---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
nocite: |
  @loveGeneticLandscapeMutations2012, 
---
[[_TOC_]]

## Overview

Due to [minimal support](CYP4F22#representative-mutation) in the original primary data, [low expression in BL](CYP4F22#cyp4f22-expression) and no mutations reported in subsequent studies, this gene is very unlikely to be relevant in BL. 



## Relevance tier by entity

[[include:tables/table1_CYP4F22.md]]

## Warnings

<<Warn("The variants reported in this gene failed QC")>>

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source               |frequency (%)|
|:------:|:---------------------:|:-------------:|
|BL    |GAMBL genomes+capture|1.39         |
|BL    |Thomas cohort        |  NA         |
|BL    |Panea cohort         |  NA         |

## Mutation pattern and selective pressure estimates

[[include:tables/dnds_CYP4F22.md]]


[[include:tables/browser_CYP4F22.md]]

## Expression
![](images/gene_expression/CYP4F22_by_pathology.svg)
<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->
<!-- BL: loveGeneticLandscapeMutations2012 -->

## Representative mutation

![](primary/Love_CYP4F22_15523136.png)
**Rating**
&starf; &star; &star; &star; &star;

## All Mutations

[1060](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/1060_reports.html)
[1066](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/1066_reports.html)
[515](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/515_reports.html)
[699](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/699_reports.html)
[747](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/747_reports.html)


[[include:tables/mermaid_CYP4F22.md]]

## References