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Update index.md
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BlueShark002 authored Oct 7, 2024
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Expand Up @@ -7,6 +7,5 @@ Extremophiles, known for their ability to thrive in extreme environments, are va

In response, we developed iExtreme, a comprehensive database containing 1,030 genomes of extremophiles across three categories, alongside a deep learning method for their identification. This method achieved an accuracy of up to 0.99 in predicting extremophile living conditions. Through **iExtreme**, we identified 520 previously unknown extremophilic species and 4,419 extremophilic genomes from various databases. Additionally, we utilized structure-based clustering to discover novel D-psicose 3-epimerases (DPEase) and α-amylases. To further enhance enzyme activity, we developed a directed evolution method using phage-assisted non-continuous evolution in droplets. The evolved DPEase demonstrated a 3-fold increase in activity, a 5.4-fold extension in half-life, and achieved the highest reported yield of 243 g/L D-allulose.

![home](./img/home.png)

<center><img src="./img/leiwei.jpg" style="width:150px;"></img></center>
<center>![home](./img/home.png)</img></center>

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