---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview
This is one of several genes that encode linker histone proteins that are recurrently mutated in DLBCL and FL.[@morinMutationalStructuralAnalysis2013; @krysiakRecurrentSomaticMutations2017]
Mutations are often found in the globular domain of the protein, which is critical for its interaction with DNA and other histone proteins. 


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established[@jalladesExomeSequencingIdentifies2017]|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene            [@morinMutationalStructuralAnalysis2013; @chapuyMolecularSubtypesDiffuse2018]|
|![FL](images/icons/FL_tier1.png)    |1   |high-confidence FL gene               [@krysiakRecurrentSomaticMutations2017]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

### DLBCL
[[include:DLBCL_HIST1H1D.md]]

### BL
[[include:BL_HIST1H1D.md]]

### FL
[[include:FL_HIST1H1D.md]]

## Mutation pattern and selective pressure estimates

[[include:dnds_HIST1H1D.md]]




[[include:browser_HIST1H1D.md]]