diff --git a/resources/curated/bl_genes.tsv b/resources/curated/bl_genes.tsv index 053b363e..42509b62 100644 --- a/resources/curated/bl_genes.tsv +++ b/resources/curated/bl_genes.tsv @@ -1,181 +1,129 @@ -Gene earliest_support_BL Curated_BL_driver aSHM_target_DLBCL Curator_comments Enrichment_DLBCL_BL frequency_BL_Thomas frequency_BL_Panea n_BL_Panea_original -ACE 23143597 FALSE FALSE -ACAD9 23143597 FALSE FALSE -ATP2C2 23143597 FALSE FALSE -ALPK2 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 5.1 9.9 5 -ARID1A 23143597 TRUE FALSE Mutated at high frequency in both DLBCL and BL BL 36 19.8 24 -B2M NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 2.5 3 NA -BACH2 31558468 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. BL 0.4 5 3 -BCL10 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.4 NA NA -BCL11A NA FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. DLBCL 1.7 5.9 NA -BRAF 23143597 FALSE FALSE -BCL2 23143597 FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 0 1 NA -BCL2L11 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 2.1 1 NA -BCL6 23143597 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. DLBCL 3.4 7.9 18 -BCL7A 30617194 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. DLBCL 5.5 5 6 -BCR 31558468 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. NA 6.4 10.9 7 -BIRC6 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 3.8 14.9 NA -BRD4 23143597 FALSE FALSE -BMP7 31558468 TRUE FALSE Confirmed by multiple studies NA 8.9 5 9 -BTG2 23143597 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. NA 4.2 9.9 16 -CARD4 23143597 FALSE FALSE -CAD 23143597 FALSE FALSE -C10orf12 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0 NA NA -C6orf27 23143597 FALSE FALSE -CARD11 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.7 10.9 NA -CCND3 22885699 TRUE FALSE Mutated at high frequency in both DLBCL and BL BL 28 17.8 19 -CCNF 26468873 FALSE FALSE Hot spot reported in this study is a rare germline variant in African populations NA NA NA NA -CCT6B 23143597 FALSE FALSE -CD58 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.8 2 NA -CD70 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.4 3 5 -CD79B NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0 4 6 -CD83 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.7 NA NA -CDC73 23143597 FALSE FALSE -CDH17 23143597 FALSE FALSE -CDKN2A NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 3 3 NA -CDKN2C 36201743 FALSE FALSE Low frequency in initial study. Awaiting confirmation from additional cohorts BL 3.4 3 NA -CHD8 36201743 TRUE FALSE Confirmed by multiple studies BL 8.5 16.8 10 -COL4A2 23143597 FALSE FALSE -CYB5D1 23143597 FALSE FALSE -CREBBP 23143597 FALSE FALSE DLBCL gene with extremely low mutation rate in BL in most studies. Nominating study is an outlier. DLBCL 3 12.9 11 -CTCF 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.7 6.9 7 -CXCR4 31558468 FALSE TRUE Mutation frequencies are inconsistent between studies. Nominating study is an outlier. NA 2.1 2 9 -CYP4F22 23143597 FALSE FALSE -DDX3X 22885699 TRUE FALSE Mutated at high frequency in both DLBCL and BL BL 48.7 39.6 48 -DLGAP1 23143597 FALSE FALSE -DNMT1 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.7 5 15 -DTX1 23143597 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. NA 5.9 8.9 16 -EBF1 NA FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. DLBCL 1.3 5.9 NA -EHD1 23143597 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. DLBCL 0 5.9 NA -EML2 23143597 FALSE FALSE -EIF4A1 31558468 TRUE FALSE Confirmed by multiple studies NA 5.1 6.9 12 -EP300 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 4.2 7.9 NA -EPHB2 23143597 FALSE FALSE -EPPK1 31558468 TRUE FALSE Mutation pattern and MutSig results etc require further scrutiny. NA 7.6 15.8 5 -ETS1 31558468 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. NA 7.6 11.9 2 -EIF2C4 23143597 FALSE FALSE -EZH2 23143597 FALSE FALSE DLBCL gene with extremely low mutation rate in BL in most studies. Nominating study is an outlier. DLBCL 1.3 10.9 NA -ENTPD3 23143597 FALSE FALSE -FAS NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.7 4 NA -FAM129B 23143597 FALSE FALSE -FBXO11 36201743 TRUE FALSE Confirmed by multiple studies BL 21.6 15.8 12 -FIP1L1 NA FALSE FALSE Low frequency in initial study. Awaiting confirmation from additional cohorts BL 2.5 2 NA -FOXO1 22885699 TRUE FALSE Mutated at high frequency in both DLBCL and BL DLBCL 28 21.8 22 -FTCD 23143597 FALSE FALSE -FZD3 31558468 FALSE FALSE Mutation frequencies are inconsistent between studies. Nominating study is an outlier. NA 0 1 NA -FGFR3 23143597 FALSE FALSE -GGTLA4 23143597 FALSE FALSE -GNA13 23143597 TRUE FALSE Mutated at high frequency in both DLBCL and BL BL 21.6 20.8 27 -GNAI2 30617194 TRUE FALSE Mutated at high frequency in both DLBCL and BL BL 9.7 8.9 20 -GRB2 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study DLBCL 0.4 1 NA -GRIK5 23143597 FALSE FALSE -HIST1H1B NA FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. DLBCL 5.5 4 NA -HIST1H1C 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 3.8 9.9 19 -HIST1H1D NA FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. DLBCL 4.7 4 NA -HIST1H1E 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 7.6 19.8 42 -HIST1H2AG 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 2.5 1 3 -HIST1H2AM 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.7 3 NA -HIST1H2BK 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 4.7 7.9 38 -HIST1H3D 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.7 3 2 -HIST1H3H 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.3 5.9 26 -HIST1H3I 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0 2 NA -HIST1H3J 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.7 5 13 -HIST1H4J 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0.4 NA NA -HLA-A NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.3 NA NA -HLA-B NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 3.8 5 NA -HLA-DMB NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0 NA NA -HNRNPU 31558468 TRUE FALSE Confirmed by multiple studies BL 6.4 8.9 18 -HVCN1 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.8 2 NA -ID3 23143595 TRUE FALSE Confirmed by multiple studies BL 47 31.7 33 -ICK 23143597 FALSE FALSE -ITPR3 23143597 FALSE FALSE -IGLL5 NA FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. DLBCL 25 23.8 27 -IKZF3 31558468 FALSE FALSE Mutation frequencies are inconsistent between studies. Nominating study is an outlier. NA 0.8 3 5 -IRF8 NA FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 1.3 6.9 7 -KCNK10 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0.8 1 NA -KIFC3 23143597 FALSE FALSE -KLHL6 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 3 6.9 NA -KMT2D 30617194 TRUE FALSE Mutated at high frequency in both DLBCL and BL DLBCL 14 15.8 13 -LTB NA FALSE TRUE Borderline evidence to consider this also a BL gene DLBCL 3 5.9 NA -MAP3K6 23143597 FALSE FALSE -MCL1 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 2.1 2 4 -MEF2B NA FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 0.8 3 NA -MME 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0.8 5.9 2 -MTOR 31558468 FALSE FALSE Mutation frequencies are inconsistent between studies. Nominating study is an outlier. NA 3.4 10.9 5 -MYC TBD TRUE TRUE Hot spots from aSHM can affect MYC protein stability BL 60.2 49.5 64 -MYH10 23143597 FALSE FALSE -MYD88 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.4 1 NA -MYO1E NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.3 4 NA -NBEAL1 23143597 FALSE FALSE -NFKBIA NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.7 2 NA -NOTCH1 23143597 FALSE FALSE -NOTCH2 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0 5 NA -NRXN2 23143597 FALSE FALSE -OSBPL10 NA FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. DLBCL 2.1 3 NA -P2RY8 25274307 TRUE FALSE Mutated at high frequency in both DLBCL and BL BL 11 NA NA -PABPC4L 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.3 3 1 -PC 23143597 FALSE FALSE -PCBP1 23143597 TRUE FALSE Confirmed by multiple studies BL 12.3 11.9 5 -PCDHA11 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.3 3 4 -PDZRN3 31558468 FALSE FALSE Mutation frequencies are inconsistent between studies. Nominating study is an outlier. NA 2.1 9.9 4 -PHF6 36201743 TRUE FALSE Recently identified. Ideally this should be confirmed in more cohorts. BL 5.5 5.9 NA -P2RY2 23143597 FALSE FALSE -POLRMT 23143597 FALSE FALSE -PIK3R1 23143597 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 2.5 4 1 -PLCG2 31558468 FALSE FALSE Mutation frequencies are inconsistent between studies. Nominating study is an outlier. NA 0.8 10.9 3 -PMAIP1 NA FALSE FALSE Low frequency in initial study. Awaiting confirmation from additional cohorts BL 3 5 NA -POR 23143597 FALSE FALSE -PRDM1 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.8 5.9 NA -PRSS22 23143597 FALSE FALSE -PRKCD NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.3 5.9 NA -PTEN 23143597 TRUE FALSE Confirmed by multiple studies BL 4.7 4 6 -PTPRN 23143597 FALSE FALSE -PXDNL 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 3 9.9 2 -RANBP6 23143597 FALSE FALSE -RAC2 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. DLBCL 0.4 NA NA -RBP3 23143597 FALSE FALSE -RET 23143597 FALSE FALSE -RFX7 TBD TRUE FALSE Confirmed by multiple studies BL 9.3 4 4 -RHOA TBD TRUE FALSE Confirmed by multiple studies BL 8.1 12.9 9 -RNF144B 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0.4 NA NA -RPL22 NA FALSE FALSE Low frequency in initial study. Awaiting confirmation from additional cohorts BL 3 2 NA -SALL3 23143597 FALSE FALSE -SAPS2 23143597 FALSE FALSE -SBF1 23143597 FALSE FALSE -S1PR2 25274307 FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 0 4 1 -SEPT10 NA FALSE FALSE Low frequency in initial study. Awaiting confirmation from additional cohorts BL 2.1 2 NA -SGK1 NA FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 2.5 4 NA -SIN3A 30617194 TRUE FALSE Confirmed by multiple studies BL 10.6 14.9 12 -SMARCA4 23143597 TRUE FALSE Confirmed by multiple studies BL 17.8 18.8 20 -SNTB2 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0 2 NA -SLC29A2 23143597 FALSE FALSE -SOCS1 NA FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 1.7 3 NA -SP3 31558468 FALSE FALSE Low frequency in initial study. Awaiting confirmation from additional cohorts BL 2.5 5 NA -SF3B1 23143597 FALSE FALSE -SHANK1 23143597 FALSE FALSE -STAT3 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0 1 NA -STAT6 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.7 2 NA -SYNCRIP 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study BL 2.5 5 NA -SYNGAP1 23143597 FALSE FALSE -TBL1XR1 NA FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 4.7 7.9 NA -TBC1D9B 23143597 FALSE FALSE -TCF3 22885699 TRUE FALSE Confirmed by multiple studies BL 11 9.9 5 -TCL1A 30617194 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. BL 5.9 4 5 -TET2 31558468 FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 5.1 10.9 NA -TIGD6 23143597 FALSE FALSE -TPST2 23143597 FALSE FALSE -TFAP4 30617194 TRUE FALSE Confirmed by multiple studies BL 10.6 9.9 12 -TMEM30A NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.3 5 NA -TMSB4X NA FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 0 2 1 -TNFAIP3 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.8 2 NA -TNFRSF14 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.8 3 NA -TOX NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.8 5.9 NA -TP53 NA TRUE FALSE Confirmed by multiple studies BL 41.9 43.6 5 -UBE2A NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0 3 NA -USP7 TBD TRUE FALSE Confirmed by multiple studies BL 6.8 5.9 6 -WDR7 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0.4 6.9 2 -WNK1 36201743 TRUE FALSE Confirmed by multiple studies BL 6.8 11.9 NA -WNK2 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0.8 10.9 4 -ZFP36L1 NA FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 2.1 3 3 -ARHGEF1 25274307 FALSE FALSE Not recurrently mutated in other studies since initial report NA 2 NA NA -ZNF229 23143597 FALSE FALSE +Gene earliest_support_BL Curated_BL_driver aSHM_target_DLBCL Curator_comments Enrichment_DLBCL_BL frequency_BL_Thomas frequency_BL_Panea n_BL_Panea_original frequency_BL_Panea_original CIViC +ALPK2 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 5.1 9.9 5 5 FALSE +ARID1A 23143597 TRUE FALSE Mutated at high frequency in both DLBCL and BL BL 36 19.8 24 23.8 TRUE +B2M NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 2.5 3 NA NA FALSE +BACH2 31558468 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. BL 0.4 5 3 3 FALSE +BCL10 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.4 NA NA NA FALSE +BCL11A NA FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. DLBCL 1.7 5.9 NA NA FALSE +BCL2 NA FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 0 1 NA NA FALSE +BCL2L11 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 2.1 1 NA NA FALSE +BCL6 30617194 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. DLBCL 3.4 7.9 18 17.8 FALSE +BCL7A 30617194 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. DLBCL 5.5 5 6 5.9 TRUE +BCR 31558468 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. NA 6.4 10.9 7 6.9 FALSE +BIRC6 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 3.8 14.9 NA NA FALSE +BMP7 31558468 TRUE FALSE Confirmed by multiple studies NA 8.9 5 9 8.9 TRUE +BTG2 31558468 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. NA 4.2 9.9 16 15.8 FALSE +C10orf12 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0 NA NA NA FALSE +CARD11 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.7 10.9 NA NA FALSE +CCND3 22885699 TRUE FALSE Mutated at high frequency in both DLBCL and BL BL 28 17.8 19 18.8 TRUE +CCNF 26468873 FALSE FALSE Hot spot reported in this study is a rare germline variant in African populations NA NA NA NA NA FALSE +CD58 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.8 2 NA NA FALSE +CD70 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.4 3 5 5 FALSE +CD79B NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0 4 6 5.9 FALSE +CD83 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.7 NA NA NA FALSE +CDKN2A NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 3 3 NA NA TRUE +CDKN2C 36201743 FALSE FALSE Low frequency in initial study. Awaiting confirmation from additional cohorts BL 3.4 3 NA NA FALSE +CHD8 36201743 TRUE FALSE Confirmed by multiple studies BL 8.5 16.8 10 9.9 TRUE +CREBBP 23143597 FALSE FALSE DLBCL gene with extremely low mutation rate in BL in most studies. Nominating study is an outlier. DLBCL 3 12.9 11 10.9 FALSE +CTCF 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.7 6.9 7 6.9 FALSE +CXCR4 31558468 FALSE TRUE Mutation frequencies are inconsistent between studies. Nominating study is an outlier. NA 2.1 2 9 8.9 FALSE +DDX3X 22885699 TRUE FALSE Mutated at high frequency in both DLBCL and BL BL 48.7 39.6 48 47.5 TRUE +DNMT1 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.7 5 15 14.9 FALSE +DTX1 31558468 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. NA 5.9 8.9 16 15.8 FALSE +EBF1 NA FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. DLBCL 1.3 5.9 NA NA FALSE +EHD1 NA FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. DLBCL 0 5.9 NA NA FALSE +EIF4A1 31558468 TRUE FALSE Confirmed by multiple studies NA 5.1 6.9 12 11.9 TRUE +EP300 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 4.2 7.9 NA NA FALSE +EPPK1 31558468 TRUE FALSE Mutation pattern and MutSig results etc require further scrutiny. NA 7.6 15.8 5 5 FALSE +ETS1 31558468 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. NA 7.6 11.9 2 2 FALSE +EZH2 23143597 FALSE FALSE DLBCL gene with extremely low mutation rate in BL in most studies. Nominating study is an outlier. DLBCL 1.3 10.9 NA NA FALSE +FAS NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.7 4 NA NA FALSE +FBXO11 36201743 TRUE FALSE Confirmed by multiple studies BL 21.6 15.8 12 11.9 TRUE +FIP1L1 NA FALSE FALSE Low frequency in initial study. Awaiting confirmation from additional cohorts BL 2.5 2 NA NA FALSE +FOXO1 22885699 TRUE FALSE Mutated at high frequency in both DLBCL and BL DLBCL 28 21.8 22 21.8 TRUE +FZD3 31558468 FALSE FALSE Mutation frequencies are inconsistent between studies. Nominating study is an outlier. NA 0 1 NA NA FALSE +GNA13 23143597 TRUE FALSE Mutated at high frequency in both DLBCL and BL BL 21.6 20.8 27 26.7 TRUE +GNAI2 30617194 TRUE FALSE Mutated at high frequency in both DLBCL and BL BL 9.7 8.9 20 19.8 TRUE +GRB2 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study DLBCL 0.4 1 NA NA FALSE +HIST1H1B NA FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. DLBCL 5.5 4 NA NA FALSE +HIST1H1C 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 3.8 9.9 19 18.8 FALSE +HIST1H1D NA FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. DLBCL 4.7 4 NA NA FALSE +HIST1H1E 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 7.6 19.8 42 41.6 FALSE +HIST1H2AG 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 2.5 1 3 3 FALSE +HIST1H2AM 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.7 3 NA NA FALSE +HIST1H2BK 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 4.7 7.9 38 37.6 FALSE +HIST1H3D 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.7 3 2 2 FALSE +HIST1H3H 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.3 5.9 26 25.7 FALSE +HIST1H3I 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0 2 NA NA FALSE +HIST1H3J 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.7 5 13 12.9 FALSE +HIST1H4J 31558468 FALSE TRUE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0.4 NA NA NA FALSE +HLA-A NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.3 NA NA NA FALSE +HLA-B NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 3.8 5 NA NA FALSE +HLA-DMB NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0 NA NA NA FALSE +HNRNPU 31558468 TRUE FALSE Confirmed by multiple studies BL 6.4 8.9 18 17.8 TRUE +HVCN1 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.8 2 NA NA FALSE +ID3 23143595 TRUE FALSE Confirmed by multiple studies BL 47 31.7 33 32.7 TRUE +IGLL5 NA FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. DLBCL 25 23.8 27 26.7 FALSE +IKZF3 31558468 FALSE FALSE Mutation frequencies are inconsistent between studies. Nominating study is an outlier. NA 0.8 3 5 5 FALSE +IRF8 NA FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 1.3 6.9 7 6.9 FALSE +KCNK10 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0.8 1 NA NA FALSE +KLHL6 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 3 6.9 NA NA FALSE +KMT2D 30617194 TRUE FALSE Mutated at high frequency in both DLBCL and BL DLBCL 14 15.8 13 12.9 TRUE +LTB NA FALSE TRUE Borderline evidence to consider this also a BL gene DLBCL 3 5.9 NA NA FALSE +MCL1 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 2.1 2 4 4 FALSE +MEF2B NA FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 0.8 3 NA NA FALSE +MME 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0.8 5.9 2 2 FALSE +MTOR 31558468 FALSE FALSE Mutation frequencies are inconsistent between studies. Nominating study is an outlier. NA 3.4 10.9 5 5 FALSE +MYC TBD TRUE TRUE Hot spots from aSHM can affect MYC protein stability BL 60.2 49.5 64 63.4 FALSE +MYD88 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.4 1 NA NA FALSE +MYO1E NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.3 4 NA NA FALSE +NFKBIA NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.7 2 NA NA FALSE +NOTCH2 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0 5 NA NA FALSE +OSBPL10 NA FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. DLBCL 2.1 3 NA NA FALSE +P2RY8 25274307 TRUE FALSE Mutated at high frequency in both DLBCL and BL BL 11 NA NA NA TRUE +PABPC4L 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.3 3 1 1 FALSE +PCBP1 26173642 TRUE FALSE Confirmed by multiple studies BL 12.3 11.9 5 5 TRUE +PCDHA11 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 1.3 3 4 4 FALSE +PDZRN3 31558468 FALSE FALSE Mutation frequencies are inconsistent between studies. Nominating study is an outlier. NA 2.1 9.9 4 4 FALSE +PHF6 36201743 TRUE FALSE Recently identified. Ideally this should be confirmed in more cohorts. BL 5.5 5.9 NA NA FALSE +PIK3R1 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 2.5 4 1 1 FALSE +PLCG2 31558468 FALSE FALSE Mutation frequencies are inconsistent between studies. Nominating study is an outlier. NA 0.8 10.9 3 3 FALSE +PMAIP1 NA FALSE FALSE Low frequency in initial study. Awaiting confirmation from additional cohorts BL 3 5 NA NA FALSE +PRDM1 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.8 5.9 NA NA FALSE +PRKCD NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.3 5.9 NA NA FALSE +PTEN TBD TRUE FALSE Confirmed by multiple studies BL 4.7 4 6 5.9 TRUE +PXDNL 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 3 9.9 2 2 FALSE +RAC2 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. DLBCL 0.4 NA NA NA FALSE +RFX7 TBD TRUE FALSE Confirmed by multiple studies BL 9.3 4 4 4 TRUE +RHOA TBD TRUE FALSE Confirmed by multiple studies BL 8.1 12.9 9 8.9 TRUE +RNF144B 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0.4 NA NA NA FALSE +RPL22 NA FALSE FALSE Low frequency in initial study. Awaiting confirmation from additional cohorts BL 3 2 NA NA FALSE +S1PR2 25274307 FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 0 4 1 1 FALSE +SEPT10 NA FALSE FALSE Low frequency in initial study. Awaiting confirmation from additional cohorts BL 2.1 2 NA NA FALSE +SGK1 NA FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 2.5 4 NA NA FALSE +SIN3A 30617194 TRUE FALSE Confirmed by multiple studies BL 10.6 14.9 12 11.9 TRUE +SMARCA4 23143597 TRUE FALSE Confirmed by multiple studies BL 17.8 18.8 20 19.8 TRUE +SNTB2 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0 2 NA NA FALSE +SOCS1 NA FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 1.7 3 NA NA FALSE +SP3 31558468 FALSE FALSE Low frequency in initial study. Awaiting confirmation from additional cohorts BL 2.5 5 NA NA FALSE +STAT3 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0 1 NA NA FALSE +STAT6 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.7 2 NA NA FALSE +SYNCRIP 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study BL 2.5 5 NA NA FALSE +TBL1XR1 NA FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 4.7 7.9 NA NA FALSE +TCF3 22885699 TRUE FALSE Confirmed by multiple studies BL 11 9.9 5 5 TRUE +TCL1A 30617194 FALSE TRUE aSHM target genes have elevated mutation rate but the mutations may not represent drivers. More evidence is needed. BL 5.9 4 5 5 FALSE +TET2 31558468 FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 5.1 10.9 NA NA FALSE +TFAP4 30617194 TRUE FALSE Confirmed by multiple studies BL 10.6 9.9 12 11.9 TRUE +TMEM30A NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 1.3 5 NA NA FALSE +TMSB4X NA FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 0 2 1 1 FALSE +TNFAIP3 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.8 2 NA NA FALSE +TNFRSF14 NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.8 3 NA NA FALSE +TOX NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0.8 5.9 NA NA FALSE +TP53 NA TRUE FALSE Confirmed by multiple studies BL 41.9 43.6 5 5 TRUE +UBE2A NA FALSE FALSE DLBCL gene with extremely low mutation rate in BL DLBCL 0 3 NA NA FALSE +USP7 TBD TRUE FALSE Confirmed by multiple studies BL 6.8 5.9 6 5.9 TRUE +WDR7 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0.4 6.9 2 2 FALSE +WNK1 36201743 TRUE FALSE Confirmed by multiple studies BL 6.8 11.9 NA NA TRUE +WNK2 31558468 FALSE FALSE Low frequency of coding mutations in all cohorts including initial study after reanalysis of raw data. Mutations in this gene reported by Panea et al were not well supported by the data in that study. NA 0.8 10.9 4 4 FALSE +ZFP36L1 NA FALSE TRUE DLBCL gene with extremely low mutation rate in BL DLBCL 2.1 3 3 3 FALSE +ARHGEF1 25274307 FALSE FALSE Not recurrently mutated in other studies since initial report NA 2 NA NA NA FALSE