---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]



## Relevance tier by entity

|Entity|Tier|Description            |
|:------:|:----:|-----------------------|
|![FL](images/icons/FL_tier1.png)    |1   |high-confidence FL gene[@barariaCathepsinAlterationsInduce2020]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

[[include:DLBCL_CTSS.md]]
[[include:FL_CTSS.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_CTSS.md]]

## CTSS Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr1 | 150727482 | A>C | Y132D |
| chr1 | 150727482 | A>T | Y132N |

[[include:browser_CTSS.md]]

## Expression
![](images/gene_expression/CTSS_by_pathology.svg)
<!-- ORIGIN: barariaCathepsinAlterationsInduce2020c -->
<!-- FL: barariaCathepsinAlterationsInduce2020c -->

[[include:mermaid_CTSS.md]]

## References