---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
---
[[_TOC_]]


## Relevance tier by entity

|Entity|Tier|Description                              |
|:------:|:----:|-----------------------------------------|
|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established[@wienandGenomicAnalysesFlowsorted2019]|
|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established[@rossiAlterationBIRC3Multiple2011]|
|![DLBCL](images/icons/DLBCL_tier2.png) |2   |relevance in DLBCL not firmly established[@reddyGeneticFunctionalDrivers2017]|

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |0.57         |
|DLBCL |Schmitz cohort|2.98         |
|DLBCL |Reddy cohort  |1.10         |
|DLBCL |Chapuy cohort |3.42         |

## Mutation pattern and selective pressure estimates

[[include:dnds_IKBKB.md]]




[[include:browser_IKBKB.md]]

## Expression
![](images/gene_expression/IKBKB_by_pathology.svg)
<!-- ORIGIN: rossiAlterationBIRC3Multiple2011a -->
<!-- MZL: rossiAlterationBIRC3Multiple2011a -->
<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->
<!-- PMBL: wienandGenomicAnalysesFlowsorted2019b -->

[[include:mermaid_IKBKB.md]]

## References