---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview

CD36 is a transmembrane glycoprotein involved in fatty acid metabolism, glucose intolerance, and immune responses. It is expressed on various cell types, including platelets, monocytes, and some lymphocytes. One study showed higher rates of CD36 mutations in FL relative to DLBCLs.[@pasqualucciAnalysisCodingGenome2011]


## Relevance tier by entity

|Entity|Tier|Description               |
|:------:|:----:|--------------------------|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene[@pasqualucciAnalysisCodingGenome2011]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |2.29         |
|DLBCL |Schmitz cohort|4.89         |
|DLBCL |Reddy cohort  |2.80         |
|DLBCL |Chapuy cohort |2.99         |

## Mutation pattern and selective pressure estimates

[[include:dnds_CD36.md]]


## Expression
![](images/gene_expression/CD36_by_pathology.svg)
<!-- ORIGIN: pasqualucciAnalysisCodingGenome2011 -->
<!-- DLBCL: pasqualucciAnalysisCodingGenome2011 -->

[[include:browser_CD36.md]]