CXCR4

CXCR4

Overview

CXCR4 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. No notable hot spots have been described in this gene in the context of the cancers listed below. The mutation pattern in DLBCL implies the preferential accumulation of inactivating mutations.

Relevance tier by entity

Entity	Tier	Description
DLBCL	1-a	aSHM target and high-confidence DLBCL gene
FL	2-a	aSHM target; Although recurrent, the relevance of mutations in FL is tenuous
BL	2-a	aSHM target; Although recurrent, the relevance of mutations in BL is tenuous

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
BL	GAMBL genomes+capture	2.08
BL	Thomas cohort	2.10
BL	Panea cohort	2.00
DLBCL	GAMBL genomes	2.87
DLBCL	Schmitz cohort	2.55
DLBCL	Reddy cohort	1.50
DLBCL	Chapuy cohort	2.56
FL	GAMBL genomes	3.46

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	Yes	No	4.603	0.000
DLBCL	Yes	No	3.731	18.727
FL	Yes	No	0.000	0.000

aSHM regions

chr_name	hg19_start	hg19_end	region	regulatory_comment
chr2	136874728	136875461	intron	weak_promoter

Note

First described in BL in 2019 by Panea RI. First described in DLBCL in 2012 by Khodabakhshi AH. First described in FL in 2021 by Hübschmann D

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

CXCR4 Expression