---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![BL](images/icons/BL_tier2.png)    |2   |relevance in BL not firmly established[@paneaWholeGenomeLandscape2019]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source               |frequency (%)|
|:------:|:---------------------:|:-------------:|
|BL    |GAMBL genomes+capture|2.31         |
|BL    |Thomas cohort        |1.70         |
|BL    |Panea cohort         |3.00         |

## Mutation pattern and selective pressure estimates

|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
|:------:|:----:|:---------------------:|:----------------:|:----------------:|
|BL    |No  |No                   |2.566           |0               |
|DLBCL |No  |No                   |2.153           |0               |
|FL    |No  |No                   |0.000           |0               |




## HIST1H3D Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr6 | 26197218 | G>C | S87R |
| chr6 | 26197219 | C>G | S87T |
| chr6 | 26197219 | C>T | S87N |

[[include:browser_HIST1H3D.md]]