---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---

[[_TOC_]]

## Overview

ARID1A (AT-rich interactive domain-containing protein 1A) is a gene that encodes a subunit of the SWI/SNF chromatin remodeling complex, which is involved in regulating DNA accessibility. Mutations in ARID1A are implicated in various cancers, including B-cell lymphomas. They are the most abundant in Burkitt lymphoma but also occur in FL and, to a lesser extent, DLBCL. 
Overall, components of SWI/SNF have been identified as an emerging theme in germinal centre-derived B-cell lymphomas but their role has not been thoroughly elucidated.[@lunningMutationChromatinModifiers2015]


## Relevance tier by entity
|Entity|Tier|Description               |
|:------:|:----:|--------------------------|
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene[@wienandGenomicAnalysesFlowsorted2019]|
|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene[@rossiCodingGenomeSplenic2012]|
|![BL](images/icons/BL_tier1.png)    |1   |high-confidence BL gene   [@loveGeneticLandscapeMutations2012]|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene[@zhangGeneticHeterogeneityDiffuse2013; @reddyGeneticFunctionalDrivers2017; @hubschmannMutationalMechanismsShaping2021]|
|![FL](images/icons/FL_tier1.png)    |1   |high-confidence FL gene   [@krysiakRecurrentSomaticMutations2017]|

## Mutation incidence in large cohorts

[[include:DLBCL_ARID1A.md]]
[[include:FL_ARID1A.md]]
[[include:BL_ARID1A.md]]


## Mutation pattern and selective pressure estimates

[[include:dnds_ARID1A.md]]

[[include:browser_ARID1A.md]]

## Expression
![](images/gene_expression/ARID1A_by_pathology.svg)
<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->
<!-- MZL: rossiCodingGenomeSplenic2012c -->
<!-- DLBCL: zhangGeneticHeterogeneityDiffuse2013 -->
<!-- BL: loveGeneticLandscapeMutations2012 -->
<!-- FL: krysiakRecurrentSomaticMutations2017b -->
<!-- BL: loveGeneticLandscapeMutations2012 -->

[[include:mermaid_ARID1A.md]]

## References

<!-- PMBL: wienandGenomicAnalysesFlowsorted2019b -->