diff --git a/docs/articles/index.html b/docs/articles/index.html index 9d4be6c..f792288 100644 --- a/docs/articles/index.html +++ b/docs/articles/index.html @@ -76,7 +76,7 @@

All vignettes

-

Site built with pkgdown 2.1.0.

+

Site built with pkgdown 2.1.1.

diff --git a/docs/articles/multiple_endpoints.html b/docs/articles/multiple_endpoints.html index a5d217b..56ee8c1 100644 --- a/docs/articles/multiple_endpoints.html +++ b/docs/articles/multiple_endpoints.html @@ -101,7 +101,7 @@

warfarin PKPD model
 mod_warfarin_nlmixr <- function() {
     ini({
-      #Fixed effects: population estimates 
+      #Fixed effects: population estimates
       THETA_ktr=0.106
       THETA_ka=-0.087
       THETA_cl=-2.03
@@ -110,7 +110,7 @@ 
warfarin PKPD modelTHETA_ec50=0.00724
       THETA_kout=-2.9
       THETA_e0=4.57
-      
+
       #Random effects: inter-individual variability
       ETA_ktr ~ 1.024695
       ETA_ka ~ 0.9518403
@@ -120,7 +120,7 @@ 
warfarin PKPD modelETA_ec50 ~ 0.7204165
       ETA_kout ~ 0.3563706
       ETA_e0 ~ 0.2660827
-      
+
       #Unexplained residual variability
       cp.sd <- 0.144
       cp.prop.sd <- 0.15
@@ -136,27 +136,29 @@ 
warfarin PKPD modelec50 =  exp(THETA_ec50 + ETA_ec50)
       kout = exp(THETA_kout + ETA_kout)
       e0 = exp(THETA_e0 + ETA_e0)
-      
+
       #Structural model defined using ordinary differential equations (ODE)
       DCP = center/v
       PD=1-emax*DCP/(ec50+DCP)
-      
+
       effect(0) = e0
       kin = e0*kout
-      
+
       d/dt(depot) = -ktr * depot
       d/dt(gut) =  ktr * depot -ka * gut
       d/dt(center) =  ka * gut - cl / v * center
       d/dt(effect) = kin*PD -kout*effect
-      
+
       cp = center / v
       pca = effect
-      
+
       #Model for unexplained residual variability
       cp ~ add(cp.sd) + prop(cp.prop.sd)
       pca ~ add(pca.sd)
     })
-  }
+} + +mod_warfarin_nlmixr <- mod_warfarin_nlmixr()

data: first subject from the warfarin dataset @@ -187,13 +189,12 @@

data: first subject from t poso_estim_map()

 map_warf_01  <- poso_estim_map(warf_01,mod_warfarin_nlmixr)
-#> using C compiler: ‘gcc (Ubuntu 11.4.0-1ubuntu1~22.04) 11.4.0’
 map_warf_01
 #> $eta
 #>     ETA_ktr      ETA_ka      ETA_cl       ETA_v    ETA_emax    ETA_ec50 
-#> -0.32052193 -0.54227235  0.79432182 -0.02986447  0.02383273 -0.28133882 
+#> -0.32297013 -0.54003647  0.79433822 -0.02976759  0.02346678 -0.28140889 
 #>    ETA_kout      ETA_e0 
-#> -0.30872226 -0.08386652 
+#> -0.30867037 -0.08384263 
 #> 
 #> $model
 #> ── Solved rxode2 object ──
@@ -201,11 +202,11 @@ 
data: first subject from t
 #>   THETA_ktr    THETA_ka    THETA_cl     THETA_v  THETA_emax  THETA_ec50 
 #>  0.10600000 -0.08700000 -2.03000000  2.07000000  3.40000000  0.00724000 
 #>  THETA_kout    THETA_e0       cp.sd  cp.prop.sd      pca.sd     ETA_ktr 
-#> -2.90000000  4.57000000  0.14400000  0.15000000  3.91000000 -0.32052193 
+#> -2.90000000  4.57000000  0.14400000  0.15000000  3.91000000 -0.32297013 
 #>      ETA_ka      ETA_cl       ETA_v    ETA_emax    ETA_ec50    ETA_kout 
-#> -0.54227235  0.79432182 -0.02986447  0.02383273 -0.28133882 -0.30872226 
+#> -0.54003647  0.79433822 -0.02976759  0.02346678 -0.28140889 -0.30867037 
 #>      ETA_e0 
-#> -0.08386652 
+#> -0.08384263 
 #> ── Initial Conditions ($inits): ──
 #>  depot    gut center effect 
 #>      0      0      0      0 
@@ -213,12 +214,12 @@ 
data: first subject from t
 #> # A tibble: 1,451 × 18
 #>    time   ktr    ka    cl     v  emax  ec50   kout    e0    DCP    PD   kin
 #>   <dbl> <dbl> <dbl> <dbl> <dbl> <dbl> <dbl>  <dbl> <dbl>  <dbl> <dbl> <dbl>
-#> 1   0   0.807 0.533 0.291  7.69 0.968 0.760 0.0404  88.8 0      1      3.59
-#> 2   0.1 0.807 0.533 0.291  7.69 0.968 0.760 0.0404  88.8 0.0267 0.967  3.59
-#> 3   0.2 0.807 0.533 0.291  7.69 0.968 0.760 0.0404  88.8 0.102  0.885  3.59
-#> 4   0.3 0.807 0.533 0.291  7.69 0.968 0.760 0.0404  88.8 0.219  0.783  3.59
-#> 5   0.4 0.807 0.533 0.291  7.69 0.968 0.760 0.0404  88.8 0.373  0.681  3.59
-#> 6   0.5 0.807 0.533 0.291  7.69 0.968 0.760 0.0404  88.8 0.557  0.590  3.59
+#> 1   0   0.805 0.534 0.291  7.69 0.968 0.760 0.0404  88.8 0      1      3.59
+#> 2   0.1 0.805 0.534 0.291  7.69 0.968 0.760 0.0404  88.8 0.0267 0.967  3.59
+#> 3   0.2 0.805 0.534 0.291  7.69 0.968 0.760 0.0404  88.8 0.102  0.885  3.59
+#> 4   0.3 0.805 0.534 0.291  7.69 0.968 0.760 0.0404  88.8 0.219  0.783  3.59
+#> 5   0.4 0.805 0.534 0.291  7.69 0.968 0.760 0.0404  88.8 0.373  0.681  3.59
+#> 6   0.5 0.805 0.534 0.291  7.69 0.968 0.760 0.0404  88.8 0.557  0.590  3.59
 #> # ℹ 1,445 more rows
 #> # ℹ 6 more variables: cp <dbl>, pca <dbl>, depot <dbl>, gut <dbl>,
 #> #   center <dbl>, effect <dbl>
@@ -258,7 +259,7 @@ 
data: first subject from t
-

Site built with pkgdown 2.1.0.

+

Site built with pkgdown 2.1.1.

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