From b341f33b88cd758d39c2bebb940557fe922cdfbd Mon Sep 17 00:00:00 2001 From: noemiesarah Date: Tue, 8 Oct 2024 19:25:30 +0200 Subject: [PATCH] Update index.md --- docs/index.md | 12 +++++++++++- 1 file changed, 11 insertions(+), 1 deletion(-) diff --git a/docs/index.md b/docs/index.md index f5eea17..b85d54f 100644 --- a/docs/index.md +++ b/docs/index.md @@ -25,8 +25,18 @@ We are developing a novel approach that exploits the ability of the UPS to more 6. Further work towards clinical use of the evolved E3 ligase for Targeted Protein Degradation. ## Key achievements: -- We identified promising e3 ligases and targets. +- We identified promising E3 ligases and targets. - We developed an evolutionary logic to evolve these E3 ligases. +- We showed that phage propagation depends on the substrate used and the presence of both RNAP subunits. +- We observed a high background propagation in our system and we came up with possible solutions for the background phage propagation we observed. +- We successfully drifted SIAH1. + +We also: +- We learned the PACE workflow and practiced the setup and operation of the PACE reactor. + +We are currently still working on: +- Achieving E3 ligase activity-dependent phage propagation in the selection system. +- Running PANCE and/or PACE on ## References [^ubi_first]:Tsai JM, Nowak RP, Ebert BL, Fischer ES. Targeted protein degradation: from mechanisms to clinic. Nat Rev Mol Cell Biol. 2024;25: 740–757. doi:10.1038/s41580-024-00729-9