DUSP2

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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

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Overview

DUSP2 functions as a negative regulator of MAPK signaling, particularly affecting the ERK1/2 pathway. DUSP2 mutations have been reported in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), T-cell/histiocyte-rich large B-cell lymphoma (T/HRLBCL)[@schuhmacherJUNBDUSP2SGK12019; @hartmannHighlyRecurrentMutations2016] and they are relatively frequent in DLBCL.
DUSP2 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. These mutations are associated with the ST2 genetic subgroup of DLBCL. This gene has some recurrent sites of mutations (hot spots). The mutation pattern in DLBCL implies the preferential accumulation of inactivating mutations.

Relevance tier by entity

Entity	Tier	Description
	1	high-confidence PMBL/cHL/GZL gene[@dunsCharacterizationDLBCLPMBL2021]
	1	aSHM target and high-confidence DLBCL gene [@morinMutationalStructuralAnalysis2013; @lohrDiscoveryPrioritizationSomatic2012]
	2	aSHM target; Although recurrent, the relevance of mutations in FL is tenuous

Mutation incidence in large patient cohorts (GAMBL reanalysis)

include:DLBCL_DUSP2.md include:FL_DUSP2.md

Mutation pattern and selective pressure estimates

include:dnds_DUSP2.md

aSHM regions

chr_name	hg19_start	hg19_end	region	regulatory_comment
chr2	96808901	96811913	intron-1	enhancer

DUSP2 Hotspots

Chromosome	Coordinate (hg19)	ref>alt	HGVSp
chr2	96810877	C>G	D73H
chr2	96810865	G>A	R77W
chr2	96810842	C>G	E84D
chr2	96810841	G>C	L85V
chr2	96810730	G>A	P122S
chr2	96810717	T>C	Y126C
chr2	96810706	C>T	G130R
chr2	96810597	C>T	C138Y
chr2	96810582	C>T	C143Y
chr2	96810574	C>T	A146T

include:browser_DUSP2.md

Expression

include:mermaid_DUSP2.md

References