---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![DLBCL](images/icons/DLBCL_tier2.png) |2   |relevance in DLBCL not firmly established[@schmitzGeneticsPathogenesisDiffuse2018]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |0.96         |
|DLBCL |Schmitz cohort|4.04         |
|DLBCL |Reddy cohort  |1.50         |
|DLBCL |Chapuy cohort |2.14         |

## Mutation pattern and selective pressure estimates

|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
|:------:|:----:|:---------------------:|:----------------:|:----------------:|
|BL    |No  |No                   |0.723           |0               |
|DLBCL |No  |No                   |3.101           |0               |
|FL    |No  |No                   |0.000           |0               |




[[include:browser_GSG2.md]]

## Expression
![](images/gene_expression/GSG2_by_pathology.svg)
<!-- ORIGIN: schmitzGeneticsPathogenesisDiffuse2018a -->
<!-- DLBCL: schmitzGeneticsPathogenesisDiffuse2018a -->

[[include:mermaid_GSG2.md]]

## References