---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![BL](images/icons/BL_tier2.png)    |2   |relevance in BL not firmly established[@paneaWholeGenomeLandscape2019]|
|![FL](images/icons/FL_tier2.png)    |2   |relevance in FL not firmly established[@krysiakRecurrentSomaticMutations2017]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source               |frequency (%)|
|:------:|:---------------------:|:-------------:|
|BL    |GAMBL genomes+capture|0.46         |
|BL    |Thomas cohort        |0.00         |
|BL    |Panea cohort         |2.00         |
|FL    |GAMBL genomes        |1.15         |

## Mutation pattern and selective pressure estimates

|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
|:------:|:----:|:---------------------:|:----------------:|:----------------:|
|BL    |No  |No                   |0.000           |0               |
|DLBCL |No  |No                   |5.397           |0               |
|FL    |No  |No                   |0.838           |0               |




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