---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]



## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established[@jalladesExomeSequencingIdentifies2017]|
|![DLBCL](images/icons/DLBCL_tier2.png) |3   |Retired, Failed QC[@reddyGeneticFunctionalDrivers2017]|

## Warnings

<<Warn("The variants reported in this gene in DLBCL failed QC")>>

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |  NA         |
|DLBCL |Schmitz cohort|0.21         |
|DLBCL |Reddy cohort  |0.70         |
|DLBCL |Chapuy cohort |0.43         |

## Mutation pattern and selective pressure estimates

[[include:dnds_HRAS.md]]




[[include:browser_HRAS.md]]

## Expression
![](images/gene_expression/HRAS_by_pathology.svg)
<!-- ORIGIN: reddyGeneticFunctionalDrivers2017 -->
<!-- MZL: jalladesExomeSequencingIdentifies2017 -->
<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->

## All Mutations

[Reddy_2463T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2463T.html)
[Reddy_2565T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2565T.html)
[Reddy_2637T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2637T.html)
[Reddy_2643T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2643T.html)
[Reddy_2659T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2659T.html)
[Reddy_2777T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2777T.html)
[Reddy_2912T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2912T.html)
[Reddy_3385T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3385T.html)
[Reddy_3417T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3417T.html)
[Reddy_3482T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3482T.html)
[Reddy_3496T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3496T.html)
[Reddy_3537T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3537T.html)
[Reddy_3580T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3580T.html)
[Reddy_3631T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3631T.html)
[Reddy_3726T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3726T.html)
[Reddy_3751T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3751T.html)
[Reddy_3811T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3811T.html)
[Reddy_3845T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3845T.html)
[Reddy_3851T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3851T.html)

[[include:mermaid_HRAS.md]]

## References