diff --git a/Base/Python/slicer/util.py b/Base/Python/slicer/util.py
index 8199164f0c9..6e4c482eddd 100644
--- a/Base/Python/slicer/util.py
+++ b/Base/Python/slicer/util.py
@@ -2850,7 +2850,10 @@ def tempDirectory(key="__SlicerTemp__", tempDir=None, includeDateTime=True):
     if not tempDir:
         tempDir = qt.QDir(slicer.app.temporaryPath)
     if includeDateTime:
-        tempDirName = key + qt.QDateTime().currentDateTime().toString("yyyy-MM-dd_hh+mm+ss.zzz")
+        # Force using en-US locale, otherwise for example on a computer with
+        # Egyptian Arabic (ar-EG) locale, Arabic numerals may be used.
+        enUsLocale = qt.QLocale(qt.QLocale.English, qt.QLocale.UnitedStates)
+        tempDirName = key + enUsLocale.toString(qt.QDateTime.currentDateTime(), "yyyy-MM-dd_hh+mm+ss.zzz")
     else:
         tempDirName = key
     fileInfo = qt.QFileInfo(qt.QDir(tempDir), tempDirName)
diff --git a/Base/QTGUI/qSlicerApplication.cxx b/Base/QTGUI/qSlicerApplication.cxx
index 369a968e160..1cd1a036d90 100644
--- a/Base/QTGUI/qSlicerApplication.cxx
+++ b/Base/QTGUI/qSlicerApplication.cxx
@@ -1017,12 +1017,15 @@ void qSlicerApplication::setupFileLogging()
 
   // Add new log file path for the current session
   QString tempDir = this->temporaryPath();
+  // Force using en-US locale, otherwise for example on a computer with
+  // Egyptian Arabic (ar-EG) locale, Arabic numerals may be used.
+  QLocale enUsLocale = QLocale(QLocale::English, QLocale::UnitedStates);
   QString currentLogFilePath = QString("%1/%2_%3_%4_%5_%6.log")
     .arg(tempDir)
     .arg(this->applicationName())
     .arg(qSlicerApplication::application()->applicationVersion())
     .arg(qSlicerApplication::application()->mainApplicationRevision())
-    .arg(QDateTime::currentDateTime().toString("yyyyMMdd_hhmmss"))
+    .arg(enUsLocale.toString(QDateTime::currentDateTime(), "yyyyMMdd_hhmmss"))
     .arg(QRandomGenerator::global()->generate() % 1000, 3, 10, QLatin1Char('0'));
   logFilePaths.prepend(currentLogFilePath);
 
@@ -1117,9 +1120,12 @@ void qSlicerApplication::logApplicationInformation() const
 
   int titleIndex = 0;
   // Session start time
+  // Force using en-US locale, otherwise for example on a computer with
+  // Egyptian Arabic (ar-EG) locale, Arabic numerals may be used.
+  QLocale enUsLocale = QLocale(QLocale::English, QLocale::UnitedStates);
   qDebug("%s: %s",
          qPrintable(titles.at(titleIndex++).leftJustified(titleWidth, '.')),
-         qPrintable(QDateTime::currentDateTime().toString("yyyy-MM-dd hh:mm:ss")));
+         qPrintable(enUsLocale.toString(QDateTime::currentDateTime(), "yyyyMMdd_hhmmss")));
 
   // Slicer version
   qDebug("%s: %s (revision %s / %s) %s - %s %s",
diff --git a/Modules/Scripted/DICOMLib/DICOMUtils.py b/Modules/Scripted/DICOMLib/DICOMUtils.py
index ee57152b9b2..f11ba503863 100644
--- a/Modules/Scripted/DICOMLib/DICOMUtils.py
+++ b/Modules/Scripted/DICOMLib/DICOMUtils.py
@@ -972,7 +972,10 @@ def importFromDICOMWeb(
                 outputDirectoryBase = slicer.dicomDatabase.databaseDirectory + "/DICOMweb"
                 if not os.access(outputDirectoryBase, os.F_OK):
                     os.makedirs(outputDirectoryBase)
-                outputDirectoryBase += "/" + qt.QDateTime.currentDateTime().toString("yyyyMMdd-hhmmss")
+                # Force using en-US locale, otherwise for example on a computer with
+                # Egyptian Arabic (ar-EG) locale, Arabic numerals may be used.
+                enUsLocale = qt.QLocale(qt.QLocale.English, qt.QLocale.UnitedStates)
+                outputDirectoryBase += "/" + enUsLocale.toString(qt.QDateTime.currentDateTime(), "yyyyMMdd-hhmmss")
                 outputDirectory = qt.QTemporaryDir(outputDirectoryBase)  # Add unique substring to directory
                 outputDirectory.setAutoRemove(False)
                 outputDirectoryPath = outputDirectory.path()
diff --git a/Modules/Scripted/DICOMLib/Widgets/qSlicerDICOMExportDialog.cxx b/Modules/Scripted/DICOMLib/Widgets/qSlicerDICOMExportDialog.cxx
index eddab522c7c..04fdc78052e 100644
--- a/Modules/Scripted/DICOMLib/Widgets/qSlicerDICOMExportDialog.cxx
+++ b/Modules/Scripted/DICOMLib/Widgets/qSlicerDICOMExportDialog.cxx
@@ -415,7 +415,12 @@ void qSlicerDICOMExportDialog::onExport()
     {
     // Save to temporary folder and store files in database directory when adding
     outputFolder.setPath(qSlicerApplication::application()->temporaryPath());
-    QString tempSubDirName = QString("DICOMExportTemp_%1").arg(QDateTime::currentDateTime().toString("yyyyMMdd_hhmmss"));
+
+    // Force using en-US locale, otherwise for example on a computer with
+    // Egyptian Arabic (ar-EG) locale, Arabic numerals may be used.
+    QLocale enUsLocale = QLocale(QLocale::English, QLocale::UnitedStates);
+    QString tempSubDirName = QString("DICOMExportTemp_%1").arg(enUsLocale.toString(QDateTime::currentDateTime(), "yyyyMMdd_hhmmss"));
+
     outputFolder.mkdir(tempSubDirName);
     outputFolder.cd(tempSubDirName);
     }