From 1aa51a275ce0b7ed4d7dd21a77d47f293872a1c5 Mon Sep 17 00:00:00 2001
From: KianBV <91744358+KianBV@users.noreply.github.com>
Date: Mon, 7 Oct 2024 18:54:17 +0200
Subject: [PATCH] Update index.md

---
 docs/index.md | 6 ++++++
 1 file changed, 6 insertions(+)

diff --git a/docs/index.md b/docs/index.md
index 2a04422..b2a426b 100644
--- a/docs/index.md
+++ b/docs/index.md
@@ -18,9 +18,15 @@ We are developing a novel approach that exploits the ability of the UPS to more
 
 
 ## Our Workflow
+1. Identification of reprogrammable E3 ligases and clinically relevant protein targets.
+2. Construction of a E3-ligase activity driven Phage-Assisted Continous Evolution (PACE) system
+3. Evolution of the E3 ligase towards recognising clinically relevant protein targets
+4. Confirmation of evolved E3 activity in bacterial systems and mammalian cell lines
+5. Further work towards clinical use of the evolved E3 ligase for Targeted Protein Degradation.
 
 ## Key achievements:
 
+
 ## References
 [^ubi_first]:Tsai JM, Nowak RP, Ebert BL, Fischer ES. Targeted protein degradation: from mechanisms to clinic. Nat Rev Mol Cell Biol. 2024;25: 740–757. doi:10.1038/s41580-024-00729-9
 [^ubi_fourth]:Damgaard RB. The ubiquitin system: from cell signalling to disease biology and new therapeutic opportunities. Cell Death Differ. 2021;28: 423–426. doi:10.1038/s41418-020-00703-w