IGLL5

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bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

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Relevance tier by entity

Entity	Tier	Description
	2	relevance in PMBL/cHL/GZL not firmly established[@deschGenotypingCirculatingTumor2020]
	2	aSHM target; Although recurrent, the relevance of mutations in BL is tenuous [@paneaWholeGenomeLandscape2019]
	2	aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous
	2	aSHM target; Although recurrent, the relevance of mutations in FL is tenuous [@russler-germainMutationsAssociatedProgression2023]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
BL	GAMBL genomes+capture	26.33
BL	Thomas cohort	25.00
BL	Panea cohort	23.80
DLBCL	GAMBL genomes	41.49
DLBCL	Schmitz cohort	35.96
DLBCL	Reddy cohort	16.12
DLBCL	Chapuy cohort	8.97
FL	GAMBL genomes	35.33

Mutation pattern and selective pressure estimates

include:dnds_IGLL5.md

aSHM regions

chr_name	hg19_start	hg19_end	region	regulatory_comment
chr22	23229554	23232042	TSS	NA

include:browser_IGLL5.md

Expression

include:mermaid_IGLL5.md

References