---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Overview

Due to [minimal support](CAD#representative-mutation) in the original primary data and very few mutations reported in subsequent studies, this gene is very unlikely to be relevant in BL. 


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![BL](images/icons/BL_tier2.png)    |3   |Retired, Failed QC[@loveGeneticLandscapeMutations2012]|

## Warnings

<<Warn("The variants reported in this gene failed QC")>>

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source               |frequency (%)|
|:------:|:---------------------:|:-------------:|
|BL    |GAMBL genomes+capture|3.93         |
|BL    |Thomas cohort        |  NA         |
|BL    |Panea cohort         |  NA         |

## Mutation pattern and selective pressure estimates

[[include:dnds_CAD.md]]




## CAD Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr2 | 27455966 | T>A | Y983* |

[[include:browser_CAD.md]]

## Expression
![](images/gene_expression/CAD_by_pathology.svg)
<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->
<!-- BL: loveGeneticLandscapeMutations2012 -->

## Representative Mutation
![](primary/Love_CAD.svg)
**Rating**
&starf; &star; &star; &star; &star;

## All Mutations

[1064](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/1064_reports.html)
[1102](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/1102_reports.html)
[479](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/479_reports.html)
[479](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/479_reports.html)

[[include:mermaid_CAD.md]]

## References