---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview
the CD274 gene encodes the programmed death-ligand 1 (PD-L1). Mutations in B-cell lymphomas, such as DLBCL, are relatively rare.
Although rare, mutations have the potential to impact PD-L1 expression and could be relevant in the context of immune checkpoint inhibitors. 


## Relevance tier by entity

|Entity|Tier|Description               |
|:------:|:----:|--------------------------|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene[@morinFrequentMutationHistonemodifying2011]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |0.96         |
|DLBCL |Schmitz cohort|2.34         |
|DLBCL |Reddy cohort  |1.30         |
|DLBCL |Chapuy cohort |2.56         |

## Mutation pattern and selective pressure estimates

[[include:dnds_CD274.md]]




[[include:browser_CD274.md]]

## Expression
![](images/gene_expression/CD274_by_pathology.svg)

[[include:mermaid_CD274.md]]

## References


<!-- ORIGIN: morinFrequentMutationHistonemodifying2011 -->
<!-- DLBCL: morinFrequentMutationHistonemodifying2011 -->