---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description               |
|:------:|:----:|--------------------------|
|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established[@reichelFlowSortingExome2015]|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene[@lohrDiscoveryPrioritizationSomatic2012]|
|![FL](images/icons/FL_tier1.png)    |1   |high-confidence FL gene   |

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

### DLBCL
[[include:DLBCL_HIST1H3B.md]]

### BL
[[include:BL_HIST1H3B.md]]

### FL
[[include:FL_HIST1H3B.md]]


## Mutation pattern and selective pressure estimates
[[include:dnds_HIST1H3B.md]]



## HIST1H3B Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
|chr6|26032045|C>T|D82N| 
|chr6|26032029|C>G|S87T| 
|chr6|26032029|C>T|S87N| 
|chr6|26032028|G>C|S87R| 
|chr6|26032021|C>T|V90M| 
|chr6|26032017|A>G|M91T| 


[[include:browser_HIST1H3B.md]]