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rdmorin edited this page Jul 25, 2024 · 32 revisions

title: 'FL genes' bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

Origins of FL genes

Tier 1 FL genes

66 total

Gene Summary First FL study Other entities QC result
ACTB Tier 1 GE [@lohrDiscoveryPrioritizationSomatic2012a; @wienandGenomicAnalysesFlowsorted2019b]
ARID1A Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], FE[@barisicARID1AOrchestratesSWI2024] Krysiak et al [@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @wienandGenomicAnalysesFlowsorted2019b; @zhangGeneticHeterogeneityDiffuse2013]
ATP6AP1 Tier 1 GE[@okosunRecurrentMTORC1activatingRRAGC2016a] Okosun et al
ATP6V1B2 Tier 1 GE[@okosunRecurrentMTORC1activatingRRAGC2016a] Okosun et al
B2M Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@challa-malladiCombinedGeneticInactivationa] Morin et al [@pararajalingamCodingNoncodingDrivers2020; @reichelFlowSortingExome2015a]
BCL2 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@balSuperenhancerHypermutationAlters2022] Morin et al [@burkhardtClinicalRelevanceMolecular2022b; @sarkozyMutationalLandscapeGray2021a; @tanakaFrequentIncidenceSomatic1992]
BCL6 Tier 1 GE, FE[@balSuperenhancerHypermutationAlters2022] [@loveGeneticLandscapeMutations2012; @morinFrequentMutationHistonemodifying2011]
BCL7A Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], FE[@balinas-gaviraFrequentMutationsAminoterminal2020b] Krysiak et al [@grandeGenomewideDiscoverySomatic2019; @morinFrequentMutationHistonemodifying2011; @reichelFlowSortingExome2015a]
BIRC6 Tier 1 GE [@reddyGeneticFunctionalDrivers2017; @sarkozyMutationalLandscapeGray2021a]
BTG1 Tier 1 GE, FE[@mlynarczykBTG1MutationYields2023b] [@burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011; @sarkozyMutationalLandscapeGray2021a]
BTG2 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], CE[@guoMutationBTG2Gene2022b] Morin et al [@loveGeneticLandscapeMutations2012]
BTK Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@albuquerqueEnhancingKnowledgeDiscovery2017a]
CARD11 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@lenzOncogenicCARD11Mutations2008], CE[@zhaoExpressionPrognosticValue2016] Morin et al [@lenzOncogenicCARD11Mutations2008; @wuGeneticHeterogeneityPrimary2016; @yanBCRTLRSignaling2012a]
CCND3 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@schmitzBurkittLymphomaPathogenesis2012] Morin et al [@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @richterRecurrentMutationID32012a]
CD83 Tier 1 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al [@dunsCharacterizationDLBCLPMBL2021b; @morinMutationalStructuralAnalysis2013; @paneaWholeGenomeLandscape2019]
CREBBP Tier 1 GE[@pasqualucciInactivatingMutationsAcetyltransferase2011a], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011a] Pasqualucci et al [@dunsCharacterizationDLBCLPMBL2021b; @loveGeneticLandscapeMutations2012; @parryWholeExomeSequencing2013]
CTSS Tier 1 GE[@barariaCathepsinAlterationsInduce2020c] Bararia et al
DTX1 Tier 1 GE, FE[@demirandaExomeSequencingReveals2014], CE[@merirantaDeltex1MutationsPredict2017b] [@gomezUltraDeepSequencingReveals2023; @loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @zhangGeneticHeterogeneityDiffuse2013]
EBF1 Tier 1 GE [@bohleRoleEarlyBcell2013; @reichelFlowSortingExome2015a; @thomasGeneticSubgroupsInform2023]
EEF1A1 Tier 1 GE[@hubschmannMutationalMechanismsShaping2021b], CE[@gongExpressionClinicalValue2021] Hubschmann et al [@reichelFlowSortingExome2015a]
EP300 Tier 1 GE[@pasqualucciInactivatingMutationsAcetyltransferase2011a], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011a] Pasqualucci et al [@rossiCodingGenomeSplenic2012c]
EZH2 Tier 1 GE[@morinSomaticMutationsAltering2010a], FE[@yapSomaticMutationsEZH22011b] Morin et al [@loveGeneticLandscapeMutations2012; @mottokIntegrativeGenomicAnalysis2019b]
FAS Tier 1 GE, FE[@seebergerLossFasCD952001] [@schollMutationsRegionFAS2007; @spinaGeneticsNodalMarginal2016b]
FOXO1 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@trinhAnalysisFOXO1Mutations], CE[@trinhAnalysisFOXO1Mutations] Morin et al [@dunsCharacterizationDLBCLPMBL2021b; @schmitzBurkittLymphomaPathogenesis2012]
GNA13 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@muppidiLossSignalingGa132014b] Morin et al [@loveGeneticLandscapeMutations2012; @reichelFlowSortingExome2015a]
GNAI2 Tier 1 GE [@grandeGenomewideDiscoverySomatic2019; @morinMutationalStructuralAnalysis2013]
HIST1H1B Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@chapuyMolecularSubtypesDiffuse2018b; @sarkozyMutationalLandscapeGray2021a]
HIST1H1C Tier 1 GE[@morinFrequentMutationHistonemodifying2011] Morin et al [@paneaWholeGenomeLandscape2019]
HIST1H1D Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@jalladesExomeSequencingIdentifies2017; @morinMutationalStructuralAnalysis2013]
HIST1H1E Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@grandeGenomewideDiscoverySomatic2019; @lohrDiscoveryPrioritizationSomatic2012a; @reichelFlowSortingExome2015a]
HIST1H2AC Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@morinMutationalStructuralAnalysis2013]
HIST1H2AG Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@morinMutationalStructuralAnalysis2013; @paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012c]
HIST1H2AM Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@chapuyMolecularSubtypesDiffuse2018b; @paneaWholeGenomeLandscape2019]
HIST1H2BC Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@lohrDiscoveryPrioritizationSomatic2012a; @mottokIntegrativeGenomicAnalysis2019b]
HIST1H2BD Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al
HIST1H2BG Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al
HIST1H3B Tier 1 GE [@lohrDiscoveryPrioritizationSomatic2012a; @reichelFlowSortingExome2015a]
HIST1H3G Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al
HVCN1 Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@chapuyMolecularSubtypesDiffuse2018b]
IRF4 Tier 1 GE [@morinFrequentMutationHistonemodifying2011; @mottokIntegrativeGenomicAnalysis2019b]
IRF8 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@qiuIRF8mutantCellLymphoma2024] Morin et al [@mottokIntegrativeGenomicAnalysis2019b; @paneaWholeGenomeLandscape2019]
ITPKB Tier 1 GE [@reichelFlowSortingExome2015a; @schmitzGeneticsPathogenesisDiffuse2018a]
KLF2 Tier 1 GE [@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @pasqualucciAnalysisCodingGenome2011]
KLHL6 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@merirantaDisruptionKLHL6Fuels2024] Morin et al [@ganapathiGeneticLandscapeDural2016]
KMT2D Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@liLossCREBBPKMT2D2024], CE[@rushtonGeneticEvolutionaryPatterns2020] Morin et al [@beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c]
LTB Tier 1 GE [@chapuyMolecularSubtypesDiffuse2018b; @deschGenotypingCirculatingTumor2020]
MAP2K1 Tier 1 GE[@louissaintPediatrictypeNodalFollicular2016a] Louissaint et al [@shinBRAFV600EMAP2K12015]
MEF2B Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@yingMEF2BMutationsLead] Morin et al [@beaLandscapeSomaticMutations2013]
MEF2C Tier 1 GE, FE[@jingjingNovelMEF2CMutation2020] [@arthurGenomewideDiscoverySomatic2018]
PCLO Tier 1 GE [@lohrDiscoveryPrioritizationSomatic2012a]
PIM1 Tier 1 GE, CE[@guoSGK1MutationStatus2022b] [@burkhardtClinicalRelevanceMolecular2022b; @dunsCharacterizationDLBCLPMBL2021b; @pasqualucciHypermutationMultipleProtooncogenes2001a]
POU2AF1 Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@chapuyMolecularSubtypesDiffuse2018b]
POU2F2 Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], FE[@hodsonRegulationNormalBcell2016a] Krysiak et al [@lohrDiscoveryPrioritizationSomatic2012a]
PTPRD Tier 1 GE [@spinaGeneticsNodalMarginal2016b]
RRAGC Tier 1 GE, FE[@ortega-molinaOncogenicRagGTPase2019b] [@okosunRecurrentMTORC1activatingRRAGC2016a]
S1PR2 Tier 1 GE, FE[@floriHematopoieticOncoproteinFOXP12016] [@morinFrequentMutationHistonemodifying2011; @muppidiLossSignalingGa132014b]
SGK1 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@hartmannHighlyRecurrentMutations2016b], CE[@guoSGK1MutationStatus2022b] Morin et al [@dunsCharacterizationDLBCLPMBL2021b]
SMARCA4 Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], FE[@dengSMARCA4HaploinsufficientCell2024] Krysiak et al [@nadeuGenomicEpigenomicInsights2020b; @reddyGeneticFunctionalDrivers2017; @richterRecurrentMutationID32012a]
SOCS1 Tier 1 GE, FE[@melznerBiallelicMutationSOCS12005a] [@morinFrequentMutationHistonemodifying2011; @wenigerMutationsTumorSuppressor2006a]
STAT6 Tier 1 GE[@yildizActivatingSTAT6Mutations2015c], FE[@yildizActivatingSTAT6Mutations2015c] Yildiz et al [@ritzRecurrentMutationsSTAT62009a]
TBL1XR1 Tier 1 GE, FE[@venturuttiTBL1XR1MutationsDrive2020b] [@lohrDiscoveryPrioritizationSomatic2012a; @rossiCodingGenomeSplenic2012c]
TMSB4X Tier 1 GE [@zhangGeneticHeterogeneityDiffuse2013]
TNFAIP3 Tier 1 GE, FE[@compagnoMutationsMultipleGenes2009a] [@compagnoMutationsMultipleGenes2009a; @rossiAlterationBIRC3Multiple2011a; @schmitzTNFAIP3A20Tumor2009a]
TNFRSF14 Tier 1 GE[@cheungAcquiredTNFRSF14Mutations2010a], CE[@guoSGK1MutationStatus2022b] Cheung et al [@morinFrequentMutationHistonemodifying2011; @spinaGeneticsNodalMarginal2016b]
TP53 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@rowhTp53DeletionLineage2011] Morin et al [@beaLandscapeSomaticMutations2013; @lohrDiscoveryPrioritizationSomatic2012a; @rossiCodingGenomeSplenic2012c; @tiacciPervasiveMutationsJAKSTAT2018b; @wildaInactivationARFMDM2p53Pathway2004]
VMA21 Tier 1 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al

Tier 2 FL genes

49 total

Gene Summary First FL study Other entities QC result
ABL2 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
ACTG1 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al [@deschGenotypingCirculatingTumor2020; @spinaGeneticsNodalMarginal2016b]
ATP6V1A Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
BCL10 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b], FE[@xiaBCL10MutationsDefine2022] Russler et al [@morinFrequentMutationHistonemodifying2011; @spinaGeneticsNodalMarginal2016b]
CD70 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al [@morinFrequentMutationHistonemodifying2011]
CD79B Tier 2 GE, FE[@davisChronicActiveBcellreceptor2010] [@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]
CDC42BPB Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al [@spinaGeneticsNodalMarginal2016b]
CILP Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
CPNE8 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
CXCR4 Tier 2 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@khodabakhshiRecurrentTargetsAberrant2012; @paneaWholeGenomeLandscape2019]
CYP2A6 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
DDX3X Tier 2 GE, FE[@gongSequentialInverseDysregulation2021], CE[@kizhakeyilDDX3XLossAdverse2021] [@mottokIntegrativeGenomicAnalysis2019b; @reddyGeneticFunctionalDrivers2017; @schmitzBurkittLymphomaPathogenesis2012]
DHX15 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
DUSP2 Tier 2 GE [@dunsCharacterizationDLBCLPMBL2021b; @lohrDiscoveryPrioritizationSomatic2012a]
EGR1 Tier 2 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@reichelFlowSortingExome2015a; @rossiCodingGenomeSplenic2012c]
FZR1 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
GBP7 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
GRM6 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
HIST1H2BM Tier 2 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al
HIST1H3I Tier 2 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@paneaWholeGenomeLandscape2019]
HLA-B Tier 2 GE [@lohrDiscoveryPrioritizationSomatic2012a; @wienandGenomicAnalysesFlowsorted2019b]
HNRNPD Tier 2 GE [@reddyGeneticFunctionalDrivers2017]
IGLL5 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al [@chapuyMolecularSubtypesDiffuse2018b; @deschGenotypingCirculatingTumor2020; @paneaWholeGenomeLandscape2019]
JUP Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
KIR3DL1 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
LAPTM5 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
MAGEC1 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
MAP7D1 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
MGEA5 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
MKI67 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al [@schmitzBurkittLymphomaPathogenesis2012]
MYC Tier 2 GE, FE[@giallongoIdentificationCmycOncogene1983], CE[@christieCMYCTranslocation142008] [@dunsCharacterizationDLBCLPMBL2021b; @jalladesExomeSequencingIdentifies2017; @johnstonCmycHypermutationBurkitt1992; @pasqualucciHypermutationMultipleProtooncogenes2001a]
MYCBP2 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
MYD88 Tier 2 GE, FE[@ngoOncogenicallyActiveMYD882011a], CE[@guoSGK1MutationStatus2022b] [@ngoOncogenicallyActiveMYD882011a; @yanBCRTLRSignaling2012a]
NFKBIA Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al [@thomasMutationalAnalysisIkappaBalpha2004; @wienandGenomicAnalysesFlowsorted2019b]
OR8H2 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
P2RY8 Tier 2 GE, FE[@muppidiLossSignalingGa132014b] [@lohrDiscoveryPrioritizationSomatic2012a; @muppidiLossSignalingGa132014b]
PDS5B Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al [@morinMutationalStructuralAnalysis2013]
PPP4C Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
PRKDC Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al [@schmitzGeneticsPathogenesisDiffuse2018a]
PZP Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
RBM6 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
SHROOM3 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
SRRM2 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al [@morinMutationalStructuralAnalysis2013]
STAB2 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
TMEM30A Tier 2 GE[@morinFrequentMutationHistonemodifying2011], FE[@ennishiTMEM30ALossoffunctionMutations2020b], CE[@ennishiTMEM30ALossoffunctionMutations2020b] Morin et al
TPP1 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
XIRP2 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
ZC3H12A Tier 2 GE [@chapuyMolecularSubtypesDiffuse2018b]
ZNF608 Tier 2 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@morinMutationalStructuralAnalysis2013]

Tier 3 FL genes

0 total

Gene Summary First FL study Other entities QC result

References

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