---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]



## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![DLBCL](images/icons/DLBCL_tier2.png) |2 | aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous [@arthurGenomewideDiscoverySomatic2018]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |0.19         |
|DLBCL |Schmitz cohort|1.49         |
|DLBCL |Reddy cohort  |1.40         |
|DLBCL |Chapuy cohort |2.14         |

## Mutation pattern and selective pressure estimates

[[include:dnds_CD44.md]]

## aSHM regions

|chr_name|hg19_start|hg19_end|region                                                                                    |regulatory_comment|
|:--------:|:----------:|:--------:|:------------------------------------------------------------------------------------------:|:------------------:|
|chr11   |35156769  |35164248|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr11%3A35156769%2D35164248)|active_promoter   |



[[include:browser_CD44.md]]

## Expression
![](images/gene_expression/CD44_by_pathology.svg)
<!-- ORIGIN: arthurGenomewideDiscoverySomatic2018 -->
<!-- DLBCL: arthurGenomewideDiscoverySomatic2018 -->

[[include:mermaid_CD44.md]]

## References