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KpSC_pan_metabolic_model_v2_reaction_metadata.tsv
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KpSC_pan_metabolic_model_v2_reaction_metadata.tsv
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Model ID Name Reaction Subsystem Lower Bound Upper Bound Gene-Protein-Rule (GPR) Reaction Type BiGG ID KEGG ID ModelSEED ID Confidence Score Evidence
10M3OACPO 10-methyl-3-oxo-dodecanoyl-ACP NADP oxidoreductase 3oddecACP_c + h_c + nadph_c <=> nadp_c + 3hoddecACP_c -1000 1000 KPN_01694 Catalytic 10M3OACPO - rxn05372 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
10M3OUO 10-methyl-3-oxo-undecanoyl-ACP NADP oxidoreductase h_c + nadph_c + 10m3ouACP_c <=> nadp_c + 10m3uACP_c -1000 1000 KPN_01694 Catalytic 10M3OUO - rxn05422 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
11M3ODO 11-methyl-3-oxo-dodecanoyl-ACP NADP oxidoreductase h_c + nadph_c + 11m3odACP_c <=> nadp_c + 11m3hdACP_c -1000 1000 KPN_01694 Catalytic 11M3ODO - rxn05397 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
12DGR120tipp "1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C12:0)" 12dgr120_p --> 12dgr120_c Fatty Acid Biosynthesis 0 1000 - Catalytic 12DGR120tipp - rxn07912 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
12DGR140tipp "1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C14:0)" 12dgr140_p --> 12dgr140_c Fatty Acid Biosynthesis 0 1000 - Catalytic 12DGR140tipp - rxn07913 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
12DGR141tipp "1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C14:1)" 12dgr141_p --> 12dgr141_c Fatty Acid Biosynthesis 0 1000 - Catalytic 12DGR141tipp - rxn07914 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
12DGR160tipp "1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C16:0)" 12dgr160_p --> 12dgr160_c Fatty Acid Biosynthesis 0 1000 - Catalytic 12DGR160tipp - rxn07915 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
12DGR161tipp "1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C16:1)" 12dgr161_p --> 12dgr161_c Fatty Acid Biosynthesis 0 1000 - Catalytic 12DGR161tipp - rxn07916 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
12DGR180tipp "1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C18:0)" 12dgr180_p --> 12dgr180_c Fatty Acid Biosynthesis 0 1000 - Catalytic 12DGR180tipp - rxn07917 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
12DGR181tipp "1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C18:1)" 12dgr181_p --> 12dgr181_c Fatty Acid Biosynthesis 0 1000 - Catalytic 12DGR181tipp - rxn07918 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
12ENOD "1,2-Ethanediol:NAD+ oxidoreductase" ethylglycol_c + nad_c <=> gcald_c + nadh_c + h_c -1000 1000 KPN_03150 or 16870_7_51_01432 Catalytic - R01781 rxn01305 2 Evidence in E. coli.
12M3OXOT 12-methyl-3-oxo-tridecanoyl-ACP NADP oxidoreductase h_c + nadph_c + 12m3otACP_c <=> nadp_c + 12mdhtACP_c -1000 1000 KPN_01694 Catalytic 12M3OXOT - rxn05426 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
12M3TDA 2-methyl-3-oxo-tetra-decanoyl-ACP NADP oxidoreductase h_c + nadph_c + 123oxtACP_c <=> nadp_c + 12m3htdACP_c -1000 1000 KPN_01694 Catalytic 12M3TDA - rxn05376 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
12PPDRDH R Propane 1 2 diol dehydratase 12ppd__R_c --> h2o_c + ppal_c 0 1000 KPN_03205 and KPN_03206 and 16703_5_22_02277 and KPN_03208 and K_quasi_quasi_SB98_00881 Catalytic 12PPDRDH - - 2 Transport reaction for known metabolite product (secretion).
12PPDRtex "(R)-Propane-1,2-diol transport via diffusion (extracellular to periplasm)" 12ppd__R_e <=> 12ppd__R_p -1000 1000 KPN_00282 or KPN_01445 or KPN_02636 Transport 12PPDRtex - rxn07919 2 Transport reaction for known metabolite product (secretion).
12PPDRtpp "(R)-Propane-1,2-diol facilitated transport (periplasm)" 12ppd__R_p <=> 12ppd__R_c -1000 1000 - Transport 12PPDRtpp - rxn07920 1 Transport reaction for known metabolite product (secretion). No gene sequence associated with the reaction.
12PPDStex "(S)-Propane-1,2-diol transport via diffusion (extracellular to periplasm)" 12ppd__S_e <=> 12ppd__S_p -1000 1000 KPN_00282 or KPN_01445 or KPN_02636 Transport 12PPDStex - rxn07921 2 Transport reaction for known metabolite product (secretion).
12PPDStpp_copy2 "(S)-Propane-1,2-diol facilitated transport (periplasm)" 12ppd__S_p <=> 12ppd__S_c -1000 1000 16703_5_22_02272 or KPN_04010 Transport 12PPDStpp_copy2 - rxn07921 2 Transport reaction for known metabolite product (secretion).
12PPDt "S-Propane-1,2-diol facilitated transport" 12ppd__S_c <=> 12ppd__S_e -1000 1000 KPN_03202 or 16703_5_22_02272 Transport 12PPDt - rxn07921 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
13M3OTDAO 13-methyl-3-oxo-tetra-decanoyl-ACP NADP oxidoreductase h_c + nadph_c + 13m3otdACP_c <=> nadp_c + 13m3htdACP_c -1000 1000 KPN_01694 Catalytic 13M3OTDAO - - 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
13PPDH "1,3-propanediol dehydrogenase" 3hppnl_c + h_c + nadh_c --> 13ppd_c + nad_c Glycerolipid Metabolism 0 1000 KPN_03491 Catalytic 13PPDH R03119 rxn02235 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
13PPDtex "1,3-propanediol transporter via diffusion (extracellular to periplasm)" 13ppd_e <=> 13ppd_p "Transport, Outer Membrane" -1000 1000 - Transport 13PPDtex - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
13PPDtpp "1,3-propanediol transporter (facilitated diffusion, periplasm)" 13ppd_p <=> 13ppd_c "Transport, Inner Membrane" -1000 1000 - Transport 13PPDtpp - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
14GLUCANabcpp "1,4-alpha-D-glucan transport via ABC system (periplasm)" 14glucan_p + atp_c + h2o_c --> 14glucan_c + adp_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_04423 and KPN_04421 and KPN_04424 and KPN_04422 Transport 14GLUCANabcpp - rxn07923 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
14GLUCANtexi "1,4-alpha-D-glucan transport via diffusion (extracellular to periplasm) irreversible" 14glucan_e --> 14glucan_p "Transport, Outer Membrane" 0 1000 KPN_04425 Transport 14GLUCANtexi - rxn07924 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
14M3OHO 14-methyl-3-oxo-hexa-decanoyl-ACP NADP oxidoreductase h_c + nadph_c + 14m3ohdACP_c <=> nadp_c + 14m3hdACP_c -1000 1000 KPN_01694 Catalytic 14M3OHO - rxn05380 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
14M3OP 14-methyl-3-oxo-pentadecanoyl-ACP NADP oxidoreductase h_c + nadph_c + 14m3opACP_c <=> nadp_c + 14m3hpACP_c -1000 1000 KPN_01694 Catalytic 14M3OP - rxn05430 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
15M3OHAO 15-methyl-3-oxo-hexa-decanoyl-ACP NADP oxidoreductase h_c + nadph_c + 15m3ohdACP_c <=> nadp_c + 15m3hdACP_c -1000 1000 KPN_01694 Catalytic 15M3OHAO - rxn05405 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
1H2NOR 1-hydroxy-2-naphthoate oxidoreductase (NADH) 1h2nap_c + nadh_c + h_c + o2_c <=> npthld_c + co2_c + nad_c + h2o_c -1000 1000 Klebsiella_variicola_INF154_01618 Catalytic - R05632 rxn03906 2 Plasmid encoded in Pseudomonas putida.
1PPDCRc L PipecolateNADP 2 oxidoreductase h_c + nadph_c + 1pipdn2c_c --> nadp_c + Lpipecol_c 0 1000 KPN_04791 Catalytic 1PPDCRc R02203 rxn01579 2 Crystal structure for Pseudomonas putida. 41% Seq ID to structure and bothKPN_04791 and the structure contain the same functional domain (PF02615.14).
1PY4h3cAH 1 Pyrroline 4 hydroxy 2 carboxylate aminohydrolase decyclizing h_c + h2o_c + 1py4h3c_c --> nh4_c + 25dop_c 0 1000 16703_5_14_04599 Catalytic - R02280 rxn01635 2 Evidence in Pseudomonas putida.
235TCDLH "2,3,5-trichlorodienelactone lactonohydrolase" 235diel_c + h2o_c --> 235malac_c 0 1000 KPN_03421 or KPN_04326 or 16870_8_42_00192 Catalytic - R09136 rxn15998 4 KPN_04326 has 99.5% sequence identity to 3F67 protein structure. Evidence that bacteria can utilise these metabolites/reaction.
23CAMPtex 23cAMP transport via diffusion (extracellular to periplasm) 23camp_e <=> 23camp_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport 23CAMPtex - rxn07925 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
23CCMPtex 23cCMP transport via diffusion (extracellular to periplasm) 23ccmp_e <=> 23ccmp_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport 23CCMPtex - rxn07926 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
23CGMPtex 23cGMP transport via diffusion (extracellular to periplasm) 23cgmp_e <=> 23cgmp_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport 23CGMPtex - rxn07927 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
23CTI3 Cis trans isomerization cis trans isomerization 3Z 6Z dodec dienoyl CoA dd_3_6_coa_c --> dd6_2_coa_c 0 1000 KPN_04340 Catalytic - R04756 rxn03254 2 Evidence in E. coli.
23CUMPtex 23cUMP transport via diffusion (extracellular to periplasm) 23cump_e <=> 23cump_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport 23CUMPtex - rxn07928 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
23DAPPAt2pp "2,3-diaminopropionate transport in via proton symport" 23dappa_p + h_p --> 23dappa_c + h_c "Transport, Inner Membrane" 0 1000 - Transport 23DAPPAt2pp - rxn07929 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
23DAPPAtex "2,3-diaminopropionate transport via diffusion" 23dappa_e <=> 23dappa_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport 23DAPPAtex - rxn07930 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
23DK5MPPISO 2;3-diketo-5-methylthiopentyl-1-phosphate enolase dkmpp_c --> hkmpp_c Methionine Metabolism 0 1000 - Catalytic 23DK5MPPISO R07393 rxn05105 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
23PDE2pp "2',3'-cyclic-nucleotide phosphodiesterase (UMP) (periplasm)" 23cump_p + h2o_p --> 3ump_p + h_p Nucleotide Salvage Pathway 0 1000 KPN_04607 Catalytic 23PDE2pp R03538 rxn02522 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
23PDE4pp "2',3'-cyclic-nucleotide phosphodiesterase (CMP) (periplasm)" 23ccmp_p + h2o_p --> 3cmp_p + h_p Nucleotide Salvage Pathway 0 1000 KPN_04607 Catalytic 23PDE4pp R03929 rxn02762 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
23PDE7pp "2',3'-cyclic-nucleotide phosphodiesterase (AMP) (periplasm)" 23camp_p + h2o_p --> 3amp_p + h_p Nucleotide Salvage Pathway 0 1000 KPN_04607 Catalytic 23PDE7pp R03537 rxn02521 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
23PDE9pp "2',3'-cyclic-nucleotide phosphodiesterase (GMP) (periplasm)" 23cgmp_p + h2o_p --> 3gmp_p + h_p Nucleotide Salvage Pathway 0 1000 KPN_04607 Catalytic 23PDE9pp R05135 rxn03483 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
26DAHtex "Meso-2,6-Diaminoheptanedioate transport via diffusion (extracellular to periplasm)" 26dap__M_e <=> 26dap__M_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport 26DAHtex - rxn07931 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2A4H6ET 2-Amino-4-hydroxy-6-erythro-1 2 3-trihydroxypropyl dattoo_c --> ahdt_c + h2o_c + 4.0 h_c 0 1000 KPN_02591 or Klebsiella_pneumoniae_KSB1_9J_01694 Catalytic - R04639 rxn03174 2 Evidence in S. aureus.
2AGPA120tipp 2-Acyl-sn-glycero-3-phosphatidate (n-C12:0) transporter via facilitated diffusion (periplasm) 2ddecg3p_p --> 2ddecg3p_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPA120tipp - rxn07932 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPA140tipp 2-Acyl-sn-glycero-3-phosphatidate (n-C14:0) transporter via facilitated diffusion (periplasm) 2tdecg3p_p --> 2tdecg3p_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPA140tipp - rxn07933 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPA141tipp 2-Acyl-sn-glycero-3-phosphatidate (n-C14:1) transporter via facilitated diffusion (periplasm) 2tdec7eg3p_p --> 2tdec7eg3p_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPA141tipp - rxn07934 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPA160tipp 2-Acyl-sn-glycero-3-phosphatidate (n-C16:0) transporter via facilitated diffusion (periplasm) 2hdecg3p_p --> 2hdecg3p_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPA160tipp - rxn07935 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPA161tipp 2-Acyl-sn-glycero-3-phosphatidate (n-C16:1) transporter via facilitated diffusion (periplasm) 2hdec9eg3p_p --> 2hdec9eg3p_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPA161tipp - rxn07936 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPA180tipp 2-Acyl-sn-glycero-3-phosphatidate (n-C18:0) transporter via facilitated diffusion (periplasm) 2odecg3p_p --> 2odecg3p_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPA180tipp - rxn07937 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPA181tipp 2-Acyl-sn-glycero-3-phosphatidate (n-C18:1) transporter via facilitated diffusion (periplasm) 2odec11eg3p_p --> 2odec11eg3p_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPA181tipp - rxn07938 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPE120tipp 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C12:0) transporter via facilitated diffusion (periplasm) 2agpe120_p --> 2agpe120_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPE120tipp - rxn07939 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPE140tipp 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:0) transporter via facilitated diffusion (periplasm) 2agpe140_p --> 2agpe140_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPE140tipp - rxn07940 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPE141tipp 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:1) transporter via facilitated diffusion (periplasm) 2agpe141_p --> 2agpe141_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPE141tipp - rxn07941 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPE160tipp 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:0) transporter via facilitated diffusion (periplasm) 2agpe160_p --> 2agpe160_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPE160tipp - rxn07942 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPE161tipp 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:1) transporter via facilitated diffusion (periplasm) 2agpe161_p --> 2agpe161_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPE161tipp - rxn07943 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPE180tipp 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:0) transporter via facilitated diffusion (periplasm) 2agpe180_p --> 2agpe180_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPE180tipp - rxn07944 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPE181tipp 2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:1) transporter via facilitated diffusion (periplasm) 2agpe181_p --> 2agpe181_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPE181tipp - rxn07945 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPEAT120 2-acyl-glycerophospho-ethanolamine acyltransferase (n-C12:0) 2agpe120_c + atp_c + ddca_c --> amp_c + pe120_c + ppi_c Glycerophospholipid Metabolism 0 1000 KPN_03245 Catalytic 2AGPEAT120 - rxn07946 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPEAT140 2-acyl-glycerophospho-ethanolamine acyltransferase (n-C14:0) 2agpe140_c + atp_c + ttdca_c --> amp_c + pe140_c + ppi_c Glycerophospholipid Metabolism 0 1000 KPN_03245 Catalytic 2AGPEAT140 - rxn07947 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPEAT141 2-acyl-glycerophospho-ethanolamine acyltransferase (n-C14:1) 2agpe141_c + atp_c + ttdcea_c --> amp_c + pe141_c + ppi_c Glycerophospholipid Metabolism 0 1000 KPN_03245 Catalytic 2AGPEAT141 - rxn07948 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPEAT160 2-acyl-glycerophospho-ethanolamine acyltransferase (n-C16:0) 2agpe160_c + atp_c + hdca_c --> amp_c + pe160_c + ppi_c Glycerophospholipid Metabolism 0 1000 KPN_03245 Catalytic 2AGPEAT160 - rxn07949 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPEAT161 2-acyl-glycerophospho-ethanolamine acyltransferase (n-C16:1) 2agpe161_c + atp_c + hdcea_c --> amp_c + pe161_c + ppi_c Glycerophospholipid Metabolism 0 1000 KPN_03245 Catalytic 2AGPEAT161 - rxn07950 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPEAT180 2-acyl-glycerophospho-ethanolamine acyltransferase (n-C18:0) 2agpe180_c + atp_c + ocdca_c --> amp_c + pe180_c + ppi_c Glycerophospholipid Metabolism 0 1000 KPN_03245 Catalytic 2AGPEAT180 - rxn07951 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPEAT181 2-acyl-glycerophospho-ethanolamine acyltransferase (n-C18:1) 2agpe181_c + atp_c + ocdcea_c --> amp_c + pe181_c + ppi_c Glycerophospholipid Metabolism 0 1000 KPN_03245 Catalytic 2AGPEAT181 - rxn07952 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPG120tipp 2-Acyl-sn-glycero-3-phosphoglycerol (n-C12:0) transporter via facilitated diffusion (periplasm) 2agpg120_p --> 2agpg120_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPG120tipp - rxn07953 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPG140tipp 2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:0) transporter via facilitated diffusion (periplasm) 2agpg140_p --> 2agpg140_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPG140tipp - rxn07954 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPG141tipp 2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1) transporter via facilitated diffusion (periplasm) 2agpg141_p --> 2agpg141_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPG141tipp - rxn07955 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPG160tipp 2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0) transporter via facilitated diffusion (periplasm) 2agpg160_p --> 2agpg160_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPG160tipp - rxn07956 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPG161tipp 2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1) transporter via facilitated diffusion (periplasm) 2agpg161_p --> 2agpg161_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPG161tipp - rxn07957 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPG180tipp 2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0) transporter via facilitated diffusion (periplasm) 2agpg180_p --> 2agpg180_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPG180tipp - rxn07958 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPG181tipp 2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1) transporter via facilitated diffusion (periplasm) 2agpg181_p --> 2agpg181_c "Transport, Inner Membrane" 0 1000 KPN_03244 Transport 2AGPG181tipp - rxn07959 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPGAT120 2-acyl-glycerophospho-glycerol acyltransferase (n-C12:0) 2agpg120_c + atp_c + ddca_c --> amp_c + pg120_c + ppi_c Glycerophospholipid Metabolism 0 1000 KPN_03245 Catalytic 2AGPGAT120 - rxn07960 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPGAT140 2-acyl-glycerophospho-glycerol acyltransferase (n-C14:0) 2agpg140_c + atp_c + ttdca_c --> amp_c + pg140_c + ppi_c Glycerophospholipid Metabolism 0 1000 KPN_03245 Catalytic 2AGPGAT140 - rxn07961 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPGAT141 2-acyl-glycerophospho-glycerol acyltransferase (n-C14:1) 2agpg141_c + atp_c + ttdcea_c --> amp_c + pg141_c + ppi_c Glycerophospholipid Metabolism 0 1000 KPN_03245 Catalytic 2AGPGAT141 - rxn07962 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPGAT160 2-acyl-glycerophospho-glycerol acyltransferase (n-C16:0) 2agpg160_c + atp_c + hdca_c --> amp_c + pg160_c + ppi_c Glycerophospholipid Metabolism 0 1000 KPN_03245 Catalytic 2AGPGAT160 - rxn07963 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPGAT161 2-acyl-glycerophospho-glycerol acyltransferase (n-C16:1) 2agpg161_c + atp_c + hdcea_c --> amp_c + pg161_c + ppi_c Glycerophospholipid Metabolism 0 1000 KPN_03245 Catalytic 2AGPGAT161 - rxn07964 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPGAT180 2-acyl-glycerophospho-glycerol acyltransferase (n-C18:0) 2agpg180_c + atp_c + ocdca_c --> amp_c + pg180_c + ppi_c Glycerophospholipid Metabolism 0 1000 KPN_03245 Catalytic 2AGPGAT180 - rxn07965 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2AGPGAT181 2-acyl-glycerophospho-glycerol acyltransferase (n-C18:1) 2agpg181_c + atp_c + ocdcea_c --> amp_c + pg181_c + ppi_c Glycerophospholipid Metabolism 0 1000 KPN_03245 Catalytic 2AGPGAT181 - rxn07966 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2C5DLH dienelactone hydrolase 2c5mdiel_c + h2o_c <=> 2c5malac_c -1000 1000 KPN_03421 or KPN_04326 or 16870_8_42_00192 Catalytic - R09222 rxn16084 4 KPN_04326 has 99.5% sequence identity to 3F67 protein structure. Evidence that bacteria can utilise these metabolites/reaction.
2CLMLCMB 2-Chloromaleylacetate Carboxymethylenebutenolidase 2cldl_c + h2o_c --> 2clma_c 0 1000 KPN_03421 or KPN_04326 or 16870_8_42_00192 Catalytic - R05511 rxn03801 4 KPN_04326 has 99.5% sequence identity to 3F67 protein structure. Evidence that bacteria can utilise these metabolites/reaction.
2D5HMCPT 2'-deoxy-5-hydroxymethylcytidine-5'-diphosphate phosphotransferase 2d5hmcdp_c + atp_c + h_c --> 2d5hmctp_c + adp_c 0 1000 KPN_02848 Catalytic - R00139 rxn00107 2 Evidence in E. coli and mentioned in genome annotations/virulence genes in Klebsiella.
2DGLCNRx 2-dehydro-D-gluconate reductase (NADH) 2dhglcn_c + h_c + nadh_c --> glcn_c + nad_c Alternate Carbon Metabolism 0 1000 KPN_03915 Catalytic 2DGLCNRx - rxn07967 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2DGLCNRy 2-dehydro-D-gluconate reductase (NADPH) 2dhglcn_c + h_c + nadph_c --> glcn_c + nadp_c Alternate Carbon Metabolism 0 1000 KPN_03915 Catalytic 2DGLCNRy R01739 rxn01277; rxn14160 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2DGLCNRz 2-dehydro-D-gluconate reductase (FAD) glcn_c + fad_c <=> 2dhglcn + fadh2_c -1000 1000 (KPN_02084 and KPN_02083) or (Klebsiella_variicola_KSB1_9F_02242 and 16870_7_82_02751) Catalytic - R01741 rxn01279 2 Evidence from Gluconobacter oxydans.
2DGLCptspp 2-Deoxy-D-glucose transport via PEP:Pyr PTS (periplasm) 2dglc_p + pep_c --> 2doxg6p_c + pyr_c 0 1000 KPN_02762 and KPN_02333 and KPN_02335 and KPN_02763 and KPN_02334 Transport 2DGLCptspp - - 2 Transport reaction for potential growth substrate/biofilm inhibiter.
2DGLCtex 2-Deoxy-D-glucose transport via diffusion (extracellular) 2dglc_e <=> 2dglc_p -1000 1000 KPN_01445 or KPN_00282 or KPN_02636 Transport 2DGLCtex - - 2 Transport reaction for potential growth substrate/biofilm inhibiter.
2DGULRGx 2-Dehydro-L-gulonate reductase to gluconate (NADH) 2dhguln_c + h_c + nadh_c --> glcn_c + nad_c 0 1000 KPN_03915 Catalytic 2DGULRGx - - 2 Evidence in E. coli. Also shows potential for there to be multiple orthologs within a species.
2DGULRGy 2-Dehydro-L-gulonate reductase to gluconate (NADPH) 2dhguln_c + h_c + nadph_c --> glcn_c + nadp_c 0 1000 KPN_03915 Catalytic 2DGULRGy - - 2 Evidence in E. coli. Also shows potential for there to be multiple orthologs within a species.
2DGULRx 2-dehydro-L-gulonate reductase (NADH) 2dhguln_c + h_c + nadh_c --> idon__L_c + nad_c Alternate Carbon Metabolism 0 1000 KPN_03915 Catalytic 2DGULRx - rxn07969 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2DGULRy 2-dehydro-L-gulonate reductase (NADPH) 2dhguln_c + h_c + nadph_c --> idon__L_c + nadp_c Alternate Carbon Metabolism 0 1000 KPN_03915 Catalytic 2DGULRy R08880 rxn07970 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2DHTTIM 2-dehydrotetronate isomerase 2der_c <=> 3der_c -1000 1000 KPN_01602 Catalytic - R11722 - 2 Evidence in bacteria and presence of chromosomal ygb operon (catalytic protein) in Klebsiella.
2FBZHEX "2-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate degradation" 2fcl12d1c_c --> catechol_c + co2_c + h_c + f_c 0 1000 - Catalytic - R08122 rxn07910 1 No gene-protein-rule associated with this reaction. Required for modelling 2fbz but unknown what protein catalyses this reaction (no KEGG ortholog associated with the reaction).
2FBZOR 2-fluorobenzoate oxidoreductase 2fbz_c + nadh_c + h_c + o2_c --> 2fcl12d1c_c + nad_c 0 1000 KPN_01872 and KPN_01871 and KPN_01870 Catalytic - R08100 rxn07889 2 Direct evidence in Acinetobacter and indirect evidence that Klebsiella can utilise this pathway.
2FBZOR_2 "2-fluorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" 2fbz_c + nadh_c + h_c + o2_c --> 6fcl12d1c_c + nad_c 0 1000 KPN_01872 and KPN_01871 and KPN_01870 Catalytic - R08101 rxn07890 2 Direct evidence in Acinetobacter and indirect evidence that Klebsiella can utilise this pathway.
2FBZt 2-fluorobenzoate transport (diffusion) 2fbz_e <=> 2fbz_c -1000 1000 KPN_SPONT Transport - - - 1 Indirect evidence that Klebsiella can utilise this pathway.
2H3KDGH 2-hydroxy-3-keto-D-glucose Hydration 2h3kdg_c + h2o_c --> 3kglu__D_c + 2 h_c 0 1000 - Catalytic - - - 2 Evidence that Klebsiella can degrade levoglucosan.
2H4O124THL "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase" 4o1e124tc_c + h2o_c --> 4c4h2op_c 0 1000 KPN_04049 Catalytic - R04478 rxn03089 2 Evidence in Psuedomonas putida.
2HBUTt 2 Hydroxybutyrate transport 2hbut_e <=> 2hbut_p -1000 1000 - Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
2HBUTtpp 2 Hydroxybutyrate transport (periplasm) 2hbut_p <=> 2hbut_c -1000 1000 - Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
2HESR 2-hydroxyethyldisulfide reductase dtgcl_c + 2.0 gthrd_c --> gthox_c + 2.0 mercpeth_c 0 1000 KPN_03419 or KPN_02692 or KPN_02691 or KPN_03940 or KPN_01973 or KPN_00870 or KPN_03867 or Klebsiella_pneumoniae_kppr1.contigset_02786 or KPN_04464 or Klebsiella_variicola_KSB2_3A_02496 Catalytic 2HESR R03522 rxn06401 2 Gltathione-S-transferase can be plasmid-encoded in E. coli and are chromosome encoded in Klebsiella.
2HH24DDH 2hh24dd hydratase 2hh24dd_c + h2o_c --> 4h2kpi_c 0 1000 KPN_04784 Catalytic 2HH24DDH - - 2 Part of the 4-hydroxyphenylacetate degradation pathway which Klebsiella is known to at least catabolise.
2HH24DDH1_copy1 2hh24dd hydratase 2hh24dd_c + h2o_c --> 24dhhed_c 0 1000 KPN_04784 Catalytic - - - 2 Part of the 4-hydroxyphenylacetate degradation pathway which Klebsiella is known to at least catabolise.
2HH24DDH1_copy2 2hh24dd hydratase 2hh24dd_c + h2o_c <=> 24dhhed_c -1000 1000 KPN_04784 Catalytic - - - 2 Part of the 4-hydroxyphenylacetate degradation pathway which Klebsiella is known to at least catabolise.
2HPTCOAT "2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA thioesterase" 2hptcoa_c + h2o_c --> 2hptcl_c + coa_c 0 1000 KPN_01481 Catalytic 2HPTCOAT - - 2 Part of pathway for degrading phenylacetic acid in E. coli which regulates antibiotic stress responses.
2IBAH 2-iminobutanoate aminohydrolase 2ibt_c + h2o_c --> 2obut_c + nh4_c 0 1000 KPN_04416 or 16703_5_45_02483 or KPN_04655 Catalytic - R11098 - 2 "Evidence in Salmonella and curated Salmonella sequence (https://www.uniprot.org/uniprot/Q7CP78) also has the same functional domain and sequence length. Only KPN_04655 (96%), KPN_04416 (75%) and 16703_5_45_02483 (73%) had reasonable sequence identities."
2IBSPONT Spontaneous 2-iminobutanoate Conversion 2ab2e_c --> 2ibt_c 0 1000 KPN_SPONT Catalytic - R11101 - 1 Spontaneous reaction that occurs prior to 2IBAH (R11098).
2INSD 2-Inosose dehydratase 2ins_c --> h2o_c + dkdi_c 0 1000 KPN_04677 or KPN_00504 or 16703_5_14_01998 or 16703_7_86_05344 or KPN_01796 Catalytic 2INSD R02782; R05659 rxn02007 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2IPAH 2-iminopropanoate aminohydrolase 2iprop_c + h2o_c --> pyr_c + nh4_c 0 1000 KPN_04416 or 16703_5_45_02483 or KPN_04655 Catalytic - R11099 - 2 Evidence of catalytic protein in Salmonella.
2IPSPONT Spontaneous 2-iminopropanoate Conversion dhala_c --> 2iprop_c 0 1000 KPN_SPONT Catalytic - R11100 - 1 Spontaneous reaction that occurs prior to 2IPAH (R11099).
2K4PH 2-keto-4-pentenoate hydratase 4c4h2op_c <=> 4c2o3hd_c + h2o_c -1000 1000 KPN_02119 or Klebsiella_pneumoniae_INF161_04890 Catalytic - R04781 rxn03272 2 Evidence in E. coli.
2KMINOI 2-keto-myo-inositol isomerase 1kdinost_c <=> 2ins_c -1000 1000 KPN_04669 Catalytic - R09952 rxn16799 2 Evidence in Salmonella.
2MAHMP 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphatase 2mahmp_c + h2o_c --> 4ampm_c + h_c + pi_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_00408 or KPN_01142 Catalytic 2MAHMP - rxn07971 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2OAT 2-oxoglutarate aminotransferase oaa_c + Largn_c <-- asp__L_c + pphn_c -1000 0 KPN_04441 or KPN_01365 Catalytic - R01731 rxn01270 2 Evidence in E. coli and Klebsiella.
2OBUT_Et 2-Oxobutanoate transport (transport mechanism unknown - evidence from biolog data) 2obut_e --> 2obut_c Transport 0 1000 - Transport 2OBUT_Et - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2OH3K5MPPISO 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase h2o_c + hkmpp_c --> dhmtp_c + pi_c Methionine Metabolism 0 1000 - Catalytic 2OH3K5MPPISO R07394 rxn05106; rxn11033 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
2OXOADOX 2-oxoadipate dehydrogenase complex (cytoplasm) 2oxoadp_c + coa_c + nad_c --> co2_c + nadh_c + glutcoa_c 0 1000 (KPN_00733 and KPN_00120) or Klebsiella_pneumoniae_KSB2_1C_04030 or KPN_00732 Catalytic - R01933 rxn01418 2 Evidence in E. coli (protein structure) suggesting this reaction can also occur in Bacteria.
2PAHL 2-phenylacetamide hydro-lyase (nitrile-forming) pan_c + h2o_c <=> pad_c -1000 1000 Klebsiella_variicola_KSB2_3A_02578 and Klebsiella_variicola_KSB2_3A_02579 Catalytic - R07854 rxn07644 2 Evidence in bacteria.
2PGt6pp D Glycerate 2 phosphate phosphate antiporter periplasm 2pg_p + pi_c --> 2pg_c + pi_p 0 1000 KPN_01724 Transport 2PGt6pp - rxn05474 2 Transport reaction for substrate that can be simulated by the model.
2PGtex D Glycerate 2 phosphate transport via diffusion extracellular to periplasm 2pg_e <=> 2pg_p -1000 1000 KPN_00282 or KPN_00956 or KPN_01445 or KPN_02636 Transport 2PGtex - - 2 Transport reaction for substrate that can be simulated by the model.
2PHACTE Phenylacetyl CoA thioesterase 2hphaccoa_c + h2o_c --> 2hyoxplac_c + coa_c + 5.0 h_c 0 1000 KPN_01477 Catalytic 2PHACTE - - 2 Structural evidence in S. pneumoniae and genomic evidence in Klebsiella.
34DHALDD Aldehyde dehydrogenase 3 4 dihydroxyphenylacetaldehyde NAD 34dhpac_c + h2o_c + nad_c --> 34dhpha_c + 2.0 h_c + nadh_c 0 1000 KPN_01455 or 16852_1_74_04792 Catalytic 34DHALDD R03300 rxn02364 2 Evidence of catalytic protein in E. coli.
34DHOXPEGOX "3,4-Dihydroxyphenylethyleneglycol NAD+ oxidoreductase" h_c + nadh_c + 34dhmald_c <=> nad_c + 34dhoxpeg_c -1000 1000 Klebsiella_variicola_INF336_05720 or KPN_01952 or KPN_02199 or KPN_01853 or KPN_03491 Catalytic - R04880 rxn03333 2 Evidence in E. coli.
34DHPACDO 3 4 dihydroxyphenylacetate 2 3 dioxygenase 34dhpacet_c + o2_c --> 5cmhmsa_c + h_c 0 1000 KPN_04786 Catalytic 34DHPACDO R03303 rxn02366 2 Part of the 4-hydroxyphenylacetate degradation pathway which Klebsiella is known to at least catabolise.
34dhpactex Dihydroxyphenylacetaldehyde transport via diffusion (extracellular to periplasm) 34dhpac_e <=> 34dhpac_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport 34dhpactex - rxn07972 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
34PHACTE Phenylacetyl CoA thioesterase 34dhphaccoa_c --> 34dhpac_c + coa_c + 2.0 h_c 0 1000 KPN_01477 Catalytic 34PHACTE - - 2 Structural evidence in S. pneumoniae and genomic evidence in Klebsiella.
35DB4HBNAH "3,5-dibromo-4-hydroxybenzonitrile aminohydrolase" bxynil_c + 2 h2o_c + h_c <=> 35db4hbz_c + nh4_c 0 1000 K_variicola_variicola_F2R9T_03207 Catalytic - R04349 rxn03021 2 Catalytic reaction is associated with Klebsiella growth substrate. No threshold was associated with the KEGG ortholog so used the most significant sequence. K_variicola_variicola_F2R9T_03207 already produced a significant hit to a generic nitrilase (K01501) so the catalytic mechanism for the included gene is at least correct.
35DB4HBNH "3,5-dibromo-4-hydroxybenzamide Nitrile Hydratase" bxynil_c + h2o_c --> 35dv4hba_c 0 1000 Klebsiella_variicola_KSB2_3A_02578 and Klebsiella_variicola_KSB2_3A_02579 Catalytic - R07780 rxn07594 2 Catalytic reaction is associated with Klebsiella growth substrate.
35PHACTE Phenylacetyl CoA thioesterase 35dhphaccoa_c + h2o_c --> 35dhpha_c + coa_c + 4.0 h_c 0 1000 KPN_01477 Catalytic 35PHACTE - - 2 Structural evidence in S. pneumoniae and genomic evidence in Klebsiella.
3AMACHYD 3-aminoacrylate hydrolase 3amac_c + h_c + h2o_c --> msa_c + nh4_c 0 1000 KPN_01035 Catalytic - R09983 rxn16829 2 Indirect evidence of the Rut operon in Klebsiella but direct evidence in E. coli and Salmonella.
3AMPtex 3AMP transport via diffusion (extracellular to periplasm) 3amp_e <=> 3amp_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport 3AMPtex - rxn07973 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3BZOR 3-Benzoate Oxidoreduction bz_c + h2o_c --> 3hbz_c + h_c 0 1000 KPN_SPONT Catalytic - R01427 rxn01040 1 Required for 3HBNO. Incomplete evidence of this reaction but evidence of following reactions in Klebsiella.
3C2DLH dienelactone hydrolase 3c2diel_c + h2o_c --> 3c2malac_c 0 1000 KPN_03421 or KPN_04326 or 16870_8_42_00192 Catalytic - R09220 rxn16082 4 KPN_04326 has 99.5% sequence identity to 3F67 protein structure. Evidence that bacteria can utilise these metabolites/reaction.
3CCCMD "3-Chloro-cis,cis-muconate degradation" 3clccmuac_c --> 4meb2e4o_c + cl_c + co2_c + h_c 0 1000 KPN_01875 Catalytic - R05390 rxn03691 2 Protein evidence in Pseudomonas putida. Protoanemonin is a plant toxin (not produced by bacteria but possibly degraded).
3CMPtex 3CMP transport via diffusion (extracellular to periplasm) 3cmp_e <=> 3cmp_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport 3CMPtex - rxn07974 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3D4PDECL 3-dehydro-4-phospho-D-erythronate carboxy-lyase 3d4per_c <=> dhap_c + co2_c + 2.0 h_c -1000 1000 KPN_01603 or K_quasi_quasi_01A030T_02469 Catalytic - R11717 - 2 Evidence in E. coli.
3DHTT4K 3-dehydrotetronate 4-kinase atp_c + 3der_c + h_c <=> adp_c + 3d4per_c -1000 1000 KPN_01604 or K_quasi_quasi_01A030T_02468 Catalytic - R11707 - 2 Evidence in bacteria and presence of chromosomal ygb operon (catalytic protein) in Klebsiella.
3FBZOR "3-fluorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" 3fbz_c + nadh_c + h_c + o2_c --> 3fcl12d1c_c + nad_c 0 1000 KPN_01872 and KPN_01871 and KPN_01870 Catalytic - R08108 rxn07896 2 Evidence in Acinetobacter and literature suggesting Klebsiella can utilise this pathway.
3FBZOR_2 "3-fluorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" 3fbz_c + nadh_c + h_c + o2_c --> 5fcl12d1c_c + nad_c 0 1000 KPN_01872 and KPN_01871 and KPN_01870 Catalytic - R08109 rxn07897 2 Evidence in Acinetobacter and literature suggesting Klebsiella can utilise this pathway.
3FBZt 3-fluorobenzoate transport (diffusion) 3fbz_e <=> 3fbz_c -1000 1000 KPN_SPONT Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
3FCCOR "3-fluorocatechol:oxygen 1,2-oxidoreductase" 3fcc_c + o2_c --> 2fccm_c 0 1000 KPN_01873 Catalytic - R08114 rxn07902 2 Evidence in Acinetobacter and literature suggesting Klebsiella can utilise this pathway.
3GMPtex 3GMP transport via diffusion (extracellular to periplasm) 3gmp_e <=> 3gmp_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport 3GMPtex - rxn07975 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3H3HEX 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming) 3h3ihexgcoa_c --> 7m3o7ncoa_c + ac_c + h_c 0 1000 16703_7_36_05045 or K_variicola_tropicalensis_CDC4241-71_03905 Catalytic - R08090 rxn07879 2 Protein structure from Bacillus (1YDO) was compared all sequences and shown to have the same functional domain (PF00682.19) according to pfam-scan. Sequences had 39-48% sequence identity but most likely the same protein (low identity as not closely related species).
3H5MH4ECHL 3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase 5mh24dcoa_c + h2o_c --> 3h5mh4ecoa_c 0 1000 KPN_01475 or KPN_01474 or 16780_6_39_00662 or KPN_02723 or KPN_04340 Catalytic - R08093 rxn07882 2 Evidence in Mycobacterium. Geraniol is produced by plants and can be used to increase antibiotic suspectibility in E. coli and Salmonella.
3H5MH4ECOX 3-hydroxy-5-methylhex-4-enoyl-CoA Oxidoreductase 3h5mh4ecoa_c + nad_c --> 5m3o4hcoa_c + nadh_c + h_c 0 1000 KPN_02723 or KPN_04340 Catalytic - R08094 rxn07883 2 Evidence in Mycobacterium. Geraniol is produced by plants and can be used to increase antibiotic suspectibility in E. coli and Salmonella.
3HAD100 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C10:0) 3hdecACP_c --> h2o_c + tdec2eACP_c Cell Envelope Biosynthesis 0 1000 KPN_00193 or KPN_00983 Catalytic 3HAD100 R04535 rxn05333 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3HAD120 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C12:0) 3hddecACP_c --> h2o_c + tddec2eACP_c Cell Envelope Biosynthesis 0 1000 KPN_00193 or KPN_00983 Catalytic 3HAD120 R04965 rxn05331 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3HAD121 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C12:1) 3hcddec5eACP_c --> h2o_c + t3c5ddeceACP_c Cell Envelope Biosynthesis 0 1000 KPN_00193 or KPN_00983 Catalytic 3HAD121 - rxn07976 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3HAD140 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C14:0) 3hmrsACP_c --> h2o_c + tmrs2eACP_c Cell Envelope Biosynthesis 0 1000 KPN_00193 or KPN_00983 Catalytic 3HAD140 R04568 rxn05335 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3HAD141 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C14:1) 3hcmrs7eACP_c --> h2o_c + t3c7mrseACP_c Cell Envelope Biosynthesis 0 1000 KPN_00983 or KPN_00193 Catalytic 3HAD141 - rxn07977 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3HAD160 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C16:0) 3hpalmACP_c --> h2o_c + tpalm2eACP_c Cell Envelope Biosynthesis 0 1000 KPN_00983 or KPN_00193 Catalytic 3HAD160 R04544 rxn05332 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3HAD161 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C16:1) 3hcpalm9eACP_c --> h2o_c + t3c9palmeACP_c Cell Envelope Biosynthesis 0 1000 KPN_00193 or KPN_00983 Catalytic 3HAD161 - rxn07978 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3HAD180 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C18:0) 3hoctaACP_c --> h2o_c + toctd2eACP_c Cell Envelope Biosynthesis 0 1000 KPN_00983 or KPN_00193 Catalytic 3HAD180 R07764 rxn07979 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3HAD181 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C18:1) 3hcvac11eACP_c --> h2o_c + t3c11vaceACP_c Cell Envelope Biosynthesis 0 1000 KPN_00193 or KPN_00983 Catalytic 3HAD181 - rxn07980 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3HAD40 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C4:0) 3haACP_c --> but2eACP_c + h2o_c Cell Envelope Biosynthesis 0 1000 KPN_00193 or KPN_00983 Catalytic 3HAD40 R04428 rxn07981; rxn05329 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3HAD60 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C6:0) 3hhexACP_c --> h2o_c + thex2eACP_c Cell Envelope Biosynthesis 0 1000 KPN_00983 or KPN_00193 Catalytic 3HAD60 R04954 rxn05330 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3HAD80 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C8:0) 3hoctACP_c --> h2o_c + toct2eACP_c Cell Envelope Biosynthesis 0 1000 KPN_00193 or KPN_00983 Catalytic 3HAD80 R04537 rxn05334 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3HAOR 3-Hydroxyoctodecanoyl-ACP NADP oxidoreductase h_c + nadph_c + 3oodACP_c <=> nadp_c + 3hodACP_c -1000 1000 KPN_01694 Catalytic 3HAOR - rxn05461 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
3HBCOAHL 3-hydroxyisobutyryl-CoA hydrolase 3hibutcoa_c + h2o_c --> 3hmp_c + coa_c + h_c 0 1000 16780_6_39_00662 or Klebsiella_pneumoniae_INF334_04443 Catalytic 3HBCOAHL R05064 rxn03433 2 Reaction involves human metabolites. Evidence in Sinorhizobium for nitrogen fixation.
3HBNO 3-hydroxybenzoate NADH Oxidoreductase (6-hydroxylating) 3hbz_c + o2_c + nadh_c + h_c --> 25dhb_c + nad_c + h2o_c 0 1000 Klebsiella_variicola_INF154_01618 Catalytic - R02589 rxn01884 4 Evidence of the catalytic protein in Klebsiella.
3HBZCT 3-hydroxybenzoyl-CoA thioesterase 3hbzcoa_c + h2o_c --> 3hbz_c + coa_c 0 1000 KPN_00615 Catalytic 3HBZCT - - 2 Evidence of catalytic pathway in Klebsiella (for reaction end product).
3HCINNMH 3-hydroxycinnamate hydroxylase 3hcinnm_c + h_c + nadh_c + o2_c --> dhcinnm_c + h2o_c + nad_c Alternate Carbon Metabolism 0 1000 KPN_02122 Catalytic 3HCINNMH R06787 rxn04602 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3HOPCD 3-hydroxypimeloyl-CoA dehydrogenase nad_c + 3hpimcoa_c <=> h_c + nadh_c + 3opimcoa_c -1000 1000 KPN_02723 or KPN_04340 Catalytic - R05305 rxn03617 2 Evidence in E. coli.
3HOXPACt2pp HPA permease 3hoxpac_p + h_p --> 3hoxpac_c + h_c 0 1000 HMPHIOOD_04460 or KPN_04782 Transport 3HOXPACt2pp - - 2 Transport reaction for known Klebsiella growth substrate.
3hoxpactex 3 hydroxyphenylacetic acid transport via diffusion extracellular to periplasm 3hoxpac_e <=> 3hoxpac_p -1000 1000 KPN_00282 or KPN_00956 or KPN_01445 or KPN_02636 Transport 3hoxpactex - - 2 Evidence that Klebsiella can catabolize this metabolite which implies it can be imported into the cell. Corresponds to an OMP porin which is known to have four-five genes in the gene-protein-rule (Eg: 23CAMPtex). KPN_00956 (corresponding to ompF) does not have an ortholog in E. coli but does have one in Salmonella (Eg: 2PGtex). Therefore the missing gene has been included into the gene-protein-rule without sequence evidence.
3HPADHi 3-Hydroxypropanal Dehydrogenase 3hppnl_c + h2o_c + nad_c --> 3hpp_c + 2.0 h_c + nadh_c 0 1000 KPN_01018 Catalytic 3HPADHi - - 2 Evidence of catalytic pathway in Klebsiella (industrial).
3HPAOX HPA monooxygenase 3hoxpac_c + nadh_c + o2_c --> 34dhpha_c + h2o_c + nad_c 0 1000 KPN_04779 and KPN_04780 Catalytic 3HPAOX R03299 rxn02363 2 Genomic evidence of pathway in Klebsiella.
3HPPPNH 3-(3-hydroxy-phenyl)propionate hydroxylase 3hpppn_c + h_c + nadh_c + o2_c --> dhpppn_c + h2o_c + nad_c Alternate Carbon Metabolism 0 1000 KPN_02122 Catalytic 3HPPPNH R06786 rxn04601 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3HPPtex 3-hydroxypropionate transport via diffusion (extracellular to periplasm) 3hpp_e <=> 3hpp_p -1000 1000 KPN_01445 or KPN_00282 or KPN_02636 Transport 3HPPtex - rxn29193 2 Transport reaction for substrate that can be simulated by the model.
3HPPtpp 3-hydroxypropionate transport via proton symport (periplasm) 3hpp_c + h_c --> 3hpp_p + h_p 0 1000 - Transport 3HPPtpp - - 1 Transport reaction for substrate that can be simulated by the model. No gene sequence associated with the reaction.
3IPMHL "(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)" 3c2hmp_c + 2.0 h_c <=> a2ippm_c -1000 1000 (K_quasi_quasi_18A069_01744 and K_quasi_quasi_18A069_01743) or (16870_8_84_04763 and 16870_8_84_04762) or (KPN_00078 and KPN_00077) Catalytic - R10170 rxn12193 2 Evidence in bacteria.
3KDGOx 3-keto-D-glucose Oxidation 3kglu__D_c + nadh_c + h_c --> glc__D_c + nad_c 0 1000 - Catalytic - - - 2 Evidence that Klebsiella can degrade metabolite the pathway is associated with.
3KGK 3-keto-L-gulonate kinase 3dhguln_c + atp_c --> 3dhgulnp_c + adp_c + h_c 0 1000 16703_5_14_02281 Catalytic 3KGK R07127 rxn04930 2 Evidence in E. coli.
3KLGC 3-keto-levoglucosan conversion 3klevoglu_c + h_c --> 2h3kdg_c 0 1000 - Catalytic - - - 2 Evidence that Klebsiella can degrade metabolite the pathway is associated with.
3MBZALDH Benzyl alcohol dehydrogenase nad_c + 3mbzalc_c --> h_c + nadh_c + 3mbzald_c 0 1000 Klebsiella_variicola_KSB2_3A_05265 or KPN_01945 Catalytic - R05347 rxn03649 2 Evidence of being plasmid-encoded in Pseudomonas and that Klebsiella can degrade xylene.
3MBZDH Benzaldehyde dehydrogenase h2o_c + nad_c + 3mbzald_c --> 2.0 h_c + nadh_c + m_tol_c 0 1000 KPN_01919 Catalytic - R05664 rxn03935 2 Evidence that Kp can breakdown xylene. Although KEGG ortholog hit was significant it is just below the threshold. It was included however as this sequence has no other significant hits.
3MCCAT 3-methylcrotonyl-CoA C-acyltransferase 5m3o4hcoa_c + coa_c --> 3mb2coa_c + accoa_c 0 1000 KPN_01540 or 16870_8_36_00858 or KPN_01478 Catalytic - R08095 rxn07884 2 Evidence in Mycobacterium. Geraniol is produced by plants and can be used to increase antibiotic suspectibility in E. coli and Salmonella.
3MSCH 3-Methylsalicylate hydroxylase msial_c + o2_c + nadh_c + h_c <=> 3mcat_c + nad_c + co2_c + h2o_c -1000 1000 Klebsiella_variicola_INF154_01618 Catalytic - R06915 rxn04724 2 Plasmid encoded is Pseudomonas putida.
3MTPCOAL 3-(methylthio)propanoate CoA ligase atp_c + mtpp_c + coa_c + 4.0 h_c --> amp_c + ppi_c + mtppcoa_c 0 1000 KPN_01128 Catalytic - R10820 - 2 Evidence in marine bacteria.
3MXN3D 3-methylxanthine Methylxanthine N3-demethylase 3mxan_c + nadph_c + o2_c + h_c --> xan_c + nadp_c + fald_c + h2o_c 0 1000 Klebsiella_pneumoniae_KSB2_1B_04894 Catalytic - R07967 rxn07757 2 Protein evidence in bacteria and Pseudomonas putida. Degradation pathway.
3NTD2pp 3'-nucleotidase (UMP) (periplasm) 3ump_p + h2o_p --> pi_p + uri_p Nucleotide Salvage Pathway 0 1000 KPN_04607 Catalytic 3NTD2pp R07127; R01877 rxn04930; rxn01367 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3NTD2pp_1 3'-nucleotidase (UMP) (periplasm) 3dhguln_c + 3ump_p + atp_c + h2o_p --> 3dhgulnp_c + adp_c + h_c + pi_p + uri_p 0 1000 KPN_04607 Catalytic 3NTD2pp_1 - - 2 Evidence in E. coli.
3NTD4pp 3'-nucleotidase (CMP) (periplasm) 3cmp_p + h2o_p --> cytd_p + pi_p Nucleotide Salvage Pathway 0 1000 KPN_04607 Catalytic 3NTD4pp R02370 rxn01704 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3NTD7pp 3'-nucleotidase (AMP) (periplasm) 3amp_p + h2o_p --> adn_p + pi_p Nucleotide Salvage Pathway 0 1000 KPN_04607 Catalytic 3NTD7pp R01562 rxn01139 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3NTD9pp 3'-nucleotidase (GMP) (periplasm) 3gmp_p + h2o_p --> gsn_p + pi_p Nucleotide Salvage Pathway 0 1000 KPN_04607 Catalytic 3NTD9pp R02148 rxn01549 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3NTYROXDApp 3 Nitrotyramine oxygen oxidoreductase deaminating flavin containing periplasm 3ntym_p + h2o_p + o2_p --> 4h3npacald_p + h2o2_p + nh4_p 0 1000 KPN_01467 Catalytic 3NTYROXDApp - - 2 Implicated nitrogen source in Klebsiella (mouse model).
3OADPCOAT 3-oxoadipate CoA-transferase 3oxoadp_c + succoa_c --> oxadpcoa_c + succ_c Benzoate degradation 0 1000 KPN_01538 and KPN_01539 Catalytic 3OADPCOAT R02990 rxn02143 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAR100 3-oxoacyl-[acyl-carrier-protein] reductase (n-C10:0) 3odecACP_c + h_c + nadph_c <=> 3hdecACP_c + nadp_c -1000 1000 KPN_01091 or KPN_01694 or K_pneumoniae_SB617_05105 or Klebsiella_variicola_KSB2_3A_03791 or K_quasi_quasi_SB98_01279 or 16852_1_14_05088 or K_quasivariicola_08A119_03708 or 16852_1_20_00391 or KPN_00827 or KPN_00620 or KPN_03338 or K_variicola_variicola_F2R9T_02213 or Klebsiella_pneumoniae_INF144_03589 Catalytic 3OAR100 R04534 rxn05338 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAR120 3-oxoacyl-[acyl-carrier-protein] reductase (n-C12:0) 3oddecACP_c + h_c + nadph_c <=> 3hddecACP_c + nadp_c -1000 1000 KPN_01091 or KPN_01694 or K_pneumoniae_SB617_05105 or Klebsiella_variicola_KSB2_3A_03791 or K_quasi_quasi_SB98_01279 or 16852_1_14_05088 or K_quasivariicola_08A119_03708 or 16852_1_20_00391 or KPN_00827 or KPN_00620 or KPN_03338 or K_variicola_variicola_F2R9T_02213 or Klebsiella_pneumoniae_INF144_03589 Catalytic 3OAR120 R04964 rxn05340 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAR121 3-oxoacyl-[acyl-carrier-protein] reductase (n-C12:1) 3ocddec5eACP_c + h_c + nadph_c --> 3hcddec5eACP_c + nadp_c Cell Envelope Biosynthesis 0 1000 KPN_01091 Catalytic 3OAR121 - rxn07987 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAR140 3-oxoacyl-[acyl-carrier-protein] reductase (n-C14:0) 3omrsACP_c + h_c + nadph_c <=> 3hmrsACP_c + nadp_c -1000 1000 KPN_01091 or KPN_01694 or K_pneumoniae_SB617_05105 or Klebsiella_variicola_KSB2_3A_03791 or K_quasi_quasi_SB98_01279 or 16852_1_14_05088 or K_quasivariicola_08A119_03708 or 16852_1_20_00391 or KPN_00827 or KPN_00620 or KPN_03338 or K_variicola_variicola_F2R9T_02213 or Klebsiella_pneumoniae_INF144_03589 Catalytic 3OAR140 R04566 rxn05342 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAR141 3-oxoacyl-[acyl-carrier-protein] reductase (n-C14:1) 3ocmrs7eACP_c + h_c + nadph_c --> 3hcmrs7eACP_c + nadp_c Cell Envelope Biosynthesis 0 1000 KPN_01091 Catalytic 3OAR141 - rxn07989 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAR160 3-oxoacyl-[acyl-carrier-protein] reductase (n-C16:0) 3opalmACP_c + h_c + nadph_c <=> 3hpalmACP_c + nadp_c -1000 1000 KPN_01091 or KPN_01694 or K_pneumoniae_SB617_05105 or Klebsiella_variicola_KSB2_3A_03791 or K_quasi_quasi_SB98_01279 or 16852_1_14_05088 or K_quasivariicola_08A119_03708 or 16852_1_20_00391 or KPN_00827 or KPN_00620 or KPN_03338 or K_variicola_variicola_F2R9T_02213 or Klebsiella_pneumoniae_INF144_03589 Catalytic 3OAR160 R04543 rxn05336 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAR161 3-oxoacyl-[acyl-carrier-protein] reductase (n-C16:1) 3ocpalm9eACP_c + h_c + nadph_c --> 3hcpalm9eACP_c + nadp_c Cell Envelope Biosynthesis 0 1000 KPN_01091 Catalytic 3OAR161 - rxn07991 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAR180 3-oxoacyl-[acyl-carrier-protein] reductase (n-C18:0) 3ooctdACP_c + h_c + nadph_c <=> 3hoctaACP_c + nadp_c Cell Envelope Biosynthesis -1000 1000 KPN_01091 Catalytic 3OAR180 - rxn07992 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAR181 3-oxoacyl-[acyl-carrier-protein] reductase (n-C18:1) 3ocvac11eACP_c + h_c + nadph_c --> 3hcvac11eACP_c + nadp_c Cell Envelope Biosynthesis 0 1000 KPN_01091 Catalytic 3OAR181 - rxn07993 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAR40 3-oxoacyl-[acyl-carrier-protein] reductase (n-C4:0) actACP_c + h_c + nadph_c <=> 3haACP_c + nadp_c -1000 1000 KPN_01091 or KPN_01694 or K_pneumoniae_SB617_05105 or Klebsiella_variicola_KSB2_3A_03791 or K_quasi_quasi_SB98_01279 or 16852_1_14_05088 or K_quasivariicola_08A119_03708 or 16852_1_20_00391 or KPN_00827 or KPN_00620 or KPN_03338 or K_variicola_variicola_F2R9T_02213 or Klebsiella_pneumoniae_INF144_03589 Catalytic 3OAR40 R04533 rxn07994 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAR60 3-oxoacyl-[acyl-carrier-protein] reductase (n-C6:0) 3ohexACP_c + h_c + nadph_c <=> 3hhexACP_c + nadp_c -1000 1000 KPN_01091 or KPN_01694 or K_pneumoniae_SB617_05105 or Klebsiella_variicola_KSB2_3A_03791 or K_quasi_quasi_SB98_01279 or 16852_1_14_05088 or K_quasivariicola_08A119_03708 or 16852_1_20_00391 or KPN_00827 or KPN_00620 or KPN_03338 or K_variicola_variicola_F2R9T_02213 or Klebsiella_pneumoniae_INF144_03589 Catalytic 3OAR60 R04953 rxn05337 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAR80 3-oxoacyl-[acyl-carrier-protein] reductase (n-C8:0) 3ooctACP_c + h_c + nadph_c <=> 3hoctACP_c + nadp_c -1000 1000 KPN_01091 or KPN_01694 or K_pneumoniae_SB617_05105 or Klebsiella_variicola_KSB2_3A_03791 or K_quasi_quasi_SB98_01279 or 16852_1_14_05088 or K_quasivariicola_08A119_03708 or 16852_1_20_00391 or KPN_00827 or KPN_00620 or KPN_03338 or K_variicola_variicola_F2R9T_02213 or Klebsiella_pneumoniae_INF144_03589 Catalytic 3OAR80 R04536 rxn05341 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAS100 3-oxoacyl-[acyl-carrier-protein] synthase (n-C10:0) h_c + malACP_c + ocACP_c --> 3odecACP_c + ACP_c + co2_c 0 1000 KPN_01093 or KPN_02713 or K_pneumoniae_SB617_05107 or Klebsiella_pneumoniae_INF350_02403 Catalytic 3OAS100 R04960 rxn05343 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAS120 3-oxoacyl-[acyl-carrier-protein] synthase (n-C12:0) dcaACP_c + h_c + malACP_c --> 3oddecACP_c + ACP_c + co2_c 0 1000 KPN_01093 or KPN_02713 or K_pneumoniae_SB617_05107 or Klebsiella_pneumoniae_INF350_02403 Catalytic 3OAS120 R04963 rxn05348 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAS121 3-oxoacyl-[acyl-carrier-protein] synthase (n-C12:1) cdec3eACP_c + h_c + malACP_c --> 3ocddec5eACP_c + ACP_c + co2_c 0 1000 KPN_01093 or KPN_02713 or K_pneumoniae_SB617_05107 or Klebsiella_pneumoniae_INF350_02403 Catalytic 3OAS121 R02768 rxn07997 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAS140 3-oxoacyl-[acyl-carrier-protein] synthase (n-C14:0) cddec5eACP_c + h_c + malACP_c --> 3ocmrs7eACP_c + ACP_c + co2_c 0 1000 KPN_01093 or KPN_02713 or K_pneumoniae_SB617_05107 or Klebsiella_pneumoniae_INF350_02403 Catalytic 3OAS140 R04726 rxn05345 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAS141 3-oxoacyl-[acyl-carrier-protein] synthase (n-C14:1) cddec5eACP_c + h_c + malACP_c --> 3ocmrs7eACP_c + ACP_c + co2_c 0 1000 KPN_02713 or K_pneumoniae_SB617_05107 or Klebsiella_pneumoniae_INF350_02403 Catalytic 3OAS141 R02768 rxn07998 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAS160 3-oxoacyl-[acyl-carrier-protein] synthase (n-C16:0) h_c + malACP_c + myrsACP_c --> 3opalmACP_c + ACP_c + co2_c 0 1000 KPN_01093 or KPN_02713 or K_pneumoniae_SB617_05107 or Klebsiella_pneumoniae_INF350_02403 Catalytic 3OAS160 R02768 rxn25647 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAS161 3-oxoacyl-[acyl-carrier-protein] synthase (n-C16:1) h_c + malACP_c + tdeACP_c --> 3ocpalm9eACP_c + ACP_c + co2_c 0 1000 KPN_02713 or K_pneumoniae_SB617_05107 or Klebsiella_pneumoniae_INF350_02403 Catalytic 3OAS161 R02768 rxn08000 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAS180 3-oxoacyl-[acyl-carrier-protein] synthase (n-C18:0) h_c + malACP_c + palmACP_c --> 3ooctdACP_c + ACP_c + co2_c 0 1000 KPN_01093 or KPN_02713 or K_pneumoniae_SB617_05107 or Klebsiella_pneumoniae_INF350_02403 Catalytic 3OAS180 R02768 rxn08001 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAS181 3-oxoacyl-[acyl-carrier-protein] synthase (n-C18:1) h_c + hdeACP_c + malACP_c --> 3ocvac11eACP_c + ACP_c + co2_c 0 1000 KPN_01093 or KPN_02713 or Klebsiella_pneumoniae_INF350_02403 Catalytic 3OAS181 R02768 rxn08002 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAS60 3-oxoacyl-[acyl-carrier-protein] synthase (n-C6:0) butACP_c + h_c + malACP_c --> 3ohexACP_c + ACP_c + co2_c 0 1000 KPN_01093 or KPN_02713 or K_pneumoniae_SB617_05107 or Klebsiella_pneumoniae_INF350_02403 Catalytic 3OAS60 R04952 rxn05346 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OAS80 3-oxoacyl-[acyl-carrier-protein] synthase (n-C8:0) h_c + hexACP_c + malACP_c --> 3ooctACP_c + ACP_c + co2_c 0 1000 KPN_01093 or KPN_02713 or K_pneumoniae_SB617_05107 or Klebsiella_pneumoniae_INF350_02403 Catalytic 3OAS80 R04957 rxn05350 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3OXCOAT 3-oxoadipyl-CoA thiolase coa_c + oxadpcoa_c <=> accoa_c + succoa_c -1000 1000 KPN_03268 or KPN_01540 or KPN_02055 or KPN_01478 or 16870_8_36_00858 or KPN_04339 Catalytic 3OXCOAT R00829 rxn00598 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3PEPTabcpp Tripeptide (LalaDgluMdap) transport via ABC system (periplasm) LalaDgluMdap_p + atp_c + h2o_c --> LalaDgluMdap_c + adp_c + h_c + pi_c Murein Recycling 0 1000 KPN_02194 and KPN_02193 and KPN_01310 and KPN_02195 and KPN_02196 Transport 3PEPTabcpp - rxn08003 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3PEPTtex LalaDgluMdap (tripeptide) transport via diffusion (extracellular to periplasm) LalaDgluMdap_e <=> LalaDgluMdap_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport 3PEPTtex - rxn08004 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
3PGt6pp 3 Phospho D glycerate phosphate antiporter periplasm 3pg_p + pi_c --> 3pg_c + pi_p 0 1000 KPN_01724 Transport 3PGt6pp - rxn05479 2 Transport reaction for known Klebsiella growth substrate.
3PGtex 3 Phospho D glycerate transport via diffusion extracellular to periplasm 3pg_e <=> 3pg_p -1000 1000 KPN_00282 or KPN_00956 or KPN_01445 or KPN_02636 Transport 3PGtex - rxn08562 2 Transport reaction for known Klebsiella growth substrate.
3PHACTE Phenylacetyl CoA thioesterase 3hphaccoa_c + h2o_c --> 3hoxpac_c + coa_c + 4.0 h_c 0 1000 KPN_01477 Catalytic 3PHACTE - - 2 Structural evidence in S. pneumoniae and genomic evidence in Klebsiella.
3SLAR 3-sulfolactaldehyde reductase h_c + nadh_c + sla_c --> dhps_c + nad_c 0 1000 K_africana_200023T_04818 Catalytic 3SLAR - - 2 Catalytic protein is involved in isethionate biosynthesis. Evidence of the latter in K. oxytoca.
3UMPtex 3UMP transport via diffusion (extracellular to periplasm) 3ump_e <=> 3ump_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport 3UMPtex - rxn08005 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
41R1H2MAE12BOOX "4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)" adrnl_c + h2o_c + o2_c --> 34dhmald_c + h2o2_c + mma_c 0 1000 KPN_01467 Catalytic 41R1H2MAE12BOOX - - 2 Evidence of this protein (studied regulation) in K. aerogenes.
41R2A1H12BOOX_1 RXN-10907 h2o_c + h_p + nrpphr_c + o2_c --> 34dhmald_c + h2o2_c + h_c + nh4_c 0 1000 KPN_01467 Catalytic 41R2A1H12BOOX_1 - - 2 Evidence of this protein (studied regulation) in K. aerogenes.
42A12BOOX "4-(2-Aminoethyl)-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)" dopa_c + h2o_c + o2_c --> 34dhpac_c + h2o2_c + nh4_c 0 1000 KPN_01467 Catalytic 42A12BOOX R04300 rxn02993 2 Evidence of this protein (studied regulation) in K. aerogenes.
42A12BOOXpp 4-(2-Aminoethyl)-1_2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing) dopa_p + h2o_p + o2_p --> 34dhpac_p + h2o2_p + nh4_p 0 1000 KPN_01467 or (Klebsiella_pneumoniae_INF237_05053 and Klebsiella_pneumoniae_INF151_05411) Catalytic 42A12BOOXpp R04300 rxn02993 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
4ABUTD 4-Aminobutyraldehyde:NAD+ oxidoreductase 4abutn_c + h2o_c + nadp_c --> 4abut_c + 2.0 h_c + nadph_c 0 1000 16852_1_74_04792 Catalytic 4ABUTD R01986 rxn01459 2 Evidence in K. aerogenes.
4ABZGLUH P-aminobenzoyl-glutamate hydrolase 4abzglu_c + h2o_c <=> 4abz_c + glu__L_c -1000 1000 16703_5_15_01830 and KPN_01534 Catalytic 4ABZGLUH - - 4 Protein structure available for this reaction (Klebsiella). 3I01 sequence has 97% sequence identity and 100% coverage to KPN_01534.
4ABZGLUtex P-aminobenzoyl glutamate transport via diffusion (extracellular to periplasm) 4abzglu_e <=> 4abzglu_p -1000 1000 KPN_00282 or KPN_01445 or KPN_02636 Transport 4ABZGLUtex - - 4 Transport reaction for known Klebsiella growth substrate (with known Klebsiella protein structure).
4ABZGLUtr P-aminobenzoyl glutamate:H+ symporter 4abzglu_p + h_p <=> 4abzglu_c + h_c -1000 1000 KPN_01532 Transport 4ABZGLUtr - - 4 Transport reaction for known Klebsiella growth substrate (with known Klebsiella protein structure).
4C4H2OAL 4-carboxy-4-hydroxy-2-oxoadipate oxaloacetate-lyase (pyruvate-forming) 4c4h2oap_c --> oaa_c + pyr_c + 3.0 h_c 0 1000 16703_7_36_05039 or 16703_5_22_02128 or 16852_1_74_04795 or AUSMDU00003506_S45_L999_01098 or KPN_04048 or 16703_7_36_05040 Catalytic - R00350 rxn00255 2 Evidence in Psuedomonas putida.
4CATDOX 4-Methylcatechol Oxidoreductase (decyclizing) 4mcat_c + o2_c --> 3mccmuac_c 0 1000 KPN_01873 Catalytic - R05299 rxn03611 2 Evidence in Acinetobacter.
4CMBLH 4-carboxymethylenebut-2-en-4-olide lactonohydrolase 25dcmb2e4o_c + h2o_c --> 25d4oh2ed_c 0 1000 KPN_03421 or KPN_04326 or 16870_8_42_00192 Catalytic - R06835 rxn04650 4 KPN_04326 has 99.5% sequence identity to 3F67 protein structure. Evidence that bacteria can utilise these metabolites/reaction.
4CMLCL_kt 4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN 4cml_c + h_c --> 5odhf2a_c + co2_c + h_c 0 1000 KPN_01217 or Klebsiella_pneumoniae_INF079_05152 or AUSMDU00003500_S10_L001_04824 Catalytic 4CMLCL_kt R03470 rxn02483 2 Evidence in Acinetobacter.
4FBZOR "4-fluorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" 4fbz_c + nadh_c + h_c + o2_c --> 4fcl12d1c_c + nad_c 0 1000 KPN_01872 and KPN_01871 and KPN_01870 Catalytic - R08110 rxn07898 2 Evidence in Acinetobacter and literature suggesting Klebsiella can utilise this pathway.
4FBZt 4-fluorobenzoate transport (diffusion) 4fbz_e <=> 4fbz_c -1000 1000 KPN_SPONT Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
4FCCOR "4-fluorocatechol:oxygen 1,2-oxidoreductase" 4fcc_c + o2_c --> 3fccm_c 0 1000 KPN_01873 Catalytic - R08115 rxn07903 2 Evidence in Acinetobacter and literature suggesting Klebsiella can utilise this pathway.
4FMLH 4-fluoromuconolactone lactonohydrolase 4fml_c + h2o_c --> malac_c + f_c + 3.0 h_c 0 1000 KPN_03421 or KPN_04326 or 16870_8_42_00192 Catalytic - R08121 rxn07909 4 KPN_04326 has 99.5% sequence identity to 3F67 protein structure. Evidence that bacteria can utilise these metabolites/reaction.
4FMLL 4-fluoromuconolactone lyase (decyclizing) 3fccm_c --> 4fml_c 0 1000 KPN_01875 Catalytic - R08116 rxn07904 2 Evidence in Pseudomonas putida and literature suggesting Klebsiella can utilise this pathway.
4H2KPILY 4h2kpi Lyase 4h2kpi_c --> pyr_c + sucsal_c 0 1000 KPN_04783 or KPN_02650 or KPN_03538 Catalytic 4H2KPILY R01645 rxn01202 2 Part of the 4-hydroxyphenylacetate degradation pathway which Klebsiella is known to at least catabolise.
4H3NALDD Aldehyde dehydrogenase 4 hydroxy 3 nitrophenylacetaldehyde NAD 4h3npacald_c + h2o_c + nad_c --> 4h3npac_c + 2.0 h_c + nadh_c 0 1000 KPN_01455 Catalytic 4H3NALDD - - 2 Genomic evidence of protein in Klebsiella.
4H4M2OPYL 4-hydroxy-4-methyl-2-oxoglutarate Pyruvate-Lyase (pyruvate-forming) parapyr_c --> 2.0 pyr_c + 2.0 h_c 0 1000 16703_7_36_05039 or 16703_5_22_02128 or 16852_1_74_04795 or AUSMDU00003506_S45_L999_01098 or KPN_04048 or 16703_7_36_05040 Catalytic - R00008 rxn00004 2 Evidence in Psuedomonas putida.
4HALDD Aldehyde dehydrogenase 4 hydroxyphenylacetaldehyde NAD 4hoxpacd_c + h2o_c + nad_c --> 4hphac_c + 2.0 h_c + nadh_c 0 1000 KPN_01455 Catalytic 4HALDD - - 2 Genomic evidence of protein in Klebsiella.
4HBFCL 4-Hydroxybenzoylformate carboxy-lyase 4hpg_c --> 4hbald_c + co2_c 0 1000 16852_1_18_00212 or K_variicola_variicola_F2R9T_01295 Catalytic - R02672 rxn01933 2 Evidence in pseudomonas.
4HBHYOX 4 hydroxybenzoate NADPHoxygen oxidoreductase 3 hydroxylating 4hbz_c + h_c + nadph_c + o2_c --> h2o_c + nadp_c + 34dhbz_c 0 1000 KPN_04815 Catalytic 4HBHYOX R01298 rxn00962 4 Evidence that Klebsiella can utilise this substrate but not as a core gene as ability to utilise this substrate is the transport reaction (https://modelseed.org/biochem/compounds/cpd00136).
4HBZCL 4-hydroxybenzoate carboxy-lyase (phenol-forming) 4hbz_c + h_c <-- phenol_c + co2_c -1000 0 Klebsiella_pneumoniae_kppr1.contigset_01001 or KPN_02701 or 16703_7_12_04900 Catalytic - R01238 rxn00921 2 Evidence in Bacillus and E. coli.
4HBZt3pp 4-hydroxybenzoate transport out via antiporter 4hbz_c + h_p --> 4hbz_p + h_c 0 1000 KPN_03649 and KPN_03650 Transport 4HBZt3pp - - 2 Transport reaction for known Klebsiella growth substrate.
4HBZtex 4-Hydroxybenzoate transport (extracellular) 4hbz_e <=> 4hbz_p -1000 1000 - Transport - - - 2 Transport reaction for known Klebsiella growth substrate. No gene sequence associated with the reaction.
4HGLSD L 4 hydroxyglutamate semialdehyde dehydrogenase h2o_c + nad_c + 4hglusa_c <=> 2.0 h_c + nadh_c + e4hglu_c -1000 1000 KPN_01041 Catalytic - R05051 rxn03424 2 Evidence in E. coli.
4HMSCOR 4-Hydroxymethylsalicylate oxidoreductase 4hmsial_c + o2_c + nadh_c + h_c --> 3hmcat_c + nad_c + h2o_c + co2_c 0 1000 Klebsiella_variicola_INF154_01618 Catalytic - R06936 rxn04745 2 "Has more significant hit to K22270 but unknown if that hit is correct as it belongs to an ""unclear reaction"". Plasmid encoded is Pseudomonas putida."
4HOXPACDdeg 4-hydroxyphenylacetaldehyde degradation h2o_c + hoxpacd_c + nad_c --> 4hphac_c + 2.0 h_c + nadh_c Unassigned 0 1000 KPN_00535 Catalytic - - - 1 "transport reaction required so 4-hydroxyphenylacetaldehyde can be utilised as a substrate, mechanism unknown"
4HOXPACDtex 4-hydroxyphenylacetaldehyde transport via diffusion (extracellular to periplasm) 4hoxpacd_e <=> 4hoxpacd_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport 4HOXPACDtex - rxn08006 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
4HOXPACMOF 4 hydroxyphenylacetate 3 monooxygenase FADH2 4hphac_c + fadh2_c + o2_c --> 34dhpha_c + fad_c + h2o_c 0 1000 KPN_04780 Catalytic 4HOXPACMOF - - 2 Part of the 4-hydroxyphenylacetate degradation pathway which Klebsiella is known to at least catabolise.
4HOXPACMON 4 hydroxyphenylacetate 3 monooxygenase nadh 4hoxpac_c + nadh_c + o2_c --> 34dhpacet_c + h2o_c + nad_c 0 1000 KPN_04779 or KPN_04780 Catalytic 4HOXPACMON R02698 rxn01945 2 Part of the 4-hydroxyphenylacetate degradation pathway which Klebsiella is known to at least catabolise.
4HOXPACt2pp 4 hydroxyphenylacetate transport in via proton symport periplasm 4hphac_p + h_p --> 4hphac_c + h_c 0 1000 HMPHIOOD_04460 or KPN_02651 or KPN_01586 or KPN_04782 Transport 4HOXPACt2pp - - 2 Transport reaction to complete the pathway from v1.
4HOXPACt2pp_1 4 hydroxyphenylacetate transport in via proton symport periplasm 4hoxpac_p + h_p --> 4hoxpac_c + h_c 0 1000 HMPHIOOD_04460 or KPN_04782 Transport 4HOXPACt2pp_1 - rxn10559 2 Transport reaction for known Klebsiella growth substrate.
4hoxpactex 4 hydroxyphenylacetate transport via diffusion extracellular to periplasm 4hoxpac_e <=> 4hoxpac_p -1000 1000 KPN_00282 or KPN_00956 or KPN_01445 or KPN_02636 Transport 4hoxpactex - - 2 Transport reaction for known Klebsiella growth substrate.
4HPAO 4-hydroxyphenylacetaldehyde oxidoreductase 4hoxpacd_c + nad_c + h2o_c <=> 4hphac_c + nadh_c + 2.0 h_c -1000 1000 16852_1_74_04792 or KPN_01455 Catalytic - R02695 rxn01943 2 Evidence in E. coli.
4HPAOX HPA monooxygenase 4hoxpac_c + nadh_c + o2_c --> 34dhpha_c + h2o_c + nad_c 0 1000 KPN_04779 and KPN_04780 Catalytic 4HPAOX - - 2 Catalytic reaction for known Klebsiella growth substrate.
4HPAtpp HPA permease 4hoxpac_p --> 4hoxpac_c 0 1000 HMPHIOOD_04460 or KPN_04782 Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
4HPEOX 4-Hydroxyphenylethanol oxidoreductase 4hpe_c + nad_c --> 4hpaa_c + nadh_c + h_c 0 1000 Klebsiella_variicola_KSB2_3A_05265 or KPN_01945 Catalytic - R04304 rxn02996 2 Evidence in P. putida. Tyrosol is an antioxidant and has potential antimicrobial properties.
4HPRO_LT_Et Trans-4-Hydroxy-L-proline transport (transport mechanism unknown - evidence from biolog data) 4hpro_LT_e <=> 4hpro_LT_c -1000 1000 - Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
4HPROE 4 hydroxyproline epimerase 4hpro_LT_c <=> 4hpro_DC_c -1000 1000 Klebsiella_variicola_KSB1_8J_04326 Catalytic - R03296 rxn02360 2 "Evidence in bacterial and nosocomial pathogens (Pseudomonas aeruginosa, Burkholderia pseudomallei and 3 Brucella). Kp can grow on hydroxyproline."
4HTDHDPS 4-hydroxy-tetrahydrodipicolinate synthase aspsa_c + pyr_c --> hpta_c + h2o_c 0 1000 Klebsiella_pneumoniae_INF144_02506 or KPN_02812 or Klebsiella_variicola_INF022_05217 Catalytic - R10147 rxn40037 2 Evidence in E. coli.
4HTHRA 4-hydroxy-L-threonine aldolase 4hthr_c <=> gcald_c + gly_c -1000 1000 KPN_00903 Catalytic 4HTHRA - - 2 Catalytic reaction for substrate that can be simulated by the model. Evidence of catalytic protein in E. coli.
4HTHRK 4-Hydroxy-L-threonine kinase 4hthr_c + atp_c --> adp_c + h_c + phthr_c 0 1000 KPN_00003 Catalytic 4HTHRK - rxn26436 2 Catalytic reaction for substrate that can be simulated by the model. Evidence of catalytic protein in E. coli.
4HTHRS 4-Hydroxy-L-threonine synthase h2o_c + phthr_c --> 4hthr_c + pi_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_00004 Catalytic 4HTHRS R05086 rxn03446 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
4HTHRtex 4-hydroxy-L-threonine transport 4hthr_e <=> 4hthr_p -1000 1000 KPN_00282 or KPN_00956 or KPN_01445 or KPN_02636 Transport 4HTHRtex - - 2 Transport reaction for substrate that can be simulated by the model.
4HTHRtrpp 4-hydroxy-L-threonine transport h_p + 4hthr_p <=> 4hthr_c + h_c -1000 1000 KPN_02294 Transport 4HTHRtrpp - - 2 Transport reaction for substrate that can be simulated by the model.
4M3OPAO 4-methyl-3-oxo-pentanoyl-ACP NADP oxidoreductase h_c + nadph_c + 4m3opACP_c <=> nadp_c + 4m3hpAPC_c -1000 1000 KPN_01694 Catalytic 4M3OPAO - rxn05410 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
4M3OXHA 4-methyl-3-oxo-hexanoyl-ACP NADP oxidoreductase h_c + nadph_c + 4m3ohexACP_c <=> nadp_c + 4m3hhexACP_c -1000 1000 KPN_01694 Catalytic 4M3OXHA - rxn05360 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
4MBZALDH Benzyl alcohol dehydrogenase nad_c + 4mbzalc_c --> h_c + nadh_c + 4mbzald_c 0 1000 Klebsiella_variicola_KSB2_3A_05265 or KPN_01945 Catalytic 4MBZALDH R05282 rxn03594 2 Evidence of being plasmid-encoded in Pseudomonas.
4MSCOR 4-Methylsalicylate oxidoreductase 4msial_c + o2_c + nadh_c + h_c --> 4mcat_c + nad_c + h2o_c + co2_c 0 1000 Klebsiella_variicola_INF154_01618 Catalytic - R06939 rxn04748 2 "Has more significant hit to K22270 but unknown if that hit is correct as it belongs to an ""unclear reaction"". Plasmid encoded is Pseudomonas putida."
4MUCCUCI 4-Methylmuconolactone lyase (decyclizing) 3mccmuac_c --> 4mmucl_c 0 1000 KPN_01875 Catalytic - R05300 rxn03612 2 Evidence in P. putida.
4OD 4 oxalocrotonate decarboxylase h_c + oxalc_c --> co2_c + op4en_c 0 1000 Klebsiella_pneumoniae_INF161_04889 Catalytic 4OD R02602 rxn01894 2 Evidence in Pseudomonas. Part of a 15 gene operon but each gene encodes a singular enzyme.
4OD_1 4.1.1.77-RXN 2hmc_c + h_c --> co2_c + op4en_c 0 1000 KPN_02119 or KPN_04784 Catalytic 4OD_1 - - 2 Evidence in Pseudomonas. Part of a 15 gene operon but each gene encodes a singular enzyme.
4OD2 4 oxalocrotonate decarboxylase p xylene h_c + 2omcm_c --> co2_c + 2hchd_c 0 1000 Klebsiella_pneumoniae_INF161_04889 Catalytic 4OD2 R05374 rxn03675 2 Evidence in Pseudomonas.
4OT 4 oxalocrotonate tautomerase 2hmc_c <=> oxalc_c -1000 1000 KPN_02049 or KPN_01895 or K_pneumoniae_SB617_01375 or Klebsiella_pneumoniae_INF161_04891 Catalytic 4OT R03966 rxn02788 2 Main evidence of this reaction is in Pseudomonas putida.
4OT2 4 oxalocrotonate tautomerase pXylene hmccm_c <=> 2omcm_c -1000 1000 KPN_02049 or KPN_01895 or K_pneumoniae_SB617_01375 or Klebsiella_pneumoniae_INF161_04891 Catalytic 4OT2 R05389 rxn03690 2 Main evidence of this reaction is in Pseudomonas putida.
4PCP "Tetrapeptide L,D-carboxypeptidase" LalaDgluMdapDala_c + h2o_c --> LalaDgluMdap_c + ala__D_c Murein Recycling 0 1000 KPN_02306 Catalytic 4PCP - rxn08007 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
4PCPpp Tetrapeptide L_D-carboxypeptidase (periplasm) LalaDgluMdapDala_p + h2o_p --> LalaDgluMdap_p + ala__D_p 0 1000 KPN_02608 Catalytic 4PCPpp - rxn08007 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information. No gene-protein-rule previously associated with this reaction.
4PEPTabcpp Tetrapeptide (LalaDgluMdapDala) transport via ABC system (periplasm) LalaDgluMdapDala_p + atp_c + h2o_c --> LalaDgluMdapDala_c + adp_c + h_c + pi_c Murein Recycling 0 1000 KPN_02194 and KPN_02197 and KPN_02193 and KPN_02195 and KPN_02196 Transport 4PEPTabcpp - rxn08008 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
4PEPTtex LalaDgluMdapDala (pentapeptide) transport via diffusion (extracellular to periplasm) LalaDgluMdapDala_e <=> LalaDgluMdapDala_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport 4PEPTtex - rxn08009 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
4PHACTE Phenylacetyl CoA thioesterase h2o_c + hphaccoa_c --> 4hphac_c + coa_c + 5.0 h_c 0 1000 KPN_01477 Catalytic 4PHACTE - - 2 Structural evidence in S. pneumoniae and genomic evidence in Klebsiella.
4PHACTE_1 Phenylacetyl CoA thioesterase h2o_c + hphaccoa_c --> 4hoxpac_c + coa_c + 4.0 h_c 0 1000 KPN_01477 Catalytic 4PHACTE_1 - - 2 Structural evidence in S. pneumoniae and genomic evidence in Klebsiella.
5APOXR 5-aminopentanal Oxidoreductase 5ap_c + nad_c + h2o_c --> 5aptn_c + nadh_c + h_c 0 1000 KPN_01924 Catalytic - R12215 - 2 Evidence in E. coli.
5APTNabcpp D amino valeric acid transport via ABC system periplasm atp_c + h2o_c + 5aptn_p --> adp_c + h_c + pi_c + 5aptn_c 0 1000 KPN_03819 and KPN_03816 and KPN_03822 and KPN_03817 and KPN_03818 Transport 5APTNabcpp - - 2 Know some Klebs can utilise this substrate. Required the Liv operon for transport which is already encoded in the model (eg: ALAabcpp). However compared sequences to the Pseudomonas gene-protein-rule that encoded this reaction to see if same gene-protein-rule was reasonable. With sequence identities of 60-70% using the Liv operon from Klebsiella is sutiable.
5APTNtex D amino valeric acid transport via diffusion extracellular to periplasm 5aptn_e <=> 5aptn_p -1000 1000 - Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
5DGLCNR 5-dehydro-D-gluconate reductase 5dglcn_c + h_c + nadph_c --> glcn_c + nadp_c Alternate Carbon Metabolism 0 1000 HMPHIOOD_04334 or ICMGGLHG_01647 Catalytic 5DGLCNR R01740 rxn01278 2 "strain can use this compound, gene is 78% homologous to idnO from E. coli"
5DGLCNt2rpp "5-Dehydro-D-gluconate transport via proton symport, reversible (periplasm)" 5dglcn_p + h_p <=> 5dglcn_c + h_c "Transport, Inner Membrane" -1000 1000 KPN_03785 Catalytic 5DGLCNt2rpp - rxn08011 2 "Kqv, Kvv and Kvt can use this compound, this gene is 63% homologous to transport gene idnT in E. coli"
5DGLCNtex 5-Dehydro-D-gluconate transport via diffusion (extracellular to periplasm) 5dglcn_e <=> 5dglcn_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport 5DGLCNtex - rxn08012 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
5DKGR 5-keto-D-gluconate 5-reductase glcn_c + nad_c <=> 5dglcn_c + h_c + nadh_c -1000 1000 HMPHIOOD_04334 Catalytic 5DKGR - - 2 Evidence that K. variicola can utilise 5-keto-D-gluconic acid.
5DOAN 5'-deoxyadenosine nuclosidase dad_5_c + h2o_c --> 5drib_c + ade_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_00174 Catalytic 5DOAN - rxn08013; rxn13649 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
5FMLH 5-fluoromuconolactone lactonohydrolase 5fml_c + h2o_c --> malac_c + f_c + 3.0 h_c 0 1000 KPN_03421 or KPN_04326 or 16870_8_42_00192 Catalytic - R08120 rxn07908 4 KPN_04326 has 99.5% sequence identity to 3F67 protein structure. Evidence that bacteria can utilise these metabolites/reaction.
5HOXINOXDA_1 RXN-10778 h2o_c + h_p + o2_c + srtn_c --> 5hoxindact_c + h2o2_c + h_c + nh4_c 0 1000 KPN_01467 Catalytic 5HOXINOXDA_1 - - 2 Evidence of this protein (studied regulation) in K. aerogenes.
5MET3OH 5-methyl-3-oxo-hexanoyl-ACP NADP oxidoreductase h_c + nadph_c + 5m3hhACP_c <=> nadp_c + 5m3hACP_c -1000 1000 KPN_01694 Catalytic 5MET3OH - rxn05385 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
5MTRtex 5-Methylthio-D-ribose transport via proton diffusion (extracellular to periplasm) 5mtr_e <=> 5mtr_p -1000 1000 KPN_01445 or KPN_02636 or KPN_00282 Transport 5MTRtex - rxn29189 2 Transport reaction for substrate that can be simulated by the model.
5MTRtpp 5-Methylthio-D-ribose transport via proton symport (periplasm) 5mtr_c + h_c --> 5mtr_p + h_p 0 1000 - Transport - - - 1 Transport reaction for substrate that can be simulated by the model.
5OXPROabcpp L oxoproline transport via ABC system atp_c + h2o_c + 5oxpro_p --> adp_c + h_c + pi_c + 5oxpro_c -1000 1000 - Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
5OXPROtex L oxoproline transport via diffusion extracellular 5oxpro_e <=> 5oxpro_p -1000 1000 - Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
6D6SFK 6-deoxy-6-sulfofructose kinase atp_c + sf_c --> adp_c + h_c + sfp_c 0 1000 K_africana_200023T_04817 Catalytic 6D6SFK - - 2 Also known as Sulfoquinovose. Evidence in of sulfur utilisation in Klebsiella.
6D6SPA 6-deoxy-6-sulfofructose-1-phosphate aldolase sfp_c --> dhap_c + sla_c 0 1000 K_africana_200023T_04819 Catalytic 6D6SPA - - 2 Also known as Sulfoquinovose. Evidence in of sulfur utilisation in Klebsiella.
6M3OHAO 6-methyl-3-oxo-heptanoyl-ACP NADP oxidoreductase h_c + nadph_c + 6m3ohACP_c <=> nadp_c + 6m3hhACP_c -1000 1000 KPN_01694 Catalytic 6M3OHAO - rxn05414 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
6M3OXO 6-methyl-3-oxo-octanoyl-ACP NADP oxidoreductase h_c + nadph_c + 6m3oACP_c <=> nadp_c + 6m3hoACP_c -1000 1000 KPN_01694 Catalytic 6M3OXO - rxn05364 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
6PHBG 6-phospho-beta-glucosidase h2o_c + salcn6p_c --> 2hymeph_c + g6p_c 0 1000 KPN_02822 or Klebsiella_quasipneumoniae_INF291_04801 or KPN_01304 or 16870_8_26_05194 or KPN_04649 or KPN_01234 or KPN_04016 or KPN_03330 Catalytic 6PHBG R05134 rxn03482 4 "Evidence of protein in Kp and that these metabolites can be utilised. OR statement. KPN_03330 is already in the model, although there's less evidence of this particular gene in Kp. Only evidence of celF i Kp rather than bglA."
7M3O6CCAT 7-methyl-3-oxo-6-octenoyl-CoA C-acyltransferase 7m3o7ncoa_c + coa_c --> 5mh4ecoa_c + accoa_c 0 1000 KPN_01540 or 16870_8_36_00858 or KPN_01478 Catalytic - R08091 rxn07880 2 Evidence in E. coli.
7M3ODO 7-methyl-3-oxo-octanoyl-ACP NADP oxidoreductase h_c + nadph_c + 7me3oxoacp_c <=> nadp_c + 7m3hoACP_c -1000 1000 KPN_01694 Catalytic 7M3ODO - rxn05389 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
8M3OAO 8-methyl-3-oxo-decanoyl-ACP NADP oxidoreductase h_c + nadph_c + 8m3odACP_c <=> nadp_c + 8m3hdACP_c -1000 1000 KPN_01694 Catalytic 8M3OAO - rxn05368 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
8M3ONO 8-methyl-3-oxo-nonanoyl-ACP NADP oxidoreductase h_c + nadph_c + 8m3oxACP_c <=> nadp_c + 8m3hnACP_c -1000 1000 KPN_01694 Catalytic 8M3ONO - rxn05418 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
9M3OXPA 9-methyl-3-oxo-decanoyl-ACP NADP oxidoreductase h_c + nadph_c + 9m3odACP_c <=> nadp_c + 9m3hdACP_c -1000 1000 KPN_01694 Catalytic 9M3OXPA - rxn05393 4 Klebsiella structure available for fabG_2 (6T6P) and has 32% Seq identity to Klebsiella_pneumoniae_KSB2_1C_04035. Corresponding KO is K00059 which this sequence has a bit score of 254.9/273.47. Structure corresponds to KPN_01694 in the pangenome dataset (N=399) which has a significant hit to K00059. Therefore iKp1289 wasn't used for this gene-protein-rule and replaced with the sequence from the K. pneumoniae structure.
A5PISO Arabinose-5-phosphate isomerase ru5p__D_c <=> ara5p_c -1000 1000 KPN_03043 or KPN_03607 or K_pneumoniae_SB611_04672 Catalytic A5PISO R01530 rxn01117 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AAC24DABA N acetyl diamonbutyric acid acylase h2o_c + aac24dab_c --> ac_c + h_c + 24dab_c 0 1000 Klebsiella_variicola_KSB2_3A_04625 Catalytic - R09801 rxn16642 2 Evidence in E. coli.
AACPS1 Acyl-[acyl-carrier-protein] synthetase (n-C14:0) ACP_c + atp_c + ttdca_c --> amp_c + myrsACP_c + ppi_c Cell Envelope Biosynthesis 0 1000 KPN_01092 and KPN_03245 Catalytic AACPS1 - rxn08014 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AACPS2 Acyl-[acyl-carrier-protein] synthetase (n-C14:1) ACP_c + atp_c + ttdcea_c --> amp_c + ppi_c + tdeACP_c Cell Envelope Biosynthesis 0 1000 KPN_01092 and KPN_03245 Catalytic AACPS2 - rxn08015 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AACPS3 Acyl-[acyl-carrier-protein] synthetase (n-C16:0) ACP_c + atp_c + hdca_c --> amp_c + palmACP_c + ppi_c Cell Envelope Biosynthesis 0 1000 KPN_01092 and KPN_03245 Catalytic AACPS3 - rxn08016 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AACPS4 Acyl-[acyl-carrier-protein] synthetase (n-C16:1) ACP_c + atp_c + hdcea_c --> amp_c + hdeACP_c + ppi_c Cell Envelope Biosynthesis 0 1000 KPN_01092 and KPN_03245 Catalytic AACPS4 - rxn08017 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AACPS5 Acyl-[acyl-carrier-protein] synthetase (n-C18:1) ACP_c + atp_c + ocdcea_c --> amp_c + octeACP_c + ppi_c Cell Envelope Biosynthesis 0 1000 KPN_01092 and KPN_03245 Catalytic AACPS5 - rxn08018 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AACPS6 Acyl-[acyl-carrier-protein] synthetase (n-C18:0) ACP_c + atp_c + ocdca_c --> amp_c + ocdcaACP_c + ppi_c Cell Envelope Biosynthesis 0 1000 KPN_01092 and KPN_03245 Catalytic AACPS6 - rxn08019 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AACPS7 Acyl-[acyl-carrier-protein] synthetase (n-C12:0) ACP_c + atp_c + ddca_c --> amp_c + ddcaACP_c + ppi_c Cell Envelope Biosynthesis 0 1000 KPN_01092 and KPN_03245 Catalytic AACPS7 - rxn08020 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AACPS8 Acyl-[acyl-carrier-protein] synthetase (n-C10:0) ACP_c + atp_c + dca_c --> amp_c + dcaACP_c + ppi_c Cell Envelope Biosynthesis 0 1000 KPN_01092 and KPN_03245 Catalytic AACPS8 - rxn08021 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AACPS9 Acyl-[acyl-carrier-protein] synthetase (n-C8:0) ACP_c + atp_c + octa_c --> amp_c + ocACP_c + ppi_c Cell Envelope Biosynthesis 0 1000 KPN_01092 and KPN_03245 Catalytic AACPS9 - rxn08022 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AACTOOR Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing) aact_c + h2o_c + o2_c --> h2o2_c + mthgxl_c + nh4_c 0 1000 KPN_01467 Catalytic AACTOOR R02529 rxn01833 2 Bacterial protein structure exists and transport reactions already in model (v1).
AADa Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1 coa_c + aad_c <=> accoa_c + amp_c + 2.0 h_c -1000 1000 KPN_04478 Catalytic - R00236 rxn00176 2 Originally known as r0068 with evidence in E. coli.
AADb Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1 ac_c + atp_c + 2.0 h_c <=> ppi_c + aad_c -1000 1000 KPN_04478 Catalytic - R00316 rxn00226 2 Originally known as r0068 with evidence in E. coli.
AADDGT "DTDP-N-4-acetamido-4,6-dideoxy-D-galactose transferase" dtdp4aaddg_c + unagamu_c --> dtdp_c + h_c + unagamuf_c Cell Envelope Biosynthesis 0 1000 KPN_04294 Catalytic AADDGT - rxn08023 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AAHL Acrylamide hydro-lyase an_c + h2o_c --> aa_c 0 1000 Klebsiella_variicola_KSB2_3A_02578 and Klebsiella_variicola_KSB2_3A_02579 Catalytic - R05379 rxn03680 2 Reaction involved with known Klebsiella growth source.
AAMYL Alpha-amylase 14glucan_c --> malthx_c Alternate Carbon Metabolism 0 1000 KPN_02419 Catalytic AAMYL - rxn09952 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AAMYLpp Alpha-amylase (periplasm) 14glucan_p --> malthx_p Alternate Carbon Metabolism 0 1000 KPN_03935 Catalytic AAMYLpp - rxn08024 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AATA 2 aminoadipate transaminase glu__L_c + 2oxoadp_c <=> akg_c + L2aadp_c -1000 1000 AH0360_C4PNMANXX_GTAGAGGA-AAGGAGTA_L006_00537 or KPN_03415 Catalytic AATA R01939 rxn01423 2 Original evidence in T. thermophilus (lysN). Both sequences contain the same functional domain (PF00155.21).
AB6PGH Arbutin 6-phosphate glucohydrolase arbt6p_c + h2o_c --> g6p_c + hqn_c Alternate Carbon Metabolism 0 1000 KPN_03330 Catalytic AB6PGH - rxn08025 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ABTA 4-aminobutyrate transaminase 4abut_c + akg_c --> glu__L_c + sucsal_c 0 1000 KPN_00255 or KPN_03825 or 16852_1_74_04800 Catalytic ABTA R01648 rxn01204 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ABTDG D-arabitol dehydrogenase abt__D_c + nad_c <=> h_c + nadh_c + xylu__D_c Pentose and Glucuronate Interconversions -1000 1000 KPN_02543 Catalytic ABTDG R05604 rxn03883 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ABTpp2 D-arabinitol transport in via proton symporter abt__D_e + h_e --> abt__D_c + h_c Pentose and Glucuronate Interconversions 0 1000 KPN_02541 Transport ABTpp2 - rxn12551 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ABUTD Aminobutyraldehyde dehydrogenase 4abutn_c + h2o_c + nad_c --> 4abut_c + 2.0 h_c + nadh_c 0 1000 KPN_01924 or 16852_1_74_04792 Catalytic ABUTD R02549 rxn01851 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ABUTt2pp 4-aminobutyrate transport in via proton symport (periplasm) 4abut_p + h_p --> 4abut_c + h_c "Transport, Inner Membrane" 0 1000 KPN_00254 Transport ABUTt2pp - rxn05564 rxn08027 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ABUTtex 4-aminobutyrate transport via diffusion (extracellular to periplasm) 4abut_e <=> 4abut_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ABUTtex - rxn08028; rxn09795; rxn11326 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACACCT Acetyl-CoA:acetoacetyl-CoA transferase acac_c + accoa_c --> aacoa_c + ac_c 0 1000 ((Klebsiella_pneumoniae_KSB2_1C_01466 or K_africana_200023T_02422) and (Klebsiella_pneumoniae_kppr1.contigset_00309 or K_africana_200023T_02421)) Catalytic ACACCT R01359 rxn00990 2 Evidence in E. coli.
ACACT10 3-ketoacyl-CoA thiolase 3oddcoa_c + coa_c --> accoa_c + dcacoa_c 0 1000 KPN_02724 or KPN_04339 Catalytic ACACT10 - - 2 The catalytic protein (fadA) in Klebsiella (gene KO) and has been shown to help promote host tolerance to pulmonary infections.
ACACT11 3-ketoacyl-CoA thiolase 3ohcoa_c + coa_c --> accoa_c + btcoa_c 0 1000 KPN_04339 or KPN_02724 Catalytic ACACT11 - - 2 The catalytic protein (fadA) in Klebsiella (gene KO) and has been shown to help promote host tolerance to pulmonary infections.
ACACT12 3-ketoacyl-CoA thiolase 3ohdcoa_c + coa_c --> accoa_c + tdcoa_c 0 1000 KPN_04339 or KPN_02724 Catalytic ACACT12 - - 2 The catalytic protein (fadA) in Klebsiella (gene KO) and has been shown to help promote host tolerance to pulmonary infections.
ACACT13 3-ketoacyl-CoA thiolase 3odcoa_c + coa_c --> accoa_c + occoa_c 0 1000 KPN_02724 or KPN_04339 Catalytic ACACT13 - - 2 The catalytic protein (fadA) in Klebsiella (gene KO) and has been shown to help promote host tolerance to pulmonary infections.
ACACT1r Acetyl-CoA C-acetyltransferase 2.0 accoa_c <=> aacoa_c + coa_c Fatty Acid Biosynthesis -1000 1000 KPN_03268 or KPN_01540 or KPN_02055 Catalytic ACACT1r R00238 rxn00178 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACACt2pp Acetoacetate transport via proton symport (periplasm) acac_p + h_p <=> acac_c + h_c -1000 1000 16870_8_36_02669 Transport ACACt2pp - rxn05484 2 Transport reaction to complete the pathway from v1.
ACACT2r Acetyl-CoA C-acyltransferase (butanoyl-CoA) (r) accoa_c + btcoa_c <-- 3ohcoa_c + coa_c 0 1000 KPN_04339 or KPN_02724 or KPN_01540 or 16870_8_36_00858 or KPN_01478 Catalytic ACACT2r R01177 rxn00874 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACACT3r Acetyl-CoA C-acyltransferase (hexanoyl-CoA) (r) accoa_c + hxcoa_c <-- 3oocoa_c + coa_c 0 1000 KPN_04339 or KPN_02724 or KPN_01540 or 16870_8_36_00858 or KPN_01478 Catalytic ACACT3r R04747 rxn03248 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACACT4r Acetyl-CoA C-acyltransferase (octanoyl-CoA) (r) accoa_c + occoa_c <-- 3odcoa_c + coa_c 0 1000 KPN_04339 or KPN_02724 or KPN_01540 or 16870_8_36_00858 or KPN_01478 Catalytic ACACT4r R03778 rxn02680 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACACT5r Acetyl-CoA C-acyltransferase (decanoyl-CoA) (r) accoa_c + dcacoa_c <-- 3oddcoa_c + coa_c 0 1000 KPN_04339 or KPN_02724 or KPN_01540 or 16870_8_36_00858 or KPN_01478 Catalytic ACACT5r R04742 rxn03243 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACACT6r Acetyl-CoA C-acyltransferase (dodecanoyl-CoA) (r) accoa_c + ddcacoa_c <-- 3otdcoa_c + coa_c 0 1000 KPN_04339 or KPN_02724 or KPN_01540 or 16870_8_36_00858 or KPN_01478 Catalytic ACACT6r R03858 rxn06510 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACACT7r Acetyl-CoA C-acyltransferase (tetradecanoyl-CoA) (r) accoa_c + tdcoa_c <-- 3ohdcoa_c + coa_c 0 1000 KPN_04339 or KPN_02724 or KPN_01540 or 16870_8_36_00858 or KPN_01478 Catalytic ACACT7r R03991 rxn02804 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACACT8 3-ketoacyl-CoA thiolase 3oocoa_c + coa_c --> accoa_c + hxcoa_c 0 1000 KPN_02724 or KPN_04339 Catalytic ACACT8 - - 2 The catalytic protein (fadA) in Klebsiella (gene KO) and has been shown to help promote host tolerance to pulmonary infections.
ACACT8r "Acetyl-CoA acyltransferase (hexadecanoyl-CoA), (r)" 3ohodcoa_c + coa_c --> accoa_c + pmtcoa_c Membrane Lipid Metabolism 0 1000 KPN_04339 or KPN_02724 Catalytic ACACT8r - rxn08767 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACACT8r_copy1 Acetyl-CoA acyltransferase (hexadecanoyl-CoA) (r) 3ohodcoa_c + coa_c <=> accoa_c + pmtcoa_c -1000 1000 KPN_02724 or KPN_04339 Catalytic - - - 2 Part of acetotacetate degradation pathway in E. coli.
ACACT9 3-ketoacyl-CoA thiolase 3otdcoa_c + coa_c --> accoa_c + ddcacoa_c 0 1000 KPN_04339 or KPN_02724 Catalytic ACACT9 - - 2 The catalytic protein (fadA) in Klebsiella (gene KO) and has been shown to help promote host tolerance to pulmonary infections.
ACACtex Acetoacetate transport via diffusion (extracellular to periplasm) acac_e <=> acac_p -1000 1000 KPN_00282 or KPN_01445 or KPN_02636 Transport ACACtex - rxn08030 2 Transport reaction to complete the pathway from v1.
ACALD Acetaldehyde dehydrogenase (acetylating) acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c -1000 1000 KPN_02199 or KPN_02118 or 16852_1_36_02226 or KPN_02789 or Klebsiella_pneumoniae_INF161_04888 Catalytic ACALD R00228 rxn00171 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACALDtex Acetaldehyde transport via diffusion (extracellular to periplasm) acald_e <=> acald_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ACALDtex - rxn08032; rxn08033; rxn09700; rxn13212 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACALDtpp Acetaldehyde reversible transport (periplasm) acald_p <=> acald_c "Transport, Inner Membrane" -1000 1000 KPN_SPONT Transport ACALDtpp - rxn08032; rxn08033; rxn09700; rxn13212 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACANTHAT Acetyl-CoA:anthranilate acetyltransferase accoa_c + anth_c --> acanth_c + coa_c "Tyrosine, Tryptophan, and Phenylalanine Metabolism" 0 1000 KPN_01884 Catalytic ACANTHAT - rxn08034 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACBIPGT Adenosyl cobinamide phosphate guanyltransferase adocbip_c + gtp_c + h_c --> agdpcbi_c + ppi_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_03183 Catalytic ACBIPGT R05222 rxn03537 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACCOAC Acetyl-CoA carboxylase accoa_c + atp_c + hco3_c --> adp_c + h_c + malcoa_c + pi_c 0 1000 KPN_02706 and KPN_03665 and KPN_00198 and (KPN_03664 or Klebsiella_variicola_KSB2_3A_04151) Catalytic ACCOAC R00742 rxn00533 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACCOAL Acetate-CoA ligase (ADP-forming) atp_c + coa_c + ppa_c --> adp_c + pi_c + ppcoa_c 0 1000 KPN_04478 or Klebsiella_pneumoniae_INF079_05200 Catalytic ACCOAL R00920 rxn00669 2 Evidence in E. coli.
ACGAL1Ptex N-acetyl-D-galactosamine 1-phosphate transport via diffusion (extracellular to periplasm) acgal1p_e <=> acgal1p_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ACGAL1Ptex - rxn08036 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACGALptspp N-Acetyl-D-galactosamine transport via PEP:Pyr PTS (periplasm) acgal_p + pep_c + 2.0 h_c --> acgal6p_c + pyr_c 0 1000 Klebsiella_pneumoniae_INF151_05609 and Klebsiella_pneumoniae_INF151_05610 and Klebsiella_pneumoniae_INF151_05611 and Klebsiella_pneumoniae_INF151_05612 and Klebsiella_pneumoniae_INF151_05613 Transport ACGALptspp - - 2 Transport reaction to complete the pathway from v1.
ACGALtex N-acetyl-D-galactosamine transport via diffusion (extracellular to periplasm) acgal_e <=> acgal_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ACGALtex - rxn08037 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACGAM1PPpp N-acetyl-D-glucosamine 1-phosphatase (periplasm) acgam1p_p + h2o_p --> acgam_p + pi_p 0 1000 KPN_04180 Catalytic ACGAM1PPpp - rxn08038 2 Main metabolite known to be involved into the bacterial cell wall and Klebsiella biofilm production.
ACGAM1Ptex N-acetyl-D-glucosamine 1-phosphate transport via diffusion (extracellular to periplasm) acgam1p_e <=> acgam1p_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ACGAM1Ptex - rxn08039 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACGAMK N-acetylglucosamine kinase acgam_c + atp_c --> acgam6p_c + adp_c + h_c Murein Recycling 0 1000 KPN_01116 Catalytic ACGAMK R01201 rxn00892 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACGAMT UDP-N-acetylglucosamine:undecaprenylphosphate N-acetylglucosamine -1-phosphate transferase uacgam_c + udcpp_c --> ump_c + unaga_c Cell Envelope Biosynthesis 0 1000 KPN_04284 Catalytic ACGAMT R08856 rxn08040 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACGAptspp N-Acetyl-D-glucosamine transport via PEP:Pyr PTS (periplasm) acgam_p + pep_c --> acgam6p_c + pyr_c "Transport, Inner Membrane" 0 1000 (KPN_02764 and KPN_01099 and KPN_02763 and KPN_02762) or (KPN_00700 and KPN_02763 and KPN_02762) Transport ACGAptspp - rxn05485; rxn08041 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACGAtex N-Acetyl-D-glucosamine transport via diffusion (extracellular to periplasm) acgam_e <=> acgam_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ACGAtex - rxn08042 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACGK Acetylglutamate kinase acglu_c + atp_c --> acg5p_c + adp_c Arginine and Proline Metabolism 0 1000 KPN_04248 Catalytic ACGK R02649 rxn01917 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACGS N-acetylglutamate synthase accoa_c + glu__L_c --> acglu_c + coa_c + h_c Arginine and Proline Metabolism 0 1000 KPN_03226 Catalytic ACGS R00259 rxn00192 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACHBS 2-aceto-2-hydroxybutanoate synthase 2obut_c + h_c + pyr_c --> 2ahbut_c + co2_c 0 1000 ((KPN_00082 or KPN_02060 or 16852_1_74_04794) and KPN_00083) or (KPN_04073 and (KPN_04074 or KPN_04267 or 16703_5_22_01698)) Catalytic ACHBS R08648 rxn08043 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACHMSSELCYSL "O-Acetylhomoserine succinate-lyase (adding cysteine), cytosol" achms_c + selcys_c --> ac_c + selcyst_c 0 1000 KPN_04233 Catalytic - R04945 rxn03382 2 Reaction involved with known Klebsiella growth source.
ACKr Acetate kinase ac_c + atp_c <=> actp_c + adp_c -1000 1000 KPN_02364 or KPN_02687 or KPN_02293 or KPN_03222 Catalytic ACKr R00315 rxn00225 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACLDC Acetolactate decarboxylase alac__S_c + h_c --> actn__R_c + co2_c Butanoate Metabolism 0 1000 KPN_02059 Catalytic ACLDC R02948 rxn15383 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACLPNAT Acetyl-CoA L-phenylalanine N-acetyltransferase accoa_c + phe__L_c <=> coa_c + nacphe__L_c -1000 1000 KPN_03806 or Klebsiella_pneumoniae_KSB2_1C_00314 Catalytic - R00693 rxn00492 2 Evidence in E. coli.
ACLS Acetolactate synthase h_c + 2.0 pyr_c --> alac__S_c + co2_c 0 1000 (KPN_04073 and (KPN_04074 or 16703_5_22_01698)) or (KPN_04268 and KPN_04267) or ((KPN_00082 or KPN_02060 or 16852_1_74_04794) and KPN_00083) Catalytic ACLS R00226 rxn15021 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACLS_a Acetolactate synthase h_c + pyr_c + thmpp_c --> co2_c + hethmpp_c "Valine, Leucine, and Isoleucine Metabolism" 0 1000 - Catalytic ACLS_a - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACM6PH N-acetylmuramate 6-phosphate hydrolase acmum6p_c + h2o_c --> acgam6p_c + lac__D_c 0 1000 KPN_04043 or Klebsiella_pneumoniae_INF237_05222 Catalytic ACM6PH R08555 rxn08044 2 Evidence in E. coli and transport reactions already in model (v1).
ACMAMUT UDP-N-acetyl-D-mannosaminuronic acid transferase uacmamu_c + unaga_c --> h_c + udp_c + unagamu_c Cell Envelope Biosynthesis 0 1000 KPN_04295 Catalytic ACMAMUT R04477 rxn08045 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACMANAptspp N-acetyl-D-mannosamine transport via PTS (periplasm) acmana_p + pep_c --> acmanap_c + pyr_c "Transport, Inner Membrane" 0 1000 KPN_02335 and KPN_02763 and KPN_02334 and KPN_02333 and KPN_02762 Transport ACMANAptspp - rxn08046; rxn10183 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACMANAtex N-acetyl-D-mannosamine transport via diffusion (extracellular to periplasm) acmana_e <=> acmana_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ACMANAtex - rxn08047 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACMUMptspp N-acetylmuramate transport via PEP:Pyr PTS (periplasm) acmum_p + pep_c --> acmum6p_c + pyr_c "Transport, Inner Membrane" 0 1000 KPN_02764 and KPN_02763 and KPN_04044 and KPN_02762 Transport ACMUMptspp - rxn08048 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACMUMtex N-acetylmuramate transport via diffusion (extracellular to periplasm) acmum_e --> acmum_p "Transport, Outer Membrane" 0 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ACMUMtex - rxn08049 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACNAMt2pp N-acetylneuraminate proton symport (periplasm) acnam_p + h_p --> acnam_c + h_c "Transport, Inner Membrane" 0 1000 FHFOPAFH_00460 Transport ACNAMt2pp - rxn05487; rxn08050 3 has 89% homology to nanT from E coli iML1515 which catalyses this reaction
ACNAMtex N-acetylneuraminate transport via diffusion (extracellular to periplasm) acnam_e <=> acnam_p "Transport, Outer Membrane" -1000 1000 FHFOPAFH_01438 Transport ACNAMtex - rxn08051 1 "as strains able to utilise compound, need to transport it into cytoplasm, mechanism unknown"
ACNML N-Acetylneuraminate lyase acnam_c --> acmana_c + pyr_c Alternate Carbon Metabolism 0 1000 FHFOPAFH_00459 Catalytic ACNML R01201; R01207; R01408; R01410; R01811 rxn01322 3 has 88% homology to nanA from E coli iML1515 which catalyses this reaction
ACOAD1f Acyl-CoA dehydrogenase (butanoyl-CoA) btcoa_c + fad_c <=> b2coa_c + fadh2_c Membrane Lipid Metabolism -1000 1000 KPN_00235 Catalytic ACOAD1f R01175 rxn00872 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACOAD2 Acyl-CoA dehydrogenase (hexanoyl-CoA) h_c + hx2coa_c + nadh_c --> hxcoa_c + nad_c 0 1000 KPN_00235 Catalytic ACOAD2 - rxn10010 2 Evidence in Mycobacterium tuberculosis and Rhodococcus jostii with genomic evidence in Klebsiella.
ACOAD2f Acyl-CoA dehydrogenase (hexanoyl-CoA) fad_c + hxcoa_c <=> fadh2_c + hx2coa_c Membrane Lipid Metabolism -1000 1000 KPN_00235 Catalytic ACOAD2f R04751 rxn03251 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACOAD3 Acyl-CoA dehydrogenase (octanoyl-CoA) nad_c + occoa_c --> h_c + nadh_c + oc2coa_c 0 1000 KPN_00235 Catalytic ACOAD3 - rxn10011 2 Evidence in Mycobacterium tuberculosis and Rhodococcus jostii with genomic evidence in Klebsiella.
ACOAD3f Acyl-CoA dehydrogenase (octanoyl-CoA) fad_c + occoa_c <=> fadh2_c + oc2coa_c Membrane Lipid Metabolism -1000 1000 KPN_00235 Catalytic ACOAD3f R03777 rxn02679 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACOAD4 Acyl-CoA dehydrogenase (decanoyl-CoA) dcacoa_c + nad_c --> dc2coa_c + h_c + nadh_c 0 1000 KPN_00235 Catalytic ACOAD4 - rxn10012 2 Evidence in Mycobacterium tuberculosis and Rhodococcus jostii with genomic evidence in Klebsiella.
ACOAD4f Acyl-CoA dehydrogenase (decanoyl-CoA) dcacoa_c + fad_c <=> dc2coa_c + fadh2_c Membrane Lipid Metabolism -1000 1000 KPN_00235 Catalytic ACOAD4f R04754 rxn03253 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACOAD5 Acyl-CoA dehydrogenase (dodecanoyl-CoA) ddcacoa_c + nad_c --> dd2coa_c + h_c + nadh_c 0 1000 KPN_00235 Catalytic ACOAD5 - rxn10013 2 Evidence in Mycobacterium tuberculosis and Rhodococcus jostii with genomic evidence in Klebsiella.
ACOAD5f Acyl-CoA dehydrogenase (dodecanoyl-CoA) ddcacoa_c + fad_c <=> dd2coa_c + fadh2_c Membrane Lipid Metabolism -1000 1000 KPN_00235 Catalytic ACOAD5f R03857 rxn02720 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACOAD6 Acyl-CoA dehydrogenase (tetradecanoyl-CoA) nad_c + tdcoa_c --> h_c + nadh_c + td2coa_c 0 1000 KPN_00235 Catalytic ACOAD6 - rxn10014 2 Evidence in Mycobacterium tuberculosis and Rhodococcus jostii with genomic evidence in Klebsiella.
ACOAD6f Acyl-CoA dehydrogenase (tetradecanoyl-CoA) fad_c + tdcoa_c <=> fadh2_c + td2coa_c Membrane Lipid Metabolism -1000 1000 KPN_00235 Catalytic ACOAD6f R03990 rxn02803 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACOAD7 Acyl-CoA dehydrogenase (hexadecanoyl-CoA) nad_c + pmtcoa_c --> h_c + hdd2coa_c + nadh_c 0 1000 KPN_00235 Catalytic ACOAD7 - rxn05732 2 Evidence in Mycobacterium tuberculosis and Rhodococcus jostii with genomic evidence in Klebsiella.
ACOAD7f Acyl-CoA dehydrogenase (hexadecanoyl-CoA) fad_c + pmtcoa_c <=> fadh2_c + hdd2coa_c Membrane Lipid Metabolism -1000 1000 KPN_00235 Catalytic ACOAD7f R01279 rxn00946 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACOAD8f Acyl-CoA dehydrogenase (octadecanoyl-CoA) fad_c + stcoa_c <=> fadh2_c + od2coa_c Membrane Lipid Metabolism -1000 1000 KPN_00235 Catalytic ACOAD8f - rxn08053 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACOATA Acetyl-CoA ACP transacylase ACP_c + accoa_c <=> acACP_c + coa_c Membrane Lipid Metabolism -1000 1000 KPN_01092 and KPN_01089 Catalytic ACOATA R01624 rxn05349 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACODA Acetylornithine deacetylase acorn_c + h2o_c --> ac_c + orn_c 0 1000 KPN_04246 or KPN_01464 or 16852_1_42_04884 or 16870_7_82_04464 or Klebsiella_variicola_KSB2_3A_03189 or KPN_01735 Catalytic ACODA R00669 rxn29983 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACOLIPAabctex Arabinose modified core oligosaccharide lipid A transport via ABC system (periplasm to extracellular) acolipa_p + atp_c + h2o_c --> acolipa_e + adp_c + h_c + pi_c 0 1000 KPN_04667 and KPN_04666 and KPN_03609 and KPN_03611 and KPN_03610 and KPN_00051 and KPN_00673 Transport ACOLIPAabctex - - 2 Exchange reaction already present in iYL1228/V1. Evidence in E. coli. LPS modification genes generally conserved in gram-negative bacteria.
ACOLIPAt1ex arabinose modified core oligosaccharide lipid A transport via vector periplasm to extracellular LptA_p + acolipa_p --> acolipa_LptA_p 0 1000 (KPN_03611 and KPN_04666 and KPN_04667) or (KPN_03611 and KPN_04666 and KPN_04667 and KPN_03609) Transport ACOLIPAt1ex - - 4 Exchange reaction already present in iYL1228/V1. Evidence in E. coli. LPS modification genes generally conserved in gram-negative bacteria with Klebsiella protein structure available.
ACOLIPAt2ex arabinose modified core oligosaccharide lipid A transport via vector periplasm to extracellular acolipa_LptA_p --> LptA_p + acolipa_e 0 1000 KPN_00051 and KPN_00673 Transport ACOLIPAt2ex - - 4 Exchange reaction already present in iYL1228/V1. Evidence in E. coli. LPS modification genes generally conserved in gram-negative bacteria and Klebsiella structure available.
ACOLIPAtex Arabinose modified core oligosaccharide lipid A transport via vector (periplasm to extracellular) acolipa_p --> acolipa_e "Transport, Outer Membrane" 0 1000 - Transport ACOLIPAtex - rxn08056 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACONCtex Cisaconitat transport via diffusion extracellular to periplasm acon_C_e <=> acon_C_p -1000 1000 KPN_00282 or KPN_00956 or KPN_01445 or KPN_02636 Transport ACONCtex - rxn12788 2 Transport reaction for substrate that can be simulated by the model.
ACONCtupp Cisaconitate transport periplasm acon_C_p --> acon_C_c 0 1000 K_quasi_quasi_SB98_01440 and K_quasi_quasi_U41_01479 and K_quasi_quasi_U41_01478 Transport ACONCtupp - rxn12788 2 Transport reaction for substrate that can be simulated by the model.
ACONIs Aconitate isomerase (spontaneous) acon_T_c <=> acon_C_c Exchange -1000 1000 KPN_SPONT Catalytic ACONIs R02244 rxn01606 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACONMT Trans-aconitate methyltransferase acon_T_c + amet_c --> aconm_c + ahcys_c Unassigned 0 1000 KPN_01646 Catalytic ACONMT R05763 rxn04016 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACONTa Aconitase (half-reaction A_ Citrate hydro-lyase) cit_c <=> acon_C_c + h2o_c -1000 1000 KPN_00124 or KPN_01272 or 16870_8_36_04862 Catalytic ACONTa R01325 rxn00974 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACONTb Aconitase (half-reaction B_ Isocitrate hydro-lyase) acon_C_c + h2o_c <=> icit_c -1000 1000 KPN_00124 or KPN_01272 or 16870_8_36_04862 Catalytic ACONTb R01900 rxn01388 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACOTA Acetylornithine transaminase acorn_c + akg_c <=> acg5sa_c + glu__L_c -1000 1000 KPN_03745 or KPN_01493 or KPN_01221 or Klebsiella_pneumoniae_KSB1_7G_05067 or 16852_1_8_04571 Catalytic ACOTA R02283 rxn01637 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACP1_FMN Acid phosphatase (FMN) fmn_c + h2o_c --> pi_c + ribflv_c 0 1000 KPN_04311 or KPN_00408 or KPN_00875 Catalytic ACP1_FMN R00548 rxn00391 2 Evidence in E. coli.
ACPPAT120 Acyl-(acyl carrier protein):phosphate acyltransferase (C12:0) ddcaACP_c + h_c + pi_c --> ACP_c + ddcap_c 0 1000 KPN_01092 and KPN_01088 Catalytic ACPPAT120 - - 2 Involved in phospholipid biosynthesis. Gene evidence in Klebsiella (plsX & acpA).
ACPPAT140 Acyl-(acyl carrier protein):phosphate acyltransferase (C14:0) h_c + myrsACP_c + pi_c --> ACP_c + ttdcap_c 0 1000 KPN_01092 and KPN_01088 Catalytic ACPPAT140 - - 2 Involved in phospholipid biosynthesis. Gene evidence in Klebsiella (plsX & acpA).
ACPPAT141 Acyl-(acyl carrier protein):phosphate acyltransferase (C14:1) h_c + pi_c + tdeACP_c --> ACP_c + ttdceap_c 0 1000 KPN_01092 and KPN_01088 Catalytic ACPPAT141 - - 2 Involved in phospholipid biosynthesis. Gene evidence in Klebsiella (plsX & acpA).
ACPPAT160 Acyl-(acyl carrier protein):phosphate acyltransferase (C16:0) h_c + palmACP_c + pi_c --> ACP_c + hdcap_c 0 1000 KPN_01092 and KPN_01088 Catalytic ACPPAT160 - - 2 Involved in phospholipid biosynthesis. Gene evidence in Klebsiella (plsX & acpA).
ACPPAT161 Acyl-(acyl carrier protein):phosphate acyltransferase (C16:1) h_c + hdeACP_c + pi_c --> ACP_c + hdceap_c 0 1000 KPN_01092 and KPN_01088 Catalytic ACPPAT161 - - 2 Involved in phospholipid biosynthesis. Gene evidence in Klebsiella (plsX & acpA).
ACPPAT180 Acyl-(acyl carrier protein):phosphate acyltransferase (C18:0) h_c + ocdcaACP_c + pi_c --> ACP_c + ocdcap_c 0 1000 KPN_01092 and KPN_01088 Catalytic ACPPAT180 - - 2 Involved in phospholipid biosynthesis. Gene evidence in Klebsiella (plsX & acpA).
ACPPAT181 Acyl-(acyl carrier protein):phosphate acyltransferase (C18:1) h_c + octeACP_c + pi_c --> ACP_c + ocdceap_c 0 1000 KPN_01092 and KPN_01088 Catalytic ACPPAT181 - - 2 Involved in phospholipid biosynthesis. Gene evidence in Klebsiella (plsX & acpA).
ACPPD Acyl-carrier protein phosphodiesterase (4'-pantetheine-phosphohydrolase producing) ACP_c + h2o_c --> pan4p_c + apoACP_c + h_c 0 1000 KPN_00355 Catalytic - R01623 rxn06022 2 Evidence in E. coli.
ACPS1 Acyl-carrier protein synthase apoACP_c + coa_c --> ACP_c + h_c + pap_c 0 1000 KPN_02888 or 16703_5_22_03883 or K_pneumoniae_SB617_05103 or Klebsiella_pneumoniae_INF341_01706 or Klebsiella_pneumoniae_INF151_02758 Catalytic ACPS1 R01625 rxn29984 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACS Acetyl-CoA synthetase ac_c + atp_c + coa_c --> accoa_c + amp_c + ppi_c Pyruvate Metabolism 0 1000 KPN_04478 Catalytic ACS R00235 rxn00175 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACS2 Acetyl-CoA synthase (propionate) atp_c + ppa_c + coa_c --> amp_c + ppi_c + ppcoa_c 0 1000 KPN_04478 Catalytic ACS2 R00925 rxn00674 2 Evidence that propanoate is produced by Klebsiella.
ACSERL "O3-Acetyl-L-serine acetate-lyase (adding hydrogen sulfide), cytosol" acser_c + seln_c --> ac_c + h_c + selcys_c 0 1000 KPN_02761 Catalytic - R03601 rxn02571 2 Evidence in E. coli.
ACSERtex O-Acetyl-L-serine transport via diffusion (extracellular to periplasm) acser_e <=> acser_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ACSERtex - rxn08059; rxn08060 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACSERtpp O-Acetyl-L-serine export via facilitated transport acser_c --> acser_p "Transport, Inner Membrane" 0 1000 KPN_01622 or KPN_00233 Transport ACSERtpp - rxn08059; rxn08060 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACt2rpp Acetate reversible transport via proton symport (periplasm) ac_p + h_p <=> ac_c + h_c -1000 1000 KPN_00011 Transport ACt2rpp - rxn05488 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information. No gene-protein-rule previously associated with this reaction.
ACt4pp Na+/Acetate symport (periplasm) ac_p + na1_p --> ac_c + na1_c "Transport, Inner Membrane" 0 1000 KPN_04476 Transport ACt4pp - rxn08062 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACTD Acetoin dehydrogenase nad_c + actn__R_c --> h_c + nadh_c + diact_c 0 1000 KPN_02061 or K_quasivariicola_08A119_03708 or Klebsiella_variicola_INF336_05834 or Klebsiella_variicola_KSB2_3A_03791 Catalytic ACTD R02855 - 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACTDa Acetoin dehydrogenase actn__R_c + nadp_c --> diact_c + h_c + nadph_c Butanoate Metabolism 0 1000 KPN_02061 Catalytic ACTDa R02856 - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACtex Acetate transport via diffusion (extracellular to periplasm) ac_e <=> ac_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ACtex - rxn08063; rxn09787; rxn09866; rxn10904 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ACYCDTtex Alpha-Cyclodextrin Transport acdextrin_e <=> acdextrin_p -1000 1000 - Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
ACYCDTtpp Alpha-Cyclodextrin Transport (periplasm) acdextrin_p <=> acdextrin_c -1000 1000 - Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
ACYLAH Acylamide aminohydrolase bzmd_c + h2o_c --> bz_c + nh4_c 0 1000 Klebsiella_pneumoniae_INF201_05003 or K_variicola_variicola_At-22_03211 or K_quasi_simil_SB610_05358 or 16852_1_32_05312 or KPN_01770 or Klebsiella_variicola_KSB1_9F_02671 or Klebsiella_pneumoniae_INF341_01716 Catalytic - R05590 rxn03869 2 Reaction involved with known Klebsiella growth source.
ACYP_2 Acylphosphatase (2) actp_c + h2o_c --> ac_c + h_c + pi_c 0 1000 KPN_01004 Catalytic - R00317 rxn00227 2 Indirect evidence that Klebsiella produces this protein.
ADA Adenosine deaminase adn_c + h_c + h2o_c --> ins_c + nh4_c 0 1000 KPN_01958 or 16703_7_80_04952 Catalytic ADA R01560 rxn01137 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADCL 4-aminobenzoate synthase 4adcho_c --> 4abz_c + h_c + pyr_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_01094 Catalytic ADCL R05553 rxn03841 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADCOBNSYN Adenosylcobyric acid synthase adcob1nda_c + 4.0 atp_c + 4.0 gln__L_c + 4.0 h2o_c --> adcobn_c + 4.0 adp_c + 4.0 glu__L_c + 4.0 h_c + 4.0 pi_c 0 1000 16703_5_22_02254 Catalytic ADCOBNSYN - - 2 Part of cobalamin production which occurs in Klebsiella but direct evidence from Salmonella.
ADCPS1 Adenosylcobinamide-phosphate synthase adcobhex_c + appl_c + atp_c --> adocbi_c + adp_c + h_c + pi_c 0 1000 KPN_03199 or 16703_5_22_02269 Catalytic ADCPS1 R07302 rxn19001; rxn05054 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADCPS2 Adenosylcobinamide-phosphate synthase atp_c + adcobhex_c + applp_c --> adocbip_c + adp_c + 2.0 h_c + pi_c 0 1000 16703_5_22_02269 Catalytic ADCPS2 R06529 rxn04384 2 Part of cobalamin production which occurs in Klebsiella but direct evidence from Salmonella.
ADCS 4-amino-4-deoxychorismate synthase chor_c + gln__L_c --> 4adcho_c + glu__L_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_02328 and KPN_03746 Catalytic ADCS R01716 rxn01257 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADCYRS Adenosylcobyric acid synthase (glutamine-hydrolysing) adcobdam_c + 4.0 atp_c + 4.0 gln__L_c + 4.0 h2o_c --> adcobhex_c + 4.0 adp_c + 4.0 glu__L_c + 4.0 h_c + 4.0 pi_c 0 1000 KPN_03184 or 16703_5_22_02254 Catalytic ADCYRS R05225 rxn03540 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADD Adenine deaminase ade_c + h2o_c + h_c --> hxan_c + nh4_c Purine Metabolism 0 1000 KPN_02554 Catalytic ADD R01244 rxn00926 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADEt2rpp Adenine transport via proton symport (reversible) (periplasm) ade_p + h_p <=> ade_c + h_c "Transport, Inner Membrane" -1000 1000 KPN_04013 Transport ADEt2rpp - rxn05491; rxn08064 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADEtex Adenine transport via diffusion (extracellular to periplasm) ade_e <=> ade_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ADEtex - rxn08065; rxn09786; rxn10918 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADK1 Adenylate kinase amp_c + atp_c <=> 2.0 adp_c Nucleotide Salvage Pathway -1000 1000 KPN_00456 Catalytic ADK1 R00127 rxn00097 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADK3 Adentylate kinase (GTP) amp_c + gtp_c <=> adp_c + gdp_c Nucleotide Salvage Pathway -1000 1000 KPN_00456 Catalytic ADK3 - rxn08066 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADK4 Adentylate kinase (ITP) amp_c + itp_c <=> adp_c + idp_c Nucleotide Salvage Pathway -1000 1000 KPN_00456 Catalytic ADK4 - rxn08067 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADMDC Adenosylmethionine decarboxylase amet_c + h_c --> ametam_c + co2_c 0 1000 KPN_00126 or Klebsiella_pneumoniae_INF237_05260 Catalytic ADMDC R00178 rxn00127 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADNCYC Adenylate cyclase atp_c --> camp_c + ppi_c Nucleotide Salvage Pathway 0 1000 KPN_04305 Catalytic ADNCYC R00089 rxn00065 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADNK1 Adenosine kinase adn_c + atp_c --> adp_c + amp_c + h_c Nucleotide Salvage Pathway 0 1000 KPN_00456 Catalytic ADNK1 R00185 rxn00134 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADNt2pp Adenosine transport in via proton symport (periplasm) adn_p + h_p --> adn_c + h_c "Transport, Inner Membrane" 0 1000 KPN_03396 or KPN_02744 Catalytic ADNt2pp - rxn05318; rxn08068 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADNtex Adenosine transport via diffusion (extracellular to periplasm) adn_e <=> adn_p "Transport, Outer Membrane" -1000 1000 KPN_00363 Transport ADNtex - rxn08069; rxn11000 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADNUC Adenosine hydrolase adn_c + h2o_c --> ade_c + rib__D_c 0 1000 KPN_00025 or 16703_7_80_04950 or KPN_01912 or 16703_7_80_04976 Catalytic ADNUC R01245 rxn00927 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADOCBIK Adenosyl cobinamide kinase adocbi_c + atp_c --> adocbip_c + adp_c + h_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_03183 Catalytic ADOCBIK R05221 rxn03536 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADOCBIPS Adenosyl cobinamide phosphate synthase adcobn_c + applp_c + atp_c --> adocbip_c + adp_c + h_c + pi_c 0 1000 16703_5_22_02269 Catalytic ADOCBIPS - - 2 Part of cobalamin production which occurs in Klebsiella but direct evidence from Salmonella.
ADOCBLabcpp Adenosylcobalamin transport via ABC system (periplasm) adocbl_p + atp_c + h2o_c --> adocbl_c + adp_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_00173 and KPN_02169 and KPN_02166 Transport ADOCBLabcpp - rxn08070 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADOCBLPP Adenosylcobalamin phosphate phosphatase adocblp_c + h2o_p --> adocbl_c + pi_p 0 1000 KPN_00670 Catalytic - R11173 - 2 Part of cobalamin production which occurs in Klebsiella but direct evidence from Salmonella. Same as ADOCBLPP in STM_v1_0 with KPN_00670 having 64% seq ID.
ADOCBLPS Adenosylcobalamin phosphate synthase 5prdmbz_c + agdpcbi_c --> adocblp_c + gmp_c + h_c 0 1000 KPN_02464 Catalytic ADOCBLPS - - 2 Part of cobalamin production which occurs in Klebsiella but direct evidence from Salmonella.
ADOCBLS Adenosylcobalamin 5'-phosphate synthase agdpcbi_c + rdmbzi_c --> adocbl_c + gmp_c + h_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_02464 Catalytic ADOCBLS R05223 rxn03538 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADOCBLtonex Adenosylcobalimin transport via ton system (extermal) adocbl_e + h_p --> adocbl_p + h_c "Transport, Outer Membrane" 0 1000 KPN_04255 and KPN_03426 and KPN_02186 and KPN_03425 Transport ADOCBLtonex - rxn08071 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADPRDP ADPribose diphosphatase adprib_c + h2o_c --> amp_c + 2.0 h_c + r5p_c 0 1000 KPN_03768 or KPN_03448 Catalytic ADPRDP R01054 rxn00775 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADPT Adenine phosphoribosyltransferase ade_c + prpp_c --> amp_c + ppi_c 0 1000 KPN_00451 or KPN_00133 Catalytic ADPT R00190 rxn00139 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADPT2_1 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide:pyrophosphate phosphoribosyltransferase aicar_c + ppi_c <=> prpp_c + 5a4icam_c -1000 1000 KPN_00451 Catalytic - R04378 rxn03039 2 Evidence in E. coli.
ADSELK Adenylyl-selenate kinase atp_c + adsel_c --> adp_c + h_c + 3padsel_c 0 1000 KPN_03112 Catalytic - R04928 rxn03372 2 Evidence in E. coli.
ADSK Adenylyl-sulfate kinase aps_c + atp_c --> adp_c + h_c + paps_c Cysteine Metabolism 0 1000 KPN_03112 Catalytic ADSK R00509 rxn00361 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADSL1r Adenylsuccinate lyase dcamp_c <=> amp_c + fum_c -1000 1000 KPN_01139 or K_variicola_variicola_F2R9T_01771 Catalytic ADSL1r R01083 rxn00800 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADSL2r Adenylosuccinate lyase 25aics_c <=> aicar_c + fum_c -1000 1000 KPN_01139 or K_variicola_variicola_F2R9T_01771 Catalytic ADSL2r R04559 rxn03136 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ADSS Adenylosuccinate synthase asp__L_c + gtp_c + imp_c --> dcamp_c + gdp_c + 2.0 h_c + pi_c Purine and Pyrimidine Biosynthesis 0 1000 KPN_04576 Catalytic ADSS R01135 rxn00838 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AEPabcpp AEP transport via ABC system periplasm 2ameph_p + atp_c + h2o_c --> 2ameph_c + adp_c + h_c + pi_c 0 1000 KPN_04058 and KPN_04059 and KPN_04061 and KPN_04060 Transport AEPabcpp - - 2 Transport reaction for known Klebsiella growth substrate.
AEPPYRTA 2 aminoethylphosphonate pyruvate transaminase 2ameph_c + pyr_c --> Pald_c + ala__L_c 0 1000 KPN_04063 Catalytic AEPPYRTA R04152 rxn02900 2 Catalytic reaction for known Klebsiella growth substrate.
AEPtex AEP transport via diffusion extracellular to periplasm 2ameph_e <=> 2ameph_p -1000 1000 KPN_00282 or KPN_00956 or KPN_01445 or KPN_02636 Transport AEPtex - - 2 Transport reaction for known Klebsiella growth substrate.
AGDC N-acetylglucosamine-6-phosphate deacetylase acgam6p_c + h2o_c --> ac_c + gam6p_c 0 1000 KPN_00698 or Klebsiella_pneumoniae_INF151_05613 Catalytic AGDC R02059 rxn01484 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGM3PA N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide amidase anhgm3p_c + h2o_c --> LalaDgluMdap_c + anhgm_c Murein Recycling 0 1000 KPN_00112 Catalytic AGM3PA - rxn08073 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGM3PApp N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide amidase (periplasm) anhgm3p_p + h2o_p --> LalaDgluMdap_p + anhgm_p Murein Recycling 0 1000 KPN_03225 or KPN_04567 or KPN_02778 Catalytic AGM3PApp - rxn08073 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGM3PH "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide beta -1,4-N-acetylglucosaminidase" anhgm3p_c + h2o_c --> acgam_c + anhm3p_c Murein Recycling 0 1000 KPN_01104 Catalytic AGM3PH - rxn08074 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGM3Pt2pp GlcNAc-anhMurNAc tripeptide transport in via proton symport (periplasm) anhgm3p_p + h_p --> anhgm3p_c + h_c Murein Recycling 0 1000 KPN_00395 Catalytic AGM3Pt2pp - rxn08075 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGM4PA N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide amidase anhgm4p_c + h2o_c --> LalaDgluMdapDala_c + anhgm_c Murein Recycling 0 1000 KPN_00112 Catalytic AGM4PA - rxn08076 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGM4PApp N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide amidase (periplasm) anhgm4p_p + h2o_p --> LalaDgluMdapDala_p + anhgm_p Murein Recycling 0 1000 KPN_02778 or KPN_03225 or KPN_04567 Catalytic AGM4PApp - rxn08076 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGM4PCP "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase" anhgm4p_c + h2o_c --> ala__D_c + anhgm3p_c Murein Recycling 0 1000 KPN_02306 Catalytic AGM4PCP - rxn08077 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGM4PCPpp N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide L_D-carboxypeptidase (periplasmic) anhgm4p_p + h2o_p --> ala__D_p + anhgm3p_p 0 1000 KPN_02608 Catalytic AGM4PCPpp - rxn08077 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information. No gene-protein-rule previously associated with this reaction.
AGM4PH "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide beta -1,4-N-acetylglucosaminidase" anhgm4p_c + h2o_c --> acgam_c + anhm4p_c Murein Recycling 0 1000 KPN_01104 Catalytic AGM4PH - rxn08078 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGM4Pt2pp GlcNAc-anhMurNAc tetrapeptide transport in via proton symport (periplasm) anhgm4p_p + h_p --> anhgm4p_c + h_c Murein Recycling 0 1000 KPN_00395 Catalytic AGM4Pt2pp - rxn08079 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGMH "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl beta -1,4-N-acetylglucosaminidase" anhgm_c + h2o_c --> acgam_c + anhm_c Murein Recycling 0 1000 KPN_01104 Catalytic AGMH - rxn08080 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGMHE ADP-D-glycero-D-manno-heptose epimerase adphep_DD_c --> adphep_LD_c Lipopolysaccharide Biosynthesis / Recycling 0 1000 KPN_03963 Catalytic AGMHE R05176 rxn03511 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGMPTRCtpp Agmatine/putrescine antiporter (periplasm) agm_p + ptrc_c <=> agm_c + ptrc_p Exchange -1000 1000 KPN_00537 Transport AGMPTRCtpp - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGMT Agmatinase agm_c + h2o_c --> ptrc_c + urea_c 0 1000 KPN_03373 or Klebsiella_pneumoniae_INF078_05004 or KPN_02973 or 16870_8_9_05128 Catalytic AGMT R01157 rxn00858 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGMt2pp GlcNAc-anhMurNAc transport in via proton symport (periplasm) anhgm_p + h_p --> anhgm_c + h_c Murein Recycling 0 1000 KPN_00395 Transport AGMt2pp - rxn08081 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGMtex Agmatine transport via diffusion (extracellular to periplasm) agm_e <=> agm_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport AGMtex - rxn08082 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGPAT120 1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C12:0) 1ddecg3p_c + ddcaACP_c --> ACP_c + pa120_c Glycerophospholipid Metabolism 0 1000 KPN_03436 Catalytic AGPAT120 - rxn08083 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGPAT140 1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:0) 1tdecg3p_c + myrsACP_c --> ACP_c + pa140_c Glycerophospholipid Metabolism 0 1000 KPN_03436 Catalytic AGPAT140 - rxn08084 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGPAT141 1-tetradec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:1) 1tdec7eg3p_c + tdeACP_c --> ACP_c + pa141_c Glycerophospholipid Metabolism 0 1000 KPN_03436 Catalytic AGPAT141 - rxn08085 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGPAT160 1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0) 1hdecg3p_c + palmACP_c --> ACP_c + pa160_c Glycerophospholipid Metabolism 0 1000 KPN_03436 Catalytic AGPAT160 - rxn08086 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGPAT161 1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1) 1hdec9eg3p_c + hdeACP_c --> ACP_c + pa161_c Glycerophospholipid Metabolism 0 1000 KPN_03436 Catalytic AGPAT161 - rxn08087 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGPAT180 1-octadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:0) 1odecg3p_c + ocdcaACP_c --> ACP_c + pa180_c Glycerophospholipid Metabolism 0 1000 KPN_03436 Catalytic AGPAT180 - rxn08088 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGPAT181 1-octadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:1) 1odec11eg3p_c + octeACP_c --> ACP_c + pa181_c Glycerophospholipid Metabolism 0 1000 KPN_03436 Catalytic AGPAT181 - rxn08089 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGPR N-acetyl-g-glutamyl-phosphate reductase acg5sa_c + nadp_c + pi_c <=> acg5p_c + h_c + nadph_c Arginine and Proline Metabolism -1000 1000 KPN_04247 Catalytic AGPR R03443 rxn02465 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AGt3 Silver transport out via proton antiport ag_c + h_e --> ag_e + h_c Inorganic Ion Transport and Metabolism 0 1000 KPN_04738 and KPN_04736 and KPN_04737 and KPN_04739 Catalytic AGt3 - rxn08091 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AH6PI Arabino-3-hexulose-6-P Isomerase ah6p__D_c --> f6p_c 0 1000 KPN_02958 or Klebsiella_pneumoniae_INF231_05099 or 16870_7_51_01434 or 16703_7_73_02037 or Klebsiella_pneumoniae_INF008_00125 or Klebsiella_quasipneumoniae_INF291_04790 or 16870_7_82_04762 Catalytic AH6PI R05339 rxn03644 2 Evidence in Bacillus.
AHALc O-acetyl-L-homoserine acetate-lyase (cytoplasm) achms_c + trdrd_c + tsul_c --> ac_c + h_c + hcys__L_c + so3_c + trdox_c 0 1000 KPN_04233 Catalytic - R02026 rxn06078 2 Evidence in E. coli (protein structure).
AHCi Adenosylhomocysteinase ahcys_c + h2o_c <=> adn_c + hcys__L_c Methionine Metabolism -1000 1000 KPN_02462 Catalytic AHCi R00192 rxn00141 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AHCYSNS S-adenosylhomocysteine nucleosidase ahcys_c + h2o_c --> ade_c + rhcys_c 0 1000 KPN_00714 Catalytic AHCYSNS R00194 rxn00143 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information. Replaced KPN_00175 in original gene-protein-rule as it corresponded to a dGTPase (K01129) and not to the encoded protein (K01243).
AHGDx (S)-alpha-hydroxyglutarate dehydrogenase S2hglut_c + nad_c <=> akg_c + h_c + nadh_c -1000 1000 KPN_03348 Catalytic AHGDx R08198 rxn10432 2 Evidence in E. coli.
AHSERL4 Cysteine synthase Thiosulfate acser_c + trdrd_c + tsul_c --> ac_c + cys__L_c + h_c + so3_c + trdox_c 0 1000 KPN_02761 Catalytic AHSERL4 R04859 rxn05733 2 Evidence in E. coli.
AI2K Autoinducer-2 kinase atp_c + dhptd_c --> adp_c + dhptdp_c + h_c 0 1000 KPN_03509 Catalytic AI2K - - 3 Protein involved in Klebsiella biofilm formation (mutant gene KO).
AICART Phosphoribosylaminoimidazolecarboxamide formyltransferase 10fthf_c + aicar_c <=> fprica_c + thf_c Purine and Pyrimidine Biosynthesis -1000 1000 KPN_04388 Catalytic AICART R04560 rxn03137 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AIRC2 Phosphoribosylaminoimidazole carboxylase air_c + atp_c + hco3_c --> 5caiz_c + adp_c + h_c + pi_c Purine and Pyrimidine Biosynthesis 0 1000 KPN_00477 Catalytic AIRC2 R07404 rxn05114 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AIRC3 Phosphoribosylaminoimidazole carboxylase (mutase rxn) 5aizc_c <=> 5caiz_c Purine and Pyrimidine Biosynthesis -1000 1000 KPN_00478 Catalytic AIRC3 R07405 rxn05115 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AIRSK Aminoimidazole riboside kinase atp_c + airs_c --> adp_c + air_c + h_c 0 1000 KPN_00516 Catalytic AIRSK - - 2 Indirect evidence of presence in Klebsiella.
AIRStex Aminoimidazole riboside transport via diffusion extracellular to periplasm airs_e <=> airs_p -1000 1000 KPN_00282 or KPN_00956 or KPN_01445 or KPN_02636 Transport AIRStex - - 2 Transport reaction for substrate that can be simulated by the model.
AIRStpp Aminoimidazole riboside facilitated transport periplasm airs_p <=> airs_c -1000 1000 - Transport - - - 1 Transport reaction for substrate that can be simulated by the model.
AKGDDO Fe2+/Alpha-ketoglutarate-dependent dioxygenase lipa_c + akg_c + o2_c + 6.0 h_c --> 2hm_lipa_c + succ_c + co2_c 0 1000 KPN_02997 Catalytic - R12210 - 2 Evidence in Salmonella but no evidence in E. coli.
AKGDH 2-Oxogluterate dehydrogenase akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c 0 1000 KPN_00732 and (KPN_00120 or Klebsiella_pneumoniae_KSB2_1C_04030) and KPN_00733 Catalytic AKGDH R08549 rxn08094 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AKGt2rpp 2-oxoglutarate reversible transport via symport (periplasm) akg_p + h_p <=> akg_c + h_c "Transport, Inner Membrane" -1000 1000 KPN_02910 Transport AKGt2rpp - rxn05493; rxn08095; rxn09827 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AKGtex Alpha-ketoglutarate transport via diffusion (extracellular to periplasm) akg_e <=> akg_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport AKGtex - rxn08096; rxn10923; rxn13220 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AKP1 Alkaline phosphatase Dihydroneopterin ahdt_c + 3.0 h2o_c --> dhnpt_c + 2.0 h_c + 3.0 pi_c 0 1000 K_variicola_variicola_01A065_01666 or KPN_00327 Catalytic AKP1 R04620 rxn03167 2 Original evidence in Bacillus subtilius with protein structure available. Compared to protein structure has the same PhoD functional domain (PF09423.10) with 23% Seq ID. No direct evidence in Klebsiella but makes sense given that it is an accessory gene (N=4).
AKYHGL Alkylmercury lyase h_c + ch4hg2_c <=> hg2_c + ch4_c -1000 1000 Klebsiella_pneumoniae_INF278_05201 Catalytic - R09339 rxn19139 2 "Evidence of this protein being encoded on E. coli plasmids. Typically associated with water assoicated bacteria, which makes sense for Klebsiella (ubiquitous)."
ALAabcpp L-alanine transport via ABC system (periplasm) ala__L_p + atp_c + h2o_c --> adp_c + ala__L_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_03819 and KPN_03816 and KPN_03817 and KPN_03822 and KPN_03818 Transport ALAabcpp - rxn08097; rxn10170 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALAALAabcpp D-alanyl-D-alanine (DalaDala) transport via ABC system (periplasm) alaala_p + atp_c + h2o_c --> adp_c + alaala_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_03896 and KPN_03895 and KPN_03899 and KPN_03898 and KPN_03897 Transport ALAALAabcpp - rxn08098 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALAALAr D-alanine-D-alanine ligase (reversible) 2.0 ala__D_c + atp_c <=> adp_c + alaala_c + h_c + pi_c Cell Envelope Biosynthesis -1000 1000 KPN_00096 or KPN_00323 Catalytic ALAALAr R01150 rxn00851; rxn13802 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALAALAtex D-alanyl-D-alanine (DalaDala) transport via diffusion (extracellular to periplasm) alaala_e <=> alaala_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ALAALAtex - rxn08099 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALAGLUE L-alanyl-gamma-glutamate epimerase LalaDglu_c <=> LalaLglu_c -1000 1000 KPN_01308 or 16870_7_75_04903 Catalytic ALAGLUE R10938 rxn08100; rxn30454 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALAGLYabcpp Dipeptide transport via ABC system L alagly L_alagly_p + atp_c + h2o_c --> L_alagly_c + adp_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_03896 and KPN_03895 and KPN_03899 and KPN_03898 and KPN_03897 Transport ALAGLYabcpp - - 1 "transport into cytoplasm via dipeptide ABC transporter, similar to other dipeptide amino acids"
ALAGLYtex L-Alanyl-Glycine transport via diffusion (extracellular to periplasm) L_alagly_e <=> L_alagly_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ALAGLYtex - - 1 "transport of amino acids to periplasm via diffusion, present for other amino acid compounds in iYL1288"
ALAR Alanine racemase ala__L_c <=> ala__D_c -1000 1000 KPN_04440 or KPN_02308 or Klebsiella_pneumoniae_INF201_05059 Catalytic ALAR R00401 rxn00283 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALAt2pp L-alanine transport in via proton symport (periplasm) ala__L_p + h_p --> ala__L_c + h_c "Transport, Inner Membrane" 0 1000 KPN_04601 Transport ALAt2pp - rxn05496; rxn08101 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALAt4pp L-alanine transport in via sodium symport (periplasm) ala__L_p + na1_p --> ala__L_c + na1_c "Transport, Inner Membrane" 0 1000 KPN_00007 Transport ALAt4pp - rxn05215; rxn08102 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALATA_D2 D-alanine transaminase ala__D_c + pydx5p_c --> pyam5p_c + pyr_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_00903 and KPN_02876 Catalytic ALATA_D2 R01147 rxn00848 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALATA_L L-alanine transaminase akg_c + ala__L_c <=> glu__L_c + pyr_c -1000 1000 KPN_02680 or KPN_02735 Catalytic ALATA_L R00258 rxn00191 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information. No gene-protein-rule previously associated with this reaction.
ALATA_L2 Alanine transaminase ala__L_c + pydx5p_c --> pyam5p_c + pyr_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_00903 and KPN_02876 Catalytic ALATA_L2 - rxn08103 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALAtex L-alanine transport via diffusion (extracellular to periplasm) ala__L_e <=> ala__L_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ALAtex - rxn08104; rxn10921; rxn13221 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALAtpp L-alanine export via facilited diffusion ala__L_c --> ala__L_p 0 1000 KPN_02999 Transport ALAtpp - - 2 Export reaction for an amino acid known to be metabolised/produced by Klebsiella.
ALATRS Alanyl-tRNA synthetase ala__L_c + atp_c + trnaala_c --> alatrna_c + amp_c + ppi_c tRNA charging 0 1000 KPN_03029 Catalytic ALATRS - rxn11112 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALCD19 Alcohol dehydrogenase (glycerol) glyald_c + h_c + nadh_c <=> glyc_c + nad_c Alternate Carbon Metabolism -1000 1000 KPN_01952 Catalytic ALCD19 R01036 rxn00763 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALCD25xi Aldehyde dehydrogenase 2 phenylethanol NAD h_c + nadh_c + pacald_c --> nad_c + 2phetoh_c 0 1000 Klebsiella_variicola_KSB2_3A_05265 or KPN_01945 Catalytic ALCD25xi R02611 rxn01902 2 Evidence of being plasmid encoded in Pseudomonas.
ALCD2x Alcohol dehydrogenase (ethanol) etoh_c + nad_c <=> acald_c + h_c + nadh_c -1000 1000 KPN_02199 or KPN_01853 or KPN_01952 or KPN_02787 or KPN_03491 Catalytic ALCD2x R00754 rxn00543 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALCD2y "Alcohol dehydrogenase (ethanol, NADP)" etoh_c + nadp_c <=> acald_c + h_c + nadph_c -1000 1000 KPN_04683 or K_quasi_quasi_SB98_00080 or 16703_7_50_04199 or 16703_7_50_04193 or K_variicola_tropicalensis_CDC4241-71_04633 or AH0034T_C4PNMANXX_AGGCAGAA-AAGGAGTA_L006_05397 Catalytic ALCD2y R00746 rxn00536 2 Evidence in E. coli.
ALCD3ir Alcohol dehydrogenase Propanal h_c + nadh_c + ppal_c --> nad_c + ppoh_c 0 1000 KPN_03217 or Kqq_0001_BV or KPN_03491 or Klebsiella_variicola_INF345_04535 Catalytic ALCD3ir R02377 rxn01710 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALDD1 Aldehyde dehydrogenase formaldehyde NAD fald_c + h2o_c + nad_c --> for_c + 2.0 h_c + nadh_c 0 1000 18090_3_13_04840 Catalytic - R00604 rxn00429 2 Original evidence in Pseudomonas.
ALDD19xr "Aldehyde dehydrogenase (phenylacetaldehyde, NAD)" h2o_c + nad_c + pacald_c --> 2.0 h_c + nadh_c + pac_c 0 1000 KPN_01455 or 16852_1_74_04792 Catalytic ALDD19xr R02536 rxn01840 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALDD20x "Aldehyde dehydrogenase (indole-3-acetaldehyde, NAD)" h2o_c + nad_c + id3acald_c --> 2.0 h_c + nadh_c + ind3ac_c 0 1000 16852_1_74_04792 Catalytic ALDD20xm R02678 rxn01937 4 Klebsiella evidence for the catalytic protein.
ALDD22x 3-aminopropanal:NAD+ oxidoreductase h2o_c + nad_c + aproa_c --> ala_B_c + 2.0 h_c + nadh_c 0 1000 16852_1_74_04792 Catalytic ALDD22x R00904 rxn00653 4 Klebsiella evidence for the catalytic protein.
ALDD2x "Aldehyde dehydrogenase (acetaldehyde, NAD)" acald_c + h2o_c + nad_c --> ac_c + 2.0 h_c + nadh_c 0 1000 KPN_01018 or 16852_1_74_04792 Catalytic ALDD2x R00710 rxn00506 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALDD2y "Aldehyde dehydrogenase (acetaldehyde, NADP)" acald_c + h2o_c + nadp_c --> ac_c + 2.0 h_c + nadph_c Alternate Carbon Metabolism 0 1000 KPN_02991 Catalytic ALDD2y R00711 rxn00507 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALDD32 Aldehyde dehydrogenase D Glucuronolactone NADH 2.0 h2o_c + nad_c + glcurn_c <=> glcr_c + 3.0 h_c + nadh_c -1000 1000 16852_1_74_04792 Catalytic ALDD32 R02957 rxn02122 4 Klebsiella evidence for the catalytic protein.
ALDD3y "Aldehyde dehydrogenase (propanal, NADP)" h2o_c + nadp_c + ppal_c --> 2.0 h_c + nadph_c + ppa_c Alternate Carbon Metabolism 0 1000 KPN_02991 Catalytic ALDD3y - rxn08110 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALDH_1 (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase h2o_c + nad_c + mmtsa_c <=> 2.0 h_c + nadh_c + mmal_c -1000 1000 16852_1_74_04792 Catalytic - R03869 rxn02729 4 Klebsiella evidence for the catalytic protein.
ALKP Alkaline phosphatase dhap_c + h2o_c --> dha_c + pi_c 0 1000 KPN_03021 Catalytic ALKP R01010 rxn00743 4 Evidence that Klebsiella can ferment and produce dihydroxyacetone (substrate of this reaction). No evidence of this specific reaction.
ALLPI Allose 6-phosphate isomerase all6p_c <=> allul6p_c -1000 1000 KPN_01125 or 16703_7_86_05226 Catalytic ALLPI R09030 rxn08113 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALLTAMH Allantoate amidohydrolase alltt_c + 2.0 h2o_c + 2.0 h_c --> co2_c + 2.0 nh4_c + urdglyc_c Purine Metabolism 0 1000 KPN_01761 Catalytic ALLTAMH - rxn08114 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALLTAMH2 Allantoate amidinohydrolase alltt_c + h2o_c + 2.0 h_c --> co2_c + nh4_c + urdgci_c 0 1000 16703_5_22_01688 Catalytic ALLTAMH2 - - 2 Part of allantoin degradation pathway which is present in Klebsiella. Evidence of this specific catalytic protein in Klebsiella is unavailable.
ALLtex Allose transport via diffusion (extracellular to periplasm) all__D_e <=> all__D_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ALLtex - rxn08115 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALLTN Allantoinase alltn_c + h2o_c --> alltt_c + h_c 0 1000 KPN_01787 or 16703_5_22_01692 Catalytic ALLTN R02424 rxn01748 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALLTNRA Allantoin Racemase alltn__R_c <=> alltn_c -1000 1000 KPN_01788 Catalytic - R03925 rxn02761 2 Structure available for this protein in Klebsiella for this very reaction. 99% Seq ID between Kp structure and KPN_01788.
ALLTNt2rpp Allantoin transport in via proton symport (periplasm) alltn_p + h_p <=> alltn_c + h_c -1000 1000 16703_5_22_01694 Transport ALLTNt2rpp - rxn05682 2 Evidence that Klebsiella can grow on this substrate and therefore import it into the cell.
ALLTNtex Allantoin transport via diffusion (extracellular to periplasm) alltn_e <=> alltn_p -1000 1000 KPN_00282 or KPN_01445 or KPN_02636 Transport ALLTNtex - rxn08117 4 Transport reaction for known Klebsiella growth substrate.
ALLULPE Allulose 6-phosphate epimerase allul6p_c <=> f6p_c -1000 1000 KPN_01700 or KPN_01744 Catalytic ALLULPE R09031 rxn08118 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALPATE160pp "Apolipoprotein N-acyltransferase (phosphatidylethanolamine, periplasm)" alpp_p + pe160_p --> 2agpe160_p + lpp_p Unassigned 0 1000 KPN_02134 and KPN_00682 Catalytic ALPATE160pp - rxn08119 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALPATE160pp_1 Apolipoprotein N acyltransferase phosphatidylethanolamine periplasm apolpp_p + pe160_p --> 2agpe160_p + lpp_p 0 1000 KPN_00682 and KPN_02134 Catalytic ALPATE160pp_1 - - 2 Evidence in E. coli. Part of post-translational modification of bacterial lipoproteins.
ALPATG160pp "Apolipoprotein N-acyltransferase (phosphatidylglycerol, periplasm)" alpp_p + pg160_p --> 2agpg160_p + lpp_p Unassigned 0 1000 KPN_02134 and KPN_00682 Catalytic ALPATG160pp - rxn08120 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALPATG160pp_1 Apolipoprotein N acyltransferase phosphatidylglycerol periplasm apolpp_p + pg160_p --> 2agpg160_p + lpp_p 0 1000 KPN_00682 and KPN_02134 Catalytic ALPATG160pp_1 - - 2 Evidence in E. coli. Part of post-translational modification of bacterial lipoproteins.
ALPHNH Allophanate hydrolase allphn_c + h2o_c + 3.0 h_c --> 2.0 co2_c + 2.0 nh4_c 0 1000 K_quasi_simil_SB610_05348 or K_quasi_simil_SB610_05617 or 16703_5_14_01295 or K_quasi_simil_SB610_05375 Catalytic ALPHNH R00005 rxn00002 2 Evidence in Pseudomonas.
ALR2 Aldose reductase (methylglyoxal) h_c + mthgxl_c + nadph_c --> acetol_c + nadp_c Methylglyoxal Metabolism 0 1000 KPN_01195 or KPN_02741 or KPN_00221 or KPN_03432 Catalytic ALR2 R02528 rxn01832 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALR2x Aldose reductase (methylglyoxal) (nadh) h_c + mthgxl_c + nadh_c --> acetol_c + nad_c 0 1000 16703_5_14_01847 or CH0031R_C4PNMANXX_TAGGCATG-GTAAGGAG_L006_02548 Catalytic ALR2x R10718 rxn26144 2 Evidence in E. coli.
ALR3 Aldose reductase (acetol) acetol_c + h_c + nadph_c --> 12ppd__S_c + nadp_c 0 1000 Kqq_0001_BV Catalytic ALR3 - - 2 Evidence in Salmonella.
ALR4x Aldose reductase (acetol) h_c + lald__D_c + nadh_c --> 12ppd__R_c + nad_c 0 1000 KPN_04241 or KPN_03494 Catalytic ALR4x R10717 rxn08122 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ALTRH Altronate hydrolase altrn_c --> 2ddglcn_c + h2o_c Alternate Carbon Metabolism 0 1000 KPN_03519 Catalytic ALTRH R01540 rxn01122 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AM3PA Anhydrous-N-Acetylmuramyl-tripeptide amidase anhm3p_c + h2o_c --> LalaDgluMdap_c + anhm_c Murein Recycling 0 1000 KPN_00112 Catalytic AM3PA - rxn08123 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AM4PA Anhydrous-N-Acetylmuramyl-tetrapeptide amidase anhm4p_c + h2o_c --> LalaDgluMdapDala_c + anhm_c Murein Recycling 0 1000 KPN_00112 Catalytic AM4PA - rxn08124 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AM4PCP "Anhydrous-N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase" anhm4p_c + h2o_c --> ala__D_c + anhm3p_c Murein Recycling 0 1000 KPN_02306 Catalytic AM4PCP - rxn08125 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AMAA N-acetylmuramoyl-L-alanine amidase h2o_c + acmama_c --> ala__L_c + acmam_c 0 1000 KPN_00900 or Klebsiella_variicola_INF345_02119 or KPN_02778 or KPN_03225 or KPN_04567 Catalytic AMAA R04112 rxn02875 2 Evidence in Bacillus. K01447 contain an appropraite functional domain (PF01510.25) whereas K01448 contains PF01520.18 (using pfam-scan).
AMALT1 Amylomaltase (maltotriose) malt_c + malttr_c --> glc__D_c + maltttr_c Alternate Carbon Metabolism 0 1000 KPN_03786 Catalytic AMALT1 R01555; R06040; R07516 rxn08126 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AMALT2 Amylomaltase (maltotetraose) malt_c + maltttr_c --> glc__D_c + maltpt_c Alternate Carbon Metabolism 0 1000 KPN_03786 Catalytic AMALT2 R01555; R06040; R07516 rxn08127 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AMALT3 Amylomaltase (maltopentaose) malt_c + maltpt_c --> glc__D_c + malthx_c Alternate Carbon Metabolism 0 1000 KPN_03786 Catalytic AMALT3 R01555; R06040; R07516 rxn08128 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AMALT4 Amylomaltase (maltohexaose) malt_c + malthx_c --> glc__D_c + malthp_c Alternate Carbon Metabolism 0 1000 KPN_03786 Catalytic AMALT4 - rxn08129 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AMANAPEr N-acetylmannosamine 6-phosphate epimerase acmanap_c <=> acgam6p_c -1000 1000 KPN_03626 or K_quasi_simil_SB610_00468 Catalytic AMANAPEr R02087 rxn01506 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AMANK N-acetyl-D-mannosamine kinase acmana_c + atp_c --> acmanap_c + adp_c + h_c Alternate Carbon Metabolism 0 1000 FHFOPAFH_00462 Catalytic AMANK R02705 rxn01951 3 has 73% homology to nanK from E coli iML1515 which catalyses this reaction
AMAOTr Adenosylmethionine-8-amino-7-oxononanoate transaminase 8aonn_c + amet_c <=> amob_c + dann_c Cofactor and Prosthetic Group Biosynthesis -1000 1000 KPN_00799 Catalytic AMAOTr R03231 rxn02312 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AMID GUANIDINOBUTANAMIDE-NH3-RXN 4gudbd_c + h2o_c --> 4gudbutn_c + nh4_c 0 1000 KPN_00900 or 16852_1_32_05312 or K_variicola_variicola_At-22_03211 or Klebsiella_variicola_KSB1_9F_02671 or KPN_01770 or Klebsiella_pneumoniae_INF201_05003 or Klebsiella_pneumoniae_KSB1_6F_04856 or Klebsiella_pneumoniae_INF341_01716 or K_quasi_simil_SB610_05358 Catalytic AMID R03180 rxn02275 4 Evidence of this protein in Klebsiella and Pseudomonas.
AMID2 Amidase h2o_c + pad_c <=> nh4_c + pac_c -1000 1000 Klebsiella_pneumoniae_INF201_05003 or K_variicola_variicola_At-22_03211 or K_quasi_simil_SB610_05358 or 16852_1_32_05312 or Klebsiella_variicola_KSB1_9F_02671 or Klebsiella_pneumoniae_INF341_01716 Catalytic AMID2 R02540 rxn01843 4 Evidence of this protein in Klebsiella and Pseudomonas.
AMID3 Amidase h2o_c + iad_c --> ind3ac_c + nh4_c 0 1000 KPN_00900 or 16852_1_32_05312 or K_variicola_variicola_At-22_03211 or Klebsiella_variicola_KSB1_9F_02671 or KPN_01770 or Klebsiella_pneumoniae_INF201_05003 or Klebsiella_pneumoniae_KSB1_6F_04856 or Klebsiella_pneumoniae_INF341_01716 or K_quasi_simil_SB610_05358 Catalytic AMID3 R03096 rxn02222 4 Evidence of this protein in Klebsiella and Pseudomonas.
AMID5 R311-RXN aa_c + h2o_c + h_c --> acryl_c + nh4_c 0 1000 KPN_00900 or 16852_1_32_05312 or K_variicola_variicola_At-22_03211 or Klebsiella_variicola_KSB1_9F_02671 or KPN_01770 or Klebsiella_pneumoniae_INF201_05003 or Klebsiella_pneumoniae_KSB1_6F_04856 or Klebsiella_pneumoniae_INF341_01716 or K_quasi_simil_SB610_05358 Catalytic AMID5 R05551 rxn03839 4 Evidence of this protein in Klebsiella and Pseudomonas.
AMMQLT8 S-adenosylmethione:2-demthylmenaquinole methyltransferase (menaquinone 8) 2dmmql8_c + amet_c --> ahcys_c + h_c + mql8_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_04329 Catalytic AMMQLT8 - rxn08130 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AMMQT8_2 S-adenosylmethione:2-demethylmenaquinone methyltransferase 2dmmq8_c + amet_c --> ahcys_c + h_c + mqn8_c 0 1000 KPN_04329 Catalytic AMMQT8_2 - rxn10094 2 Evidence in E. coli but catalytic gene has been identified in Klebsiella via proteomics (LOCUS = UBIE_KLEP7).
AMPEP1 Aminopeptidase h2o_c + gly_asn__L_c <=> asn__L_c + gly_c -1000 1000 KPN_00181 Catalytic AMPEP1 - rxn12633 2 Evidence in E. coli which includes a protein structure (1C24). KPN_00181 has 95.82% sequence identity and 99% coverage to E. coli protein structure 1C24.
AMPEP10 Aminopeptidase h2o_c + gly_asp__L_c <=> asp__L_c + gly_c -1000 1000 KPN_00181 Catalytic AMPEP10 - rxn12634 2 Evidence in E. coli which includes a protein structure (1C24). KPN_00181 has 95.82% sequence identity and 99% coverage to E. coli protein structure 1C24.
AMPEP11 Aminopeptidase h2o_c + gly_pro__L_c <=> gly_c + h_c + pro__L_c -1000 1000 KPN_00181 Catalytic AMPEP11 - rxn12635 2 Evidence in E. coli which includes a protein structure (1C24). KPN_00181 has 95.82% sequence identity and 99% coverage to E. coli protein structure 1C24.
AMPEP12 Aminopeptidase h2o_c + ala_gln_c <=> ala__L_c + gln__L_c -1000 1000 KPN_00181 Catalytic AMPEP12 - rxn12636 2 Evidence in E. coli which includes a protein structure (1C24). KPN_00181 has 95.82% sequence identity and 99% coverage to E. coli protein structure 1C24.
AMPEP13 Aminopeptidase h2o_c + ala_L_asp__L_c <=> ala__L_c + asp__L_c -1000 1000 KPN_00181 or 16870_8_19_05199 or KPN_01674 Catalytic AMPEP13 - rxn12637 2 Evidence in E. coli which includes a protein structure (1C24). KPN_00181 has 95.82% sequence identity and 99% coverage to E. coli protein structure 1C24.
AMPEP14 Aminopeptidase h2o_c + met_L_ala__L_c <=> ala__L_c + met__L_c -1000 1000 KPN_00181 Catalytic AMPEP14 - rxn12638 2 Evidence in E. coli which includes a protein structure (1C24). KPN_00181 has 95.82% sequence identity and 99% coverage to E. coli protein structure 1C24.
AMPEP2 Aminopeptidase h2o_c + ala_L_thr__L_c <=> ala__L_c + thr__L_c -1000 1000 KPN_00181 Catalytic AMPEP2 - rxn12639 2 Evidence in E. coli which includes a protein structure (1C24). KPN_00181 has 95.82% sequence identity and 99% coverage to E. coli protein structure 1C24.
AMPEP3 Aminopeptidase h2o_c + gly_gln_c <=> gln__L_c + gly_c -1000 1000 KPN_00181 Catalytic AMPEP3 - rxn12640 2 Evidence in E. coli which includes a protein structure (1C24). KPN_00181 has 95.82% sequence identity and 99% coverage to E. coli protein structure 1C24.
AMPEP4 Aminopeptidase h2o_c + L_alagly_c <=> ala__L_c + gly_c -1000 1000 KPN_00181 Catalytic AMPEP4 - rxn12641 2 Evidence in E. coli which includes a protein structure (1C24). KPN_00181 has 95.82% sequence identity and 99% coverage to E. coli protein structure 1C24.
AMPEP5 Aminopeptidase h2o_c + ala_L_glu__L_c <=> ala__L_c + glu__L_c -1000 1000 KPN_00181 Catalytic AMPEP5 - rxn12642 2 Evidence in E. coli which includes a protein structure (1C24). KPN_00181 has 95.82% sequence identity and 99% coverage to E. coli protein structure 1C24.
AMPEP6 Aminopeptidase h2o_c + ala_leu_c <=> ala__L_c + leu__L_c -1000 1000 KPN_00181 Catalytic AMPEP6 - rxn12643 2 Evidence in E. coli which includes a protein structure (1C24). KPN_00181 has 95.82% sequence identity and 99% coverage to E. coli protein structure 1C24.
AMPEP7 Aminopeptidase h2o_c + ala_his_c <=> ala__L_c + his__L_c -1000 1000 KPN_00181 Catalytic AMPEP7 - rxn12644 2 Evidence in E. coli which includes a protein structure (1C24). KPN_00181 has 95.82% sequence identity and 99% coverage to E. coli protein structure 1C24.
AMPEP8 Aminopeptidase h2o_c + gly_glu__L_c <=> glu__L_c + gly_c -1000 1000 KPN_00181 Catalytic AMPEP8 - rxn12645 2 Evidence in E. coli which includes a protein structure (1C24). KPN_00181 has 95.82% sequence identity and 99% coverage to E. coli protein structure 1C24.
AMPEP9 Aminopeptidase h2o_c + gly_met_c <=> gly_c + met__L_c -1000 1000 KPN_00181 Catalytic AMPEP9 - rxn12646 3 Evidence in E. coli which includes a protein structure (1C24). KPN_00181 has 95.82% sequence identity and 99% coverage to E. coli protein structure 1C24.
AMPMS2 4-amino-2-methyl-5-phosphomethylpyrimidine synthetase air_c + h2o_c + nad_c --> 4ampm_c + 2.0 for_c + 3.0 h_c + nadh_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_04376 Catalytic AMPMS2 - rxn08131 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AMPMS3 4-amino-2-methyl-5-phosphomethylpyrimidine synthetase air_c + amet_c --> 4ampm_c + dad_5_c + for_c + 2.0 h_c + met__L_c + co_c 0 1000 KPN_04376 Catalytic - R03472 rxn02485 2 Evidence in thiamine biosynthesis in Klebsiella.
AMPN AMP nucleosidase amp_c + h2o_c --> ade_c + r5p_c 0 1000 KPN_02445 or KPN_03138 Catalytic AMPN R00182 rxn15018 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AMPTASEag Aminopeptidase (L-ala-gly) L_alagly_c + h2o_c --> ala__L_c + gly_c Unassigned 0 1000 KPN_00249 Catalytic - - - 2 "cleavage of this amino acid mediated by pepD (https://biocyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-3.4.13.18), pepD also utilised in reaction AMPTASEPG which was present in iYL1288"
AMPTASECG Alanyl aminopeptidase (cys-gly) cgly_c + h2o_c --> cys__L_c + gly_c Cysteine Metabolism 0 1000 KPN_04665 or KPN_02855 or KPN_00968 or KPN_02862 Catalytic AMPTASECG R00899 rxn00650 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AMPTASEgp Aminopeptidase (gly-pro) gly_pro__L_c + h2o_c --> gly_c + pro__L_c Arginine and Proline Metabolism 0 1000 KPN_01674 Catalytic - - - 3 cleavage of glycly-l-proline described in B. pertussis (doi: 10.1371/journal.pcbi.1005639). Gene homology to B. pertussis gene is 57%
AMPTASEPG Aminopeptidase (pro-gly) h2o_c + progly_c --> gly_c + pro__L_c Arginine and Proline Metabolism 0 1000 KPN_00968 or KPN_02855 or KPN_00249 or KPN_04665 Catalytic AMPTASEPG - rxn08133 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AMPtex AMP transport via diffusion (extracellular to periplasm) amp_e <=> amp_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport AMPtex - rxn08134; rxn13227 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ANHGMtex GlcNAc-anhMurNAc transport via diffusion (extracellular to periplasm) anhgm_e <=> anhgm_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ANHGMtex - rxn08135 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ANHMK 1_6-anhydrous-N-Acetylmuramate kinase anhm_c + atp_c + h2o_c --> acmum6p_c + adp_c + h_c 0 1000 KPN_01978 or Klebsiella_pneumoniae_INF237_05221 or 16870_7_82_04747 Catalytic ANHMK R12755 rxn08136 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ANPRT Anthranilate phosphoribosyltransferase anth_c + prpp_c --> ppi_c + pran_c "Tyrosine, Tryptophan, and Phenylalanine Metabolism" 0 1000 KPN_01256 Catalytic ANPRT R01073 rxn00791 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ANS Anthranilate synthase chor_c + gln__L_c --> anth_c + glu__L_c + h_c + pyr_c "Tyrosine, Tryptophan, and Phenylalanine Metabolism" 0 1000 KPN_01256 and KPN_01257 Catalytic ANS R00986 rxn00727 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ANS2 Anthranilate synthase 2 chor_c + nh4_c --> anth_c + h_c + h2o_c + pyr_c 0 1000 KPN_01257 and (KPN_03746 or KPN_01256) Catalytic ANS2 R00985 rxn00726 2 Evidence in Enterobacteriaceae.
ANt Acrylonitrile transport an_e <=> an_c -1000 1000 KPN_SPONT Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
AOBUTDs L-2-amino-3-oxobutanoate decarboxylation (spontaneous) 2aobut_c + h_c --> aact_c + co2_c Exchange 0 1000 KPN_SPONT Catalytic AOBUTDs R03758 rxn02666 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AOXPBDC 2-Amino-3-oxo-4-phosphonooxybutyrate decarboxylation (spontaneous) 2a3pp_c --> co2_c + 3a2oxpp_c + h_c 0 1000 KPN_00049 Catalytic - R07406 rxn05116 2 Evidence in E. coli.
AOXSr 8-amino-7-oxononanoate synthase ala__L_c + h_c + pmcoa_c <=> 8aonn_c + co2_c + coa_c -1000 1000 KPN_00801 or KPN_03962 Catalytic AOXSr R03210 rxn02297 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AOXSr2 8-amino-7-oxononanoate synthase ala__L_c + pimACP_c --> 8aonn_c + ACP_c + co2_c 0 1000 KPN_00801 or KPN_03962 Catalytic - R10124 rxn21864 4 Evidence in E. coli and part of biotin synthesis. One of the four protein components in gram-negative biotin ring assembly. Known Klebsiella growth substrate.
AP4AH Ap4A hydrolase ap4a_c + h2o_c --> 2.0 adp_c + 2.0 h_c Nucleotide Salvage Pathway 0 1000 KPN_00046 Catalytic AP4AH R00125 rxn00095 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AP4AS Ap4A synthetase 2.0 atp_c + h_c --> ap4a_c + ppi_c 0 1000 KPN_00502 Catalytic AP4AS - rxn26140 2 Damage metabolite in E. coli.
AP5AH Ap5A hydrolase ap5a_c + h2o_c --> adp_c + atp_c + 2.0 h_c Nucleotide Salvage Pathway 0 1000 KPN_00046 Catalytic AP5AH R09880 rxn08137 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
APAT2r 3-Aminopropanoate:2-oxoglutarate aminotransferase (c) akg_c + ala_B_c <=> glu__L_c + msa_c -1000 1000 KPN_03825 or 16852_1_74_04800 or KPN_00255 Catalytic - R00908 rxn00657 4 Evidence in E. coli but unpublished crystal structure available for Klebsiella. This has 99.8% seq ID with KPN_03825.
APCPT ATP:pantothenoyl-L-cysteine 4'-phosphotransferase atp_c + ptcys_c --> 4ppcys_c + adp_c 0 1000 KPN_04352 Catalytic - R04391 rxn03047 2 Evidence in E. coli.
APCS Aminopropylcadaverine synthase 15dap_c + ametam_c --> 5mta_c + h_c + na15dap_c 0 1000 KPN_00127 Catalytic APCS R08359 rxn12049 2 Bacterial crystal structure available (Thermotoga maritima).
APENTAMAH 5-aminopentanamide amidohydrolase (APENTAMAH) h2o_c + 5apentam_c + h_c --> 5aptn_c + nh4_c 0 1000 Klebsiella_pneumoniae_INF357_04919 Catalytic APENTAMAH R02273 rxn01630 2 Evidence from Psuedomonas putida.
APG3PAT120 Acyl-phosphate:glycerol-3-phosphate acyltransferase (C12:0) ddcap_c + glyc3p_c --> 1ddecg3p_c + h_c + pi_c 0 1000 KPN_03463 Catalytic APG3PAT120 R12241 - 2 Direct evidence in E. coli and genomic evidence in Klebsiella (plsY).
APG3PAT140 Acyl-phosphate:glycerol-3-phosphate acyltransferase (C14:0) glyc3p_c + ttdcap_c --> 1tdecg3p_c + h_c + pi_c 0 1000 KPN_03463 Catalytic APG3PAT140 R12241 - 2 Direct evidence in E. coli and genomic evidence in Klebsiella (plsY).
APG3PAT141 Acyl-phosphate:glycerol-3-phosphate acyltransferase (C14:1) glyc3p_c + ttdceap_c --> 1tdec7eg3p_c + h_c + pi_c 0 1000 KPN_03463 Catalytic APG3PAT141 R12241 - 2 Direct evidence in E. coli and genomic evidence in Klebsiella (plsY).
APG3PAT160 Acyl-phosphate:glycerol-3-phosphate acyltransferase (C16:0) glyc3p_c + hdcap_c --> 1hdecg3p_c + h_c + pi_c 0 1000 KPN_03463 Catalytic APG3PAT160 R12241 - 2 Direct evidence in E. coli and genomic evidence in Klebsiella (plsY).
APG3PAT161 Acyl-phosphate:glycerol-3-phosphate acyltransferase (C16:1) glyc3p_c + hdceap_c --> 1hdec9eg3p_c + h_c + pi_c 0 1000 KPN_03463 Catalytic APG3PAT161 R12241 - 2 Direct evidence in E. coli and genomic evidence in Klebsiella (plsY).
APG3PAT180 Acyl-phosphate:glycerol-3-phosphate acyltransferase (C18:0) glyc3p_c + ocdcap_c --> 1odecg3p_c + h_c + pi_c 0 1000 KPN_03463 Catalytic APG3PAT180 R12241 - 2 Direct evidence in E. coli and genomic evidence in Klebsiella (plsY).
APG3PAT181 Acyl-phosphate:glycerol-3-phosphate acyltransferase (C18:1) glyc3p_c + ocdceap_c --> 1odec11eg3p_c + h_c + pi_c 0 1000 KPN_03463 Catalytic APG3PAT181 R12241 - 2 Direct evidence in E. coli and genomic evidence in Klebsiella (plsY).
APH120 Acylphosphatase (C12:0) ddcap_c + h2o_c --> ddca_c + 2.0 h_c + pi_c 0 1000 KPN_01004 Catalytic - R01515 rxn01103 2 Evidence in E. coli.
APH140 Acylphosphatase (C14:0) h2o_c + ttdcap_c --> 2.0 h_c + pi_c + ttdca_c 0 1000 KPN_01004 Catalytic - R01515 rxn01103 2 Evidence in E. coli.
APH141 Acylphosphatase (C16:1) h2o_c + hdceap_c --> 2.0 h_c + hdcea_c + pi_c 0 1000 KPN_01004 Catalytic - R01515 rxn01103 2 Evidence in E. coli.
APH160 Acylphosphatase (C16:0) h2o_c + hdcap_c --> 2.0 h_c + hdca_c + pi_c 0 1000 KPN_01004 Catalytic - R01515 rxn01103 2 Evidence in E. coli.
APH161 Acylphosphatase (C16:1) h2o_c + hdceap_c --> 2.0 h_c + hdcea_c + pi_c 0 1000 KPN_01004 Catalytic - R01515 rxn01103 2 Evidence in E. coli.
APH180 Acylphosphatase (C18:0) h2o_c + ocdcap_c --> 2.0 h_c + ocdca_c + pi_c 0 1000 KPN_01004 Catalytic - R01515 rxn01103 2 Evidence in E. coli.
APH181 Acylphosphatase (C18:1) h2o_c + ocdceap_c --> 2.0 h_c + ocdcea_c + pi_c 0 1000 KPN_01004 Catalytic - R01515 rxn01103 2 Evidence in E. coli.
APNPT ATP:pantetheine 4'-phosphotransferase atp_c + ptth_c --> adp_c + pan4p_c 0 1000 KPN_04352 Catalytic APNPT R02971 rxn02128 4 KPN_04352 has 99% Seq identity with the Klebsiella protein structure.
APOLPPS Lpp signal peptidase - murein diglyceride_prolpp_c + h2o_c --> apolpp_p + lpp_sp_p 0 1000 KPN_00022 Catalytic APOLPPS - - 2 Direct evidence in E. coli and genomic evidence in Klebsiella (lspA).
APPLDHr Aminopropanol dehydrogenase reversible aact_c + h_c + nadh_c <=> appl_c + nad_c -1000 1000 KPN_04241 Catalytic APPLDHr R03759 rxn02667 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information. No gene-protein-rule previously associated with this reaction.
APRAUR 5-amino-6-(5-phosphoribosylamino)uracil reductase 5apru_c + h_c + nadph_c --> 5aprbu_c + nadp_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_00366 Catalytic APRAUR R03458 rxn02474 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
APRTO2_1 RXN-1 h2o2_c + h_p + n4abutn_c + nh4_c --> aprut_c + h2o_c + h_c + o2_c 0 1000 KPN_01467 Catalytic APRTO2_1 - - 2 Evidence of this protein (studied regulation) in K. aerogenes.
APTNAT 5-aminopentanoate:2-oxoglutarate aminotransferase akg_c + 5aptn_c <=> glu__L_c + oxptn_c -1000 1000 KPN_00255 or KPN_03825 Catalytic APTNAT R02274 rxn01631 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARABDI L-fucose isomerase arab__D_c <=> rbl__D_c -1000 1000 16870_7_66_00948 Catalytic ARABDI R01577 rxn01152 3 Gene KO mutant evidence of reaction and protein in Klebsiella.
ARAI L-arabinose isomerase arab__L_c <=> rbl__L_c Alternate Carbon Metabolism -1000 1000 KPN_00061 Catalytic ARAI R01761 rxn01292 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARAT Methionine transaminase 4met2obut_c + glu__L_c --> akg_c + h_c + met__L_c Methionine Metabolism 0 1000 KPN_01365 or KPN_04441 Catalytic ARAT R07396 rxn05108 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARBabcpp L-arabinose transport via ABC system (periplasm) arab__L_p + atp_c + h2o_c --> adp_c + arab__L_c + h_c + pi_c 0 1000 KPN_02394 and KPN_02396 and Klebsiella_pneumoniae_INF361_01693 Transport ARBabcpp - rxn05173 2 Transport reaction to complete the pathway from v1.
ARBt2rpp L-arabinose transport via proton symport (periplasm) arab__L_p + h_p <=> arab__L_c + h_c "Transport, Inner Membrane" -1000 1000 KPN_03264 or AFBMIAHL_04773 Transport ARBt2rpp - rxn05500 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARBt3ipp L-arabinose transport via proton antiport (periplasm) arab__L_c + h_p --> arab__L_p + h_c "Transport, Inner Membrane" 0 1000 KPN_01628 Transport ARBt3ipp - rxn08141 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARBtex L-arabinose transport via diffusion (extracellular to periplasm) arab__L_e <=> arab__L_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ARBtex - rxn08142 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARBTNabcpp Aerobactin transport via ABC system (periplasm) arbtn_fe3_p + atp_c + h2o_c --> adp_c + arbtn_fe3_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_00166 and KPN_00167 and KPN_00168 Transport ARBTNabcpp - rxn08143; rxn13800 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARBTNS Aerobactin synthase n2cit6hll_c + n6an6hll_c + atp_c + fe3_c --> arbtn_fe3_c + amp_c + ppi_c + 4.0 h_c 0 1000 Klebsiella_pneumoniae_INF079_05146 Catalytic - R10091 rxn40000 2 Plasmid encoded gene in E. coli (iron-regulated aerobactin operon).
ARBTptspp Arbutin transport via PEP:Pyr PTS (periplasm) arbt_p + pep_c --> arbt6p_c + pyr_c Transport 0 1000 KPN_02762 and KPN_02763 and KPN_03051 Transport ARBTptspp - rxn05501 2 "in E. coli iML1515 this compound is transported by a PTS transporter and is phosphorylated using pstI, pstH and ascF (90% homology) "
ARBTtex Arbutin transport arbt_e --> arbt_p "Transport, Outer Membrane" 0 1000 KPN_00282 or KPN_02636 or KPN_00956 or KPN_01445 Transport ARBTtex - rxn30248 2 "in E. coli iML1515 this compound enters the periplasm by diffusion, use same mechanism here"
ARD_1 Acireductone dioxygenase dhmtp_c + o2_c --> 4met2obut_c + for_c + h_c 0 1000 KPN_00643 Catalytic ARD_1 R07364 rxn05092 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information. No gene-protein-rule previously associated with this reaction.
ARD1 Acireductone dioxygenase dhmtp_c + o2_c --> co_c + for_c + h_c + mtpp_c Methionine Metabolism 0 1000 KPN_00643 Catalytic ARD1 R07363 rxn05091 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARGabcpp L-arginine transport via ABC system (periplasm) arg__L_p + atp_c + h2o_c --> adp_c + arg__L_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 (KPN_02700 and KPN_02698 and KPN_02697 and KPN_02696) or (KPN_00897 and KPN_00893 and KPN_00896 and KPN_00894 and KPN_00895) Transport ARGabcpp - rxn05154; rxn08151; rxn11236 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARGDCpp Arginine decarboxylase arg__L_p + h_p --> agm_p + co2_p Arginine and Proline Metabolism 0 1000 KPN_03374 Catalytic ARGDCpp R00566 rxn00405 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARGDr Arginine deiminase arg__L_c + h2o_c --> citr__L_c + nh4_c 0 1000 Klebsiella_pneumoniae_INF151_05602 Catalytic ARGDr R00552 rxn00395 2 Evidence in Psuedomonas aerugisnosa. Bacterial adaptation to acid environments.
ARGMO ARGININE-2-MONOOXYGENASE-RXN arg__L_c + o2_c --> 4gudbd_c + co2_c + h2o_c 0 1000 KPN_03374 Catalytic ARGMO - - 2 Bacterial evidence.
ARGORNt7pp Arginine/ornithine antiporter (periplasm) arg__L_p + orn_c <=> arg__L_c + orn_p "Transport, Inner Membrane" -1000 1000 KPN_01524 Transport ARGORNt7pp - rxn08153; rxn10131 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARGSL Argininosuccinate lyase argsuc_c <=> arg__L_c + fum_c Arginine and Proline Metabolism -1000 1000 KPN_03580 or KPN_04249 Catalytic ARGSL R01086 rxn00802 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARGSS Argininosuccinate synthase asp__L_c + atp_c + citr__L_c --> amp_c + argsuc_c + h_c + ppi_c Arginine and Proline Metabolism 0 1000 KPN_03580 or KPN_04249 Catalytic ARGSS R01954 rxn01434 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARGt3pp L-arginine transport out via proton antiport (cytoplasm to periplasm) arg__L_c + h_p --> arg__L_p + h_c "Transport, Inner Membrane" 0 1000 KPN_03352 Transport ARGt3pp - rxn08154; rxn13228 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARGtex L-arginine transport via diffusion (extracellular to periplasm) arg__L_e <=> arg__L_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ARGtex - rxn08155; rxn10840 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARGTRS Arginyl-tRNA synthetase arg__L_c + atp_c + trnaarg_c --> amp_c + argtrna_c + ppi_c tRNA charging 0 1000 KPN_02388 Catalytic ARGTRS R03646 rxn06432 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ARHGDx (R)-alpha-hydroxyglutarate dehydrogenase nad_c + r2hglut_c <=> akg_c + h_c + nadh_c -1000 1000 KPN_03348 Catalytic ARHGDx - - 2 Evidence in E. coli.
ARMEPNS Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase atp_c + mepn_c --> ade_c + rpntp_c 0 1000 KPN_04494 and KPN_04498 and KPN_04497 and KPN_04499 Catalytic ARMEPNS R10185 rxn26456 2 Evidence of the phn operon in K. aerogenes.
AROH L-Arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming) Largn_c + h_c --> co2_c + h2o_c + phe__L_c 0 1000 KPN_02920 Catalytic - R00691 rxn00490 2 Evidence in E. coli.
ARSO4SH Aryl-sulfate sulfohydrolase h2o_c + arso4_c --> 2.0 h_c + so4_c + phenol_c 0 1000 KPN_00527 Catalytic - - rxn48514 4 Protein structure exists for Klebsiella.
ASAD Aspartate-semialdehyde dehydrogenase aspsa_c + nadp_c + pi_c <=> 4pasp_c + h_c + nadph_c -1000 1000 KPN_03799 or KPN_01773 or KPN_02709 Catalytic ASAD R02291 rxn01643 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASCBPL L-ascorbate 6-phosphate lactonase ascb6p_c + h2o_c --> 3dhgulnp_c + h_c 0 1000 KPN_04585 or Klebsiella_pneumoniae_KSB1_6G_05580 Catalytic ASCBPL R07677 rxn07492 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASCBptspp L-ascorbate transport via PEP:Pyr PTS (periplasm) ascb__L_p + pep_c --> ascb6p_c + pyr_c "Transport, Inner Membrane" 0 1000 KPN_04588 and KPN_04586 and KPN_04587 and KPN_02763 and KPN_02762 Transport ASCBptspp - rxn08158; rxn13758 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASCBtex L-ascorbate transport via diffusion (extracellular to periplasm) ascb__L_e <=> ascb__L_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ASCBtex - rxn08159 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASNN L-asparaginase asn__L_c + h2o_c --> asp__L_c + nh4_c Alanine and Aspartate Metabolism 0 1000 KPN_01203 or KPN_00861 Catalytic ASNN R00485 rxn00342 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASNNpp L-asparaginase asn__L_p + h2o_p --> asp__L_p + nh4_p 0 1000 KPN_01165 or KPN_01203 or 16703_7_53_04698 or K_quasivariicola_08A119_03439 or Klebsiella_pneumoniae_INF334_04996 Catalytic ASNNpp R00485 rxn00342 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASNS1 Asparagine synthase (glutamine-hydrolysing) asp__L_c + atp_c + gln__L_c + h2o_c --> amp_c + asn__L_c + glu__L_c + h_c + ppi_c Alanine and Aspartate Metabolism 0 1000 KPN_00695 Catalytic ASNS1 R00578 rxn00416; rxn11214 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASNS2 Asparagine synthetase asp__L_c + atp_c + nh4_c --> amp_c + asn__L_c + h_c + ppi_c Alanine and Aspartate Metabolism 0 1000 KPN_04149 Catalytic ASNS2 R00483 rxn00340 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASNt2rpp L-asparagine reversible transport via proton symport (periplasm) asn__L_p + h_p <=> asn__L_c + h_c "Transport, Inner Membrane" -1000 1000 KPN_01906 Transport ASNt2rpp - rxn05508; rxn08161; rxn09782; rxn11321; rxn13230 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASNtex L-asparagine transport via diffusion (extracellular to periplasm) asn__L_e <=> asn__L_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ASNtex - rxn05220; rxn08162 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASNTRS Asparaginyl-tRNA synthetase asn__L_c + atp_c + trnaasn_c --> amp_c + asntrna_c + ppi_c tRNA charging 0 1000 KPN_00961 Catalytic ASNTRS R03648 rxn06434; rxn11114 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASNTRS_1 Asparaginyl tRNA synthetase asn__L_c + atp_c + trnaasn_c --> amp_c + asntrna_c + ppi_c 0 1000 KPN_00961 Catalytic ASNTRS_1 R03648 rxn06434 2 There is a microbial version of this reaction but whether it has a specific or generate tRNA synthetase is dependent on the species. Unknown for Klebsiella.
ASO3t8pp Arsenite efflux via ATP hydrolysis (periplasm) aso3_c + atp_c + h2o_c --> adp_c + aso3_p + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_03304 Transport ASO3t8pp - rxn08163 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASO3tex Arsenite transport via diffusion (extracellular to periplasm) aso3_e <=> aso3_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ASO3tex - rxn05507; rxn08164 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASP1DC Aspartate 1-decarboxylase asp__L_c + h_c --> ala_B_c + co2_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_00139 Catalytic ASP1DC R00489 rxn00346 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASPA2 3-sulfino-L-alanine 2-oxoglutarate aminotransferase 3sala_c + akg_c + h_c --> glu__L_c + 3snpyr_c 0 1000 16703_7_36_05038 or Klebsiella_variicola_KSB1_8J_01660 or Klebsiella_variicola_KSB2_3A_04143 or 16870_8_59_04080 or KPN_00955 Catalytic - R02619 rxn01906 2 Evidence in Bacillus and Campylobacter. Metabolites are already in the Kp model (V1)
ASPabcpp L-aspartate transport via ABC system (periplasm) asp__L_p + atp_c + h2o_c --> adp_c + asp__L_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_00678 and KPN_00680 and KPN_00679 and KPN_00681 Transport ASPabcpp - rxn05152; rxn08165 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASPCT Aspartate carbamoyltransferase asp__L_c + cbp_c --> cbasp_c + h_c + pi_c Purine and Pyrimidine Biosynthesis 0 1000 KPN_04657 and KPN_04656 Catalytic ASPCT R01397 rxn01018 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASPK Aspartate kinase asp__L_c + atp_c <=> 4pasp_c + adp_c Threonine and Lysine Metabolism -1000 1000 KPN_04412 or KPN_00002 or KPN_04234 Catalytic ASPK R00480 rxn00337 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASPO1 L-aspartate oxidase asp__L_c + h2o_c + o2_c --> h2o2_c + nh4_c + oaa_c 0 1000 KPN_02899 Catalytic - R00357 rxn00262 2 Evidence in E. coli (protein structure).
ASPO2y L-aspartate oxidase asp__L_c + nadp_c --> 2.0 h_c + iasp_c + nadph_c 0 1000 KPN_03362 Catalytic - R07407 rxn05117 2 Evidence in E. coli which suggests this reaction is FAD dependent. However there is evidence outside of E. coli that this could also used NAD/NADH.
ASPO3 L-aspartate oxidase asp__L_c + q8_c --> h_c + iasp_c + q8h2_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_02899 Catalytic ASPO3 - rxn08166 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASPO4 L-aspartate oxidase asp__L_c + mqn8_c --> h_c + iasp_c + mql8_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_02899 Catalytic ASPO4 - rxn08167 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASPO5 L-aspartate oxidase asp__L_c + fum_c --> h_c + iasp_c + succ_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_02899 Catalytic ASPO5 - rxn08168 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASPO6 L-aspartate oxidase asp__L_c + o2_c --> h2o2_c + h_c + iasp_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_02899 Catalytic ASPO6 R00481 rxn00338 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASPR Aspartate racemase asp__D_c <=> asp__L_c -1000 1000 KPN_03254 or 16870_8_36_00851 or Klebsiella_pneumoniae_INF078_05296 Catalytic ASPR R00491 rxn00348 2 Evidence in E. coli (protein structure).
ASPT L-aspartase asp__L_c --> fum_c + nh4_c Alanine and Aspartate Metabolism 0 1000 KPN_04529 Catalytic ASPT R00490 rxn00347 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASPt2_2pp Aspartate transport via proton symport (2 H) (periplasm) asp__L_p + 2.0 h_p --> asp__L_c + 2.0 h_c "Transport, Inner Membrane" 0 1000 KPN_03878 Transport ASPt2_2pp - rxn08169; rxn10151 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASPt2_3pp L-asparate transport via proton symport (3 H) (periplasm) asp__L_p + 3.0 h_p --> asp__L_c + 3.0 h_c "Transport, Inner Membrane" 0 1000 KPN_04528 or KPN_04367 Transport ASPt2_3pp - rxn10155 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASPt2pp L-aspartate transport in via proton symport (periplasm) asp__L_p + h_p --> asp__L_c + h_c "Transport, Inner Membrane" 0 1000 KPN_04480 Transport ASPt2pp - rxn05217; rxn09781; rxn09825; rxn13233 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASPTA Aspartate transaminase akg_c + asp__L_c <=> glu__L_c + oaa_c -1000 1000 KPN_00645 or KPN_00955 or 16703_7_36_05038 or Klebsiella_variicola_KSB1_8J_01660 or Klebsiella_variicola_KSB2_3A_04143 or 16870_8_59_04080 Catalytic ASPTA R00355 rxn00260 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASPtex L-aspartate transport via diffusion (extracellular to periplasm) asp__L_e <=> asp__L_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport ASPtex - rxn08170; rxn10906; rxn13232 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ASPtpp L-aspartate uptake via facillitated diffusion asp__L_p <=> asp__L_c -1000 1000 KPN_02239 Transport ASPtpp - - 2 Transport reaction to complete the pathway from v1.
ASPTRS Aspartyl-tRNA synthetase asp__L_c + atp_c + trnaasp_c --> amp_c + asptrna_c + ppi_c tRNA charging 0 1000 KPN_02380 Catalytic ASPTRS R05577 rxn06936 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AST succinyl-CoA:L-arginine N2-succinyltransferase arg__L_c + succoa_c --> coa_c + h_c + sucarg_c 0 1000 KPN_01222 or KPN_01494 or AH0360_C4PNMANXX_GTAGAGGA-AAGGAGTA_L006_04522 or 16852_1_8_04572 or Klebsiella_pneumoniae_KSB1_7G_05068 Catalytic AST R00832 rxn00601 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ATHRDHr L-allo-threonine dehydrogenase athr__L_c + nadp_c <=> 2aobut_c + h_c + nadph_c Threonine and Lysine Metabolism -1000 1000 KPN_01590 Catalytic ATHRDHr R10851 rxn08172 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ATPM ATP maintenance requirement atp_c + h2o_c --> adp_c + h_c + pi_c Biomass and maintenance functions 6.8 6.8 - Catalytic ATPM R00086 rxn00062; rxn09694; rxn11300 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ATPPRT ATP phosphoribosyltransferase atp_c + prpp_c --> ppi_c + prbatp_c Histidine Metabolism 0 1000 KPN_02475 Catalytic ATPPRT R01071 rxn00789 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
ATPS4rpp ATP synthase (four protons for one ATP) (periplasm) adp_c + 4.0 h_p + pi_c <=> atp_c + h2o_c + 3.0 h_c Oxidative Phosphorylation -1000 1000 (KPN_04141 and KPN_04137 and KPN_04144 and KPN_04139 and KPN_04143 and KPN_04138 and KPN_04142 and KPN_04140 and KPN_04136) or (KPN_04141 and KPN_04137 and KPN_04139 and KPN_04143 and KPN_04138 and KPN_04142 and KPN_04140 and KPN_04136) Catalytic ATPS4rpp - rxn08173; rxn10042 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
AU1abcpp Gold Au 1 ABC transporter periplasm atp_c + au_c + h2o_c --> adp_c + au_p + h_c + pi_c 0 1000 16703_5_13_05294 Transport AU1abcpp - - 2 Evidence in Salmonella. Part of heavy metal resistance to gold.
BACOAT Butanoyl-CoA Acetoacetate CoA-transferase btcoa_c + acac_c --> but_c + aacoa_c 0 1000 (K_africana_200023T_02421 and K_africana_200023T_02422) or (Klebsiella_pneumoniae_kppr1.contigset_00309 and Klebsiella_pneumoniae_KSB2_1C_01466) Catalytic - R01365 rxn00994 2 Evidence in E. coli.
BALAt2pp Beta-alanine transport in via proton symport (periplasm) ala_B_p + h_p --> ala_B_c + h_c "Transport, Inner Membrane" 0 1000 KPN_04601 Transport BALAt2pp - rxn05495; rxn08174 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BALAtex Beta-alanine transport via diffusion (extracellular to periplasm) ala_B_e <=> ala_B_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport BALAtex - rxn08175 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BDG2HCGHD Beta-D-Glucosyl-2-coumarinate glucohydrolase h2o_c + bdg2hc_c --> glc__D_c + h_c + 2coum_c 0 1000 16870_7_82_04749 or AUSMDU00003506_S45_L999_02771 or KPN_02568 or Klebsiella_pneumoniae_INF079_01123 Catalytic - R04998 rxn03402 4 Protein purification evidence in Klebsiella. Homotetramer = four identical subunits (OR statement).
BDH 3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN nad_c + bhb_c <=> acac_c + h_c + nadh_c -1000 1000 KPN_02057 Catalytic - R01361 rxn00992 2 No specific evidence in Kp but evidence in bacteria.
BETALDHx Betaine-aldehyde dehydrogenase betald_c + h2o_c + nad_c --> glyb_c + 2.0 h_c + nadh_c Unassigned 0 1000 KPN_00585 Catalytic BETALDHx R02565 rxn01867 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BETALDHy Betaine-aldehyde dehydrogenase betald_c + h2o_c + nadp_c --> glyb_c + 2.0 h_c + nadph_c Unassigned 0 1000 KPN_00585 Catalytic BETALDHy R02566 rxn01868 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BFCL Benzoylformate carboxy-lyase bzf_c <=> bzal_c + co2_c -1000 1000 16852_1_18_00212 or K_variicola_variicola_F2R9T_01295 Catalytic - R01764 rxn01294 2 Evidence in Pseudomonas.
BGLA1 6-phospho-beta-glucosidase 6pgg_c + h2o_c --> g6p_c + glc__D_c 0 1000 KPN_01234 or KPN_03052 or 16870_8_26_03859 or KPN_03330 Catalytic BGLA1 R00839 rxn00608 2 Evidence in E. coli and genomically identified in Klebsiella (bglA).
BGLK Beta-glucoside kinase atp_c + cellb_c + h2o_c --> adp_c + g6p_c + glc__D_c + h_c Starch and Sucrose Metabolism 0 1000 KPN_02823 Catalytic BGLK - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BHBtpp Transport of (r)-3-hydroxybutanoate [extraorganism-cytosol](passive) bhb_p + h_p --> bhb_c + h_c 0 1000 16703_5_1_00870 Transport BHBtpp - - 2 Transport reaction for known Klebsiella growth substrate.
BIOMASS_Core_Oct2019 BIOMASS_Core_Oct2019 0.007 adphep_LD_c + 0.621 ala__L_c + 0.306 arg__L_c + 0.204 asn__L_c + 0.31 asp__L_c + 71.785 atp_c + 0.0013 clpn160_p + 0.0004 clpn161_p + 0.0002 clpn181_p + 0.117 ctp_c + 0.078 cys__L_c + 0.017 datp_c + 0.022 dctp_c + 0.022 dgtp_c + 0.017 dttp_c + 0.011 gam6p_c + 0.251 gln__L_c + 0.304 glu__L_c + 0.539 gly_c + 0.124 gtp_c + 66.51913 h2o_c + 0.089 his__L_c + 0.199 ile__L_c + 0.005 kdo_c + 0.383 leu__L_c + 0.0204 lipidA_c + 0.239 lys__L_c + 0.053 man1p_c + 0.095 met__L_c + 0.011 murein5px4p_p + 0.01148 pe160_c + 0.02952 pe160_p + 0.00364 pe161_c + 0.00936 pe161_p + 0.00224 pe181_c + 0.00576 pe181_p + 0.001185 pg160_c + 0.001015 pg160_p + 0.000377 pg161_c + 0.000323 pg161_p + 0.000215 pg181_c + 0.000185 pg181_p + 0.211 phe__L_c + 0.191 pro__L_c + 0.444 ser__L_c + 0.265 thr__L_c + 0.066 trp__L_c + 0.0408 ttdca_c + 0.066 tyr__L_c + 0.003 udpg_c + 0.107 utp_c + 0.319 val__L_c --> 71.7 adp_c + 71.7 h_c + 71.7 pi_c + 0.51169 ppi_c Biomass and maintenance functions 0 1000 - Pseudo - - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BIRAH Biuret Amidohydrolase biuret_c + h2o_c --> allphn_c + nh4_c 0 1000 Klebsiella_pneumoniae_INF319_05554 or 16870_7_27_05530 or Klebsiella_pneumoniae_INF319_05552 Catalytic - R05563 rxn03849 2 Biuret introduced to soil by fertilisers meaning plausible degradation reaction in environmental samples. Evidence in Psuedomonas.
BLACT Beta lactamase h2o_c + pencil_c --> h_c + pencilca_c 0 1000 16870_8_1_04918 or K_pneumoniae_NJST258-1_05303 or K_pneumoniae_AR_0148_05297 or Klebsiella_pneumoniae_INF310_05760 or Klebsiella_pneumoniae_INF310_05448 or Klebsiella_pneumoniae_INF359_05092 or K_pneumoniae_AR_0107_05380 or K_pneumoniae_AR_0126_05286 or Klebsiella_variicola_INF345_05535 or KPN_01607 or Klebsiella_pneumoniae_INF310_05444 or 16870_8_84_05068 or Klebsiella_variicola_INF345_05530 or Klebsiella_pneumoniae_INF359_05109 or Klebsiella_pneumoniae_KSB2_2B_05100 Catalytic BLACT R06363 rxn07099 4 Klebsiella known to produce beta-lactamases to break down antibiotics.
BLACTG Beta Lactamase (Penicillin G) h2o_c + peng_c --> bzpeng_c 0 1000 KPN_01607 or Klebsiella_variicola_INF345_05530 or Klebsiella_pneumoniae_INF359_05109 or K_pneumoniae_AR_0126_05286 or K_pneumoniae_AR_0107_05380 or Klebsiella_pneumoniae_INF359_05092 or Klebsiella_variicola_INF345_05535 or 16870_8_84_05068 or AUSMDU00003506_S45_L999_01795 or Klebsiella_pneumoniae_INF310_05444 Catalytic - R04318 rxn11599 4 Klebsiella known to produce beta-lactamases to break down antibiotics.
BLUB Cobalamin biosynthesis fmnh2_c + h2o_c + o2_c --> dmbzid_c + doxopa_c + e4p_c + urea_c Vitamin B12 Metabolism 0 1000 - Catalytic BLUB - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BMOCOS Bis-molybdenum cofactor synthase moco_c + mptamp_c --> amp_c + bmoco_c + cu2_c 0 1000 KPN_00860 Catalytic BMOCOS R09735 rxn16583 3 Know Klebsiella can produce this cofactor (gene KO mutants).
BPNT "3',5'-bisphosphate nucleotidase" h2o_c + pap_c --> amp_c + pi_c 0 1000 KPN_04608 Catalytic BPNT R00188 rxn00137 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information. No gene-protein-rule previously associated with this reaction.
BPNT2 3'-Phospho-5'-adenylyl sulfate 3'-phosphohydrolase h2o_c + paps_c --> aps_c + pi_c 0 1000 KPN_04608 Catalytic - R00508 rxn00360 2 Evidence in E. coli.
BPP Benzoyl phosphate phosphohydrolase bzp_c + h2o_c --> bz_c + pi_c + 3.0 h_c 0 1000 KPN_01004 Catalytic - R01421 rxn01034 2 Evidence in E. coli.
BSORx Biotin sulfoxide reductase btnso_c + h_c + nadh_c --> btn_c + h2o_c + nad_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_03909 Catalytic BSORx - rxn08178 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BSORy Biotin sulfoxide reductase btnso_c + h_c + nadph_c --> btn_c + h2o_c + nadp_c 0 1000 KPN_03909 or KPN_00642 Catalytic BSORy R10127 rxn08179 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BTCOARx Butyryl-coA reductase (NADH) btcoa_c + h_c + nadh_c --> btal_c + coa_c + nad_c 0 1000 16852_1_36_02226 or KPN_02199 or KPN_02118 or Klebsiella_pneumoniae_INF161_04888 Catalytic - R01172 rxn00869 2 Evidence in E. coli.
BTDD_RR R R butanediol dehydrogenase btd_RR_c + nad_c <=> actn__R_c + h_c + nadh_c Butanoate Metabolism -1000 1000 - Catalytic BTDD_RR - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BTDt_RR R R butanediol transport btd_RR_c <=> btd_RR_e Transport -1000 1000 - Transport BTDt_RR - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BTNt2ipp Biotin transport via proton symport (periplasm) btn_p + h_p --> btn_c + h_c 0 1000 - Transport - - - 1 Transport reaction for known Klebsiella biosynthesis product. No genes associated with this reaction.
BTNtex Biotin transport via diffusion (extracellular to periplasm) btn_e <=> btn_p -1000 1000 KPN_02636 or KPN_01445 or KPN_00282 Transport BTNtex - rxn29122 4 Transport reaction for known Klebsiella biosynthesis product.
BTS2 Biotin synthase (ala-L producing) cys__L_c + dtbt_c <=> ala__L_c + btn_c + 2.0 h_c -1000 1000 KPN_00800 Catalytic BTS2 - rxn10089 4 Evidence in E. coli that bioA is part of biotin assembly. Known biosynthesis in Klebsiella.
BTS4 Biotin synthase amet_c + dtbt_c + s_c --> btn_c + dad_5_c + h_c + met__L_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_00800 Catalytic BTS4 - rxn08180 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BTS5 Biotin synthase 2fe2s_c + amet_c + dtbt_c --> 2fe1s_c + btn_c + dad_5_c + h_c + met__L_c 0 1000 KPN_00800 Catalytic BTS5 - - 4 Evidence in E. coli that bioA is part of biotin assembly. Known biosynthesis in Klebsiella.
BUTCT Acetyl-CoA:butyrate-CoA transferase btcoa_c + ac_c <=> but_c + accoa_c -1000 1000 (KPN_02054 and KPN_01538) or (K_africana_200023T_02421 and K_africana_200023T_02422) or (Klebsiella_pneumoniae_kppr1.contigset_00309 and Klebsiella_pneumoniae_KSB2_1C_01466) Catalytic BUTCT R01179 rxn00875 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BUTSO3abcpp Butanesulfonate transport via ABC system (periplasm) atp_c + butso3_p + h2o_c --> adp_c + butso3_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 (KPN_00972 and KPN_00970 and KPN_00969) or (KPN_00311 and KPN_00312 and KPN_00313) Transport BUTSO3abcpp - rxn05512; rxn08181 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BUTSO3tex Butanesulfonate transport via diffusion (extracellular to periplasm) butso3_e <=> butso3_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport BUTSO3tex - rxn08182 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BUTt2rpp Butyrate transport via proton symport reversible (periplasm) but_p + h_p <=> but_c + h_c -1000 1000 16870_8_36_02669 Transport BUTt2rpp - rxn05683 2 Transport reaction to complete the pathway from v1.
BUTtex Butyrate transport via diffusion (extracellular to periplasm) but_e <=> but_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport BUTtex - rxn08184 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BWCOS Tungsten bispterin cofactor synthase mptamp_c + wco_c --> amp_c + bwco_c + cu2_c 0 1000 KPN_00860 Catalytic BWCOS - - 2 Part of Bis-molybdenum cofactor synthesis (evidence of orthologs being found in bacteria).
BYXt Bromoxynil transport bxynil_e <=> bxynil_c -1000 1000 KPN_SPONT Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
BZ12DOX "Benzoate 1,2-dioxygenase" bz_c + h_c + nadh_c + o2_c --> bz12diol_c + nad_c Benzoate degradation 0 1000 KPN_01870 and KPN_01872 and KPN_01871 Catalytic BZ12DOX R05621 rxn03897 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BZALDH Benzyl alcohol dehydrogenase nad_c + bzalc_c --> h_c + nadh_c + bzal_c 0 1000 Klebsiella_variicola_KSB2_3A_05265 or KPN_01945 Catalytic BZALDH R01763 rxn01293 2 xylB gene in P. putida. Evidence that Kp can degrade toluene.
BZDIOLDH "1,2-dihydrodihydroxybenzoate dehydrogenase" bz12diol_c + nad_c --> catechol_c + co2_c + nadh_c Benzoate degradation 0 1000 KPN_01869 Catalytic BZDIOLDH R00813 rxn00584 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
BZHL Benzamide hydro-lyase bznt_c + h2o_c --> bzmd_c 0 1000 Klebsiella_variicola_KSB2_3A_02578 and Klebsiella_variicola_KSB2_3A_02579 Catalytic - R05596 rxn03875 2 Growth evidence in Klebsiella.
BZNTt Benzonitrile transport bznt_e <=> bznt_c -1000 1000 KPN_SPONT Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
BZt Benzoate transport (diffusion) bz_e <=> bz_c Transport -1000 1000 KPN_SPONT Transport BZt - rxn12436 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
C2OGAT Cadaverine 2-oxoglutarate aminotransferase 15dap_c + akg_c --> 5ap_c + glu__L_c + h_c 0 1000 KPN_03501 Catalytic - R12214 - 4 Evidence that Cadaverine can be produced by Klebsiella.
C3C2P1OX Cis-3-chloro-2-propene-1-ol Oxidoreductase c3cl2p1l_c + nad_c --> c3clah_c + nadh_c + h_c 0 1000 Klebsiella_variicola_INF336_05720 or KPN_01952 or KPN_02199 or KPN_01853 or KPN_03491 Catalytic - R05234 rxn14089 2 Evidence in E. coli.
C5MPPRH cytidine-5'-monophosphate phosphoribohydrolase cmp_c + h2o_c + 2.0 h_c --> csn_c + r5p__D_c 0 1000 KPN_03138 Catalytic - R00510 rxn00362 2 Evidence in E. coli.
CA2t3pp Calcium (Ca+2) transport out via proton antiport (periplasm) ca2_c + h_p --> ca2_p + h_c Inorganic Ion Transport and Metabolism 0 1000 KPN_02229 Transport CA2t3pp - rxn05514; rxn08185 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CA2tex Calcium (Ca+2) transport via diffusion (extracellular to periplasm) ca2_e <=> ca2_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport CA2tex - rxn08186 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CADVOX Cadaverine Oxidase 15dap_c + h2o_c + o2_c --> 5ap_c + nh4_c + h2o2_c + h_c 0 1000 KPN_01467 Catalytic - R06740 rxn04571 2 Protein already in the model as CADVtpp and DAPAT (same metabolite different reaction). Evidence in bacteria.
CADVtpp Lysine/Cadaverine antiporter (periplasm) 15dap_c + h_p + lys__L_p --> 15dap_p + h_c + lys__L_c "Transport, Inner Membrane" 0 1000 KPN_00499 Transport CADVtpp - rxn08187; rxn10148 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CAOpp "1,3-Diaminopropane oxidase (periplasm)" 13dampp_p + o2_p + h2o_p --> aproa_p + nh4_p + h2o2_p 0 1000 KPN_01467 Catalytic - R03139 rxn02250 2 Evidence in bacteria.
CAT Catalase 2.0 h2o2_c --> 2.0 h2o_c + o2_c 0 1000 KPN_01236 or KPN_01819 or 16703_7_37_05774 Catalytic CAT R00009 rxn00006 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CAt6pp Calcium / sodium antiporter (1:1) ca2_c + na1_p <=> ca2_p + na1_c Inorganic Ion Transport and Metabolism -1000 1000 KPN_03606 Catalytic CAt6pp - rxn08188; rxn10448 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CATDOX "Catechol 1,2-dioxygenase;" catechol_c + o2_c --> ccmuac_c + 2.0 h_c Benzoate degradation 0 1000 KPN_01873 Catalytic CATDOX R00817 rxn00588 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CBIAT Cobinamide adenyltransferase atp_c + cbi_c + h_c <=> adocbi_c + pppi_c Cofactor and Prosthetic Group Biosynthesis -1000 1000 KPN_01266 Catalytic CBIAT R07268 rxn05029 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CBItonex Cobinamide transport via ton system (extermal) cbi_e + h_p --> cbi_p + h_c "Transport, Outer Membrane" 0 1000 KPN_04255 and KPN_03426 and KPN_02186 and KPN_03425 Transport CBItonex - rxn08190 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CBIuabcpp "Cobinamide transport via ABC system (uptake, periplasm)" atp_c + cbi_p + h2o_c --> adp_c + cbi_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_00173 and KPN_02169 and KPN_02166 Transport CBIuabcpp - rxn08191 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CBL1abcpp Cob(1)alamin transport via ABC system (periplasm) atp_c + cbl1_p + h2o_c --> adp_c + cbl1_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_00173 and KPN_02169 and KPN_02166 Transport CBL1abcpp - rxn08192 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CBL1tonex Cob(1)alamin transport via ton system (extermal) cbl1_e + h_p --> cbl1_p + h_c "Transport, Outer Membrane" 0 1000 KPN_04255 and KPN_03426 and KPN_02186 and KPN_03425 Transport CBL1tonex - rxn08193 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CBLAT Cob(I)alamin adenosyltransferase atp_c + cbl1_c + h_c <=> adocbl_c + pppi_c -1000 1000 KPN_01266 or KPN_02793 or K_quasi_quasi_SB98_05231 Catalytic CBLAT R01492 rxn01084 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CBMD Carbamate deaminase cbm_c + 2.0 h_c --> co2_c + nh4_c 0 1000 KPN_SPONT Catalytic - - - 1 Spontaneous reaction required for UAAH (R09980).
CBMKr Carbamate kinase atp_c + co2_c + nh4_c <=> adp_c + cbp_c + 2.0 h_c -1000 1000 Klebsiella_pneumoniae_INF151_05601 or 16703_5_22_01683 or K_quasi_simil_SB610_05370 or Klebsiella_pneumoniae_INF151_02656 Catalytic CBMKr R00150 rxn00114 2 Catalytic protein/gene identified via genomic analysis in Klebsiella (arcC).
CBPS Carbamoyl-phosphate synthase (glutamine-hydrolysing) 2.0 atp_c + gln__L_c + h2o_c + hco3_c --> 2.0 adp_c + cbp_c + glu__L_c + 2.0 h_c + pi_c Arginine and Proline Metabolism 0 1000 KPN_00040 or KPN_00041 Catalytic CBPS R00575 rxn00414 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CBPt Carbamyl Phosphate transport cbp_e <=> cbp_p -1000 1000 - Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
CBPtpp Carbamyl Phosphate transport (periplasm) cbp_p <=> cbp_c -1000 1000 - Transport - - - 2 Transport reaction for known Klebsiella growth substrate.
CCGS 7-cyano-7-carbaguanine synthase atp_c + cdg_c + nh4_c --> adp_c + h2o_c + h_c + pi_c + preq0_c 0 1000 KPN_00406 or 16870_7_79_00547 Catalytic CCGS R09978 rxn16824 2 Catalytic gene implied in Klebsiella (queC) but have direct evidence in E. coli.
CD2abcpp Cadmium (Cd+2) ABC transporter (periplasm) atp_c + cd2_c + h2o_c --> adp_c + cd2_p + h_c + pi_c Inorganic Ion Transport and Metabolism 0 1000 KPN_03835 Transport CD2abcpp - rxn05516; rxn08195 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CD2t3pp Cadmium (Cd+2) transport out via proton antiport (periplasm) cd2_c + h_p --> cd2_p + h_c Inorganic Ion Transport and Metabolism 0 1000 KPN_00756 or KPN_04222 Transport CD2t3pp - rxn08196; rxn13814 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CD2tex Cadmium (Cd+2) transport via diffusion (extracellular to periplasm) cd2_e <=> cd2_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport CD2tex - rxn08197; rxn08198 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CD2tpp Cadmium (+2) transport in via permease (no H+) cd2_p --> cd2_c Inorganic Ion Transport and Metabolism 0 1000 KPN_03453 Transport CD2tpp - rxn08197; rxn08198 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CDAPPA120 CDP-Diacylglycerol pyrophostatase (n-C12:0) cdpdddecg_c + h2o_c --> cmp_c + 2.0 h_c + pa120_c Glycerophospholipid Metabolism 0 1000 KPN_04007 Catalytic CDAPPA120 - rxn08199 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CDAPPA140 CDP-Diacylglycerol pyrophostatase (n-C14:0) cdpdtdecg_c + h2o_c --> cmp_c + 2.0 h_c + pa140_c Glycerophospholipid Metabolism 0 1000 KPN_04007 Catalytic CDAPPA140 - rxn08200 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CDAPPA141 CDP-Diacylglycerol pyrophostatase (n-C14:1) cdpdtdec7eg_c + h2o_c --> cmp_c + 2.0 h_c + pa141_c Glycerophospholipid Metabolism 0 1000 KPN_04007 Catalytic CDAPPA141 - rxn08201 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CDAPPA160 CDP-Diacylglycerol pyrophostatase (n-C16:0) cdpdhdecg_c + h2o_c --> cmp_c + 2.0 h_c + pa160_c Glycerophospholipid Metabolism 0 1000 KPN_04007 Catalytic CDAPPA160 - rxn08202 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CDAPPA161 CDP-Diacylglycerol pyrophostatase (n-C16:1) cdpdhdec9eg_c + h2o_c --> cmp_c + 2.0 h_c + pa161_c Glycerophospholipid Metabolism 0 1000 KPN_04007 Catalytic CDAPPA161 - rxn08203 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CDAPPA180 CDP-Diacylglycerol pyrophostatase (n-C18:0) cdpdodecg_c + h2o_c --> cmp_c + 2.0 h_c + pa180_c Glycerophospholipid Metabolism 0 1000 KPN_04007 Catalytic CDAPPA180 - rxn08204 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CDAPPA181 CDP-Diacylglycerol pyrophostatase (n-C18:1) cdpdodec11eg_c + h2o_c --> cmp_c + 2.0 h_c + pa181_c Glycerophospholipid Metabolism 0 1000 KPN_04007 Catalytic CDAPPA181 - rxn08205 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CDGR 7-cyano-7-deazaguanine reductase 3.0 h_c + 2.0 nadph_c + preq0_c --> 2.0 nadp_c + preq1_c 0 1000 KPN_03137 Catalytic CDGR R07605 rxn07436 2 Evidence in Bacillus.
CDGS 7-deaza-7-carboxyguanine synthase cph4_c + h_c --> cdg_c + nh4_c 0 1000 KPN_03121 Catalytic - R10002 rxn39964 2 Evidence in E.coli via a protein structure. KPN_03121 has 91% Seq identity to the E. coli protein structure (6NHL) and contains the same functional domains (PF13394.6; PF04055.21). Prior reaction exists in V1 model (CPH4S).
CDI1D D-chiro-inositol 1-dehydrogenase 1dinost_c + nad_c <=> 1kdinost_c + nadh_c + h_c -1000 1000 KPN_04675 or KPN_00507 or 16870_7_82_02737 Catalytic - R09951 rxn16798 2 Evidence in Bacillus.
CDPMEK 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase 4c2me_c + atp_c --> 2p4c2me_c + adp_c + h_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_02237 Catalytic CDPMEK R05634 rxn03908 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CELBpts Cellobiose transport via PEPPyr PTS cellb_e + pep_c --> 6pgg_c + pyr_c 0 1000 KPN_02762 and KPN_02763 and (KPN_03051 or (KPN_01232 and (KPN_01231 or Klebsiella_variicola_KSB2_3A_01375) and (KPN_01230 or Klebsiella_variicola_KSB2_3A_01374))) Transport CELBpts - rxn05518 3 Transport reaction for known Klebsiella growth substrate.
CELLBabc Cellobiose transport via ATP transporter atp_c + cellb_e + h2o_c --> adp_c + cellb_c + h_c + pi_c Transport 0 1000 - Transport CELLBabc - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CELLS Cellulose synthase UDP forming h2o_c + 4.0 udpg_c --> 4.0 h_c + 4.0 udp_c + cell4_p 0 1000 (KPN_03880 and KPN_03883 and KPN_03882) or (KPN_03893 and 16852_1_14_05388 and 16852_1_14_05239) Catalytic CELLS R02889 rxn05800 3 "Part of biofilm production in Klebsiella (KO mutant experiments), E. coli and Salmonella."
CFAS160E "Cyclopropane fatty acid synthase (Phosphatidylethanolamine, n-C16:0)" 2.0 amet_c + pe161_c --> 2.0 ahcys_c + cpe160_c + 2.0 h_c Glycerophospholipid Metabolism 0 1000 KPN_01999 Catalytic CFAS160E - rxn08206 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CFAS160G "Cyclopropane fatty acid synthase (Phosphatidylglycerol, n-C16:0)" 2.0 amet_c + pg161_c --> 2.0 ahcys_c + cpg160_c + 2.0 h_c Glycerophospholipid Metabolism 0 1000 KPN_01999 Catalytic CFAS160G - rxn08207 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CFAS180E "Cyclopropane fatty acid synthase (Phosphatidylethanolamine, n-C18:0)" 2.0 amet_c + pe181_c --> 2.0 ahcys_c + cpe180_c + 2.0 h_c Glycerophospholipid Metabolism 0 1000 KPN_01999 Catalytic CFAS180E - rxn08208 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CFAS180G "Cyclopropane fatty acid synthase (Phosphatidylglycerol, n-C18:0)" 2.0 amet_c + pg181_c --> 2.0 ahcys_c + cpg180_c + 2.0 h_c Glycerophospholipid Metabolism 0 1000 KPN_01999 Catalytic CFAS180G - rxn08209 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CGLYabcpp L-Cysteinylglycine (Cys-Gly) transport via ABC system (periplasm) atp_c + cgly_p + h2o_c --> adp_c + cgly_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_03896 and KPN_03895 and KPN_03899 and KPN_03898 and KPN_03897 Transport CGLYabcpp - rxn05539; rxn08210 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CGLYtex L-Cysteinylglycine transport via diffusion (extracellular to periplasm) cgly_e <=> cgly_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport CGLYtex - rxn08211 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CH4t2pp Methane Transport(periplasm) ch4_c --> ch4_p 0 1000 - Transport CH4t2pp - - 1 Required for Methylphosphonic acid growth simulations but initial matches to model iAPECO1_1312 produced non-specific hits.
CH4tex Methane Transport(extracellular via diffusion) ch4_e <=> ch4_p -1000 1000 - Transport CH4tex - - 1 Transport reaction for substrate that can be simulated by the model (secretion).
CHITOBpts Chitobiose transport via PTS chitob_p + pep_c --> chit6p_c + pyr_c 0 1000 KPN_01232 and KPN_01230 and KPN_01231 and KPN_02762 and KPN_02763 Transport CHITOBpts - rxn27342 4 Protein structure from Klebsiella which shows that Klebsiella can utilise/process this substrate. This means that it must have the ability to be imported in (ie: transport reactions are required).
CHITPH Chitobiose-6-phosphate hydrolase chit6p_c + h2o_c --> acgam6p_c + acgam_c 0 1000 KPN_01234 Catalytic CHITPH - rxn30466 2 Gene is part of operon that ChbG belongs to (which has protein evidence in Klebsiella).
CHLabcpp Choline transport via ABC system (periplasm) atp_c + chol_p + h2o_c --> adp_c + chol_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_02565 and KPN_02566 and KPN_02564 and KPN_02567 Transport CHLabcpp - rxn05159; rxn08212 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CHLt2pp Choline transport via proton symport (periplasm) chol_p + h_p --> chol_c + h_c "Transport, Inner Membrane" 0 1000 KPN_01014 or KPN_00587 Transport CHLt2pp - rxn08213; rxn09692 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CHLtex Choline transport via diffusion (extracellular to periplasm) chol_e <=> chol_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Catalytic CHLtex - rxn08214 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CHMI CHM isomerase chm_c <=> opet_c -1000 1000 KPN_04785 Catalytic CHMI - - 2 Catalytic protein implied in Klebsiella (hpaF) via genomic analysis.
CHMSDH CHMS dehydrogenase chms_c + h2o_c + nad_c --> chm_c + h_c + nadh_c 0 1000 KPN_04787 Catalytic CHMSDH - - 4 Protein has been purified in Klebsiella.
CHOD Cholesterol Oxidase o2_c + chsterol_c --> h2o2_c + chol4en3one_c 0 1000 AH0360_C4PNMANXX_GTAGAGGA-AAGGAGTA_L006_00550 or AH0360_C4PNMANXX_GTAGAGGA-AAGGAGTA_L006_00551 Catalytic CHOD R01459 rxn01064 2 Protein structure from Streptomyces. Evidence in Klebsiella that it can interact with cholestorol (virulence).
CHOLATEtpp Cholate transport via proton antiport cholate_c + h_p --> cholate_p + h_c 0 1000 KPN_04767 Transport CHOLATEtpp - - 2 Evidence in E. coli and catalyses a mechanism for bile salt resistance.
CHOLD Choline dehydrogenase chol_c + nad_c --> betald_c + h_c + nadh_c 0 1000 KPN_00584 or 16852_1_42_04889 Catalytic - R01025 rxn05921 2 Evidence in E. coli.
CHORM Chorismate mutase chor_c --> pphn_c "Tyrosine, Tryptophan, and Phenylalanine Metabolism" 0 1000 KPN_02920 or KPN_02922 Catalytic CHORM R01715 rxn01256 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CHORS Chorismate synthase 3psme_c --> chor_c + pi_c "Tyrosine, Tryptophan, and Phenylalanine Metabolism" 0 1000 KPN_02719 Catalytic CHORS R01714 rxn01255 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CHRPL Chorismate pyruvate lyase chor_c --> 4hbz_c + pyr_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_04427 Catalytic CHRPL R01302 rxn00966 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CHTBSptspp Chitobiose transport via PEP:Pyr PTS (periplasm) chtbs_p + pep_c --> chtbs6p_c + pyr_c 0 1000 KPN_01230 and KPN_01231 and KPN_01232 and KPN_02762 and KPN_02763 Transport CHTBSptspp - - 4 Protein structure from Klebsiella which shows that Klebsiella can utilise this substrate. This means that it must have the ability to be imported in (ie: transport reactions are required).
CHTBStex Chitobiose transport via diffusion (extracellular to periplasm) chtbs_e <=> chtbs_p -1000 1000 KPN_02636 or KPN_01445 or KPN_00282 or KPN_00703 Transport CHTBStex - - 4 Protein structure from Klebsiella which shows that Klebsiella can utilise this substrate. This means that it must have the ability to be imported in (ie: transport reactions are required).
CINNDO Cinnamate dioxygenase cinnm_c + h_c + nadh_c + o2_c --> cenchddd_c + nad_c 0 1000 GCF_003965875.1_ASM396587v1_genomic_01456 and GCF_003965875.1_ASM396587v1_genomic_01460 and GCF_003965875.1_ASM396587v1_genomic_01458 and GCF_003965875.1_ASM396587v1_genomic_01459 Catalytic CINNDO R06783 rxn04598 2 Evidence in E. coli.
CITACt Citrate transport via acetate antiport ac_c + cit_e --> ac_e + cit_c Transport 0 1000 KPN_00055 Transport CITACt - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CITCIa Citramalate dehydratase citm_c --> h2o_c + citac_c 0 1000 (K_quasi_quasi_18A069_01744 and K_quasi_quasi_18A069_01743) or (KPN_00078 and KPN_00077) or (16870_8_84_04763 and 16870_8_84_04762) Catalytic CITCIa R03896 rxn02749 2 Citramalate related to pathogenicity in Yersinia pestis and Psuedomonas.
CITCIb 3-methylmalate hydratase h2o_c + citac_c <=> r3mmal_c -1000 1000 (K_quasi_quasi_18A069_01744 and K_quasi_quasi_18A069_01743) or (KPN_00078 and KPN_00077) or (16870_8_84_04763 and 16870_8_84_04762) Catalytic CITCIb R03898 rxn02751 2 Citramalate related to pathogenicity in Yersinia pestis and Psuedomonas.
CITL Citrate lyase cit_c --> ac_c + oaa_c 0 1000 KPN_00056 and (KPN_00037 or 16870_8_36_04866 or 16870_8_45_02114) and (KPN_00035 or K_quasivariicola_08A119_00505 or Klebsiella_pneumoniae_INF358_04721) and (KPN_00036 or Klebsiella_pneumoniae_INF358_04722 or 16870_8_45_02113) Catalytic CITL R00362 rxn00265 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CITt_kt Citrate proton symport periplasm cit_p + h_p --> cit_c + h_c 0 1000 OCCNDHPP_03496 Transport CITt_kt - - 2 Transport reaction to complete the pathway from v1.
CITt2 Citrate transport in via proton symport cit_e + h_e --> cit_c + h_c 0 1000 OCCNDHPP_03496 Transport CITt2 - rxn05211 2 Transport reaction to complete the pathway from v1.
CITt4_1 Citrate transport via sodium symport cit_e + na1_e --> cit_c + na1_c Pyruvate Metabolism 0 1000 KPN_00033 Catalytic CITt4_1 - rxn30467 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CITt4pp Citrate transport via sodium symport periplasm cit_p + 2.0 na1_p --> cit_c + 2.0 na1_c 0 1000 KPN_00033 Transport CITt4pp - - 2 Know Klebsiella imports citrate using a Na import system which this reaction encodes.
CITtex Citrate transport via diffusion (extracellular to periplasm) cit_e <=> cit_p -1000 1000 KPN_00282 or KPN_01445 or KPN_02636 Transport CITtex - rxn08217 2 Know that Klebsiella can import citrate and therefore must be transported from the extracellular to periplasm environment.
CITtupp Citrate transport periplasm cit_p --> cit_c 0 1000 K_quasi_quasi_SB98_01440 and K_quasi_quasi_U41_01479 and K_quasi_quasi_U41_01478 Transport CITtupp - rxn08217 2 Know Klebsiella can import citrate. Given that this pathway is rare it may be a genuine alternative transporter.
CLB6PH Cellobiose hydrolase cellb6p_c + h2o_c <=> g6p_c + glc__D_c -1000 1000 KPN_02822 or 16870_8_26_05197 or KPN_02577 or 16870_8_26_03859 or Klebsiella_pneumoniae_KSB1_6F_04981 or KPN_03052 or AUSMDU00003500_S10_L001_04837 or Klebsiella_pneumoniae_INF358_03913 or Klebsiella_variicola_INF336_02320 or AH0360_C4PNMANXX_GTAGAGGA-AAGGAGTA_L006_04939 or KPN_03330 or AH0360_C4PNMANXX_GTAGAGGA-AAGGAGTA_L006_04975 or Klebsiella_pneumoniae_INF350_02470 or 16703_5_40_00918 or KPN_01961 or KPN_00847 or 16703_7_12_04888 or KPN_03249 Catalytic CLB6PH R00839 rxn00608 2 Evidence of the alternative beta-glucosidase in Pseudomonas and other gram-negative bacteria (periplasm).
CLBH Cellobiose hydrolase cellb_c + h2o_c --> 2.0 glc__D_c 0 1000 KPN_02822 or 16870_7_82_04749 or AUSMDU00003506_S45_L999_02771 or KPN_02568 or Klebsiella_pneumoniae_INF079_01123 or 16703_7_12_04895 or KPN_01961 Catalytic CLBH R00306 rxn00222 2 Evidence of the alternative beta-glucosidase in Pseudomonas and other gram-negative bacteria (periplasm).
CLBptspp Cellobiose transport via PEPPyr periplasm cellb_p + pep_c --> cellb6p_c + pyr_c 0 1000 KPN_02762 and KPN_02763 and (KPN_03051 or (KPN_01232 and (KPN_01231 or Klebsiella_variicola_KSB2_3A_01375) and (KPN_01230 or Klebsiella_variicola_KSB2_3A_01374))) Transport CLBptspp - - 2 Reaction is encoded by the PTS system. Original gene-protein-rule was incomplete so using the gene-protein-rule from CELBpts as this is complete.
CLBtex Cellobiose transport transport via diffusion extracellular to periplasm cellb_e <=> cellb_p -1000 1000 KPN_00282 or KPN_01445 or KPN_02636 Transport CLBtex - - 2 Part of Klebsiella biofilm meaning this substrate needs to at least be exported.
CLIPAabctex Cold lipid A transport via ABC system (periplasm to extracellular) atp_c + h2o_c + lipa_cold_p --> adp_c + h_c + lipa_cold_e + pi_c 0 1000 KPN_04667 and KPN_04666 and KPN_03609 and KPN_03611 and KPN_03610 and KPN_00051 and KPN_00673 Transport CLIPAabctex - - 2 Exchange reaction already present in iYL1228/V1. Evidence in E. coli. LPS modification genes generally conserved in gram-negative bacteria.
CLIPAt1ex cold Lipid A periplasm transport via vector periplasm to extracellular LptA_p + lipa_cold_p --> lipa_cold_LptA_p 0 1000 (KPN_03611 and KPN_04666 and KPN_04667) or (KPN_03611 and KPN_04666 and KPN_04667 and KPN_03609) Transport CLIPAt1ex - - 4 Exchange reaction already present in iYL1228/V1. Evidence in E. coli. LPS modification genes generally conserved in gram-negative bacteria with Klebsiella protein structure available.
CLIPAt2ex cold Lipid A transport via vector periplasm to extracellular lipa_cold_LptA_p --> LptA_p + lipa_cold_e 0 1000 KPN_00051 and KPN_00673 Transport CLIPAt2ex - - 4 Exchange reaction already present in iYL1228/V1. Evidence in E. coli. LPS modification genes generally conserved in gram-negative bacteria and Klebsiella structure available.
CLIPAtex Cold lipid A transport via vector (periplasm to extracellular) lipa_cold_p --> lipa_cold_e Lipopolysaccharide Biosynthesis / Recycling 0 1000 - Transport CLIPAtex - rxn08218 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLPNH120pp "Cardiolipin hydrolase (periplasm, n-C12:0)" clpn120_p + h2o_p --> h_p + pa120_p + pg120_p Fatty Acid Biosynthesis 0 1000 - Catalytic CLPNH120pp - rxn08219 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLPNH140pp "Cardiolipin hydrolase (periplasm, n-C14:0)" clpn140_p + h2o_p --> h_p + pa140_p + pg140_p Fatty Acid Biosynthesis 0 1000 - Catalytic CLPNH140pp - rxn08220 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLPNH141pp "Cardiolipin hydrolase (periplasm, n-C14:1)" clpn141_p + h2o_p --> h_p + pa141_p + pg141_p Fatty Acid Biosynthesis 0 1000 - Catalytic CLPNH141pp - rxn08221 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLPNH160pp "Cardiolipin hydrolase (periplasm, n-C16:0)" clpn160_p + h2o_p --> h_p + pa160_p + pg160_p Fatty Acid Biosynthesis 0 1000 - Catalytic CLPNH160pp - rxn08222 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLPNH161pp "Cardiolipin hydrolase (periplasm, n-C16:1)" clpn161_p + h2o_p --> h_p + pa161_p + pg161_p Fatty Acid Biosynthesis 0 1000 - Catalytic CLPNH161pp - rxn08223 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLPNH180pp "Cardiolipin hydrolase (periplasm, n-C18:0)" clpn180_p + h2o_p --> h_p + pa180_p + pg180_p Fatty Acid Biosynthesis 0 1000 - Catalytic CLPNH180pp - rxn08224 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLPNH181pp "Cardiolipin hydrolase (periplasm, n-C18:1)" clpn181_p + h2o_p --> h_p + pa181_p + pg181_p Fatty Acid Biosynthesis 0 1000 - Catalytic CLPNH181pp - rxn08225 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLPNS120pp Cardiolipin synthase (periplasmic_ n-C12:0) 2.0 pg120_p <=> clpn120_p + glyc_p -1000 1000 KPN_00817 or KPN_02190 or Klebsiella_variicola_KSB1_10B_05341 Catalytic CLPNS120pp R07390 rxn08226 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLPNS140pp Cardiolipin synthase (periplasmic_ n-C14:0) 2.0 pg140_p <=> clpn140_p + glyc_p -1000 1000 KPN_00817 or KPN_02190 or Klebsiella_variicola_KSB1_10B_05341 Catalytic CLPNS140pp R07390 rxn08227 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLPNS141pp Cardiolipin synthase (periplasmic_ n-C14:1) 2.0 pg141_p <=> clpn141_p + glyc_p -1000 1000 KPN_00817 or KPN_02190 or Klebsiella_variicola_KSB1_10B_05341 Catalytic CLPNS141pp R07390 rxn08228 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLPNS160pp Cardiolipin synthase (periplasmic_ n-C12:0) 2.0 pg160_p <=> clpn160_p + glyc_p -1000 1000 KPN_00817 or KPN_02190 or Klebsiella_variicola_KSB1_10B_05341 Catalytic CLPNS160pp R07390 rxn08229 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLPNS161pp Cardiolipin synthase (periplasmic_ n-C16:1) 2.0 pg161_p <=> clpn161_p + glyc_p -1000 1000 KPN_00817 or KPN_02190 or Klebsiella_variicola_KSB1_10B_05341 Catalytic CLPNS161pp R07390 rxn08230 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLPNS180pp Cardiolipin synthase (periplasmic_ n-C18:0) 2.0 pg180_p <=> clpn180_p + glyc_p -1000 1000 KPN_00817 or KPN_02190 or Klebsiella_variicola_KSB1_10B_05341 Catalytic CLPNS180pp R07390 rxn08231 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLPNS181pp Cardiolipin synthase (periplasmic_ n-C18:1) 2.0 pg181_p <=> clpn181_p + glyc_p -1000 1000 KPN_00817 or KPN_02190 or Klebsiella_variicola_KSB1_10B_05341 Catalytic CLPNS181pp R07390 rxn08232 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLt3_2pp Chloride transport out via proton antiport (2:1) (periplasm) 2.0 cl_p + h_c --> 2.0 cl_c + h_p Inorganic Ion Transport and Metabolism 0 1000 KPN_00170 or KPN_01576 Transport CLt3_2pp - rxn08233 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CLtex Chloride (Cl-1) transport via diffusion (extracellular to periplasm) cl_e <=> cl_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport CLtex - rxn08234; rxn10473 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CMCMSAD 4 carboxy 2 hydroxymuconate 6 semialdehyde dehydrogenase 5cmhmsa_c + h2o_c + nad_c --> 5cmhm_c + 2.0 h_c + nadh_c Tyrosine metabolism 0 1000 KPN_04787 Catalytic CMCMSAD R04418 rxn03055 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CMDDH6 Cyclomaltodextrin dextrin-hydrolase (N=6) acdextrin_c + h2o_c --> mdextrin6_c 0 1000 16870_8_44_05056 Catalytic CMDDH6 R03122 rxn06316 4 Protein purification evidence in K. oxytoca suggested that Cyclodextrin can be broken down into maltose and maltotriose.
CMDDH8 Cyclomaltodextrin dextrin-hydrolase (N=8) gcdextrin_c + h2o_c --> mdextrin8_c 0 1000 16870_8_44_05056 Catalytic CMDDH8 R03122 rxn06316 4 Protein purification evidence in K. oxytoca suggested that Cyclodextrin can be broken down into maltose and maltotriose.
CMDGT6 Cyclomaltodextrin glucanotransferase (N=6) 6.0 glycogen_c --> acdextrin_c 0 1000 AUSMDU00003507_S55_L999_05038 Catalytic - R11260 - 4 Evidence in Klebsiella that this pathway can be utilised.
CMDGT8 Cyclomaltodextrin glucanotransferase (N=8) 8.0 glycogen_c --> gcdextrin_c 0 1000 AUSMDU00003507_S55_L999_05038 Catalytic - R11260 - 4 Evidence in Klebsiella that this pathway can be utilised.
CMHMI 5 carboxymethyl 2 hydroxymuconate delta isomerase 5cmhm_c <=> 5cohe_c -1000 1000 KPN_04785 or 16870_7_23_00537 Catalytic CMHMI R04379 rxn03040 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CMLBL CARBOXYMETHYLENEBUTENOLIDASE-RXN 4cnbt_c + h2o_c --> h_c + malac_c 0 1000 KPN_04326 or KPN_03421 or 16870_8_42_00192 Catalytic - R03893 rxn02747 2 Evidence in E. coli.
CMPtex CMP transport via diffusion (extracellular to periplasm) cmp_e <=> cmp_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport CMPtex - rxn08236; rxn09776 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CMt2ppi Chloramphenicol transport via diffusion periplasm to cytosol cm_p --> cm_c 0 1000 - Transport - - - 1 Transport reaction for known Klebsiella growth degradation product. No gene sequence associated with the reaction.
CMtex Chloramphenicol transport via diffusion (extracellular to periplasm) cm_e <=> cm_p -1000 1000 KPN_02636 or KPN_01445 or KPN_00282 Transport CMtex - - 2 Transport reaction for known Klebsiella growth degradation product.
CMtpp Chloramphenicol transport via TolC system cm_p + h_p --> cm_e + h_c 0 1000 (KPN_00444 and KPN_03449 and KPN_02803) or (KPN_00444 and KPN_03449 and KPN_00443) Transport CMtpp - - 2 Transport reaction for known Klebsiella growth degradation product.
CMXN3D Caffeine Methylxanthine N3-demethylase caffeine_c + nadph_c + o2_c + h_c --> 17dmxan_c + nadp_c + fald_c + h2o_c 0 1000 Klebsiella_pneumoniae_KSB2_1B_04894 Catalytic - R07939 rxn07729 2 Protein evidence in bacteria/Pseudomonas putida. Degradation pathway.
CO2tex CO2 transport via diffusion (extracellular to periplasm) co2_e <=> co2_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport CO2tex - rxn05467; rxn08237; rxn08238; rxn09706; rxn09775; rxn09821; rxn09860; rxn09876 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CO2tpp CO2 transporter via diffusion (periplasm) co2_p <=> co2_c "Transport, Inner Membrane" -1000 1000 KPN_SPONT Transport CO2tpp - rxn05467; rxn08237; rxn08238; rxn09706; rxn09775; rxn09821; rxn09860; rxn09876 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
COB1NDAAT1 Cob I yrinate a c diamide adenosyltransferase 1 atp_c + cob1nda_c + h_c <=> adcob1nda_c + pppi_c -1000 1000 K_quasi_quasi_18A069_00898 or KPN_01266 or K_quasi_quasi_SB98_05231 or KPN_03215 or KPN_03492 Catalytic COB1NDAAT1 R07268 rxn05029 2 Evidence in Salmonella. Protein is from the eut operon that Klebsiella is known to carry.
COB1NDAAT2 Cob I yrinate a c diamide adenosyltransferase 2 atp_c + cob1nda_c + h2o_c --> adcob1nda_c + pi_c + ppi_c 0 1000 KPN_02793 Catalytic COB1NDAAT2 - - 2 Evidence in Salmonella. Protein is from the eut operon that Klebsiella is known to carry.
COBALT2abcpp Cobalt (Co+2) ABC transporter (periplasm) atp_c + cobalt2_c + h2o_c --> adp_c + cobalt2_p + h_c + pi_c 0 1000 (KPN_03188 and KPN_03187 and KPN_03185 and 16703_5_22_02256) or KPN_03835 Transport COBALT2abcpp - rxn08239 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
Cobalt2abcppI Cobalt II transport via ABC system periplasm I atp_c + cobalt2_p + h2o_c --> adp_c + cobalt2_c + h_c + pi_c 0 1000 KPN_03188 and KPN_03187 and 16703_5_22_02256 and KPN_03185 Transport Cobalt2abcppI - rxn05166 2 Transport reaction to complete the pathways/provide alternate pathway from V1.
COBALT2t3pp Cobalt (Co+2) transport out via proton antiport (periplasm) cobalt2_c + h_p --> cobalt2_p + h_c Inorganic Ion Transport and Metabolism 0 1000 KPN_04222 or KPN_00756 Transport COBALT2t3pp - rxn08240; rxn13681 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
COBALT2tex Cobalt (Co+2) transport via diffusion (extracellular to periplasm) cobalt2_e <=> cobalt2_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport COBALT2tex - rxn08241; rxn08242; rxn10474 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
COBALT2tpp Cobalt transport in via permease (no H+) cobalt2_p --> cobalt2_c Inorganic Ion Transport and Metabolism 0 1000 KPN_03453 or KPN_04313 Transport COBALT2tpp - rxn08241; rxn08242; rxn10474 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
COBALT2tpp_copy2 Cobalt transport in via permease (no H+) cobalt2_p <=> cobalt2_c -1000 1000 KPN_03188 and KPN_03187 Transport - - rxn08241 2 Evidence that Klebsiella can develop cobalt resistance which implies it can be imported into the cell.
CODSCL4MT Cobalt precorrin 4 methyltransferase amet_c + copre4_c --> ahcys_c + codscl5a_c + h_c 0 1000 KPN_03194 Catalytic CODSCL4MT R05810 rxn04048 2 Cobalt precorrin genes have been identified through Klebsiella genomic analyses.
CODSCL5BMT Cobalt precorrin 5b methyltransferase amet_c + codscl5b_c --> ahcys_c + copre6_c + h_c 0 1000 KPN_03197 Catalytic CODSCL5BMT R07773 rxn07587 2 Cobalt precorrin genes have been identified through Klebsiella genomic analyses.
CODSCL5DA Cobalt precorrin 5a deacetylation codscl5a_c + h2o_c --> acald_c + codscl5b_c + h_c 0 1000 16703_5_22_02263 Catalytic CODSCL5DA R07772 rxn07586 2 Cobalt precorrin genes have been identified through Klebsiella genomic analyses.
CODSCL6BMT Cobalt precorrin 6b methyltransferase amet_c + codhpre6_c --> ahcys_c + codscl7_c + h_c 0 1000 KPN_03196 or Kqq_0005_BV or KPN_03195 Catalytic CODSCL6BMT R07774 rxn07588 2 Cobalt precorrin genes have been identified through Klebsiella genomic analyses.
CODSCL7MTDC Cobalt precorrin 7 methyltransferase decarboxylase amet_c + codscl7_c --> ahcys_c + co2_c + codscl8x_c 0 1000 Kqq_0005_BV or Kqq_0004_BV Catalytic CODSCL7MTDC R07775 rxn07589 2 Cobalt precorrin genes have been identified through Klebsiella genomic analyses.
CODSCL8XI Cobalt precorrin 8x isomerase codscl8x_c <=> cobya_c -1000 1000 K_quasi_quasi_SB98_00892 Catalytic CODSCL8XI R05814 rxn04052 2 Cobalt precorrin genes have been identified through Klebsiella genomic analyses.
COLIPAabcpp Core oligosaccharide lipid A transport via ABC system (periplasm) atp_c + colipa_c + h2o_c --> adp_c + colipa_p + h_c + pi_c Lipopolysaccharide Biosynthesis / Recycling 0 1000 KPN_00941 Transport COLIPAabcpp - rxn08243 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
COLIPAabctex Core oligosaccharide lipid A transport via ABC system (periplasm to extracellular) atp_c + colipa_p + h2o_c --> adp_c + colipa_e + h_c + pi_c 0 1000 KPN_00673 and KPN_03610 and KPN_04667 and KPN_03611 and KPN_03609 and KPN_00051 and KPN_04666 Transport COLIPAabctex - - 2 Exchange reaction already present in iYL1228/V1. Evidence in E. coli. LPS modification genes generally conserved in gram-negative bacteria.
COLIPAt1ex core oligosaccharide lipid A transport via vector periplasm to extracellular LptA_p + colipa_p --> colipa_LptA_p 0 1000 (KPN_03611 and KPN_04666 and KPN_04667) or (KPN_03611 and KPN_04666 and KPN_04667 and KPN_03609) Transport COLIPAt1ex - - 4 Exchange reaction already present in iYL1228/V1. Evidence in E. coli. LPS modification genes generally conserved in gram-negative bacteria with Klebsiella protein structure available.
COLIPAt2ex core oligosaccharide lipid A transport via vector periplasm to extracellular colipa_LptA_p --> LptA_p + colipa_e 0 1000 KPN_00051 and KPN_00673 Transport COLIPAt2ex - - 4 Exchange reaction already present in iYL1228/V1. Evidence in E. coli. LPS modification genes generally conserved in gram-negative bacteria and Klebsiella structure available.
CPC2MT Precorrin-2 C20-methyltransferase amet_c + copre2_c --> ahcys_c + copre3_c + h_c Vitamin B12 Metabolism 0 1000 KPN_03189 Catalytic CPC2MT - rxn04046 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CPC3MT Precorrin-3B C17-methyltransferase amet_c + copre3_c --> ahcys_c + copre4_c Vitamin B12 Metabolism 0 1000 KPN_03192 Catalytic CPC3MT R05809 rxn04047 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CPC4MT Precorrin-4 C11-methyltransferase amet_c + copre4_c --> ahcys_c + copre5_c + h_c Vitamin B12 Metabolism 0 1000 KPN_03194 Catalytic CPC4MT R05810 rxn04048 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CPC5MT Precorrin-5 C1-methyltransferase amet_c + copre5_c + h2o_c --> acald_c + ahcys_c + copre6_c + h_c Vitamin B12 Metabolism 0 1000 KPN_03193 and KPN_03197 Catalytic CPC5MT R05811 rxn04049 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CPC6MT "Precorrin-6Y C5,15-methyltransferase (decarboxylating)" 2.0 amet_c + codhpre6_c --> 2.0 ahcys_c + co2_c + copre8_c + h_c Vitamin B12 Metabolism 0 1000 (KPN_03196 and KPN_03195) or (Kqq_0004_BV and Kqq_0005_BV) Catalytic CPC6MT R05813 rxn04051 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CPC6R Precorrin-6A reductase copre6_c + h_c + nadph_c --> codhpre6_c + nadp_c 0 1000 KPN_03191 or 16703_5_22_02261 Catalytic CPC6R R05812 rxn04050 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CPC8MM Precorrin-8X methylmutase copre8_c <=> cobya_c Vitamin B12 Metabolism -1000 1000 KPN_03198 Catalytic CPC8MM R05814 rxn04052 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CPGNabcpp Coprogen transport via ABC system (periplasm) atp_c + cpgn_p + h2o_c --> adp_c + cpgn_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_00166 and KPN_00167 and KPN_00168 Transport CPGNabcpp - rxn08245 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CPH4S "6-carboxy-5,6,7,8-tetrahydropterin synthase" ahdt_c + h2o_c --> acald_c + cph4_c + h_c + pppi_c 0 1000 KPN_03120 Catalytic CPH4S R09959 rxn16806 2 Evidence in Bacillus.
CPK1 Adenylate kinase cmp_c + ctp_c <=> 2.0 cdp_c -1000 1000 KPN_00456 Catalytic CPK1 - - 2 Indirect evidence of catalytic protein in Klebsiella (as a reporter of bacterial lysis).
CPL Carbon-phosphorous lyase prpmn_c --> ch4_c + prcp_c 0 1000 KPN_04496 or Klebsiella_pneumoniae_INF237_05279 Catalytic CPL R10204 rxn40081 2 Evidence in E. coli. Evidence that K. aerogenes can encode the phn operon.
CPMPS Cyclic pyranopterin monophosphate synthase gtp_c + h2o_c --> cpmp_c + ppi_c 0 1000 KPN_00812 and KPN_00810 Catalytic CPMPS - - 2 Evidence of these genes and reaction in Klebsiella.
CPMPS_1 Cyclic pyranopterin monophosphate synthase h2o_c + 38ch2gtp_c --> cpmp_c + ppi_c 0 1000 KPN_00812 Catalytic CPMPS_1 R11372 - 2 Evidence of these genes and reaction in Klebsiella.
CPOAT CHLORAMPHENICOL-O-ACETYLTRANSFERASE-RXN coa_c + cm3ac_c <=> accoa_c + cm_c -1000 1000 Klebsiella_pneumoniae_INF359_05176 or Klebsiella_pneumoniae_INF174_05079 or KPN_02018 Catalytic CPOAT R03065 rxn02199 2 Know that Klebsiell can develop resistance to chloramphenicol.
CPPPGO Coproporphyrinogen oxidase (O2 required) cpppg3_c + 2.0 h_c + o2_c --> 2.0 co2_c + 2.0 h2o_c + pppg9_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_02779 Catalytic CPPPGO R03220 rxn02303; rxn12220 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CPPPGO2 Oxygen Independent coproporphyrinogen-III oxidase 2.0 amet_c + cpppg3_c --> 2.0 co2_c + 2.0 dad_5_c + 2.0 met__L_c + pppg9_c Cofactor and Prosthetic Group Biosynthesis 0 1000 KPN_04175 or KPN_03389 Catalytic CPPPGO2 R06895 rxn04704 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CREAT Creatinase h2o_c + creat_c --> sarcs_c + urea_c 0 1000 K_quasi_quasi_U41_03959 Catalytic CREAT R01566 rxn01142 2 Evidence in Psuedomanas and Klebsiella plasmid. Homodimer (OR statement). Creatine would come from the host and can't be produced by Klebsiella.
CREATtex Creatine transport via diffusion extracellular to periplasm creat_e <=> creat_p -1000 1000 - Transport - - - 1 Bacterial creatinase has been recorded on plasmids in clinical KpSC isolates. Known nitrogen source in Pseudomonas.
CREATtpp Creatine transport via proton symport reversible periplasm h_p + creat_p <=> h_c + creat_c -1000 1000 - Transport CREATtpp - - 1 Pseudo-reaction to allow Klebsiella to simulate growth on creatine. Evidence in Psuedomanas and Klebsiella plasmid. Homodimer (OR statement). Creatine would come from the host and can't be produced by Klebsiella.
CRNabcpp L-carnitine transport via ABC system (periplasm) atp_c + crn_p + h2o_c --> adp_c + crn_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_03008 and KPN_03009 and KPN_03010 Transport CRNabcpp - rxn05180; rxn08253 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CRNDabcpp D-carnitine transport via ABC system (periplasm) atp_c + crn__D_p + h2o_c --> adp_c + crn__D_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_03009 and KPN_03008 and KPN_03010 Transport CRNDabcpp - rxn08259 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CRNDt2rpp D-carnitine outward transport (H+ antiport) crn__D_p + h_p <=> crn__D_c + h_c "Transport, Inner Membrane" -1000 1000 KPN_04503 Transport CRNDt2rpp - rxn08261 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CRNt2rpp L-carnitine outward transport (H+ antiport) crn_p + h_p <=> crn_c + h_c "Transport, Inner Membrane" -1000 1000 KPN_04503 Transport CRNt2rpp - rxn08262; rxn12605 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CRNtex L-carnitine transport via diffusion (extracellular to periplasm) crn_e <=> crn_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport CRNtex - rxn08265; rxn09691; rxn09773; rxn09858 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CRTNh Creatinine amidohydrolase h2o_c + crtn_c <=> creat_c -1000 1000 16852_1_32_05055 or KPN_02038 or 16870_8_8_04785 Catalytic - R01884 rxn01374 2 Evidence in Pseudomonas. Inhibits bacterial replication.
CRTNIH Creatinine iminohydrolase h_c + h2o_c + crtn_c --> nh4_c + mthd_c 0 1000 KPN_00632 or KPN_03751 or K_quasi_simil_SB610_05367 or KPN_02036 Catalytic - R02922 rxn02090 2 Evidence in E. coli.
CS Citrate synthase accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c 0 1000 KPN_00727 or KPN_00489 Catalytic CS R00351 rxn00256 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CSND Cytosine deaminase csn_c + h_c + h2o_c --> nh4_c + ura_c 0 1000 KPN_03751 or KPN_00632 or K_quasi_simil_SB610_05367 or KPN_02036 Catalytic CSND R00974 rxn00717 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CSNt2pp Cytosine transport in via proton symport (periplasm) csn_p + h_p --> csn_c + h_c "Transport, Inner Membrane" 0 1000 KPN_00633 Transport CSNt2pp - rxn05527 rxn08266 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CSNtex Cytosine transport via diffusion (extracellular to periplasm) csn_e <=> csn_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport CSNtex - rxn08267 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CTBTabcpp Crotonobetaine transport via ABC system (periplasm) atp_c + ctbt_p + h2o_c --> adp_c + ctbt_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_03008 and KPN_03009 and KPN_03010 Transport CTBTabcpp - rxn05192 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CTBTt2rpp Cronobetaine outward transport (H+ antiport) ctbt_p + h_p <=> ctbt_c + h_c "Transport, Inner Membrane" -1000 1000 KPN_04503 Transport CTBTt2rpp - rxn08270 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CTECOAI6 3-cis-2-trans-enoyl-CoA isomerase tdecoa_c --> td2coa_c Membrane Lipid Metabolism 0 1000 KPN_04340 Catalytic CTECOAI6 - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CTECOAI7 3-cis-2-trans-enoyl-CoA isomerase hdcoa_c --> hdd2coa_c Membrane Lipid Metabolism 0 1000 KPN_04340 Catalytic CTECOAI7 - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CTECOAI8 3-cis-2-trans-enoyl-CoA isomerase odecoa_c --> od2coa_c Membrane Lipid Metabolism 0 1000 KPN_04340 Catalytic CTECOAI8 - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CTLSE Cinnavalininate Catalase 2.0 o2_c + 2.0 3hanthrn_c --> 2.0 h2o2_c + cvn_c + 2.0 h_c 0 1000 KPN_01236 or 16703_7_37_05774 or KPN_01819 Catalytic - R02670 rxn06212 2 Evidence in E. coli.
CTPS1 CTP synthase NH3 atp_c + nh4_c + utp_c --> adp_c + ctp_c + 2.0 h_c + pi_c 0 1000 KPN_03124 Catalytic CTPS1 R00571 rxn00410 2 Evidence in Lactococcus lactis.
CTPS2 CTP synthase (glutamine) atp_c + gln__L_c + h2o_c + utp_c --> adp_c + ctp_c + glu__L_c + 2.0 h_c + pi_c Purine and Pyrimidine Biosynthesis 0 1000 KPN_03124 Catalytic CTPS2 R00573 rxn00412; rxn11276 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CU1abcpp Copper (Cu +1) ABC transporter (periplasm) atp_c + cu_c + h2o_c --> adp_c + cu_p + h_c + pi_c Inorganic Ion Transport and Metabolism 0 1000 KPN_00464 Transport CU1abcpp - rxn05528 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CU1Opp Cuprous Oxidase (Cu+1) 4.0 cu_p + 4.0 h_p + o2_p --> 4.0 cu2_p + 2.0 h2o_p Inorganic Ion Transport and Metabolism 0 1000 KPN_00131 Catalytic CU1Opp - rxn08272 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CU2abcpp Copper (Cu+2) ABC transporter (periplasm) atp_c + cu2_c + h2o_c --> adp_c + cu2_p + h_c + pi_c 0 1000 KPN_03835 or 16703_5_13_05294 Transport CU2abcpp - rxn05528 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CU2tex Copper (Cu+2) transport via diffusion (extracellular to periplasm) cu2_e <=> cu2_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport CU2tex - rxn05212; rxn08273; rxn08274 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CU2tpp Copper transport in via permease (no H+) cu2_p --> cu2_c Inorganic Ion Transport and Metabolism 0 1000 KPN_03453 Transport CU2tpp - rxn05212; rxn08273; rxn08274 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CURR NADPH-dependent curcumin reductase cur_c + h_c + nadph_c --> dhcur_c + nadp_c 0 1000 KPN_01913 Catalytic CURR - - 2 Evidence in E. coli and intestinal bacteria. Potential antimicrobial in Klebsiella meaning this reaction could be a potential resistance mechanism.
CUt2pp Copper transport out via permease (no H+) cu_c --> cu_p 0 1000 KPN_03691 or KPN_00446 or 16703_5_22_00685 or KPN_00543 or KPN_04556 or KPN_03353 or KPN_00837 Transport CUt2pp - - 2 Export transport reaction.
CUt3 Copper transport out via proton antiport cu_c + h_e --> cu_e + h_c "Transport, Outer Membrane" 0 1000 KPN_04738 and KPN_04736 and KPN_04737 and KPN_04739 Transport CUt3 - rxn08275 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CUtex Copper (Cu+1) transport via diffusion (extracellular to periplasm) cu_e <=> cu_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport CUtex - rxn29147 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CXSAMS Carboxy-S-adenosyl-L-methionine synthase amet_c + pphn_c --> cxsam_c + h2o_c + phpyr_c 0 1000 KPN_02384 Catalytic CXSAMS - - 2 Evidence in Salmonella.
CYANAAH Cyanuric acid amidohydrolase cyanac_c + h2o_c --> 1carbxyb_c 0 1000 K_quasi_quasi_SB1124_05178 or K_quasi_simil_SB610_05371 Catalytic - - - 3 Gene mutant KO evidence in Klebsiella.
CYANST Cyanide sulfurtransferase cyan_c + tsul_c --> h_c + so3_c + tcynt_c Unassigned 0 1000 KPN_03791 Catalytic CYANST R01931 rxn01416 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYANSTpp Cyanide sulfurtransferase (periplasmic) cyan_p + tsul_p --> h_p + so3_p + tcynt_p 0 1000 KPN_01213 or KPN_02851 or KPN_03791 Transport CYANSTpp R01931 rxn01416 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYANtex Cyanide transport via diffusion (extracellular to periplasm) cyan_e <=> cyan_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport CYANtex - rxn08276 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYNTAH Cyanate aminohydrolase cynt_c + 3.0 h_c + hco3_c --> 2.0 co2_c + nh4_c 0 1000 16852_1_38_05353 Catalytic CYNTAH R10079 rxn08277 2 Evidence in cyanobacteria. Klebsiella can biodegrade cyanide.
CYNTt2pp Cyanate transport via proton symport (periplasm) cynt_p + h_p --> cynt_c + h_c "Transport, Inner Membrane" 0 1000 KPN_02734 Transport CYNTt2pp - rxn08278; rxn10132 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYNTtex Cyanate transport via diffusion (extracellular to periplasm) cynt_e <=> cynt_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport CYNTtex - rxn08279 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYRDAAT "Cob(I)yrinic acid a,c-diamide adenosyltransferase" atp_c + h_c + co1dam_c --> pppi_c + adcobdam_c -1000 1000 KPN_01266 or K_quasi_quasi_18A069_00898 or KPN_01266 or K_quasi_quasi_SB98_05231 or KPN_03215 or KPN_03492 Catalytic COB1NDAAT1 R05220 rxn03535 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYRDAR2 "Cob(II)yrinic acid a,c-diamide reductase (fmn-dependent)" 2.0 co2dam_c + fmnh2_c --> 2.0 co1dam_c + fmn_c + 2.0 h_c Vitamin B12 Metabolism 0 1000 - Catalytic CYRDAR2 R05218 - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYRDAS "Cob(II)yrinate a,c-diamide synthase (glutamine-hydrolysing)" 2.0 atp_c + cobya_c + 2.0 gln__L_c + h2o_c --> 2.0 adp_c + co2dam_c + 2.0 glu__L_c + h_c + ppi_c 0 1000 16703_5_22_02270 Catalytic CYRDAS - rxn10483 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information. No gene-protein-rule previously associated with this reaction.
CYS L-cysteine h2s_c + ser__L_c <=> cys__L_c + h2o_c "Glycine, Serine and threonine metabolism" -1000 1000 KPN_03409 Catalytic CYS R01287; R00891 rxn00952; rxn05909 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYSabc2pp L-cysteine export via ABC system (cytoplasm to periplasm) atp_c + cys__L_c + h2o_c --> adp_c + cys__L_p + h_c + pi_c "Transport, Inner Membrane" 0 1000 KPN_00919 and KPN_00918 Transport CYSabc2pp - rxn08280 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYSabcpp L-cysteine uptake via ABC system (periplasm) atp_c + cys__L_p + h2o_c --> adp_c + cys__L_c + h_c + pi_c 0 1000 KPN_02416 and KPN_02418 and KPN_02415 Transport CYSabcpp - rxn05237 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information. No gene-protein-rule previously associated with this reaction.
CYSDabcpp D-cysteine uptake via ABC system (periplasm) atp_c + cys__D_p + h2o_c --> adp_c + cys__D_c + h_c + pi_c "Transport, Inner Membrane" 0 1000 - Transport CYSDabcpp - rxn08282 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYSDDS D-cysteine desulfhydrase cys__D_c + h2o_c --> h2s_c + nh4_c + pyr_c Cysteine Metabolism 0 1000 KPN_02417 Catalytic CYSDDS R01874 rxn01365 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYSDS Cysteine Desulfhydrase cys__L_c + h2o_c --> h2s_c + nh4_c + pyr_c 0 1000 KPN_03428 or AH0360_C4PNMANXX_GTAGAGGA-AAGGAGTA_L006_00538 or KPN_03410 or KPN_03428 or KPN_04233 or Klebsiella_pneumoniae_INF310_05280 or Klebsiella_pneumoniae_KSB2_9B_05036 or KPN_01511 Catalytic CYSDS R00782 rxn00566 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYSDSF Cysteine desulfurase cys__L_c <=> ala__L_c + s_c -1000 1000 KPN_02862 Catalytic CYSDSF R11528 - 2 Direct evidence in E. coli. Known as NifS in Klebsiella.
CYSDtex D-cysteine transport via diffusion (extracellular to periplasm) cys__D_e <=> cys__D_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport CYSDtex - rxn08283 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYSIabcpp L cystine uptake via ABC system periplasm atp_c + h2o_c + cysi__L_p --> adp_c + h_c + pi_c + cysi__L_c 0 1000 - Transport - - - 1 Transport reaction for substrate that can be simulated by the model.
CYSItex L cystine transport via diffusion extracellular to periplasm cysi__L_e <=> cysi__L_p -1000 1000 KPN_00282 or KPN_01445 or KPN_02636 Transport CYSItex - rxn42783 2 Evidence that Klebsiella can import L-cystine from media.
CYSItpp Cystine efflux transport cysi__L_c --> cysi__L_p 0 1000 KPN_04240 Transport CYSItpp - - 2 Evidence that Klebsiella can import L-cystine from media.
CYSLYSL L-Cystine Lysteine-lyase (deaminating) h2o_c + cysi__L_c --> nh4_c + pyr_c + thcys_c 0 1000 AH0360_C4PNMANXX_GTAGAGGA-AAGGAGTA_L006_00538 or KPN_03410 or KPN_03428 or KPN_04233 or Klebsiella_pneumoniae_INF310_05280 or Klebsiella_pneumoniae_KSB2_9B_05036 or KPN_01511 Catalytic - R02408 rxn01735 2 Evidence in E. coli.
CYSS Cysteine synthase acser_c + h2s_c --> ac_c + cys__L_c + h_c Cysteine Metabolism 0 1000 KPN_02769 or KPN_02761 or KPN_00409 Catalytic CYSS R00897 rxn00649 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYSSADS L-cysteine sulfinic acid desulfurase 3sala_c + 2.0 h_c --> ala__L_c + so2_c Cysteine Metabolism 0 1000 KPN_03161 Catalytic CYSSADS R00863 rxn00624 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYSTA Cysteine transaminase akg_c + cys__L_c --> glu__L_c + mercppyr_c 0 1000 KPN_00955 or 16703_7_36_05038 or K_variicola_variicola_At-22_04110 or 16870_8_59_04080 or K_variicola_variicola_At-22_01688 Catalytic CYSTA R00896 rxn00647 2 Direct evidence in C. jejuni. Protein purification evidence in K. aerogenes.
CYStex L-cysteine transport via diffusion (extracellular to periplasm) cys__L_e <=> cys__L_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport CYStex - rxn08284; rxn08286; rxn10998 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYSTGL Cystathionine g lyase cyst__L_c + h2o_c --> 2obut_c + cys__L_c + nh4_c Methionine Metabolism 0 1000 KPN_03410 Catalytic CYSTGL R01001 rxn00742 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYSTL Cystathionine b-lyase cyst__L_c + h2o_c --> hcys__L_c + nh4_c + pyr_c 0 1000 KPN_01511 or KPN_03428 or KPN_03410 or KPN_04233 or Klebsiella_pneumoniae_INF310_05280 or Klebsiella_pneumoniae_KSB2_9B_05036 Catalytic CYSTL R01286 rxn15166 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYStpp L-cysteine export via facilitated transport cys__L_c --> cys__L_p "Transport, Inner Membrane" 0 1000 KPN_00233 or KPN_01622 Transport CYStpp - rxn08284; rxn08286; rxn10998 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYSTRS L-Cysteine:tRNA(Cys) ligase (AMP-forming) atp_c + cys__L_c + trnacys_c --> amp_c + cystrna_c + ppi_c 0 1000 KPN_00482 or Klebsiella_pneumoniae_KSB1_9J_01690 Catalytic CYSTRS R03650 rxn06435 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYSTS Cystathionine beta synthase hcys__L_c + ser__L_c --> cyst__L_c + h2o_c "Glycine, Serine and threonine metabolism" 0 1000 KPN_03409 Catalytic CYSTS R01289 rxn00953 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYTBDpp Cytochrome oxidase bd (ubiquinol-8: 2 protons) (periplasm) 2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_p + q8_c 0 1000 (KPN_00737 and KPN_00736) or (KPN_01930 and KPN_01931) or (KPN_01153 and KPN_01154) or (16703_5_13_02239 and 16870_8_40_00599) Catalytic CYTBDpp R11325 rxn08288 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYTBO3_4pp Cytochrome oxidase bo3 (ubiquinol-8: 4 protons) (periplasm) 4.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 4.0 h_p + q8_c Oxidative Phosphorylation 0 1000 KPN_00391 and KPN_00394 and KPN_00392 and KPN_00393 Catalytic CYTBO3_4pp - rxn30002 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYTD Cytidine deaminase cytd_c + h2o_c + h_c --> nh4_c + uri_c Nucleotide Salvage Pathway 0 1000 KPN_02584 Catalytic CYTD R01878 rxn01368 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYTDH Cytidine hydrolase cytd_c + h2o_c --> csn_c + rib__D_c Alternate Carbon Metabolism 0 1000 KPN_00025 or KPN_01912 Catalytic CYTDH R02137 rxn01541 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYTDK1 ATP:cytidine 5'-phosphotransferase atp_c + cytd_c --> adp_c + cmp_c + h_c 0 1000 KPN_02519 Catalytic CYTDK1 R00513 rxn00365 2 Evidence of udk gene in Klebsiella. Direct evidence in E. coli.
CYTDK2 Cytidine kinase (GTP) cytd_c + gtp_c --> cmp_c + gdp_c + h_c Nucleotide Salvage Pathway 0 1000 KPN_02519 Catalytic CYTDK2 R00517 rxn00369 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYTDt2pp Cytidine transport in via proton symport (periplasm) cytd_p + h_p --> cytd_c + h_c "Transport, Inner Membrane" 0 1000 KPN_03396 or KPN_02744 Transport CYTDt2pp - rxn05198; rxn08289 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYTDtex Cytidine transport via diffusion (extracellular to periplasm) cytd_e <=> cytd_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport CYTDtex - rxn08290; rxn10997; rxn13338 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYTK1 Cytidylate kinase (CMP) atp_c + cmp_c <=> adp_c + cdp_c Nucleotide Salvage Pathway -1000 1000 KPN_00937 Catalytic CYTK1 R00512 rxn00364 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
CYTK2 Cytidylate kinase (dCMP) atp_c + dcmp_c <=> adp_c + dcdp_c Nucleotide Salvage Pathway -1000 1000 KPN_00937 Catalytic CYTK2 R01665 rxn01219 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
D_LACt2pp D-lactate transport via proton symport (periplasm) h_p + lac__D_p <=> h_c + lac__D_c "Transport, Inner Membrane" -1000 1000 KPN_03947 Transport D_LACt2pp - rxn08350; rxn09772; rxn10171 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
D_LACtex D-lactate transport via diffusion (extracellular to periplasm) lac__D_e <=> lac__D_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport D_LACtex - rxn08351 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
D5KGK 2-Deoxy-5-Keto-D-gluconate kinase atp_c + d5kg_c --> adp_c + h_c + d5kgp_c 0 1000 KPN_04673 or 16870_7_82_02744 Catalytic D5KGK R04351; R05661 rxn03023 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
D5KGPA 2-Deoxy-5-keto-D-gluconate 6-phosphate aldolase d5kgp_c --> dhap_c + msa_c Inositol Metabolism 0 1000 - Catalytic D5KGPA R05378 rxn01176 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DAAD D-Amino acid dehydrogenase ala__D_c + fad_c + h2o_c --> fadh2_c + nh4_c + pyr_c 0 1000 KPN_02309 or KPN_02172 or AH0360_C4PNMANXX_GTAGAGGA-AAGGAGTA_L006_04512 Catalytic DAAD R09493 rxn08291; rxn19383 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DABAAT "L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase (DABAAT)" akg_c + h_c + 24dab_c --> aspsa_c + glu__L_c 0 1000 KPN_01802 Catalytic DABAAT R06977 rxn04786 2 Catalytic protein activity has been detected in Klebsiella and other Enterobacteriaceae.
DACTt3 Diacetyl transport out via proton antiport diact_c + h_e --> diact_e + h_c Transport 0 1000 - Transport DACTt3 - - - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DADA Deoxyadenosine deaminase dad_2_c + h_c + h2o_c --> din_c + nh4_c 0 1000 KPN_01958 or 16703_7_80_04952 Catalytic DADA R02556 rxn01858 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DADK Deoxyadenylate kinase atp_c + damp_c <=> adp_c + dadp_c Nucleotide Salvage Pathway -1000 1000 KPN_00456 Catalytic DADK R01547 rxn01127 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DADNt2pp Deoxyadenosine transport in via proton symport (periplasm) dad_2_p + h_p --> dad_2_c + h_c "Transport, Inner Membrane" 0 1000 KPN_02744 or KPN_03396 Transport DADNt2pp - rxn05317; rxn08292 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DADNtex Deoxyadenosine transport via diffusion (extracellular to periplasm) dad_2_e <=> dad_2_p "Transport, Outer Membrane" -1000 1000 KPN_00363 Transport DADNtex - rxn08293; rxn10939 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DAGK120 Diacylglycerol kinase (n-C12:0) 12dgr120_c + atp_c --> adp_c + h_c + pa120_c 0 1000 KPN_04430 or KPN_02533 Catalytic DAGK120 R02240 rxn08294 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DAGK140 Diacylglycerol kinase (n-C14:0) 12dgr140_c + atp_c --> adp_c + h_c + pa140_c 0 1000 KPN_04430 or KPN_02533 Catalytic DAGK140 R02240 rxn08295 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DAGK141 Diacylglycerol kinase (n-C14:1) 12dgr141_c + atp_c --> adp_c + h_c + pa141_c 0 1000 KPN_04430 or KPN_02533 Catalytic DAGK141 R02240 rxn08296 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DAGK160 Diacylglycerol kinase (n-C16:0) 12dgr160_c + atp_c --> adp_c + h_c + pa160_c 0 1000 KPN_04430 or KPN_02533 Catalytic DAGK160 R02240 rxn08297 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DAGK161 Diacylglycerol kinase (n-C16:1) 12dgr161_c + atp_c --> adp_c + h_c + pa161_c 0 1000 KPN_04430 or KPN_02533 Catalytic DAGK161 R02240 rxn08298 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DAGK180 Diacylglycerol kinase (n-C18:0) 12dgr180_c + atp_c --> adp_c + h_c + pa180_c 0 1000 KPN_04430 or KPN_02533 Catalytic DAGK180 R02240 rxn08299 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DAGK181 Diacylglycerol kinase (n-C18:1) 12dgr181_c + atp_c --> adp_c + h_c + pa181_c 0 1000 KPN_04430 or KPN_02533 Catalytic DAGK181 R02240 rxn08300 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DALAt2pp D-alanine transport in via proton symport (periplasm) ala__D_p + h_p --> ala__D_c + h_c "Transport, Inner Membrane" 0 1000 KPN_04601 Transport DALAt2pp - rxn05494; rxn08301 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DALAtex D-Alanine transport via diffusion (extracellular to periplasm) ala__D_e <=> ala__D_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport DALAtex - rxn08302; rxn10991 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DAMPtex DAMP transport via diffusion (extracellular to periplasm) damp_e <=> damp_p "Transport, Outer Membrane" -1000 1000 KPN_00282 or KPN_02636 or KPN_02430 or KPN_00956 or KPN_01445 Transport DAMPtex - rxn08303 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DAPAL "2,3-diaminopropionate amonnia lyase" 23dappa_c + h2o_c --> 2.0 nh4_c + pyr_c 0 1000 KPN_00963 or Klebsiella_variicola_INF022_05301 Catalytic DAPAL R00195 rxn00144 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DAPAT Cadaverine aminotranferase 15dap_c + akg_c --> glu__L_c + h2o_c + h_c + pprdn_c Lysine Metabolism 0 1000 - Catalytic DAPAT R07613 rxn12741; rxn07441 - Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.
DAPDC Diaminopimelate decarboxylase 26dap__M_c + h_c --> co2_c + lys__L_c 0 1000 KPN_03252 or Klebsiella_pneumoniae_KSB1_9A_01348 Catalytic DAPDC R00451 rxn00313 2 Inherited from previous K. pneumoniae MGH78578 model (iYL1228). See PMID: 21296962 for more information.