diff --git a/GF_glyphsets/Latin/glyphs/CustomFilter_GF_Latin.plist b/GF_glyphsets/Latin/glyphs/CustomFilter_GF_Latin.plist
index d829c0f2ec..e6b70cd089 100644
--- a/GF_glyphsets/Latin/glyphs/CustomFilter_GF_Latin.plist
+++ b/GF_glyphsets/Latin/glyphs/CustomFilter_GF_Latin.plist
@@ -782,8 +782,6 @@
 			<string>gcommaaccent</string>
 			<string>Hbar</string>
 			<string>hbar</string>
-			<string>Itilde</string>
-			<string>itilde</string>
 			<string>Imacron</string>
 			<string>imacron</string>
 			<string>Iogonek</string>
@@ -822,8 +820,6 @@
 			<string>scaron</string>
 			<string>Tcaron</string>
 			<string>tcaron</string>
-			<string>Utilde</string>
-			<string>utilde</string>
 			<string>Umacron</string>
 			<string>umacron</string>
 			<string>Uring</string>
@@ -848,7 +844,6 @@
 			<string>Tcommaaccent</string>
 			<string>tcommaaccent</string>
 			<string>jdotless</string>
-			<string>apostrophemod</string>
 			<string>circumflex</string>
 			<string>caron</string>
 			<string>breve</string>
@@ -878,12 +873,8 @@
 			<string>Wdieresis</string>
 			<string>wdieresis</string>
 			<string>Germandbls</string>
-			<string>Etilde</string>
-			<string>etilde</string>
 			<string>Ygrave</string>
 			<string>ygrave</string>
-			<string>Ytilde</string>
-			<string>ytilde</string>
 			<string>endash</string>
 			<string>emdash</string>
 			<string>quoteleft</string>
diff --git a/GF_glyphsets/Latin/glyphs/GF_Latin_Core.glyphs b/GF_glyphsets/Latin/glyphs/GF_Latin_Core.glyphs
index 439cc93ecb..9f0c45ca4d 100644
--- a/GF_glyphsets/Latin/glyphs/GF_Latin_Core.glyphs
+++ b/GF_glyphsets/Latin/glyphs/GF_Latin_Core.glyphs
@@ -489,10 +489,6 @@ glyphname = cedilla;
 unicode = 184;
 },
 {
-glyphname = apostrophemod;
-unicode = 700;
-},
-{
 glyphname = circumflex;
 unicode = 710;
 },
@@ -1183,14 +1179,6 @@ glyphname = hbar;
 unicode = 295;
 },
 {
-glyphname = Itilde;
-unicode = 296;
-},
-{
-glyphname = itilde;
-unicode = 297;
-},
-{
 glyphname = Imacron;
 unicode = 298;
 },
@@ -1343,14 +1331,6 @@ glyphname = tcaron;
 unicode = 357;
 },
 {
-glyphname = Utilde;
-unicode = 360;
-},
-{
-glyphname = utilde;
-unicode = 361;
-},
-{
 glyphname = Umacron;
 unicode = 362;
 },
@@ -1475,28 +1455,12 @@ glyphname = Germandbls;
 unicode = 7838;
 },
 {
-glyphname = Etilde;
-unicode = 7868;
-},
-{
-glyphname = etilde;
-unicode = 7869;
-},
-{
 glyphname = Ygrave;
 unicode = 7922;
 },
 {
 glyphname = ygrave;
 unicode = 7923;
-},
-{
-glyphname = Ytilde;
-unicode = 7928;
-},
-{
-glyphname = ytilde;
-unicode = 7929;
 }
 );
 instances = (
diff --git a/GF_glyphsets/Latin/nam/GF_Latin_Core.nam b/GF_glyphsets/Latin/nam/GF_Latin_Core.nam
index 6469ffad1c..370726ea0d 100644
--- a/GF_glyphsets/Latin/nam/GF_Latin_Core.nam
+++ b/GF_glyphsets/Latin/nam/GF_Latin_Core.nam
@@ -210,8 +210,6 @@
 0x0123 LATIN SMALL LETTER G WITH CEDILLA
 0x0126 LATIN CAPITAL LETTER H WITH STROKE
 0x0127 LATIN SMALL LETTER H WITH STROKE
-0x0128 LATIN CAPITAL LETTER I WITH TILDE
-0x0129 LATIN SMALL LETTER I WITH TILDE
 0x012A LATIN CAPITAL LETTER I WITH MACRON
 0x012B LATIN SMALL LETTER I WITH MACRON
 0x012E LATIN CAPITAL LETTER I WITH OGONEK
@@ -250,8 +248,6 @@
 0x0161 LATIN SMALL LETTER S WITH CARON
 0x0164 LATIN CAPITAL LETTER T WITH CARON
 0x0165 LATIN SMALL LETTER T WITH CARON
-0x0168 LATIN CAPITAL LETTER U WITH TILDE
-0x0169 LATIN SMALL LETTER U WITH TILDE
 0x016A LATIN CAPITAL LETTER U WITH MACRON
 0x016B LATIN SMALL LETTER U WITH MACRON
 0x016E LATIN CAPITAL LETTER U WITH RING ABOVE
@@ -276,7 +272,6 @@
 0x021A LATIN CAPITAL LETTER T WITH COMMA BELOW
 0x021B LATIN SMALL LETTER T WITH COMMA BELOW
 0x0237 LATIN SMALL LETTER DOTLESS J
-0x02BC MODIFIER LETTER APOSTROPHE
 0x02C6 MODIFIER LETTER CIRCUMFLEX ACCENT
 0x02C7 CARON
 0x02D8 BREVE
@@ -306,12 +301,8 @@
 0x1E84 LATIN CAPITAL LETTER W WITH DIAERESIS
 0x1E85 LATIN SMALL LETTER W WITH DIAERESIS
 0x1E9E LATIN CAPITAL LETTER SHARP S
-0x1EBC LATIN CAPITAL LETTER E WITH TILDE
-0x1EBD LATIN SMALL LETTER E WITH TILDE
 0x1EF2 LATIN CAPITAL LETTER Y WITH GRAVE
 0x1EF3 LATIN SMALL LETTER Y WITH GRAVE
-0x1EF8 LATIN CAPITAL LETTER Y WITH TILDE
-0x1EF9 LATIN SMALL LETTER Y WITH TILDE
 0x2013 EN DASH
 0x2014 EM DASH
 0x2018 LEFT SINGLE QUOTATION MARK
diff --git a/GF_glyphsets/Latin/txt/nice-names/GF_Latin_Core.txt b/GF_glyphsets/Latin/txt/nice-names/GF_Latin_Core.txt
index 8b5c695635..1824f0fbab 100644
--- a/GF_glyphsets/Latin/txt/nice-names/GF_Latin_Core.txt
+++ b/GF_glyphsets/Latin/txt/nice-names/GF_Latin_Core.txt
@@ -210,8 +210,6 @@ Gcommaaccent
 gcommaaccent
 Hbar
 hbar
-Itilde
-itilde
 Imacron
 imacron
 Iogonek
@@ -250,8 +248,6 @@ Scaron
 scaron
 Tcaron
 tcaron
-Utilde
-utilde
 Umacron
 umacron
 Uring
@@ -276,7 +272,6 @@ scommaaccent
 Tcommaaccent
 tcommaaccent
 jdotless
-apostrophemod
 circumflex
 caron
 breve
@@ -306,12 +301,8 @@ wacute
 Wdieresis
 wdieresis
 Germandbls
-Etilde
-etilde
 Ygrave
 ygrave
-Ytilde
-ytilde
 endash
 emdash
 quoteleft
diff --git a/GF_glyphsets/Latin/txt/prod-names/GF_Latin_Core.txt b/GF_glyphsets/Latin/txt/prod-names/GF_Latin_Core.txt
index 7e237a5c5c..caffad45db 100644
--- a/GF_glyphsets/Latin/txt/prod-names/GF_Latin_Core.txt
+++ b/GF_glyphsets/Latin/txt/prod-names/GF_Latin_Core.txt
@@ -210,8 +210,6 @@ uni0122
 uni0123
 Hbar
 hbar
-Itilde
-itilde
 Imacron
 imacron
 Iogonek
@@ -250,8 +248,6 @@ Scaron
 scaron
 Tcaron
 tcaron
-Utilde
-utilde
 Umacron
 umacron
 Uring
@@ -276,7 +272,6 @@ uni0219
 uni021A
 uni021B
 uni0237
-uni02BC
 circumflex
 caron
 breve
@@ -306,12 +301,8 @@ wacute
 Wdieresis
 wdieresis
 uni1E9E
-uni1EBC
-uni1EBD
 Ygrave
 ygrave
-uni1EF8
-uni1EF9
 endash
 emdash
 quoteleft
diff --git a/Lib/glyphsets/definitions/__init__.py b/Lib/glyphsets/definitions/__init__.py
index 801bc7dcaa..91af464154 100644
--- a/Lib/glyphsets/definitions/__init__.py
+++ b/Lib/glyphsets/definitions/__init__.py
@@ -18,7 +18,6 @@
             "es_Latn",  # Spanish
             "fi_Latn",  # Finnish
             "fr_Latn",  # French
-            "gn_Latn",  # Guarani
             "hr_Latn",  # Croatian
             "hu_Latn",  # Hungarian
             "is_Latn",  # Icelandic
@@ -30,7 +29,6 @@
             "nl_Latn",  # Dutch
             "pl_Latn",  # Polish
             "pt_Latn",  # Portuguese
-            "qu_Latn",  # Quechua
             "ro_Latn",  # Romanian
             "sk_Latn",  # Slovak
             "sq_Latn",  # Albanian
diff --git a/Lib/glyphsets/definitions/nam/GF_Latin_Core.nam b/Lib/glyphsets/definitions/nam/GF_Latin_Core.nam
index 6469ffad1c..370726ea0d 100644
--- a/Lib/glyphsets/definitions/nam/GF_Latin_Core.nam
+++ b/Lib/glyphsets/definitions/nam/GF_Latin_Core.nam
@@ -210,8 +210,6 @@
 0x0123 LATIN SMALL LETTER G WITH CEDILLA
 0x0126 LATIN CAPITAL LETTER H WITH STROKE
 0x0127 LATIN SMALL LETTER H WITH STROKE
-0x0128 LATIN CAPITAL LETTER I WITH TILDE
-0x0129 LATIN SMALL LETTER I WITH TILDE
 0x012A LATIN CAPITAL LETTER I WITH MACRON
 0x012B LATIN SMALL LETTER I WITH MACRON
 0x012E LATIN CAPITAL LETTER I WITH OGONEK
@@ -250,8 +248,6 @@
 0x0161 LATIN SMALL LETTER S WITH CARON
 0x0164 LATIN CAPITAL LETTER T WITH CARON
 0x0165 LATIN SMALL LETTER T WITH CARON
-0x0168 LATIN CAPITAL LETTER U WITH TILDE
-0x0169 LATIN SMALL LETTER U WITH TILDE
 0x016A LATIN CAPITAL LETTER U WITH MACRON
 0x016B LATIN SMALL LETTER U WITH MACRON
 0x016E LATIN CAPITAL LETTER U WITH RING ABOVE
@@ -276,7 +272,6 @@
 0x021A LATIN CAPITAL LETTER T WITH COMMA BELOW
 0x021B LATIN SMALL LETTER T WITH COMMA BELOW
 0x0237 LATIN SMALL LETTER DOTLESS J
-0x02BC MODIFIER LETTER APOSTROPHE
 0x02C6 MODIFIER LETTER CIRCUMFLEX ACCENT
 0x02C7 CARON
 0x02D8 BREVE
@@ -306,12 +301,8 @@
 0x1E84 LATIN CAPITAL LETTER W WITH DIAERESIS
 0x1E85 LATIN SMALL LETTER W WITH DIAERESIS
 0x1E9E LATIN CAPITAL LETTER SHARP S
-0x1EBC LATIN CAPITAL LETTER E WITH TILDE
-0x1EBD LATIN SMALL LETTER E WITH TILDE
 0x1EF2 LATIN CAPITAL LETTER Y WITH GRAVE
 0x1EF3 LATIN SMALL LETTER Y WITH GRAVE
-0x1EF8 LATIN CAPITAL LETTER Y WITH TILDE
-0x1EF9 LATIN SMALL LETTER Y WITH TILDE
 0x2013 EN DASH
 0x2014 EM DASH
 0x2018 LEFT SINGLE QUOTATION MARK