---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]





## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![DLBCL](images/icons/DLBCL_tier2.png) |3  |Retired, Failed QC[@reddyGeneticFunctionalDrivers2017]|

## Warnings

<<Warn("The variants reported in this gene in DLBCL failed QC")>>

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |0.76         |
|DLBCL |Schmitz cohort|2.13         |
|DLBCL |Reddy cohort  |1.40         |
|DLBCL |Chapuy cohort |1.28         |

## Mutation pattern and selective pressure estimates

[[include:dnds_DNMT3A.md]]




[[include:browser_DNMT3A.md]]

## Expression
![](images/gene_expression/DNMT3A_by_pathology.svg)
<!-- ORIGIN: reddyGeneticFunctionalDrivers2017 -->
<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->

[[include:mermaid_DNMT3A.md]]

## References