---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]

## Overview
This gene encodes the H2A protein, one of the core proteins comprising nucleosomes. Although relatively common in DLBCL, little is known about the function of these mutations. 


## Relevance tier by entity

|Entity|Tier|Description               |
|:------:|:----:|--------------------------|
|![DLBCL](images/icons/DLBCL_tier1.png) |1   |high-confidence DLBCL gene[@schmitzGeneticsPathogenesisDiffuse2018]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

### DLBCL
[[include:DLBCL_HIST2H2BE.md]]

### BL
[[include:BL_HIST2H2BE.md]]

## Mutation pattern and selective pressure estimates
[[include:dnds_HIST2H2BE.md]]


[[include:browser_HIST2H2BE.md]]

## Expression
![](images/gene_expression/HIST2H2BE_by_pathology.svg)
<!-- ORIGIN: schmitzGeneticsPathogenesisDiffuse2018a -->
<!-- DLBCL: schmitzGeneticsPathogenesisDiffuse2018a -->

[[include:mermaid_HIST2H2BE.md]]

## References