---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview

CD58, also known as lymphocyte function-associated antigen 3 (LFA-3), is crucial for immune recognition, facilitating interactions between tumor cells and cytotoxic T cells and natural killer (NK) cells. 

## Experimental Evidence

In DLBCL, mutations prevent the expression of CD58 on the cell surface, impairing the ability of T and NK cells to recognize and attack the tumor cells. 
This is often accompanied by mutations in the β2-Microglobulin gene, which further aids in immune evasion.[@challa-malladiCombinedGeneticInactivation2011]


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene[@schneiderAlterationsCD58Gene2015]|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene            [@morinFrequentMutationHistonemodifying2011]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_CD58.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_CD58.md]]

[[include:browser_CD58.md]]

## Expression
![](images/gene_expression/CD58_by_pathology.svg)

[[include:mermaid_CD58.md]]

## References

<!-- ORIGIN: schneiderAlterationsCD58Gene2015a -->
<!-- DLBCL: morinFrequentMutationHistonemodifying2011 -->
<!-- PMBL: schneiderAlterationsCD58Gene2015a -->