---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview

Mutations in this gene were first described in MZL by Braggio et al.[@braggioGenomicAnalysisMarginal2012] then in MCL by Bea et al.[@beaLandscapeSomaticMutations2013] ATM mutations were later described in DLBCL by Reddy et al.[@reddyGeneticFunctionalDrivers2017]



## Relevance tier by entity

|Entity|Tier|Description               |
|:------:|:----:|--------------------------|
|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene[@braggioGenomicAnalysisMarginal2012]|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene[@reddyGeneticFunctionalDrivers2017; @arthurGenomewideDiscoverySomatic2018]|
|![MCL](images/icons/MCL_tier1.png)   |1   |high-confidence MCL gene  [@beaLandscapeSomaticMutations2013]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_ATM.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_ATM.md]]


[[include:browser_ATM.md]]

## Expression
![](images/gene_expression/ATM_by_pathology.svg)

[[include:mermaid_ATM.md]]

## References


<!-- ORIGIN: braggioGenomicAnalysisMarginal2012 -->
<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->
<!-- MZL: braggioGenomicAnalysisMarginal2012 -->
<!-- MCL: beaLandscapeSomaticMutations2013 -->