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rdmorin edited this page May 28, 2024 · 11 revisions

GRIN2A

History

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timeline
    title Publication timing
      2014-05-08 : Zhang : MCL
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Relevance tier by entity

Entity Tier Description
MCL 2 relevance in MCL not firmly established

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
MCL GAMBL genomes 0.47

Mutation pattern and selective pressure estimates

Entity aSHM Significant selection dN/dS (missense) dN/dS (nonsense)
BL No No 0.437 4.209
DLBCL No No 0.961 0.000
FL No No 0.618 0.000

Note

First described in MCL in 2014 by Zhang J

View coding variants in ProteinPaint hg19 or hg38

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View all variants in GenomePaint hg19 or hg38

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GRIN2A Expression

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References

  1. Zhang J, Jima D, Moffitt AB, Liu Q, Czader M, Hsi ED, Fedoriw Y, Dunphy CH, Richards KL, Gill JI, Sun Z, Love C, Scotland P, Lock E, Levy S, Hsu DS, Dunson D, Dave SS. The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. Blood. 2014 May 8;123(19):2988–2996.

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