From 4377c675c14fbed7a3872f471eafc85860f24b5f Mon Sep 17 00:00:00 2001 From: KianBV <91744358+KianBV@users.noreply.github.com> Date: Tue, 8 Oct 2024 23:01:09 +0200 Subject: [PATCH] Update background.md --- docs/project/background.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/docs/project/background.md b/docs/project/background.md index 99392b7..d1e8ae2 100644 --- a/docs/project/background.md +++ b/docs/project/background.md @@ -73,7 +73,7 @@ To make this a self-sustaining evolution system, a few more adjustments are need
![Figure_pace](https://idec-teams.github.io/2024_Evolution_Suisse/img/PACE_related_schematics/onlypace.png) -
Figure 4: A schematic representation of the Phage-Assisted Continuous Evolution (PACE) system. Once a phage infects the cell (1), its genome (SP) enters it and the biomolecule that is being evolved is expressed (2). Through a genetic circuit on AP that links the biomolecule activity to _gIII_ expression, the protein pIII, required for phage propagation is expressed (3). In parallel, the phage genome is being replicated (4), with mutations occuring at a higher pace due to the presence of MP. Finally, the newly generated phage genome, structural proteins and pIII assemble into new phage particles. The resulting phages then go on to infect new cells. Should the variant be inactive, pIII is not produced, resulting in non-infectious phages from that cell. New cells are continuously pumped into the lagoon, while old cells and phages are pumped out. +
Figure 4: A schematic representation of the Phage-Assisted Continuous Evolution (PACE) system. Once a phage infects the cell (1), its genome (SP) enters it and the biomolecule that is being evolved is expressed (2). Through a genetic circuit on AP that links the biomolecule activity to gIII expression, the protein pIII, required for phage propagation is expressed (3). In parallel, the phage genome is being replicated (4), with mutations occuring at a higher pace due to the presence of MP. Finally, the newly generated phage genome, structural proteins and pIII assemble into new phage particles. The resulting phages then go on to infect new cells. Should the variant be inactive, pIII is not produced, resulting in non-infectious phages from that cell. New cells are continuously pumped into the lagoon, while old cells and phages are pumped out.