---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview

Mutations in this gene were first described in FL in 2021 by Hübschmann et al.[@hubschmannMutationalMechanismsShaping2021]


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![FL](images/icons/FL_tier2.png)    |2   |relevance in FL not firmly established[@hubschmannMutationalMechanismsShaping2021]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source       |frequency (%)|
|:------:|:-------------:|:-------------:|
|FL    |GAMBL genomes|2.08         |

## Mutation pattern and selective pressure estimates

[[include:dnds_CPNE8.md]]




[[include:browser_CPNE8.md]]

## Expression
![](images/gene_expression/CPNE8_by_pathology.svg)

## All Mutations

[SP192870](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP192870.html)
[SP116694](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP116694.html)
[SP193954](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP193954.html)
[SP193150](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP193150.html)
[SP116720](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP116720.html)

[[include:mermaid_CPNE8.md]]

## References

<!-- ORIGIN: hubschmannMutationalMechanismsShaping2021b -->
<!-- FL: hubschmannMutationalMechanismsShaping2021b -->