Skip to content

FL_genes

Jump to bottom
rdmorin edited this page Jul 25, 2024 · 32 revisions

title: 'FL genes' bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

Origins of FL genes

Tier 1 FL genes

49 total

Gene Summary First FL study Other entities QC result
ARID1A Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], FE[@barisicARID1AOrchestratesSWI2024] Krysiak et al [@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @wienandGenomicAnalysesFlowsorted2019b; @zhangGeneticHeterogeneityDiffuse2013]
ATP6AP1 Tier 1 GE[@okosunRecurrentMTORC1activatingRRAGC2016a] Okosun et al
ATP6V1B2 Tier 1 GE[@okosunRecurrentMTORC1activatingRRAGC2016a] Okosun et al
B2M Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@challa-malladiCombinedGeneticInactivationa] Morin et al [@pararajalingamCodingNoncodingDrivers2020; @reichelFlowSortingExome2015a]
BCL2 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@balSuperenhancerHypermutationAlters2022] Morin et al [@burkhardtClinicalRelevanceMolecular2022b; @sarkozyMutationalLandscapeGray2021a; @tanakaFrequentIncidenceSomatic1992]
BCL7A Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], FE[@balinas-gaviraFrequentMutationsAminoterminal2020b] Krysiak et al [@grandeGenomewideDiscoverySomatic2019; @morinFrequentMutationHistonemodifying2011; @reichelFlowSortingExome2015a]
BTK Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@albuquerqueEnhancingKnowledgeDiscovery2017a]
CARD11 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@lenzOncogenicCARD11Mutations2008], CE[@zhaoExpressionPrognosticValue2016] Morin et al [@lenzOncogenicCARD11Mutations2008; @wuGeneticHeterogeneityPrimary2016; @yanBCRTLRSignaling2012a]
CCND3 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@schmitzBurkittLymphomaPathogenesis2012] Morin et al [@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @richterRecurrentMutationID32012a]
CD83 Tier 1 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al [@dunsCharacterizationDLBCLPMBL2021b; @morinMutationalStructuralAnalysis2013; @paneaWholeGenomeLandscape2019]
CREBBP Tier 1 GE[@pasqualucciInactivatingMutationsAcetyltransferase2011a], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011a] Pasqualucci et al [@dunsCharacterizationDLBCLPMBL2021b; @loveGeneticLandscapeMutations2012; @parryWholeExomeSequencing2013]
CTSS Tier 1 GE[@barariaCathepsinAlterationsInduce2020c] Bararia et al
EEF1A1 Tier 1 GE[@hubschmannMutationalMechanismsShaping2021b], CE[@gongExpressionClinicalValue2021] Hubschmann et al [@reichelFlowSortingExome2015a]
EP300 Tier 1 GE[@pasqualucciInactivatingMutationsAcetyltransferase2011a], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011a] Pasqualucci et al [@rossiCodingGenomeSplenic2012c]
EZH2 Tier 1 GE[@morinSomaticMutationsAltering2010a], FE[@yapSomaticMutationsEZH22011b] Morin et al [@loveGeneticLandscapeMutations2012; @mottokIntegrativeGenomicAnalysis2019b]
FOXO1 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@trinhAnalysisFOXO1Mutations], CE[@trinhAnalysisFOXO1Mutations] Morin et al [@dunsCharacterizationDLBCLPMBL2021b; @schmitzBurkittLymphomaPathogenesis2012]
GNA13 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@muppidiLossSignalingGa132014b] Morin et al [@loveGeneticLandscapeMutations2012; @reichelFlowSortingExome2015a]
HIST1H1B Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@chapuyMolecularSubtypesDiffuse2018b; @sarkozyMutationalLandscapeGray2021a]
HIST1H1C Tier 1 GE[@morinFrequentMutationHistonemodifying2011] Morin et al [@paneaWholeGenomeLandscape2019]
HIST1H1D Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@jalladesExomeSequencingIdentifies2017; @morinMutationalStructuralAnalysis2013]
HIST1H1E Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@grandeGenomewideDiscoverySomatic2019; @lohrDiscoveryPrioritizationSomatic2012a; @reichelFlowSortingExome2015a]
HIST1H2AC Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@morinMutationalStructuralAnalysis2013]
HIST1H2AG Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@morinMutationalStructuralAnalysis2013; @paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012c]
HIST1H2AM Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@chapuyMolecularSubtypesDiffuse2018b; @paneaWholeGenomeLandscape2019]
HIST1H2BC Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@lohrDiscoveryPrioritizationSomatic2012a; @mottokIntegrativeGenomicAnalysis2019b]
HIST1H2BD Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al
HIST1H2BG Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al
HIST1H3B Tier 1 GE [@lohrDiscoveryPrioritizationSomatic2012a; @reichelFlowSortingExome2015a]
HIST1H3G Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al
HVCN1 Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@chapuyMolecularSubtypesDiffuse2018b]
IRF4 Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023] Dreval et al [@morinFrequentMutationHistonemodifying2011; @mottokIntegrativeGenomicAnalysis2019b]
IRF8 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@qiuIRF8mutantCellLymphoma2024] Morin et al [@mottokIntegrativeGenomicAnalysis2019b; @paneaWholeGenomeLandscape2019]
KLHL6 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@merirantaDisruptionKLHL6Fuels2024] Morin et al [@ganapathiGeneticLandscapeDural2016]
KMT2D Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@liLossCREBBPKMT2D2024], CE[@rushtonGeneticEvolutionaryPatterns2020] Morin et al [@beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c]
MAP2K1 Tier 1 GE[@louissaintPediatrictypeNodalFollicular2016a] Louissaint et al [@shinBRAFV600EMAP2K12015]
MEF2B Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@yingMEF2BMutationsLead] Morin et al [@beaLandscapeSomaticMutations2013]
PIM1 Tier 1 GE[@drevalGeneticSubdivisionsFollicular2023], CE[@guoSGK1MutationStatus2022b] Dreval et al [@burkhardtClinicalRelevanceMolecular2022b; @dunsCharacterizationDLBCLPMBL2021b; @pasqualucciHypermutationMultipleProtooncogenes2001a]
POU2AF1 Tier 1 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@chapuyMolecularSubtypesDiffuse2018b]
POU2F2 Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], FE[@hodsonRegulationNormalBcell2016a] Krysiak et al [@lohrDiscoveryPrioritizationSomatic2012a]
RRAGC Tier 1 GE[@okosunRecurrentMTORC1activatingRRAGC2016a], FE[@ortega-molinaOncogenicRagGTPase2019b] Okosun et al
SGK1 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@hartmannHighlyRecurrentMutations2016b], CE[@guoSGK1MutationStatus2022b] Morin et al [@dunsCharacterizationDLBCLPMBL2021b]
SMARCA4 Tier 1 GE[@krysiakRecurrentSomaticMutations2017b], FE[@dengSMARCA4HaploinsufficientCell2024] Krysiak et al [@nadeuGenomicEpigenomicInsights2020b; @reddyGeneticFunctionalDrivers2017; @richterRecurrentMutationID32012a]
STAT6 Tier 1 GE[@yildizActivatingSTAT6Mutations2015c], FE[@yildizActivatingSTAT6Mutations2015c] Yildiz et al [@ritzRecurrentMutationsSTAT62009a]
TBL1XR1 Tier 1 GE, FE[@venturuttiTBL1XR1MutationsDrive2020b] [@lohrDiscoveryPrioritizationSomatic2012a; @rossiCodingGenomeSplenic2012c]
TMSB4X Tier 1 GE [@zhangGeneticHeterogeneityDiffuse2013]
TNFAIP3 Tier 1 GE, FE[@compagnoMutationsMultipleGenes2009a] [@compagnoMutationsMultipleGenes2009a; @rossiAlterationBIRC3Multiple2011a; @schmitzTNFAIP3A20Tumor2009a]
TNFRSF14 Tier 1 GE[@cheungAcquiredTNFRSF14Mutations2010a], CE[@guoSGK1MutationStatus2022b] Cheung et al [@morinFrequentMutationHistonemodifying2011; @spinaGeneticsNodalMarginal2016b]
TP53 Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@rowhTp53DeletionLineage2011] Morin et al [@beaLandscapeSomaticMutations2013; @lohrDiscoveryPrioritizationSomatic2012a; @rossiCodingGenomeSplenic2012c; @tiacciPervasiveMutationsJAKSTAT2018b; @wildaInactivationARFMDM2p53Pathway2004]
VMA21 Tier 1 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al

Tier 2 FL genes

64 total

Gene Summary First FL study Other entities QC result
ABL2 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
ACTB Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023] Dreval et al [@lohrDiscoveryPrioritizationSomatic2012a; @wienandGenomicAnalysesFlowsorted2019b]
ACTG1 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al [@deschGenotypingCirculatingTumor2020; @spinaGeneticsNodalMarginal2016b]
ATP6V1A Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
BCL10 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b], FE[@xiaBCL10MutationsDefine2022] Russler et al [@morinFrequentMutationHistonemodifying2011; @spinaGeneticsNodalMarginal2016b]
BCL6 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@balSuperenhancerHypermutationAlters2022] Dreval et al [@loveGeneticLandscapeMutations2012; @morinFrequentMutationHistonemodifying2011]
BIRC6 Tier 2 GE [@reddyGeneticFunctionalDrivers2017; @sarkozyMutationalLandscapeGray2021a]
BTG1 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@mlynarczykBTG1MutationYields2023b] Dreval et al [@burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011; @sarkozyMutationalLandscapeGray2021a]
BTG2 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], CE[@guoMutationBTG2Gene2022b] Dreval et al [@loveGeneticLandscapeMutations2012; @morinFrequentMutationHistonemodifying2011]
CD70 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al [@morinFrequentMutationHistonemodifying2011]
CD79B Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@davisChronicActiveBcellreceptor2010] Dreval et al [@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]
CDC42BPB Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al [@spinaGeneticsNodalMarginal2016b]
CILP Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
CPNE8 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
CXCR4 Tier 2 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@khodabakhshiRecurrentTargetsAberrant2012; @paneaWholeGenomeLandscape2019]
CYP2A6 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
DDX3X Tier 2 GE, FE[@gongSequentialInverseDysregulation2021], CE[@kizhakeyilDDX3XLossAdverse2021] [@mottokIntegrativeGenomicAnalysis2019b; @reddyGeneticFunctionalDrivers2017; @schmitzBurkittLymphomaPathogenesis2012]
DHX15 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
DTX1 Tier 2 GE, FE[@demirandaExomeSequencingReveals2014], CE[@merirantaDeltex1MutationsPredict2017b] [@gomezUltraDeepSequencingReveals2023; @loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @zhangGeneticHeterogeneityDiffuse2013]
DUSP2 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023] Dreval et al [@dunsCharacterizationDLBCLPMBL2021b; @lohrDiscoveryPrioritizationSomatic2012a]
EBF1 Tier 2 GE [@bohleRoleEarlyBcell2013; @reichelFlowSortingExome2015a; @thomasGeneticSubgroupsInform2023]
EGR1 Tier 2 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@reichelFlowSortingExome2015a; @rossiCodingGenomeSplenic2012c]
FAS Tier 2 GE, FE[@seebergerLossFasCD952001] [@schollMutationsRegionFAS2007; @spinaGeneticsNodalMarginal2016b]
FZR1 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
GBP7 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
GNAI2 Tier 2 GE [@grandeGenomewideDiscoverySomatic2019; @morinMutationalStructuralAnalysis2013]
GRM6 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
HIST1H2BM Tier 2 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al
HIST1H3I Tier 2 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@paneaWholeGenomeLandscape2019]
HLA-B Tier 2 GE [@lohrDiscoveryPrioritizationSomatic2012a; @wienandGenomicAnalysesFlowsorted2019b]
IGLL5 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al [@chapuyMolecularSubtypesDiffuse2018b; @deschGenotypingCirculatingTumor2020; @paneaWholeGenomeLandscape2019]
ITPKB Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023] Dreval et al [@reichelFlowSortingExome2015a; @schmitzGeneticsPathogenesisDiffuse2018a]
JUP Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
KIR3DL1 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
KLF2 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023] Dreval et al [@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @pasqualucciAnalysisCodingGenome2011]
LAPTM5 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
LTB Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023] Dreval et al [@chapuyMolecularSubtypesDiffuse2018b; @deschGenotypingCirculatingTumor2020]
MAGEC1 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
MAP7D1 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
MEF2C Tier 2 GE, FE[@jingjingNovelMEF2CMutation2020] [@arthurGenomewideDiscoverySomatic2018]
MGEA5 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
MKI67 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al [@schmitzBurkittLymphomaPathogenesis2012]
MYC Tier 2 GE, FE[@giallongoIdentificationCmycOncogene1983], CE[@christieCMYCTranslocation142008] [@dunsCharacterizationDLBCLPMBL2021b; @jalladesExomeSequencingIdentifies2017; @johnstonCmycHypermutationBurkitt1992; @pasqualucciHypermutationMultipleProtooncogenes2001a]
MYCBP2 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
MYD88 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@ngoOncogenicallyActiveMYD882011a], CE[@guoSGK1MutationStatus2022b] Dreval et al [@ngoOncogenicallyActiveMYD882011a; @yanBCRTLRSignaling2012a]
NFKBIA Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al [@thomasMutationalAnalysisIkappaBalpha2004; @wienandGenomicAnalysesFlowsorted2019b]
OR8H2 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
P2RY8 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@muppidiLossSignalingGa132014b] Dreval et al [@lohrDiscoveryPrioritizationSomatic2012a; @muppidiLossSignalingGa132014b]
PDS5B Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al [@morinMutationalStructuralAnalysis2013]
PPP4C Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
PRKDC Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al [@schmitzGeneticsPathogenesisDiffuse2018a]
PTPRD Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023] Dreval et al [@spinaGeneticsNodalMarginal2016b]
PZP Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
RBM6 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
S1PR2 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@floriHematopoieticOncoproteinFOXP12016] Dreval et al [@morinFrequentMutationHistonemodifying2011; @muppidiLossSignalingGa132014b]
SHROOM3 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
SOCS1 Tier 2 GE[@drevalGeneticSubdivisionsFollicular2023], FE[@melznerBiallelicMutationSOCS12005a] Dreval et al [@morinFrequentMutationHistonemodifying2011; @wenigerMutationsTumorSuppressor2006a]
SRRM2 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al [@morinMutationalStructuralAnalysis2013]
STAB2 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
TMEM30A Tier 2 GE[@morinFrequentMutationHistonemodifying2011], FE[@ennishiTMEM30ALossoffunctionMutations2020b], CE[@ennishiTMEM30ALossoffunctionMutations2020b] Morin et al
TPP1 Tier 2 GE[@hubschmannMutationalMechanismsShaping2021b] Hubschmann et al
XIRP2 Tier 2 GE[@russler-germainMutationsAssociatedProgression2023b] Russler et al
ZC3H12A Tier 2 GE [@chapuyMolecularSubtypesDiffuse2018b]
ZNF608 Tier 2 GE[@krysiakRecurrentSomaticMutations2017b] Krysiak et al [@morinMutationalStructuralAnalysis2013]

Tier 3 FL genes

0 total

Gene Summary First FL study Other entities QC result

References

Disclaimer

The content in these pages has been populated, in part, by an automated process. Although we have scrutinized every page to ensure accuracy, errors will inevitably exist. If you find an error please report it as an issue and we will address it.

In particular, let us know if you feel that an important citation is missing or if a paper has been cited incorrectly.

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

Share — copy and redistribute the material in any medium or format for any purpose, even commercially.

Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms.

Clone this wiki locally