are great!")
+}
+
+pub fn replace_first_of_many_test() {
+  let assert Ok(re) = regex.from_string("[, +-]")
+  regex.replace_first(one_of: re, in: "a,b-c d+e", with: "/")
+  |> should.equal("a/b-c d+e")
+}
diff --git a/test/gleam/string_test.gleam b/test/gleam/string_test.gleam
index 6d3031e4..ac311fee 100644
--- a/test/gleam/string_test.gleam
+++ b/test/gleam/string_test.gleam
@@ -92,6 +92,22 @@ pub fn replace_test() {
   |> should.equal("Gleam++Erlang++Elixir")
 }
 
+pub fn replace_first_0_test() {
+  "Gleam,Erlang,Elixir"
+  |> string.replace_first(",", "++")
+  |> should.equal("Gleam++Erlang,Elixir")
+}
+
+pub fn replace_first_1_test() {
+  string.replace_first(in: "🐈🐈 are great!", one_of: "🐈", with: "🐕")
+  |> should.equal("🐕🐈 are great!")
+}
+
+pub fn replace_first_2_test() {
+  string.replace_first(one_of: ",", in: "a,b,c,d,e", with: "/")
+  |> should.equal("a/b,c,d,e")
+}
+
 pub fn append_test() {
   "Test"
   |> string.append(" Me")