---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![DLBCL](images/icons/DLBCL_tier2.png) |2   |relevance in DLBCL not firmly established[@morinMutationalStructuralAnalysis2013]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |0.38         |
|DLBCL |Schmitz cohort|1.91         |
|DLBCL |Reddy cohort  |0.60         |
|DLBCL |Chapuy cohort |1.28         |

## Mutation pattern and selective pressure estimates

[[include:dnds_IER2.md]]


## IER2 Expression
![](images/gene_expression/IER2_by_pathology.svg)
<!-- ORIGIN: morinMutationalStructuralAnalysis2013 -->
<!-- DLBCL: morinMutationalStructuralAnalysis2013 -->

## All Mutations

[RG115](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG115.html)
[RG136](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG136.html)

[[include:mermaid_IER2.md]]

## References