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Dear Author,
Thank you for the useful tool that predicts the impact of mutations using sequences. However, it currently only supports DNA data. Could you please consider adding support for mRNA mutation prediction in future updates?
mRNA sequences have exons, introns, and different strand orientations. Currently, I manually extract and mutate the SNV relevant exon, then splice it with other exons, which is inefficient and doesn't support INDELs or SVs. It would be incredibly helpful if users could input the GenCode annotations, VCF file and the tool could automatically identify the strand, locate the mutation, and output the full mutated sequence and reference sequence.
I understand that adding these features requires effort, but it would greatly benefit users. Please let me know if I can assist with testing.
Looking forward to future updates!
The text was updated successfully, but these errors were encountered:
Dear Author,
Thank you for the useful tool that predicts the impact of mutations using sequences. However, it currently only supports DNA data. Could you please consider adding support for mRNA mutation prediction in future updates?
mRNA sequences have exons, introns, and different strand orientations. Currently, I manually extract and mutate the SNV relevant exon, then splice it with other exons, which is inefficient and doesn't support INDELs or SVs. It would be incredibly helpful if users could input the GenCode annotations, VCF file and the tool could automatically identify the strand, locate the mutation, and output the full mutated sequence and reference sequence.
I understand that adding these features requires effort, but it would greatly benefit users. Please let me know if I can assist with testing.
Looking forward to future updates!
The text was updated successfully, but these errors were encountered: