HIST1H1C
[[TOC]]
This is one of several genes that encode linker histone proteins that are recurrently mutated in DLBCL and FL.[@morinFrequentMutationHistonemodifying2011; @crouchMolecularSubclustersFollicular2022] Mutations are often found in the globular domain of the protein, which is critical for its interaction with DNA and other histone proteins.
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
1 | high-confidence DLBCL gene [@morinFrequentMutationHistonemodifying2011] |
 |
1 | high-confidence FL gene [@morinFrequentMutationHistonemodifying2011] |
 |
3 | Retired, Failed QC[@paneaWholeGenomeLandscape2019]] |
<<Warn("The variants reported in BL in this gene failed QC")>>
See below or the study page for more information
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