---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]



## Overview

Due to [minimal support](CCT6B#representative-mutations) in the original primary data and very few mutations reported in subsequent studies, this gene is very unlikely to be relevant in BL. 


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![BL](images/icons/BL_tier2.png)    |3   |Retired, Failed QC[@loveGeneticLandscapeMutations2012]|

## Warnings

<<Warn("The variants reported in this gene failed QC")>>

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source               |frequency (%)|
|:------:|:---------------------:|:-------------:|
|BL    |GAMBL genomes+capture|1.15         |
|BL    |Thomas cohort        |  NA         |
|BL    |Panea cohort         |  NA         |

## Mutation pattern and selective pressure estimates

[[include:dnds_CCT6B.md]]




[[include:browser_CCT6B.md]]

## Expression
![](images/gene_expression/CCT6B_by_pathology.svg)
<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->
<!-- BL: loveGeneticLandscapeMutations2012 -->

## Representative Mutation
![](primary/Love_CCT6B.svg)
**Although well supported in the data, this mutation is clearly germline**

## All Mutations

[1096](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/1096_reports.html)
[1102](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/1102_reports.html)
[508](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/508_reports.html)
[515](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/515_reports.html)
[670](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/670_reports.html)

[[include:mermaid_CCT6B.md]]

## References