---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established[@parryWholeExomeSequencing2013]|
|![DLBCL](images/icons/DLBCL_tier2.png) |2   |relevance in DLBCL not firmly established[@morinMutationalStructuralAnalysis2013]|
|![MCL](images/icons/MCL_tier2.png)   |2   |relevance in MCL not firmly established  [@zhangGenomicLandscapeMantle2014]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |12.81        |
|DLBCL |Schmitz cohort|20.43        |
|DLBCL |Reddy cohort  |14.91        |
|DLBCL |Chapuy cohort |16.67        |
|MCL   |GAMBL genomes | 3.79        |

## Mutation pattern and selective pressure estimates

[[include:dnds_FAT4.md]]




[[include:browser_FAT4.md]]

## Expression
![](images/gene_expression/FAT4_by_pathology.svg)
<!-- ORIGIN: morinMutationalStructuralAnalysis2013 -->
<!-- DLBCL: morinMutationalStructuralAnalysis2013 -->
<!-- MCL: zhangGenomicLandscapeMantle2014 -->
<!-- MZL: parryWholeExomeSequencing2013 -->

## All Mutations

### DLBCL

[RG014](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG014.html)
[RG038](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG038.html)
[RG043](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG043.html)
[RG055](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG055.html)
[RG077](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG077.html)
[RG081](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG081.html)
[RG111](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG111.html)

[[include:mermaid_FAT4.md]]

## References