diff --git a/.github/workflows/unittests.yml b/.github/workflows/unittests.yml
index 860fdfc..5b02f9d 100644
--- a/.github/workflows/unittests.yml
+++ b/.github/workflows/unittests.yml
@@ -4,39 +4,29 @@ on: push
 
 jobs:
   build:
-    runs-on: ${{ matrix.platform }}
-    strategy:
-      matrix:
-        platform: [ubuntu-latest]
-        python-version: ["3.10.9"]
+    runs-on: ubuntu-latest
 
     steps:
-      - uses: actions/checkout@v2
+      - uses: actions/checkout@v3
         with:
           submodules: recursive
 
-      - name: Set up Python ${{ matrix.python-version }}
-        uses: actions/setup-python@v2.2.2
+      - uses: actions/setup-python@v4
         with:
-          python-version: ${{ matrix.python-version }}
+          python-version: "3.11"
 
-      - name: Install dependencies
-        run: |
-          pip install -r requirements.txt coverage
+      - uses: snok/install-poetry@v1
+        with:
+          version: 1.3.2
+          virtualenvs-create: true
+          virtualenvs-in-project: true
+
+      - run: poetry install --no-interaction --no-root
 
-      - name: Test
-        run: |
-          coverage run -m unittest
-          coverage xml
+      - run: poetry run pytest --cov --cov-report xml:coverage.xml --cov-append -vv --hypothesis-show-statistics
 
       - name: Run codacy-coverage-reporter
         uses: codacy/codacy-coverage-reporter-action@v1
         with:
           project-token: ${{ secrets.CODACY_PROJECT_TOKEN }}
-          coverage-reports: coverage.xml
-
-      - uses: codecov/codecov-action@v3
-        with:
-          fail_ci_if_error: false
-          token: ${{ secrets.CODECOV_TOKEN }}
-          files: ./coverage.xml
+          coverage-reports: coverage.xml
\ No newline at end of file
diff --git a/.gitignore b/.gitignore
index 4950e79..cdf1b75 100644
--- a/.gitignore
+++ b/.gitignore
@@ -49,3 +49,8 @@ coverage.xml
 *.cover
 .hypothesis/
 .pytest_cache/
+
+
+.venv
+.vscode
+poetry.lock
\ No newline at end of file
diff --git a/Dockerfile b/Dockerfile
index 5946ea4..c4742b5 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -1,5 +1,5 @@
 #==============================================================================================
-FROM python:3.10
+FROM python:3.11
 WORKDIR /opt/software
 COPY . .
 RUN pip install .
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000..7f7790d
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,34 @@
+[tool.poetry]
+name = "prodigy-lig"
+version = "1.1.0"
+description = "Calculate protein-small molecule binding affinities."
+authors = ["BonvinLab <bonvinlab.support@uu.nl>"]
+license = "Apache-2.0"
+readme = "README.md"
+classifiers = [
+  "Development Status :: 5 - Production/Stable",
+  "License :: OSI Approved :: Apache Software License",
+  "Programming Language :: Python :: 3.11",
+  "Topic :: Scientific/Engineering :: Chemistry",
+  "Topic :: Scientific/Engineering :: Bio-Informatics",
+  "Intended Audience :: Science/Research",
+]
+packages = [{ include = "prodigy_lig" }]
+
+[tool.poetry.dependencies]
+python = "^3.11"
+numpy = "^1.26.4"
+biopython = "^1.79"
+
+[tool.poetry.group.dev.dependencies]
+pytest = "^8.1.1"
+coverage = "^7.5.0"
+pytest-cov = "^5.0.0"
+hypothesis = "^6.100.1"
+
+[tool.poetry.scripts]
+prodigy_lig = "prodigy_lig.prodigy_lig:main"
+
+[build-system]
+requires = ["poetry-core"]
+build-backend = "poetry.core.masonry.api"
diff --git a/setup.py b/setup.py
deleted file mode 100644
index bc6726e..0000000
--- a/setup.py
+++ /dev/null
@@ -1,34 +0,0 @@
-import os
-from setuptools import setup
-import codecs
-
-from prodigy_lig import version
-
-
-def read(fname):
-    return codecs.open(os.path.join(os.path.dirname(__file__), fname), encoding='utf-8').read()
-
-with open("requirements.txt") as f:
-    required = f.read().splitlines()
-
-setup(
-    name='prodigy_lig',
-    version = version,
-    description=("Calculate protein-small molecule binding affinities."),
-    url='http://github.com/haddocking/prodigy-lig',
-    author='Computational Structural Biology Group @ Utrecht University',
-    author_email='prodigy.bonvinlab@gmail.com',
-    license='Apache 2.0',
-    packages=['prodigy_lig'],
-    long_description=read('README.md'),
-    classifiers=[
-        "Development Status :: 4 - Beta",
-    ],
-    install_requires=required,
-    entry_points={
-        'console_scripts': [
-            'prodigy_lig = prodigy_lig.prodigy_lig:main',
-        ]
-    },
-    zip_safe=False
-)