---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]





## Relevance tier by entity

|Entity|Tier|Description                           |
|:------:|:----:|--------------------------------------|
|![BL](images/icons/BL_tier2.png)    |3   |Retired, Failed QC[@paneaWholeGenomeLandscape2019]|

## Warnings

<<Warn("The variants reported in this gene failed QC")>>

**[See below ](#representative-mutations) or [the study page ](papers/paneaWholeGenomeLandscape2019.md#tier-2) for more information**

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source               |frequency (%)|
|:------:|:---------------------:|:-------------:|
|BL    |GAMBL genomes+capture|2.31         |
|BL    |Thomas cohort        |1.70         |
|BL    |Panea cohort         |5.00         |

## Mutation pattern and selective pressure estimates

|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
|:------:|:----:|:---------------------:|:----------------:|:----------------:|
|BL    |No  |No                   |6.396           |0               |
|DLBCL |No  |No                   |1.417           |0               |
|FL    |No  |No                   |0.000           |0               |




## HIST1H3J Hotspots

| Chromosome |Coordinate (hg19) | ref>alt | HGVSp | 
 | :---:| :---: | :--: | :---: |
| chr6 | 27858236 | G>C | A112G |
| chr6 | 27858222 | G>A | R117C |
| chr6 | 27858210 | T>G | M121L |

[[include:browser_HIST1H3J.md]]