---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview

This is one of several genes that encode linker histone proteins that are recurrently mutated in DLBCL and FL.[@morinFrequentMutationHistonemodifying2011; @crouchMolecularSubclustersFollicular2022] Mutations are often found in the globular domain of the protein, which is critical for its interaction with DNA and other histone proteins. 



## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene            [@morinFrequentMutationHistonemodifying2011]|
|![FL](images/icons/FL_tier1.png)    |1   |high-confidence FL gene               [@morinFrequentMutationHistonemodifying2011]|
|![BL](images/icons/BL_tier2.png)    |3   |Retired, Failed QC[@paneaWholeGenomeLandscape2019]]|

## Warnings

<<Warn("The variants reported in BL in this gene failed QC")>>

**[See below ](#representative-mutations) or [the study page ](papers/paneaWholeGenomeLandscape2019.md#tier-2) for more information**

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

### DLBCL
[[include:DLBCL_HIST1H1C.md]]

### BL

[[include:BL_HIST1H1C.md]]

### FL

[[include:FL_HIST1H1C.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_HIST1H1C.md]]


[[include:browser_HIST1H1C.md]]