---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview

This gene encodes the H2A protein, one of the core proteins comprising nucleosomes. Although relatively common in DLBCL, little is known about the function of these mutations. 




## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established[@rossiCodingGenomeSplenic2012]|
|![BL](images/icons/BL_tier2.png)    |3   |Retired, Failed QC[@paneaWholeGenomeLandscape2019]|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene            [@zhangGeneticHeterogeneityDiffuse2013; @chapuyMolecularSubtypesDiffuse2018]|

## Warnings

<<Warn("The variants reported in this gene in BL failed QC")>>

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

### DLBCL
[[include:DLBCL_HIST1H2BK.md]]

### BL
[[include:BL_HIST1H2BK.md]]

### FL
[[include:FL_HIST1H2BK.md]]

## Mutation pattern and selective pressure estimates
[[include:dnds_HIST1H2BK.md]]




[[include:browser_HIST1H2BK.md]]