diff --git a/.idea/encodings.xml b/.idea/encodings.xml
new file mode 100644
index 0000000..15a15b2
--- /dev/null
+++ b/.idea/encodings.xml
@@ -0,0 +1,4 @@
+
+
+
+
\ No newline at end of file
diff --git a/.idea/markdown-navigator.xml b/.idea/markdown-navigator.xml
new file mode 100644
index 0000000..808794e
--- /dev/null
+++ b/.idea/markdown-navigator.xml
@@ -0,0 +1,83 @@
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
\ No newline at end of file
diff --git a/.idea/markdown-navigator/profiles_settings.xml b/.idea/markdown-navigator/profiles_settings.xml
new file mode 100644
index 0000000..57927c5
--- /dev/null
+++ b/.idea/markdown-navigator/profiles_settings.xml
@@ -0,0 +1,3 @@
+
+
+
\ No newline at end of file
diff --git a/.idea/misc.xml b/.idea/misc.xml
new file mode 100644
index 0000000..28a804d
--- /dev/null
+++ b/.idea/misc.xml
@@ -0,0 +1,6 @@
+
+
+
+
+
+
\ No newline at end of file
diff --git a/.idea/modules.xml b/.idea/modules.xml
new file mode 100644
index 0000000..8148c50
--- /dev/null
+++ b/.idea/modules.xml
@@ -0,0 +1,8 @@
+
+
+
+
+
+
+
+
\ No newline at end of file
diff --git a/.idea/multiexseq.iml b/.idea/multiexseq.iml
new file mode 100644
index 0000000..d6ebd48
--- /dev/null
+++ b/.idea/multiexseq.iml
@@ -0,0 +1,9 @@
+
+
+
+
+
+
+
+
+
\ No newline at end of file
diff --git a/.idea/vcs.xml b/.idea/vcs.xml
new file mode 100644
index 0000000..35eb1dd
--- /dev/null
+++ b/.idea/vcs.xml
@@ -0,0 +1,6 @@
+
+
+
+
+
+
\ No newline at end of file
diff --git a/Developement.md b/Developement.md
deleted file mode 100644
index c4d7faa..0000000
--- a/Developement.md
+++ /dev/null
@@ -1,11 +0,0 @@
-# Team members for software development
-
-
-# Details for members
-
-| Name | Email | Site | institute |
-|---------------|:------------------------: |-----------------------------: |---------------|
-| Qi Zhao | zhaoqi@sysucc.org.cn | https://github.com/likelet | SYSUCC |
-
-
-# to be filled in
diff --git a/Development.md b/Development.md
new file mode 100644
index 0000000..4791bb4
--- /dev/null
+++ b/Development.md
@@ -0,0 +1,15 @@
+# Team members for software development
+
+
+# Details for members
+
+| Name | Email | Site | institute |
+|---------------|:------------------------: |-----------------------------: |---------------|
+| Qi Zhao | zhaoqi@sysucc.org.cn | https://github.com/likelet | SYSUCC |
+| Chengwei Wang | wangchw8@mail2.sysu.edu.cn| https://github.com/Ninomoriaty| SYSU |
+| Ziwei Wang | wangzw.edu@gmail.com | https://github.com/ZIWEI-WONG | SYSU |
+| Chen Jianyu | 364500513@qq.com | https://github.com/chenjy327 | SYSU |
+| Zheng Li | 419125762@qq.com | https://github.com/lizheng141026 | SYSU |
+| Xin Wang | wangx555@mail2.sysu.edu.cn| https://github.com/Wangxin555 | SYSU |
+| Liu Jie | 1953640796@qq.com | https://github.com/LiuJie1117 | SYSU
+# to be filled in
diff --git a/Dockerfile b/Dockerfile
index 31bb6b8..cde0b33 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -2,6 +2,22 @@ FROM nfcore/base
LABEL authors="Qi Zhao" \
description="Docker image containing all requirements for nf-core/multiexseq pipeline"
-COPY environment.yml /
-RUN conda env create -f /environment.yml && conda clean -a
-ENV PATH /opt/conda/envs/nf-core-multiexseq-1.0dev/bin:$PATH
+COPY environment1.yml environment2.yml ./
+
+RUN wget http://www.openbioinformatics.org/annovar/download/0wgxR2rIVP/annovar.latest.tar.gz && tar -xzvf annovar.latest.tar.gz && rm annovar.latest.tar.gz
+
+ENV PATH /opt/conda/envs/multiexseq_facets/bin:$PATH
+RUN conda env create -f /environment1.yml -n multiexseq_facets && conda clean -a
+
+ENV PATH /opt/conda/envs/multiexseq_freec/bin:$PATH
+RUN conda env create -f /environment2.yml -n multiexseq_freec && conda clean -a
+
+RUN cd annovar \
+ #&& echo "./opt/conda/etc/profile.d/conda.sh" >> ~/.bashrc \
+ #&& echo "conda activate" >> ~/.bashrc \
+ #&& conda activate multiexseq_freec \
+ && perl annotate_variation.pl -downdb -buildver hg19 -webfrom annovar refGene humandb/
+
+# ENV PATH /opt/conda/envs/nf-core-multiexseq-1.0dev/bin:$PATH
+
+CMD ["/bin/bash"]
\ No newline at end of file
diff --git a/DockerfileOrigin b/DockerfileOrigin
new file mode 100644
index 0000000..278f1bf
--- /dev/null
+++ b/DockerfileOrigin
@@ -0,0 +1,28 @@
+## images base Ubuntu 16.04
+FROM biocontainers/biocontainers:latest
+
+## metadata
+LABEL base.image="biocontainers:latest"
+LABEL version="2"
+LABEL about.tags="test1"
+
+## Enviroment variables
+
+## runtimes 3
+#ENV PATH /opt/conda/envs/multiexseq_origin/bin:$PATH
+#RUN conda create -c aroth85 --name multiexseq_origin samtools pyclone
+
+RUN conda config --add channels bioconda &&\
+ conda config --add channels aroth85
+
+ENV PATH /opt/conda/envs/multiexseq_facets/bin:$PATH
+RUN conda create --name multiexseq_facets samtools pyclone r-facets
+
+ENV PATH /opt/conda/envs/multiexseq_freec/bin:$PATH
+RUN conda create --name multiexseq_freec samtools pyclone control-freec
+
+# annovar* (it seems that annovar could always be used as .pl documents so I just copy it..)
+# RUN conda install perl
+# ADD annovar.latest.tar.gz .
+
+CMD ["/bin/bash"]
diff --git a/README.md b/README.md
index c4676b6..326261c 100644
--- a/README.md
+++ b/README.md
@@ -1,4 +1,4 @@
-# multiexseq
+# MesKit
**Analysis pipelie for multi WEX analysis**
> this readme was generated by nf-core tools
diff --git a/conf/LiuJie.config b/conf/LiuJie.config
new file mode 100644
index 0000000..5ab2f8a
--- /dev/null
+++ b/conf/LiuJie.config
@@ -0,0 +1 @@
+Hello
\ No newline at end of file
diff --git a/conf/chenjy.config b/conf/chenjy.config
new file mode 100644
index 0000000..e69de29
diff --git a/conf/wangChengWei.conf b/conf/wangChengWei.conf
new file mode 100644
index 0000000..8b13789
--- /dev/null
+++ b/conf/wangChengWei.conf
@@ -0,0 +1 @@
+
diff --git a/conf/ziweiwang.config b/conf/ziweiwang.config
new file mode 100644
index 0000000..e69de29
diff --git a/environment.yml b/environment1.yml
similarity index 79%
rename from environment.yml
rename to environment1.yml
index 9836367..1c3f2fa 100644
--- a/environment.yml
+++ b/environment1.yml
@@ -3,7 +3,11 @@ channels:
- conda-forge
- bioconda
- defaults
+ - aroth85
dependencies:
# TODO nf-core: Add required software dependencies here
- fastqc=0.11.8
- multiqc=1.6
+ - samtools
+ - pyclone
+ - r-facets
diff --git a/environment2.yml b/environment2.yml
new file mode 100644
index 0000000..d9f0b78
--- /dev/null
+++ b/environment2.yml
@@ -0,0 +1,13 @@
+name: nf-core-multiexseq-1.0dev
+channels:
+ - conda-forge
+ - bioconda
+ - defaults
+ - aroth85
+dependencies:
+ # TODO nf-core: Add required software dependencies here
+ - fastqc=0.11.8
+ - multiqc=1.6
+ - samtools
+ - pyclone
+ - control-freec
\ No newline at end of file