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--call outputs a path that doesn't exist in the graph #35

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wwliao opened this issue Feb 10, 2021 · 3 comments
Open

--call outputs a path that doesn't exist in the graph #35

wwliao opened this issue Feb 10, 2021 · 3 comments
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@wwliao
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wwliao commented Feb 10, 2021

Hi Heng,

I notice a path >s48420>s48421>s48428 in the --call outputs that doesn't actually exist in the GRCh38-freeze1.gfa because there is no such link between s48421 and s48428.
Here are the calls containing this path:

chr7	144186940	144296182	>s48420	>s48428	>s48421:10670:-:HG00438#2#h2tg000019l:15485853:15496541
chr7	144186940	144296182	>s48420	>s48428	>s48421:10670:-:HG01123#1#h1tg000013l:13689309:13699991
chr7	144186940	144296182	>s48420	>s48428	>s48421:10670:+:HG01243#2#h2tg000196l:341837:352526
chr7	144186940	144296182	>s48420	>s48428	>s48421:10670:+:HG02080#2#h2tg000103l:15430162:15440860
chr7	144186940	144296182	>s48420	>s48428	>s48421:10670:+:HG03492#2#h2tg000104l:354601:365286

The GRCh38-freeze1.gfa and its calls are both from ftp://ftp.dfci.harvard.edu/pub/hli/minigraph/HPP/

I'm not sure how to interpret this result.

Thanks,
Wen-Wei

@lh3
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lh3 commented Feb 10, 2021

This is probably a bug. You can take it as uncalled . for now.

@lh3 lh3 added the bug Something isn't working label Feb 10, 2021
@lh3
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lh3 commented Mar 11, 2021

I can confirm it is a bug caused by inversions. It is difficult to fix it. For now, take such inconsistencies as uncalled. Cases like this should be fairly rare.

@wwliao
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wwliao commented Mar 11, 2021

Thank you for looking into this!

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