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X-E-M-E-X authored Oct 8, 2024
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Expand Up @@ -19,10 +19,11 @@ We are developing a novel approach that exploits the ability of the UPS to more

## Our Workflow
1. Identification of reprogrammable E3 ligases and clinically relevant protein targets.
2. Construction of a E3-ligase activity driven Phage-Assisted Continous Evolution (PACE) system
3. Evolution of the E3 ligase towards recognising clinically relevant protein targets
4. Confirmation of evolved E3 activity in bacterial systems and mammalian cell lines
5. Further work towards clinical use of the evolved E3 ligase for Targeted Protein Degradation.
2. Construct selection system and test different promoters, linkers, substrates, among other things.
3. Achieve E3 ligase activity dependent phage propagation in the selection system.
4. Evolution of the E3 ligase towards recognising clinically relevant protein targets using Phage-Assisted Continous Evolution (PACE).
5. Confirmation of evolved E3 activity in bacterial system and mammalian cell lines.
6. Further work towards clinical use of the evolved E3 ligase for Targeted Protein Degradation.

## Key achievements:

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